BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BYK 191023 dihydrochloride | BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, respectively) acting in a NADPH- and time-dependent manner. BYK 191023 decreases the nitrite levels in rats, and reverses pathological hypotension in the rodent endotoxin model. Synonyms: BYK191023 Dihydrochloride; BYK-191023 Dihydrochloride; BYK 191023 Dihydrochloride; BYK191023 2HCl; BYK-191023 2HCl; BYK 191023 2HCl; ; 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 1216722-25-6. Molecular formula: C14H14N4O.2HCl. Mole weight: 327.21. |  |
| BYK 204165 | BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 = 5.38 and 7.35 for PARP-2 and PARP-1, respectively). BYK 204165 is 100-fold more potent for PARP-1 than PARP-2. Synonyms: PARP Inhibitor XIV; BYK204165; BYK-204165; BYK 204165; RT-017290; RT017290; RT 017290. 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione. Grade: ≥99% by HPLC. CAS No. 1104546-89-5. Molecular formula: C15H12N2O2. Mole weight: 252.27. | |
| BYK 49187 | BYK 49187 is a non-selective PARP inhibitor (pIC50 = 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2, respectively). Synonyms: BYK 49187; BYK49187; BYK-49187; 4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one. Grade: ≥98% by HPLC. CAS No. 163120-31-8. Molecular formula: C19H21N5O. Mole weight: 335.4. | |
| Bz 423 | Bz 423 has been found to be an ATP synthase inhibitor and could suppress disease in lupus-prone mice at some extent. Uses: Immunologic factors. Synonyms: Bz-423; Bz 423; Bz423; 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one. Grade: ≥98% by HPLC. CAS No. 216691-95-1. Molecular formula: C27H21ClN2O2. Mole weight: 440.92. | |
| BzATP triethylammonium salt | The P2X purinergic receptors are ligand-gated ion channels that are activated by extracellular ATP. BzATP triethylammonium salt is a prototypic P2X7 receptor agonist that exhibits 5-10 fold greater potency than ATP with EC50 of 0.7 μM. It also exhibits partial agonist activity at P2X1 and P2Y1 receptors. BzATP can also be used as a photoaffinity probe to study adenine nucleotide binding to ATPases. Synonyms: BzATP; Benzoylbenzoic adenosine 5'-triphosphate. Grade: ≥95%. CAS No. 112898-15-4. Molecular formula: C30H39N6O15P3. Mole weight: 816.6. | |
| BzBzATP (BzATP) | BzBzATP (BzATP) is a P2X7 receptor agonist exhibits high potency at P2X1 receptor (pEC50 = 8.7). Synonyms: 2'/3'-O-(4-benzoylbenzoyl)adenosine-5'-triphosphate, tri(triethylammonium) salt. Grade: ≥ 95% by HPLC. Molecular formula: C24H24N5O15P3*3(C6H15N) [tri(triethylammonium salt)]; C24H24N5O15P3 (free acid). Mole weight: 1018.97 [tri(triethylammonium salt)]; 715.40 (free acid). | |
| C 021 dihydrochloride | C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively). Synonyms: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride. Grade: ≥99%. CAS No. 1784252-84-1. Molecular formula: C27H41N5O2·2HCl. Mole weight: 540.57. | |
| C086 | C086 inhibits Hsp90 and BCR-ABL, resulting in decreased proliferation of tumor cells, including imatinib-resistant cells. Synonyms: C086; C 086; C-086. Grade: >98%. CAS No. 1160107-44-7. Molecular formula: C29H28O8. Mole weight: 504.53. | |
| C-1 | C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 μM, respectively) and is widely used as a ROCK inhibitor. Synonyms: HA 100; HA100; HA-100; 5-Piperazin-1-ylsulfonylisoquinoline; 1-(5-Isoquinolinesulfonyl)piperazine. Grade: ≥99% by HPLC. CAS No. 84468-24-6. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
