BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BSJ-03-123 | BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions; induces differential E3 ligase recruitment and ensuing degradation of CDK6, but not CDK4. Synonyms: BSJ 03-123; BSJ 03 123; BSJ-03 123; BSJ03123; N-[2-(2-{2-[2-(4-{6-[(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-1-piperazinyl)ethoxy]ethoxy}ethoxy)ethyl]-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide; Acetamide, N-[2-[2-[2-[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-. Grade: ≥95%. CAS No. 2361493-16-3. Molecular formula: C47H56N10O11. Mole weight: 937.01. |  |
| BSJ-Bump | BSJ-Bump is the negative control for BSJ-03-123. It displays binding and no degradation of cyclin dependent kinases 6 (CDK6) in vitro. Synonyms: N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide. Grade: ≥98%. CAS No. 2409918-48-3. Molecular formula: C48H58N10O11. Mole weight: 951.05. | |
| BT173 | BT173 is a novel HIPK2 inhibitor that attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway and may be developed as an antifibrotic therapy in patients with kidney disease. Synonyms: BT-173; BT 173. Grade: >98%. CAS No. 2232180-74-2. Molecular formula: C18H12BrN3O2. Mole weight: 382.22. | |
| BT2 | BT2 is an allosteric inhibitor of branched-chain α-ketoacid dehydrogenase (BCKDC) kinase (BDK; IC50 = 3.19 μM). BT2 can dissociate BDK from BCKDC via binding to BDK. Synonyms: BT2; BT-2; BT 2; 3,6-Dichloro-1-benzothiophene-2-carboxylic acid. Grade: 99%. CAS No. 34576-94-8. Molecular formula: C9H4Cl2O2S. Mole weight: 247.1. | |
| BT44 | BT44 is a RET agonist for the treatment of neurodegenerative disorders. Synonyms: BT 44; BT-44. Grade: >98%. CAS No. 924759-42-2. Molecular formula: C28H27F4N3O4S. Mole weight: 577.59. | |
| BTA-EG4 hydrate | BTA-EG4 is an inhibitor of protein-amyloid interaction. BTA-EG4 significantly reduced tau phosphorylation in the absence of any changes in the amounts of amyloid precursor protein, amyloid-β or synaptic proteins. Grade: >98%. CAS No. 921193-28-4. Molecular formula: C22H28N2O4S.xH2O. Mole weight: 416.53 (anhydrous basis). | |
| BTB 02472 | BTB 02472 is an active-site-targeting COX-2 inhibitor. Synonyms: COX-2 Inhibitor III; N-(5-Acetyl-2-piperidinophenyl)-N' -(2,5-dichlorophenyl)thiourea. CAS No. 1177728-24-3. Molecular formula: C20H23Cl2N3OS. Mole weight: 424.39. | |
| BTB06584 | BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. It may represent a valuable tool to selectively inhibit mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase. Synonyms: BTB06584; BTB-06584; BTB 06584. Grade: >98%. CAS No. 219793-45-0. Molecular formula: C19H12ClNO6S. Mole weight: 417.82. | |
| BTB-1 | BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A's MT-stimulated ATPase activity, with an IC50 of 1.7-1.9 M. It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A's MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A's double functionality within mitosis and assessing for potential therapeutic utilities. Synonyms: BTB 1; BTB1; 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; 4-Chloro-2-nitrodiphenyl sulfone; NSC 156750. CAS No. 86030-08-2. Molecular formula: C12H8ClNO4S. Mole weight: 297.71. | |
| BTK IN-1 | BTK IN-1 is a non-covalently binding inhibitor of Bruton's tyrosine kinase (BTK). Synonyms: SNS062-analog; SNS-062 analog; N-(1-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-2-((3-chlorophenyl)amino)acetamide. Grade: 98%. CAS No. 1270014-40-8. Molecular formula: C19H21ClN6O. Mole weight: 384.86. | |
