BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Carvedilol EP Impurity B | An impurity from the process of Carvedilol, which is a medication used to treat high blood pressure, congestive heart failure (CHF), and left ventricular dysfunction in otherwise stable people. Synonyms: Carvedilol Bis-carbazole; USP Carvedilol Related Compound B; 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). Grade: > 95%. CAS No. 918903-20-5. Molecular formula: C39H39N3O6. Mole weight: 645.76. |  |
| Carvedilol EP impurity E | Carvedilol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well. Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). Carvedilol EP impurity E is an impurity of Carvedilol. Synonyms: Carvedilol Impurity E; Carvedilol USP E. Grade: ≥95%. CAS No. 64464-07-9. Molecular formula: C9H14ClNO2. Mole weight: 203.67. | |
| Carvedilol glucuronide | Carvedilol glucuronide is a metabolite of carvedilol, which is a non-selective β-adrenergic receptor antagonist and α1-adrenergic receptor antagonist used primarily for the treatment of hypertension, heart failure, and certain types of arrhythmias. Synonyms: (R,S)-Carvedilol O-β-D-glucuronide; 2-(9H-Carbazol-4-yloxy)-1-[[[2-(2-methoxyphenoxy)ethyl]amino]methyl]ethyl β-D-Glucopyranosiduronic Acid; Carvedilol β-D-β-D-glucuronide; Carvedilol 2-D-Glucuronide; (2S,3S,4S,5R,6R)-6-((1-((9H-Carbazol-4-yl)oxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Grade: ≥95%. CAS No. 114869-83-9. Molecular formula: C30H34N2O10. Mole weight: 582.61. | |
| Carvedilol Impurity 2 | 2-(9H-Carbazol-4-yloxy)-ethenol is an impurity of Carvedilol , a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure. Synonyms: 2-(9H-Carbazol-4-yloxy)-ethenol. Grade: > 95%. CAS No. 1801551-41-6. Molecular formula: C14H11NO2. Mole weight: 225.25. | |
| Carvedilol Impurity A | An impurity from the process of Carvedilol. Carvedilol impurity A. Synonyms: 1-[[4-(2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amino]propyl]-9H-carbazol-4-yl]oxy]-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol; 1-(9H-Carbazol-4-yloxy)-3-[[2-hydroxy-3-[[2-(2-methoxyphenoxy)ethyl]amino]propyl][2-(2-methoxyphenoxy)ethyl]amino]-2-propanol. Grade: > 95%. CAS No. 1076199-79-5. Molecular formula: C36H43N3O7. Mole weight: 629.76. | |
| Carvedilol Impurity C | Carvedilol impurity. A new degradation product in Carvedilol tablets. Synonyms: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl](phenylmethyl)amino]-2-propanol. Grade: > 95%. CAS No. 72955-94-3. Molecular formula: C31H32N2O4. Mole weight: 496.61. | |
| Carvedilol Impurity D | An impurity of Carvedilol. Synonyms: (9H-Carbazol-4-yloxy)-3-[4-[2-hydroxy-3-[[2-(2-methoxyphenoxy)ethyl]amino]propoxy]-9H-carbazol-9-yl]propan-2-ol; Carvedilol Impurity D; α-[(9H-Carbazol-4-yloxy)methyl]-4-[2-hydroxy-3-[[2-(2-methoxyphenoxy)ethyl]amino]propoxy]-9H-carbazole-9-ethanol. Grade: > 95%. CAS No. 1391052-16-6. Molecular formula: C39H39N3O6. Mole weight: 645.76. | |
| Carvedilol Phosphate | Carvedilol phosphate hemihydrate is a nonselective beta (β1, β2) blocker and alpha (α1) blocker, inhibits LDL oxidation (IC50 = 3.8 μM). Uses: Nonselective beta (β1, β2) blocker and alpha (α1) blocker. Synonyms: 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; phosphoric acid; hydrate. Grade: ≥98%. CAS No. 610309-89-2. Molecular formula: C24H26N2O4·H2O·H3O4P. Mole weight: 522.488. | |
| Carvedilol Related Compound F | Carvedilol derivative. Synonyms: 1-[[2-(2-Methoxyphenoxy)ethyl]amino]-3-[(2,3,4,9-tetrahydro-1H-carbazol-5-yl)oxy]-2-propanol. Grade: > 95%. CAS No. 1246820-73-4. Molecular formula: C24H30N2O4. Mole weight: 410.52. | |
| Cas9-IN-3 | Cas9-IN-3 is a potent inhibitor of Cas9 with an IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in various species. Synonyms: 3-Biphenylyl(4-methyl-1-piperidinyl)methanone; Methanone, [1,1'-biphenyl]-3-yl(4-methyl-1-piperidinyl)-. CAS No. 2322051-02-3. Molecular formula: C19H21NO. Mole weight: 279.38. | |
| Casein Kinase II Inhibitor IV Hydrochloride | Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation. Synonyms: 3-(3-{2-[(3,4,5-Trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}phenyl)propanenitrile hydrochloride (1:1); Benzenepropanenitrile, 3-[2-[(3,4,5-trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, hydrochloride (1:1). Grade: ≥98%. Molecular formula: C24H24ClN5O3. Mole weight: 465.93. | |
| Casein Kinase inhibitor A51 | Casein Kinase inhibitor A51 is a novel pan-specific CKI (CSNK1) inhibitor (Kd=0.5-20 nM, CKIα Kd=5.3 nM). Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Synonyms: BTX-A51; CKIα inhibitor A51. Grade: 98%. CAS No. 2079068-74-7. Molecular formula: C18H25ClN6. Mole weight: 360.88. | |
| Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 is a novel pan-specific CKI (CSNK1) inhibitor (Kd=1-10 nM, CKIα Kd=9.8 nM). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Synonyms: CKIα inhibitor A86. Grade: 98%. CAS No. 2079069-01-3. Molecular formula: C18H25FN6. Mole weight: 344.44. | |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Synonyms: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol. Grade: >98%. CAS No. 425399-05-9. Molecular formula: C20H22N2O. Mole weight: 306.41. | |
| Casopitant | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. Uses: Antiemetics. Synonyms: GW679769; GW 679769; GW-679769; Zunrisa; Rezonic; 4-(4-Acetylpiperazin-1-yl)-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide. CAS No. 414910-27-3. Molecular formula: C30H35F7N4O2. Mole weight: 616.62. | |
| Casopitant Mesylate | Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide; methanesulfonic acid. Grade: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72. | |
| CASP3 Activator 1541 | CASP3 Activator 1541 is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Synonyms: 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide; Procaspase-3 activator 1541. Grade: 95%. CAS No. 1100353-03-4. Molecular formula: C24H17N3O4. Mole weight: 411.41. | |
| Caspase-3/7 Inhibitor I | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grade: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
| Caspofungin Acetate C0 Analog | Caspofungin Acetate C0 Analog is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C56H95N10O19. Mole weight: 1212.41. | |
| Caspofungin Impurity 1 | Caspofungin Impurity 1 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity 10 | Caspofungin Impurity 10 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C53H90N10O15. Mole weight: 1107.34. | |
| Caspofungin Impurity 11 | Caspofungin Impurity 11 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C102H168N18O30. Mole weight: 2126.52. | |
| Caspofungin Impurity 13 | Caspofungin Impurity 13 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Synonyms: (3S)-(4R)-1-(10,12-Dimethyl-1-oxotetradecyl)-4,5-dihydroxy-D-prolyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-(3R)-3-hydroxy-L-ornithyl-3-hydroxy-L-prolinamide; 5-Des(2-aminoethylamino)-5-hydroxy-4,5-seco-5,9-cyclo Caspofungin. CAS No. 314080-31-4. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity 14 | Caspofungin Impurity 14 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity 15 | Caspofungin Impurity 15 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C57H86N8O16S. Mole weight: 1171.40. | |
| Caspofungin Impurity 16 | Caspofungin Impurity 16 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C57H88N8O15S. Mole weight: 1157.41. | |
| Caspofungin Impurity 17 | Caspofungin Impurity 17 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H88N10O14. Mole weight: 1077.31. | |
| Caspofungin Impurity 18 Acetate | Caspofungin Impurity 18 Acetate is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H86N8O18. Mole weight: 1111.28. | |
| Caspofungin Impurity 19 | Caspofungin Impurity 19 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity 22 | Caspofungin Impurity 22 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C49H78N8O17. Mole weight: 1051.18. | |
| Caspofungin Impurity 23 | Caspofungin Impurity 23 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C50H80N8O16. Mole weight: 1049.21. | |
| Caspofungin Impurity 24 | Caspofungin Impurity 24 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C50H80N8O16. Mole weight: 1049.21. | |
| Caspofungin Impurity 25 | Caspofungin Impurity 25 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C62H104N8O19S. Mole weight: 1297.59. | |
| Caspofungin Impurity 26 | Caspofungin Impurity 26 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C51H86N10O15. Mole weight: 1079.28. | |
| Caspofungin Impurity 3 | Caspofungin Impurity 3 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C56H84N8O16S. Mole weight: 1157.37. | |
| Caspofungin Impurity 4 | Caspofungin Impurity 4 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C56H86N8O15S. Mole weight: 1143.39. | |
| Caspofungin Impurity 6 Diacetate | Caspofungin Impurity 6 Diacetate is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C56H96N10O20. Mole weight: 1229.41. | |
| Caspofungin Impurity 7 Diacetate | Caspofungin Impurity 7 Diacetate is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C56H94N10O20. Mole weight: 1227.40. | |
| Caspofungin Impurity 8 | Caspofungin Impurity 8 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H90N10O14. Mole weight: 1079.33. | |