| C11 TopFluor® GM3 Ammonium salt | C11 TopFluor® GM3 Ammonium salt - a highly pure, fluorescent lipid probe that delves into the intricacies of ganglioside metabolism within biological samples. This remarkable probe is not just limited to that though; it can alight on GM3 gangliosides within cells that are involved in disruptive lipid-related diseases like neurodegeneration, inherited metabolic disorders and cancer. That's not all - TopFluor® GM3's exceptional structural and fluorescence properties place it on a pedestal as an invaluable tool for scrutinizing lipid membrane dynamics and signal transduction pathways with great precision. Synonyms: C11 TopFluor GM3 Ganglioside (ammonium salt); Borate(1-), [N-[(1S,2R,3E)-1-[[[O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-λ-(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)-3,5-dimethyl-1H-pyrrole-2-dodecanamidato(2-)-κN1]difluoro-, ammonium (1:1), (T-4)-; (T-4)-[N-[(1S,2R,3E)-1-[[[O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-λ-(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)-3,5-dimethyl-1H-pyrrole-2-dodecanamidato(2-)-κN1]difluoroborate(1-) ammonium salt. CAS No. 2260795-48-8. Molecular formula: C65H110BF2N5O21. Mole weight: 1346.40. | |
| C-1311 dihydrochloride | C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued. Uses: Anticancer agents. Synonyms: Imidacrine; XLS-002; C-1311 dihydrochloride; XLS 002; C 1311 dihydrochloride; XLS002; C1311 dihydrochloride; Symadex; Imidazoacridinone; CHEMBL3545337; 5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one. Grade: 98%. CAS No. 138154-55-9. Molecular formula: C20H26Cl2N4O3. Mole weight: 441.35. | |
| C16 | C16 is an inhibitor of RNA-activated protein kinase (PKR) (IC50 = 210 nM). It is an imidazolo-oxindole derivative that binds to ATP-binding site of PKR and rescues PKR-dependent translation block in vitro. C16 has neuroprotective activity against cell damage in human neuroblastoma cells and neuroinflammation in acute excitotoxic rat model. Synonyms: GW-506033X; GW 506033X; GW506033X; C16, PKR Inhibitor; 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one. Grade: ≥98% by HPLC. CAS No. 608512-97-6. Molecular formula: C13H8N4OS. Mole weight: 268.29. | |
| C16 Ceramide-1-phosphate (d18:1/16:0) ammonium salt | C16 Ceramide-1-phosphate (C16 C1P) is one of the main forms of C1P found in cells. It is created by phosphorylation of by ceramide kinase. It activates cytosolic phospholipase A2α (PLA2α) and stimulates the release of arachidonic acid in A549 cells. Synonyms: C16 C1P; C16 Ceramide-1-phosphate; N-(hexadecanoyl)-sphing-4-enine-1-phosphate; CerP(d18:1/16:0). Grade: ≥98%. CAS No. 1246303-22-9. Molecular formula: C34H71N2O6P. Mole weight: 634.91. | |
| C16 Galactosyl(α) Ceramide (d18:1/16:0) | It is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid. Synonyms: D-galactosyl-α-1,1'-N-palmitoyl-D-erythro-sphingosine; Hexadecanamide, N-[(1S,2R,3E)-1-[(α-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-; α C16 Galactosylceramide (d18:1/16:0); C16 α-D-galactosyl ceramide; N-(hexadecanoyl)-1-α-galactosyl-sphing-4-enine; N-((2S,3R,E)-3-hydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadec-4-en-2-yl)palmitamide; N-[(2S,3R,4E)-1-(α-D-Galactopyranosyloxy)-3-hydroxy-4-octadecen-2-yl]hexadecanamide; α-GalCer(d18:1/16:0). Grade: >99%. CAS No. 2260795-77-3. Molecular formula: C40H77NO8. Mole weight: 700.04. | |
| C17:0 GA2 | C17:0 GA2, the renowned biomarker utilized in the biomedical realm, serves as an undeniably valuable asset for diagnosing the genetic ailment, namely Gaucher disease, which is fundamentally instigated by the inadequacy of glucocerebrosidase. Remarkably, the levels of C17:0 GA2 are considerably heightened in both blood and urine of afflicted individuals, rendering it an efficacious tool for the prompt detection and progressive monitoring of the disease. Synonyms: C17:0 Galabiosylceramide; N-[(1S,2R,3E)-1-[[(4-O-α-D-Galactopyranosyl-β-D-galactopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]heptadecanamide. Grade: >99%. CAS No. 2315262-51-0. Molecular formula: C47H89NO13. Mole weight: 876.21. | |
