BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CI-898 hydrochloride | CI-898 is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). The presence of the cofactor NADPH enhances bind of CI-898 and DHFR. CI-898 inhibits growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also inhibits the growth of S. faecalis and S. aureus when used at concentrations less than 0.25 μg/ml. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine in mice with advanced stage P338 leukemia. Synonyms: Trimetrexate; CI 898 trihydrochloride; Trimetrexate trihydrochloride; TMTX. Grade: ≥98%. CAS No. 1658520-97-8. Molecular formula: C19H23N5O3·3HCl. Mole weight: 478.80. |  |
| CI 924 | CI 924 is hypolipidemic agent. It can elevate anti-atherogenic HDL and lower VLDL. Uses: Hypolipidemic agent. Synonyms: CI 924; CI924; CI-924; EINECS 279-174-7. 5,5'-((1,1'-Biphenyl)-2,5-diylbis(oxy))bis(2,2-dimethylpentanoic acid). Grade: 98%. CAS No. 79520-77-7. Molecular formula: C26H34O6. Mole weight: 442.54. | |
| CI-949 | CI-949 is an allergic mediator release inhibitor. It inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively. Synonyms: 5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide. CAS No. 104961-19-5. Molecular formula: C20H20N6O3. Mole weight: 392.41. | |
| CI 951 | CI 951 is a dihydronaphthyridine Ca2+ channel antagonist and it may be applicated for the treatment of focal cerebral ischemia. CI 951 has potential as a cerebral vasodilator. Uses: Focal cerebral ischemia. Synonyms: CI 951; CI-951; CI951. 1,6-Naphthyridine-3-carboxylic acid, 1,4-dihydro-2-methyl-5-(1-methylethoxy)-4-(2-(trifluoromethyl)phenyl)-, ethyl ester. Grade: 98%. CAS No. 126661-07-2. Molecular formula: C22H23F3N2O3. Mole weight: 420.42. | |
| CI-959 free acid | CI-959 free acid is an orally effective inhibitor of cellular activation in both in vitro and animal models. It has antiallergic and anti-inflammatory properties. Uses: Ci-959 free acid has antiallergic and anti-inflammatory properties. Synonyms: CI-959 free acid; CI 959 free acid; CI959 free acid; UNII-Y8M8A93SU8. 3-(1-Methylethoxy)-5-methoxy-N-(1H-tetrazol-5-yl)benzo[b]thiophene-2-carboxamide; 5-Methoxy-3-isopropoxy-N-(1H-tetrazole-5-yl)benzo[b]thiophene-2-carboxamide; Benzo[b]thiophene-2-carboxamide,5-methoxy-3-(1-methylethoxy)-N-2H-tetrazol-5-yl-. Grade: >98 %. CAS No. 104795-66-6. Molecular formula: C14H15N5O3S. Mole weight: 333.37. | |
| CI966 | CI966 is a highly potent and selective blocker of the GABA transporter 1 (GAT-1) with IC50 value of 0.26 μM acting as a central nervous system depressant. It has potential as a potential anxiolytic, anticonvulsant and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed. In a phase I human clinical trial it was developed for the treatment of epilepsy. Uses: Ci966 it has potential as a potential anxiolytic, anticonvulsant and neuroprotective therapeutic. it was developed for the treatment of epilepsy. Synonyms: CI-966; CI 966; CI966; CHEMBL77287; CHEMBL542207; 1-(2-(Bis(4-(trifluoromethyl)phenyl)methox)ethyl)-1,2,5,6-tetrahydro-3-pyrdinecarboxylic acid. Grade: >98%. CAS No. 110283-79-9. Molecular formula: C23H21F6NO3. Mole weight: 473.41. | |
| CI 966 hydrochloride | The hydrochloride salt form of CI 966, which is an inhibitor of the GABA transporter and could be used as anticonvulsive as well as neuroprotective agent. Synonyms: CI 966 hydrochloride; CI966 hydrochloride; CI-966 hydrochloride; 1-[2-[bis[4-(Trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride. Grade: ≥98% by HPLC. CAS No. 110283-66-4. Molecular formula: C23H21F6NO3.HCl. Mole weight: 509.87. | |
