BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CJ463 | CJ463 is a potent ans selective Urokinase (uPA) inhibitor, which plays a crucial role in carcinogenesis by facilitating tumor cell invasion and metastasis. It may be a novel agent for treatment of lung cancer. Uses: Cj463 may be a novel agent for treatment of lung cancer. Synonyms: CJ-463; CJ 463; CJ463. (S)-N-(4-carbamimidoylbenzyl)-3-hydroxy-2-((R)-3-hydroxy-2-((phenylmethyl)sulfonamido)propanamido)propanamide. Grade: 98%. CAS No. 600142-19-6. Molecular formula: C21H27N5O6S. Mole weight: 477.54. |  |
| CK0106023 | CK0106023 was specific inhibitor of KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons. Synonyms: CK 0106023; CK-0106023; N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide. CAS No. 336115-72-1. Molecular formula: C30H32BrClN4O2. Mole weight: 595.97. | |
| CK-119 | CK-119, a dihydropyridazino-pyridazine compound, is a potent IL-1 blocker to inhibit cell growth of fibroblast-like corneal and conjunctival cells mainly through the inhibition of DNA and RNA syntheses but not protein synthesis. Synonyms: diethyl 6-[(4-chlorophenyl)methyl]-1,4-dimethyl-5-oxopyridazino[4,5-c]pyridazine-3,4-dicarboxylate; CK-119; CK119; CK 119; UNII-AL53N923EI; GC-6119; GC 6119; GC6119. Grade: >98%. CAS No. 197917-10-5. Molecular formula: C21H23ClN4O5. Mole weight: 446.88. | |
| CK 17 | CK 17 is a interleukin-1 antagonist. It can suppress fibroblast proliferation. Synonyms: CK 17; CK17; CK-17; 5-Bromotetrahydro-5-methyl-3-phenyl-2-(phenylimino)-4H-1,3-thiazin-4-one. Grade: 98%. CAS No. 86727-00-6. Molecular formula: C17H15BrN2OS. Mole weight: 375.29. | |
| CK1-IN-1 | CK1-IN-1 is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively. Synonyms: PUN51207; Compound 1C. CAS No. 1784751-20-7. Molecular formula: C24H15F2N3. Mole weight: 383.39. | |
| CK1-IN-3 | CK1-IN-3 is a casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inflammation diseases. Synonyms: N-(6-Methoxybenzo[d]thiazol-2-yl)-2-(2-methoxyphenyl)acetamide; N-[(2E)-6-methoxy-1,3-benzothiazol-2(3H)-ylidene]-2-(2-methoxyphenyl)acetamide. CAS No. 349438-74-0. Molecular formula: C17H16N2O3S. Mole weight: 328.39. | |
| CK-2130 | CK-2130 is a bio-active imidazolone developed to treat congestive heart failure. It inhibited human platelet aggregation produced by adenosine diphosphate and sodium arachidonate. Uses: Ck-2130 is used to treat congestive heart failure. Synonyms: CK 2130; CK-2130; CK2130. 4-Ethyl-1,3-dihydro-5-[4-[(2-methyl-1H-imidazol)-1-yl]benzoyl]-2H-imidazol-2-one; CK2130; 4-Ethyl-5-[4-(2-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one. Grade: >98 %. CAS No. 101184-07-0. Molecular formula: C16H16N4O2. Mole weight: 296.33. | |
| CK-2289 | CK-2289 is an type III cyclic 3'5'-adenosine monophosphate phosphodiesterase inhibitor. It may be used in the treatment of congestive heart failure. Uses: Ck-2289 may be used in the treatment of congestive heart failure. Synonyms: CK 2289; CK-2289; CK2289. 4-[4-(1H-Imidazol-1-yl)benzoyl]-5-ethyl-1H-imidazol-2(3H)-one; 4-Ethyl-5-[4-(1H-imidazol-1-yl)benzoyl]-1H-imidazol-2(3H)-one; 2H-Imidazol-2-one,4-ethyl-1,3-dihydro-5-[4-(1H-imidazol-1-yl)benzoyl]-; 4-Ethyl-1,3-dihydro-5-[4-(1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one. Grade: >98 %. CAS No. 101183-99-7. Molecular formula: C15H14N4O2. Mole weight: 282.30. | |
| CK2/ERK8-IN-1 | CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) and ERK8. It also binds to Pim-1, HIPK2, and DYRK1A. CK2/ERK8-IN-1 induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 μM. Synonyms: TMCB; 4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid. Grade: ≥99%. CAS No. 1085822-09-8. Molecular formula: C11H9Br4N3O2. Mole weight: 534.82. | |
| CK2 inhibitor 10 | CK2 inhibitor 10 is a potent and ATP-competitive inhibitor of protein kinase (CK2; IC50 values of 32 nM and 46 nM for CK2α and CK2α' respectively). Compound 10 dose-dependently inhibits the kinases. It exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116, and breast cancer cells MCF-7. Synonyms: CK2-IN-3b; 4-(2-(4-methoxybenzamido)thiazol-5-yl)benzoic acid. Grade: 99%. CAS No. 1361229-76-6. Molecular formula: C18H14N2O4S. Mole weight: 354.38. | |
| CK2 inhibitor 2 | CK2 inhibitor 2 is a potent, selective and orally active CK2 inhibitor with favorable antiproliferative and antitumor activities. It has high selectivity for Clk2 (IC50 = 32.69 nM)/CK2 (IC50 = 0.66 nM). Synonyms: 5-(3-chlorophenylamino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide; Benzo[c][2,6]naphthyridine-8-carboxamide, 5-[(3-chlorophenyl)amino]-N-(2-hydroxyethyl)-. Grade: ≥98%. CAS No. 2641079-92-5. Molecular formula: C21H17ClN4O2. Mole weight: 392.84. | |
