BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| CC4 | CC4 is a selective α6β2 and α4β2 nAChR partial agonist (Ki = 12 and 26nM for rat α6β2 and α4β2 receptors, respectively). CC4 stimulates dopamine release from striatal slices in vitro, and attenuates nicotine-induced self-administration and conditional place preference in vivo. Synonyms: CC4; CC 4; CC-4; Alternine; Ethylenedi-cytisine; (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2-[(1R,5S)-1,5,6,8-tetrahydro-8-oxo-1,5-methano-2H-pyrido[1,2-a][1,5]diazocin-3(4H)-yl]ethyl]-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one. Grade: ≥98% by HPLC. CAS No. 492-02-4. Molecular formula: C24H30N4O2. Mole weight: 406.52. |  |
| CC-401 | CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. The activation of JNK signaling is indentified in many immune-mediated kidney disease models. Thus, as the JNK inhibitor, CC-401 is found to be effective in these renal injury models. Synonyms: CC-401; CC 401; CC401. Grade: >98%. CAS No. 395104-30-0. Molecular formula: C22H24N6O. Mole weight: 388.47. | |
| CC 401 dihydrochloride | CC 401 dihydrochloride is a potent JNK inhibitor (Ki = 25-50 nM). CC 401 competitively binds to ATP-binding site of phosphorylated JNK to inhibit JNK. Uses: Hepatoprotective. Synonyms: CC-401 dihydrochloride; CC 401 dihydrochloride; CC401 dihydrochloride; 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride. Grade: ≥98% by HPLC. CAS No. 2250025-96-6. Molecular formula: C22H24N6O.2HCl. Mole weight: 461.39. | |
| CC-401 hydrochloride | ATP-competitive, selective JNK inhibitor. Decreases c-Jun transcription activity and proliferation. Decreases cytochrome c release and caspase 3 activation. Shows anti-ischemic, anti-inflammatory and antiapoptotic effects in vivo. Synonyms: CC 401 hydrochloride; CC401 hydrochloride; CC401 HCl. Grade: >98%. CAS No. 1438391-30-0. Molecular formula: C22H25ClN6O. Mole weight: 424.93. | |
| CC-618 | CC-618 has been found to be a PPARβ/δ antagonist that could be used to study the potential biological activity of Cys249 at some extent. IC50: 10 μM. Synonyms: 5-Thiazolecarboxamide, 4-methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-; 4-Methyl-2-[4-(trifluoromethyl)phenyl]-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-5-thiazolecarboxamide; CC 618; CC618; 4-Methyl-2-(4-(trifluoromethyl)phenyl)-N-(2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)ethyl)thiazole-5-carboxamide. Grade: 98%. CAS No. 1680204-90-3. Molecular formula: C20H15F6N3O3S2. Mole weight: 523.47. | |
| CC-671 | CC-671 is a novel dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) inhibitor with IC50s of 5 and 3 nM, which is used for the treatment of triple negative breast cancer initiated from a phenotypic screen. It is selective for Mps1/TTK and Clk2 over a panel of 255 kinases at 3 μM, but does inhibit DYRK3, DYRK1A, PHKG, DYRK1B, and Clk1 (IC50s = 99, 104, 136, 157, and 300 nM, respectively). Synonyms: CC671; CC 671. Grade: ≥95%. CAS No. 1618658-88-0. Molecular formula: C28H28N6O4. Mole weight: 512.6. | |
| CC-885 | CC-885 is a cereblon (CRBN) modulator with an anti-tumour activity mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 potently suppresses the proliferation of human acute myeloid leukaemia (AML) tumour cell lines. Uses: Antitumor agent. Synonyms: CC 885; CC885; N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea. Grade: 99%. CAS No. 1010100-07-8. Molecular formula: C22H21ClN4O4. Mole weight: 440.88. | |
| CC-90001 | CC-90001 is an orally available JNK inhibitor that is used in the research of Idiopathic pulmonary fibrosis (IPF) treatment. Synonyms: CC 90001; CC90001. Grade: 98% by HPLC. CAS No. 1403859-14-2. Molecular formula: C16H27N5O2. Mole weight: 321.42. | |
| CC-90002 | CC-90002 is a humanized anti-CD47 monoclonal antibody. CC-90002 binds to CD47 and inhibits CD47-SIRPα interaction. CC-90002 has been used in the research of acute myeloid leukemia. Synonyms: CC 90002; CC90002. CAS No. 2085844-54-6. | |
