BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BRD7552 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Synonyms: BRD-7552; BRD 7552; BRD7552. Grade: 95%. CAS No. 1137359-47-7. Molecular formula: C33H33N3O15. Mole weight: 711.63. |  |
| BRD7-IN-1 | BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) and binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one dihydrochloride; 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-, hydrochloride (1:2). Grade: ≥95%. CAS No. 2448414-48-8. Molecular formula: C22H28Cl2N4O3. Mole weight: 467.39. | |
| BRD7-IN-1 free base | BRD7-IN-1 free base is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-; 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one. Grade: ≥95%. CAS No. 2305379-66-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| BRD9539 | BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) with an IC50 value of 6.3 μM. It is selective for G9a and PRC2 over SU39H1 and NDMT1 up to a concentration of 40 μM. BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. Synonyms: BRD-9539; BRD 9539. Grade: ≥98%. CAS No. 1374601-41-8. Molecular formula: C24H21N3O3. Mole weight: 399.4. | |
| BRD 9757 | BRD9757 is a potent and selective histone deacetylases 6 (HDAC6) inhibitor with IC50 of 30 nM. It displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold). Synonyms: N-Hydroxy-1-cyclopentene-1-carboxamide; BRD9757; BRD-9757. Grade: ≥98%. CAS No. 1423058-85-8. Molecular formula: C6H9NO2. Mole weight: 127.14. | |
| BRD 9876 | BRD 9876 is an ATP non-competitive kinesin Eg5 inhibitor. It selectively inhibits microtubule-bound Eg5 leading to an arrest in G2/M phase. Synonyms: BRD9876; BRD-9876; BRD 9876; 6-(1,1-Dimethylethyl)-2,3-naphthalenedicarbonitrile; 6-Tert-Butyl-2,3-naphthalenedicarbonitrile. Grade: ≥99% by HPLC. CAS No. 32703-82-5. Molecular formula: C16H14N2. Mole weight: 234.3. | |
| BRD-IN-3 | BRD-IN-3, a highly potent inhibitor of PCAF bromodomain (BRD) (IC50 = 7 nM), has activity against GCN5 and FALZ. Synonyms: (R,R)-36n; 2-(((3R,5R)-5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-methylpiperidin-3-yl)amino)-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-[[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-3-piperidinyl]amino]-3,5-dihydro-3-methyl-; 2-{[(3R,5R)-5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-methyl-3-piperidinyl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one. Grade: ≥95%. CAS No. 2351938-32-2. Molecular formula: C21H25N5O3. Mole weight: 395.45. | |
| BRD-K98645985 | BRD-K98645985 is a BAF inhibitor that binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity. Synonyms: BRD K98645985; BRDK98645985; 1-Isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1,4,9]oxadiazacyclododecin-12-yl)urea. Grade: >98%. CAS No. 1357647-78-9. Molecular formula: C33H43N5O4. Mole weight: 573.73. | |
| Brecanavir | Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Uses: Hiv-1 protease inhibitor. Synonyms: Brecanavir; UNII-E367I8C7FI; CHEMBL206031; GW-0385; GW-640385; GW-640385X; VX-385; GW0385; GW640385; GW640385X; VX385; GW 0385; GW 640385; GW 640385X; VX 385; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Grade: ≥98%. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. | |
| Brentuximab | Brentuximab is a chimeric antibody directed against CD30, a protein often found at high levels on classical Hodgkin lymphoma cells (called Reed-Sternberg cells). CAS No. 2088770-90-3. | |
| Brequinar | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grade: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. | |