| BTK-IN-5 | BTK-IN-5 is a covalent BTK inhibitor for the treatment of cardiovascular disease, respiratory disease, inflammation and diabetes. Synonyms: (S)-N-((2S,3R)-3-(tert-butoxy)-1-(((R)-3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)-2-methyloxirane-2-carboxamide. CAS No. 2145152-06-1. Molecular formula: C23H32N4O5. Mole weight: 444.52. | |
| Btk inhibitor 1 | Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1. Grade: >98%. CAS No. 1412418-47-3. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| BTK inhibitor 10 | BTK inhibitor 10, a potent and orally active BTK inhibitor, has a potential for rheumatoid arthritis treatment. (Extracted from patent WO2018145525, example 33). Synonyms: BTK-030; N-[3-({6-[4-(4-Morpholinyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]acrylamide; 2-Propenamide, N-[3-[[6-[4-(4-morpholinyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-. Grade: 98%. CAS No. 2241732-30-7. Molecular formula: C25H23N5O3. Mole weight: 441.48. | |
| BTK inhibitor 13 | BTK inhibitor 13 is a potent and selective BTK inhibitor with an IC50 of 1.2 nM. Synonyms: N-{3-[5-(N-Acryloyl-N-methylglycyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-5-fluoro-2-methylphenyl}-4-cyclopropylbenzamide; Benzamide, 4-cyclopropyl-N-[5-fluoro-2-methyl-3-[5-[2-[methyl(1-oxo-2-propen-1-yl)amino]acetyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-. Grade: 98%. CAS No. 2376726-26-8. Molecular formula: C29H26FN5O3. Mole weight: 511.55. | |
| BTK inhibitor 19 | BTK inhibitor 19 is a highly selective and covalent BTK inhibitor with an IC50 of 2.7 nM. Synonyms: 1H-Imidazole-5-carboxamide, 1-amino-2-[(2S)-1-(1-oxo-2-propen-1-yl)-2-piperidinyl]-4-[4-[[[4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]phenyl]-; (S)-2-(1-acryloylpiperidin-2-yl)-1-amino-4-(4-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)-1H-imidazole-5-carboxamide. CAS No. 2557174-19-1. Molecular formula: C25H24F3N7O3. Mole weight: 527.50. | |
| BTK inhibitor 1 (Compound 27) | BTK inhibitor 1 is an inhibitor of BTK with IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with IC50 of 2 nM. Synonyms: DC20199; Compound 27. Grade: ≥98%. CAS No. 2230724-66-8. Molecular formula: C24H23FN8O2. Mole weight: 474.49. | |
| Btk inhibitor 1 R enantiomer | Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: 3-(4-phenoxyphenyl)-1-[(3R)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine; (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-. Grade: ≥98% by HPLC. CAS No. 1022150-12-4. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| Btk inhibitor 1 R enantiomer hydrochloride | Btk inhibitor 1R enantiomer Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Synonyms: Btk inhibitor 1 R enantiomer hydrochloride. Grade: >98%. CAS No. 1553977-42-6. Molecular formula: C22H23ClN6O. Mole weight: 422.91. | |
| BTK inhibitor 2 | Bruton's tyrosine kinase (BTK), also known as tyrosine-protein kinase BTK, is an enzyme that in humans is encoded by the BTK gene. BTK is a kinase that plays a crucial role in B-cell development. Btk inhibitor 2 is a BTK inhibitor. Grade: ≥98%. CAS No. 1558036-85-3. Molecular formula: C24H25N5O3. Mole weight: 431.49. | |
| BTM-1086 | BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent. Synonyms: BTM1086; cis-2,3-dihydro-3-[(4-methylpiperazinyl)methyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one. CAS No. 72293-17-5. Molecular formula: C21H25N3OS. Mole weight: 367.51. | |
| BTO-1 | BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications. Synonyms: 5-Cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide. Grade: ≥97%. CAS No. 40647-02-7. Molecular formula: C9H4N4O4S. Mole weight: 264.22. | |
