BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Celecoxib EP Impurity A | A meta positional isomer of Celecoxib with selective inhibitory activity against human cyclooxygenase-2. Synonyms: Celecoxib USP Related Compound A; Celecoxib 3-Methyl Analog; 4-Desmethyl-3-methyl Celecoxib; 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide. Grade: > 95%. CAS No. 170570-01-1. Molecular formula: C17H14F3N3O2S. Mole weight: 381.38. |  |
| Celecoxib EP Impurity B | An isomeric impurity of Celecoxib with selective inhibitory activity against human cyclooxygenase-2. Synonyms: Celecoxib USP Related Compound B; N-De(4-sulfonamidophenyl)-N'-(4-sulfonamidophenyl) Celecoxib. Grade: > 95%. CAS No. 331943-04-5. Molecular formula: C17H14F3N3O2S. Mole weight: 381.38. | |
| Celecoxib Ethyl Ester | An impurity of Celecoxib, which is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Synonyms: ethyl 4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) benzenesulfonate. CAS No. 2247197-67-5. Molecular formula: C19H17F3N2O3S. Mole weight: 410.41. | |
| Celecoxib Impurity 2 | An impurity of celecoxib, a cyclooxygenase 2 inhibitor. Synonyms: 1H-Pyrazole, 5-(4-methylphenyl)?-3-(trifluoromethyl)?-; 5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazole; 5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazole; 5-(4-Methylphenyl)-3-trifluoromethyl-1H-pyrazole; Celecoxib Impurity H. Grade: > 95%. CAS No. 948293-46-7. Molecular formula: C11H9F3N2. Mole weight: 226.2. | |
| Celecoxib Impurity 4 | An impurity of Celecoxib, which is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Synonyms: 4-(5-hydroxy-3-(p-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide; Benzenesulfonamide, 4-(5-hydroxy-3-(p-tolyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl). Grade: 95%. CAS No. 1803258-57-2. Molecular formula: C17H16F3N3O3S. Mole weight: 399.39. | |
| Celecoxib Impurity 5 | A metabolite of Celecoxib. Synonyms: 4-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide. Grade: > 95%. CAS No. 170571-00-3. Molecular formula: C17H14F3N3O3S. Mole weight: 397.38. | |
| Celecoxib Impurity HCl (4-Hydrazinobenzene-1-sulfonamide HCl) | 4-Sulfonamide-Phenylhydrazine HCl is an intermediate to produce Celebrex. Synonyms: 4-Hydrazino-benzenesulfonamide Hydrochloride; [4-(Aminosulfonyl)phenyl]hydrazine Hydrochloride. Grade: > 95%. CAS No. 17852-52-7. Molecular formula: C6H9N3O2S.HCl. Mole weight: 223.68. | |
| Celecoxib impurity (N-Acetyl-4-(2-Aminoethyl)-Benzenesulfonamide) | N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-acetamide is used in the synthesis of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups that can be used as potential hypoglycemic agents. Synonyms: N-p-Sulfamoylphenethyl-acetamide; 4-(2-Acetylaminoethyl)benzenesulfonamide; N-(p-Sulfamoylphenethyl)acetamide. Grade: > 95%. CAS No. 41472-49-5. Molecular formula: C10H14N2O3S. Mole weight: 242.3. | |
| Celecoxib Methyl Ester | An impurity of Celecoxib, which is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Synonyms: methyl 4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) benzenesulfonate; Celecoxib Impurity 23; Benzenesulfonic acid, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-, methyl ester. CAS No. 2247197-66-4. Molecular formula: C18H15F3N2O3S. Mole weight: 396.38. | |
| Celgosivir hydrochloride | Celgosivir hydrochloride is the hydrochloride salt of Celgosivir which is anα-glucosidase inhibitor and inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in vitro assay. Synonyms: [(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate; hydrochloride; Celgosivir HCl; UNII-70U2NQU0FP; Celgosivir (hydrochloride); MDL 28574A. Grade: ≥98% (HPLC). CAS No. 141117-12-6. Molecular formula: C12H22ClNO5. Mole weight: 295.76. | |
