BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Thielavin P | Thielavin P is a glucose-6-phosphatase (G6Pase) inhibitor produced by Chaetomium carinthiacum. Molecular formula: C30H32O10. Mole weight: 552.57. |  |
| Thienamycin | Thienamycin is a β-lactam antibiotic produced by Str. cattleya NRRL8057. Broad-spectrum antibacterial activity. Synonyms: (5R,6S)-3-[(2-Aminoethyl)thio]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; [5R-[5α,6α(R*)]]-3-[(2-Aminoethyl)thio]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (+)-Thienamycin. Grades: > 95%. CAS No. 59995-64-1. Molecular formula: C11H16N2O4S. Mole weight: 272.32. | |
| Thioactin | Thioactin is produced by the strain of Str. sp. DP94. The minimum inducing concentration of X to the promoter TIP-1 was 40 ng/mL. Molecular formula: C43H40N14O11S4. Mole weight: 1057.12. | |
| Thiocillin I | It is the simplest of the macrocyclic thiazole peptide antibiotic first isolated from bacillus badius and bacillus cereus. It has anti-gram-positive bacteria activity. Synonyms: 44-O-Demethylthiocillin II; G-15-II; 2'-[(11S, 14Z, 21S, 28S)-14-ethylidene-9, 10, 11, 12, 13, 14, 20, 21, 27, 28-decahydro-11, 28-bis[(1R)-1-hydroxyethyl]-21-(1-hydroxy-1-methylethyl)-9, 12, 19, 26-tetraoxo-19H, 26H-8, 5:18, 15:25, 22:32, 29-tetranitrilo-5H, 15H-pyrido[3, 2-m][1, 11, 17, 24, 4, 7, 20, 27]tetrathiatetraazacyclotriacontin-2-yl]-N-[(1Z)-1-[[[(2R)-2-hydroxypropyl]amino]carbonyl]-1-propen-1-yl]-[2, 4'-bithiazole]-4-carboxamide. Grades: >95% by HPLC. CAS No. 59979-01-0. Molecular formula: C48H49N13O10S6. Mole weight: 1160.37. | |
| Thiocoraline | Thiocoraline is a peptide antibiotic produced by Micromonospora sp. L-13-ACM2-092. It has strong anti-Gram-positive bacteria and weak anti-Gram-negative bacteria activity. The effect of inhibiting RNA synthesis is stronger than that of inhibiting DNA synthesis. Cytotoxic activity. Synonyms: Thicoraline; Thi Coraline. Grades: >98%. CAS No. 173046-02-1. Molecular formula: C48H56N10O12S6. Mole weight: 1157.41. | |
| Thiolutin | Thiolutin is a sulfur-containing antibiotic from Streptomyces albus and Streptomyces pimprina that inhibits RNA synthesis directed by all three yeast RNA polymerase. Uses: Inhibitor of dna-primed rna polimerase and dna polimerase. apoptosis inducer. antineoplastic drug. Synonyms: Acetopyrrothin; Acetopyrrothine. Grades: >98%. CAS No. 87-11-6. Molecular formula: C8H8N2O2S2. Mole weight: 228.29. | |
| Thiomarinol A | Thiomarinol A is produced by a marine bacterium Alteromonas rava SANK T3390. It is resistant to Gram-positive and Gram-negative bacteria and also has an effect on MRSA. Synonyms: (5S)-1,5-anhydro-2-deoxy-2-[(2E,4R,5S)-5-hydroxy-4-methylhex-2-en-1-yl]-5-[(1R,2E)-1-hydroxy-2-methyl-4-oxo-4-({8-oxo-8-[(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)amino]octyl}oxy)but-2-en-1-yl]-L-arabinitol. Grades: 96%. CAS No. 146697-04-3. Molecular formula: C30H44N2O9S2. Mole weight: 640.81. | |
| Thiomarinol B | Thiomarinol B is produced by a marine bacterium Alteromonas rava SANK T3390. It is resistant to Gram-positive and Gram-negative bacteria and also has an effect on MRSA. Synonyms: (5S)-1,5-anhydro-2-deoxy-5-[(1R,2E)-4-({8-[(2,2-dioxido-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)amino]-8-oxooctyl}oxy)-1-hydroxy-2-methyl-4-oxobut-2-en-1-yl]-2-[(2E,4R,5S)-5-hydroxy-4-methylhex-2-en-1-yl]-L-arabinitol. Molecular formula: C30H44N2O11S2. Mole weight: 672.81. | |