| CI 969 | This active molecular is a muscarinic agonist agent. Synonyms: CI 969; CI969; CI-969; (Z)-1-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)ethanone O-acetyl oxime hydrochloride. Grade: 98%. CAS No. 113590-49-1. Molecular formula: C10H17ClN2O2. Mole weight: 232.71. | |
| CI 972 | This active molecular is a potent purine nucleoside phosphorylase inhibitor and a T cell-selective immunosuppressive agent. CI-972 inhibited proliferation of human MOLT-4 (T cell) and not MGL-8 (B cell) lymphoblasts with respective IC50s of 3.0 and greater than 50 microM when tested with 10 microM 2'-deoxyguanosine. In Apr 1996, Immunological Disorders section added to drug profile and Immunological disorders in USA was discontinued. Uses: Immunological disorders; transplant rejection. Synonyms: CI 972; CI972; CI-972. 4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride. Grade: 98%. CAS No. 115787-68-3. Molecular formula: C11H12ClN5OS. Mole weight: 297.76. | |
| CI 976 | CI 976 has been found to be a selective inhibitor of Acyl-coenzyme A and could probably lower non-high density lipoprotein (HDL)-cholesterol. Uses: Enzyme inhibitors. Synonyms: CI 976; CI-976; CI976; 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide. Grade: ≥98% by HPLC. CAS No. 114289-47-3. Molecular formula: C23H39NO4. Mole weight: 393.57. | |
| CI 986 | CI 986 is a nonulcerogenic anti-inflammatory agent as a Arachidonic acid inhibitor originated by Pfizer. In 1994, Preclinical for Inflammation was discontinued. Uses: Inflammation. Synonyms: CI 986; CI-986; CI986. 2-hydroxy-N,N,N-trimethylethanaminium 2,6-di-tert-butyl-4-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)phenolate. Grade: 98%. CAS No. 130116-16-4. Molecular formula: C21H35N3O2S2. Mole weight: 425.66. | |
| CI 988 | CI 988 has been found to be a CCK-2 receptor antagonist and could exhibit anxiolytic activity. Uses: Anti-anxiety agents. Synonyms: CI 988; CI988; CI-988; PD 134308, PD-134,308, PD-134308; 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid. Grade: ≥99% by HPLC. CAS No. 130332-27-3. Molecular formula: C35H42N4O6. Mole weight: 614.73. | |
| CI 992 | CI 992 is a renin inhibitor originated by Pfizer. Preclinical trials for Hypertension in USA was discontinued in 1994. Uses: Hypertension. Synonyms: CI 992; CI992; CI-992. N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide; [1S-(1R*,2S*,3R*)]- N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide; PD 134672; PD134672; PD-134672. Grade: 98%. CAS No. 135704-06-2. Molecular formula: C33H52N6O7S2. Mole weight: 708.94. | |
| CIAC001 | CIAC001 is a novel inhibitor of Pyruvate Kinase with anti-neuroinflammatory activity. CIAC001 inhibits LPS-induced proinflammatory nitric oxide (NO) production and protects immunologically active BV-2 cells (IC50=2.5 μM). Synonyms: (1'R,2'R)-4-(1-(2H-1,2,3-Triazol-2-yl)ethyl)-5'-methyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-2,6-diol. CAS No. 2649154-82-3. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| Cianopramine hydrochloride | Cianopramine hydrochloride is the hydrochloride form of Cianopramine, which acts as a serotonin reuptake inhibitor and weak serotonin receptor antagonist. It is a tricyclic antidepressant and used for the treatment of depression. Uses: Cianopramine hydrochloride is a tricyclic antidepressant and used for the treatment of depression. Synonyms: 11-(3-Dimethylaminopropyl)-5,6-dihydrobenzo(b)(1)benzazepine-9-carbonitrile hydrochloride; Cianopramine HCl; Ro 112465 hydrochloride; Ro-11-2465 hydrochloride. Grade: 98%. CAS No. 66834-20-6. Molecular formula: C20H24ClN3. Mole weight: 341.88. | |
