BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Brofaromine | Brofaromine is a short-acting specific type A monoamine oxidase inhibitor. Uses: Monoamine oxidase inhibitors. Synonyms: Brofarmine; Consonar; 4-(7-Bromo-5-methoxy-2-benzofuranyl)piperidine; CGP 11305A. Grade: 98%. CAS No. 63638-91-5. Molecular formula: C14H16BrNO2. Mole weight: 310.19. |  |
| Brofaromine Hydrochloride | Brofaromine Hydrochloride is a reversible inhibitor of monoamine oxidase A(RIMA). It acts on norepinephrine, epinephrine, serotonin and dopamine. It was mainly used in the treatment of depression and anxiety. It was developed by Novartis and was in clinic phase 3, but now it was terminated. Uses: Brofaromine hydrochloride was mainly used in the treatment of depression and anxiety. Synonyms: CGP-11305A HCl; CGP11305A HCl; Brofaromine HCl; 4-(7-Bromo-5-methoxy-2-benzofuranyl)piperidine hydrochloride; Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-, monohydrochloride. Grade: 98%. CAS No. 63638-90-4. Molecular formula: C14H17BrClNO2. Mole weight: 346.65. | |
| Broflanilide | Broflanilide, a GABA antagonist, is an insecticide that has high larvicidal activity against Spodoptera litura and is effective against pests with resistance to cyclodienes and fipronil. Synonyms: N-[2-Bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-2-fluoro-3-(N-methylbenzamido)benzamide; 3-(Benzoylmethylamino)-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide; 2-Fluoro-3-(N-methylbenzamido)-N-[2-bromo-4-(heptafluoroisopropyl)-6-(trifluoromethyl)phenyl]benzamide; 6'-Bromo-α,α,α,2-tetrafluoro-3-(N-methylbenzamido)-4'-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]benz-o-toluidide. Grade: ≥95%. CAS No. 1207727-04-5. Molecular formula: C25H14BrF11N2O2. Mole weight: 663.28. | |
| Brombuterol | Brombuterol is found to be a novel β-adrenergic agonist that can increase the meat-to-fat ratio but it is banned in animal feeds. Synonyms: 1-(4-Amino-3,5-dibromophenyl)-2-tert-butylaminoethanol. CAS No. 41937-02-4. Molecular formula: C12H18Br2N2O. Mole weight: 366.097. | |
| Brombuterol hydrochloride | Brombuterol hydrochloride is a salt form of Brombuterol, which is a β-adrenergic agonist. Synonyms: 1-(4-Amino-3,5-dibromophenyl)-2-tert-butylaminoethanol hydrochloride. CAS No. 21912-49-2. Molecular formula: C12H19Br2ClN2O. Mole weight: 402.55. | |
| Bromchlorbuterol hydrochloride | Bromchlorbuterol hydrochloride is a β-adrenergic receptor agonist. It has been used as an analytical standard. Synonyms: Bromoclenbuterol hydrochloride; 1-(4-amino-3-bromo-5-chlorophenyl)-2-(tert-butylamino)ethanol hydrochloride. CAS No. 78982-84-0. Molecular formula: C12H19BrCl2N2O. Mole weight: 358.11. | |
| Bromethalin | Bromethalin is a new rodenticide for the control of commensal rodents. Synonyms: Bromethalin; EL 614; EL-614; EL614. Grade: >98%. CAS No. 63333-35-7. Molecular formula: C14H7Br3F3N3O4. Mole weight: 577.93. | |
| Bromfenac-d4 sodium salt | Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2) with IC50 of 6.6 nM that is selective over COX-1 with IC50 of 210 nM. It inhibits prostaglandin E2 production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs. Bromfenac is a non-steroidal anti-inflammatory agent. Synonyms: Bromfenac-d4. Grade: ≥99% atom D. Molecular formula: C15H7BrD4NO3·Na. Mole weight: 360.17. | |