| Brequinar sodium | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grade: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
| Bretylium | Bretylium, a class III antiarrhythmic agent, is an inhibitor of the presynaptic release of vasoconstrictive neurotransmitters and a blocker of sympathetic and adrenergic nerves. Uses: Anti-arrhythmia agents. Synonyms: 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium; (o-Bromobenzyl)ethyldimethylammonium; Bretylan; Bretylate; Bretylol; N-Ethyl-N-(o-bromobenzyl)-N,N-dimethylammonium; NSC62164; Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-. Grade: 95%. CAS No. 59-41-6. Molecular formula: C11H17BrN+. Mole weight: 243.16. | |
| Bretylium Tosylate | Bretylium Tosylate, a class III antiarrhythmic agent, is an inhibitor of the presynaptic release of vasoconstrictive neurotransmitters and a blocker of sympathetic and adrenergic nerves. Synonyms: 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-Methylbenzenesulfonate; (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate; (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate; ASL 603; Bretylan; Bretylate; Bretylium p-Toluenesulfonate; Bretylium Tosilate; Bretylol; Darenthin; N-Ethyl-N-(o-bromobenzyl)-N,N-dimethylammonium Tosylate; NSC 62164; Ornid. Grade: ≥95%. CAS No. 61-75-6. Molecular formula: C18H24BrNO3S. Mole weight: 414.36. | |
| Brevetoxin PbTx-9 | An activator of voltage-sensitive Na+ channels, a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis. A ciguatoxin comprising a linear sequence of ten trans-fused five-, six-, eight- and nine-membered rings. Synonyms: Brevetoxin B, 42-deoxo-41,43-dihydro-42-hydroxy-. Grade: 95 % (HPLC). CAS No. 142353-09-1. Molecular formula: C50H74O14. Mole weight: 899.12. | |
| Brexpiprazole | Brexpiprazole is a novel atypical antipsychotic drug. It is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). It is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders. Uses: Brexpiprazole is approved for the treatment of schizophrenia, and as an adjunctive treatment for depression. it is a drug candidate useful in treatment and prevention of mental disorders including cns disorders. Synonyms: 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one; OPC 34712. Grade: > 95%. CAS No. 913611-97-9. Molecular formula: C25H27N3O2S. Mole weight: 433.58. | |
| Brexpiprazole dihydrochloride | The hydrochloride salt form of Brexpiprazole, whihch is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). Brexpiprazole exhibits high affinity for h5-HT1A (partial agonist), h5-HT2A (antagonist), hD2L (partial agonist), hα1B (antagonist) and hα2C-adrenergic (antagonist) receptors (Ki values <1 nM). Synonyms: OPC 34712 dihydrochloride; 7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride. Grade: 98%. CAS No. 2512192-75-3. Molecular formula: C25H27N3O2S.2HCl. Mole weight: 506.49. | |
| Brexpiprazole hydrochloride | The hydrochloride salt form of Brexpiprazole, whihch is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). Brexpiprazole exhibits high affinity for h5-HT1A (partial agonist), h5-HT2A (antagonist), hD2L (partial agonist), hα1B (antagonist) and hα2C-adrenergic (antagonist) receptors (Ki values <1 nM). Synonyms: 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]-2(1H)-Quinolinone hydrochloride; 7-[4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one hydrochloride. Grade: 98%. CAS No. 913612-38-1. Molecular formula: C25H27N3O2S.xHCl. Mole weight: 433.58 (free base). | |
