BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CH-401Na | CH-401Na is a bio-active chemical compound. Synonyms: CH 401Na; CH-401-Na; CH401-Na; 1-(2-Hydroxy-4-(3-sulfopropyloxy)phenyl)-3-(3-hydroxy-4-methoxyphenyl)-1-propanone sodium salt. Grade: 98%. CAS No. 59881-19-5. Molecular formula: C19H21NaO8S. Mole weight: 432.42. |  |
| CH 402 | CH 402 can inhibit lipid peroxidation. Synonyms: CH 402; CH402; CH-402. 4-Quinolinemethanesulfonic acid, 1,2-dihydro-2,2-dimethyl-, monosodium salt. Grade: 98%. CAS No. 75903-70-7. Molecular formula: C12H15NO3S.Na. Mole weight: 275.30. | |
| CH5015765 | CH5015765 is a novel potent and selective HSP90 inhibitor. CH5015765, which showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models. Synonyms: CH-5015765; CH 5015765; 4-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-6-(methylthio)-1,3,5-triazin-2-amine. Grade: 98%. CAS No. 959766-47-3. Molecular formula: C16H13ClN4OS. Mole weight: 344.82. | |
| CH5132799 | CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3K; (IC(50)=0.014 uM). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. Synonyms: CH5132799; CH-5132799; CH 5132799; PA-799; PA799; PA-799. CAS No. 1007207-67-1. Molecular formula: C15H19N7O3S. Mole weight: 377.423. | |
| CH5137291 | CH5137291 is a potent androgen receptor (AR) pure antagonist which did not produce the agonist metabolite with AR nuclear translocation-inhibiting activity. It inhibits the growth of castration-resistant prostate cancer cells. It offers a novel therapeutic approach against major types of castration-resistant prostate cancers. Uses: Ch5137291 offers a novel therapeutic approach against major types of castration-resistant prostate cancers. Synonyms: CH-5137291; CH 5137291; CH5137291; UNII-A5ZX7J376H; A5ZX7J376H; CHEMBL1290098. 6-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)pyridine-2-sulfonamide. Grade: >98 %. CAS No. 1043446-39-4. Molecular formula: C18H14F3N5O3S2. Mole weight: 469.46. | |
| CH5138303 | CH5138303 is a novel and potent Hsp90 inhibitor. CH5138303 showed high binding affinity for N-terminal Hsp90α (Kd = 0.52 nM) and strong in vitro cell growth inhibition against human cancer cell lines (HCT116 IC50=0.098 μM, NCI-N87 IC50=0.066 μM) and also displayed high oral bioavailability in mice (F = 44.0%) and potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model (tumor growth inhibition=136%). Synonyms: CH-5138303; CH 5138303. Grade: >98%. CAS No. 959763-06-5. Molecular formula: C19H18ClN5O2S. Mole weight: 415.90. | |
| CH5164840 | CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations. Synonyms: CH5164840; CH-5164840; CH 5164840. Grade: 98%. CAS No. 1052645-73-4. Molecular formula: C19H23N5O2S. Mole weight: 385.49. | |
| CH5424802 analog | CH5424802 analog is a selective inhibitor of ALK capable of blocking the resistant gatekeeper mutant. Synonyms: CH-5424802 analog; 6,6-Dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. CAS No. 1256577-71-5. Molecular formula: C28H30N4O2. Mole weight: 454.56. | |
| CH5424802 Hydrochloride | CH5424802 Hcl (AF 802 Hcl; Alectinib Hcl) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. Synonyms: Alectinib Hydrochloride; AF-802 Hydrochloride; CH-5424802 Hydrochloride; RG-7853 Hydrochloride; RO-5424802 Hydrochloride; AF 802 Hydrochloride; CH 5424802 Hydrochloride; RG 7853 Hydrochloride; RO 5424802 Hydrochloride; AF802 Hydrochloride; CH5424802 Hydrochloride; RG7853 Hydrochloride; RO5424802 Hydrochloride. Grade: >98%. CAS No. 1256589-74-8. Molecular formula: C30H35ClN4O2. Mole weight: 519.08. | |