| Bromfenac Impurity (2-Amino-3-Benzoyl-alfa-Oxobenzeneacetic Sodium Salt) | Bromfenac Impurity (2-Amino-3-Benzoyl-alfa-Oxobenzeneacetic Sodium Salt) has anti-inflammatory activity. Synonyms: 2-Amino-3-benzoyl-α-oxo-benzeneacetic Acid Sodium Salt; 2-Amino-3-benzoyl-α-oxo-benzeneacetic Acid Monosodium Salt. Grade: > 95%. CAS No. 126849-31-8. Molecular formula: C15H10NO4Na. Mole weight: 291.24. | |
| Bromfenac Impurity (7-(4-bromobenzoyl)indoline-2,3-dione) | Bromfenac Impurity (7-(4-bromobenzoyl)indoline-2,3-dione) is a metabolite of Bromfenac sodium. Synonyms: AHR 11652. Grade: > 95%. CAS No. 241825-88-7. Molecular formula: C15H8BrNO3. Mole weight: 330.14. | |
| Bromfenac Lactam | Bromfenac Lactam is a cyclic metabolite of Bromfenac. Synonyms: 7-(4-Bromobenzoyl)-1,3-dihydro-2H-indol-2-one; AHR 10240. Grade: > 95%. CAS No. 91713-91-6. Molecular formula: C15H10BrNO2. Mole weight: 316.16. | |
| Bromfenac Sodium Salt | Bromfenac Sodium Salt is a potent inhibitor of both COX-1 and COX-2. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: AHR 10282R; AHR10282R; AHR-10282R. Grade: > 95%. CAS No. 91714-93-1. Molecular formula: C15H11BrNO3.Na. Mole weight: 356.15. | |
| Bromfenac Sodium Sesquihydrate | Bromfenac Sodium Sesquihydrate is the salt of Bromfenac, which is a NSAID that inhibits the activity of cyclooxygenase II (COX II) thus can be used to reduce inflammations. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: disodium 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate trihydrate. CAS No. 120638-55-3. Molecular formula: C30H28Br2N2Na2O9. Mole weight: 766.347. | |
| Bromhexine | Bromhexine is a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Synonyms: Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-; 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine; Toluene-α,2-diamine, 3,5-dibromo-Nα-cyclohexyl-Nα-methyl-; 2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine; Bromexine; Ezolvin; N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine; Na 274. Grade: 95%. CAS No. 3572-43-8. Molecular formula: C14H20N2Br2. Mole weight: 376.13. | |
| Bromhexine EP Impurity A | An impurity of Ambroxol and Bromhexine. Synonyms: 2-Amino-3,5-dibromo-benzenemethanol; Ambroxol EP Impurity A. Grade: > 95%. CAS No. 50739-76-9. Molecular formula: C7H7Br2NO. Mole weight: 280.95. | |
| Bromhexine EP Impurity B | An impurity of Ambroxol and Bromhexine. Synonyms: Ambroxol EP Impurity E. Grade: > 95 %. CAS No. 50910-55-9. Molecular formula: C7H5Br2NO. Mole weight: 278.93. | |
| Bromhexine Impurity C | Bromhexine Impurity C is an impurity of Bromhexine hydrochloride. Synonyms: N-(2-Aminobenzyl)-N-methylcyclohexanamine; 2-[(Cyclohexylmethylamino)methyl]phenylamine; 2-Amino-N-cyclohexyl-N-methylbenzenemethanamine; Nα-cyclohexyl-Nα- methyltoluene-α,2-diamine. Grade: > 95%. CAS No. 57365-08-9. Molecular formula: C14H22N2. Mole weight: 218.34. | |
| Bromhexine Impurity D | Bromhexine Impurity D is an impurity of Bromhexine, a drug predominantly dedicated to treating respiratory ailments. Grade: > 95%. CAS No. 132004-28-5. Molecular formula: C14H21BrN2. Mole weight: 297.24. | |
| Bromhexine Impurity (N-(2-Nitrobenzyl)-N-cyclohexyl-N-methylamine) | Bromhexine Impurity (N-(2-Nitrobenzyl)-N-cyclohexyl-N-methylamine) is an impurity of Bromhexine, a pharmaceutical agent employed in treating respiratory afflictions including bronchitand asthma. Synonyms: N-Cyclohexyl-N-methyl-2-nitrobenzenemethanamine; Einecs 279-522-8; N-(2-Nitrobenzyl)-N-methylcyclohexanamine. Grade: > 95%. CAS No. 80638-08-0. Molecular formula: C14H20N2O2. Mole weight: 248.33. | |
