BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Calcium 2-glycerophosphate | Calcium 2-glycerophosphate is an impurity of Glycerol, which is widely used in the food industry as a sweetener and humectant in pharmaceutical formulations. Synonyms: 1,2,3-Propanetriol, 2-(dihydrogen phosphate), calcium salt (1:1); 1,3-Dihydroxypropan-2-yl dihydrogen phosphate calcium salt; Calcium beta-glycerophosphate; Calcium 1,3-hydroxypropyl phosphate; beta-glycerophosphoric acid calcium salt; 1,3-Dihydroxypropan-2-yl dihydrogen phosphate calcium salt. Grade: ≥95%. CAS No. 58409-70-4. Molecular formula: C3H7CaO6P. Mole weight: 210.13. |  |
| Calcium Ascorbate Dihydrate | Calcium Ascorbate Dihydrate is a salt of Ascorbic Acid, physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndromes such as scurvy. Used as antimicrobial and antioxidant in foodstuffs. Synonyms: L-Ascorbic Acid Calcium Salt Hydrate; L-Ascorbic Acid Calcium Salt Dihydrate; Calcium L-ascorbate dihydrate; L-Ascorbic acid, calcium salt, hydrate (2:1:2); L-Ascorbic acid, calcium salt (2:1), dihydrate. Grade: 98%. CAS No. 5743-28-2. Molecular formula: C12H14O12Ca.2H2O. Mole weight: 426.36. | |
| Calcium channel-modulator-1 | A calcium channel modulator that blocks aortic contraction (IC50= 0.8 μM). Synonyms: 3-O-methyl 5-O-[3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propyl] 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide. CAS No. 136941-70-3. Molecular formula: C26H24Cl2N2O7S. Mole weight: 579.45. | |
| Calcium-D-arabonate | Calcium-D-arabonate is a pivotal compound, used for the research of calcium inadequacies and skeletal ailments such as osteoporosis, osteomalacia and analogous afflictions. Synonyms: Calcium arabinoate; Arabinonic acid, Ca salt; D-Arabinonic acid, calcium salt (2:1). CAS No. 22373-09-7. Molecular formula: C10H18CaO12. Mole weight: 370.32. | |
| Calcium D-saccharate tetrahydrate | Calcium D-saccharate tetrahydrate is a biomedical compound used in the research of conditions related to calcium deficiencies, such as osteoporosand hypocalcemia. Synonyms: D-Glucaric acid, calcium salt, hydrate (1:1:4); D-Saccharic acid calcium salt tetrahydrate; Glucaric acid calcium salt tetrahydrate; Calcium D-glucarate tetrahydrate; Glucosaccharic acid calcium salt tetrahydrate; D-Glucaric acid, calcium salt (1:1), tetrahydrate; Glucaric acid, calcium salt, tetrahydrate, D-; Calcium D-saccharate tetrahydrate. Grade: 98%. CAS No. 5793-89-5. Molecular formula: C6H8CaO8.4H2O. Mole weight: 320.26. | |
| Calcium glucoheptonate | Calcium glucoheptonate is a calcium supplement. Synonyms: D-gluco-Heptonic acid, calcium salt (2:1), (2ξ)-; Glucoheptonic acid, calcium salt (2:1); Calcihept; Calcium gluceptate; Calcium heptagluconate; Glucoheptonic acid calcium salt. CAS No. 29039-00-7. Molecular formula: C14H26O16Ca. Mole weight: 490.44. | |
| Calcium gluconate | Gluconate Calcium is a calcium supplement used in crop pesticide formulations and also in the treatment of too little calcium in the blood. Synonyms: Calcium D-gluconate; 2,3,4,5,6-Pentahydroxycaproic acid hemicalcium salt; D-Gluconic acid, calcium salt (2:1); Gluconic acid, calcium salt (2:1), D-; Biocal; Calcicol; Calciofon; Calcipur; Calcium D-gluconate; Calcium hexagluconate; Calglucol; Calglucon; Dragocal; Ebucin; Glucal; Glucobiogen; Kalpren; Novocal. Grade: ≥95%. CAS No. 299-28-5. Molecular formula: C12H22CaO14. Mole weight: 430.37. | |
| Calcium Glycerophosphate | Calcium Glycerophosphate is a mineral supplement. Synonyms: Calcium 1-glycerophosphate; Calcium glycerol phosphate; 1,2,3-Propanetriol, 1-(dihydrogen phosphate), calcium salt (1:1). Grade: ≥95%. CAS No. 27214-00-2. Molecular formula: C3H7CaO6P. Mole weight: 210.14. | |