| CC-90003 | Extracellular-signal regulated kinases (ERKs) are a specific subtype of MAPK that have been extensively linked to regulation of synaptic plasticity and memory formation in many systems. CC-90003 is an irreversible and selective inhibitor of ERK1/2 with IC50s in the 10-20 nM range, which shows good kinase selectivity and antitumor activity in a 258-kinase biochemical assay. Synonyms: CC90003; CC 90003. Grade: ≥98%. CAS No. 1621999-82-3. Molecular formula: C22H21F3N6O2. Mole weight: 458.44. | |
| CC-90011 besylate | CC-90011 besylate is an orally active inhibitor of lysine specific demethylase-1 (LSD1). CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models. Uses: Antineoplastic agents. Synonyms: LSD1-IN-7 benzenesulfonate; Pulrodemstat besilate; CC-90011 benzenesulfonate. CAS No. 2097523-60-7. Molecular formula: C30H29F2N5O5S. Mole weight: 609.64. | |
| CC-99677 | CC-99677 is a novel, oral, and selective MK2 inhibitor with sustainable multi-cytokine inhibition for the treatment of ankylosing spondylitis and other inflammatory diseases. CC-99677 is extracted from patent WO2020236636, compound 1. CAS No. 1887069-10-4. Molecular formula: C22H20ClN5O3S. Mole weight: 469.94. | |
| CCB02 | CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity. Synonyms: CCB 02. Grade: 99%. CAS No. 2100864-57-9. Molecular formula: C14H9N3O. Mole weight: 235.24. | |
| CCCP | CCCP inhibits IFN-β production induced by various types of the STING pathway activators, and suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. Synonyms: CCCP; Mesoxalonitrile 3-chlorophenylhydrazone; 2-[(3-chlorophenyl)hydrazinylidene]propanedinitrile; Carbonyl Cyanide m Chlorophenyl Hydrazone; Carbonyl Cyanide m-Chlorophenyl; Hydrazone; Carbonyl Cyanide meta Chlorophenyl Hydrazone; Carbonyl Cyanide meta-Chlorophenyl Hydrazone; CCCP. CAS No. 555-60-2. Molecular formula: C9H5ClN4. Mole weight: 204.62. | |
| CCF0058981 | CCF0058981, a non-covalent SARS-CoV-2 3CLpro (SC2) inhibitor (IC50 = 68 nM), can inhibit SARS-CoV-1 3CLpro (SC1) with an IC50 of 19 nM. It has antiviral efficacy and has the potential to study COVID-19. Synonyms: CCF981; ML300-based SC inhibitor 41; N-(4-(1H-Imidazol-5-yl)phenyl)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-chlorobenzyl)acetamide. Grade: ≥98%. CAS No. 2708934-53-4. Molecular formula: C24H19ClN6O. Mole weight: 442.90. | |
| CCF-642 | CCF-642 is a protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib. Synonyms: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone; CCF-642; CCF 642; CCF642. CAS No. 346640-08-2. Molecular formula: C15H10N2O4S3. Mole weight: 378.44. | |
| CCG-100602 | CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. CCG-100602 specifically blocks the nuclear localization of MRTF-A, thereby inhibiting the fibrogenic transcription factor SRF. Synonyms: CCG-100602; 1207113-88-9; 1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; CHEMBL603141; compound 4g [PMID: 19963382]; 1-(3,5-bis(trifluoromethyl)benzoyl)-N-(4-chlorophenyl)piperidine-3-carboxamide; CCG100602; CCG 100602; GTPL6764; SCHEMBL1534209; BDBM50436237; AKOS040744973; MS-28902; HY-120855; CS-0079376; Q27075763; [3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide; 1-[3,5-bis (trifluoromethyl)benzoyl]-N-(4-chlorophenyl)-3-piperidinecarboxamide. Grade: 98%. CAS No. 1207113-88-9. Molecular formula: C21H17ClF6N2O2. Mole weight: 478.8. | |
| CCG-1423 | CCG-1423 is a potent inhibitor of RhoA/C-mediated gene transcription. It suppressed invasion of PC-3 prostate cancer cells in a matrigel model of metastasis. It induces intermediate mesoderm differentiation from ESCs. Synonyms: CCG 1423; N-[1-(4-chloroanilino)-1-oxopropan-2-yl]oxy-3,5-bis(trifluoromethyl)benzamide. Grade: >98%. CAS No. 285986-88-1. Molecular formula: C18H13ClF6N2O3. Mole weight: 454.75. | |
| CCG 203769 | CCG 203769 is a selective inhibitor of G protein signaling (RGS4). CCG 203769 blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM. Synonyms: RGS4 inhibitor 11b; 2-ethyl-4-butyl-1,2,4-thiadiazolidine-3,5-dione. Grade: 99%. CAS No. 410074-60-1. Molecular formula: C8H14N2O2S. Mole weight: 202.28. | |
