BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CCT-251236 | CCT-251236 is an orally active Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen, which exhibited efficacy in a human ovarian carcinoma xenograft model. Uses: The potential treatment of ovarian carcinoma. Synonyms: CCT251236; CCT 251236; N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide; N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide; 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-. Grade: ≥95%. CAS No. 1693731-40-6. Molecular formula: C32H32N4O5. Mole weight: 552.62. |  |
| CCT251545 | CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the human Mediator complex-associated protein kinases CDK8 and CDK19 over 291 other kinases. IC50: Synonyms: 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneCCT251545; CCT 251545; CCT-251545; CHEMBL34082138-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)ph. CAS No. 1661839-45-7. Molecular formula: C23H24ClN5O. Mole weight: 421.92. | |
| CCT-251921 | CCT-251921 has been found to be a CDK inhibitor that could be significant in the studies of colorectal cancer. Synonyms: CCT251921; CCT-251921; CCT 251921; 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one. Grade: 98%. CAS No. 1607837-31-9. Molecular formula: C21H23ClN6O. Mole weight: 410.91. | |
| CCTA-1523 | CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor with anticancer activity. It selectively reverses ABCG2-mediated MDR in cancer cells. Synonyms: Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-; 2,2-Dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)acetamide. Grade: ≥95%. CAS No. 1616271-41-0. Molecular formula: C16H15Cl2NO3. Mole weight: 340.20. | |
| CCX140-B | CCX140-B is a potent CCR2 antagonist. Synonyms: CCX140; Ilacirnon. CAS No. 1100318-47-5. Molecular formula: C20H13ClF3N5O3S. Mole weight: 495.9. | |
| CD12681 | CD12681 is a potent and selective RORγ inverse agonist with IC50 of 19 nM. CD12681 was indentified as a preclinical candidate for the topical treatment of psoriasis. Synonyms: N-(2,4-Dimethylphenyl)-N-isobutyl-2-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide. Grade: 99%. CAS No. 1952239-59-6. Molecular formula: C25H33N3O4S. Mole weight: 471.61. | |
| CD1530 | CD1530 is a potent and selective retinoic acid receptor(RAR) agonist with Ki values of 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively. It was also a potent CYP26A1 inhibitor as ketoconazole with an IC50 value of 530 nM. It inhibited excessive ROS production in tongue epithelial cells in vitro. It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM. It has been shown to preserve human tendon stem cell characteristics, promote repair of injured skeletal muscle, and in combination with bexarotene to inhibit oral carcinogenesis. Synonyms: 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid; CD 1530; CD-1530; Benzoic acid, 4-(6-hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)-; 4-[7-(Adamantan-1-yl)-6-hydroxy-2-naphthyl]benzoic acid. Grade: ≥95%. CAS No. 107430-66-0. Molecular formula: C27H26O3. Mole weight: 398.49. | |
| CD161 | CD161 is a potent, selective and orally active BET bromodomain inhibitor with Ki values of 8.2 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. In human leukemia cell lines MV4-11 and MOLM-13, CD161 strongly inhibits cell growth and induces apoptosis, with IC50s <100 nM. Synonyms: CD-161; CD 161; 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole. Grade: 98%. CAS No. 1627716-22-6. Molecular formula: C26H21N5O2. Mole weight: 435.48. | |
| CD 2314 | CD 2314 is a potent and selective RARβ receptor agonist (Kd = 145 and >3760 nM for RARβ and RARα receptors, respectively). Synonyms: CD-2314; CD 2314; CD2314; 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid. Grade: ≥98% by HPLC. CAS No. 170355-37-0. Molecular formula: C23H24O2S. Mole weight: 364.5. | |
| CD235 | CD235 is a structurally similar analogue of CD161, which is a potent and orally bioavailable inhibitor of BET bromodomain. Synonyms: 7-(3,5-Dimethyl-1,2-oxazol-4-yl)-4-(6-fluoro-4-quinolinyl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indole; 9H-Pyrimido[4,5-b]indole, 7-(3,5-dimethyl-4-isoxazolyl)-4-(6-fluoro-4-quinolinyl)-6-methoxy-2-methyl-. Grade: ≥95%. CAS No. 1627716-57-7. Molecular formula: C26H20FN5O2. Mole weight: 453.47. | |