| Calcium ionophore I | Calcium ionophore I is a selective Ca2+ ionophore for biological membranes that can be used in microelectrodes for the quantitative determination of intracellular resting Ca2+ activities and of slowly changing Ca2+ levels. Synonyms: ETH 1001; (17R,18R)-diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontane-1,34-dioate; diethyl [R-(R*,R*)]-13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontanedioate; (-)-(R,R)-N,N'-Bis-[11-(ethoxycarbonyl)undecyl]-N,N',4,5-tetramethyl-3,6-dioxaoctane-diamide. Grade: 95%. CAS No. 58801-34-6. Molecular formula: C38H72N2O8. Mole weight: 684.99. | |
| Calcium lactate gluconate | Calcium lactate gluconate, also known as GLOCAL, is a soluble salt of calcium, lactic acid and gluconic acid used in effervescent calcium tablets. Its chemical formula is Ca5(C3H5O3)6·(C6H11O7)4·2H2O. It was first developed by Sandoz, Switzerland. Calcium lactate gluconate is used in the functional and fortified food industry due to its good solubility and neutral taste. In addition, it is used in various spherification techniques in molecular gastronomy. It can also be used to help neutralize HF (hydrofluoric acid) poisoning. Synonyms: (Gluconato)(lactato)calcium. CAS No. 11116-97-5. Molecular formula: (C3H5O3)2Ca (C6H11O7)2Ca. Mole weight: 648.59. | |
| Calcium lactobionate | Calcium lactobionate, known for its significant biomedical applications, acting as an indispensable excipient. It plays a vital role in fortifying compound formulations, thereby bolstering their steadfastness and optimizing their delivery to target areas. Synonyms: 4-O-b-D-Galactopyranosyl-D-gluconic acid calcium salt; Calcium galactogluconate. CAS No. 5001-51-4. Molecular formula: C24H42CaO24. Mole weight: 754.65. | |
| Calcium-L(-)-arabonate tetrahydrate | Calcium-L(-)-arabonate tetrahydrate is an esteemed pharmaceutical compound, manifesting exceptional prowess in studying and precluding maladies stemming from calcium insufficiency. Its profound efficacy as a supplemental source of calcium fosters the fortification of osseous vitality. Synonyms: L(-)-Arabonic acid calcium salt. Molecular formula: C10H26CaO16. Mole weight: 442.38. | |
| Calcium Levofolinate | Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. Synonyms: Saponins. Grade: >98%. CAS No. 80433-71-2. Molecular formula: C20H21CaN7O7. Mole weight: 511.5. | |
| Calcium Levomefolate | The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. Synonyms: Levomefolate calcium. Grade: >98%. CAS No. 151533-22-1. Molecular formula: C20H23N7O6.Ca. Mole weight: 499.53. | |
| Calcium L-threonate | Empowered with remarkable and expedited absorptive traits, Calcium L-Threonate emerging as an extraordinary entity in the research of calcium supplements. This unique compound can be used in research of osteoporosis and bone fractures. Synonyms: L-Threonic acid calcium salt; (2R, 3S)-2,3,4-Trihydroxbutyric acid hemicalcium salt. CAS No. 70753-61-6. Molecular formula: C8H14CaO10. Mole weight: 310.27. | |
| Calcium N5-methyltetrahydrofolate | Calcium N5-methyltetrahydrofolate is a metabolite of folic acid. It was shown to inhibit photosensitization reactions and strand breaks in DNA, and reduce total serum homocysteine level in orthotopic liver transplant recipients. Synonyms: Calcium methyltetrahydrofolate; NSC 173328; NSC-173328; NSC173328. Grade: >98%. CAS No. 26560-38-3. Molecular formula: C20H23CaN7O6. Mole weight: 497.52. | |