| BTR-1 | BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death. Synonyms: 3-ethyl-5-(phenylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one. Grade: 99%. CAS No. 18331-34-5. Molecular formula: C12H11NOS2. Mole weight: 249.35. | |
| b-Trisaccharide-APE-HAS | b-Trisaccharide-APE-HAS. Synonyms: Blood Group b trisaccharide-APE-HAS. | |
| b-Trisaccharide-GEL | b-Trisaccharide-GEL. Synonyms: Blood Group b trisaccharide-GEL. | |
| BTS | A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin's interaction with F-actin. Does not affect platelet myosin II. Synonyms: BTS; BnNHTs; N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine. Grade: >98%. CAS No. 1576-37-0. Molecular formula: C14H15NO2S. Mole weight: 261.34. | |
| BTSA1 | BTSA1 is a BAX activator that binds to the N-terminal activation site with high affinity and specificity induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. Synonyms: BTSA1. Grade: ≥98%. CAS No. 314761-14-3. Molecular formula: C21H14N6OS2. Mole weight: 430.51. | |
| BTT 3033 | BTT 3033 is a selective inhibitor of α2β1 integrin (EC50 = 130 nM for α2β1 binding to collagen I) that binds to the α2I domain. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow, and also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Synonyms: BTT-3033; BTT 3033; BTT3033; 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide. Grade: ≥98% by HPLC. CAS No. 1259028-99-3. Molecular formula: C23H20FN5O3S. Mole weight: 465.5. | |
| BTX161 | BTX161 is a thalidomide analogue and a potent CKIα degrader. BTX161 mediates CKIα degradation better than lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2. Synonyms: (S)-3-(4-Methyl-1-oxoisoindolin-2-yl)azepane-2,7-dione. Grade: ≥98%. CAS No. 2052301-24-1. Molecular formula: C15H16N2O3. Mole weight: 272.30. | |
| BTYNB | BTYNB is a potent and selective inhibitor of the binding of IMP1 to c-Myc mRNA (IC50=5 μM). BTYNB is selective and effective for IMP1-positive cancer cell lines. Synonyms: 2-{[(E)-(5-Bromothiophen-2-Yl)Methylidene]Amino}Benzamide. Grade: 98%. CAS No. 304456-62-0. Molecular formula: C12H9BrN2OS. Mole weight: 309.18. | |
| BTYNB isomer | A ring-closed isomer of BTYNB and potential angionesis inhibitor. Synonyms: BTYNB IMP1 inhibitor isomer; 2-(5-Bromothiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one. Grade: 99%. CAS No. 1262217-87-7. Molecular formula: C12H9BrN2OS. Mole weight: 309.18. | |
| BTZ043 | The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials. Synonyms: BZT043; BZT 043; BZT-043; 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one. CAS No. 1161233-85-7. Molecular formula: C17H16F3N3O5S. Mole weight: 431.39. | |
| BTZ043 Racemate | BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis. Synonyms: BTZ 043 Racemate; BTZ-043 Racemate; 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one. Grade: >98%. CAS No. 957217-65-1. Molecular formula: C17H16F3N3O5S. Mole weight: 431.39. | |
| BTZ-N3 | BTZ-N3, a electron deficient nitroaromatic compound, is a potent and selective anti-TB drug candidate. Synonyms: BTZ-N3; BTZN3; BTZ N3. (S)-8-azido-2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one. Grade: >98%. CAS No. 1839081-05-8. Molecular formula: C17H16F3N5O3S. Mole weight: 427.40. | |
| BTZO 1 | BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). BTZO 1 activates antioxidant response element (ARE)-mediated gene expression and inhibits oxidative stress-induced cardiomyocyte apoptosis in vitro. Uses: Cardioprotective. Synonyms: BTZO1; BTZO 1; BTZO-1; 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one. Grade: ≥99% by HPLC. CAS No. 99420-15-2. Molecular formula: C13H8N2OS. Mole weight: 240.28. | |