| CD 2665 | CD 2665 is a selective RARβ and RARγ antagonist (KD = 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively) with no activity at RXRα. CD 2665 is used to abrogate retinoic acid-induced apoptosis, proliferation and differentiation of sebocyte growth. Synonyms: CD2665; CD 2665; CD-2665. 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid. Grade: ≥98% by HPLC. CAS No. 170355-78-9. Molecular formula: C31H34O5. Mole weight: 486.6. | |
| CD 3254 | CD 3254 is a selective RXRα agonist with no activity at RARα, RARβ or RARγ receptors. Synonyms: CD3254; CD 3254; CD-3254. 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid. Grade: ≥97% by HPLC. CAS No. 196961-43-0. Molecular formula: C24H28O3. Mole weight: 364.48. | |
| CD38 inhibitor 1 | CD38 inhibitor 1 is a potent CD38 inhibitor. Synonyms: CD38-IN-78c; MDK-7553. CAS No. 1700637-55-3. Molecular formula: C22H27N3O3S. Mole weight: 413.53. | |
| CD40-TRAF6 inhibitor | A CD40-TRAF6 interaction inhibitor. Synonyms: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one. CAS No. 433249-94-6. Molecular formula: C17H17NO. Mole weight: 251.32. | |
| CD532 hydrochloride | CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride can also directly interact with AURKA and induces a global conformational shift. Synonyms: CD532 (hydrochloride); CD532 hydrochloride; EX-A8075A; HY-112273A; MS-30172; CS-0202740; 2926498-81-7. Grade: 99%. Molecular formula: C26H26ClF3N8O. Mole weight: 558.99. | |
| CD73-IN-1 | CD73-IN-11 is a CD73 inhibitor with an IC50 of ≤316.23 nM for the human enzyme in a cell-free assay. It can be used in cancer treatment. (Extracted from patent WO 2017153952 A1, example 80). Synonyms: VPS34 inhibitor; 5-[N-(2-Cyclopropyl-6-indolyl)sulfamoyl]-2-hydroxybenzamide; CD73 inhibitor 1; Benzamide, 5-[[(2-cyclopropyl-1H-indol-6-yl)amino]sulfonyl]-2-hydroxy-. Grade: ≥98%. CAS No. 2132396-40-6. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| CD73-IN-2 | CD73-IN-2 is a potent CD73 inhibitor with an IC50 of 0.09 nM. Synonyms: ((((2R,3S,4R,5R)-5-((6-chloro-4-(cyclopentylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)phosphonic acid. Molecular formula: C17H25ClN5O7P. Mole weight: 477.84. | |
| CD73-IN-4 | CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor with an IC50 of 2.6 nM for human. It has potential in cancer immunology research. Synonyms: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-; 6-Chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grade: ≥97%. CAS No. 2216764-29-1. Molecular formula: C16H23ClN5O7P. Mole weight: 463.81. | |
| CD73-IN-5 | CD73-IN-5 is a potent and selective non-nucleotide small molecule CD73 inhibitor with an IC50 of 19 nM. Synonyms: Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-. CAS No. 2412019-99-7. Molecular formula: C24H15FN8. Mole weight: 434.43. | |
| Cdc7-IN-1 | Cdc7-IN-1 is a highly potent, selective and ATP competitive Cdc7 kinase inhibitor, with an IC50 of 0.6 nM at 1 mM ATP and a slow deceleration characteristic. It can effectively inhibit the activity of Cdc7 in cancer cells and induce cell death. Synonyms: Ethyl (5Z)-2-[(2-chlorophenyl)amino]-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 2-[(2-chlorophenyl)amino]-4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, ethyl ester, (5Z)-. Grade: ≥99%. CAS No. 1402055-25-7. Molecular formula: C21H16ClN3O4. Mole weight: 409.82. | |
| Cdc7-IN-3 | Cdc7-IN-3, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-B). Synonyms: Isopropyl (5Z)-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, 1-methylethyl ester, (5Z)-. Grade: ≥95%. CAS No. 1402057-87-7. Molecular formula: C20H22N4O5. Mole weight: 398.41. | |
| Cdc7-IN-4 | Cdc7-IN-4, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-C). Synonyms: Isopropyl (5Z)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-{[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino}-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-[[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino]-, 1-methylethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402059-21-5. Molecular formula: C22H24F3N5O4. Mole weight: 479.45. | |