| Celikalim | Celikalim is s ATP-sensitive potassium channel agonist originated by Wyeth. It increases K+ outward flux in dog and human airway smooth muscle. But clinical trials for Hypertension, Ischaemic heart disorders and Thrombosis was discontinued. Uses: Hypertension; ischaemic heart disorders; thrombosis. Synonyms: Way-120,491; Way120491; Way-120491; Way 120491; Celikalim; 2-[(3S,4R)-3-hydroxy-2,2-dimethyl-6-(trifluoromethoxy)-3,4-dihydrochromen-4-yl]-3H-isoindol-1-one. Grade: 98%. CAS No. 124916-54-7. Molecular formula: C20H18F3NO4. Mole weight: 393.36. | |
| Celiprolol hydrochloride | Celiprolol hydrochloride is a cardioselective β1-adrenergic blocker with potential antianginal and antihypertensive properties. Synonyms: Celiprolol HCl; 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea hydrochloride. Grade: 98%. CAS No. 57470-78-7. Molecular formula: C20H33N3O4.HCl. Mole weight: 415.95. | |
| Celiprolol Impurity B | N,N'-Bis[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea is an impurity of Celiprolol which is a cardioselective β1-adrenergic blocker. Synonyms: N 113; Celiprolol Aniline Carboxy Dimer. Grade: > 95%. CAS No. 125579-40-0. Molecular formula: C31H46N4O7. Mole weight: 586.73. | |
| Celiptium | Celiptium, also known as elliptinium acetate, a topoisomerase II inhibitor, is the acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. Uses: Antineoplastic agents. Synonyms: Ellipticine acetate; Elliptinium acetate; Celiptium; 9-HME; HME; NMHE; 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium acetate. Grade: 98%. CAS No. 58337-35-2. Molecular formula: C20H20N2O3. Mole weight: 336.39. | |
| Cellobiitol | Cellobiitol, an extraordinary biomedical marvel, revolutionizes the landscape of disease treatment and management. It embodies a pivotal role in precisely navigating specific drugs and therapies towards their target destinations, augmenting delivery efficacy and optimizing therapeutic outcomes. Synonyms: 4-O-(b-D-Glucopyranosyl)-D-glucitol; 4-O-β-D-Glucopyranosyl-D-glucitol; Glucitol, 4-O-β-D-glucopyranosyl-, D-; Cellobiit. CAS No. 535-94-4. Molecular formula: C12H24O11. Mole weight: 344.31. | |
| Cellobionic acid ammonium salt | Cellobionic acid ammonium salt is a potent biomedical compound used in the research of various metabolic disorders. With its unique chemical properties, it assists in the compoundion of specific enzymes studying enzymatic deficiencies caused by genetic disorders. Synonyms: 4-O-b-D-Glucopyranosyl-D-gluconic acid. CAS No. 534-41-8. Molecular formula: C12H22O12. Mole weight: 358.30. | |
| Cellobiose-6'-phosphate | Cellobiose-6'-phosphate, an imperative intermediary in the intricate process of carbohydrate metabolism, manifests as a formidable substrate for an array of enzymes engaged in the biosynthesis of cellulose, a fundamental constituent of plant cell walls. Its remarkable aptitude to elicit cellulose synthesis endows Cellobiose-6'-phosphate with a momentous function in the advancement of anti-fungal medicaments that diligently target cellulose synthesis pathways. Synonyms: Cellobiose 6-phosphate; 6-phospho-beta-D-glucosyl-(1->4)-beta-D-glucose; 4-O-(6-O-phosphono-beta-D-glucopyranosyl)-beta-D-glucopyranose; 6-O-phosphono-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranose; beta-D-cellobiose 6'-phosphate. Molecular formula: C12H23O14P. Mole weight: 422.28. | |
| Cellobiosyl fluoride | Cellobiosyl fluoride is a profound chemical compound embraced in the realm of biomedical science, finding its purpose in scrutinizing and impeding enzymes implicated in the intricate disintegration of cellulose. By virtue of its presence, it bestows upon researchers an invaluable instrument to fathom the intricate machinations underpinning cellulose degradation within microorganisms. Synonyms: 4-O-b-D-Glucopyranosyl-a-D-glucopyranosyl fluoride. CAS No. 103531-01-7. Molecular formula: C11H19FO11. Mole weight: 346.26. | |