| BU 224 hydrochloride | BU 224 hydrochloride is a high affinity imidazoline I2 receptor ligand (Ki = 2.1 nM). It acts as an I2 antagonist that antagonizes the effects of imidazoline ligands on morphine antinociception. Synonyms: BU 224 hydrochloride; BU224 hydrochloride; BU-224 hydrochloride; 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride. CAS No. 205437-64-5. Molecular formula: C12H11N3.HCl. Mole weight: 233.7. | |
| BU 226 hydrochloride | BU 226 hydrochloride is a high affinity imidazoline I2 receptor ligand (Ki = 2.7 nM) with > 2000-fold selectivity for I2 imidazoline receptors over α2-adrenoceptors (Ki = 6700 nM). Synonyms: BU 226 hydrochloride; BU226 hydrochloride; BU-226 hydrochloride; 2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride. CAS No. 1186195-56-1. Molecular formula: C12H11N3.HCl. Mole weight: 233.7. | |
| BU 239 hydrochloride | BU 239 hydrochloride is a high affinity imidazoline I2 receptor ligand. Synonyms: BU 239 hydrochloride; BU239 hydrochloride; BU-239 hydrochloride; SR-01000597872; J-012086; SR 01000597872; J 012086; SR01000597872; J012086; 2-(4,5-Dihydroimidazol-2-yl)quinoxaline hydrochloride. CAS No. 1217041-98-9. Molecular formula: C11H10N4.HCl. Mole weight: 234.69. | |
| Bucetin | Bucetin, a phenacetin analog, has antipyretic and analgesic effect. It has been discontinued for showing renal toxicity. Uses: Bucetin, a phenacetin analog, has antipyretic and analgesic effect. Synonyms: N-(3-HYDROXYBUTYRYL)-P-PHENETIDINE; N-(4-ETHOXYPHENYL)-3-HYDROXYBUTANAMIDE; 3-hydroxy-p-butyrophenetidid; 4'-ethoxy-3-hydroxy-butyranilid; betadid; beta-hydroxybutyricacid-p-phenetidide; beta-oxybuttersaeure-p-phenetidid; n-(4-ethoxyphenyl)-3-hydroxy-butanamid. Grade: 98%. CAS No. 1083-57-4. Molecular formula: C12H17NO3. Mole weight: 223.27. | |
| BuChE-IN-TM-10 | BuChE-IN-TM-10 is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. It has potential to treat Alzheimer's disease. Synonyms: TM-10. CAS No. 2313524-95-5. Molecular formula: C32H38N2O3. Mole weight: 498.66. | |
| Bucindolol | Bucindolol is a third-generation, non-selective β-adrenergic receptor blocker that acts on both β1 and β2 receptors. Ki values are 1.61, 1.20 and 68.9 nM for β1-, β2- and α1-adrenoceptors respectively. Bucindolol is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension. It also displays vasodilatory and antihypertensive actions. Synonyms: Benzonitrile, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-; 2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile; DL-Bucindolol; MJ 13105-1; o-(2-Hydroxy-3-((2-indol-3-yl-1,1-dimethylethyl)amino)propoxy)benzonitrile; 2-(3-((1-(1H-indol-3-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)benzonitrile. Grade: ≥98%. CAS No. 71119-11-4. Molecular formula: C22H25N3O2. Mole weight: 363.45. | |
| Bucindolol hydrochloride | Bucindolol is a third-generation, non-selective β-adrenergic receptor blocker used in the treatment of congestive heart failure and hypertension. Uses: Adrenergic beta-antagonists. Synonyms: Benzonitrile, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-, hydrochloride (1:1); Benzonitrile, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-, monohydrochloride; DL-Bucindolol hydrochloride; o-(2-Hydroxy-3-((2-indol-3-yl-1,1-dimethylethyl)amino)propoxy)benzonitrile monohydrochloride; 2-(3-((1-(1H-indol-3-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)benzonitrile hydrochloride. Grade: ≥95%. CAS No. 70369-47-0. Molecular formula: C22H25N3O2.HCl. Mole weight: 399.91. | |