| Brexpiprazole Impurity 10 | Brexpiprazole Impurity 10 is an impurity of Brexpiprazole, a drug used to counter psychiatric afflictions such as schizophrenia and major depressive disorder. Synonyms: m-Cinnamanisidide; N-(3-Methoxyphenyl)-3-phenylpropenamide. Grade: > 95%. CAS No. 15116-41-3. Molecular formula: C16H15NO2. Mole weight: 253.30. | |
| Brexpiprazole Impurity 9 | Brexpiprazole Impurity 9 is an impurity of brexpiprazole and related pharmaceutical formulations. Brexpiprazole is a medication utilized to treat schizophrenia and major depressive disorder. Synonyms: 5-Hydroxyquinolin-2(1H)-one; 5-Hydroxy-2(1H)-quinolone; 5-Hydroxycarbostyril; NSC 134652. Grade: > 95%. CAS No. 31570-97-5. Molecular formula: C9H7NO2. Mole weight: 161.16. | |
| Brexpiprazole S-oxide | Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor. Synonyms: DM-3411; 7-[4-[4-(1-Oxidobenzo[b]thien-4-yl)-1-piperazinyl]butoxy]-2(1H)-quinolinone; 4-(4-{4-[(2-Oxo-1,2-dihydro-7-quinolinyl)oxy]butyl}-1-piperazinyl)-1-benzothiophenium-1-olate. Grade: ≥95%. CAS No. 1191900-51-2. Molecular formula: C25H27N3O3S. Mole weight: 449.57. | |
| Briakinumab | Briakinumab is a human anti-IL-12 monoclonal antibody developed for the treatment of rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Crohn's Disease. Synonyms: ABT-874; ABT 874; ABT874. Grade: 95%. CAS No. 339308-60-0. Molecular formula: C6376H9874N1722O1992S44. Mole weight: 143.9 kDa. | |
| Brialmontin 1 | Brialmontin 1 is a highly efficacious compound employed in the research of diverse cancer forms, encompassing breast, lung and colon malignancies manifesting remarkable anticancer potential through precise engagement with distinct molecular cascades, consequently studying malignant cell proliferation. Synonyms: NSC-646005. CAS No. 128585-08-0. Molecular formula: C22H28O5. Mole weight: 372.45. | |
| Brialmontin 2 | Brialmontin 2 is an avant-garde biomedical innovation, meticulously aims at studying and remedying intricate bacterial infections. CAS No. 128585-09-1. Molecular formula: C21H26O5. Mole weight: 358.43. | |
| Briciclib | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. It is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. It may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. It inhibits the proliferation of MCL, gastric, breast and esophageal cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM) in vitro. It binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins and leads to tumor cell death in vitro. It is active in nonclinical tumor models when combined with several chemotherapeutics. Uses: Briciclib may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. it is active in nonclinical tumor models when combined with several chemotherapeutics. Synonyms: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate); ON-014185; (E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate; [2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate. Grade: >98 %. CAS No. 865783-99-9. Molecular formula: C19H23O10PS. Mole weight: 474.42. | |
| Briciclib sodium | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. Synonyms: ON-013105; ON013105; ON 013105; ON 014185; ON014185; ON-014185. Grade: >98%. CAS No. 865784-01-6. Molecular formula: C19H21Na2O10PS. Mole weight: 518.38. | |
| Brigatinib | Brigatinib, also known as AP-26113, is an orally active, potent and selective dual ALK/EGFR inhibitor. AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 < 100 nM in Ba/F3 cells). AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. It blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. Synonyms: AP26113. Grade: ≥98%. CAS No. 1197953-54-0. Molecular formula: C29H39ClN7O2P. Mole weight: 584.10. | |