| CCG 203971 | CCG 203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM). CCG 203971 inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway, and inhibits proliferation of SSc-derived dermal fibroblasts. It also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 μM). Synonyms: CCG-203971; CCG 203971; CCG203971. N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide. Grade: ≥98% by HPLC. CAS No. 1443437-74-8. Molecular formula: C23H21ClN2O3. Mole weight: 408.88. | |
| CCG 2046 | CCG 2046 is an inhibitor of regulator of G-protein signaling 4 (RGS4). It reduces the RGS4-Gαo protein-protein interaction signal. Synonyms: CCG 2046; CCG2046; CCG-2046; 3-Methyl-3-propyl-1,1,2,2-cyclopropanetetracarbonitrile; 1,1,2,2-tetracyano-3-methyl-3-propylcyclopropane. Grade: ≥99% by HPLC. CAS No. 13017-69-1. Molecular formula: C11H10N4. Mole weight: 198.22. | |
| CCG215022 | CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor (IC50s= 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively), with good selectivity against other closely related kinases such as GRK1 and PKA. Synonyms: 4-(4-fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; CCG215022; CCG 215022; CCG-215022. CAS No. 1813527-81-9. Molecular formula: C26H22FN7O3. Mole weight: 499.5. | |
| CCG-222740 | CCG-222740 is a potent and selective Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin (α-SMA) expression. Synonyms: CCG-222740; N-(4-chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide; N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide; C23H19ClF2N2O3; CHEMBL4105348; SCHEMBL17728947; BCP31985; XBD09869; s6673; AKOS037648832; AC-35745; BS-15759; HY-121750; CS-0083153; CCG 222740; CCG222740; D81359. CAS No. 1922098-69-8. Molecular formula: C23H19ClF2N2O3. Mole weight: 444.86. | |
| CCG-224406 | CCG-224406 is a highly selective and potent inhibitor of G Protein-Coupled Receptor Kinase 2 (IC50= 130 nM), with 700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1. Synonyms: CCG 224406; CCG224406; N-(1H-Indazole-5-yl)-2-oxo-4-[3-(2,6-dimethoxybenzylcarbamoyl)-4-fluorophenyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide. Grade: >98%. CAS No. 1870843-22-3. Molecular formula: C29H27FN6O5. Mole weight: 558.57. | |
| CCG 232601 | CCG 232601 is a selective and orally bioactive inhibitor of the Rho/MRTF/SRF signaling pathway (IC50 value of 0.55 μM (SRE.L assay)) as a potential antifibrotic therapeutic for systemic scleroderma. CCG-232601 inhibits the development of bleomycin-induced dermal fibrosis in mice when administered orally. Synonyms: N-(4-chlorophenyl)-5,5-difluoro-1-(3-pyridin-4-ylbenzoyl)piperidine-3-carboxamide; CCG-232601; CCG 232601; CCG232601. Grade: 99%. CAS No. 1922099-21-5. Molecular formula: C24H20ClF2N3O2. Mole weight: 455.88. | |
| CCG 50014 | CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM, exhibiting >20-fold selectivity over other RGS proteins. Synonyms: CCG50014; CCG-50014; 4-(4-fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione. Grade: >98%. CAS No. 883050-24-6. Molecular formula: C16H13FN2O2S. Mole weight: 316.35. | |
| CCG-63802 | CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein. It is selective amongst RGS proteins, with greatest potency at RGS4. It also inhibits GTPase accelerating protein activity of RGS4, blocks its interaction with Gαo, and retains activity under reducing conditions. Synonyms: CCG-4986; CCG 4986; CCG4986. Grade: >98%. CAS No. 620112-78-9. Molecular formula: C26H18N4O2S. Mole weight: 450.51. | |
| CCG-63808 | CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. Synonyms: CCG-63808; CCG 63808; CCG63808. Grade: >98%. CAS No. 620113-73-7. Molecular formula: C25H15FN4O2S. Mole weight: 454.48. | |
| CCK (26-30) (sulfated) | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (26-30) is an N-terminal fragment of CCK, the sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% at 0.1 mM. Synonyms: N-Acetyl cholecystokinin (26-30) (sulfated). Grade: ≥95%. CAS No. 89911-69-3. Molecular formula: C33H41N7O12S2. Mole weight: 791.85. | |
