BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GroPI | GroPI is the building block for phosphoinositide polyphosphates and is a substrate for PI-PLC. Phosphatidylinositol is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. Alternative Names: Glycerophosphoinositol. Grades: >95%. CAS No. 129830-95-1. Molecular formula: C9H18NaO11P. Mole weight: 356.20. |  |
| GroPI(4,5)P2 | GroPI(4,5)P2 is a synthetic and purified PI(4,5)P2 without acyl chains at the 1- and 2-positions of the glycerol. PI(4,5)P2 has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. Alternative Names: Glycerophosphoinositol 4,5-diphosphate. Grades: >95%. CAS No. 111188-72-8. Molecular formula: C9H16Na5O17P3. Mole weight: 604.10. | |
| Grundmann's ketone | Grundmann's Ketone is an intermediate in synthesizing (7Z)-Calcipotriene, which is an isomeric impurity of Calcipotriene, a vitamin D3 analogue with low calcemic activity. Alternative Names: 1-((1R)-1,5-Dimethylhexyl)octahydro-7a-methyl-4H-inden-4-one, (1R,3aR,7aR)-. CAS No. 66251-18-1. Molecular formula: C18H32O. Mole weight: 264.45. | |
| GS-441524 | GS-441524 is an analog nucleotide inhibitor against feline infectious peritonitis virus (FIPV). EC50 is 0.78?uM. GS-441524 is also a metabolite and intermediate of Remdesivir. Alternative Names: 2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivir metabolite GS-441524; GS 441524; GS441524; (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. Grades: 97%. CAS No. 1191237-69-0. Molecular formula: C12H13N5O4. Mole weight: 291.26. | |
| GS-443902 | GS-443902 is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. Uses: Antiviral agents. Alternative Names: GS-441524 triphosphate; Remdesivir metabolite; RDV-TP. Grades: 99.87%. CAS No. 1355149-45-9. Molecular formula: C12H16N5O13P3. Mole weight: 531.20. | |
| GS967 | GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Alternative Names: GS967; GS-967; GS 967; GS458967; GS 458967; GS-458967. Grades: 95%. CAS No. 1262618-39-2. Molecular formula: C14H7F6N3O. Mole weight: 347.22. | |
| GSK126 | GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK126 effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Together, these data demonstrate that pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma. Alternative Names: GSK2816126; GSK-2816126; GSK 2816126; GSK-126; GSK 126; (S)-1-(sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide. Grades: 98%. CAS No. 1346574-57-9. Molecular formula: C31H38N6O2. Mole weight: 526.69. | |
| GSK1521498 | GSK-1521498 is a novel μ-Opioid receptor antagonist. It shows to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating in animals and humans. It is mainly used for the treatment of obesity and alcohol dependence. It was developed by GlaxoSmithKline and in clinic phase 2. Uses: Gsk-1521498 is mainly used for the treatment of obesity and alcohol dependence. Alternative Names: GSK-1521498; GSK1521498; GSK 1521498; GSK-1521498B;N-[[2,6-difluoro-4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1H-inden-2-amine;N-((3,5-difluoro-3'-(1H-1,2,4-triazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-inden-2-amine. Grades: >98 %. CAS No. 1007573-18-3. Molecular formula: C24H20F2N4. Mole weight: 402.44. | |
| GSK2256294A | GSK2256294A, an effective inhibitor of human soluble epoxide hydrolase(sEH), was developed by GSK and still under Phase I trial in Chronic obstructive pulmonary disease. IC50: 27pM. Uses: Gsk2256294a is an effective inhibitor of human soluble epoxide hydrolase(seh). Alternative Names: GSK2256294; GSK-2256294; GSK 2256294; GSK-2256294A; GSK 2256294A. Grades: 98%. CAS No. 1142090-23-0. Molecular formula: C21H24F3N7O. Mole weight: 447.46. | |
| GSK2334470 | GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations. GSK2334470 also inhibited T-loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes. Alternative Names: GSK2334470; GSK2334470; GSK2334470. Grades: 0.98. CAS No. 1227911-45-6. Molecular formula: C25H34N8O. Mole weight: 462.602. | |