| Caspofungin Impurity 9 | Caspofungin Impurity 9 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity A | Caspofungin Impurity A, is a metabolite of Caspofungin, which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall, and thus used as an antifungal drug. Synonyms: (3S)-(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithyl-L-seryl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-(3R)-3-hydroxy-L-ornithyl-3-hydroxy-L-proline; EX-A3042. Grade: 90%. CAS No. 1202167-57-4. Molecular formula: C51H86N10O15. Mole weight: 1097.31. | |
| Caspofungin Impurity A Acetate Salt | Caspofungin Impurity A Acetate Salt is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C51H86N10O15.xC2H4O2. Mole weight: 1079.28 (free base). | |
| Caspofungin Impurity B | Caspofungin Impurity B is the primary degradation product of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity C | Caspofungin Impurity C is a degradation product of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. CAS No. 251095-73-5. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity D | Caspofungin Impurity D is an impurity of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity Dimer 2 | Caspofungin Impurity Dimer 2 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Molecular formula: C102H166N18O29. Mole weight: 2108.51. | |
| Caspofungin Impurity E | Caspofungin Impurity E is an impurity of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity F | Caspofungin Impurity Dimer 1 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Synonyms: (4R)-N-((2S,3S,4S)-1-(((2S)-5-Amino-1-((3S,4S)-3-carbamoyl-4-hydroxypyrrolidin-1-yl)-3-hydroxy-1-oxopentan-2-yl)amino)-3,4-dihydroxy-4-(4-hydroxyphenyl)-1-oxobutan-2-yl)-1-((2S)-2-((2R,4S)-5-((2-(((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-((10R,12S)-10,12-dimethyltetradecanamido)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-yl)amino)ethyl)amino)-2-((10R,12S)-10,12-dimethyltetradecanamido)-4-hydroxypentanamido)-3-hydroxybutanoyl)-4-hydroxypyrrolidine-2-carboxamide. Molecular formula: C102H168N18O30. Mole weight: 2126.52. | |
| CaSR antagonist 18c | A calcium-sensing receptor (CaSR) antagonist (IC50 = 76 nM) potentially used as an anabolic agent for the treatment of osteoporosis. Uses: Potential anabolic agent for osteoporosis. Grade: 99%. CAS No. 802916-30-9. Molecular formula: C32H35N3O6. Mole weight: 557.64. | |
| Casuarine-6-O-a-D-glucoside | Casuarine-6-O-a-D-glucoside is a naturally occurring compound derived from Casuarina trees, holding immense potential in the biomedical industry, specifically development. Extensive studies have revealed its profound efficacy in studying an array of afflictions, including cancer and inflammation. Molecular formula: C14H25NO10. Mole weight: 367.35. | |
| Catechol a-D-glucopyranoside | Catechol a-D-glucopyranoside is an extensively researched compound predominantly employed , exhibiting remarkable prospects for potential researchs targeting neurodegenerative conditions as well as specific malignancies. Molecular formula: C12H16O7. Mole weight: 272.25. | |
| Catestatin acetate | Catestatin, a peptide compound, has been found to be a non-competitive nicotinic cholinergic antagonist. Synonyms: Chromogranin A344-364 acetate. Molecular formula: C109H177N37O28S. Mole weight: 2485.87. | |
| Catestatin TFA | Catestatin TFA is a 21-amino acid residue, cationic and hydrophobic peptide that regulates cardiac function and blood pressure. Catestatin TFA is also a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release. Grade: 99%. Molecular formula: C109H174F3N37O28S. Mole weight: 2539.84. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grade: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Cathepsin Inhibitor 1 | Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. The IC50s for Cathepsin L, L2, S, K, B are 7.9, 6.7, 6.0, 5.5 and 5.2 nM, respectively. Synonyms: Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Grade: ≥98%. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. | |
| Cathepsin S inhibitor | Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Synonyms: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. Grade: >98%. CAS No. 1373215-15-6. Molecular formula: C25H29FN4O5. Mole weight: 484.52. | |
| Cationic starch | Cationic starch is a biopolymer used in as a delivery system for development of drugs or gene therapy. Its positively charged structure allows efficient binding to negatively charged molecules aiding in targeted drug delivery and enhanced gene transfection. Synonyms: (3-Chloro-2-hydroxypropyl)trimethylammonium chloride modified starch; Starch, (2-hydroxypropyl)trimethylammonium chloride ether; Starch, 2-hydroxy-3-trimethylammoniopropylether, chloride; Starch, 2-hydroxy-3-(trimethylammonio)propyl ether, chloride; 2-Hydroxy-3-(trimethylammonio)propyl starch chloride; 2-Hydroxy-3-(trimethylammonio)propyl starch ether chloride; Sensomer CI 50; Starch 3-(trimethylammonio)-2-hydroxypropyl ether chloride salt; Starch 3-ether with (2,3-dihydroxypropyl)trimethylammonium chloride; Starch ether with (2,3-dihydroxypropyl)trimethylammonium chloride; Starch ether with 2,3-epoxypropyltrimethylammonium chloride; Starch ether with glycidylt rimethylammonium chloride; Starch hydroxypropyltrimonium chloride; Topcat L 95; YZC 2; YZG 2. Grade: ≥95%. CAS No. 56780-58-6. | |