| Calcium pantothenate EP Impurity H | An impurity of Calcium pantothenate. Calcium pantothenate is a water-soluble vitamin B5 derivative used as a dietary supplement and additive in food, feed, and cosmetics. Synonyms: 3-[(5Ξ)-5-(1-hydroxy-2-methylpropan-2-yl)-4-oxo-1,3-oxazolidin-3-yl]propanoic acid; Pantothenic Acid EP Impurity H; Calcium pantothenate Impurity H; Pantothenic Acid Impurity H. Molecular formula: C10H17NO5. Mole weight: 231.25. | |
| Calcium Phosphate Dibasic Dihydrate | Calcium Phosphate Dibasic Dihydrate is widely used in tablet formulations, both as an excipient and as a source of calcium and phosphorus in nutritional supplements, and as a tablet and capsule diluent. Synonyms: calcium hydrogenphosphate dihydrate; Calcium hydrogen phosphate dihydrate; Dicalcium phosphate dihydrate; Calcium monohydrogen phosphate dihydrate; Dibasic Calcium Phosphate Dihydrate; Phosphoric acid, calcium salt (1:1), dihydrate; Calcium phosphate dihydrate, dibasic; brushite; Aksepillen; Eunova. Grade: ≥95%. CAS No. 7789-77-7. Molecular formula: H5CaO6P. Mole weight: 172.09. | |
| Calcium propionate | Calcium Propionate is an antifungal agent.It can also be used as a food preservative. Synonyms: calcium; propanoate. Grade: > 95 %. CAS No. 4075-81-4. Molecular formula: C6H10CaO4. Mole weight: 186.22. | |
| Calcium-Sensing Receptor Antagonists I | Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grade: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45. | |
| Calcium trinatrium diethylenetriaminepentaacetic acid hydrate | Calcium trinatrium diethylenetriaminepentaacetic acid hydrate is a metal chelator and useful antidote (such as acute cadmium intoxication), as well as a non-toxic CMV replication inhibitor. Synonyms: Ca-DTPA trisodium salt hydrate; Diethylenetriamine-pentaacetic Acid Calcium Trisodium Salt hydrate; Calcium sodium 2,2',2'',2''',2''''-(1,2-ethanediylnitrilo)pentaacetate hydrate (1:3:1:x). Grade: ≥95%. CAS No. 207226-35-5. Molecular formula: C14H18CaN3Na3O10.xH2O. Mole weight: 497.35 (anhydrous). | |
| Caldaret | Caldaret is an intracellular Ca2+ handling modulator. It acts through reverse mode Na+/Ca2+ exchanger inhibition. Synonyms: Benzenesulfonic acid, 5-methyl-2-(1-piperazinyl)-; MCC 135; 2-(1-piperazinyl)-5-methylbenzenesulfonic acid. Grade: 95%. CAS No. 133804-44-1. Molecular formula: C11H16N2O3S. Mole weight: 256.32. | |
| CAL Fluor Red 610 CE Phosphoramidite | CAL Fluor Red 610 CE Phosphoramidite, a highly sensitive and reliable fluorescent dye, is commonly applied for the real-time PCR detection and quantification of nucleic acid targets relevant to the diagnosis and management of various diseases, including cancer and viral infections, rendering it an indispensable asset to the biomedical research community and clinical diagnostic industry. Synonyms: 1H,5H,11H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium, 9-[2-[[4-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]-1-piperidinyl]carbonyl]phenyl]-2,3,6,7,12,13,16,17-octahydro-, hexafluorophosphate(1-) (1:1); CAL Fluor Red 610 Amidite; CAL Fluor Red 610; CFR 610 Amidite. Grade: 95%. CAS No. 861143-34-2. Molecular formula: C46H57N5O4P2F6P. Mole weight: 919.93. | |
| CAL Fluor Red 610 CPG 1000 | CAL Fluor Red 610 CPG 1000 is a fluorescent dye extensively employed acting as a preeminent labeling compound. It facilitates the detection and analysis of distinctive targets, encompassing DNA, RNA and proteins. Moreover, this remarkable compound assumes a pivotal role delivery systems and molecular imaging, attributable to its unparalleled photostability and conspicuous red fluorescence. | |
| Calhex 231 | Calhex 231 has been found to be a new calcium sensing receptor ligand. Synonyms: Calhex231; Calhex-231; Benzamide, 4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-. Grade: ≥98% by HPLC. CAS No. 652973-93-8. Molecular formula: C25H27ClN2O. Mole weight: 406.9. | |