| GSK256073 | GSK256073 is a potent, selective and orally active G-protein coupled receptor 109A (GPR109A) agonist and a long-lasting and non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) full agonist with a pEC50 of 7.5 for human HCA2. It acutely improves glucose homeostasis by inhibiting lipid breakdown and has the potential to study type 2 diabetes mellitus (T2DM) and dyslipidemia. Alternative Names: 8-Chloro-3-pentyl-1H-purine-2,6(3H,7H)-dione; 1H-Purine-2,6-dione, 8-chloro-3,9-dihydro-3-pentyl-; 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione; 8-Chloro-6-hydroxy-3-pentyl-3,9-dihydro-2H-purin-2-one. Grades: ≥95%. CAS No. 862892-90-8. Molecular formula: C10H13ClN4O2. Mole weight: 256.69. | |
| GSK2636771 | GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt / mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt / mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. Uses: Antineoplastic agents. Alternative Names: GSK2636771; GSK-2636771; GSK 2636771. CAS No. 1372540-25-4. Molecular formula: C22H22F3N3O3. Mole weight: 433.431. | |
| GSK-2881078 | GSK-2881078, an indole derivative, has been found to be an androgen receptor modulator that could probably be effective against Cachexia. It is still under Phase I trail. Uses: Anabolic agents. Alternative Names: GSK 2881078; GSK2881078; CS-5736; (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile. Grades: 98%. CAS No. 1539314-06-1. Molecular formula: C14H13F3N2O2S. Mole weight: 330.33. | |
| GSK467 | GSK467 is a cell penetrant and selective inhibitor of KDM5B (JARID1B/PLU1) with Ki of 10 nM. Alternative Names: GSK-467; GSK 467. CAS No. 1628332-52-4. Molecular formula: C17H13N5O2. Mole weight: 319.32. | |
| GSK 4716 | GSK 4716 is a selective agonist of estrogen-related receptors ERRβ and ERRγ displaying selectivity over ERRα and the classical estrogen receptors. Activation of GSK 4716 regulates mitochondrial activity in skeletal muscle during exercise. Alternative Names: GSK4716; GSK 4716; GSK-4716; 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide. Grades: ≥99% by HPLC. CAS No. 101574-65-6. Molecular formula: C17H18N2O2. Mole weight: 282.34. | |
| GSK J1 | GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases. Alternative Names: GSKJ1; GSKJ 1; GSKJ-1. Grades: 98%. CAS No. 1373422-53-7. Molecular formula: C22H23N5O2. Mole weight: 389.45. | |
| GTP, 100mM Sodium Solution | Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. Alternative Names: D-Guanosine 5'-triphosphate; Guanosine triphosphate; Guanosine 5'-triphosphoric acid; pppG; guanosine 5'-O-(triphosphate); [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Molecular formula: C10H16N5O14P3 (free acid). Mole weight: 523.18 (free acid). | |
| GTP-GAMMA-S SODIUM SALT | GTP-GAMMA-S SODIUM SALT. Alternative Names: guanosine5'-o-(3-thiotriphosphate; guanosine-5'-o-(3-thiotriphosphate),(gtp-g-s),sodiumsalt; GTP-GAMMA-S; GTP-GAMMA-S, NA; GTP-GAMMA-S SODIUM SALT; GUANOSINE-5'-(GAMMA-THIO)-TRIPHOSPHATE, SODIUM SALT; GUANOSINE-5'-[GAMMA-THIO]TRIPHOSPHATE TETRASODIUM SALT; GUAN. CAS No. 37589-80-3. Molecular formula: C10H12N5Na4O13P3S. Mole weight: 627.17. | |
| G-TPP | G-TPP is a mitochondria-targeted Hsp90 inhibitor that increases cell death in HeLa and MCF7 cells, consistently inhibits cell death induced by oxidative stress and mitochondrial dysfunction induced by PINK1 mutation in mouse embryonic fibroblast cells and DA cell models such as SH-SY5Y and SN4741 cells. Additionally, G-TPP also suppresses the defective locomotive activity and DA neuron loss in Drosophila PINK1 null mutants. Alternative Names: G-TPP; G TPP. Grades: >98%. CAS No. 1131626-46-4. Molecular formula: C52H65N3O8P. Mole weight: 890.85. | |
| GUAI-1(5)-EN-11-OL:ACETATE | GUAI-1(5)-EN-11-OL:ACETATE. Alternative Names: [3s-(3alpha,5alpha,8alpha)]-etat; 1-(3,8-Dimethyl-1,2,3,4,5,6,7,8-octahydro-5-azulenyl)-1-methylethyl acetate; 1,2,3,4,5,6,7,8-octahydro-.alpha.. alpha.-3,8-tetramethyl-,acetate,[3S-(3.alpha.,5.alpha.,8.alpha5-Azulenemethanol; 1,2,3,4,5,6,7,8-octahydro-alph. CAS No. 134-28-1. Molecular formula: C17H28O2. Mole weight: 264.4. | |