| CK2/PIM1-IN-1 | CK2/PIM1-IN-1 is a CK2 and PIM1 inhibitor, with IC50s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CAS No. 292640-28-9. Molecular formula: C15H9NO4S2. Mole weight: 331.37. | |
| CK 3197 | CK 3197 is a Phosphoric diester hydrolase inhibitor originated by Bayer HealthCare Pharmaceuticals. CK 3197 has hemodynamic and myocardial energetic effects. In Jan 2007, preclinical for Heart failure in USA was discontinued. Uses: Heart failure. Synonyms: CK 3197; CK-3197; CK3197. 1-benzoyl-5-(4-(4,5-dihydro-2-methyl-1H-imidazol-1-yl)benzoyl)-4-ethyl-1,3-dihydro-2H-Imidazol-2-one. Grade: 98%. CAS No. 132523-92-3. Molecular formula: C23H22N4O3. Mole weight: 402.45. | |
| CK-636 | CK-636 is an Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Synonyms: CK636; CK 636; CK-636; CK0944636; CK-0944636; CK 0944636. CAS No. 442632-72-6. Molecular formula: C16H16N2OS. Mole weight: 284.38. | |
| CK-666 | CK 666 has been found to be an inhibitor of the Arp2/3 complex and could also restrain actin polymerization. Synonyms: 442633-00-3; 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide; CK-666; CK 666; CK-0944666; 2-Fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide; 3ukr; UXRKUKRXVWJFER-UHFFFAOYSA-N; Oprea1_850670; SCHEMBL3382638; CHEBI:78843; DTXSID70343330; 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)-ethyl]-benzamide; CK666; NSC821559; STK766770; AKOS001725056; CK 666?; NSC-821559; NCGC00370920-01; AS-82972; CK-666, >=98% (HPLC), powder; DA-62359; HY-16926; CS-0012973; F81773; SR-01000536526; SR-01000536526-1; Q27147993; Z1038843750; CKH. Grade: ≥99% by HPLC. CAS No. 442633-00-3. Molecular formula: C18H17FN2O. Mole weight: 296.34. | |
| CK 683A | CK 683A is a bio-active chemical,but no detailed information has been published yet. Synonyms: CK 683A; CK683A; CK-683A. 1,7-Bis((1-adamantyl)carbamylguanidino)-4-methyl-4-azaheptane. Grade: 98%. CAS No. 83539-21-3. Molecular formula: C32H57N9O5S. Mole weight: 679.92. | |
| CK 869 | CK 869 has been found to inhibit actin polymerization as well as human and bovine actin-related protein 2/3 (Arp2/3) complex. Synonyms: CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869; 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone. Grade: ≥98% by HPLC. CAS No. 388592-44-7. Molecular formula: C17H16BrNO3S. Mole weight: 394.28. | |
| CKD-516 | This active molecular is a tubulin polymerisation inhibitor which is applicated for solid cancer treatment. CKD-516 disruptes tubulin of the endothelial cytoskeleton selectively. In Jun 2012, a South Korea company, Chong Kun Dang initiated enrolment in a phase I trial for solid tumours treatment in South Korea. In Dec 2014, Phase-I clinical trials in Solid tumours in South Korea was on going. Uses: Solid tumours. Synonyms: CKD-516 HCl; CKD 516 HCl; CKD516 HCl; (2S)-2-amino-3-methyl-N-[4-[3-(1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol-2-yl]butanamide; hydrochloride; 1188371-47-2 (free base). Grade: 98%. CAS No. 1188371-47-2. Molecular formula: C26H28N6O5S. Mole weight: 536.6. | |
| CKD-516 HCl | CKD-516 is tubulin inhibitor for solid cancer, which was initiated phase 1 trial in Korea in 2010. CKD-516 selectively disrupted tubulin component of the endothelial cytoskeleton. Serial DCE-MRI showed a significant decrease in K-trans and IAUGC parameters from baseline at 4 h (39.9 % in K-trans; -45.0 % in IAUGC) and at 24 h (-32.2 % in K-trans; -36.5 % in IAUGC), and a significant recovery at 48 h (22.9 % in K-trans; 34.8 % in IAUGC) following administration of CKD-516 at a 0.7-mg/kg dose. When the tumors were stratified according to the initial K-trans value of 0.1, tumors with a high K-trans?>?0.1 which was indicative of having well-developed pre-existing vessels, showed greater reduction in K-trans and IAUGC values. On histologic examination, the degree of necrosis of treated tumors was significantly greater than that of untreated tumors. In summary, CKD-516 is an effective VDA which results in rapid vascular shutdown by targeting the tubulin component of tumor vessels and thus leads to necrosis. Synonyms: Valecobulin hydrochloride; CKD516 hydrochloride; CKD 516 hydrochloride. CAS No. 1240321-53-2. Molecular formula: C26H29ClN6O5S. Mole weight: 573.07. | |
| CKI 7 dihydrochloride | CKI 7 is a CK1 inhibitor, and also inhibits SGK, S6K1 and MSK1. In combination with SB 431542, CKI 7 was shown to induce retinal cell differentiation from human ESCs and iPSCs. Synonyms: CKI-7 dihydrochloride; N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride. Grade: >98%. CAS No. 1177141-67-1. Molecular formula: C11H14Cl3N3O2S. Mole weight: 358.67. | |
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