| Calindol hydrochloride | The calcium sensing receptor (CaSR) has a long amino terminal tail typical of family 3 of GPCRs including the metabotropic glutamate receptors, the c-aminobutyric acid B receptor and certain pheromone and taste receptors. Calindol hydrochloride is a new calcimimetic compound acting as (CaSR). It is a positive allosteric modulator of the human Ca2+ receptor which activates an extracellular ligand-binding domain-deleted, Rhodopsin-like, seven-transmembrane structure in the absence of Ca2+. Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues. Synonyms: Calindol. Grade: ≥98%. CAS No. 729610-18-8. Molecular formula: C21H20N2·HCl. Mole weight: 336.9. | |
| Calmidazolium chloride | Calmidazolium chloride has been found to be a calcium channel protein inhibitor as well as a calmodulin antagonist. Synonyms: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride. Grade: ≥98% by HPLC. CAS No. 57265-65-3. Molecular formula: C31H23Cl7N2O. Mole weight: 687.70. | |
| Calmodulin antagonist-1 | Calmodulin antagonist-1 is a calmodulin (CaM) antagonist that inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50 = 28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50 = 375 μM) in a competitive fashion with respect to cyclic GMP (Ki = 300 μM). Uses: Neoplasm inhibitor. Synonyms: N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride; W8 Hydrochloride; N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Monohydrochloride. Grade: ≥95%. CAS No. 78957-84-3. Molecular formula: C14H18Cl2N2O2S. Mole weight: 349.28. | |
| Calmodulin-Dependent Protein Kinase II (290-309) trifluoroacetate salt | Calmodulin-dependent protein kinase II (290-309) is a synthetic peptide derived from the rat brain protein sequence that contains the calmodulin binding domain. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC50 value of 52 nM and CaMKII-dependent phosphodiesterase activity with IC50 of 1.1 nM. Calmodulin-dependent protein kinase II (290-309) has been used in the study of CaM binding, autophosphorylation, and dynamics. Grade: ≥95%. Molecular formula: C103H185N31O24S·xCF3COOH. Mole weight: 2273.83. | |
| Caloxin 2A1 TFA | Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. It does not affect basal Mg2+-ATPase or Na+-K+-ATPase. Molecular formula: C66H92F3N19O24. Mole weight: 1592.54. | |
| CALP1 | CALP1 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site and activating phosphodiesterase. CALP1 also binds to cytoplasmic sites on other Ca2+ channels such as NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). It was shown to suppress VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo. Synonyms: Calcium-like peptide 1. CAS No. 145224-99-3. Molecular formula: C40H75N9O10. Mole weight: 842.09. | |
| CALP1 acetate | CALP1 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site and activating phosphodiesterase. CALP1 also binds to cytoplasmic sites on other Ca2+ channels such as NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). It was shown to suppress VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo. Synonyms: Calcium-like peptide 1 acetate. Molecular formula: C42H79N9O12. Mole weight: 902.13. | |
| CALP1 TFA | CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 μM) by inhibiting the open of calcium channel. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity. Synonyms: L-valyl-L-alanyl-L-isoleucyl-L-threonyl-L-valyl-L-leucyl-L-valyl-L-lysine,trifluoroacetatesalt. Molecular formula: C42H76F3N9O12. Mole weight: 956.10. | |