| Cibacron Blue | Cibacron Blue is a renowned dye extensively employed in the biomedical sector exhibiting remarkable utility in the researchs of affinity chromatography and protein purification. Its distinct affinity towards biological entities, namely enzymes, proteins and biomolecules, renders it an invaluable tool in the research of a wide range of ailments encompassing cancer, diabetes and infectious diseases. Synonyms: Cibacron blue 3GA; 1-amino-4-[4-[[4-chloro-6-(2-sulfoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid. CAS No. 84166-13-2. Molecular formula: C29H20ClN7O11S3. Mole weight: 774.16. | |
| Cibenzoline | Cibenzoline is an anti- arrhythmic drug, by inhibiting myocardial cell Na + influx and producing antiarrhythmic effects. Uses: Anti-arrhythmia agents. Synonyms: 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole. Grade: > 95%. CAS No. 53267-01-9. Molecular formula: C18H18N2. Mole weight: 262.36. | |
| Cibenzoline Impurity (N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide) | N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide is an intermediate in the synthesis of Cibenzoline (Cifenline). Synonyms: 109546-07-8; N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamideN-(2-AMINOETHYL)-2,2-DIPHENYLCYCLOPROPANE-1-CARBOXAMIDE; Cibenzoline Impurity (N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide); DTXSID40746995. Grade: > 95%. CAS No. 109546-07-8. Molecular formula: C18H20N2O. Mole weight: 280.37. | |
| Cibisatamab | Cibisatamab is an anti-carcinoembryonic antigen (CEA) and anti-CD3 bispecific monoclonal antibody used for cancer therapy. Cibisatamab binds to both T cells and CEA-expressing tumor cells, which cross-links the T cells with the tumor cells. Synonyms: CEA-TCB. CAS No. 1855925-27-7. | |
| Cicaprost | Cicaprost, a prostacyclin receptor (IP) agonist, is the most potent endogenous vasodilator, affecting systemic and pulmonary circulation. Uses: Antineoplastic agents. Synonyms: Acetic acid, 2-[2-[(2E,3aS,4S,5R,6aS)-hexahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiyn-1-yl]-2(1H)-pentalenylidene]ethoxy]-; 2-[2-[(2E,3aS,4S,5R,6aS)-Hexahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiyn-1-yl]-2(1H)-pentalenylidene]ethoxy]acetic acid; Acetic acid, [(2E)-2-[(3aS,4S,5R,6aS)-hexahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiynyl]-2(1H)-pentalenylidene]ethoxy]-; Acetic acid, [2-[hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1,6-nonadiynyl)-2(1H)-pentalenylidene]ethoxy]-, [3aS-[2E,3aα,4α(3R*,4R*),5β,6aα]]-; ZK 96480; ZK-96480; ZK96480. Grade: ≥95%. CAS No. 94079-80-8. Molecular formula: C22H30O5. Mole weight: 374.47. | |
| Ciclesonide | Ciclesonide, a glucocorticoid, could be useful in the treatment of sorts of airway inflammatory diseases like allergic rhinitis. Uses: Ciclesonide could be useful in the treatment of sorts of airway inflammatory diseases like allergic rhinitis. Synonyms: (r)-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate; (R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate; Cicles. Grade: 98%. CAS No. 126544-47-6. Molecular formula: C32H44O7. Mole weight: 540.69. | |
| Ciclindole | Ciclindole is an antipsychotic and acts as a D2 receptor antagonist. Synonyms: cyclindole; 2,3,4,9-Tetrahydro-N,N-dimethyl-1H-carbazol-3-amine. Grade: 95%. CAS No. 32211-97-5. Molecular formula: C14H18N2. Mole weight: 214.31. | |
| Ciclopirox | Ciclopirox olamine (used in preparations called Batrafen, Loprox, Rejuvenail, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. Synonyms: Ciclopirox. Grade: >98%. CAS No. 29342-05-0. Molecular formula: C12H17NO2. Mole weight: 207.27. | |
| Ciclopirox β-D-Glucuronide | Ciclopirox β-D-Glucuronide is a metabolite of Ciclopirox. Synonyms: 1-[(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]-1-deoxy-β-D-glucopyranuronic Acid. Grade: > 95%. CAS No. 79419-54-8. Molecular formula: C18H25NO8. Mole weight: 383.40. | |