| C17:0 iGB3 | C17:0 iGb3, a synthetic analogue of iGb3 that plays a pivotal role in immunostimulation. With its unique glycolipid composition, this powerful compound has exhibited promising potential in the treatment of cancer by priming the immune system against malignant cells. Moreover, recent research suggests that C17:0 iGb3 may also hold therapeutic promise in the management of infectious diseases and autoimmune disorders. Discover the cutting-edge scientific complexities behind C17:0 iGb3 and its potential impact on human health. Synonyms: C17:0 Isoglobotriaosylceramide; N-[(1S,2R,3E)-1-[[(O-α-D-Galactopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]heptadecanamide. Grade: >99%. CAS No. 2315262-50-9. Molecular formula: C53H99NO18. Mole weight: 1038.35. | |
| C-176 | C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grade: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09. | |
| C-178 | C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grade: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27. | |
| C18 L-erythro Ceramide (d18:1/18:0) | C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. It can inhibit rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM. Synonyms: L-erythro Cer(d18:1/18:0); L-erythro Ceramide (d18:1/18:0); N-octadecanoyl-L-erythro-sphingosine. Grade: ≥98%. CAS No. 252039-52-4. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| C18 L-threo Ceramide (d18:1/18:0) | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grade: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| C-(1-Bromo-1-deoxy-2,3,4,6-tetra-O-benzoyl-b-D-glucopyranosyl)formamide | C-(1-Bromo-1-deoxy-2,3,4,6-tetra-O-benzoyl-b-D-glucopyranosyl)formamide is a vital component in the development of novel antiviral drugs. Through its unique chemical structure, it exhibits potent antiviral activity against a range of infectious diseases, including influenza and herpes viruses. Synonyms: C-(2,3,4,6-Tetra-O-benzoyl-1-bromo-1-deoxy-b-D-glucopyranosyl)formamide. CAS No. 262849-68-3. Molecular formula: C35H28BrNO10. Mole weight: 702.50. | |
| C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-a-D-galactopyranosyl)formamide | C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-a-D-galactopyranosyl)formamide is a valuable compound utilized in the biomedical industry for its potential in treating infectious diseases caused by specific bacteria or viruses. Its structure and chemical properties make it an effective candidate for the development of antiviral or antibacterial drugs. Synonyms: C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-alpha-D-galactopyranosyl)formamide. CAS No. 180904-09-0. Molecular formula: C15H20N4O10. Mole weight: 416.34. | |
| C-(2,3,4,6-Tetra-O-acetyl-1-bromo-1-deoxy-b-D-galactopyranosyl)formamide | C-(2,3,4,6-Tetra-O-acetyl-1-bromo-1-deoxy-b-D-galactopyranosyl)formamide, an extensively researched and promising biomedical compound, exhibits immense potential for therapeutic applications. With its commendable prowess as a glycosylation reagent in synthesizing glycosides, oligosaccharides, and bioactive molecules, this exceptional product assumes a pivotal role in drug development. Synonyms: α-D-galacto-2-Heptulopyranosonamide, 2-bromo-2-deoxy-, 3,4,5,7-tetraacetate. CAS No. 159895-07-5. Molecular formula: C15H20BrNO10. Mole weight: 454.22. | |
| C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide | C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a compound used in the research of various diseases playing a crucial role in targeting specific cellular pathways associated with compound resistance and cancer progression. Synonyms: C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-beta-D-galactopyranosyl)formamide. CAS No. 189633-60-1. Molecular formula: C15H21NO11. Mole weight: 391.33. | |