| CALP1 trifluoroacetate salt | CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. CALP1 is also a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. CALP1 inhibits Ca2+-mediated cytotoxicity and apoptosis with IC50 of 52 μM and activates phosphodiesterase in the presence of calmodulin and absence of calcium. It also decreases radical production induced by phorbol 12-myristate 13-acetate in broncho-alveolar lavage cells. Synonyms: Calcium-like peptide 1. Grade: ≥95%. Molecular formula: C40H75N9O10·xCF3COOH. Mole weight: 842.08. | |
| Calpain Inhibitor I | MG-101, also known as Calpain Inhibitor I and ALLN, is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid, (2) overcome acquired resistance to TRAIL, (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid. Synonyms: (S)-N-Acetyl-L-leucyl-N-(1-formylpentyl)-L-leucinamide; ALLN; ALLnL; CI-1 (peptide); Calp I; Calpain inhibitor I; MG 101; (S)-N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal; MG-101. Grade: 98 %. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.52. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grade: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Calpain Inhibitor VI | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grade: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. | |
| Calpain Inhibitor XII | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grade: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
| Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Uses: Cysteine proteinase inhibitors. Synonyms: Benzylcarbonyl-leu-nleu-H; Cbz-Leu-Nle-al. Grade: >98%. CAS No. 117591-20-5. Molecular formula: C20H30N2O4. Mole weight: 362.46. | |
| Calteridol | Desgadolinium Gadoteridol is an impurity of Gadoteridol. Gadoteridol is a gadolinium-based MRI contrast agent. It is sold under the brand name ProHance. Synonyms: calteridol; CHEBI:37387; 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid,10-(2-hydroxypropyl)-; 2,2',2'-[10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl]triacetic acid; ACMC-20mop4. Grade: 95%. CAS No. 120041-08-9. Molecular formula: C17H32N4O7. Mole weight: 404.46. | |
| CALYCULIN A | Calyculin A is a effective inhibitor of the catalytic subunit of type-2A phosphatase as well as the type-1 phosphatase. IC50: 0.5 to 1 nM and 2 nM,respectively. It has lower IC50 value than okadaic acid which is a active blocker of phosphatase mentioned a. Uses: Calyculin a is a effective inhibitor of the catalytic subunit of type-2a phosphatase as well as the type-1 phosphatase. Synonyms: CALYCULIN A; CALYCULIN A, DISCODERMIA CALYX; calyculin A from discodermia calyx; CALYCULIN A FROM DISCODERMIA CALYX, 10 U G; N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam; L-Ribonamide. Grade: >98 %. CAS No. 101932-71-2. Molecular formula: C50H81N4O15P. Mole weight: 1009.17. | |
| Calystegine B2 | Calystegine B2 is a bioactive compound known for its potential therapeutic properties in studying neurodegenerative diseases, such as Alzheimer's and Parkinson's. Extensive research has revealed its ability to inhibit enzymes involved in the progression of these diseases, making it a promising candidate for drug development. Synonyms: Nortropanoline; 8-Aza-bicyclo[3.2.1]octane-1,2,3,4-tetraol. CAS No. 127414-85-1. Molecular formula: C7H13NO4. Mole weight: 175.19. | |
| Cambinol | Cambinol is a cell-permeable inhibitor of SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Synonyms: 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone; Cambinol; NSC 112546; SIRT1 Inhibitor II; SIRT2 Inhibitor VI; SIRT 1/2 inhibitor IV; NSC112546; NSC-112546; NSC 112546. CAS No. 14513-15-6. Molecular formula: C21H16N2O2S. Mole weight: 360.43. | |