| Cellobiulose | Cellobiulose. Synonyms: 4-O-β-D-Glucopyranosyl-D-fructose. CAS No. 26391-66-2. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| Cellobiuronic acid | Cellobiuronic acid is a remarkably multifaceted biocompound, standing as an instrumental medicinal compound harnessed to study afflictions of the urinary tract and gastrointestinal disturbances. Synonyms: 4-O-b-D-Glucopyranuronosyl-D-glucose. CAS No. 5551-59-7. Molecular formula: C12H20O12. Mole weight: 356.28. | |
| Cellooctaose | Cellooctaose is a renowned biomedical compound, finding wide application in the research of diverse ailments. It exhibits remarkable potential as a compound by efficiently regulating immune responses. Extensive studies have elucidated its anti-inflammatory attributes and substantiated its usefulness in formulating drugs targeting immune-related maladies including autoimmune disorders and allergies. The utilization of Cellooctaose holds immense prospects for enhancing patient outcomes and bolstering research efficacy. Synonyms: Glc(b1-4)Glc(b1-4)Glc(b1-4)Glc(b1-4)Glc(b1-4)Glc(b1-4)Glc(b1-4)b-Glc; beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranosyl-(1->4)-beta-D-gluco-hexopyranose; beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranose. Molecular formula: C48H82O41. Mole weight: 1315.14. | |
| Cellotrionic acid | Cellotrionic acid is a neuroprotective compound used for research of the perils of neurodegenerative afflictions. Synonyms: O-b-D-Glucopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->4)-D-Gluconic acid. CAS No. 50819-69-7. Molecular formula: C18H32O17. Mole weight: 520.44. | |
| Cellouronic acid sodium salt | Cellouronic acid sodium salt. | |
| Celluchrome | Celluchrome is a profound compound for studying cellulose-related ailments with incisive mechanism zealously singles out and disassembles intricate cellulose formation. Synonyms: Remazol brilliant blue carboxymethyl cellulose. | |
| Cellulase inhibitor PG 7145185 | Cellulase inhibitor PG 7145185, a fundamental discovery, revolutionizes the biomedical landscape. Meticulously tailored, this inhibitor successfully targets cellulase enzymes intricately engaged in the degradation of cellulose. Its ingenious mechanism impedes the disintegration of cellulose, a paramount facet indispensable for combatting multifarious maladies like cellulose-based tumors. Synonyms: 1-Trifluoromethyl cellobiose. Grade: 95%. Molecular formula: C13H21O11F3. Mole weight: 410.29. | |
| Cellulose acetate | Cellulose acetate was used in the fabrication of gold microelectrode for electrochemical monochloramine measurement. Cellulose acetate based membranes are used in the separations in aqueous systems and in reverse osmosis process. It has been reported to be used to desalinate seawater.Cellulose acetate was used for biosensor encapsulation. It was used in the preparation of cellulose acetate nanofibre felt structure, cellulose acetate fibers. Synonyms: Acetic acid, cellulose ester; Acetyl cellulose; Acetylcellulose. CAS No. 9004-35-7. | |
| Cellulose acetate butyrate | Cellulose acetate butyrate (CAB) is a cellulose ester with good clarity, toughness, and chemical resistance. It is widely used in films, coatings, plastic molding, adhesives, and printing inks. Synonyms: Cellulose, acetate butanoate; Cellulose acetate butyrate polymer; Cellulose acetobutyrate; Acetobutyrate cellulose; Acetylbutyrylcellulose; Cabloid CAB; Cabufocon; Cellidor BM; Cellulose butyrate acetate; Celluose acetate butyrate; Celullose acetate butyrate; CRF 903; EAB; EAB (cellulose derivative); Eastmancab; Ensure 100; Tenite butyrate; Tenite Butyrate 525; Tenite CAB; Tenite CAB 460A; Tenite II; Tenth Second; Triafol BN; Umanax F; Uvex. CAS No. 9004-36-8. | |