| Bucladesine calcium salt | Bucladesine calcium salt is a membrane permeable selective activator of PKA. It is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Besides, it is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice. Synonyms: Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, calcium salt (2:1); Calcium N6-2'-O-dibutyryl cyclic adenosine-3',5'-monophosphate; Dibutyryl-cAMP calcium salt; DC2797 calcium salt; DC 2797 calcium salt; DC-2797 calcium salt. Grade: >98%. CAS No. 938448-87-4. Molecular formula: C18H24N5O8P.1/2Ca. Mole weight: 488.42. | |
| Bucladesine Impurity 2 | 6-MB-cAMP is a selective stimulator of protein kinase A (cAMP agonist), which is commonly used as an Epac-negative control. Synonyms: N6- Monobutyryladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 97% by HPLC. CAS No. 70253-67-7. Molecular formula: C14H17N5O7P · Na. Mole weight: 421.3. | |
| Bucladesine Sodium Salt | DB-cAMP is a membrane-permeant activator of protein kinase A, the cAMP agonist. Synonyms: Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodium salt (1:1); Butyramide, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt; Dibutyryl 3',5'-cyclic AMP sodium salt; Dibutyryl cyclic AMP monosodium salt; Dibutyryl cyclic AMP sodium salt; Dibutyryl-cAMP sodium salt; Monosodium dibutyryl cyclic AMP; N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt; N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt; N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt; N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt; Sodium dibutyryl 3',5'-cyclic AMP; Sodium dibutyryl cAMP; Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate. Grade: ≥98% by HPLC. CAS No. 16980-89-5. Molecular formula: C18H23N5NaO8P. Mole weight: 491.37. | |
| Buclizine | Buclizine is a first-generation antihistamine with a piperazine core and a diphenylmethyl moiety. It is used to treat motion sickness, nausea, and vertigo by blocking H1 histamine receptors in the central nervous system. Additionally, buclizine has appetite-stimulating properties and is sometimes included in formulations for weight gain. Its sedative effects are due to its ability to cross the blood-brain barrier and interact with histaminergic and muscarinic receptors. Synonyms: 1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperazine; 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine; 1-(p-Chloro-α-phenylbenzyl)-4-(p-tert-butylbenzyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(p-tert-butylbenzyl)-piperazine; 1-(p-tert-Butylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazine; AH 2526; Aphilan R base; Buclifen; Histabuticine; Histabutizine; Histabutyzine; Hitabutyzyne; Posdel; Postafen. Grade: 95%. CAS No. 82-95-1. Molecular formula: C28H33ClN2. Mole weight: 433.03. | |
| Buclizine hydrochloride | Buclizine hydrochloride is an antihistamine and anticholinergic of the piperazine derivative family. Synonyms: Buclizine dihydrochloride; 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride. Grade: > 98%. CAS No. 129-74-8. Molecular formula: C28H35Cl3N2. Mole weight: 505.952. | |
| Buclosamide | Buclosamide, a topical antimycotic agent, is used to treat dermatomycoses. Synonyms: N-Butyl-4-chlorosalicylamide; Benzamide, N-butyl-4-chloro-2-hydroxy-. Grade: 95%. CAS No. 575-74-6. Molecular formula: C11H14ClNO2. Mole weight: 227.69. | |
| Bufexamac | Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe because of allergic reactions. Synonyms: Benzeneacetamide, 4-butoxy-N-hydroxy-; 4-Butoxy-N-hydroxybenzeneacetamide; Acetohydroxamic acid, 2-(p-butoxyphenyl)-; 2-(4-Butoxyphenyl)acetohydroxamic acid; 2-(p-Butoxyphenyl)acetohydroxamic acid; 4-Butoxyphenylacethydroxamic acid; Anderm; Bufexamic acid; CP 1044J3; Droxarol; Droxaryl; Feximac; Flogocid; Flogocid N plastigel; Malipuran; Mofenar; Norfemac; p-Butoxyphenylacethydroxamic acid; p-Butoxyphenylacetohydroxamic acid; Parfenac; Parfenal; Trolab. Grade: >98%. CAS No. 2438-72-4. Molecular formula: C12H17NO3. Mole weight: 223.27. | |