| CH 55 | CH 55 is an impurity of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: Ch55; Ch-55; Ch 55. 4-[(1E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]benzoic Acid; (E)-4-[3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]-benzoic Acid; Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-. Grade: ≥98% by HPLC. CAS No. 110368-33-7. Molecular formula: C24H28O3. Mole weight: 364.48. | |
| Ch55-O-C3-NH2 | Ch55-O-C3-NH2 is a Ch 55-based ligand which targets RAR. It binds to cIAP1 ligand Bestatin via a linker to form SNIPER. Synonyms: RAR ligand 1. CAS No. 144298-98-6. Molecular formula: C27H35NO4. Mole weight: 437.57. | |
| CH6953755 | YES proto-oncogene 1 has a significant impact on tumor growth. YES1 kinase inhibition by CH6953755 led to antitumor activity against YES1-amplified cancers in vitro and in vivo. Synonyms: CH 6953755. Grade: 98%. CAS No. 2055918-71-1. Molecular formula: C26H22F2N6O4S. Mole weight: 552.55. | |
| CH7057288 | CH7057288 is a selective TRK inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer. Synonyms: N-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonylamino)-11-oxidanylidene-naphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methyl-pyridine-4-carboxamide; HY-107362; CS-0028214; RCH. CAS No. 2095616-82-1. Molecular formula: C32H31N3O5S. Mole weight: 569.67. | |
| CH7233163 | CH7233163 is a non-covalent ATP-competitive inhibitor of EGFR-tyrosine kinase. CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro and in vivo. Synonyms: N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine. Molecular formula: C31H34F3N9O3S. Mole weight: 669.72. | |
| Chaetoglobocin L | Chaetoglobocin L belongs to cytochalasan alkaloid and is a fungal secondary metabolite. Synonyms: (3S,5S,7S,13E,16S,17E,19R,21E)-5-Ethyl-7,19-dihydroxy-3-[(R)-1-(1H-indol-3-yl)ethyl]-16,18-dimethyl-10,11-dinor[13]cytochalasa-6(12),13,17,21-tetrene-1,20,23-trione. CAS No. 83481-23-6. Molecular formula: C34H40N2O5. Mole weight: 556.69. | |
| Chalcone 4 (hydrate) | Chalcone 4 hydrate is an antiparasite agent that inhibits the growth of Babesia and Theileria. Synonyms: (E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate. CAS No. 1202866-96-3. Molecular formula: C16H15ClO4. Mole weight: 306.74. | |
| CHARANTIN(NEW)(P) | Charantin is a potent natural compound derived from bitter melon primarily used in the biomedical industry for the research of diabetes mellitus and related conditions. Synonyms: CHARANTIN(NEW)(P); Monordica Charantia. Grade: 98%. CAS No. 57126-62-2. Molecular formula: A - C35H58O6; B - C35H60O6. Mole weight: 1151.68. | |
| Charantoside | Charantoside. | |
| Charybdotoxin trifluoroacetate salt | Charybdotoxin is a specific inhibitor of the big conductance Ca2+-activated K+ channel which is originally isolated from the scorpion L. quinquestriatus. It blocks large-conductance Ca2+-activated K+ channels (BKCas) in GH3 rat pituitary tumor cells and primary bovine aortic smooth muscle cells (Kds = 2.1 and ~2.1 nM, respectively). Synonyms: ChTX. Grade: ≥95%. Molecular formula: C176H277N57O55S7·xCF3COOH. Mole weight: 4295.90. | |
| Chaulmosulfone | Chaulmosulfone is a cyclopentanetridecananilide derivative with potent antifungal activity. Synonyms: 4',4'''-Sulfonylbis(cyclopentanetridecananilide); Bis(4-(13-cyclophentyltridecanamido)phenyl)sulfone. CAS No. 473-32-5. Molecular formula: C48H76N2O4S. Mole weight: 777.19. | |
| CHEMBL2426474 | CHEMBL2426474, also called as UNC1079, the piperidine analog of UNC1021 that has binding affinity to L3MBTL3 in human G401 cells by Western blot based pulldown assay. Synonyms: CHEMBL2426474UNC1079; UNC-1079; UNC 1079.1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)1418741-86-2BDBM50440571AKOS025405429CS-5532; AK-185224; HY-18373; CS 5532; AK 185224; HY 18373; CS5532; AK185224; HY183731,4-Bis(4-(piperidinyl)piperidinyl)benzamide. CAS No. 1418741-86-2. Molecular formula: C28H42N4O2. Mole weight: 466.67. | |