| Ciclopirox EP Impurity C | An impurity of Ciclopirox. Ciclopirox is an antifungal medication used to treat various fungal skin infections, including athlete's foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis), and pityriasis versicolor (tinea versicolor). It works by inhibiting fungal growth and disrupting the integrity of fungal cell membranes. Synonyms: 6-Cyclohexyl-4-methylpyridin-2(1H)-one; N-Deshydroxy Ciclopirox; Ciclopirox olamine EP Impurity C; Ciclopirox Impurity C; 6-Cyclohexyl-4-methyl-2(1H)-pyridinone; Ciclopirox olamine impurity C [EP]. Grade: 95%. CAS No. 67587-24-0. Molecular formula: C12H17NO. Mole weight: 191.27. | |
| Ciclopirox ethanolamine | Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator. Uses: Antifungal agents. Synonyms: Ciclopirox olamine; 41621-49-2; Ciclopirox ethanolamine; ciclopiroxolamine; Batrafen; Micoxolamina; Brumixol; Mycoster; Ciclopiroxolamin; Ciclochem; Dafnegin; Ciclopirox (olamine); HOE 296; Ciclopirox ethanolamine salt (1:1); HOE-296; UNII-50MD4SB4AP; EINECS 255-464-9; 50MD4SB4AP; NSC 336278; NSC-336278; DTXSID6045583; RV4104A; MFCD00078997; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt; Ciclobirox Olamine; 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one compound with 2-aminoethanol (1:1); MLS003170863; 2-aminoethanol; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one. Grade: >98%. CAS No. 41621-49-2. Molecular formula: C12H17NO2.C2H7NO. Mole weight: 268.35. | |
| Cicloprofen | Cicloprofen is a cell division cycle 7-related protein kinase (human) inhibitor. Synonyms: SQ 20824; 2-Fluoren-2-ylpropionic acid; alpha-Methylfluorene-2-acetic acid. Grade: 95%. CAS No. 36950-96-6. Molecular formula: C16H14O2. Mole weight: 238.28. | |
| Cicloprolol hydrochloride | Cicloprolol hydrochloride is the hydrochloride form of Cicloprolol which is a partial β 1-adrenoceptor agonist. Synonyms: Cicloprolol (hydrochloride); Cicloprolol HCl; (+-)-1-(p-(2-(Cyclopropylmethoxy)ethoxy)phenoxy)-3-(isopropylamino)-2-propanol hydrochloride. CAS No. 63686-79-3. Molecular formula: C18H30ClNO4. Mole weight: 359.89. | |
| Cicortonide | Cicortonide is a corticosteroid with anti-inflammatory activity. CAS No. 19705-61-4. Molecular formula: C29H37ClFNO7. Mole weight: 566.063. | |
| CID 1067700 | CID 1067700 is a Rab7 GTPase inhibitor exhibiting significant inhibitory potency against Rab7 nucleotide binding with nanomolar inhibitor (Ki) values and an inhibitory response of ≥97% for BODIPY-GTP and BODIPYGDP binding (Ki values 13 nM and 19 nM, and EC50 values 11 and 21 nM, respectively). CID 1067700 is a competitive guanine nucleotide binding inhibitor. Synonyms: CID 1067700; CID1067700; 2-(3-benzoylthioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid; MLS000673908; ML282; SMR000297947; CID-1067700. Grade: 99%. CAS No. 314042-01-8. Molecular formula: C18H18N2O4S2. Mole weight: 390.48. | |
| CID1172084 | CID1172084 is a novel high-potent and selective GPR55 agonist that interacts with cannabinoid receptors. Synonyms: CID 1172084; CID-1172084. CAS No. 459848-10-3. Molecular formula: C23H18FN5O2S2. Mole weight: 479.55. | |
| CID1231538 | CID1231538, a benzothiazole analogue, is a potent GPR35 antagonist (IC50=0.55 μM). Synonyms: MLS000544709; SMR000161135; N-(2-((4-Chlorobenzyl)thio)benzo[d]thiazol-6-yl)-2-(morpholine-4-carbonyl)benzamide. Grade: 97%. CAS No. 354126-20-8. Molecular formula: C26H22ClN3O3S2. Mole weight: 524.05. | |
| CID 1375606 | CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively). GPR27 is characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. Synonyms: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide; 2,4-Dichloro-N-(4-(phenylcarbamoyl)phenyl)benzamide. Grade: ≥98% by HPLC. CAS No. 313493-80-0. Molecular formula: C20H14Cl2N2O2. Mole weight: 385.24. | |