| Cdc7-IN-5 | Cdc7-IN-5, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-B). Synonyms: Ethyl (5Z)-2-(7-methoxy-3,4-dihydro-2(1H)-isoquinolinyl)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 2-(3,4-dihydro-7-methoxy-2(1H)-isoquinolinyl)-4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, ethyl ester, (5Z)-. Grade: ≥95%. CAS No. 1402057-86-6. Molecular formula: C25H23N3O5. Mole weight: 445.47. | |
| Cdc7-IN-6 | Cdc7-IN-6 is a potent Cdc7 kinase inhibitor (IC50 = 4 nM) with antitumor activity. (Extracted from patent WO2019165473A1, compound I-D). Synonyms: AS-0141; Ethyl (5Z)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-{[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino}-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-[[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino]-, ethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402057-88-8. Molecular formula: C21H22F3N5O4. Mole weight: 465.43. | |
| Cdc7-IN-7 | Cdc7-IN-7, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-E). Synonyms: Cyclopropylmethyl (5Z)-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, cyclopropylmethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402059-17-9. Molecular formula: C21H22N4O5. Mole weight: 410.42. | |
| CDC801 | A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM). Synonyms: CDC801; CDC 801; CDC-801; 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide. CAS No. 192819-27-5. Molecular formula: C23H24N2O5. Mole weight: 408.45. | |
| CDD0102 | CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. administration in rodents. Synonyms: CDD0102; CDD 0102; CDD-0102; 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole; 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine; CDD-0102A. CAS No. 146422-58-4. Molecular formula: C8H12N4O. Mole weight: 180.21. | |
| CDD3505 | CDD3505 is an inducer of hepatic cytochrome P450IIIA (CYP3A) activity that elevates high density lipoprotein cholesterol (HDL). Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 4-Nitro-1-trityl-1H-imidazole; 1-Trityl-4-nitroimidazole. CAS No. 173865-33-3. Molecular formula: C22H17N3O2. Mole weight: 355.39. | |
| CDDD3602 | Tematropium, a neurological agent, is a soft anticholinergic drug. Synonyms: Tematropium; HGP6; Tematropium methylsulfate; Tematropium metilsulfate; 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium methyl sulfate (salt), (±)-ethyl hydrogen phenylmalonate; 8-Azoniabicyclo(3.2.1)octane, 3-(3-ethoxy-1,3-dioxo-2-phenylpropoxy)-8,8-dimethyl-, endo-(±)-, methyl sulfate; (3-endo)-3-[(3-Ethoxy-3-oxo-2-phenylpropanoyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane methyl sulfate. Grade: ≥95%. CAS No. 113932-41-5. Molecular formula: C21H31NO8S. Mole weight: 457.54. | |
| CDDO-2-P-Im | CDDO-2-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-2P-Im. Grade: 98%. CAS No. 1883650-96-1. Molecular formula: C39H46N4O3. Mole weight: 618.8. | |
| CDDO-3-P-Im | CDDO-3-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-3P-Im. Grade: 98%. CAS No. 1883650-95-0. Molecular formula: C39H46N4O3. Mole weight: 618.8. | |
| CDDO-DhTFEA | CDDO-DhTFEA can effectively activate Nrf2 and inhibit the pro-inflammatory transcription factor NF-κB. Synonyms: RTA Dh404; RTA Dh404RTA Dh404. CAS No. 1191265-33-4. Molecular formula: C33H45F3N2O3. Mole weight: 574.7. | |
| CDDO-EA | CDDO-EA is an activator of Nrf2/ARE. It has neuroprotective effect. Synonyms: CDDO ethyl amide; RTA405; TP319; RTA 405; TP 319; RTA-405; TP-319. Grade: >98%. CAS No. 932730-51-3. Molecular formula: C33H46N2O3. Mole weight: 518.73. | |
| CDDO Imidazolide | CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Synonyms: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; (4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile. Grade: ≥98 %. CAS No. 443104-02-7. Molecular formula: C34H43N3O3. Mole weight: 541.72. | |
| CDDO-TFEA | CDDO-TFEA is an Nrf2/ARE pathway activator. CDDO-TFEA inhibits BACH1 via reducing BACH1 nuclear levels while accumulating its cytoplasmic form. Synonyms: 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide; CDDO-trifluoroethyl-amide. CAS No. 932730-52-4. Molecular formula: C33H43F3N2O3. Mole weight: 572.7. | |