| Thiomarinol D | Thiomarinol D is produced by a marine bacterium Alteromonas rava SANK T3390. It is resistant to Gram-positive and Gram-negative bacteria and also has an effect on MRSA. Synonyms: (5S)-1,5-anhydro-2-deoxy-2-[(2E,4R,5S)-5-hydroxy-4-methylhept-2-en-1-yl]-5-[(1R,2E)-1-hydroxy-2-methyl-4-oxo-4-({8-oxo-8-[(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)amino]octyl}oxy)but-2-en-1-yl]-L-arabinitol. Molecular formula: C31H46N2O9S2. Mole weight: 654.83. | |
| Thiomarinol E | Thiomarinol E is produced by a marine bacterium Alteromonas rava SANK T3390. It is resistant to Gram-positive and Gram-negative bacteria and also has an effect on MRSA. Synonyms: (5S)-1,5-anhydro-2-deoxy-2-[(2E,4R,5S)-5-hydroxy-4-methylhex-2-en-1-yl]-5-[(1R,2E)-1-hydroxy-2-methyl-4-oxo-4-({10-oxo-10-[(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)amino]decyl}oxy)but-2-en-1-yl]-L-arabinitol. Molecular formula: C32H48N2O9S2. Mole weight: 668.86. | |
| Thiotetromycin | It is originally isolated from Str. sp. OM-674. Thiotetromycin has the effect of resisting anaerobe fragile bacteroidetes, and also resisting other bacteria, but the activity is weak. Synonyms: Antibiotic OM 674; (R-(E))-3,5-Diethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone; (2R)-2,4-diethyl-5-hydroxy-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one. CAS No. 85263-97-4. Molecular formula: C13H18O2S. Mole weight: 238.35. | |
| Thioxamycin | Thioxamycin is produced by the strain of Str. sp. DP94. The minimum inducing concentration of X to the promoter TIP-1 was 80 ng/mL. Synonyms: Sulfomycin I, 58-(1-carboxyethenyl)-28-deethylidene-14-de(2-hydroxypropylidene)-21-demethoxy-17,31-didemethyl-28-methyl-14-((methylthio)methyl)-30-thia-. Grades: ≥98%. CAS No. 124883-37-0. Molecular formula: C52H48N16O15S4. Mole weight: 1265.29. | |
| Thr-Ala-OH | Synonyms: L-Threonyl-L-alanine; Thr Ala OH. Grades: ≥ 99% (TLC). CAS No. 56217-50-6. Molecular formula: C7H14N2O4. Mole weight: 190.2. | |
| Thrazarine | Thrazarine is produced by the strain of Str. coerulescens MH802 fF5. It inhibits DNA synthesis and the growth of tumor cells. Synonyms: O-((3R)-2-Diazo-3-hydroxybutyryl)-L-serine; (Z,3R)-1-[(2S)-2-amino-2-carboxyethoxy]-2-diazonio-3-hydroxybut-1-en-1-olate. Grades: ≥98%. CAS No. 120128-14-5. Molecular formula: C7H11N3O5. Mole weight: 217.18. | |
| Thr-Thr-Thr-OH | Synonyms: L-threonyl-L-threonyl-L-threonine; Thr Thr Thr OH. CAS No. 56395-09-6. Molecular formula: C12H23N3O7. Mole weight: 321.33. | |
| Thuringione | Thuringione can inhibit the growth of mouse SV40-transformed ileocecal blastoma cells in vitro. Synonyms: Xanthen-9-one, 2,4,5-trichloro-1,6-dihydroxy-3-methoxy-8-methyl- (8CI). CAS No. 22105-34-6. Molecular formula: C15H9Cl3O5. Mole weight: 375.59. | |
| Thymopentin | Thymopentin is a polypeptide and an effective immunomodulatory agent. Synonyms: Thymopoietin (32-36); TP-5; Thymopoietin Pentapeptide; Timunox; Thymopentin Acetate. Grades: ≥97% by HPLC. CAS No. 69558-55-0. Molecular formula: C30H49N9O9. Mole weight: 679.8. | |