| CID 16020046 | CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist, which inhibitsGPR55 constitutive activity. It reduced LPI-induced wound healing in primary human lung microvascular endothelial cells and reversed LPI-inhibited platelet aggregation. Synonyms: CID16020046; CID-16020046; CID 16020046. Grade: >98%. CAS No. 834903-43-4. Molecular formula: C25H19N3O4. Mole weight: 425.44. | |
| CID1792197 | CID1792197 is a GPR55 agonist with an EC50 value of 0.11 μM. CAS No. 1164479-69-9. Molecular formula: C24H23N3O4S2. Mole weight: 481.59. | |
| CID-2011756 | CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 μM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 μM, respectively). CID 2011756 also has antitumor activity. Synonyms: CID2011756; CID 2011756; CID-2011756. CAS No. 638156-11-3. Molecular formula: C22H21ClN2O3. Mole weight: 396.871. | |
| CID-25014542 | CID-25014542 is a Raf kinase inhibitor. Synonyms: CID-25014542; CID25014542; CID 25014542. 5-Chloro-3-(3,5-dibromo-4-hydroxybenzylidene)indolin-2-one; (3Z)-5-chloro-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-1H-indol-2-one. CAS No. 220904-99-4. Molecular formula: C15H8Br2ClNO2. Mole weight: 429.492. | |
| CID 2745687 | CID 2745687 has been found to be a GPR35 antagonist and could probably be used in immune or gastrointestinal system regulation. Synonyms: CID2745687; CID-2745687; 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester. Grade: ≥98% by HPLC. CAS No. 264233-05-8. Molecular formula: C17H19F2N5O2S. Mole weight: 395.43. | |
| CID-2818500 | CID-2818500 is an inhibitor of protein arginine methyltransferase 1 (PRMT1). It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, when used at concentrations of 10 and 100 μM. Synonyms: α-Nitrostilbene; NSC 385; 1,1'-(1-nitro-1,2-ethenediyl)bis-benzene. Grade: ≥98%. CAS No. 1215-07-2. Molecular formula: C14H11NO2. Mole weight: 225.2. | |
| CID-2858522 | CID-2858522 selectively inhibits the NF-κB pathway induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. Synonyms: CID2858522; CID-2858522; CID 2858522; ML029; ML-029; ML 029. Grade: >98%. CAS No. 758679-97-9. Molecular formula: C28H39N3O3. Mole weight: 465.63. | |
| CID44216842 | CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. Synonyms: Cdc42-IN-1. CAS No. 1222513-26-9. Molecular formula: C22H20BrN3O3S. Mole weight: 486.38. | |
| CID5721353 | CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove. Synonyms: 2-((5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanedioic acid; CID5721353; CID-5721353; CID 5721353; BCL6 Inhibitor, 79-6. CAS No. 301356-95-6. Molecular formula: C15H9BrN2O6S2. Mole weight: 457.26. | |
| CID 5951923 | CID 5951923 has been found to be a KLF-5 expression inhibitor and could exhibit selective activity against colon cancer cells. Synonyms: CID-5951923; CID 5951923; CID5951923; 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate. Grade: ≥97% by HPLC. CAS No. 749872-43-3. Molecular formula: C16H18N2O7S. Mole weight: 382.39. | |
| CID-755673 | CID-755673 is a selective protein kinase D (PKD) inhibitor. CID-755673 was identified from the National Institutes of Health small molecule repository library of 196,173 compounds. In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential. Synonyms: CID-755673; CID 755673; CID755673. Grade: 0.98. CAS No. 521937-07-5. Molecular formula: C12H11NO3. Mole weight: 217.224. | |
| CID-797718 | A novel protein kinase D inhibitor that causes potent arrest in prostate cancer cell growth and motility. Synonyms: CID 797718; CID797718. Grade: >98%. CAS No. 370586-05-3. Molecular formula: C12H11NO3. Mole weight: 217.22. | |