| CDDU-Me | CDDU-Me is an activator of the Nrf2 pathway, which induces the expression of cytoprotective genes regulated by Nrf-2 in vivo. It has anti-inflammatory, anti-tumor and cell protection properties. Synonyms: AC-31539. CAS No. 1616932-17-2. Molecular formula: C32H43NO4. Mole weight: 505.7. | |
| c-di-2'-d-2''-O-Me-AMP | c-di-2'-d-2''-O-Me-AMP is an analogue of c-diAMP, the bacterial second messenger. Synonyms: 2'- Deoxy- 2''- O- methyl- cyclic diadenosine monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C21H26N10O11P2 (free acid). Mole weight: 656.5 (free acid). | |
| c-di-2'-dAMP | c-di-2'-dAMP is an analogue of c-diAMP, the bacterial second messenger. Synonyms: 2'- Deoxy- cyclic diadenosine monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2 (free acid). Mole weight: 642.4 (free acid). | |
| c-di-2'-dGMP | c-di-2'-dGMP is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Synonyms: 2'- Deoxy- cyclic diguanosine monophosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 132182-18-4. Molecular formula: C20H24N10O13P2 (free acid). Mole weight: 674.4 (free acid). | |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide. Grade: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| c-di-AMP diammonium | c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, diammonium; Adenylic acid, cyclic ester diammonium; 3',5'-Cyclic diadenylic acid diammonium; Cyclic di-3',5'-adenylate diammonium; Cyclic diadenylate monophosphate diammonium; (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide diammonium. Grade: ≥95%. Molecular formula: C20H30N12O12P2. Mole weight: 692.47. | |
| c-di-AMP disodium | c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. It activates STING-dependent IFN-β production in mouse and human cells. Synonyms: 3',5'-Cyclic diadenylic acid sodium salt; Cyclic diadenylate disodium; Cyclic-di-AMP disodium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, disodium; Adenylic acid, cyclic ester disodium; 3',5'-Cyclic diadenylic acid disodium; Cyclic di-3',5'-adenylate disodium; Cyclic diadenylate monophosphate disodium. CAS No. 2734909-87-4. Molecular formula: C20H22N10Na2O12P2. Mole weight: 702.38. | |
| c-di-AMP sodium | c-di-AMP sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. Synonyms: Cyclic diadenylate sodium; Cyclic-di-AMP sodium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, sodium; Adenylic acid, cyclic ester sodium; 3',5'-Cyclic diadenylic acid sodium; Cyclic di-3',5'-adenylate sodium; Cyclic diadenylate monophosphate sodium. Grade: ≥95%. Molecular formula: C20H24N10O12P2.xNa. Mole weight: 658.41 (free acid). | |
| CDIBA | CDIBA is a potent and selective cytosolic phospholipase A2 (cPLA2) inhibitor. Synonyms: 4-[2-(1-benzhydryl-5-chloro-2-methylindol-3-yl)ethoxy]benzoic acid. Grade: 99%. CAS No. 479422-22-5. Molecular formula: C31H26ClNO3. Mole weight: 496. | |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP; cGpGp; Cyclic diguanylic acid; cdiGMP; 3',5'-Cyclic diguanylic acid; c-(Gpgp); Bis(3',5')-cyclic diguanylic acid. Grade: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| c-di-GMP Fluorinated | A STING agonist. CAS No. 1334145-18-4. Molecular formula: C20H20F2N10O12P2.2Na. Mole weight: 738.36. | |
| c-di-IMP | c-diIMP is an analogue of c-diAMP and c-diGMP, the bacterial second messengers, which is potentially used as an adjuvant for mucosal vaccination. Synonyms: Cyclic diinosine monophosphate; 3'-Inosinic acid, inosinylyl-(3'→5')-, cyclic nucleotide; Cyclic-di-IMP; 3',3'-Cdimp; 9,9'-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine-2,9-diyl)bis(1,9-dihydro-6H-purin-6-one). Grade: ≥95% by HPLC. CAS No. 79940-41-3. Molecular formula: C20H22N8O14P2. Mole weight: 660.38. | |
| C-DIM12 | C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Synonyms: C-DIM 12; C-DIM-12. Grade: 98%. CAS No. 178946-89-9. Molecular formula: C23H17ClN2. Mole weight: 356.85. | |
| c-di-UMP | A STING agonist negative control. Synonyms: Cyclic di-uridine monophosphate, c-di-UMP sodium salt. CAS No. 73120-97-5. Molecular formula: C18H20N4O16P2.2Na. Mole weight: 656.3. | |