| CHEMBL333994 | CHEMBL333994 is a potent and orally active antagonist of cholecystokinin A (CCK-A), with an IC50 of 0.67 nM. Synonyms: FK-480; N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N-[(3R)-1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxo[1,4]diazepino[6,7,1-hi]indol-3-yl]-. Grade: ≥95%. CAS No. 167820-10-2. Molecular formula: C26H19FN4O2. Mole weight: 438.45. | |
| CHEMBRDG-BB 7118966 | CHEMBRDG-BB 7118966 is a Bromodomain-containing protein 4 (human) inhibitor. Synonyms: 2(1H)-Quinazolinone, 6-bromo-3,4-dihydro-3-methyl-; 6-Bromo-3,4-dihydro-3-methyl-2(1H)-quinazolinone; 6-Bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one; CHEMBRDG-BB7118966; CHEMBRDG-BB-7118966; 6-bromo-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one. Grade: 95%. CAS No. 328956-24-7. Molecular formula: C9H9BrN2O. Mole weight: 241.08. | |
| Chemerin-9 (149-157) (TFA) | Chemerin-9 (149-157) (TFA) is a potent CMKLR1 (chemokine-like receptor 1) agonist with anti-inflammatory properties. Chemerin-9 (149-157) (TFA) stimulates phosphorylation of Akt and ERK as well as ROS production. Synonyms: H-Tyr-Phe-Pro-Gly-Gln-Phe-Ala-Phe-Ser-OH.TFA. Molecular formula: C56H67F3N10O15. Mole weight: 1177.18. | |
| Chemerin-9, mouse | Chemerin-9, mouse, a ligand for ChemR23, is a potent CMKLR1 agonist. Synonyms: Phe-Leu-Pro-Gly-Gln-Phe-Ala-Phe-Ser. CAS No. 686324-96-9. Molecular formula: C51H68N10O12. Mole weight: 1013.15. | |
| Chemical phosphorylation reagent II | Chemical phosphorylation recompound II is a potent instrument utilized within the realm of biomedical industry, serving as a pivotal component for the intricate phosphorylation reactions. This indispensable recompound orchestrates the modification and activation of select biomolecules encompassing proteins, peptides and nucleotides. Its versatility extends to diverse fields including drug development, signal transduction research and researchs targeting anomalous phosphorylation processes underlying numerous pathologies. Synonyms: 2-[(4,4'-Dimethoxytrityloxy)methyl]-2-[[(diisopropylamino)(2-cyanoethoxy)phosphinooxy]methyl]malonic acid diethyl ester. Grade: >95% by HPLC. Molecular formula: C39H51N2O9P. Mole weight: 722.82. | |
| ChemR23-IN-1 | ChemR23-IN-1 is a ChemR23 inhibitor that acts on human and mouse ChemR23 with IC50 values of 38 nM and 100 nM, respectively. It blocks Chemerin-triggered CAL-1 chemotaxis in vitro. CAS No. 2378640-10-7. Molecular formula: C28H29N7O2. Mole weight: 495.58. | |
| Chenodeoxycholic acid 24-acyl-b-D-glucuronide | Chenodeoxycholic acid 24-acyl-β-D-glucuronide is an indispensable constituent within the biomedical domain predominantly employed for the therapeutic research of hepatic ailments including cholestasand biliary cirrhosis. This compound exerts formidable hepatoprotective attributes and ensures the homeostasis of bile acid metabolism. Synonyms: 1-[(3a,5b,7a)-3,7-Dihydroxycholan-24-oate] b-D-glucopyranuronic acid. CAS No. 208038-27-1. Molecular formula: C30H48O10. Mole weight: 568.70. | |
| Chevalone B | Chevalone B is a meroterpenoid originally isolated from the fungus E. chevalieri. It is cytotoxic to KB and NCI-H187 cells (IC50s = 2.9 and 9.8 μg/ml, respectively). Synonyms: Chevalone B; 1318025-75-0; [(1R,2S,11S,14R,15R,18S,20R)-1,7,11,15,19,19-hexamethyl-5-oxo-6,10-dioxapentacyclo[12.8.0.02,11.04,9.015,20]docosa-4(9),7-dien-18-yl] acetate; (2S,4aR,4bR,6aS,12aS,12bR,14aR)-2-(acetyloxy)-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1,1,4a,6a,9,12b-hexamethyl-1H,11H-phenanthro[2,1-b]pyrano[3,4-e]pyran-11-one; AKOS040755472. Grade: >95% by HPLC. CAS No. 1318025-75-0. Molecular formula: C28H40O5. Mole weight: 456.61. | |