| Cidofovir | Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. Synonyms: Vistide; HPMPC; (S)-HPMPC; Cidofovir anhydrous; GS-504; GS 504; GS504; (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine; (S)-(((1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid. Grade: ≥98% by HPLC. CAS No. 113852-37-2. Molecular formula: C8H14N3O6P. Mole weight: 279.19. | |
| Cidofovir Diphosphate | Cidofovir Diphosphate - a powerful antiviral agent - is essential in combating cytomegalovirus (CMV) retinitis in AIDS patients. This innovative compound can also effectively treat other herpesvirus infections, including herpes simplex virus (HSV) and varicella-zoster virus (VZV). Its mechanism of action involves the inhibition of viral DNA synthesis and the suppression of viral particle replication, mitigating the continued spread of the virus. Synonyms: (S)-1-(3-Hydroxy-2-phosphonylmethoxyproypl)Cytosine-Diphosphate. Grade: ≥90% by AX-HPLC. Molecular formula: C8H16N3O12P3. Mole weight: 439.10. | |
| Ciglitazone | Ciglitazone is a selective agonist at peroxisome proliferator-activated receptor γ (PPARγ) with an EC50 value of 3 μM in vitro. It is at least 33-fold selective over PPARα and δ. It shows antihyperglycemic activity in genetically obese C57 B1/6 ob/ob mice and is used as an antihyperglycemic agent. Uses: Hypoglycemic agents. Synonyms: ADD 3878; ADD-3878; ADD3878; Ciglitazona; U 63287; U-63287; U63287; ADD 3878; ADD-3878; ADD3878; (+/-)-5-[4-(1-methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione; ADD-3878; 5-[[4-[(1-Methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione. Grade: ≥99% by HPLC. CAS No. 74772-77-3. Molecular formula: C18H23NO3S. Mole weight: 333.44. | |
| Cilastatin | Cilastatin can prevent renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. It can be used as antibacterial adjunct. Uses: Antibacterial adjunct. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid; MK-791; MK 791; MK791. Grade: >95%. CAS No. 82009-34-5. Molecular formula: C16H26N2O5S. Mole weight: 358.45. | |
| Cilastatin Ammonium Salt | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grade: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
| Cilastatin sodium | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z)?-7-[[(2R)?-2-Amino-2-carboxyethyl]?thio]?-2-[[[(1S)?-2,?2-dimethylcyclopropyl]?carbonyl]?amino]?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grade: 98%. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
| Cilazapril | Cilazapril is a very potent and highly effective angiotensin-converting enzyme inhibitor (ACE inhibitor). It is used for the treatment of hypertension and congestive heart failure. lt is a monoethyl ester. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat by non-specific esterases. It is known that the diacid form is more potent. It has been listed. Uses: Cilazapri is used for the treatment of hypertension and congestive heart failure. Synonyms: Cilazapril; Ro 34-2848; Ro-34-2848; Ro34-2848. 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate; 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-; 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-; Ro 31-2848; (1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; Inhibace; Vascace; Cilazaprilum; (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid. Grade: >98%. CAS No. 88768-40-5. Molecular formula: C22H31N3O5. Mole weight: 417.50. | |
| Cilazaprilat | Cilazaprilat is the active metabolite of Cilazapril. It is an ACE inhibitor. Cilazaprilat shows antihypertensive activity. Uses: Antihypertensive agents. Synonyms: (1S,9S)-9-[[(1S)-1-Carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid; Ro 31-3113. Grade: > 95%. CAS No. 90139-06-3. Molecular formula: C20H27N3O5. Mole weight: 389.45. | |