| Cellulose acetate hydrogen phthalate | Cellulose acetate phthalate(CAP) is used as an enteric film coating material or as a matrix binder for tablets and capsules. Such coatings resist prolonged contact with the strongly acidic gastric fluid, but dissolve in the mildly acidic or neutral intestinal environment. Synonyms: Cellulose, acetate, 1,2-benzenedicarboxylate; Acetyl phthalyl cellulose; Aquacoat cPD; CAP; cellacephate; cellulose acetate benzene-1,2-dicarboxylate; cellulose acetate hydrogen 1,2-benzenedicarboxylate; cellulose acetate hydrogen phthalate; cellulose acetate monophthalate; cellulose acetophthalate; cellulose acetylphthalate; cellulosi acetas phthalas. CAS No. 9004-38-0. | |
| Cellulose acetate trimellitate | Cellulose Acetate Trimellitate is a biocompatible polymer used in the biomedical industry for its applications in drug delivery systems. It is commonly employed as a carrier material to formulate oral sustained-release dosage forms, especially for drugs sensitive to pH and enzymes in the gastrointestinal tract. This compound enhances compound stability and facilitates controlled release, making it suitable for studying various diseases effectively. Synonyms: Cellulose, acetate 1,2,4-benzenetricarboxylate; Cellulose acetotrimellitate; Cellullose acetate trimellitate; Cellulose acetotrimellitate. Grade: 95%. CAS No. 52907-01-4. | |
| Cellulose, carboxymethyl ether, ammonium salt | Cellulose, carboxymethyl ether is ammonium salt is a biocompatible and water-soluble polymer, proving indispensable as a drug carrier for targeted drug delivery systems, specifically studying the exigencies associated with cancer therapy and inflammatory ailments. Its utilization in pharmaceutical formulations derives paramount importance from its pronounced compound encapsulation and controlled release attributes. Synonyms: Ammonium carboxymethyl cellulose; Carboxymethylcellulose ammonium salt. Grade: 95%. CAS No. 9086-60-6. | |
| Cellulose diacetate | It is widely used in the sustained-release applications and taste masking in pharmaceutical formulatiosn. Synonyms: Cellulose, diacetate; Acetate Flake L 70; Biocell; Biocellat; CDA; CDA 5770; Diacetyl cellulose; LT 40 (cellulose derivative); LT 50; MGH; MI Flake; Mycel CDA 5770; VRR 124; XK 10. Grade: 98%. CAS No. 9035-69-2. | |
| Cellulose sulfate sodium salt | Cellulose sulfate sodium salt is a critically significant compound within the realm of biomedical sciences, standing as an avant-garde solution catering to the research of paramount viral afflictions such as HIV/AIDS and various sexually transmitted diseases. Synonyms: Sodium cellulose sulfate; Kelco SCS; Cellulose, hydrogen sulfate, sodium salt; Cellulose sodium sulfate; SCS; Sodium cellulosesulfonate; SS Cellulose; Ushercell. CAS No. 9005-22-5. | |
| Cellulose triacetate | It is widely used in the sustained-release applications and taste masking in pharmaceutical formulatiosn. Synonyms: Cellulose Triacetate Polymer; 2,3,6-Tri-O-acetyl Cellulose; Acetate Flake L 30. CAS No. 9012-9-3. | |
| CEM114 | CEM114 is a potent chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through the CRISPR-Cas9 systems. Synonyms: AKOS040757520; 2279062-54-1. CAS No. 2279062-54-1. Molecular formula: C84H122FN9O19S. Mole weight: 1612.98. | |
| Cemadotin | Cemadotin is a synthetic analogue of Dolastatin 15 with potent antiproliferative and preclinical antitumor activity. It is also a promising cancer chemotherapeutic agent. Synonyms: LU 103793; LU-103793; LU103793; NSC D-669356; N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinebenzylamide. CAS No. 159776-69-9. Molecular formula: C35H56N6O5. Mole weight: 640.87. | |
| Cemiplimab | Cemiplimab is a PD-1 monoclonal antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab has been approved for the treatment of metastatic cutaneous squamous cell carcinoma (CSCC). Synonyms: Libtayo. CAS No. 1801342-60-8. | |