| Brilacidin tetrahydrochloride | Brilacidin Tetrahydrochloride is a defensin mimetic. Brilacidin tetrahydrochloride is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Uses: Anti-infective agents. Synonyms: Brilacidin (tetrahydrochloride); PMX 30063 tetrahydrochloride; N4,N6-Bis[3-[[5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-2-[(3R)-3-pyrrolidinyloxy]-5-(trifluoromethyl)phenyl]-4,6-pyrimidinedicarboxamide Hydrochloride. Grade: 99%. CAS No. 1224095-99-1. Molecular formula: C40H54Cl4F6N14O6. Mole weight: 1082.75. | |
| Brilaroxazine | Brilaroxazine acts as an antipsychotic which may be effective in the treatment of schizophrenia and bipolar disorder. It is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Synonyms: 2H-1,4-Benzoxazin-3(4H)-one, 6-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-; RP-5063. Grade: 98%. CAS No. 1239729-06-6. Molecular formula: C22H25Cl2N3O3. Mole weight: 450.36. | |
| Brilliant black | Brilliant black BN, an azo dye and a food colorant, is a promising antiviral drug against EV71 infection by inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. Synonyms: Black PN; Brilliant Black BN; Food black 1; Blue Black BN; Brilliant Black A; Melan Black; Cilefa Black B; 1,7-Naphthalenedisulfonic acid, 4-(acetylamino)-5-hydroxy-6-[2-[7-sulfo-4-[2-(4-sulfophenyl)diazenyl]-1-naphthalenyl]diazenyl]-, sodium salt (1:4). Grade: Dye content >60%. CAS No. 2519-30-4. Molecular formula: C28H17N5Na4O14S4. Mole weight: 867.68. | |
| Brilliant Blue G | Brilliant Blue G is a dye which is commonly used in laboratories to stain or quantify proteins. It can act as a selective inhibitor of the P2X purinoceptor channel P2X7 (IC50s = 10.1 and 265 nM for rat and human P2X7, respectively). A variety of methods have been developed for using Brilliant Blue G to stain gels with ease and sensitivity. Synonyms: Acid Blue 90; CBBG; Coomassie Brilliant Blue G-250; NSC 328382. Grade: ≥98%. CAS No. 6104-58-1. Molecular formula: C47H48N3O7S2·Na. Mole weight: 832.04. | |
| Brimonidine | Brimonidine is α2-Adrenoceptor agonist. It is a drug used as eye drops to treat open-angle glaucoma or ocular hypertension. It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow. Uses: Α2-adrenoceptor agonist. antiglaucoma. Synonyms: UK 14,304; UK14,304; UK-14,304; UK14304; Brimonidine; AGN 190342; AGN-190342; AGN1903425-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)-6-quinoxalinamin. Grade: ≥95%. CAS No. 59803-98-4. Molecular formula: C11H10BrN5. Mole weight: 292.13. | |
| Brimonidine-d4 | Brimonidine-d4 is a labelled Brimonidine. Brimonidine is a medication used to treat open-angle glaucoma or ocular hypertension. Synonyms: 5-Bromo-N-(4,5-dihydro-1H-imidazol-d4-2-yl)-6-quinoxalinamine; 5-Bromo-6-(2-imidazolin-d4-2-ylamino)quinoxaline; AGN-190342-d4; UK-14304-d4. Grade: > 95%. CAS No. 1184971-51-4. Molecular formula: C11H6D4BrN5. Mole weight: 296.18. | |
| Brimonidine EP Impurity E | Brimonidine EP Impurity E is an impurity of Brimonidine, a medication used to lower pressure in the eyes in patients who have glaucoma. Synonyms: N-(5-Bromo-6-quinoxalinyl)guanidine; 1-(5-Bromoquinoxalin-6-yl)guanidine. CAS No. 168329-48-4. Molecular formula: C9H8BrN5. Mole weight: 266.10. | |
| Brimonidine Impurity H | Brimonidine Impurity H is structurally related to Brimonidine. Synonyms: UK 14819; 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine. Grade: > 95%. CAS No. 91147-46-5. Molecular formula: C11H10ClN5. Mole weight: 247.69. | |