| Cilazapril Monohydrate | Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. Uses: Angiotensin-converting enzyme inhibitors. Synonyms: CILAZAPRIL MONOHYDRATE; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-, monohydrate, (1S-(1alpha,9alpha(R*)))-; 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, octahydro-9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-10-oxo-, hydrate, (1S-(1-alpha,9-alpha(R*)))-; MS-27800; D01069; Q27252108; (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate; (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid--water (1/1); 6H-PYRIDAZINO(1,2-A)(1,2)DIAZEPINE-1-CARBOXYLIC ACID, 9-((1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)OCTAHYDRO-10-OXO-, MONOHYDRATE, (1S-(1.ALPHA.,9.ALPHA.A(R*)))-. Grade: >98%. CAS No. 92077-78-6. Molecular formula: C22H33N3O6. Mole weight: 435.51. | |
| Ciliobrevin A | Ciliobrevin A is a Hedgehog (Hh) pathway inhibitor that blocks Hh pathway activation and decreases Smo ciliary accumulation in a constitutively active Hh cell line. It perturbs primary cilia formation, leads to disruption of Gli1/Gli2 activity, and suppresses primary cilia-related protein intraflagellar transport protein IFT88 expression. It inhibits cell proliferation, invasion and migration ability in human chondrosarcoma. Synonyms: HPI-4; Hedgehog Pathway Inhibitor 4; (E)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile. Grade: >98%. CAS No. 302803-72-1. Molecular formula: C17H9Cl2N3O2. Mole weight: 358.18. | |
| Ciliobrevin D | Ciliobrevin D is an inhibitor of dynein ATPase activity that prevents the cycling activity of the motor protein. It inhibits the bi-directional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches. CAS No. 1370554-01-0. Molecular formula: C17H8Cl3N3O2. Mole weight: 392.62. | |
| Cilobradine hydrochloride | Cilobradine hydrochloride, also called as DK-AH 269, a benzazepinone derivative, is an HCN Channel blocker that might be beneficial in the treatment of cardiovascular diseases, e.g. ischemia. Synonyms: 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one; hydrochloride 1,3,4,5-tetrahydro-7,8-dimethoxy-3-((1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl)methyl)-2H-3-benzazepin-2-one hydrochloride D. CAS No. 186097-54-1. Molecular formula: C28H39ClN2O5. Mole weight: 519.07. | |
| Cilofexor | Cilofexor is a farnesoid X receptor (FXR) agonist. Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Synonyms: 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic acid. Grade: ≥98%. CAS No. 1418274-28-8. Molecular formula: C28H22Cl3N3O5. Mole weight: 586.9. | |
| Cilomilast | Selective phosphodiesterase 4 (PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease. Uses: Phosphodiesterase 4 inhibitors. Synonyms: SB 207499; SB-207499; SB207499. Cilomilast; Ariflo. Grade: 0.98. CAS No. 153259-65-5. Molecular formula: C20H25NO4. Mole weight: 343.423. | |
| Cilomilast-d5 | An isotope labelled of Cilomilast. Cilomilast is a selective phosphodiesterase-4 inhibitor and can be used for the treatment of respiratory disorders. Grade: 95% by HPLC; 98% atom D. Molecular formula: C20H20D5NO4. Mole weight: 348.45. | |
| Cilostamide | Cilostamide is a selective and specific inhibitor of type III phosphodiesterase (PDE3). It shows moderate selectivity for PDE3A isozyme and PDE3B. It increases intracellular cAMP and inhibits ADP-induced platelet aggregation. It has an antithrombotic effect. Uses: Phosphodiesterase inhibitors. Synonyms: Cilostamide; OPC 3689; OPC-3689; OPC3689; N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide; 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one. CAS No. 68550-75-4. Molecular formula: C20H26N2O3. Mole weight: 342.44. | |