| CATPB | CATPB is a human FFA2 inverse agonist (pKi = 7.87). It increases forskolin-induced cAMP production, and inhibits acetate-induced MAPK signaling in cells expressing human FFA2. Synonyms: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid. Grade: ≥98% by HPLC. CAS No. 1322598-09-3. Molecular formula: C19H17ClF3NO3. Mole weight: 399.79. | |
| Cav 2.2 blocker 1 | Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2) blocker for the treatment of pain. Synonyms: compound 9. CAS No. 1567335-29-8. Molecular formula: C25H29ClN2O2. Mole weight: 424.96. | |
| CAY10397 | Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). CAY10397 is a selective inhibitor of 15-hydroxy PGDH, significantly suppressing endogenous 11-oxo-ETE production with a corresponding increase in 11(R)-HETE. It is a selective inhibitor of 15-hydroxy PGDH with IC50 of 10 μM. Synonyms: CK47A. Grade: ≥98%. CAS No. 78028-01-0. Molecular formula: C17H16N2O5. Mole weight: 328.3. | |
| CAY10398 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. It has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing. Synonyms: MD 85; PX 089274. Grade: ≥98%. CAS No. 193551-00-7. Molecular formula: C15H23N3O3. Mole weight: 293.4. | |
| CAY10401 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. It is approximately 580-fold more potent than oleyl trifluoromethyl ketone. Synonyms: CAY 10401; CAY-10401; 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one. Grade: ≥98%. CAS No. 288862-89-5. Molecular formula: C24H34N2O2. Mole weight: 382.5. | |
| CAY10404 | CAY10404 is a potent, selective COX-2 inhibitor. Synonyms: CAY 10404; CAY-10404; CAY10404; 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole. CAS No. 340267-36-9. Molecular formula: C17H12F3NO3S. Mole weight: 367.4. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grade: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| CAY10412 | Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells with IC50 of 3 μM. It could be a useful tool for distinguishing the competing transporter theories. CAY10412 may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations. Synonyms: CAY 10412; CAY-10412. Grade: ≥98%. CAS No. 390824-17-6. Molecular formula: C25H36O2S. Mole weight: 400.6. | |
| CAY10416 | CAY10416 is a dual COX-2/5-LO inhibitor. Synonyms: CHEMBL423638; CAY10416; CHEMBL 423638; CAY 10416; CHEMBL-423638; CAY-10416; ; 43919-96-8; 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole; 3-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-(4-(methylsulfonyl)phenyl)-5-phenyl-1H-pyraz. CAS No. 443919-96-8. Molecular formula: C29H29FN2O5S. Mole weight: 536.6. | |
| CAY10429-d3 | Abnormal Cannabidiol is a potent and selective GPR55 agonist. It is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects. CAY10429-d3 contains three deuterium atoms at the terminal methyl position. Synonyms: Abn-CBD-d3; Abnormal cannabidiol-d3. Grade: ≥99% atom D. Molecular formula: C21H27D3O2. Mole weight: 317.5. | |
| CAY10434 | 20-HETE is an important metabolite of arachidonic acid in the vasculature, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10434 is a selective inhibitor of the 20-HETE synthase CYP4A11 displaying an IC50 value of 8.8 nM when tested in human renal microsomes. It is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes. Synonyms: CAY 10434; CAY-10434. Grade: ≥98%. CAS No. 769917-29-5. Molecular formula: C17H25N3O. Mole weight: 287.4. | |
| CAY10435 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH with Ki value of 0.57 nM. It exhibited IC50 values of 0.81 nM, 83 nM, and 50 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Synonyms: CAY 10435; CAY-10435. Grade: ≥98%. CAS No. 288862-73-7. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| CAY10443 | Mitochondrial release of cytochrome c triggers apoptosis including caspase-9, which is called the apoptosome. Apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs. CAY10443 is an apoptotic activators and activated caspase-3 with an EC50 of 5 μM. Synonyms: (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate. Grade: ≥98%. CAS No. 582314-48-5. Molecular formula: C17H15Cl2NO2. Mole weight: 336.2. | |
Our database is helping our users find suppliers everyday.