| guaiacol sulfonic acid potassium | Sulfogaiacol is an antitussive agent, used for acute respiratory tract infections and cough. Alternative Names: sulfogaiacol; potassium 4-hydroxy-3-methoxybenzenesulphonate; Potassium guaiacol sulphonate; Benzenesulfonic acid, hydroxymethoxy-, monopotassium salt. CAS No. 1321-14-8. Molecular formula: C7H7KO5S. Mole weight: 242.29. | |
| Guaiacylglycerol-β-guaiacyl Ether | Guaiacylglycerol-β-guaiacyl Ether. Alternative Names: GUAIACYLGLYCEROL-BETA-GUAIACYL ETHER; 1-(4-HYDROXY-3-METHOXYPHENYL)-2-(2-METHOXYPHENOXY)-1,3-PROPANEDIOL; -guaiacyl ether; Guaiacylglycerol-§ GUAIACYLGLYCEROL-BETA-GUAIACYL ETHER 99+%; Guaiacylglycerol-β-guaiacylether; GUAIACYLGLYCEROL-SS-GUAIACYL ETHER; 1. Grades: 95%. CAS No. 7382-59-4. Molecular formula: C17H20O6. Mole weight: 320.33. | |
| Guaiazulene | Guaiazulene is a lipophilic azulene that is commonly used as a skin conditioning agent in cosmetic, beauty and body care products. It is photomutagenic in Salmonella and also causes DNA damage in human cells. Guaiazulene has the effects of antibacterial, antiviral, anti-inflammatory, anti-allergic, anti-oxidation, protecting against radiation damage and enhancing the protective barrier of the skin. Guaiazulene effectively relieves painful and cracked nipples in women who are nursing. Guaiazulene is used for mouthwash, toothpaste, and mucosal repair products to treat periodontitis, mouth ulcers, plaque, bad breath, and mucosal damage. Alternative Names: 1,4-Dimethyl-7-(1-methylethyl)azulene; Azulene, 7-isopropyl-1,4-dimethyl-; 1,4-Dimethyl-7-(propan-2-yl)azulene; 1,4-Dimethyl-7-isopropylazulene; 3,8-Dimethyl-5-(2-propyl)azulene; 7-Isopropyl-1,4-dimethylazulene; AZ 8; AZ 8 Beris; Azulen-Beris; Azulon; Azunol; Cuteazul; Eucazulen; Guaiazulene; Guaiazulene blue; Kessazulen; NSC 4714; Purazulen; S-Guaiazulene; Silazulon; Uroazulen; Vaumigan; Vetivazulen. Grades: >95%. CAS No. 489-84-9. Molecular formula: C15H18. Mole weight: 198.30. | |
| GUAIENE | GUAIENE. Alternative Names: 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-,(1S-cis)-Azulene; 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-azulen(1s-ci; 1,2,3,4,5,6,7,8-Octahydro-1,4-dimethyl-7-(1-methylethylidene)-azulene; 1,2,3,4,5,6,7,8-octahydro-1,4. Grades: technical. CAS No. 88-84-6. Molecular formula: C15H24. Mole weight: 204.35. | |
| Guaifenesin | Guaifenesin is an expectorant used to treat coughing and chest congestion. Alternative Names: Guaiacol glyceryl ether; Glycerol guaiacolate. Grades: > 98 %. CAS No. 93-14-1. Molecular formula: C10H14O4. Mole weight: 198.22. | |
| Guanabenz Acetate | Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. It is used as an antihypertensive drug. Alternative Names: WY-8678 Acetate; Wytensin, WY-8678, WY 8678, WY8678, EIPA. Grades: >98%. CAS No. 23256-50-0. Molecular formula: C8H8Cl2N4.C2H4O2. Mole weight: 291.13. | |
| Guanidine carbonate salt | Guanidine carbonate salt is used in the cytidine triphosphate injection stabilization. It also acts as a powerful and versatile protein denaturant. Uses: Guanidine carbonate is used for cosmetic formulations, as a hair relaxer that straightens hair by chemically uncurling it. guanidine carbonate's primary functions have been for use in formulations for hair straightening, as a depilatory agent, for use in ph adjustment, and as a buffering agent. as a strong chemical base, guanidine carbonate is used by our customers as an intermediate in a broad range of application fields, including chemicals, cosmetics, detergents and microencapsulation processes. Alternative Names: Carbonic acid, compd. with guanidine (1:2); Guanidine, carbonate (2:1); Bisguanidinium carbonate; Diguanidinium carbonate; Guanidinium carbonate. Grades: ≥95%. CAS No. 593-85-1. Molecular formula: CH5N3.1/2CH2O3. Mole weight: 180.17. | |