| C-(2,3,4-Tri-O-acetyl-1-azido-1-deoxy-b-D-galactopyranosyl)formamide | C-(2,3,4-Tri-O-acetyl-1-azido-1-deoxy-b-D-galactopyranosyl)formamide, a renowned compound extensively applied within the biomedical industry, emerges as an indubitably vital asset enhancing drug development and research endeavors. It manifests considerable potential in ameliorating an array of ailments, predominantly those entrenched in the realms of cellular and molecular biology. Synonyms: α-D-arabino-2-Hexulopyranosonamide, 2-azido-2-deoxy-, 3,4,5-triacetate (9CI). CAS No. 189633-67-8. Molecular formula: C12H16N4O8. Mole weight: 344.28. | |
| C-(2,3,4-Tri-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide | C-(2,3,4-Tri-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a biomedical product used for the study of certain diseases. It acts as a formamide derivative of galactose, which exhibits potential antitumor activity against various cancer types. Synonyms: β-D-arabino-2-Hexulopyranosonamide, 3,4,5-triacetate (9CI). CAS No. 189633-66-7. Molecular formula: C12H17NO9. Mole weight: 319.26. | |
| C24:1 b-D-Galactosyl ceramide | C24:1 b-D-Galactosyl ceramide is a renowned compound prevalent in the ever-evolving biomedical realm, specifically tailored for the research of diverse afflictions, including Gaucher disease and Fabry disease. Synonyms: Galactosyl-b-1,1 N-nervonoyl-D-erythro-sphingosine. Grade: >99%. CAS No. 17283-91-9. Molecular formula: C48H91NO8. Mole weight: 810.24. | |
| C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt | C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt is a valuable compound serving as a formidable biomarker facilitating the comprehensive investigation of ceramide involvement in diverse pathological conditions, spanning from malignancies such as cancer, to metabolic disorders like diabetes is and even neurodegenerative ailments. Synonyms: 3-O-Sulfo-D-galactosyl-alpha-1,1'-N-Nervonoyl-D-erythro-sphingsoine (ammonium salt); 3-O-sulfo-alpha-D-C24:1-galactosylceramide (ammonium salt); ammonium (2S,3R,4S,5S,6R)-3,5-dihydroxy-2-(((2S,3R,E)-3-hydroxy-2-((Z)-tetracos-15-enamido)octadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl sulfate; Ammonium (2S,3R,4E)-3-hydroxy-2-[(15Z)-15-tetracosenoylamino]-4-octadecen-1-yl 3-O-sulfonato-α-D-threo-hexopyranoside; 15-Tetracosenamide, N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-α-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-, ammonium salt (1:1), (15Z)-. Grade: >99%. CAS No. 2260670-38-8. Molecular formula: C48H94N2O11S. Mole weight: 907.33. | |
| C25-140 | C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 was found to impede NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. CAS No. 1358099-18-9. Molecular formula: C26H31N7O. Mole weight: 457.57. | |
| C29 | C29 is a potential TLR2 inhibitor. C29 inhibited TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Synonyms: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.30. | |
| C2 Adamantanyl Galactosylceramide (d18:1/2:0) | C2 Adamantanyl Galactosylceramide (d18:1/2:0) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. Synonyms: [(2S,3R,4E)-2-[(1-Adamantyl)acetylamino]-3-hydroxy-4-octadecenyl]beta-D-galactopyranoside; N-(1-Adamantaneacetyl)-galactosylceramide; Adamantanyl Galactosyl(β) Ceramide; AdaGalCer(d18:1/2:0). Grade: ≥98%. CAS No. 574738-16-2. Molecular formula: C36H63NO8. Mole weight: 637.89. | |
| C2 Adamantanyl Glucosylceramide (d18:1/2:0) | C2 Adamantanyl glucosylceramide (AdaGluCer) is a bioactive sphingolipid. It increases levels of glycosphingolipids in Vero cells at low concentrations (≤20 μM) but decreases them at high concentrations (≥40 μM). Pretreatment of microsomes with AdaGluCer increases production of adamantanyl lactosylceramide (AdaLacCer) and reduces synthesis of LacCer from exogenous GlcCer. AdaGluCer inhibits glucocerebrosidase activity in vitro in a pH-dependent manner. Synonyms: N-(1-Adamantaneacetyl) Glucosylceramide; Adamantanyl GluCer(d18:1/2:0); Adamantanyl Glucosylceramide (d18:1/2:0); AdaGluCer(d18:1/2:0). Grade: ≥98%. Molecular formula: C36H61NO8. Mole weight: 635.87. | |