| Chevalone E | Chevalone E is a meroterpene produced by the strain of A. similanensis. Synonyms: Deacetylchevalone C. Grade: >95% by HPLC. CAS No. 1315451-94-5. Molecular formula: C26H38O4. Mole weight: 414.58. | |
| c-hexaAMP | c-hexaAMP is a novel bacterial second messengers involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements in many prokaryotes. Grade: ≥ 95% by HPLC. CAS No. 232933-63-0. Molecular formula: C60H72N30O36P6 (free acid). Mole weight: 1975.3 (free acid). | |
| CHF 1255 | CHF 1255, a tetrahydronaphthalen derivative, has been found to be probably effective against heart failure. Synonyms: CHF 1255; CHF1255; CHF-1255. SCHEMBL7435679; 5,6-Dimethoxy-2-(3'-(4-hydroxyphenyl)-3'-hydroxy-2'-propyl)aminotetralin; 146728-52-1; 4-[1-Hydroxy-2-[[(5,6-dimethoxy-1,2,3,4-tetrahydronaphthalen)-2-yl]amino]propyl]phenol. Grade: 98%. CAS No. 146728-52-1. Molecular formula: C21H27NO4. Mole weight: 357.44. | |
| CHF-2993 | CHF-2993. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; CHF-2993; CHF2993; CHF 2993; UNII-5NY5Q1OUZ3; 5NY5Q1OUZ3. Grade: >98%. CAS No. 202914-21-4. Molecular formula: C12H16N2O2. Mole weight: 220.27. | |
| CHF-4227 | CHF-4227 is a selective estrogen receptor modulator, binds with high affinity to the human estrogen receptor-alpha and -beta (dissociation constant K(I) = 0.017 and 0.099 nM, respectively). Uses: Estrogen receptor modulator. Synonyms: CHF4227; CHF 4227; CHF-4227; 3-(4-methoxyphenyl)-4-(4-(2-(piperidin-1-yl)ethoxy)benzyl)-2H-chromen-7-ol. Grade: ≥98%. CAS No. 444643-64-5. Molecular formula: C30H33NO4. Mole weight: 471.59. | |
| CHF-5022 | CHF-5022 is a non-steroidal anti-inflammatory agent. It can selectively inhibit the production of beta-amyloid(1-42). Uses: Anti-inflammatory agent. Synonyms: CHF-5022; CHF 5022; CHF5022; UNII-JO8EVV007Q; CHEMBL196246; CHF-5022; JO8EVV007Q; SCHEMBL1373506; BDBM50172463. UNII-JO8EVV007Q; CHEMBL196246; CHF-5022; JO8EVV007Q; SCHEMBL1373506; BDBM50172463; Cyclopropanecarboxylic acid, 1-(2-fluoro-4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)-. Grade: 98%. CAS No. 749269-77-0. Molecular formula: C17H12F4O2. Mole weight: 324.27. | |
| CHF 5074 | CHF 5074 is a novel γ-secretase modulator. It reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM respectively. It protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. Uses: Chf5074 induces microglia alternative activation in plaque-free tg2576 mice and primary glial cultures exposed to beta-amyloid. it restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque tg2576 mice. it is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of alzheimer's disease. it significantly reduces the apoptosis in hippocampal neurons exposed to ogd, as revealed by cleaved-caspase-3 immunoreactivity and tunel staining. Synonyms: CHF-5074; Itanapraced; 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid. Grade: >98%. CAS No. 749269-83-8. Molecular formula: C16H11Cl2FO2. Mole weight: 325.16. | |