| Bromhexine Related Compound 2 HCl | An impurity of Bromhexine, a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. Synonyms: Bromhexine Related Compound 2 hydrochloride; 2-Amino-3-bromo-5-chloro-N-cyclohexyl-N-methylbenzenemethanamine. Grade: > 95%. CAS No. 32193-43-4. Molecular formula: C14H21BrCl2N2. Mole weight: 368.14. | |
| Bromindione | Bromindione, an inandione derivative, could be used as an orally bioavaliable anticoagulant. Uses: Bromindione could be used as an orally bioavaliable anticoagulant. Synonyms: Bromindione; 2-(4-Bromophenyl)-1H-indene-1,3(2H)-dione; 2-(4-Bromophenyl)-2,3-dihydro-1H-indene-1,3-dione; 2-(4-bromophenyl)indane-1,3-quinone; 2-(4-bromophenyl)indene-1,3-dione. Grade: 95%. CAS No. 1146-98-1. Molecular formula: C15H9BrO2. Mole weight: 301.13. | |
| Bromo 2,3,4,6-Tetra-O-acetyl-α-D-glucopyranoside-13C6 | Bromo 2,3,4,6-Tetra-O-acetyl-α-D-glucopyranoside-13C6 is an intermediate in synthesizing Aurothioglucose-13C6, a labelled analogue of Aurothioglucose, which is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-bromotetrahydro-2H-pyran-3,4,5-triyl-13C6 Triacetate. CAS No. 1173694-36-4. Molecular formula: C8[13C]6H19BrO9. Mole weight: 417.16. | |
| Bromo-2-tetraacetyl galactose | Bromo-2-tetraacetyl galactose is a profound compound extensively employed in the biomedical sector, serving as a precursor in antiviral research and development and its exploration in carbohydrate metabolism-related ailments render it invaluable. | |
| Bromoacetic acid-[d3] | Bromoacetic acid-[d3]. Synonyms: Bromoacetic acid-d3. Grade: 98% atom D. CAS No. 14341-48-1. Molecular formula: C2BrD3O2. Mole weight: 141.97. | |
| Bromobenzene-[d5] | Bromobenzene-[d5] can be used as a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents. Synonyms: Bromobenzene D5; Bromo(2H5)benzene; Pentadeuterobromobenzene. Grade: 99%. CAS No. 4165-57-5. Molecular formula: C6BrD5. Mole weight: 162.04. | |
| Bromo β-D-Cellotrioside Decaacetate | Bromo β-D-Cellotrioside Decaacetate is an intermediate in the synthesis of p-Nitrophenyl β-D-Cellotrioside. Molecular formula: C38H51BrO25. Mole weight: 987.71. | |
| Bromoconduritol | Bromoconduritol is a widely employed compound assuming a pivotal role in the intricate exploration and development of drugs targeting assorted ailments viz., diabetes, cancer and neurological disorders. Synonyms: 6-Bromo-3,4,5-trihydroxy cyclohex-1-ene; 6-Bromo-4-cyclohexene-1,2,3-triol. CAS No. 42014-74-4. Molecular formula: C6H9O3Br. Mole weight: 209.04. | |
| Bromocriptine | Bromocriptine, an ergoline derivative, is a dopamine agonist. It is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes. Synonyms: (5'-a2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3'; 2-bromo-alpha-ergocryptine; 2-bromo-alpha-ergokryptin; 2-bromo-alpha-ergokryptine; 2-bromoergocryptine; (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-ergotama. Grade: > 95%. CAS No. 25614-03-3. Molecular formula: C32H40BrN5O5. Mole weight: 654.61. | |
| Bromocriptine-13C-D3 Mesylate | One of the isotopic labelled form of Bromocriptine Mesylate, which has been found to be a dopamine receptor agonist. Synonyms: 2-Bromo α-Ergocryptine Mesylate 13C, D3. Grade: 95% by HPLC; 98% atom D/13C. Molecular formula: C32H37BrN5O5D3. Mole weight: 658.62. | |