| Brimonidine Impurity I | Brimonidine Impurity I is an impurity of the antiglaucoma drug, Brimonidine. Synonyms: 5-Bromoquinazolin-6-ylthiourea; N-(5-bromo-6-quinoxalinyl)thioure; Thiourea,N-(5-broMo-6-quinoxalinyl)-; (5-Bromo-6-quinoxalinyl)thiourea. Grade: > 95%. CAS No. 842138-74-3. Molecular formula: C9H7BrN4S. Mole weight: 283.15. | |
| Brimonidine impurity II | Brimonidine impurity II is an analogue of Brimonidine. Synonyms: N-(4,5-Dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; UK 41511. Grade: > 95%. CAS No. 91147-43-2. Molecular formula: C11H11N5. Mole weight: 213.24. | |
| Brimonidine Related Compound (5-Bromo-6-Aminoquinoxaline) | Brimonidine Related Compound (5-Bromo-6-Aminoquinoxaline) is a metabolite of Brimonidine. Synonyms: 6-Amino-5-bromoquinoxaline; 5-Bromoquinoxalin-6-amine. Grade: > 95%. CAS No. 50358-63-9. Molecular formula: C8H6BrN3. Mole weight: 224.06. | |
| Brimonidine Related Impurity 2 | Brimonidine Related Impurity 2 is a brimonidine impurity. Synonyms: 4,5-Didehydro Brimonidine; 5-Bromo-N-1H-imidazol-2-yl-6-quinoxalinamine; Brimonidine EP Imprurity F. Grade: > 95%. CAS No. 151110-15-5. Molecular formula: C11H8BrN5. Mole weight: 290.12. | |
| Brimonidine Related Impurity 3 | Brimonidine Related Impurity 3 is a useful synthetic intermediate in the synthesis of Brimonidine. Synonyms: Quinoxaline 6-Isothiocyanate; 6-Isothiocyanatoquinoxaline. Grade: > 95%. CAS No. 135306-56-8. Molecular formula: C9H5N3S. Mole weight: 187.22. | |
| Brimonidine Tartrate | Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension. Synonyms: Brimonidine L-Tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-Tartrate; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UK-14304-18; AGN-190342-LF. Grade: >98%. CAS No. 70359-46-5. Molecular formula: C15H16BrN5O6. Mole weight: 442.22. | |
| Brimonidine Tartrate Impurity 1 | Brimonidine Tartrate Impurity 1 is a metabolite of Brimonidine. Synonyms: Brimonidine-2,3-dione; 5-Bromo-6-[(4,5-dihydro-1H-imidazol-2-yl)amino]-1,4-dihydro-2,3-quinoxalinedione. Grade: > 95%. CAS No. 182627-95-8. Molecular formula: C11H10BrN5O2. Mole weight: 324.14. | |
| Brinzolamide hydrochloride | Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM. Synonyms: (4R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide Hydrochloride; AL-4682 Hydrochloride; Azopt Hydrochloride. CAS No. 150937-43-2. Molecular formula: C12H22ClN3O5S3. Mole weight: 419.97. | |
| Brinzolamide maleate | A maleate salt of Brinzolamide. Brinzolamide is a potent carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Synonyms: Brinzolamide maleic acid adduct; 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-, (2Z)-2-butenedioate (1:1); (R)-4-(Ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide maleate. Grade: ≥95%. CAS No. 1448780-04-8. Molecular formula: C12H21N3O5S3.C4H4O4. Mole weight: 499.58. | |
| Brinzolamide Related Compound B | Brinzolamide Related Compound B is Brinzolamide derivative. Synonyms: (4R)-4-Amino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; AL 8520; N-Desethyl Brinzolamide. Grade: > 95%. CAS No. 404034-55-5. Molecular formula: C10H17N3O5S3. Mole weight: 355.46. | |
| Brinzolamide Related Compound C | Brinzolamide Related Compound C is an isomer of Brinzolamide. Synonyms: (S)-Brinzolamide; (S)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; AL 4862. Grade: > 95%. CAS No. 154127-19-2. Molecular formula: C12H21N3O5S3. Mole weight: 383.51. | |