| CHF-6001 | This active molecular is a Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor originated by Chiesi Farmaceutici with IC50 value of 0.026 ± 0.006 nM. CHF6001 inhibited PDE4 isoforms A to D with equal potency, showed an elevated ratio of high-affinity rolipram binding site versus low-affinity rolipram binding site and displayed >20,000-fold selectivity versus PDE4 compared with a panel of PDEs. In May 2016, Chiesi completed a phase I trial in Chronic Obstructive Pulmonary Disease (In volunteers) in United Kingdom (Inhalation). In Oct 2016, Phase-II clinical trials in Chronic obstructive pulmonary disease (Adjunctive treatment) in Hungary (Inhalation) was on-going. Uses: Allergic asthma; chronic obstructive pulmonary disease. Synonyms: CHF-6001; CHF 6001; CHF6001. UNII-0984EU6E2F; 0984EU6E2F; CHEMBL3113974; SCHEMBL12096092; CHF6001; VCFBPAOSTLMYIV-SANMLTNESA-N; [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 3-(cyclopropylmethoxy)-4-(methanesulfonamido)benzoate. Grade: 98%. CAS No. 1239278-59-1. Molecular formula: C30H30Cl2F2N2O8S. Mole weight: 687.53. | |
| CHF-6162 | CHF-6162 is an agonist of glucocorticoid receptor (GR) (IC50 = 0.24nM), which shows greater potency than fluticasone and budesonide in a radioligand binding assay. Uses: The potential teatment of airway inflammation. Synonyms: CHF-6162; CHF 6162; CHF6162. | |
| CHF-6366 | CHF-6366 is a dual-acting antagonist of muscarinic acetylcholine receptor M3 and beta-2 adrenergic receptor (MABA) being developed as inhalable bronchodilator. Stusies in vivo and in vitro showed that CHF-6366 is a promising drug for the treatment of chronic obstructive pulmonary disease with long-acting, low toxic and potent activity. Uses: The potential treatment of chronic obstructive pulmonary disease. Synonyms: CHF 6366; CHF6366. CAS No. 1615208-41-7. Molecular formula: C42H48N6O8. Mole weight: 764.87. | |
| Chiauranib | Chiauranib, an orally active multi-target inhibitor against tumor angiogenesis, potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. It has strongly anticancer effects. Uses: Antineoplastic agents. Synonyms: CS2164; N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide; N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide; 1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-. Grade: ≥95%. CAS No. 1256349-48-0. Molecular formula: C27H21N3O3. Mole weight: 435.47. | |
| Chicago Sky Blue 6B | Chicago Sky Blue 6B is a counterstain for background autofluorescence and an allosteric MIF inhibitor. Uses: Coloring agents. Synonyms: Direct Blue 1; Pontamine sky blue; Chicago Sky Blue. CAS No. 2610-5-1. Molecular formula: C34H24N6Na4O16S4. Mole weight: 992.80. | |
| Chidamide | Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418. | |
| Chidamide-D4 | An isotope labelled of Chidamide. Chidamide is an histone deacetylase inhibitor and is being researched as a treatment for pancreatic cancer. Grade: 95% by HPLC; 98% atom D. Molecular formula: C22H15D4FN4O2. Mole weight: 394.44. | |
| Chiglitazar | Chiglitazar is a potent and selective PPAR agonist potentially for the treatment of type 2 diabetes. Synonyms: Carfloglitazar; CS-038; CS 038; CS038. CAS No. 743438-45-1. Molecular formula: C36H29FN2O4. Mole weight: 572.62. | |
| Chi Lob 7/4 | An IgG1 chimeric monoclonal antibody agonist of CD40 with potential immunostimulatory and antineoplastic activities. | |
| CHIR-090 | CHIR-090 is a very potent and tight-binding inhibitor of LpxC, which is a zinc-dependent amidase and present in almost all Gram-negative bacteria, and is a promising target for the development of novel antibiotic substances against multigrug-resistant Gram-negative bacteria. Its Ki value is 4.0 nM. It displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. It has a different selectivity with the reported LpxC inhibitor L-161. It has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli by inhibiting LpxC orthologs at low nM concentrations. It is an excellent lead for the further development of new antibiotics targeting the lipid A pathway. Uses: Chir-090 displays two-step time-dependent inhibition and kills a wide range of gram-negative pathogens as effectively as ciprofloxacin or tobramycin. it has excellent antibiotic activity against pseudomonas aeruginosa and escherichia coli by inhibiting lpxc orthologs at low nm concentrations. Synonyms: CHIR-090; CHIR 090; CHIR090. N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide. Grade: 98%. CAS No. 728865-23-4. Molecular formula: C24H27N3O5. Mole weight: 437.49. | |