| Bromocriptine Mesylate | Bromocriptine mesylate is the mesylate salt of Bromocriptine. It is a dopamine receptor agonist. It is a derivative of the ergotoxin group of ergot alkaloids. Uses: Antiparkinson agents. Synonyms: 2-Bromo α-Ergocryptine Mesylate; (5'α)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione Methanesulfonate; 2-Bromoergocryptine; Bagren; CB 154; Parlodel; Pravidel. Grade: 98%. CAS No. 22260-51-1. Molecular formula: C33H44BrN5O8S. Mole weight: 750.72. | |
| Bromodeoxyuridine (BrdU) | 5-Bromo-2'-deoxyuridine (5-BrdU) is a thymidine analog that can be incorporated into newly synthesized DNA to label it. Synonyms: 5-Bromo-2'-deoxyuridine; BrdU; Bromodeoxyuridine; Broxuridine; NSC 38297; 5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil; 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 5-Bromodeoxyuridine. Grade: ≥98% by HPLC. CAS No. 59-14-3. Molecular formula: C9H11BrN2O5. Mole weight: 307.10. | |
| Bromo Didehydro Doxorubicinone | Bromo Didehydro Doxorubicinone is an intermediate of Doxorubicin, which is an anthracycline antibiotic with anti-Gram-positive bacterial activity and a broad antitumor spectrum. Synonyms: 14-Brom-7-deoxydaunomycinon; 5,12-Naphthacenedione, 8-(bromoacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (R)-; (R)-8-(2-Bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; (R)-8-(Bromoacetyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; NSC 258818; (8R)-8-(Bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-tetracenedione. Grade: ≥95%. CAS No. 63626-06-2. Molecular formula: C21H17BrO7. Mole weight: 461.26. | |
| Bromodomain IN-1 | Bromodomain IN-1 is an inhibitor of Bromodomain. (Extracted from patent WO2016069578A1, compound 4). Synonyms: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 3-hydroxypropyl ester, (6S)-; 3-Hydroxypropyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate. Grade: ≥95%. CAS No. 1914120-48-1. Molecular formula: C22H23ClN4O3S. Mole weight: 458.96. | |
| Bromodomain inhibitor-8 | Bromodomain inhibitor-8 is a BET bromodomain inhibitor used for the treatment of autoimmune and inflammatory diseases. Synonyms: Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-, methyl ester; Methyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate. Grade: ≥98%. CAS No. 1300031-70-2. Molecular formula: C26H25ClN2O3. Mole weight: 448.94. | |
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grade: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| Bromoenol lactone-d7 | Bromoenol lactone-d7 (BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of BEL by GC- or LC-mass spectrometry (MS). BEL is a selective, potent, irreversible, mechanism-based inhibitor of phospholipase A2 (iPLA2) with a Ki value of 180 nM. It also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM). Synonyms: BEL-d7; Haloenol lactone-d7; HELSS-d7. Grade: ≥99% atom D. Molecular formula: C16H6D7BrO2. Mole weight: 324.2. | |
| Bromoiodoacetamide | Bromoiodoacetamide induces cytotoxicity by via reactive oxygen species (ROS) accumulation and apoptosis in HepG-2 cells. CAS No. 62872-36-0. Molecular formula: C2H3BrINO. Mole weight: 263.86. | |
| Bromo Prasugrel Impurity | An impurity of Prasugrel.Prasugrel is a platelet inhibitor. It can be used to prevent formation of blood clots. Grade: > 95%. Molecular formula: C20H19BrFNO3S. Mole weight: 452.35. | |