| BRITE 338733 | BRITE 338733 is a novel ATPase inhibitor. BRITE 338733 inhibits the expression of RecA in bacteria (IC50 = 4.7 μM) for the treatment of bacterial infections. Uses: A novel atpase inhibitor for the treatment of bacterial infections. Synonyms: BCP0008025; BRITE338733; BCP 0008025; BRITE 338733; BCP-0008025; BRITE-338733; 2-(4-(5-ethylfuran-2-yl)-6-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyridin-2-yl)-4-methylphenol; 2-(6-(2,2,6,6-tetramethylpiperidin-4-ylamino)-4-(5-ethylfuran-2-yl)pyridin-2-yl)-4-methylphenol. Grade: ≥98%. CAS No. 503105-88-2. Molecular formula: C27H35O2N3. Mole weight: 433.59. | |
| Brivanib | Brivanib is the hydrolyzed form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Synonyms: BMS540215; BMS-540215; BMS 540215. CAS No. 649735-46-6. Molecular formula: C19H19FN4O3. Mole weight: 370.37756. | |
| Brivanib alaninate | Brivanib alaninate is the alaninate ester of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Synonyms: BMS-582664; BMS582664; BMS 582664. CAS No. 649735-63-7. Molecular formula: C22H24FN5O4. Mole weight: 441.45. | |
| Brivudine | Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro. Synonyms: (E)-5-(2-Bromovinyl)-2'-deoxyuridine; (E)-5-(2-Bromovinyl)deoxyuridine; (E)-5-O-(2-bromoethenyl)-2'-deoxyuridine; 5-[(1E)-2-Bromoethenyl]-2'-deoxyuridine; 5-[(E)-2-Bromoethenyl]-2'-deoxyuridine; BVDU; Brivudin; Bromovinyldeoxyuridine; Helpin. Grade: ≥98% by HPLC. CAS No. 69304-47-8. Molecular formula: C11H13BrN2O5. Mole weight: 333.14. | |
| Brivudine 5'-Diphosphate Tristriethyl Ammonium Salt | Brivudine 5'-Diphosphate Tristriethyl Ammonium Salt is derived from Brivudine, which is a nucleoside analog which causes induction of neuronal differentiation in human reporter cell lines and adult stem cells. Anti-Herpes medication. Molecular formula: C11H15BrN2O11P2 C6H15N. Mole weight: 493.10. | |
| Brivudine 5'-Monophosphate | Brivudine 5'-Monophosphate is a hetero-dinucleotide that acts as an anti-tumor agent against AH13 rat sarcoma cells. A nucleotide derivative which is an active species of the novel anticancer drug, NB 1011. Anti-viral. Synonyms: BVDU 5'-Monophosphate; (E)-5-(2-Bromovinyl)-2'-deoxyuridine 5'-Monophosphate; 5-[(1E)-2-Bromoethenyl]-2'-deoxy-5'-uridylic Acid; (E)-5-(2-bromoethenyl)-2'-deoxy-5'-uridylic Acid. CAS No. 80860-82-8. Molecular formula: C11H14BrN2O8P. Mole weight: 413.12. | |
| Brivudine 5'-Triphosphate Ammonium | Brivudine 5'-Triphosphate Ammonium Salt is derived from Brivudine, which is a nucleoside analog which causes induction of neuronal differentiation in human reporter cell lines and adult stem cells. Anti-herpes medication. Synonyms: 5-(2-Bromovinyl)-2'-deoxyuridine-5'-triphosphate; [[(2R,3S,5R)-5-[5-[(E)-2-bromoethenyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate; Uridine 5'-(tetrahydrogen triphosphate), 5-(2-bromoethenyl)-2'-deoxy-, (E)-; BVdUTP; BV(5)Dutp; Bvdu-tp; SCHEMBL442341; SCHEMBL442343; CHEMBL4594370; (E)-5-(2-Bromovinyl)-dUTP; Brivudine 5'-Triphosphate Ammonium; E-5-Bromovinyl-2'-deoxyuridine triphosphate; (E)-5-(2-Bromovinyl)-2'-deoxyuridine triphosphate; (e)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate; Uridine 5'-(tetrahydrogen triphosphate), 5-[(1E)-2-bromoethenyl]-2'-deoxy-; ((2R,3S,5R)-5-(5-((E)-2-Bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; [[(2R,3S,5R)-5-[5-[(E)-2-bromovinyl]-2,4-dioxo-pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate. Molecular formula: C11H16BrN2O14P3. Mole weight: 573.08. | |
| Brivudine Impurity ((E)-5-(2-Bromovinyl)uracil ) | Brivudine Impurity ((E)-5-(2-Bromovinyl)uracil) is an impurity commonly found in Brivudine. Brivudine is an antiviral drug used to treat herpes zoster (shingles) and genital herpes. Synonyms: 5-[(1E)-2-Bromoethenyl]-2,4(1H,3H)-pyrimidinedione. Grade: > 95%. CAS No. 69304-49-0. Molecular formula: C6H5BrN2O2. Mole weight: 217.02. | |