| CeMMEC1 | CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (Kd = 1.8 μM; IC50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. CeMMEC1 can also inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. Synonyms: CeMMEC1; 440662-09-9; N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide; N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxoisoquinoline-4-carboxamide; Oprea1_520920; SCHEMBL20942542; BCP19839; EX-A1815; EiM08-22966; AKOS005754739; AC-35499; MS-25094; HY-111445; CS-0040872; Z1863671528; N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2-METHYL-1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXAMIDE. Grade: ≥98%. CAS No. 440662-09-9. Molecular formula: C19H16N2O4. Mole weight: 336.3. | |
| CeMMEC13 | CeMMEC13 is an isoquinolinone and a potent inhibitor of TAF1 bromodomain with IC50 of 2.1 μM. It acts on the bromodomain of TAF1 but does not bind to bromodomains of BRD4, BRD9, or CREBBP. CeMMEC13 synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. Synonyms: CeMMEC13; 1790895-25-8; 1-Methyl-2-oxo-1,2-dihydro-quinoline-4-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide; N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide; CHEMBL4871450; N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-2-oxoquinoline-4-carboxamide; SCHEMBL20942221; BCP25037; EX-A1816; BDBM50572136; s8329; AKOS027600530; CeMMEC13, >=98% (HPLC); CCG-267868; AC-35506; BS-15617; HY-101088; CS-0020799; C73404; A924884; Z441586532; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide. Grade: ≥98%. CAS No. 1790895-25-8. Molecular formula: C19H16N2O4. Mole weight: 336.3. | |
| CeMMEC1 hydrochloride | CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (Kd = 1.8 μM; IC50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. CeMMEC1 can also inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. Synonyms: CeMMEC1 HCl. Grade: ≥98%. CAS No. 2095432-53-2. Molecular formula: C19H17ClN2O4. Mole weight: 372.8. | |
| Cendakimab | Cendakimab is a humanized monoclonal antibody directed against IL-13. Cendakimab targets IL-13 and inhibits its binding to both IL-13-receptor specific subtypes (IL-13-Rα1 and IL-13-Rα2). Cendakimab has been used in the research of eosinophilic esophagitis. Synonyms: RPC-4046; RPC 4046; RPC4046; ABT-308; ABT 308; ABT308; CC-93538; CC 93538; CC93538. Grade: 95%. CAS No. 2151032-62-9. | |
| Cenegermin | Cenegermin is a recombinant human nerve growth factor that has the healing effect on eye and repair corneal damage. It was granted orphan drug designation in 2015. Uses: Repair corneal damage. CAS No. 1772578-74-1. Molecular formula: C583H908N166O173S8. Mole weight: 13266.94. | |
| Cenerimod | Cenerimod is an active Lysosphingolipid receptor agonist originated by Actelion Pharmaceuticals and EC50 value is 2.7 nM. It is a S1P1/EDG1 receptor agonist and has a long-lasting immunomodulating effect through reducing the number of circulating and infiltrating T- and B-lymphocytes, without affecting their maturation, memory, or expansion. Cenerimod is in phase I/II clinical trials for the treatment of Systemic lupus erythematosus. Uses: Systemic lupus erythematosus. Synonyms: ACT-334441; ACT334441; ACT 334441; (S)-3-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol. Grade: 98%. CAS No. 1262414-04-9. Molecular formula: C25H31N3O5. Mole weight: 453.54. | |
| Cenicriviroc | Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell as an experimental drug candidate for the treatment of HIV infection. Uses: Ccr2 receptor antagonists; ccr5 receptor antagonists. Synonyms: (S,E)-8-(4-(2-Butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide; TAK-652; TAK652; TAK 652; TBR-652; TBR 652; TBR652; Cenicriviroc. Grade: ≥98%. CAS No. 497223-25-3. Molecular formula: C41H52N4O4S. Mole weight: 696.95. | |