| Bromopride | Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic. Uses: A dopamine antagonist. Synonyms: Bromopride; VAL 13081; VA- 13081; VAL13081; 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid; 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-o-anisamid; 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; Artomey; Benzamide, 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-; Bromopr. Grade: ≥95%. CAS No. 4093-35-0. Molecular formula: C14H22BrN3O2. Mole weight: 344.25. | |
| Bromopride Impurity A | Bromopride Impurity A is an impurity of bromopride. Synonyms: N-Acetal Bromopride; 4-(Acetylamino)-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide. Grade: > 95%. CAS No. 94135-22-5. Molecular formula: C16H24BrN3O3. Mole weight: 386.29. | |
| Bromopride Impurity B | Methyl 4-Acetamido-5-bromo-2-methoxybenzoate is an impurity of bromopride, which is an antimetic. Synonyms: 4-Acetamido-5-bromo-o-anisic Acid Methyl Ester; 4-(Acetylamino)-5-bromo-2-methoxy-benzoic Acid Methyl Ester; Bromopride Impurity B. Grade: > 95%. CAS No. 4093-34-9. Molecular formula: C11H12BrNO4. Mole weight: 302.12. | |
| Bromopride Impurity C | Bromopride Impurity C is an impurity of bromopride. Synonyms: 4-Amino-5-bromo-2-methoxybenzenecarboxylic Acid; 2-Methoxy-4-amino-5-bromobenzoic Acid; 5-Bromo-4-amino-2-methoxybenzoic Acid; Benzoic Acid, 4-Amino-5-Bromo-2-Methoxy-; Oprea1_168799. Grade: > 95%. CAS No. 35290-97-2. Molecular formula: C8H8BrNO3. Mole weight: 246.06. | |
| Bromopropylate | Bromopropylate is a pesticide with moderate anti-androgenic activities. Synonyms: Isopropyl 4,4'-dibromobenzilate; Phenisobromolate; Isopropyl 2,2-bis(4-bromophenyl)-2-hydroxyacetate; Benzilic acid, 4,4'-dibromo-, isopropyl ester; Neoron. CAS No. 18181-80-1. Molecular formula: C17H16Br2O3. Mole weight: 428.12. | |
| Bromopyruvic acid | This active molecular is a synthetic brominated derivative of pyruvic acid which is a hexokinase II inhibitor and an effective antitumor agent because it is a highly reactive alkylating agent. The acute toxicity study provided an LD50 of 191.7 mg/kg for 3-BrPA in vivo. In 2010, Preclinical trials in Cancer in USA (Intra-arterial) for bromopyruvate was approved. In 2013, US FDA approved IND application for bromopyruvate in Liver cancer. Uses: Eliminating aggressive liver tumors. Synonyms: 3-bromo-2-oxopropanoic acid. Grade: 98 %. CAS No. 1113-59-3. Molecular formula: C3H3BrO3. Mole weight: 166.96. | |
| Bromosporine | Bromosporine, a broad spectrum inhibitor for bromodomains which play a key role in many cellular processes, is a chemical probe for bromodomain functional assays so that it is very helpful in elucidating further biological roles of reader domains. IC50: B. Synonyms: Bromosporine; 1619994-69-2; ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate; CHEMBL3133807; Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester; ethyl N-[6-(3-methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; ethyl N-[6-[3-(methanesulfonamido)-4-methylphenyl]-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate; Bromosporine?; GTPL8234; SCHEMBL17359131; Bromosporine, >=98% (HPLC); GLXC-04090; HMS3653C21; BDBM50504160; MFCD26142669; NSC768126; s7233; AKOS024458332; CCG-268692; CS-3240; NSC-768126; NCGC00351471-11; AS-75091; BB170570; BP-25350; DA-61904; HY-15815; SW219727-1; C73098; A904240; BRD-K44665581-001-01-8; Q27075529; ethyl (3-methyl-6-{4-methyl-3-[(methylsulfonyl)amino]phenyl}[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate. CAS No. 1619994-69-2. Molecular formula: C17H20N6O4S. Mole weight: 404.44. | |