| Guanidine thiocyanate | Guanidine thiocyanate is a freely soluble chaotropic agent routinely used for DNA/RNA extraction protocols. It can deactivate virus for study. Alternative Names: GITC; Guanidinium rhodanide; Guanidinium thiocyanate. Grades: >99%. CAS No. 593-84-0. Molecular formula: CN3H5.HSCN. Mole weight: 118.16. | |
| Guanidinium dihydrogen phosphate | Guanidinium dihydrogen phosphate. Alternative Names: guanidinium phosphate (1:1); GUANIDINUM MONOHYDROGEN PHOSPHATE; GUANIDINE DIHYDROGEN PHOSPHATE; GUANIDINE PHOSPHATE, DIBASIC; GUANIDINE PHOSPHATE, MONOBASIC; Guanidinium dihydrogen phosphate; GUPHOS; DIGUANIDINE PHOSPHATE. CAS No. 5423-22-3. Molecular formula: CH5N3.H3O4P. Mole weight: 157.06. | |
| Guanine | Guanine is a purine base which is the component of nucleotides occurring in nucleic acids. Alternative Names: 2-Amino-1,9-dihydro-6H-purin-6-one; 2-Amino-6-hydroxy-1H-purine; 2-Amino-6-hydroxypurine; 2-Aminohypoxanthine; 9H-Guanine; 2-Amino-hypoxanthine; Acyclovir Impurity B; Guanin. Grades: ≥98%. CAS No. 73-40-5. Molecular formula: C5H5N5O. Mole weight: 151.13. | |
| Guanine monohydrochloride | Guanine hydrochloride is an acid salt of Guanine. Guanine is one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Alternative Names: 6H-Purin-6-one, 2-amino-1,9-dihydro-, hydrochloride (1:1); 6H-Purin-6-one, 2-amino-1,7-dihydro-, monohydrochloride; Guanine hydrochloride; Guaninium chloride; 2-amino-3,7-dihydro-6H-purin-6-one hydrochloride. Grades: ≥95%. CAS No. 635-39-2. Molecular formula: C5H5N5O.HCl. Mole weight: 187.59. | |
| Guanosine | Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Alternative Names: 2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-β-D-ribofuranosyl-; DL-Guanosine; Guanine ribonucleoside; Guanine, 9-β-D-ribofuranosyl-; Inosine, 2-amino-; NSC 19994; Vernine; β-D-Ribofuranoside, guanine-9; ribo Guanosine. Grades: ≥95%. CAS No. 118-00-3. Molecular formula: C10H13N5O5. Mole weight: 283.24. | |
| Guanosine 3',5'-bisdiphosphate lithium salt | Regulates gene transcription; inhibits the synthesis of tRNA and rRNA. Alternative Names: Guanosine 3'-(trihydrogen diphosphate), 5'-(trihydrogen diphosphate), lithium salt; Guanosine 5'-diphosphate 3'-diphosphate lithium salt; ppGpp lithium salt; Guanosine 3',5'-bis(trihydrogen diphosphate) lithium salt; Guanosine 3'-diphosphate 5'-diphosphate lithium salt. CAS No. 57421-51-9. Molecular formula: C10H17N5O17P4·xLi. Mole weight: 603.16 (free acid). | |
| Guanosine 3',5'-cyclic monophosphate | Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'-and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. 3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine. It has a role as a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a guanyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic GMP(1-). Alternative Names: 3:5-CGMP; D-Guanosine 3',5'-cyclic monophosphate; 3',5'-cyclic GMP; 2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; Cyclic guanosine monophosphate. Grades: ≥98%. CAS No. 7665-99-8. Molecular formula: C10H12N5O7P. Mole weight: 345.21. | |
| Guanosine 3,5-cyclic monophosphate-15N5 | Guanosine 3,5-cyclic monophosphate-15N5 is a labelled analogue of Guanosine 3,5-cyclic monophosphate. Grades: > 95%. Molecular formula: C10H12[15N]5O7P. Mole weight: 350.18. | |
| Guanosine-3',5'-pentaphosphate Lithium salt | Guanosine-3',5'-pentaphosphate Lithium salt, a biochemical compound applied in biomedicine, facilitates examination of bacterial signaling pathways, their function in virulence, antibiotic resistance and biofilm formation, as well as the identification of potent antibacterial agents for enterococci and the role of guanosine pentaphosphate (pppGpp) in bacterial pathogenesis and stress response. This compound unleashes a veritable treasure trove of knowledge for our understanding of bacterial physiology-related phenomena. Alternative Names: (pppGpp); Guanosine-3'-diphosphate, 5'-triphosphate, Lithium salt; Guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) Lithium salt; Guanosine pentaphosphate Lithium salt. Grades: ≥85% by HPLC. Molecular formula: C10H18N5O20P5 (free acid). Mole weight: 683.14 (free acid). | |