| Thymopentin Acetate | Thymopentin Acetate is a polypeptide and an effective immunomodulatory agent. Synonyms: Thymopentin monoacetate. CAS No. 177966-81-3. Molecular formula: C32H53N9O11. Mole weight: 739.81. | |
| Thymopoietin II (32-34) | Synonyms: ARG-LYS-ASP; H-ARG-LYS-ASP-OH; THYMOPOIETIN II (32-34); TP II (32-34); TP-3; n-(n(sup2)-l-arginyl-l-lysyl)-l-asparticaci; n-(n(sup2)-l-arginyl-l-lysyl)-l-asparticacid; rgh0205. Grades: 95%. CAS No. 85465-82-3. Molecular formula: C16H31N7O6. Mole weight: 417.46. | |
| Thymopoietin II (32-35) | Synonyms: n-(n-(n(sup2)-l-arginyl-l-lysyl)-l-alpha-aspartyl)-l-valin; n-(n-(n(sup2)-l-arginyl-l-lysyl)-l-alpha-aspartyl)-l-valine; rgh0206; H-ARG-LYS-ASP-VAL-OH; ARG-LYS-ASP-VAL; TP-4; TP II (32-35); THYMOPOIETIN II (32-35). Grades: 95%. CAS No. 85466-18-8. Molecular formula: C21H40N8O7. Mole weight: 516.59. | |
| Thyroid-stimulating hormone-releasing hormone | Thyroid-stimulating hormone-releasing hormone is a constitution-stimulating hormone produced by hypothalamic neurons. It can stimulate the anterior pituitary to release thyroid-stimulating hormone and prolactin. Uses: Hormones. Synonyms: Protirelin; TSH-RF; pGlu-His-Pro-NH2; {pGLU}HP-NH2; Thyroliberin; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-; 5-Oxo-L-prolyl-L-histidyl-L-prolinamide; Thyrotropin-releasing factor; (Pyro)-L-glutamic acid-L-histidine-L-proline-NH2; L-Pyroglutamyl-L-histidyl-L-prolinamide; Abbott 38579; Antepan; FDA 1725; Lopremone; Prem; Relefact TRH; Rifathyroin; Rifotironin; Ro 8-6270/9; Stimu TSH; Synthetic thyrotropin-releasing factor; Synthetic thyrotropin-releasing hormone; Synthetic TRF; Synthetic TRH; Thypinone; Thyrefact; Thyroid releasing hormone; Thyroid-stimulating hormone-releasing factor; TRF; TRH; TSH-releasing factor; TSH-releasing hormone. Grades: 95%. CAS No. 24305-27-9. Molecular formula: C16H22N6O4. Mole weight: 362.38. | |
| Thyroliberin acetate salt | Thyroliberin acetate salt is a highly conserved neuropeptide that stimulates the release of thyrotropin and prolactin and plays a hormonal role in controlling thyroid-stimulating hormone (TSH) levels and neuromodulatory functions. Synonyms: Lopremone Acetate; TRH Acetate; Thyroliberin Acetate; TRF Acetate; pGlu-His-Pro-NH2 Acetate; Synthetic thyrotropin-releasing hormone Acetate; Protirelin acetate; Protirelin monoacetate; H-Pyr-His-Pro-NH2.CH3CO2H; Pyr-HP-NH2.CH3CO2H; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, acetate (1:1); L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-, monoacetate; Thyrotropin-releasing factor (pig), monoacetate; Pyroglutamylhistidylprolinamide acetate; Thyrotropin-releasing hormone acetate; L-pyroglutamyl-L-histidyl-L-prolinamide acetic acid. Grades: ≥95%. CAS No. 25575-91-1. Molecular formula: C18H26N6O6. Mole weight: 422.44. | |
| Thyrotropin | Thyroid-stimulating hormone is a pituitary hormone that stimulates the thyroid gland to produce thyroxine. Synonyms: TSH. Grades: 95%. CAS No. 9002-71-5. | |
| Thyrotropin-Releasing Hormone (TRH), Free Acid | Synonyms: TRH; Thyroliberin; Thyrotropin-releasing hormone; Prothyroliberin. Grades: >95%. CAS No. 24769-58-2. Molecular formula: C16H21N5O5. Mole weight: 363.37. | |
| Tiacumicin A | It is originally isolated from Dactylosporangium aurantiacum sub sp. hamdenensis subsp. nov. AB718C-41. Tiacumicin A has the effect of resisting gram-positive bacteria. CAS No. 109713-94-2. Molecular formula: C34H52O9. Mole weight: 604.77. | |