| CHIR-124 | CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons. Synonyms: CHIR-124; CHIR 124; CHIR124. Grade: 0.98. CAS No. 405168-58-3. Molecular formula: C23H22ClN5O. Mole weight: 419.913. | |
| CHIR 2279 | CHIR 2279, an isoquinolin derivative, was once studied against hypertension as an α1 adrenergic receptor antagonist. Synonyms: Chir 2279; Chir2279; Chir 2279; (N-(2-(4-Hydroxyphenyl)ethyl)glycyl)-(N-(4-biphenylyl)glycyl)-N-(2-phenylethyl)glycinamide. Grade: 98%. CAS No. 158198-45-9. Molecular formula: C34H36N4O4. Mole weight: 564.674. | |
| CHIR-29498 | CHIR-29498 is a peptoid antibacterial agent. Synonyms: 2-[[(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methylamino]-N-(2-aminoethyl)-N-[2-[(2-amino-2-oxoethyl)-(1,2,3,4-tetrahydronaphthalen-1-yl)amino]-2-oxoethyl]acetamide ; CHIR-29498; CHIR 29498; CHIR29498; UNII-43I7U24XMF. Grade: >98%. CAS No. 236102-25-3. Molecular formula: C38H55N5O3. Mole weight: 629.88. | |
| CHIR 4531 | CHIR 4531, an oligopeptides compound, has been found to be an opioid mu receptor agonist and was once studied in pain therapy. Synonyms: Chir 4531; Chir4531; Chir-4531; AC1L322L; DTXSID90166381; (N-(2,2-Diphenylethyl)glycyl)-(N-(3,4-(methylenedioxy)benzyl)glycyl)-N-(2-(4-hydroxyphenyl)ethyl)glycinamide; AM017371. Grade: 98%. CAS No. 158198-48-2. Molecular formula: C36H38N4O6. Mole weight: 622.72. | |
| CHIR-98014 | CHIR-98014 is a GSK3 inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β respectively. It can activate Wnt/β-catenin pathway in mouse embryonic stem cells (mESCs). Synonyms: CHIR98014; 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine. Grade: >98%. CAS No. 252935-94-7. Molecular formula: C20H17Cl2N9O2. Mole weight: 486.31. | |
| CHIR-98023 | CHIR-98023 is a glycogen synthase kinase 3 inhibitor developed for the treatment of Type 2 diabetes mellitus. Synonyms: N'-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]-N-(5-nitropyridin-2-yl)ethane-1,2-diamine; CHIR-98023; CHIR98023; CHIR 98023; CT-98023; UNII-CMQ1L0E91Y; CHIR-837. Grade: >98%. CAS No. 252916-76-0. Molecular formula: C20H16Cl2N8O2. Mole weight: 471.3. | |
| CHIR-98024 | CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Synonyms: CHIR98014; CHIR-98014; CHIR 98014; CT 98024; CT-98024; CT98024. Grade: 98%. CAS No. 556813-39-9. Molecular formula: C20H17Cl2N9O2. Mole weight: 486.31. | |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grade: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. | |
| CHIR 99021 dihydrochloride | CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor. Synonyms: CHIR-99021 dihydrochloride; CHIR99021 dihydrochloride; CT-99021 dihydrochloride; CT 99021 dihydrochloride; CT99021 dihydrochloride; GSK-3 Inhibitor XVI dihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile dihydrochloride. Grade: 99%. CAS No. 2109414-84-6. Molecular formula: C22H18Cl2N8.2HCl. Mole weight: 538.26. | |
| CHIR99021 HCl | CHIR99021, also known as CT99021, is a GSK-3α/β inhibitor (IC50= 10 nM/6.7 nM) with antiproliferative activity in vitro and in vivo. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Synonyms: 6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile hydrochloride; CHIR99021 HCl; CHIR99021 hydrochloride; CHIR99021; CHIR-99021; CHIR 99021; CT99021; CT-99021; CT 99021. CAS No. 1797989-42-4. Molecular formula: C22H19Cl3N8. Mole weight: 501.8. | |