| C2,C8-Dimethyladenosine | C2,C8-Dimethyladenosine, a nucleoside derivative prevalently employed in the biomedical sector, assumes a critical function in the amalgamation of innovative pharmaceuticals for the purpose of combating diverse ailments. Its profound attributes render it a coveted asset for both researchers and pharmaceutical firms engaged in the exploration and advancement of medicinal remedies. Molecular formula: C12H17N5O4. Mole weight: 295.30. | |
| C2-Ceramide | C2-Ceramide is a potent modulator of cell proliferation and differentiation and it has been found to activate protein phosphatase-1 (PP1) and PP2A, as well as ceramide-activated protein phosphatase (CAPP) in vitro. Synonyms: N-acetoyl-D-erythro-sphingosine; N-(acetoyl)-sphing-4-enine; Cer(d18:1/2:0); N-(acetyl)-ceramide; Acetamide, N-(2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl)-, (R-(R*,S*-(E)))-; D-erythro-N-acetyl-sphingosine; C2 Ceramide (d18:1/2:0); N-Acetylsphingosine; N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]acetamide; Acetyl Ceramide. Grade: ≥98% by HPLC. CAS No. 3102-57-6. Molecular formula: C20H39NO3. Mole weight: 341.53. | |
| C2 Ceramide (d14:1/2:0) | C2 Ceramide (d14:1/2:0) is a component used to diagnose diseases associated with COX2 overexpression. It shows strong binding activity to COX2 protein. (Extracted from patent WO2019235824A1). Synonyms: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-tridecen-1-yl]-acetamide; N-[(2S,3R,4E)-1,3-Dihydroxy-4-tetradecen-2-yl]acetamide; Cer(d14:1/2:0); N-acetyl-D-erythro-Sphingosine C14. Grade: ≥95%. CAS No. 2097561-20-9. Molecular formula: C16H31NO3. Mole weight: 285.42. | |
| C34 | C34 is a TLR4 inhibitor. Synonyms: C 34; C-34; TLR4-IN-C34; 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate; Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside; α-D-Glucopyranoside, 1-methylethyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate; Isopropyl 3,4,6-tri-O-acetyl-α-D-GlcNAc; Toll-Like Receptor 4-C34; TLR-C 34; TLR-C34; Isopropyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate; Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-glucopyranoside. Grade: ≥98%. CAS No. 40592-88-9. Molecular formula: C17H27NO9. Mole weight: 389.40. | |
| C3a 70-77 acetate | C3A (70-77), an octapeptide corresponding to the COOH terminal of C3A, shows C3a specificity and 1-2% bioactivity. Molecular formula: C37H65N13O12. Mole weight: 883.99. | |
| c[3'-AHC-G(2',5')pA(3',5')p] | c[3'-AHC-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which can be used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. Synonyms: Cyclic (3'- O- (6- aminohexylcarbamoyl)guanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C27H38N12O14P2 (free acid). Mole weight: 816.6 (free acid). | |
| C3a Receptor Agonist | Complement 3a (C3a) Receptor Agonist is a G protein-coupled receptor protein involved in the complement system complement pathway. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. It stimulates differentiation of neural progenitor cells in vitro. Synonyms: C3A Receptor Agonist; 944997-60-8; C3a receptor agonist 1; 2-cyclohexyl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamide; CHEMBL390036; CHEMBL535625; 2-cyclohexyl-2-phenyl-N-(1-(3-(pyridin-3-yl)propanoyl)piperidin-4-yl)acetamide; 2-Cyclohexyl-2-phenyl-N-{1-[3-(pyridin-3-yl)propanoyl]piperidin-4-yl}acetamide; Complement 3a Receptor Agonist; SCHEMBL14335900; GTPL11252; DTXSID90659061; BDBM50423085; AKOS028114559; compound 7 [PMID: 17459702]; MS-27755; HY-128132; CS-0095343; C3A Receptor Agonist, >=98% (HPLC), solid; F87576. Grade: ≥98%. CAS No. 944997-60-8. Molecular formula: C27H35N3O2. Mole weight: 433.6. | |
| C3bot (154-182) | C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. It promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations and promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. It reduces levels of active neuronal RhoA by a non-enzymatic mechanism and enhances functional recovery and regeneration in a mouse model of spinal cord injury. Synonyms: C3bot (154-182); 1246280-79-4. CAS No. 1246280-79-4. Molecular formula: C137H221N37O40S. Mole weight: 3058.54. | |