| BRL 15572 | BRL-15,572 is selective 5-HT1D antagonist with around 60x selectivity over other related receptors. It is a useful tool for the differentiation between human 5-HT1B and 5-HT1D receptors in functional studies. Uses: Serotonin 5-ht1 receptor antagonists. Synonyms: RL 15572; RL15572; RL-15572; 1-(Diphenylmethyl)-2-(4-(3-chlorophenyl)-1-piperazinyl)ethanol; 193611-72-2 (HCl). Grade: 98%. CAS No. 734517-40-9. Molecular formula: C25H27ClN2O. Mole weight: 406.95. | |
| BRL-15572 dihydrochloride | BRL-15572 displays high affinity and selectivity for h5-HT1D receptors. BRL-15572 has 60-fold higher affinity for h5-HT1D than 5-HT1B receptors. Uses: Serotonin 5-ht1 receptor antagonists. Synonyms: BRL-15572; BRL 15572; BRL15572. Grade: >98%. CAS No. 193611-72-2. Molecular formula: C25H27ClN2O.2HCl. Mole weight: 479.87. | |
| BRL 15572 hydrochloride | BRL 15572 hydrochloride is a selective h5-HT1D antagonist with 60-fold selectivity over h5-HT1B. Synonyms: BRL 15572 hydrochloride; BRL15572 hydrochloride; BRL-15572 hydrochloride; 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochloride. CAS No. 1173022-77-9. Molecular formula: C25H27ClN2O.HCl. Mole weight: 443.42. | |
| BRL-37344 | BRL-37344 is a new, highly specific, beta 3-adrenergic receptor radioligand. Synonyms: 2-(4-((2R)-2-(((2R)-2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetic acid; SB-206606; BRL 37344. CAS No. 114333-71-0. Molecular formula: C19H22ClNO4. Mole weight: 363.84. | |
| BRL-37344 sodium | BRL37344 is a selective β3-adrenergic receptor agonist originated by GlaxoSmithKline. Ki value is 287nM for β3 receptor, 1750nM for β1 receptor and 1120nM for β2 receptor. BRL37344 can decrease nerve-evoked contractions in human detrusor smooth muscle isolated strips, it can also stimulate fuel oxidation by soleus muscle in vitro. BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin. But preclinical for Diabetes mellitus was discontinued. Uses: Diabetes mellitus. Synonyms: BRL-37344 sodium; BRL 37344 sodium; BRL37344 sodium; sodium; 2-[4-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetate. Grade: 98 %. CAS No. 127299-93-8. Molecular formula: C19H21ClNNaO4. Mole weight: 385.82. | |
| BRL44385 | BRL44385, a novel guanine analogue, is a potent and selective inhibitor of herpes simplex virus types 1 and 2 and varicella zoster virus. Synonyms: 2-amino-9-(3-hydroxypropoxy)-3H-purin-6-one; 9-(3-hydroxypropoxy)guanine; BRL 44385; BRL-44385. Grade: >98%. CAS No. 114778-60-8. Molecular formula: C8H11N5O3. Mole weight: 225.2. | |
| BRL 44408 | BRL 44408 is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors, respectively). BRL 44408 increases hippocampal noradrenalin release following systemic administration. Uses: Selective α2a-adrenoceptor antagonist. increases hippocampal noradrenaline release following systemic administration. Synonyms: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole; 1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-. Grade: ≥95%. CAS No. 118343-19-4. Molecular formula: C17H21N3O4. Mole weight: 331.37. | |
| BRL 44408 Maleate | BRL 44408 maleate is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors, respectively). BRL 44408 increases hippocampal noradrenalin release following systemic administration. Synonyms: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate; 1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-, (2Z)-2-butenedioate (1:1). Grade: ≥98% by HPLC. CAS No. 681806-46-2. Molecular formula: C17H21N3O4. Mole weight: 331.37. | |