| Camidanlumab | Camidanlumab is a monoclonal antibody targeting CD25, which is expressed on activated T cells. Camidanlumab can be used in the synthesis of ADC Camidanlumab tesirine, which is investigated for the treatment of lymphoma and leukemia. Synonyms: HuMax-TAC. CAS No. 921618-45-3. | |
| CAM-IN-1 | A potent and selective inhibitor of E-selectin (IC50= 7 nM) and ICAM-1 (IC50= 5 nM). Synonyms: Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-. CAS No. 251994-14-6. Molecular formula: C15H11BrN2O2S. Mole weight: 363.23. | |
| Camizestrant | Camizestrant is an orally available selective estrogen receptor degrader (SERD), with potential antineoplastic activity. Synonyms: N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine; Estrogen receptor antagonist 2; AZD-9833; AZD 9833; AZD9833; NSC-828717; N-[1-(3-Fluoropropyl)-3-azetidinyl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-3-pyridinamine. Grade: ≥98%. CAS No. 2222844-89-3. Molecular formula: C24H28F4N6. Mole weight: 476.51. | |
| CaMKII-IN-1 | CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. Synonyms: CaMKII-IN-1; CaMKII; CaMKII IN-1; CaMKII IN 1; CaMKII-IN 1. Grade: >98%. CAS No. 1208123-85-6. Molecular formula: C29H30ClN5O2S. Mole weight: 548.1. | |
| CaM kinase II inhibitor TFA salt | Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM. Molecular formula: C66H117F3N22O21. Mole weight: 1611.76. | |
| CaMKP Inhibitor | CaMKP Inhibitor is a competitive substrate inhibitor of POPX2 (Ca2+/CaMKP) and POPX1 (nuclear isoform CaMKP-N). Synonyms: 1,3-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-, sodium salt (1:1); 1,3-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-, monosodium salt; 8-Amino-1-naphthol-5,7-disulfonic acid monosodium salt. Grade: ≥95%. CAS No. 52789-62-5. Molecular formula: C10H8NNaO7S2. Mole weight: 341.29. | |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Synonyms: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305. Grade: >98%. CAS No. 59721-29-8. Molecular formula: C20H22N4O5.CH4O3S. Mole weight: 494.52. | |
| cAMP-AM | cAMP-AM is a membrane-permeant precursor of cAMP, the second messenger. cAMP is released after permeation and metabolism of cAMP-AM by esterases, then it is metabolized to produce a pulse-type signal. Synonyms: Adenosine- 3', 5'- monophosphate, acetoxymethyl ester. Grade: ≥ 97% by HPLC for mixture of isomers. CAS No. 159764-93-9. Molecular formula: C13H16O8N5P. Mole weight: 401.3. | |
| cAMP-Bn | cAMP-Bn is a precursor of cAMP, the second messenger. The polar cAMP is released after cAMP-Bn is hydrolyzed to produce an elevated cAMP level for a prolonged period. Synonyms: Adenosine- 3', 5'- monophosphate, benzyl ester. Grade: ≥ 95% by HPLC for mixture of isomers. CAS No. 62742-71-6. Molecular formula: C17H18N5O6P. Mole weight: 419.3. | |
| Campesterol | Campesterol is a phytosterol, primarily found in nuts, fruits, legumes and seeds. It is poorly absorbed in humans and competitively inhibits the absorption of cholesterol. lt decreases the transcription of genes involved in cholesterol metabolism in hepatocytes and enterocytes and has positive impact in treatment of cardiovascular disease. lt was used as standard in GC1 and HPLC2 analysis of oil samples from plants. Synonyms: Campest-5-en-3beta-ol; Ergost-5-en-3beta-ol, (24R)-; Ergost-5-en-3-ol, (3beta,24R)-; 24α-Methyl-5-cholesten-3β-ol. Grade: >98%. CAS No. 474-62-4. Molecular formula: C28H48O. Mole weight: 400.68. | |