| Buflomedil | Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. Uses: Vasodilator agents. Synonyms: 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-; 2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone; 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon; 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone. Grade: > 95%. CAS No. 55837-25-7. Molecular formula: C17H25NO4. Mole weight: 307.39. | |
| Buflomedil Hydrochloride | Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease. Uses: Vasodilator agents. Synonyms: Buflomedil hydrochloride; Buflomedil HCl; 35543-24-9; Fonzylane; Loftyl; Buflomedil (hydrochloride); 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride; Buflomedil hydrochloride, European Pharmacopoeia (EP) Reference Standard; 1-BUTANONE, 4-(1-PYRROLIDINYL)-1-(2,4,6-TRIMETHOXYPHENYL)-, HYDROCHLORIDE; Buflomedil for peak identification, European Pharmacopoeia (EP) Reference Standard. Grade: >98%. CAS No. 35543-24-9. Molecular formula: C17H25NO4.HCl. Mole weight: 343.85. | |
| Buflomedil impurity (o-desmethyl) | Buflomedil impurity (o-desmethyl) is a biomedical product used in drug analysand pharmaceutical therapy. This impurity is derived from Buflomedil is a drug used to treat peripheral vascular diseases like Raynaud's phenomenon and intermittent claudication. Its inclusion aids in the identification and characterization of Buflomedil's metabolites, facilitating comprehensive drug development and therapeutic efficacy assessment. Synonyms: 70585-57-8; Buflomedil impurity (o-desmethyl)1-(2-hydroxy-4,6-dimethoxyphenyl)-4-pyrrolidin-1-ylbutan-1-one; hydrochlorideo-Desmethyl-Buflomedil Hydrochloride4-(Pyrrolidin-1-yl)-1-(2-hydroxy-4,6-dimethoxyphenyl)butan-1-one Hydrochloride (o-Desmethyl-Buflomedil Hydrochloride). Grade: > 95%. CAS No. 70585-57-8. Molecular formula: C17H26NO3. Mole weight: 292.40. | |
| Buformin | Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Buformin is a potent AMPK activator and acts as an orally active biguanide antidiabetic agent. Synonyms: Imidodicarbonimidic diamide, N-butyl-; Biguanide, 1-butyl-; N-Butylimidodicarbonimidic diamide; 1-Butylbiguanide; Buformine; Butformin; Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; H 224; N1-Butylbiguanide; W 37. Grade: ≥95%. CAS No. 692-13-7. Molecular formula: C6H15N5. Mole weight: 157.22. | |
| Buformin hydrochloride | Buformin is a potent AMPK activator and acts as an orally active biguanide antidiabetic agent. Synonyms: Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:x); Biguanide, 1-butyl-, hydrochloride; Imidodicarbonimidic diamide, N-butyl-, hydrochloride; Adebit; Butylbiguanide hydrochloride; Silubin; Silubin-retard; 1-Butylbiguanide hydrochloride (1:x); Buformine hydrochloride (1:x); Butylbiguanide hydrochloride (1:x). Grade: ≥95%. CAS No. 15537-73-2. Molecular formula: C6H15N5.xHCl. Mole weight: 157.22 (free base). | |
| Buformin monohydrochloride | Buformin hydrochloride is a hydrochloride form of Buformin, clinically used for diabetes mellitus, it is known to improve resistance to insulin in patients by suppressing the expression of glyceraldehyde 3-phosphate dehydrogenase. It can deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation. Synonyms: Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:1); Biguanide, 1-butyl-, monohydrochloride; Imidodicarbonimidic diamide, N-butyl-, monohydrochloride; 1-Butylbiguanide hydrochloride; 1-Butylbiguanide, monohydrochloride; 1-Butyldiguanide hydrochloride; Andere; Biforon; Bigunal; Bufonamin; Bulbonin; Diabrin; Dibetos; Glibutide; Gliporal; Glybutide; Insulamin; Krebon; N-Butylbiguanide hydrochloride; N1-Butyl-biguanide hydrochloride; N1-n-Butylbiguanide hydrochloride; Panformin; Sindiatil; Tidemol; Ziavetine. Grade: ≥95%. CAS No. 1190-53-0. Molecular formula: C6H15N5.HCl. Mole weight: 193.68. | |