| BRL 50481 | BRL 50481 is a potent, selective substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Uses: A pde7 inhibitor that has acceptable selectivity for in vivo studies. Synonyms: BRL-50481; BRL 50481; BRL50481. 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene, 5-Nitro-2-N,N-trimethylbenzenesulfonamide. Grade: ≥95%. CAS No. 433695-36-4. Molecular formula: C9H12N2O4S. Mole weight: 244.27. | |
| BRL 52537 | BRL 52537 is a potent and highly selective KOR-1 (κ-opioid receptor) and MOR (μ-opioid receptor) agonist with analgesic effects. Synonyms: Ethanone, 2-(3,4-dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]-; 2-(3,4-Dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]ethanone; Piperidine, 1-[(3,4-dichlorophenyl)acetyl]-2-(1-pyrrolidinylmethyl)-; Piperidine, 1-[(3,4-dichlorophenyl)acetyl]-2-(1-pyrrolidinylmethyl)-, (±)-; 2-(3,4-dichlorophenyl)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)ethan-1-one; BRL52537; BRL-52537. Grade: ≥95%. CAS No. 130497-33-5. Molecular formula: C18H24Cl2N2O. Mole weight: 355.30. | |
| BRL 52537 hydrochloride | BRL 52537 hydrochloride is a potent and highly selective KOR-1 (κ-opioid receptor) and MOR (μ-opioid receptor) agonist with analgesic effects. Synonyms: BRL52537 hydrochloride; BRL-52537 hydrochloride; (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride; Ethanone, 2-(3,4-dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]-, hydrochloride (1:1); Piperidine, 1-[(3,4-dichlorophenyl)acetyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride; Piperidine, 1-[(3,4-dichlorophenyl)acetyl]-2-(1-pyrrolidinylmethyl)-, monohydrochloride, (±)-; BRL 52537 monohydrochloride. Grade: ≥98% by HPLC. CAS No. 112282-24-3. Molecular formula: C18H24Cl2N2O.HCl. Mole weight: 391.77. | |
| BRL-54443 | BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. Synonyms: BRL54443; BRL-54443; BRL 54443. Grade: >98%. CAS No. 57477-39-1. Molecular formula: C14H18N2O. Mole weight: 230.31. | |
| BRM/BRG1 ATP Inhibitor-1 | BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, with IC50s of <0.005 μM. Synonyms: 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea; Dual BRM and BRG1 inhibitor 14. Grade: ≥98%. CAS No. 2270879-17-7. Molecular formula: C11H9F3N4O2S. Mole weight: 318.27. | |
| BRN-103 | BRN-103 can suppress the phosphorylation of vascular endothelial growth factor (VEGF) receptor 2. It can also inhibit the activations of AKT and eNOS. These results show that BRN-103 inhibits VEGF-mediated angiogenesis signaling in human endothelial cells. Synonyms: BRN103; BRN103; BRN 103; 2-((1-benzylpiperidin-4-yl)amino)-N-(3-chlorophenyl)nicotinamide. Grade: 98%. CAS No. 1346265-80-2. Molecular formula: C24H25ClN4O. Mole weight: 420.93. | |
| Brodalumab | Brodalumab is a human monoclonal antibody that binds to the interleukin-17 receptor and inhibits the binding of IL-17 to its receptor. Brodalumab has been approved for the treatment of moderate to severe plaque psoriasis. Synonyms: Siliq; Kyntheum; AMG-827; KHK-4827; anti-IL17RA. CAS No. 1174395-19-7. | |
| Brodimoprim | Brodimoprim is a trimethoprim analogue and an oral active dihydrofolate reductase inhibitor. Brodimoprim has high activity against a broad spectrum of gram-negative and gram-positive bacteria. Uses: Enzyme inhibitors. Synonyms: Ro 10-5970; 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine; 5-(4-Bromo-3,5-dimethoxybenzyl)-2,4-pyrimidinediamine; Hyprim; Unitrim. Grade: ≥95%. CAS No. 56518-41-3. Molecular formula: C13H15BrN4O2. Mole weight: 339.19. | |
Our database is helping our users find suppliers everyday.