| Camptothecin | Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. Camptothecin is extratced from the barks of Camptotheca acuminata Decne. It can be used in cosmetics material. It is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Uses: Adcs cytotoxin. Synonyms: camptothecin; 7689-03-4; Camptothecine; (S)-(+)-Camptothecin; Campathecin; (+)-Camptothecin; (+)-Camptothecine; d-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; Camptothecine (S,+); CHEMBL65; (S)-4-ethyl-4-hydroxy-1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC-94600; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol. Grade: >98%. CAS No. 7689-3-4. Molecular formula: C6H14N2O2.ClH. Mole weight: 182.65. | |
| Camrelizumab | Camrelizumab is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma. Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities. Synonyms: Immunoglobulin G4, anti-(cell surface receptor) (human-Mus musculus monoclonal SHR-1210 heavy chain), disulfide with human-Mus musculus monoclonal SHR-1210 light chain, dimer; AiRuiKa; HR 301210; Immunoglobulin G4, anti-(human programmed cell death protein 1) (human-Mus musculus monoclonal SHR-1210 heavy chain), disulfide with human-Mus musculus monoclonal SHR-1210 light chain, dimer; INCSHR 01210; INCSHR 1210; INCSHR01210; SHR 1210. Grade: ≥98%. CAS No. 1798286-48-2. | |
| Camylofine | Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscle spasm. Synonyms: Camylofine; Acamylophenine; Adopon; Avacan; Novospasmin; 3-methylbutyl 2-[2-(diethylamino)ethylamino]-2-phenylacetate. CAS No. 54-30-8. Molecular formula: C19H32N2O2. Mole weight: 320.477. | |
| Camylofine dihydrochloride | Camylofine dihydrochloride is the salt form of Camylofine. Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscle spasm. Synonyms: 3-Methylbutyl {[2-(diethylamino)ethyl]amino}(phenyl)acetate dihydrochloride. CAS No. 5892-41-1. Molecular formula: C19H34Cl2N2O2. Mole weight: 393.393. | |
| Canagliflozin 2-Glucuronide | Canagliflozin 2-glucuronide is a derivative of Canagliflozin. Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion. Synonyms: Canagliflozin metabolite M5; (2S,3S,4S,5R,6R)-6-(((2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; 1-(2-O-β-D-Glucuronide-β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene. Grade: 96%. CAS No. 2648415-15-8. Molecular formula: C30H33FO11S. Mole weight: 620.64. | |
| Canagliflozin 3-Glucuronide | Canagliflozin 3-glucuronide is a derivative of Canagliflozin. Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that is used to treat patients with type 2 diabetes. Canagliflozin lowers blood glucose by increasing the amount of glucose that exits the body through urinary excretion. Synonyms: Canagliflozin metabolite M7; (2S,3S,4S,5R,6R)-6-(((2S,3S,4R,5R,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; 1-(3-O-β-D-Glucuronide-β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene. Grade: 96%. CAS No. 2648415-13-6. Molecular formula: C30H33FO11S. Mole weight: 620.64. | |
| Canagliflozin 3-O-β-D-glucuronide | Canagliflozin 3-O-β-D-glucuronide is an impurity of Canagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol. Molecular formula: C30H33FO11S. Mole weight: 620.64. | |
| Canagliflozin alpha-Isomer Impurity | epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: (1R)-1,5-Anhydro-1-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-D-glucitol; epi-Canagliflozin; D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1R)-; (1R)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol; (2R,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; Canagliflozin alpha-Isomer; Canagliflozin α-isomer. Grade: ≥95%. CAS No. 1589590-87-3. Molecular formula: C24H25FO5S. Mole weight: 444.53. | |