| CCK (26-31) (sulfated) | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (26-31) is an N-terminal fragment of CCK, the sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% at 0.1 mM. Synonyms: N-Acetyl cholecystokinin (26-31) (sulfated). Grade: ≥95%. CAS No. 89911-65-9. Molecular formula: C38H50N8O13S3. Mole weight: 923.05. | |
| CCK (27-33) (non-sulfated) | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK (27-33) is a C-terminal fragment of CCK. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes with IC50 of 4 μM and inhibits electrically-stimulated contraction of isolated guinea pig ileum with IC50 of 17 μM. Synonyms: Cholecystokinin (27-33) (non-sulfated). Grade: ≥95%. CAS No. 47910-79-2. Molecular formula: C45H57N9O10S2. Mole weight: 948.12. | |
| CCK-A receptor inhibitor 1 | CCK-A receptor inhibitor 1 is an inhibitor of cholecystokinin A (CCK-A) receptor with a binging IC50 of 340 nM. Synonyms: Pentanoic acid, 5-[(3-methoxypropyl)pentylamino]-4-[(2-naphthalenylsulfonyl)methyl]-5-oxo-; 5-[(3-Methoxypropyl)(pentyl)amino]-4-[(2-naphthylsulfonyl)methyl]-5-oxopentanoic acid. Grade: ≥95%. CAS No. 137004-80-9. Molecular formula: C25H35NO6S. Mole weight: 477.61. | |
| CCK-B Receptor Antagonist 1 | CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor antagonist with the potential to reduce gastric acid secretion. Synonyms: Urea, N-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]-; 1-[1-(3,3-Dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea. Grade: ≥99%. CAS No. 168161-71-5. Molecular formula: C28H30N6O3. Mole weight: 498.58. | |
| CCK-B Receptor Antagonist 2 | CCK-B Receptor Antagonist 2, a potent and orally active Gastrin/CCK-B antagonist (IC50 = 0.43 nM), also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM. Synonyms: (R)-1-(3-Aminophenyl)-3-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea; 1-(3-Amino-phenyl)-3-[(R)-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-urea; 1-(3-Aminophenyl)-3-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea. Grade: ≥98%. CAS No. 155412-88-7. Molecular formula: C27H28N6O3. Mole weight: 484.55. | |
| CCK Octapeptide, non-sulfated acetate | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK Octapeptide (non-sulfated) is the non-sulfated form of the C-terminal octapeptide of CCK. Synonyms: CCK-8 (desulfated) acetate; Cholecystokinin (CCK) (26-33) acetate. Molecular formula: C51H66N10O15S2. Mole weight: 1123.26. | |
| CCMI | CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). It was shown to induce positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). CCMI enhances cognition in rodent models. Synonyms: AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide; (Z)-3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide. CAS No. 917837-54-8. Molecular formula: C19H15Cl2N3O2. Mole weight: 388.25. | |
| cCMP | cCMP, an intriguing cyclic cytidine monophosphate compound extensively utilized in the realm of biomedical research, has emerged as an invaluable protagonist. Affiliated with the intricacies of various signaling pathways, it conveniently serves as a second messenger, facilitating a comprehensive comprehension of cCMP's involvement in pivotal cellular functions. In the realm of immunology, its versatile nature enables it to diligently modulate the immune response, thus exhibiting promising potential in the battle against inflammatory diseases and cancerous afflictions. Synonyms: Cytidine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 54925-33-6. Molecular formula: C9H11N3O7P · Na. Mole weight: 327.2. | |
| cCMP-AM | cCMP-AM is a membrane-permeant and metabolically activatable prodrug of cCMP, the potential further second messenger. cCMP is released after permeation and metabolism of cCMP-AM by esterases, which is trapped inside the cell and metabolized to result in a pulse-type signal. Synonyms: Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 95% by HPLC. Molecular formula: C12H16N3O9P. Mole weight: 377.2. | |