| CHIR 99021 trihydrochloride | CHIR 99021 is a highly selective GSK-3 inhibitor. CHIR 99021 is used in the treatment of parkinsonism. Uses: The treatment of parkinsonism. Synonyms: CHIR-99021 trihydrochloride; CHIR 99021 trihydrochloride; CHIR99021 trihydrochloride; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride. Grade: ≥98% by HPLC. CAS No. 1782235-14-6. Molecular formula: C22H18Cl2N8.3HCl. Mole weight: 574.72. | |
| Chitinase-IN-1 | Chitinase-IN-1 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 75%/67% for chitinase/N- acetyl-hexosaminidase respectively. Synonyms: Chitinase-IN-1. Grade: >98%. CAS No. 1579991-61-9. Molecular formula: C18H16N4O2S. Mole weight: 352.41. | |
| Chitinase-IN-2 | Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 98%/92% for chitinase/N- acetyl-hexosaminidase respectively. Synonyms: Chitinase-IN-2. Grade: >98%. CAS No. 1579991-63-1. Molecular formula: C20H21N5O2S. Mole weight: 395.48. | |
| Chitin azure | Chitin azure has been used as a substrate to determine chitinase activity. | |
| Chitobiose | Chitobiose is a highly significant compound extensively employed in the compound sector, serving as a fundamental component facilitating chitosan research, an environmentally friendly polymer derived from crustacean exoskeletons. With its pivotal involvement, Chitobiose 2HCl plays a fundamental role in the progression of targeted therapeutic drug delivery systems. Synonyms: Chitosan dimer; 4-O-(b-D-Glucosamine)-D-glucosamine; 2-Amino-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-D-glucose; 4-O-(2-Amino-2-deoxy-β-D-glucosyl)-D-glucosamine. CAS No. 577-76-4. Molecular formula: C12H24N2O9. Mole weight: 340.33. | |
| Chitobiose dihydrochloride | Chitobiose Hydrochloride is an exceptional biomedical compound, exhibiting profound versatility in research of numerous ailments encompassing cancer and diabetes. Its indispensable role as a pivotal intermediate in chitin research and development imparts promising prospects to the realms of pharmaceutical conveyance platforms and tissue engineering. Synonyms: Chitobiose 2HCl; D-Glucose, 2-amino-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-, hydrochloride (1:2); 2-Amino-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-D-glucose hydrochloride (1:2); D-Glucose, 2-amino-4-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-2-deoxy-, dihydrochloride; Chitobiose Hydrochloride; 4-O-(2-Amino-2-deoxy-β-D-glucosyl)-D-glucosamine dihydrochloride. Grade: ≥97% by HPLC. CAS No. 115350-24-8. Molecular formula: C12H24N2O9.2HCl. Mole weight: 413.25. | |
| Chitobiose GEL | Chitobiose GEL. | |
| Chitobiose octaacetate | Chitobiose octaacetate, a carbohydrate derivative, is a promising candidate for the treatment of osteoarthritis. Studies demonstrate that it inhibits cartilage-degrading enzymes, the primary culprits of joint degradation in the disease. Furthermore, it attenuates inflammation and pain associated with osteoarthritis. Experts are currently examining its potential as a therapeutic agent, while the manifold intricacies of its pharmacological workings prompt ongoing investigation. Synonyms: 2-acetamido-4-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-alpha-D-glucose 1,3,3',4',6,6'-hexaacetate; 1-O,3-O,6-O-Triacetyl-4-O-[3-O,4-O,6-O-triacetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-2-(acetylamino)-2-deoxy-α-D-glucopyranose; N,N'-Diacetylchitobiose hexaacetate; α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-4-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-, 1,3,6-triacetate; octaacetylchitobiose. Grade: ≥95%. CAS No. 7284-18-6. Molecular formula: C28H40N2O17. Mole weight: 676.62. | |