| Bromoxynil 2,3,4-tri-O-acetyl-D-glucuronide methyl ester | Bromoxynil 2,3,4-tri-O-acetyl-D-glucuronide methyl ester is a specialized compound primarily employed in research of the metabolism and toxicity of Bromoxynil, a herbicide widely used in agriculture. It aids in elucidating the biological activities and potential therapeutic effects of Bromoxynil for studying various diseases, including herbicide poisoning or herbicide-induced toxicities. Molecular formula: C20H19Br2NO10. Mole weight: 593.17. | |
| Bromoxynil D-glucuronide methyl ester | Bromoxynil D-glucuronide methyl ester is a noteworthy compound, exhibiting its potential in research of herbicide toxicity arising from bromoxynil. Its role as a metabolite of bromoxynil crucially contributes to the detoxification process and enhances excretion capabilities. Molecular formula: C14H13Br2NO7. Mole weight: 467.06. | |
| Bromperidol | Bromperidol, a derivative of butyrophenone, is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the D2 dopamine and 5-HT2A serotonin receptor. Uses: Bromperidol is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the d2 dopamine and 5-ht2a serotonin receptor. Synonyms: 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; 4-[4-(p-Bromophenyl)-4-hydroxypiperidino]-4'-fluoro-butyrophenone; Azurene; Impromen; R 11333; R11333; R-11333; Tesoprel. Grade: 98%. CAS No. 10457-90-6. Molecular formula: C21H23BrFNO2. Mole weight: 420.32. | |
| brompheniramine | Brompheniramine an antihistamine drug.It belongs to the propylamine class. It can be used for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine also has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin and norepinephrine. Uses: The symptoms of the common cold and allergic rhinitis. Synonyms: 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine. Grade: 98%. CAS No. 86-22-6. Molecular formula: C16H19BrN2. Mole weight: 319.25. | |
| Brompheniramine hydrogen maleate | Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist. Grade: >98%. CAS No. 980-71-2. Molecular formula: C16H19BrN2·C4H4. Mole weight: 435.31. | |
| Brompheniramine maleate | Brompheniramine maleate. Synonyms: (±)-Brompheniramine maleate; Parabromdylamine maleate; Rolabromophen; Dimotane; Drauxin. Grade: 95%. CAS No. 32865-01-3. Molecular formula: C20H23BrN2O4. Mole weight: 435.31. | |
| Brompheniramine-N-oxide | Brompheniramine-N-oxide is an impurity of Brompheniramine, an H1 histamine receptor antagonist used to treat allergy symptoms such as sneezing, itching, or runny or stuffy nose. Synonyms: 3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine Oxide. CAS No. 18453-29-7. Molecular formula: C16H19BrN2O. Mole weight: 335.24. | |
| Brostallicin | Brostallicin, a-bromo-acrylamido tetra-pyrrole derivative, is a second-generation minor groove binder (MGB) structurally related to distamycin A with potential antineoplastic activity. Compared with that of other minor groove binders, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Synonyms: 4-[[4-[[4-[[4-(2-bromoprop-2-enoylamino)-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-N-[2-(diaminomethylideneamino)ethyl]-1-methylpyrrole-2-carboxamide; brostallicin; PNU 166196; PNU-166196; PNU166196. Grade: >98%. CAS No. 203258-60-0. Molecular formula: C30H36BrClN12O5. Mole weight: 723.58. | |