| Tiacumicin C | It is originally isolated from Dactylosporangium aurantiacum sub sp. hamdenensis subsp. nov. AB718C-41. Tiacumicin C has the effect of resisting gram-positive bacteria. Synonyms: Clostomicin B2; Lipiarmycin B3; Benzoic acid, 3,5-dichloro-4,6-dihydroxy-2-ethyl-, 4'(3)-ester with 3-(((6-deoxy-2-O-methyl-beta-L-mannopyranosyl)oxy)methyl)-12-((6-deoxy-5-C-methyl-2-O-(2-methyl-1-oxopropyl)-beta-D-lyxo-hexopyranosyl)oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one. CAS No. 106008-70-2. Molecular formula: C52H74Cl2O18. Mole weight: 1058.04. | |
| Tiacumicin F | It is originally isolated from Dactylosporangium aurantiacum sub sp. hamdenensis sub sp. nov. AB718C-41. Tiacumicin C has the effect of resisting gram-positive bacteria. It also has the activity of inhibiting pathogenic Staphylococcus aureus and multi-dose drug-resistant bacteria. Synonyms: Clostomycin A; Benzoic acid, 3,5-dichloro-4,6-dihydroxy-2-ethyl-, 4'(3)-ester with 3-(((6-deoxy-2-O-methyl-beta-L-mannopyranosyl)oxy)methyl)-12-((6-deoxy-5-C-methyl-3-O-(2-methyl-1-oxopropyl)-beta-D-lyxo-hexopyranosyl)oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one; Fidaxomicin Impurity 4. CAS No. 106008-69-9. Molecular formula: C52H74Cl2O18. Mole weight: 1058.04. | |
| Tiamulin | Tiamulin is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry. Tiamulin is active against gram-positive bacteria, mycoplasmas, and anaerobes, including Brachyspira hyodysenteriae. Uses: Anti-bacterial agents. Synonyms: Acetic acid, 2-[[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester; Acetic acid, [[2-(diethylamino)ethyl]thio]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα, 4β, 5α, 6α, 8β, 9α, 9aβ, 10S*)]-; Denagard; Thiamutilin; Tiavet P; (3aS,4R,5S,6S,8R,9S,9aR,10R)-2-[[2-(Diethylamino)ethyl]thio]acetic Acid 6-Ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester. Grades: >98% by HPLC. CAS No. 55297-95-5. Molecular formula: C28H47NO4S. Mole weight: 493.74. | |
| Tiamulin fumarate | Tiamulin Fumarate is a derivative of Pleuromutilin, which acts as an antibacterial. It is an antibiotic with activity against a variety of mycoplasma and gram-positive bacteria. Synonyms: (3aS,4R,5S,6S,8R,9S,9aR,10R)-2-[[2-(Diethylamino)ethyl]thio]acetic Acid 6-Ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester (2E)-2-Butenedioate; SQ-22947; Denagard; Dynamutilin; Tiamutin; Tiavet; Acetic acid, 2-[[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, (2E)-2-butenedioate (1:1); Acetic acid, [[2-(diethylamino)ethyl]thio]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα, 4β, 5α, 6α, 8β, 9α, 9aβ, 10S*)]-, (E)-2-butenedioate (1:1) (salt); 14-Deoxy-14-[(2-diethylaminoethyl)-mercaptoacetoxy]mutilin hydrogen fumarate; 81723hfu; Sandoz 81723hfu; Thiamutilin fumarate; Tiamulin hydrogen fumarate; Tiamupharm; Vievitin. Grades: ≥95%. CAS No. 55297-96-6. Molecular formula: C32H51NO8S. Mole weight: 609.81. | |
| Ticarcillin disodium Clavulanate potassium (15:1) (Timentin) | A broad-spectrum beta-lactam antibiotic in the carboxypenicillin family. Synonyms: Ticarcillin disodium with Clavulanate potassium (15:1) (Timentin). Grades: ≥99.0%. CAS No. 116876-37-0. Molecular formula: 15(C15H14Na2N2O6S2).C8H8KNO5. | |