| Bufrolin | Bufrolin, a Cromoglycate (histamine release inhibitor) analog, is a high potency agonist of GPR35. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide. Synonyms: Bufroline; Bufrolinum; ICI-74917; 6-Butyl-1,4,7,10-tetrahydro-4,10-dioxo-1,7-phenanthroline-2,8-dicarboxylic acid. CAS No. 54867-56-0. Molecular formula: C18H16N2O6. Mole weight: 356.33. | |
| Bufuralol HCl | Bufuralol HCl is an esteemed pharmaceutical compound renowned for its application in studying both hypertension and angina, exerting its effects through non-selective beta-blockade. Uses: Adrenergic beta-antagonists. Synonyms: (+/-)-Bufuralol Hydrochloride. Grade: > 95%. CAS No. 59652-29-8. Molecular formula: C16H24NO2Cl. Mole weight: 297.83. | |
| Bufuralol hydrochloride | Bufuralol (Ro-34787) is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is potentially useful for the treatment of hypertension. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation. Most beta blockers are aryloxypropanolamine-based, in this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor. Synonyms: Ro 3-4787. Grade: ≥95%. CAS No. 60398-91-6. Molecular formula: C16H23NO2·HCl. Mole weight: 297.8. | |
| Bumetanide EP Impurity B | Bumetanide EP Impurity B is a metabolite of Bumetanide. Bumetanide is a diuretic to eliminate edema caused by heart failure. Synonyms: Desbutyl Bumetanide; Bumetanide Related Compound A (USP); 3-Amino-5-(aminosulphonyl)-4-phenoxybenzoic acid; PF 1578; 3-Amino-4-phenoxy-5-sulfamoylbenzoic Acid. Grade: 95%. CAS No. 28328-54-3. Molecular formula: C13H12N2O5S. Mole weight: 308.31. | |
| Bumetanide EP impurity D | Bumetanide EP impurity D is an analogue of the diuretic, Bumetanide. Synonyms: N-Desbutyl-N-(2-ethylhexyl) Bumetanide; PF 2825; PF-2825. CAS No. 153012-65-8. Molecular formula: C21H28N2O5S. Mole weight: 420.52. | |
| Bumetanide impurity (3-Nitro-4-phenoxy-5-sulfamoylbenzoic Acid) | Bumetanide impurity (3-Nitro-4-phenoxy-5-sulfamoylbenzoic Acid) is an intermediate in the production of Bumetanide. Synonyms: 3-Nitro-4-phenoxy-5-sulfamoyl-benzoic Acid; 3-(Aminosulfonyl)-5-nitro-4-phenoxy-benzoic Acid. Grade: > 95%. CAS No. 28328-53-2. Molecular formula: C13H10N2O7S. Mole weight: 338.30. | |
| Bumetanide Impurity C | Bumetanide Impurity C is an intermediate in the preparation of Bumetanide. Synonyms: Bumetanide Butyl Ester; Butyl 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoate; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic Acid Butyl Ester; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic Acid Butyl Ester. Grade: > 95%. CAS No. 32643-00-8. Molecular formula: C21H28N2O5S. Mole weight: 420.53. | |
| Bunazosin | Bunazosin is an α1-adrenoceptor antagonist that can be used for the treatment of glaucoma. Synonyms: 4-amino-2-(4-butyrylhexahydro-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-quinazoline; 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1h-1,4-diazepin-1-yl]-1-butanone. Grade: 95%. CAS No. 80755-51-7. Molecular formula: C19H27N5O3. Mole weight: 373.45. | |