| Guanosine 3'-diphosphate 5'-triphosphate | Guanosine 3'-diphosphate 5'-triphosphate is a pivotal molecule entwined in signal transduction and protein synthesis, emerging as an indispensable compound. It exert its prowess as an enthusiastic bestower of energy during translation, while adroitly orchestrating the activity of G-proteins. It assumes a role in unraveling the enigmatic dynamics of enzyme kinetics, nucleotide metabolism and the meticulous dissection of ailments synonymous to G-protein signaling cascades. Alternative Names: Guanosine-3',5'-pentaphosphate; Guanosine pentaphosphate; pppGpp; Guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate); ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxy-3-((hydroxy(phosphonooxy)phosphoryl)oxy)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; 5'-Triphosphoguanosine 3'-diphosphate. Grades: ≥95%. CAS No. 38918-96-6. Molecular formula: C10H18N5O20P5. Mole weight: 683.14. | |
| Guanosine 3'-(trihydrogen diphosphate), 5'-(trihydrogen diphosphate) | Guanosine 3'-(trihydrogen diphosphate), 5'-(trihydrogen diphosphate) is an imperative molecule aiding in the study against cancer, viral infections and neurological disorders. Alternative Names: ppGpp; Guanosine 3',5'-bisdiphosphate. Grades: 95%. CAS No. 32452-17-8. Molecular formula: C10H17N5O17P4. Mole weight: 603.16. | |
| Guanosine 5'-diphosphate disodium salt | Guanosine 5'-diphosphate disodium salt is an imperative biomolecule esteemed in the biomedical sector, exhibiting noteworthy involvement in cellular signaling and serves as a substrate for diverse nucleic acid metabolism-encompassing enzymes. Its significance is exemplified through extensive employment in research and manufacturing, enabling comprehensive exploration of G-protein coupled receptors, protein synthesis and drug discovery-related signaling pathways, as well as disease research. Alternative Names: GDP-Na2; Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}guanosine; GDP.Na2; 5'-GDP-Na2; Guanosine 5'-(trihydrogen diphosphate), disodium salt; Guanosinepyrophosphate, disodium salt; Disodium guanosine 5'-diphosphate; Guanosine-5'-diphosphoric acid disodium salt. Grades: 98%. CAS No. 7415-69-2. Molecular formula: C10H13N5Na2O11P2. Mole weight: 487.16. | |
| Guanosine 5'-monophosphate | Guanosine 5'-monophosphate is a purine ribonucleoside 5'-monophosphate having guanine as the nucleobase. It has a role as a metabolite, a biomarker, an Escherichia coli metabolite and a mouse metabolite. It is a guanosine 5'-phosphate and a purine ribonucleoside 5'-monophosphate. It is a conjugate acid of a guanosine 5'-monophosphate(2-). Guanosine 5 '-monophosphate is a guanine nucleotide containing one phosphate group, which is esterified into the sugar moiety and widely found in nature. Alternative Names: 5-Guanylic Acid; 5'-GMP; GMP; Guanidine Monophosphate; Guanosine 5'-Phosphate; Guanosine 5'-Phosphoric Acid; Guanosine Monophosphate; Guanylic Acid. Grades: ≥95%. CAS No. 85-32-5. Molecular formula: C10H14N5O8P. Mole weight: 363.22. | |
| Guanosine 5'-monophosphate disodium salt | Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). Disodium guanylate is a food additive with the E number E627. It is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG). As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides. Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats, and packaged soup. Alternative Names: Disodium guanylate; Disodium GMP; Disodium 5'-gmp; GMP disodium salt; 5'-Gmp disodium salt; Disodium guanosine-5'-monophosphate; 5'-Guanylic acid disodium salt; Sodium 5'-guanylate; Guanosine 5'-phosphate disodium salt. Grades: 98%. CAS No. 5550-12-9. Molecular formula: C10H12N5Na2O8P. Mole weight: 407.18. | |
| Guanosine-5'-O-monophosphorothioate | Guanosine-5'-O-monophosphorothioate is a critical biomolecular compound with broad utilization for studying viral infections, cancer and neurodegenerative ailments. Alternative Names: GMPS; 5'-O-thiophosphonoguanosine; 5'-GMPS. CAS No. 76310-16-2. Molecular formula: C10H14N5O7PS. Mole weight: 379.29. | |