| Tilarginine | Synonyms: N-Monomethyl-L-arginine; L-Monomethylarginine. Grades: > 98.0% (TLC). CAS No. 17035-90-4. Molecular formula: C7H16N4O2. Mole weight: 188.23. | |
| Tilmicosin Phosphate | Tilmicosin phosphate, an antibiotic, has been commonly used as a veterinary drug against ovine respiratory disease for bovine and ovine. Synonyms: Tilmicosin (phosphate); UNII-SMH7U1S683; SMH7U1S683; Tilmicosin phosphate (USAN). Grades: 98%. CAS No. 137330-13-3. Molecular formula: C46H83N2O17P. Mole weight: 967.13. | |
| TL-119 | TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9. | |
| TMC-135A | TMC-135A is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60 with IC50 values of 0.07, 0.88, 0.11, 0.20, 0.15 and 0.05 μmol/L, respectively. Synonyms: TMC-135 A. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-135B | TMC-135B is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60. Synonyms: TMC-135 B. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-154 | TMC-154 is an antibiotic produced by Gliocladium sp. TC 1282. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC 154. Molecular formula: C41H72O14. Mole weight: 789. | |
| TMC-169 | TMC-169 is an antibiotic of the aspochalasin group produced by Aspergillus flavipes TC 1446. It has cytotoxicity. Synonyms: TMC 169. Molecular formula: C24H35NO3. Mole weight: 385.5. | |
| TMC-171A | TMC-171A is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 A. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171B | TMC-171B is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 B. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171C | TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 C. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-1A | TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1B | TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1C | TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6. | |
| TMC-1D | TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6. | |
| TMC-256A1 | TMC-256A1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 25 μmol/L. Synonyms: TMC-256 A1. CAS No. 3773-18-0. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-256C1 | TMC-256C1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 1.7 μmol/L. Synonyms: TMC-256 C1. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-260 | TMC-260 is an inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703. It inhibited the IL-4 driven luciferase activity with IC50 values of 9 μmol/L. Synonyms: TMC 260. Molecular formula: C17H27NO5. Mole weight: 325.4. | |
| TMC-264 | TMC-264 is a STAT6 activation inhibitor produced by Phoma sp. TC 1674. It suppressed expression of IL-4 driven luciferase and germline Cepsilon mRNA with IC50 values of 0.3 and 0.4 μmol/L, respectively, and inhibited tyrosine phosphorylation of STAT6 with an IC50 value of 1.6 μmol/L. Synonyms: TMC 264. Molecular formula: C16H13ClO7. Mole weight: 352.72. | |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-34 | TMC-34 is an macrolide antifungal antibiotic produced by Streptomyces sp. A-3030. Synonyms: TMC 34. Molecular formula: C54H93N3O17. Mole weight: 1056.3. | |