| Canagliflozin Defluoro Impurity | Defluoro-Canagliflozin is an impurity of Canagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity. Synonyms: Canagliflozin Impurity A; Canagliflozin Desfluoro Impurity; D-Glucitol, 1,?5-anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-, (1S)?-; (1S)-1,?5-Anhydro-1-C-[4-methyl-3-[(5-phenyl-2-thienyl)?methyl]?phenyl]?-D-glucitol; Desfluoro Canagliflozin; (2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(4-methyl-3-((5-phenylthiophen-2-yl)methyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol. Grade: ≥95%. CAS No. 842133-16-8. Molecular formula: C24H26O5S. Mole weight: 426.54. | |
| Canagliflozin Furanose Form (Mixture of Anomers) | Canagliflozin Furanose Form (Mixture of Anomers) is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Galactitol, 1,4-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-; Canagliflozin-10; Canagliflozin Impurity 17; (2R,3R,4R,5R)-2-((R)-1,2-dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol. CAS No. 2161394-94-9. Molecular formula: C24H25FO5S. Mole weight: 444.52. | |
| Canagliflozin hemihydrate | Canagliflozin hemihydrate is a highly potent and selective inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. It is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes. Uses: The potential treatment of type 2 diabetes. Synonyms: (3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate; JNJ 28431754 hemihydrate; TA 7284 hemihydrate; JNJ-24831754-ZAE hemihydrate; JNJ-28431754-AAA hemihydrate; (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1); Cagliflozin hydrate; Invokana hemihydrate; 1-(β-D-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate. Grade: >98%. CAS No. 928672-86-0. Molecular formula: C24H25FO5S.1/2H2O. Mole weight: 453.53. | |
| Canagliflozin Impurity 14 | Canagliflozin Impurity 14 is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(3-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-; (2S,3R,4R,5S,6R)-2-(3-((5-(3-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 842133-17-9. Molecular formula: C24H25FO5S. Mole weight: 444.52. | |
| Canagliflozin Impurity 17 | Canagliflozin Impurity 17 is an impurity of Canagliflozin, which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor used in the treatment of type 2 diabetes and obesity. Synonyms: Methanone, [5-(4-fluorophenyl)-2-thienyl](5-β-D-glucopyranosyl-2-methylphenyl)-; Methanone, (5-(4-fluorophenyl)-2-thienyl)(5-beta-D-glucopyranosyl-2-methylphenyl)-; Canagliflozin impurity 12; (5-(4-Fluorophenyl)thiophen-2-yl)(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanone; [5-(4-Fluorophenyl)-2-thienyl](5-β-D-glucopyranosyl-2-methylphenyl)methanone; Canagliflozin Impurity 2; Canagliflozin Keto Impurity. Grade: ≥95%. CAS No. 1951467-28-9. Molecular formula: C24H23FO6S. Mole weight: 458.50. | |
| Canagliflozin Monoacetyl Impurity | Canagliflozin Monoacetyl Impurity is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: ((2R,3S,4R,5R,6S)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl acetate; Canagliflozin impurity 03. CAS No. 2146135-87-5. Molecular formula: C26H27FO6S. Mole weight: 486.55. | |
| Canagliflozin Related Impurity 10 | an impurity of Canagliflozin. Synonyms: β-D-Glucopyranose, 1-C-[3-[[5-(4-fluorophenyl)?-2-thienyl]?methyl]?-4-methylphenyl]?-. Grade: > 95%. CAS No. 1799552-91-2. Molecular formula: C24H25FO6S. Mole weight: 460.53. | |
| Canagliflozin Related Impurity 14 | 2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. Synonyms: Thiophene, 2-(4-fluorophenyl)?-. Grade: > 95%. CAS No. 58861-48-6. Molecular formula: C10H7FS. Mole weight: 178.23. | |
| Canagliflozin Related Impurity 9 | an impurity of Canagliflozin. Synonyms: (3R,4S,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one. Grade: > 95%. CAS No. 32384-65-9. Molecular formula: C18H42O6Si4. Mole weight: 466.86. | |
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