| Cilostazol | Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake. Uses: Bronchodilator agents. Synonyms: AT2266; CI919; Pd107779; NSC629661; AT 2266; CI 919; Pd 107779; NSC 629661; AT-2266; CI-919; Pd-107779; NSC-629661. Grade: >98%. CAS No. 73963-72-1. Molecular formula: C20H27N5O2. Mole weight: 369.46. | |
| Cilostazol related compound C | 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone, is an impurity of Cilostazol, a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Synonyms: 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butyl]-3,4-dihydro-2(1H)-quinolinone. Grade: > 95%. CAS No. 865792-18-3. Molecular formula: C31H45N9O2. Mole weight: 575.75. | |
| Ciluprevir | Ciluprevir is used experimentally in the treatment of hepatitis C. It is manufactured by Boehringer Ingelheim Pharma GmbH & Co. kg and developed under the research code of BILN-2061. It is targeted against NS2-3 protease. Synonyms: BILN 2061; BILN-2061; BILN2061; BILN-2061ZW; BILN2061ZW; BILN 2061ZW; Ciluprevir. Grade: >98%. CAS No. 300832-84-2. Molecular formula: C40H50N6O8S. Mole weight: 774.93. | |
| CIM 0216 | CIM 0216 has been found to be a selective TRPM3 agonist and could stimulate the release of insulin from pancreatic islet cells. Synonyms: CIM-0216; CIM 0216; CIM0216; 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide. Grade: ≥98% by HPLC. CAS No. 1031496-06-6. Molecular formula: C21H21N3O2. Mole weight: 347.41. | |
| Cimaterol | Cimaterol is a β-adrenergic agonist, related to Clenbuterol and Mabuterol. It is also a repartitioning agent. Uses: Adrenergic beta-agonists. Synonyms: Cimater; 2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile; CL 263780; Cimaterolum. Grade: 98%. CAS No. 54239-37-1. Molecular formula: C12H17N3O. Mole weight: 219.28. | |
| Cimbuterol | Cimbuterol is a β-adrenergic agonist. Synonyms: 2-Amino-5-(2-tert-butylamino-1-hydroxyethyl)-benzonitrile. CAS No. 54239-39-3. Molecular formula: C13H19N3O. Mole weight: 233.315. | |
| Cimdelirsen | Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense molecule designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients. Synonyms: ISIS 766720; ISIS-766720; ISIS766720; IONIS-GHR-LRx; all-P-ambo-5'-O-(28-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis{[3-({6-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]hex-yl}amino)-3-oxopropoxy]methyl}-1-hydroxy-1,10,14,21-tetraoxo-2,18-dioxa-9,15,22-triaza-1λ5-phosphaoctacosan-1-yl)-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytid. CAS No. 2131025-82-4. | |
| Cimetidine | Cimetidine, a histamine congener, competitively inhibits histamine binding to histamine H2 receptors. Uses: Adjuvants, immunologic; analgesics, non-narcotic; anti-ulcer agents; enzyme inhibitors; histamine h2 antagonists. Synonyms: SKF-92334; SKF 92334; SKF92334. Grade: >98%. CAS No. 51481-61-9. Molecular formula: C10H16N6S. Mole weight: 252.34. | |
| Cimetidine EP Impurity B | Cimetidine EP Impurity B is an impurity of Cimetidine, a pharmacological agent categorized under the esteemed H2-receptor antagonist lineage. The paramount significance of Cimetidine lies in its prescription dominion, predominantly directed towards efficaciously treating ailments encompassing gastroesophageal reflux maladies, peptic ulcers and analogous afflictions permeating the gastrointestinal domain. Synonyms: Methyl 3-cyano-1-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl]ethyl]-carbamimidate. Grade: > 95%. CAS No. 138035-55-9. Molecular formula: C10H15N5OS. Mole weight: 253.32. | |
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