| CCMQ | CCMQ is an inhibitor of homoquinolinic acid binding to non-NMDA sensitive sites. It is combined with [3H]-homoquinolinic acid to characterize NR2B-containing NMDA receptors. Synonyms: 2-Carboxy-3-carboxymethylquinoline. CAS No. 132623-44-0. Molecular formula: C12H9NO4. Mole weight: 231.21. | |
| CCP peptide TFA | CCP peptide TFA is a synthetic cyclic citrullinated peptide that can be used as the substrate for detecting anti-CCP antibodies serologically. Synonyms: His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16). Grade: 95%. Molecular formula: C89H146N41F3O34S2. Mole weight: 2455.49. | |
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-; 2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grade: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. | |
| CCR1 antagonist 6 | CCR1 antagonist 6 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 3 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. CAS No. 2436773-01-0. Molecular formula: C21H23ClN4O3S. Mole weight: 446.95. | |
| CCR1 antagonist 7 | CCR1 antagonist 7 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 4 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[2-[(methylamino)sulfonyl]-4-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[2-(methylsulfamoyl)-4-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. Grade: 98%. CAS No. 2446154-74-9. Molecular formula: C21H24ClN5O3S. Mole weight: 461.96. | |
| CCR1 antagonist 9 | CCR1 antagonist 9 is a potent and selective antagonist of CCR1 with an IC50? of? 6.8 nM in calcium flux assay. Synonyms: 1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide; CCR1 inhibitor 19e; 1H-Pyrazolo[3,4-c]pyridine-4-carboxamide, 1-(4-fluorophenyl)-N-[[2-(methylsulfonyl)-4-pyridinyl]methyl]-; 1-(4-Fluorophenyl)-N-{[2-(methylsulfonyl)-4-pyridinyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide. Grade: ≥95%. CAS No. 1220026-26-5. Molecular formula: C20H16FN5O3S. Mole weight: 425.44. | |
| CCR2 antagonist 1 | CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM. Synonyms: [(1S,3R)-3-{[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino}-1-isopropylcyclopentyl][7-(trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinyl]methanone; Methanone, [(1S,3R)-3-[[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-(1-methylethyl)cyclopentyl][3,4-dihydro-7-(trifluoromethyl)-2(1H)-isoquinolinyl]-; (1R)-5-bromo-N-[(1R,3S)-3-(propan-2-yl)-3-[7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]cyclopentyl]-2,3-dihydro-1H-inden-1-amine. Grade: ≥98%. CAS No. 1683534-96-4. Molecular formula: C28H32BrF3N2O. Mole weight: 549.47. | |
| CCR2 antagonist 3 | CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. Synonyms: AZD2927; AZD-2927; (S)-4-Fluoro-N-(1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide; 4-Fluoro-N-[(2S)-1-(3-hydroxy-1-azetidinyl)-3-methyl-2-butanyl]-N,3-dimethylbenzamide. Grade: ≥98%. CAS No. 1380100-86-6. Molecular formula: C17H25FN2O2. Mole weight: 308.39. | |
| CCR2-RA | CCR2-RA is a novel C-C chemokine receptor type 2 (CCR2) antagonist. Synonyms: 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-. Grade: 95%. CAS No. 512177-31-0. Molecular formula: C18H19ClFNO3. Mole weight: 351.8. | |
| CCR3 antagonist 1 | A potent antagonist of CCR3 (IC50= 1.8 nM). Synonyms: CCR3 antagonist 1; CCR 3 antagonist 1; CCR-3 antagonist 1; 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]-2-oxoethyl]thio]-. CAS No. 879399-82-3. Molecular formula: C19H21Cl2N3O4S2. Mole weight: 490.42. | |
| CCR4 Antagonist | A potent CCR4 antagonist. Synonyms: C 021 dihydrochloride; C021 dihydrochloride; C-021 dihydrochloride; 2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine; C-021; CCR4 Antagonist; CHEMBL508207; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolina. CAS No. 864289-85-0. Molecular formula: C27H41N5O2. Mole weight: 467.6. | |