| Brostallicin hydrochloride | Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents. Synonyms: PNU-166196; PNU 166196; PNU166196; 4-(2-bromoacrylamido)-N-(5-(5-(5-(2-guanidinoethylcarbamoyl)-1-methyl- 1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H- pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide. CAS No. 203258-38-2. Molecular formula: C30H36BrClN12O5. Mole weight: 760.05. | |
| Brotianide | Brotianide, with anti-fasciolidal activity, is an anthelminthic drug for the treatment of severe infections on animals to remove larvae. Synonyms: [2-bromo-6-[(4-bromophenyl)carbamothioyl]-4-chlorophenyl] acetate; Brotianide; Dirian; Brotianidum [INN-Latin]; Brotianida [INN-Spanish]; UNII-30OGU6XH7S; Brotianide; Dirian; BAY-VA 4059; BAY-VA-4059; BAY-VA4059. Grade: >98%. CAS No. 23233-88-7. Molecular formula: C15H10Br2ClNO2S. Mole weight: 463.568. | |
| Broxyquinoline | Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes. Synonyms: broxyquinoline; 5,7-Dibromoquinolin-8-ol; 521-74-4; 5,7-Dibromo-8-hydroxyquinoline; 5,7-Dibromo-8-quinolinol; Dibromoxin; Broxyquinolin; Dibromoxine; Dibromoxyquinoline; Broxiquinoline; Dibromoquin; Fenilor; Broxykinolin; Dibromoksin; Paramiba; Brodiar; Colepur; Colipar; 5,7-Dibromooxine; Paramibe; 8-QUINOLINOL, 5,7-DIBROMO-; Broxichinolinum; Bromoxine; Starogyn; NSC 1810; NSC-1810; MFCD00006785. Grade: >98%. CAS No. 521-74-4. Molecular formula: C17H30N2O4. Mole weight: 326.4. | |
| BRP-201 | Brp-201 is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM. CAS No. 2227434-74-2. Molecular formula: C28H27ClN4OS. Mole weight: 503.06. | |
| BRP-7 | BRP-7 is a 5-LO activating protein (FLAP) inhibitor. Synonyms: BRP 7; BRP7. CAS No. 612046-20-5. Molecular formula: C26H27ClN2. Mole weight: 403. | |
| Br-PBTC | Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs. CAS No. 1839519-57-1. Molecular formula: C14H15BrN2OS. Mole weight: 339.25. | |
| Brr2-IN-3 | Brr2-IN-3 is an allosteric inhibitor of the spliceosomal RNA helicase Brr2, which is required for the activation of the spliceosome before the first catalytic step of RNA splicing. Synonyms: Brr2 Inhibitor C9; 6-Benzyl-3-(3-(thiazol-5-ylmethoxy)phenyl)-3,4-dihydropyrido[4,3-d]pyrimidine-2,7(1H,6H)-dione. CAS No. 2104030-82-0. Molecular formula: C24H20N4O3S. Mole weight: 444.51. | |
| Bryostatin 3 | Bryostatin 3 has been found to be a potent protein kinase C activator and could probably be useful in studies of emerging cancers. Synonyms: Bryostatin 3; 143370-84-7; (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester. Grade: ≥95% by HPLC. CAS No. 143370-84-7. Molecular formula: C46H64O17. Mole weight: 888.99. | |
| BS181 | BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50) of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L, with CDK2 being inhibited 35-fold less potently (IC(50) 880 nmol/L) than CDK7. In MCF-7 cells, BS-181 inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines, and showed antitumor effects in vivo. The drug was stable in vivo with a plasma elimination half-life in mice of 405 minutes after i.p. administration of 10 mg/kg. The same dose of drug inhibited the growth of MCF-7 human xenografts in nude mice. BS-181 therefore provides the first example of a potent and selective CDK7 inhibitor with potential as an anticancer agent. Synonyms: BS-181; BS181; BS 181. CAS No. 1092443-52-1. Molecular formula: C22H32N6. Mole weight: 380.53. | |