| Cenicriviroc mesylate | Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell as an experimental drug candidate for the treatment of HIV infection. Synonyms: TAK-652 mesylate; TAK 652 mesylate; TBR-652 mesylate; TBR 652 mesylate. Grade: 99.04%. CAS No. 497223-28-6. Molecular formula: C42H56N4O7S2. Mole weight: 793.051. | |
| Cenicriviroc Sulfone | Cenicriviroc Sulfone is a derivative of Cenicriviroc which is an experimental drug candidate for the treatment of HIV infection. It is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. Synonyms: 8-[4-(2-Butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4-[[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-1-benzazocine-5-carboxamide; 8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-[4-[[(1-propyl-1H-imidazol-5-yl)methyl]sulfonyl]phenyl]-1. Grade: > 95%. CAS No. 497223-22-0. Molecular formula: C41H52N4O5S. Mole weight: 712.96. | |
| Cenisertib | R763 is an orally bioavailable, synthetic, small-molecule multi-Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor R763 selectively binds to and inhibits multiple Aurora kinases (AKs), which may result in the inhibition of cell division and proliferation, and the induction of apoptosis in tumor cells that overexpress AKs. Overexpressed in certain tumor cell types, AKs, a family of serine-threonine kinases, are important regulators of cell division and proliferation that are involved in controlling chromatid segregation. Synonyms: AS703569; AS 703569; AS-703569; R763; R 763; R-763. CAS No. 871357-89-0. Molecular formula: C24H30FN7O. Mole weight: 451.55. | |
| Censavudine | Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people with multi-drug resistant (MDR) strains of the virus. It is a derivative of stavudine (d4T), but is less toxic. It has demonstrated potent in vitro activity against HIV-2. It was developed by Bristol Myers-Squibb and in clinic phase 2 trials. Uses: Censavudine is active against hiv resistant to both abacavir and tenofovir. Synonyms: OBP-601; OBP601; OBP 601; BMS-986001; BMS 986001; BMS986001; festinavir; 4'-Ed4T; 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine; 4'-Ethynyl D4T. Grade: 95%. CAS No. 634907-30-5. Molecular formula: C12H12N2O4. Mole weight: 248.24. | |
| Centanafadine | Centanafadine is a dual norepinephrine-dopamine transporter inhibitor used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Synonyms: EB-1020 free base; DOV 216,419 free base; (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane. CAS No. 924012-43-1. Molecular formula: C15H15N. Mole weight: 209.29. | |
| Centanafadine Hydrochloride | Centanafadine Hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) used as a treatment for attention deficit hyperactivity disorder (ADHD) which is in phase II clinical trials. Synonyms: DOV 216419 Hydrochloride; EB 1020 Hydrochloride; (1R,5S)-1-(2-Naphthalenyl)-3-azabicyclo[3.1.0]hexane Hydrochloride. CAS No. 923981-14-0. Molecular formula: C15H16ClN. Mole weight: 245.75. | |
| Centanafadine Lactam | Centanafadine Lactam is an impurity or metabolite of Centanafadine, which is a dual norepinephrine-dopamine transporter inhibitor used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Synonyms: (1S,5R)-5-(2-Naphthyl)-3-azabicyclo[3.1.0]hexan-2-one; 3-Azabicyclo[3.1.0]hexan-2-one, 5-(2-naphthalenyl)-, (1S,5R)-. Molecular formula: C15H13NO. Mole weight: 223.27. | |
| Centhaquine | Centhaquin is a new type of drug with the potential to treat hemorrhagic shock. Synonyms: Centhaquin; Compound-7173; PMZ-2010; PMZ-2010. Grade: 98%. CAS No. 57961-90-7. Molecular formula: C22H25N3. Mole weight: 331.5. | |
| Centrinone | Centrinone, a pyrimidinamine derivative, has been found to be a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Synonyms: Centrinone; LCR-263; LCR 263; LCR263. 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine. Grade: ≥98% by HPLC. CAS No. 1798871-30-3. Molecular formula: C26H25F2N7O6S2. Mole weight: 633.65. | |