| c[3'-Fluo-AHC-G(2',5')pA(3',5')p] | c[3'-Fluo-AHC-G(2',5')pA(3',5')p] is a fluorescent analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator. Synonyms: Cyclic(3'-O-(6-[fluoresceinyl]aminohexylcarbamoyl)guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C48H48N12O20P2. Mole weight: 1174.9. | |
| C3-Spacer-CEP | C3-Spacer-CEP is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required. Synonyms: 3-(4,4'-Dimethoxytrityloxy)propyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Spacer Phosphoramidite C3; 3-(Bis(4-methoxyphenyl)phenylmethoxy)propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-(bis(4-methoxyphenyl)phenylmethoxy)propyl 2-cyanoethyl ester; Spacer-C3 CEP; Spacer-C3 Phosphoramidite; 3-(Bis(4-methoxyphenyl)(phenyl)methoxy)propyl (2-cyanoethyl) diisopropyl phosphoramidite. Grade: ≥98.0%. CAS No. 110894-23-0. Molecular formula: C33H43N2O5P. Mole weight: 578.68. | |
| C527 | C527 is an inhibitor of USP1/UAF complex deubiquitinase activity. It is a high potency for the USP1/UAF1 complex with IC50 of 0.88 μM. C527 increases ubiquinated Fanconi anemia complementation group D2 (FANCD2-Ub) and FANCI-Ub levels in a concentration-dependent manner. It also inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C. Synonyms: C-527; C 527. Grade: ≥98%. CAS No. 192718-06-2. Molecular formula: C17H8FNO3. Mole weight: 293.3. | |
| C646 | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases. Synonyms: C646; C-646; C 646. Grade: >98%. CAS No. 328968-36-1. Molecular formula: C24H19N3O6. Mole weight: 445.42. | |
| C6(6-azido) GalCer | It is a modified lipid containing an omega-terminal azide. In the presence of a coppery(Cu)-containing catalyst, the terminal azide group can be used for highly specific binding reactions with alkyne-containing reagents, known as ''click chemistry''. Synonyms: D-Galactosyl-β-1,1'-N-(6''-azidohexanoyl)-D-erythro-sphingosine; C6(6-azido) Galactosyl(β) Ceramide; 6-Azido-N-[(1S,2R,3E)-1-[(β-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]hexanamide. Grade: >99%. CAS No. 2260670-20-8. Molecular formula: C30H56N4O8. Mole weight: 600.79. | |
| C6(6-azido) GluCer | It is a modified lipid containing an omega-terminal azide. In the presence of a coppery(Cu)-containing catalyst, the terminal azide group can be used for highly specific binding reactions with alkyne-containing reagents, known as ''click chemistry''. Synonyms: D-Gluctosyl-β-1,1'-N-(6''-azidohexanoyl)-D-erythro-sphingosine; C6(6-azido) Gluctosyl(β) Ceramide; 6-Azido-N-[(1S,2R,3E)-1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]hexanamide. Grade: >99%. CAS No. 2260670-21-9. Molecular formula: C30H56N4O8. Mole weight: 600.79. | |
| C6(6-azido) LacCer | It is a modified lipid containing an omega-terminal azide. In the presence of a coppery(Cu)-containing catalyst, the terminal azide group can be used for highly specific binding reactions with alkyne-containing reagents, known as ''click chemistry''. Synonyms: D-Lactosyl-β-1,1'-N-(6''-azidohexanoyl)-D-erythro-sphingosine; C6(6-azido) Lactosyl(β) Ceramide; 6-Azido-N-[(1S,2R,3E)-1-[[(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]hexanamide. Grade: >99%. CAS No. 2260670-19-5. Molecular formula: C36H66N4O13. Mole weight: 762.93. | |
| C7280948 | C7280948 is a novel PRMT1 inhibitor ( IC50=12.75 μM). Uses: A novel prmt1 inhibitor. Synonyms: C7280948; C-7280948; C 7280948; 4-amino-N-(2-phenylethyl)benzenesulfonamide; 4-amino-N-phenethylbenzenesulfonamide. Grade: ≥95%. CAS No. 587850-67-7. Molecular formula: C14H16N2O2S. Mole weight: 276.35. | |
| C75 | C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer. Synonyms: C 75 trC-75 trans-racemic; trans-C75; C 75; C75; C-75. Grade: >98%. CAS No. 218137-86-1. Molecular formula: C14H22O4. Mole weight: 254.32. | |