| Bunazosin hydrochloride | Bunazosin hydrochloride is an α1-adrenoceptor antagonist that can be used for the treatment of glaucoma. Synonyms: 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride; Bunazosin HCl; 1-(4-Amino-6,7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1,4-diazepine hydrochloride; Detantol. Grade: 95%. CAS No. 52712-76-2. Molecular formula: C19H27N5O3.HCl. Mole weight: 409.91. | |
| Bunolol hydrochloride | Bunolol hydrochloride is a beta-adrenergic antagonist used for the treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. Synonyms: rac-Bunolol Hydrochloride; Bunolol HCl. CAS No. 31969-05-8. Molecular formula: C17H26ClNO3. Mole weight: 327.846. | |
| Buparvaquone | Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for the therapy and prophylaxis of all forms of theileriosis. It has been shown to have antileishmanial activity in vitro. It can be used to treat bovine East Coast fever protozoa in vitro, along with the only other substance known - Peganum harmala. It is the only really efficient commercial therapy product in bovine theileriosis, where it has been used since the late 1980s. Synonyms: Butalex. Grade: >98%. CAS No. 88426-33-9. Molecular formula: C21H26O3. Mole weight: 326.43. | |
| Bupirimate | Bupirimate is a pyrimidine-based fungicide used to control powdery mildew in rose and apple plantations. Synonyms: Sulfamic acid, N,N-dimethyl-, 5-butyl-2-(ethylamino)-6-methyl-4-pyrimidinyl ester; Sulfamic acid, dimethyl-, 5-butyl-2-(ethylamino)-6-methyl-4-pyrimidinyl ester; Buprimate; Nimrod; PP 588; 5-Butyl-2-ethylamino-6-methylpyrimidin-4-yl dimethylsulfamate. Grade: 95%. CAS No. 41483-43-6. Molecular formula: C13H24N4O3S. Mole weight: 316.42. | |
| Bupranolol | Bupranolol is an orally active, competitive and non-selective antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia. Synonyms: Ophtorenin; Bupranololum; Betadrenol; (S)-Bupranolol; 3-(tert-Butylamino)-1-(6-chloro-m-tolyloxy)-2-propanol; 2-Propanol, 1-(tert-butylamino)-3-(6-chloro-m-tolyloxy)-. Grade: 99%. CAS No. 14556-46-8. Molecular formula: C14H22ClNO2. Mole weight: 271.78. | |
| BUR1 | BUR1 is a cyclin-dependent kinase (CDK) of saccharomyces cerevisiae that is homologous to mammalian CDK9 and plays a role in transcriptional elongation. Synonyms: 1-Phenyl-4-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine, 1-phenyl-4-(1-piperidinyl)-; 1-Phenyl-4-(1-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine, 1-phenyl-4-piperidino-; 1-[1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]piperidine; BMP upregulator 1; BUR-1; BUR 1; BMP upregulator-1. Grade: ≥95%. CAS No. 23000-46-6. Molecular formula: C16H17N5. Mole weight: 279.34. | |
| Burapitant | Burapitant is a drug developed by Sanofi-Aventis which was one of the first compounds developed that acts as a potent and selective antagonist for the NK1 receptor. Synonyms: SSR240600; SSR-240600; SSR 240600; 1-[2-[(2R)-4-[2-[3,5-Bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-alpha,alpha-dimethyl-4-piperidineacetamide. Grade: >98%. CAS No. 537034-22-3. Molecular formula: C32H47N7O4. Mole weight: 682.53. | |
| Burixafor hydrobromide | Burixafor hydrobromide is an orally bioavailable and potent CXCR4 antagonist, which is a good antiangiogenic drug and has potential value in the treatment of choroidal neovascularization. Synonyms: TG-0054 hydrobromide; (2-{4-[6-Amino-2-({[4-({[3-(cyclohexylamino)propyl]amino}methyl)cyclohexyl]methyl}amino)-4-pyrimidinyl]-1-piperazinyl}ethyl)phosphonic acid hydrobromide (1:1); Phosphonic acid, [2-[4-[6-amino-2-[[[4-[[[3-(cyclohexylamino)propyl]amino]methyl]cyclohexyl]methyl]amino]-4-pyrimidinyl]-1-piperazinyl]ethyl]-, hydrobromide (1:1). Grade: ≥95%. CAS No. 1191450-19-7. Molecular formula: C27H52BrN8O3P. Mole weight: 647.63. | |
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