| Centrinone B | Centrinone B, has been found to be a high affinity and selective PLK4 inhibitor (Ki: 0.6 nM) and exhibit more than 2000-fold selectivity for PLK4 over Aurora A and Aurora B. Synonyms: Centrinone-B; Centrinone B; CentrinoneB; LCR-323; LCR 323; LCR323; 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine. Grade: ≥98% by HPLC. CAS No. 1798871-31-4. Molecular formula: C27H27F2N7O5S2. Mole weight: 631.67. | |
| CEP-11981 | CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57. | |
| CEP 1347 | CEP 1347, also named KT 7515 or CHEMBL290352, an ethylthiomethyl derivative, is a potent, selective inhibitor of the cJun-amino terminal kinase pathway currently under clinical evaluation for the treatment of neurodegenerative diseases. It blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CHEMBL290352; CEP-1347; 3,9-Bis(etsm)-K-252a; CEP1347; 156177-65-0; CEP 1347; KT7515; 3,9-Bis((ethylthio)methyl)-K-252a; KT 7515; KT-7515; GTPL8173; SCHEMBL12047710; BDBM24942; CEP1374; CEP 1374; CEP-1374; ZINC3928304; AKOS024458422; KT-1575; 170587-65-2; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 5,16-bis((ethylthio)methyl)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S-(9alpha,10beta,12alpha))-; CEP 1347|(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester; methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)methyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate. CAS No. 156177-65-0. Molecular formula: C33H33N3O5S2. Mole weight: 615.76. | |
| CEP-14083 | CEP-14083 is a ALK inhibitor. It has a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L). CEP-14083 can also inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed it can control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. Synonyms: CEP14083; CEP 14083; CEP-14083. 1-methyl-3-(4-methyl-6-oxo-13-propyl-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl)-1-phenylurea. Grade: 98%. CAS No. 856692-39-2. Molecular formula: C31H30N6O2. Mole weight: 518.61. | |
| CEP-14513 | CEP-14513 is a ALK inhibitor. It shows ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM). Synonyms: CEP14513; CEP 14513; CEP-14513. 13-isobutyl-4-methyl-6-oxo-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl 4-(dimethylamino)benzylcarbamate. Grade: 98%. CAS No. 856693-04-4. Molecular formula: C34H36N6O3. Mole weight: 576.69. | |
| CEP-1612 | CEP-1612, a dipeptidyl proteasome inhibitor, induces apoptosis and inhibits tumor growth of the human lung cancer cell line A-549 in an in vivo model. Synonyms: N-[(2S)-5-[[amino(nitramido)methylidene]amino]-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]-2-cyclopentyl-10-(1,3-dioxoisoindol-2-yl)decanamide; CEP-1612; CEP 1612; CEP1612; UNII-9K6U075027. Grade: >98%. CAS No. 189036-01-9. Molecular formula: C35H53N7O7. Mole weight: 683.84. | |
| CEP-28122 | CEP-28122 is a highly potent and selective oral anaplastic lymphoma kinase inhibitor with antitumor activity in experimental human cancer models. Synonyms: CEP 28122; CEP28122; Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-; (1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide. Grade: ≥95%. CAS No. 1022958-60-6. Molecular formula: C28H35ClN6O3. Mole weight: 539.07. | |
| CEP-28122 mesylate salt | CEP-28122 mesylate salt is a highly selective orally active ALK inhibitor (IC50 = 1.9 nM). CEP-28122 has antitumor activity in experimental models of ALK-positive human cancers. Synonyms: Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-, methanesulfonate (1:1); CEP-28122 methanesulfonic acid; (1S,2S,3R,4R)-3-((5-chloro-2-(((S)-1-methoxy-7-morpholino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide methanesulfonic acid; CEP28122 mesylate salt; CEP 28122 mesylate salt. Grade: 99%. CAS No. 2070009-30-0. Molecular formula: C29H39ClN6O6S. Mole weight: 635.17. | |