| CDK12-IN-2 | CDK12-IN-2, a potent and selective nanomolar CDK12 inhibitor (IC50 = 52 nM) with good physicochemical properties, inhibits phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II, and can be used as an excellent chemical probe for the study of CDK12 function. It is also a strong CDK13 inhibitor because CDK13 is the closest homologue of CDK12. It shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. Synonyms: Urea, N-[trans-4-[(5-cyano-2-pyridinyl)amino]cyclohexyl]-N-[4-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)phenyl]-N'-(phenylmethyl)-; 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea. CAS No. 2244987-03-7. Molecular formula: C32H32N6O2. Mole weight: 532.64. | |
| CDK12-IN-4 | CDK12-IN-4 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 0.641 μM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM). (WO2021116178A1). Synonyms: Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-. CAS No. 2651196-69-7. Molecular formula: C20H20F2N8O. Mole weight: 426.42. | |
| CDK12-IN-5 | CDK12-IN-5 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 23.9 nM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50 = 173 μM) and CDK9/Cyclin T1 (IC50 = 127 μM). (WO2021116178A1). Synonyms: Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-. CAS No. 2651200-35-8. Molecular formula: C18H15F5N8O. Mole weight: 454.36. | |
| CDK12-IN-6 | CDK12-IN-6 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 1.19 μM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM). (WO2021116178A1). Synonyms: 8-cyclopropyl-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-(piperazin-1-yl)pyrazolo[1,5-a][1,3,5]triazin-4-amine. CAS No. 2651196-71-1. Molecular formula: C20H21F2N9. Mole weight: 425.44. | |
| Cdk1/2 Inhibitor III | Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 of 2.1 μM for CDK1/cyclin B. It is a cell-permeable triazolo-diamine compound with anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa and A375 cells, respectively). Synonyms: Cyclin-dependent Kinase 1/2 Inhibitor III; 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-; 3-Amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide; 3-amino-N-(2,6-difluorophenyl)-5-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide. Grade: >95%. CAS No. 443798-55-8. Molecular formula: C15H13F2N7O2S2. Mole weight: 425.44. | |
| CDK1 Inhibitor | Cdk1 inhibitor is a cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties with IC50 of 2 μM. Cdk1 inhibitor acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B with IC50 of 5.8 μM. It also inhibits Cdk5 with IC50 of 25 μM. Synonyms: Cyclin-dependent Kinase 1 Inhibitor. Grade: ≥95%. CAS No. 220749-41-7. Molecular formula: C17H11ClN2O. Mole weight: 294.7. | |
| Cdk2/9 Inhibitor | Cdk2/9 inhibitor is an inhibitor used for the synthesis of Nek1 inhibitors BSc5231 and BSc5367. Synonyms: CK7; 4-(2-Amino-4-methyl-5-thiazolyl)-N-(3-nitrophenyl)-2-pyrimidinamine; [4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine; 4-(2-Amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)-2-pyrimidinamine. Grade: 95%. CAS No. 507487-89-0. Molecular formula: C14H12N6O2S. Mole weight: 328.34. | |
| CDK2-IN-7 | CDK2-IN-7 is a cyclin-dependent kinases 2 (CDK2) inhibitor (IC50 <50 nM) for the treatment of cancer. Synonyms: Benzenesulfonamide, 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-[5H]pyrrolo[2,3-d]pyrimidine]-2'(7'H)-yl]amino]-N-(3-methyl-3-azetidinyl)-, rel-; 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-2'-yl]amino]-N-(3-methylazetidin-3-yl)benzenesulfonamide. CAS No. 2498658-13-0. Molecular formula: C24H30N6O4S. Mole weight: 498.60. | |
| CDK2-IN-73 | CDK2-IN-73 is a potent and selective inhibitor of CDK2 with IC50 of 44 nM for CDK2. Synonyms: CDK2 inhibitor 73; CDK2-IN-4. CAS No. 2079895-42-2. Molecular formula: C23H18N6O2S. Mole weight: 442.49. | |
| CDK2 Inhibitor II | The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. It is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 with IC50 of 60 nM. Synonyms: Cyclin-dependent kinase 2 Inhibitor II; SC-221409. Grade: ≥95%. CAS No. 222035-13-4. Molecular formula: C14H11BrN4O3S. Mole weight: 395.2. | |