| TMC-49A | TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Synonyms: TMC-49 A; 2-phenylethyl n-butyl carbamate. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-66 | TMC-66 is a selective endothelin conversion enzyme (ECE) inhibitor isolated from the culture broth of Streptomyces sp. A5008. Synonyms: TMC 66. Molecular formula: C29H21NO9. Mole weight: 527.5. | |
| TMC-69 | TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity. Synonyms: TMC 69. Molecular formula: C26H31NO4. Mole weight: 421.5. | |
| TMC-86A | TMC-86A is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 5.1 and 3.7 μmol/L, respectively. Synonyms: TMC-86 A. Molecular formula: C16H26N2O6. Mole weight: 342.39. | |
| TMC-86B | TMC-86B is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 1.1 and 31 μmol/L, respectively. Synonyms: TMC-86 B. Molecular formula: C20H34N2O7. Mole weight: 414.5. | |
| TMC-89A | TMC-89A is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.39 and 7.2 μmol/L, respectively. Synonyms: TMC-89 A; N-[(2R)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-89B | TMC-89B is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.51 and 7.1 μmol/L, respectively. Synonyms: TMC-89 B; N-[(2S)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-95A | TMC-95A is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 values of 5.4nM, 200nM, and 60nM, respectively. Synonyms: TMC-95 A. CAS No. 220666-21-7. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95B | TMC-95B is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome to the same extent as TMC-95A. Synonyms: TMC-95 B. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95C | TMC-95C is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 C. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95D | TMC-95D is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 D. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-96 | TMC-96 is a proteasome inhibitor produced by Saccharothrix sp. TC 1094. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 2.9 and 3.5 μmol/L, respectively. Synonyms: TMC 96. Molecular formula: C18H32N2O6. Mole weight: 372.5. | |
| Tolypomycin R | Tolypomycin R is produced by the strain of Str. tolypophorus B2847. It has a broad-spectrum antimicrobial effect, which protects mice infected with gram-positive bacteria, and also has an inhibitory effect on vaccine virus. Synonyms: B-2847-R; L-erythro-Hexopyranose, 2, 3, 4, 6-tetradeoxy-4-((5, 6, 11, 12, 13, 14, 15, 16, 16a, 17, 17a, 18, 21, 22-tetradecahydro-2, 12, 14, 16, 26-pentahydroxy-10-methoxy-3, 6, 11, 13, 15, 20-hexamethyl-5, 18, 21-trioxo-10H-4, 6-epoxy-1, 23-methenobenzo(d)cycloprop(n)(1, 9)oxaazacyclotetracosin-25-yl)amino)-, 12-acetate. Grades: >98%. CAS No. 33889-22-4. Molecular formula: C43H56N2O14. Mole weight: 824.91. | |
| Tolypomycin Y | Tolypomycin Y is produced by the strain of Str. tolypophorus B2847. It has a broad-spectrum antimicrobial effect, which protects mice infected with gram-positive bacteria, and also has an inhibitory effect on vaccine virus. Synonyms: NSC-177383; Tolypromycin Y. Grades: 96%. CAS No. 23412-26-2. Molecular formula: C43H54N2O14. Mole weight: 822.89. | |
| Topopyrone A | It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 1.22 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H9ClO7. Mole weight: 372.71. | |
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