| Guanosine 5'-triphosphate | Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. Alternative Names: D-Guanosine 5'-triphosphate; Guanosine triphosphate; Guanosine 5'-triphosphoric acid; pppG; guanosine 5'-O-(triphosphate); [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Grades: ≥98% by AX-HPLC. CAS No. 86-01-1. Molecular formula: C10H16N5O14P3. Mole weight: 523.18. | |
| Guanosine 5'-triphosphate-5'-adenosine | Guanosine 5'-triphosphate-5'-adenosine, the 5 cap analog, is a fluorescent substrate analog. Alternative Names: GpppA; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with adenosine; Adenosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with adenosine; Guanosine triphosphate, 5'→5'-ester with adenosine; Gp3A; Gp3A (dinucleotide); P1-Adenosine-5' P3-guanosine-5' triphosphate. Grades: ≥95% by HPLC. CAS No. 10527-47-6. Molecular formula: C20H27N10O17P3. Mole weight: 772.41. | |
| Guanosine-5'-triphosphate trisodium salt | Guanosine-5'-triphosphate sodium salt could be used as a phosphoryl donor in signal transduction and protein synthesis. Alternative Names: Guanosine 5'-(tetrahydrogen Triphosphate), Trisodium Salt; 5'-GTP Trisodium Salt; Trisodium 5'-GTP; GTP Trisodium Salt. Grades: ≥97% by HPLC. CAS No. 36051-31-7. Molecular formula: C10H13N5Na3O14P3. Mole weight: 589.13. | |
| Guanosine 5'-triphosphoric acid disodium salt | GTP could be used as a phosphoryl donor in signal transduction and protein synthesis. Alternative Names: GTP-Na2; Guanosine 5'-(tetrahydrogen triphosphate) sodium salt (1:2); Guanosine 5'-(tetrahydrogen triphosphate) disodium salt; 5'-GTP disodium salt; Disodium 5'-GTP; Disodium guanosine triphosphate; GTP disodium salt; Guanosine 5'-triphosphoric acid disodium salt. Grades: ≥90% by HPLC. CAS No. 56001-37-7. Molecular formula: C10H14N5Na2O14P3. Mole weight: 567.14. | |
| guanylguanidine hydrochloride | guanylguanidine hydrochloride. Alternative Names: Biguanide hydrochloride; Guanylguanidinium chloride; Imidodicarbonimidic diamide hydrochloride. CAS No. 4761-93-7. Molecular formula: C2H7N5HCl. Mole weight: 137.57. | |
| Guar gum | Guar gum is a galactomannan, commonly used in cosmetics, food products, and pharmaceutical formulations. It has also been investigated in the preparation of sustained-release matrix tablets in the place of cellulose derivatives such as methylcellulose. Alternative Names: Galactosol; guar flour; guar galactomannanum; jaguar gum; Meyprogat; Meyprodor; Meyprofin. CAS No. 9000-30-0. | |
| Guar hydroxypropyl trimonium chloride | Haarguar is a so-called cationic substance (with positive charge) obtained from guar gum. Hair Guar prevents the static charging of the hair, improves the combability of the hair and increases the creaminess in surfactant formulations such as shampoo, shower gel etc. It also has a smoothing effect on hair and skin. Uses: Hair care shampoo shower gel. Alternative Names: GUM GUAR 2-HYDROXY-3-(TRIMETHYLAMMONIO)&; cosmediaguarc261; Guar,2-hydroxy-3-trimethylammoniopropylether,chloride; Guargum,etherwith3-chloro-2-hydroxypropyltrimethylammoniumchloride; gumguar2-hydroxy-3-(trimethylammonio)-propylet; jaguarc13s; jaguarc14s; jaguar. CAS No. 65497-29-2. Molecular formula: C6H16NO2.xCl.xUnspecified. | |
| Guazatine, acetate | Guazatine, acetate. Alternative Names: Guazatine, acetate (1:x); Befran; Befran 25EC; GTA 1; Kenopel; Panoctine; Radam. CAS No. 115044-19-4. Molecular formula: C18H41N7. Mole weight: 355.60. | |
| Guluronic acid | Guluronic acid, a key constituent of alginate, primarily employed in the fabrication of wound care dressings and drug transport mechanisms, displays potent antimicrobial characteristics. Demonstrating noteworthy efficacy in chronic wound therapy, it functions adeptly as a medium for diverse pharmaceutical compounds. Grades: 98%. CAS No. 15769-56-9. Molecular formula: C6H10O7. | |