| CCR4 antagonist 2 | CCR4 antagonist 2 is a potent and orally bioavailable small molecule CCR4 antagonist, with IC50s of 40 and 70 nM for Ca2+ flux and (chemotaxis) CTX, respectively. It inhibits Treg trafficking into the tumor microenvironment without suppressing the number of Treg in healthy tissue. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl]-; 1-[(1R)-1-(2,4-Dichlorophenyl)ethyl]-6-{(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl}-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile. Grade: ≥97%. CAS No. 2206788-99-8. Molecular formula: C26H28Cl2N6O. Mole weight: 511.45. | |
| CCR4 antagonist 3 | CCR4 antagonist 3, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-. CAS No. 2174938-70-4. Molecular formula: C24H27Cl2N7O. Mole weight: 500.42. | |
| CCR4 antagonist 3 hydrochloride | CCR4 antagonist 3 hydrochloride, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-, hydrochloride (1:x). Grade: ≥98%. CAS No. 2174938-71-5. Molecular formula: C24H27Cl2N7O.xHCl. Mole weight: 500.42 (free base). | |
| CCR5 antagonist 1 | CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication. Synonyms: AC-31371; HY-100261. Grade: >98%. CAS No. 716354-86-8. Molecular formula: C39H46ClF2N5O3S. Mole weight: 738.3. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50 >30000 nM), and CCR7 (IC50 = 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation and is used in the study of autoimmune diseases and cancer. Synonyms: 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-; 4-{4-[(trans-4-{[5-(Trifluoromethyl)-2-pyridinyl]amino}cyclohexyl)sulfonyl]phenyl}-2-pyridinecarboxamide. Grade: ≥98%. CAS No. 2437547-04-9. Molecular formula: C24H23F3N4O3S. Mole weight: 504.52. | |
| CCR7 Ligand 1 | CCR7 Ligand 1 is an allosteric Ligand and human CC chemokine receptor 7 (CCR7) antagonist with a Kd of 3 nM. It is a thiadiazole-dioxide ligand that suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. Synonyms: CCR7-Cmp2105; Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N,6-trimethyl-; 3-[(4-{[(1R)-2,2-Dimethyl-1-(5-methyl-2-furyl)propyl]amino}-1,1-dioxido-1,2,5-thiadiazol-3-yl)amino]-2-hydroxy-N,N,6-trimethylbenzamide. Grade: ≥98%. CAS No. 681514-83-0. Molecular formula: C22H29N5O5S. Mole weight: 475.56. | |
| CCT007093 | CCT007093 is a potent PPM1D inhibitor or WIP1 inhibitor that selectively reduces viability of human tumour cell lines. Synonyms: CCT007093; CCT-007093; CCT 007093. Grade: 0.98. CAS No. 176957-55-4. Molecular formula: C15H12OS2. Mole weight: 272.38. | |
| CCT018159 | CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human Hsp90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis. Synonyms: CCT-018159; CCT 018159. Grade: >98%. CAS No. 171009-07-7. Molecular formula: C20H20N2O4. Mole weight: 352.39. | |
| CCT020312 | CCT020312 is a potent and selective EIF2AK3 activator. Synonyms: HY-119240. CAS No. 324759-76-4. Molecular formula: C31H30Br2N4O2. Mole weight: 650.40. | |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytosolic β-catenin levels in mouse L-cells. Synonyms: SR 01000418274; CCT 031374 hydrobromide; SR01000418274; CCT031374 hydrobromide; SR-01000418274; CCT-031374 hydrobromide; 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide. Grade: ≥98% by HPLC. CAS No. 1219184-91-4. Molecular formula: C23H19N3O.HBr. Mole weight: 434.33. | |
| CCT128930 | CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. Synonyms: CCT128930; CCT-128930; CCT 128930. CAS No. 885499-61-6. Molecular formula: C18H20ClN5. Mole weight: 341.8379. | |
| CCT128930 hydrochloride | CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50 = 6 nM). CCT128930 hydrochloride also induces cell cycle arrest, DNA damage, and autophagy. Synonyms: 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine hydrochloride. Grade: 98%. CAS No. 2453324-32-6. Molecular formula: C18H21Cl2N5. Mole weight: 378.30. | |