| C75 trans | trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a cell cycle arrest inducer in hepatocellular carcinoma (HCC) cell lines. It has also been shown to blocks resistin-induced increases in lipid accumulation by human macrophages. Synonyms: C 75 trC-75 trans-racemic; trans-C75. Grade: >98%. CAS No. 191282-48-1. Molecular formula: C14H22O4. Mole weight: 254.32. | |
| C 87 | C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). It was shown to inhibit TNF-α-induced cytotoxicity in L929 fibroblast cells, attenuate inflammation and increase survival in a mouse hepatitis model. Synonyms: TNFalpha-IN-C87; 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]. Grade: ≥98% by HPLC. CAS No. 332420-90-3. Molecular formula: C24H15ClN6O3S. Mole weight: 502.93. | |
| c[8-AET-G(2',5')pA(3',5')p] | c[8-AET-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which is used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. c[G(2',5')pA(3',5')p] is the metazoan second messenger produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. Synonyms: Cyclic (8- (2- aminoethylthio)guanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C22H29N11O13P2S (free acid). Mole weight: 749.6 (free acid). | |
| c[8-AET-G(2',5')pA(3',5')p]-Agarose | c[8-AET-G(2',5')pA(3',5')p]-Agarose is the metazoan cyclic dinucleotide second messenger c[G(2',5)pA(3',5')p] immobilized on agarose by an aminoethylthio spacer, which possibly can be used in affinity chromatography of c[G(2',5')pA(3',5')p]-responsive proteins. Synonyms: Cyclic (8- (2- aminoethylthio)guanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), immobilized on agarose gel. | |
| C8-Alkyne-dCTP | C8-Alkyne-dCTP is a modified nucleoside triphosphate utilized in the field of DNA research. Its unique chemical structure enables it to be incorporated into DNA sequences during polymerase chain reaction (PCR), allowing for the detection and analysis of DNA-protein interactions. C8-Alkyne-dCTP is commonly used in studies focused on drug discovery and disease diagnosis within the biomedical industry. Synonyms: 5-(Octa-1,7-diynyl)-2'-deoxycytidine 5'-triphosphate, Sodium salt. Grade: ≥ 99%. Molecular formula: C17H24N3O13P3 (free acid). Mole weight: 571.31 (free acid). | |
| C8-Alkyne-dUTP | C8-Alkyne-dUTP can be incorporated into DNA by PCR with family B polymerases to produce modified DNA. Synonyms: 5-(Octa-1,7-diynyl)-2'-deoxyuridine 5'-triphosphate, Sodium salt. Grade: ≥ 99%. Molecular formula: C17H23N2O14P3 (free acid). Mole weight: 572.29 (free acid). | |
| c[8-Br-G(2',5')pA(3',5')p] | c[8-Br-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger, which can be used for binding studies and as precursor for further modifications with spacers or labels. c[G(2',5')pA(3',5')p] is the metazoan second messenger produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. Synonyms: Cyclic (8- bromoguanosine- (2' -≥ 5')- monophosphate- adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H23BrN10O13P2 (free acid). Mole weight: 753.3 (free acid). | |
| c[8-Fluo-AET-G(2',5')pA(3',5')p] | c[8-Fluo-AET-G(2',5')pA(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is a potential tracer in immunoassays and commonly used for affinity chromatography and pull-down assays. Synonyms: Cyclic(8-(2-[fluoresceinyl]aminoethylthio)-guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C43H39N11O19P2S (free acid). Mole weight: 1107.9 (free acid). | |
| CA-074 methyl ester | CA-074 Me is a membrane-permeable inhibitor of irreversible cathepsin B derived from CA-074. CA-074 Me would be hydrolyzed by intracellular esterases to CA-074, the active compound. Synonyms: Ca-074Me; Ca 074Me; Ca074Me; Cathepsin B Inhibitor IV; MFCD03452890; (S)-methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylate; CA-074 Me. Grade: 99.04 %. CAS No. 147859-80-1. Molecular formula: C19H31N3O6. Mole weight: 397.47. | |