| Chitodecaose Hydrochloride | Chitodecaose Hydrochloride is an innovative and groundbreaking pharmaceutical compound derived from the polymer Chitodecaose, exhibiting a touch of uniqueness stemming from chitosan. Its multifaceted nature encompasses remarkable antiviral and antibacterial attributes that have garnered substantial attention. Synonyms: Chitodecaose 10HCl; D-Glucose, O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-, hydrochloride (1:10). Grade: ≥93% by HPLC. Molecular formula: C60H112N10O41.10HCl. Mole weight: 1994.17. | |
| Chitoheptaose | Chitoheptaose, a versatile compound extensively employed in the biomedicine sector, exhibits tremendous promise for addressing diverse ailments, encompassing cancer and inflammatory disorders. Functioning as an immunomodulator, this product effectively regulates immune responses and fortifies the body's defense mechanisms. Synonyms: O-2-Amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-D-glucose. CAS No. 68232-35-9. Molecular formula: C42H79N7O29. Mole weight: 1146.11. | |
| Chitoheptaose Hydrochloride | Chitoheptaose Hydrochloride is a remarkable compound, unveiling unrivaled potential in personalized researchs by selectively modulating distinct molecular pathways. Its multifaceted utility spans across research of malignant neoplasms, inflammatory conditions and bacterial afflictions. Synonyms: Chitoheptaose 7HCl; Chitoheptaose heptahydrochloride; D-Glucose, O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-, heptahydrochloride; O-2-Amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-D-glucose heptahydrochloride. Grade: ≥96% by HPLC. CAS No. 127171-89-5. Molecular formula: C42H79N7O29.7HCl. Mole weight: 1401.33. | |
| Chitohexaose | Chitohexaose, a chitosan oligosaccharide with anti-inflammatory effect, binds to the active site of TLR4 and inhibits LPS-induced inflammation. Synonyms: D-Glucose, O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-; 2-Amino-2-deoxy-β-D-glucopyranosyl-(1->4)-2-amino-2-deoxy-β-D-glucopyranosyl-(1->4)-2-amino-2-deoxy-β-D-glucopyranosyl-(1->4)-2-amino-2-deoxy-β-D-glucopyranosyl-(1->4)-2-amino-2-deoxy-β-D-glucopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose. Grade: ≥95%. CAS No. 41708-95-6. Molecular formula: C36H68N6O25. Mole weight: 984.95. | |
| Chitohexaose hexahydrochloride | Chitohexaose hexahydrochloride, a chitosan oligosaccharide with anti-inflammatory effect, binds to the active site of TLR4 and inhibits LPS-induced inflammation. Synonyms: D-Glucose, O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-, hydrochloride (1:6); O-2-Amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-D-glucose hydrochloride (1:6). Grade: ≥95%. CAS No. 127171-88-4. Molecular formula: C36H74Cl6N6O25. Mole weight: 1203.72. | |
| Chitohexaose Hydrochloride | Chitohexaose Hydrochloride is an extraordinary biomedical compound, an inherently-occurring oligosaccharide obtained from chitin. Profoundly endowed with anti-inflammatory and immunostimulating prowess, Chitohexaose Hydrochloride unveiling immense promise in the research of allergies, asthma and the augmentation of wound healing. Synonyms: Chitohexaose HCl; D-Glucose, O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-, hydrochloride (1:x); O-2-Amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-O-2-amino-2-deoxy-β-D-glucopyranosyl-(1→4)-2-amino-2-deoxy-D-glucose hydrochloride. Grade: ≥96% by HPLC. CAS No. 133213-35-1. Molecular formula: C36H68N6O25.xHCl. Mole weight: 984.95 (free base). | |
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