| Gum arabic | Gum Arabic is an exudate gum picked from Acacia trees (typically Acacia Senegal and Acacia Laetia) that grow in arid regions. The polysaccharide is branched with a main chain of (1-3) linked β-D-galactopyranosyl units with side chains of (1-3) β-D galactopyranosyl units joined to it by (1-6) links. The side chains are 2-5 units in length. Both the main chain and the side chains have attached units of α-L-arabinofuranosyl, α-L-rhamnopyranosyl, β-D-glucuronopyranosyl and 4-O-methyl-β-D-glucuronopyranosyl units. Uses: Decorative cosmetics. Alternative Names: Acacia ampliceps gum; Acacia dealbata gum; Acacia fragilis gum; Acacia gum; Acacia leptopetala gum; Acacia ligulata gum; Acacia meisneri gum; Acacia pruinocarpa gum; Acacia salicina gum; Acacia senegal gum; Acacia syrup; Acacia victoriae gum; Arabic Cool; Arabic gum; Arabic Gum A; Arabicum rubber; Australian gum; Cape gum; Chaargund; Char goond; Efficacia M; Fibregum; Gum acacia; Gum ovaline; Gum senegal; Gum thala; Gums, acacia; Gundar gum; Inagel Arabia Gum A; Indian gum; Instangum IRX; Instant Gum AA; Khair gum; Kordofan gum; Maklai gum; Meska; MS 1 (gum); San Arabic; Seneca gum; Senegal gum; Ticacia Gum; Tikashi Gum; Valgum; Wattle gum. CAS No. 9000-1-5. | |
| Gum guaiac | Gum guaiac. Alternative Names: Guaiac resin; Guaiacum (resin); Resins, guaiacum; Guaiacum; Guaiac; Guaiacum (the resin); Gum guaiacum; Resin guaiac; Guajacum officinale resin; Gums and Mucilages, guaiac. CAS No. 9000-29-7. | |
| Gum karaya | Gum Karaya is a vegetable gum produced from the exudate of the sterculia trees. Gum Karaya is an acidic polysaccharide composed of galactose, rhamnose and galacturonic acid. It is used in food as a thickener and emulsifier, and as a laxative and denture binder. Alternative Names: E 416; Karaya gum; Gums, karaya; Gums, sterculia; Indian tragacanth gum; Inolaxol; Kadai gum; Kadaya gum; Karaya K 5; Karayacol; Katilo gum; Kullo gum; Lamegum; Mucara; Siltex gum; Sterculia BP; Sterculia gum; Tab gum. CAS No. 9000-36-6. | |
| gum storax | gum storax. Alternative Names: STYRAX ESSENCE; STYRAX ESSENCE OLIFFAC; Asiaticstyrax; Gumstyraxhonduras; GumstyraxHonduraswhite; Liquidambarextractives; storax(balsam); Storax,balsam. CAS No. 8046-19-3. | |
| Guretolimod | Guretolimod is an agonist of Toll-like receptor 7 (TLR7) with potential immunostimulatory and antineoplastic activities. Alternative Names: Glycine, N-[[4-[[2-amino-4-[[(1S)-1-(2-hydroxyethyl)butyl]amino]-6-methyl-5-pyrimidinyl]methyl]-3-methoxyphenyl]methyl]-N-(2,2,2-trifluoroethyl)-; (S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)(2,2,2-trifluoroethyl)amino)acetic acid. Grades: ≥90%. CAS No. 1488364-57-3. Molecular formula: C24H34F3N5O4. Mole weight: 513.55. | |
| Gut restricted-7 | Gut restricted-7 is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice. Alternative Names: GR-7. Grades: 99%. CAS No. 2553218-46-3. Molecular formula: C25H40FNaO6S. Mole weight: 495.64. | |
| Guvacine Hydrochloride | Guvacine hydrochloride is a specific GABA uptake inhibitor (IC50 = 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). Guvacine may be beneficial for the treatment of neuropsychiatric disorders. Alternative Names: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 6027-91-4. Molecular formula: C6H9NO2.HCl. Mole weight: 163.6. | |
| Guvacoline hydrobromide | Guvacoline is a natural alkaloid that is found in areca nuts. Guvacoline acts as a full agonist of atrial and ileal muscarinic receptors. Alternative Names: 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, methyl ester, hydrobromide (1:1); 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, methyl ester, monohydrobromide; Nicotinic acid, 1,2,5,6-tetrahydro-, methyl ester, hydrobromide; Guvacoline monohydrobromide; Methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide; Methyl 1,2,5,6-tetrahydronicotinate hydrobromide. Grades: ≥98%. CAS No. 17210-51-4. Molecular formula: C7H11NO2.HBr. Mole weight: 222.08. | |
| GW274150 phosphate | GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM). Grades: 98%. CAS No. 438542-15-5. Molecular formula: C8H20N3O6PS. Mole weight: 317.30. | |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Alternative Names: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grades: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. | |