| CCT129202 | CCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1- and ABCG2-mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem-like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further clinical investigation. Synonyms: CCT129202; CCT-129202; CCT 129202. CAS No. 942947-93-5. Molecular formula: C23H25ClN8OS. Mole weight: 497.02. | |
| CCT-137690 | CCT137690, an aurora kinase inhibitor CCT137690, is a highly selective, orally bioavailable imidazo[4,5-b]pyridine derivative that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays and exhibits anti-proliferative activity against a wide range of human solid tumour cell lines. CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates, respectively) in HCT116 and HeLa cells. Continuous exposure of tumour cells to the inhibitor causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis. This is accompanied by p53/p21/BAX induction, thymidine kinase 1 (TK1) downregulation and PARP cleavage. Furthermore, CCT137690 treatment of MYCN-amplified neuroblastoma cell lines inhibits cell proliferation and decreases MYCN protein expression. Importantly, in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation, this compound significantly inhibits tumour growth. The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN amplified neuroblastoma. Synonyms: CCT-137690. CCT 137690. CCT137690. CAS No. 1095382-05-0. Molecular formula: C26H31BrN8O. Mole weight: 551.48. | |
| CCT196969 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT196969 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT196969; CCT-196969; CCT 196969. N-[4-[(3,4-Dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]urea. Grade: 98%. CAS No. 1163719-56-9. Molecular formula: C27H24FN7O3. Mole weight: 513.52. | |
| CCT241161 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT 241161 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT241161; CCT-241161; CCT 241161. 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea. Grade: 98%. CAS No. 1163719-91-2. Molecular formula: C28H27N7O3S. Mole weight: 541.62. | |
| CCT 241533 dihydrochloride | CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM) displaying >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells, and blocks ionizing radiation-induced apoptosis of mouse thymocytes. Synonyms: CCT 241533 dihydrochloride; CCT241533 dihydrochloride; CCT-241533 dihydrochloride; (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1962925-28-5. Molecular formula: C23H27FN4O4.2HCl. Mole weight: 515.41. | |
| CCT241736 | CCT241736 is a potent and orally active and dual FLT3-Aurora inhibitor, which has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively. It also inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 with 0.1 μM in cellular assay. Synonyms: CCT-241736; CCT 241736. Grade: ≥98%. CAS No. 1402709-93-6. Molecular formula: C22H23Cl2N7. Mole weight: 456.37. | |
| CCT244747 | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grade: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46. | |
| CCT245737 | CCT245737 is an orally bioactive CHK1 inhibitor (IC50 of 1.4 nM), displaying >1,000-fold selectivity against CHK2 and CDK1. It potently inhibits cellular CHK1 activity (IC50 30-220nM) and enhances gemcitabine and SN38 cytotoxicity in multiple human tumor cell lines and human tumor xenograft models. It causes inhibition of tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia. Synonyms: CCT-245737; CCT 245737; CCT245737; 5-[(4-{[(2R)-morpholin-2-ylmethyl]amino}-5-(trifluoromethyl)pyridin-2-yl)amino]pyrazine-2-carbonitrile. CAS No. 1489389-18-5. Molecular formula: C16H16F3N7O. Mole weight: 379.347. | |
| CCT245737(S) | CCT245737, a nitrogen heterocycle compound, has been found to be a CHK1 inhibitor that could probable be effective in antineoplastic studies. It is still under Phase I trail for Solid tumours. IC50: 30-220 nM. Synonyms: CCT245737; CCT 245737; CCT-245737; GTPL9187; GTPL 9187; GTPL-9187; 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile. Grade: 98%. CAS No. 1489389-23-2. Molecular formula: C16H16F3N7O. Mole weight: 379.14. | |
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