| BS 181 dihydrochloride | BS 181 dihydrochloride is a selective CDK7 inhibitor (IC50 = 21 nM) displaying >40-fold selectivity for CDK7 over others CDKs. BS 181 promotes cell cycle arrest and apoptosis in a range of cancer cells in MCF-7 cells and inhibits MCF-7 tumor xenograft growth in mice. Synonyms: BS 181 dihydrochloride; BS181 dihydrochloride; BS-181 dihydrochloride; N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride. Grade: ≥99% by HPLC. Molecular formula: C22H32N6.2HCl. Mole weight: 453.45. | |
| BS-181 dihydrochloride | BS-181 dihydrochloride is a potent and selective CDK7 inhibitor, with IC50s of 21, 880, 3000 and 4200 nM against CDK7, CDK2, CDK5 and CDK9 (fails to block CDK1, 4 and 6), respectively. It promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro, and inhibits the xenograft growth of MCF-7 tumors in mice. Synonyms: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine Dihydrochloride; N5-(6-Aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride; Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-, hydrochloride (1:2). Grade: ≥95%. CAS No. 1883548-83-1. Molecular formula: C22H34Cl2N6. Mole weight: 453.45. | |
| BS-181 HCl | BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Synonyms: BS-181 HCl; BS 181 HCl; BS181 HCl. Grade: >98%. CAS No. 1397219-81-6. Molecular formula: C22H32N6.HCl. Mole weight: 416.99. | |
| BSc2118 | BSc2118 is a potent proteasome inhibitor. BSc2118 shows significant antimyeloma activity and may be considered as a promising agent in cancer drug development. BSc2118 is also a promising new candidate for stroke therapy, which may in addition alleviate recombinant tissue-plasminogen activator-induced brain toxicity. Synonyms: BSc-2118; BSc 2118. Grade: 98%. CAS No. 863924-64-5. Molecular formula: C28H43N3O7. Mole weight: 533.66. | |
| BSc5371 | BSc5371 is a potent and irreversible inhibitor of FLT3, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. It is cytotoxic to FLT3-dependent cell lines. Synonyms: N-[2-(Diethylamino)ethyl]-2,4-dimethyl-5-[(Z)-{2-oxo-5-[(vinylsulfonyl)amino]-1,2-dihydro-3H-indol-3-ylidene}methyl]-1H-pyrrole-3-carboxamide; 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-[5-[(ethenylsulfonyl)amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-. Grade: ≥95%. CAS No. 2286419-03-0. Molecular formula: C24H31N5O4S. Mole weight: 485.60. | |
| BSH-IN-1 | BSH-IN-1 is a covalent inhibitor of bile salt hydrolases. BSH-IN-1 inhibits the bile salt hydrolases of the Gram-negative bacterium B. theta and the Gram-positive bacterium B. longum (IC50s = 427 and 108 nM, respectively). It also inhibits deconjugation of bile acids in a variety of bacteria and in resuspended mouse feces. Synonyms: (R)-5-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-fluorohexan-2-one. Grade: ≥98%. CAS No. 2553217-91-5. Molecular formula: C25H41FO3. Mole weight: 408.59. | |
| b-Sitosterol b-D-glucuronide methyl ester | b-Sitosterol b-D-glucuronide methyl ester is a notable biomedical compound with potent anticancer attributes. Also, it exhibits insulin sensitivity in the realm of diabetes research. Molecular formula: C36H60O7. Mole weight: 604.86. | |
| BSJ-01-175 | Bsj-01-175, a potent and selective covalent inhibitor of CDK12/13, shows exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells. Synonyms: 2-Butenamide, N-[4-[[(1R,3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]cyclohexyl]oxy]phenyl]-4-(dimethylamino)-, (2E)-. CAS No. 2227392-55-2. Molecular formula: C30H33ClN6O2. Mole weight: 545.08. | |
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