| CDK4/6/1 Inhibitor | CDK4/6/1 Inhibitor is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1. Synonyms: 5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-[3H]indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-. Grade: ≥96%. CAS No. 2099128-41-1. Molecular formula: C28H30F2N6. Mole weight: 488.57. | |
| CDK4/6-IN-2 | CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM, respectively. (Extracted from patent US20180000819A1, Compound 1). Synonyms: 5-[(4-Ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzimidazol-6-yl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-. Grade: ≥97%. CAS No. 1800506-48-2. Molecular formula: C27H32F2N8. Mole weight: 506.59. | |
| CDK4/6-IN-3 | CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 and 2.2 nM, respectively. It can be used for the treatment of glioblastoma. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. Synonyms: 2-Pyrimidinamine, N-[5-(6-ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-5,6,7,8-tetrahydro-4-methyl-4H-pyrazolo[1,5-a]azepin-3-yl]-; N-[5-(6-Ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]-2-pyrimidinamine. Grade: ≥97%. CAS No. 2366237-37-6. Molecular formula: C25H31FN8. Mole weight: 462.57. | |
| CDK4/6-IN-5 | CDK4/6-IN-5 is a potent inhibitor of CDK4 and CDK6 with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (Extracted from patent WO2019207463A1, example A93). Synonyms: 1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-. Grade: 96%. CAS No. 2380321-50-4. Molecular formula: C22H28ClFN6O4S. Mole weight: 527.01. | |
| CDK4/6 Inhibitor IV | Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine inhibitor for Cdk4/cyclin D1 with IC50 values of 1.5 μM and Cdk6/cyclin D1 with IC50 values of 5.6 μM. It exhibits blocking of pRb phosphorylation at Ser780 and Ser795. Cdk4/6 inhibitor IV can suppresses tumor growth in Xenograft mouse model. Synonyms: CINK4; Cyclin-dependent kinase 4/6 Inhibitor IV. Grade: ≥98%. CAS No. 359886-84-3. Molecular formula: C27H32N6O. Mole weight: 456.6. | |
| CDK4-IN-1 | CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. Synonyms: CDK4 IN 1; LEE011 analog; CDK4-IN-1; CDK4IN-1; CDK4-IN1; CDK4IN1; CDK4 IN 1; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine. Grade: >98%. CAS No. 1256963-02-6. Molecular formula: C22H29ClN8. Mole weight: 440.97. | |
| CDK4 Inhibitor | Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 of 0.8 μM. It also inhibits the activity of other Cdk's only at much higher concentrations (IC50 = 520 nM and 2.1 μM for Cdk2/E and Cdk1/B, respectively). Cdk4 inhibitor can inhibit tumor cells growth in HCT-116 and NCI-H460 cells (IC50 < 3.0 μM). Synonyms: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grade: ≥90%. CAS No. 546102-60-7. Molecular formula: C20H10BrN3O2. Mole weight: 404.22. | |
| CDK5-IN-1 | CDK5-IN-1 is a potent CDK5 inhibitor with an activity of less than 10 nM against CDK5. It is used in kidney diseases research. Synonyms: 1H-Pyrazole-3-methanol, 1-[3-fluoro-4-[[2-[(1-methyl-4-piperidinyl)sulfonyl]-1,6-naphthyridin-7-yl]amino]phenyl]-. CAS No. 2639540-19-3. Molecular formula: C24H25FN6O3S. Mole weight: 496.56. | |
| CDK5 inhibitor 20-223 | CDK5 inhibitor 20-223, an effective anti-colorectal cancer (CRC) agent, is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. Synonyms: 2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-; CDK5-IN-20-223; N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(2-naphthyl)acetamide. Grade: ≥99%. CAS No. 865317-30-2. Molecular formula: C19H19N3O. Mole weight: 305.37. | |
| CDK6/9-IN-1 | CDK6/9-IN-1 is an orally active dual inhibitor of CDK6 and CDK9, with IC50s of 40.5 and 39.5 nM, respectively. Synonyms: Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-. CAS No. 2414373-55-8. Molecular formula: C22H25ClN8O. Mole weight: 452.94. | |
| CDK7/9-IN-1 | CDK7/9-IN-1 is a CDK7/9 inhibitor that can be used in cancer research, selectively inhibiting CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Synonyms: 2-Propen-1-one, 1-[(2R)-2-[[4-[[3-(1-methylethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl]amino]-1-piperidinyl]methyl]-4-morpholinyl]-. CAS No. 2747919-19-1. Molecular formula: C24H32F3N5O2. Mole weight: 479.54. | |
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