| GW 791343 dihydrochloride | The hydrochlorie salt form of GW791343 that is a non-competitive inhibitor of human P2X7 receptors amd it seems to show species-specific activity which is probably negative allosteric modulators of the human P2X7 receptor and the agonist of the same recep. Uses: The hydrochlorie salt form of gw791343 that is a non-competitive inhibitor of human p2x7 receptors. Alternative Names: GW791343 (dihydrochloride); 1019779-04-4; 2-((3,4-Difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride; GW 791343; GW-791343; 3075AH. Grades: >99 %. CAS No. 1019779-04-4. Molecular formula: C20H26Cl2F2N4O. Mole weight: 447.3. | |
| GW 791343 trihydrochloride | GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. Alternative Names: GW791343; GW 791343; GW-791343; 1019779-04-4. Grades: >98%. CAS No. 309712-55-8. Molecular formula: C20H24F2N4O.3HCl. Mole weight: 483.81. | |
| Gymnemagenin | Gymnemagenin is a triterpenoid isolated from Gymnema sylvestre, showing antihyperglycemic activity. Alternative Names: Olean-12-ene-3β,16β,21β,22α,23,28-hexol; (3β,4α,16β,21β,22α)-Olean-12-ene-3,16,21,22,23,28-hexol. Grades: 98%. CAS No. 22467-07-8. Molecular formula: C30H50O6. Mole weight: 506.71. | |
| Gymnema sylvestre extract | Gymnema sylvestre extract, derived from the leaves of the Gymnema sylvestre plant, is renowned for its anti-diabetic and blood sugar-regulating properties. The key active compounds in the extract are gymnemic acids, which are responsible for its ability to block the taste of sweetness and reduce sugar absorption in the intestines. Gymnema sylvestre is widely used in traditional medicine to help manage type 2 diabetes, as it can help lower blood sugar levels by increasing insulin secretion and improving insulin sensitivity. Additionally, the extract has anti-inflammatory, antioxidant, and lipid-lowering effects, which contribute to its overall benefits for metabolic health. Gymnema sylvestre is also used to support weight loss by reducing sugar cravings and helping to control appetite. It has been shown to help improve cholesterol levels and support heart health as well. Gymnema sylvestre is commonly used in supplements for blood sugar management, weight loss, and overall metabolic support. Uses: Anti-diabetic agents, kidney care agents. Alternative Names: Gudmar extract; Gymnema silvestre, ext. Grades: 95%. CAS No. 90045-47-9. | |
| gymnemic acid | gymnemic acid. Grades: 95%. CAS No. 1399-64-0. | |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Alternative Names: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. Grades: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. | |
| H 151 | H 151 is a highly potent, selective STING antagonist, which reduces TBK1 phosphorylation and suppresses human STING palmitoylation. Alternative Names: H-151; H151; Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-; N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea; N-(4-Ethylphenyl)-N'-1H-indol-3-ylurea; H 151 (pharmacological agent). Grades: ≥98%. CAS No. 941987-60-6. Molecular formula: C17H17N3O. Mole weight: 279.34. | |
| H1-7 (histone H1 phosphorylation site), PKA Substrate | H1-7 (histone H1 phosphorylation site), PKA Substrate. Alternative Names: H1-7 (histone H1 phosphorylation site), PKA Substrate; Arg-arg-lys-ala-ser-gly-pro. Grades: 95%. CAS No. 65189-70-0. Molecular formula: C31H58N14O9. Mole weight: 770.88. | |
| H 89 2HCl | H 89 2HCl is a cell permeable and potent PKA inhibitor with Ki of 48 nM in a cell-free assay, wihich is 10-fold selective for PKA than PKG, 500-fold greater selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. Alternative Names: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride. Grades: ≥98%. CAS No. 130964-39-5. Molecular formula: C20H20BrN3O2S·2HCl. Mole weight: 519.28. | |
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