| c[A(2',5')pA(2',5')p] | c[A(2',5')pA(2',5')p] is a cyclic dinucleotide analogue of c-diAMP, the bacterial second messenger. Synonyms: Cyclic (adenosine- (2' -≥ 5')- monophosphate- adenosine- (2' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H24N10O12P2. Mole weight: 658.4. | |
| c[A(2',5')pS[Sp]-A(3',5')pS[Rp]] | c[A(2',5')pS[Sp]-A(3',5')pS[Rp]] is asyntheticdi-thiophosphate analogue of c[A(2',5')pA(3',5')p] with higher stability resisting degradation by phosphodiesterases. Grade: ≥ 95% by HPLC. CAS No. 1638242-31-5. Molecular formula: C20H24N10O10P2S2 (free acid). Mole weight: 690.6 (free acid). | |
| Ca2+ Channel Agonist 1 | A Ca2+ Channel Agonist that selectively acting on N-type Ca2+ channel and also be found to restrain the cdk activity at some extent. IC50: 14.23 uM (EC50, Ca2+ channel) 3.34 uM (EC50, cdk2). Uses: A ca2+ channel agonist that selectively acting on n-type ca2+ channel and also be found to restrain the cdk activity at some extent. Synonyms: Ca2+ channel agonist 1; SCHEMBL17628623; CS-5169; CS 5169; CS5169. Grade: 98%. CAS No. 1402821-24-2. Molecular formula: C19H26N6O. Mole weight: 354.46. | |
| CA-4948 | CA-4948 is a potent and selective IRAK4 inhibitor that can be used for the treatment of cancers with dysregulated TLR/MYD88/IRAK4 signaling. Synonyms: CA-4948; CA 4948; CA4948; 6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide. Grade: >98%. CAS No. 1801343-74-7. Molecular formula: C21H19N7O3. Mole weight: 417.429. | |
| CA-5f | CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. It exhibited strong cytotoxicity against A549 non-small cell lung cancer (NSCLC) cells. CA-5f effectively suppressed the growth of A549 lung cancer xenograft as a single agent with an excellent tolerance in vivo. Synonyms: CA5f. Grade: ≥98%. CAS No. 1370032-19-1. Molecular formula: C24H24N2O3. Mole weight: 388.46. | |
| CA77.1 | CA77.1 is a brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD). Synonyms: CA. CAS No. 2412270-22-3. Molecular formula: C16H12ClN3O. Mole weight: 297.74. | |
| Cabazitaxel | Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Synonyms: XRP6258; XRP-6258; XRP 6258; TXD 258; TXD-258; TXD258; RPR116258A; axoid XRP6258; dimethoxydocetaxel US brand name: Jevtana. Grade: >98%. CAS No. 183133-96-2. Molecular formula: C45H57NO14. Mole weight: 835.93. | |
| Cabazitaxel Impurity | 10-Deacetyl-7,10-dimethoxy-Baccatin III is an intermediate used to prepare Cabazitaxel. Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; [2aR-(2aα,4β,4aβ,6β,9α,11α,12α,12aα. Grade: > 95%. CAS No. 183133-94-0. Molecular formula: C31H40O10. Mole weight: 572.66. | |
| Cabazitaxel Impurity 12 | an impurity of cabazitaxel. Synonyms: 2-Azetidinone, 3-hydroxy-4-phenyl-, (3S,?4R)?-. Grade: > 95%. CAS No. 146924-92-7. Molecular formula: C9H9NO2. Mole weight: 163.18. | |
| Cabazitaxel Impurity 15 | an impurity of an antineoplastic agent cabazitaxel. Synonyms: 3,?5-Oxazolidinedicarboxy?lic acid, 2-(4-methoxyphenyl)?-4-phenyl-, 3-(1,?1-dimethylethyl) ester, (4R,?5S)?-. Grade: > 95%. CAS No. 859498-34-3. Molecular formula: C22H25NO6. Mole weight: 399.45. | |
| Cabazitaxel Impurity (DiTroc) | A intermediate in the synthesis of a metabolite of Docetaxel, an antineoplastic. Synonyms: Carbonic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-4,6-diyl bis(2,2,2-trichloroethyl) E. Grade: > 95%. CAS No. 95603-44-4. Molecular formula: C35H38Cl6O14. Mole weight: 895.4. | |
| Cabazitaxel Impurity (Oxazolidine Protected) | Oxazolidine Cabazitaxel is an impurity of Cabazitaxel which is a novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. Synonyms: (4S,5R)-2,2-Dimethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 5-[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cycl. Grade: > 95%. CAS No. 1373171-12-0. Molecular formula: C48H61NO14. Mole weight: 876.02. | |
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