| CEP-32496 | CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2. Synonyms: 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea; RXDX-105; RXDX 105; RXDX105; CEP32496; CEP-32496; CEP 32496; AC013773; AC 013773; AC-013773 Agerafenib. Grade: >98%. CAS No. 1188910-76-0. Molecular formula: C24H22F3N5O5. Mole weight: 517.46. | |
| CEP-32496 hydrochloride | CEP-32496, also known as AC013773, is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. CEP-32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase. This inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene. The Raf mutation BRAF V600E, in which valine is substituted for glutamic acid at residue 600, is frequently found in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Synonyms: CEP-32496; CEP32496; CEP 32496; AC013773; AC 013773; AC-013773. CAS No. 1227678-26-3. Molecular formula: C24H23ClF3N5O5. Mole weight: 553.92. | |
| CEP33779 | CEP-33779 is a highly selective, orally active inhibitor of JAK2. It induces regression of established colorectal tumors, angiogenesis, and proliferation of tumor cells. Synonyms: CEP-33779; N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine. Grade: >98%. CAS No. 1257704-57-6. Molecular formula: C24H26N6O2S. Mole weight: 462.572. | |
| CEP-37440 | CEP-37440 is an orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis. Synonyms: CEP-37440; CEP 37440; CEP37440. CAS No. 1391712-60-9. Molecular formula: C30H38ClN7O3. Mole weight: 580.12. | |
| CEP-40783 | CEP-40783 is an orally-active, nanomolar potent and highly kinase-selective Type II inhibitor of the AXL and c-Met RTK with IC50 values of 7 nM and 12 nM, respectively. Synonyms: N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; CEP40783; CEP 40783; CEP-40783; RXDX-106; RXDX 106; RXDX106. CAS No. 1437321-24-8. Molecular formula: C31H26F2N4O6. Mole weight: 588.56. | |
| CEP-5214 | CEP-5214 is a potent, low-nanomolar pan inhibitor of human VEGF-R tyrosine kinases, displaying IC(50) values of 16, 8, and 4 nM for VEGF-R1/FLT-1, VEGF-R2/KDR, and VEGF-R3/FLT-4, respectively, with cellular activity equivalent to the isolated enzyme activity. Compound 21 exhibited good selectivity against numerous tyrosine and serine/threonine kinases including PKC, Tie2, TrkA, CDK1, p38, JNK, and IRK. Synonyms: CEP 5214; CEP5214; 3-(5,6,7,13-tetrahydro-9-((1-methylethoxy)methyl)-5-oxo-12h-indeno(2,1-a)pyrrolo(3,4-c)carbazol-12-yl)propanol; 12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-5-one. CAS No. 402857-39-0. Molecular formula: C28H28N2O3. Mole weight: 440.54. | |
| CEP-6800 | CEP-6800 is a potent PARP inhibitor with potential anticancer activity. CEP-6800 could be used as a chemopotentiating agent with a variety of clinically effective chemotherapeutic agents. Synonyms: CEP 6800; CEP6800; 10-(aminomethyl)-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione; 8-aminomethyl-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione. Grade: 98%. CAS No. 609848-02-4. Molecular formula: C18H15N3O2. Mole weight: 305.34. | |
| CEP-7055 | CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65. | |
| CEP-9722 | CEP-9722 is a small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA. Synonyms: CEP 9722; CEP9722; 11-methoxy-2-((4-methylpiperazin-1-yl)methyl)-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione. CAS No. 916574-83-9. Molecular formula: C24H26N4O3. Mole weight: 418.49. | |
| Cephalexin Diketopiperazine | A degradation product of Cephalosporins. Synonyms: 2-(3,6-Dioxo-5-phenyl-2-piperazinyl)-3,6-dihydro-5-methyl-2H-1,3-thiazine-4-carboxylic Acid. Grade: > 95%. CAS No. 59865-11-1. Molecular formula: C16H17N3O4S. Mole weight: 347.4. | |
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