BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Burnettramic acid A | Burnettramic acid A is a fungal metabolite found in A. burnettii which has diverse biological activities. It is active against B. subtilis, S. aureus, C. albicans, and S. cerevisiae (IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is also cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). Synonyms: (2Z,6R,7aS)-tetrahydro-6-hydroxy-2-[(2S,4R,12E,15R,19R)-1,15,19-trihydroxy-26-(β-D-mannopyranosyloxy)-2,4-dimethyl-14-hexacosen-1-ylidene]-1H-pyrrolizine-1,3(2H)-dione. Grade: >95% by HPLC. CAS No. 2334483-46-2. Molecular formula: C41H71NO12. Mole weight: 770.00. |  |
| Burnettramic acid A aglycone | Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A that has been found in A. burnettii and it has anticancer activity. It is also cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). Synonyms: Burnettramic acid A aglycone(; 2Z,6R,7aS)-tetrahydro-6-hydroxy-2-[(2S,4R,12E,15R,19R)-1,15,19,26-tetrahydroxy-2,4-dimethyl-12-hexacosen-1-ylidene]-1H-pyrrolizine-1,3(2H)-dione; 2396676-46-1; (2Z,6R,8S)-6-hydroxy-2-[(E,2S,4R,15R,19R)-1,15,19,26-tetrahydroxy-2,4-dimethylhexacos-12-enylidene]-5,6,7,8-tetrahydropyrrolizine-1,3-dione; HY-N10257. Grade: >95% by HPLC. CAS No. 2396676-46-1. Molecular formula: C35H61NO7. Mole weight: 607.86. | |
| Burosumab | Burosumab is a human monoclonal antibody targeting the phosphaturic hormone fibroblast growth factor 23 (FGF23). Burosumab is currently in a phase III clinical trial for the treatment of patients with X-linked hypophosphatemia. Uses: The potential treatment of x-linked hypophosphatemia. Synonyms: KRN-23; KRN 23; KRN23. CAS No. 1610833-03-8. | |
| Busperidone Impurity K | Buspirone intermediate. Synonyms: 8-azaspiro[4.5]decane-7,9-dione; 1,1-Cyclopentanediacetimide; 3-Spirocyclopentaneglutarimide. Grade: > 95%. CAS No. 1075-89-4. Molecular formula: C9H13NO2. Mole weight: 167.21. | |
| Buspirone EP Impurity J | Buspirone EP Impurity J is a a derivative of buspirone, a steadfast serotonin receptor agonist imbued with anxiolytic attributes. Synonyms: 4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl 2-(1-(2-oxo-2-((4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)amino)ethyl)cyclopentyl)acetate. Grade: > 95%. Molecular formula: C34H52N6O5. Mole weight: 624.83. | |
| Buspirone Hydrochloride | Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders. Uses: Anti-anxiety agents. Synonyms: 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione; Ansial; Ansiced; Axoren; Bespar; Buspar; Narol. Grade: >98%. CAS No. 33386-08-2. Molecular formula: C21H31N5O2.HCl. Mole weight: 421.96. | |
| Buspirone N-Oxide | Buspirone N-Oxide is a metabolite of Buspirone, a 5-hydroxytryptamine (5-HT1) receptor agonist. Synonyms: 8-[4-[1-Oxido-4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione. Grade: > 95%. CAS No. 220747-81-9. Molecular formula: C21H31N5O3. Mole weight: 401.51. | |
| Busulfan | Busulfan is a cell cycle non-specific alkylating antineoplastic agent. Uses: Antineoplastic agents, alkylating. Synonyms: 1,4-Butanediol-dimethanesulfonate Esters; Busulphan; CB-2041; GT-41; Busulfex; Misulban; Myleran. Grade: >98%. CAS No. 55-98-1. Molecular formula: C6H14O6S2. Mole weight: 246.3. | |
| Busulfan Impurity 1 | 4-Methanesulfonyloxybutanyl Methanesulfinate is a substituted Sulforaphane analogue and a potential inducer of phase II detoxifying enzyme. Synonyms: Methanesulfinic acid, 4-[(methylsulfonyl)?oxy]?butyl ester. Grade: > 95%. CAS No. 1797106-48-9. Molecular formula: C6H14O5S2. Mole weight: 230.3. | |
| Busulfan Impurity 3 | an impurity of busulfan. Synonyms: 4-Hydroxybutane-1-sulfonic acid; Nsc 163335; Nsc 71873; Benzenediazonium,2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]-. Grade: > 95%. CAS No. 26978-64-3. Molecular formula: C4H10O4S. Mole weight: 154.19. | |
| Busulfan Impurity 4 | 4-Methanesulfonyloxybutanol is a hydrolysis product of busulfan which is an Alkylating agent with antileukemic activity. Synonyms: 4-Methanesulfonyloxybutanol; 1,4-Butanediol Monomethanesulfonate; NSC 67176. Grade: > 95%. CAS No. 42729-95-3. Molecular formula: C5H12O4S. Mole weight: 168.21. | |
| Busulfan Impurity 5 | 1-Acetate 4-Methanesulfonate 1,4-Butanediol is used in the facile cleavage of ethers. Synonyms: 1-Acetate 4-Methanesulfonate 1,4-Butanediol; 4-((Methylsulfonyl)oxy)butyl acetate. Grade: > 95%. CAS No. 19859-00-8. Molecular formula: C7H14O5S. Mole weight: 210.25. | |
| Butabindide oxalate | The oxalate salt form of Butabindide, which is a CCK-inactivating serine protease inhibitor. Synonyms: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate. Grade: ≥99% by HPLC. CAS No. 185213-03-0. Molecular formula: C17H25N3O2.C2H2O4. Mole weight: 393.44. | |
| Butamirate | Butamirate (or brospamin) is a cough suppressant. A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity. As a 2-(2-diethylaminoethoxy)ethyl ester it is chemically related to oxeladin and pentoxyverine, which are in the same class. Synonyms: Butamirate; Butamyrate; 2-Phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester; Benzeneacetic acid, alpha-ethyl-, 2-(2-(diethylamino)ethoxy)ethyl ester; Brospamin; Butamirate [inn:ban]; Butamirato; Butamirato [inn-spanish]. Grade: > 95%. CAS No. 18109-80-3. Molecular formula: C18H29NO3. Mole weight: 370.44. | |
| Butamirate Citrate | Butamirate is a cough suppressant. A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity. As a 2-(2-diethylaminoethoxy)ethyl ester it is chemically related to oxeladin and pentoxyverine, which are in the same class. Synonyms: Butamirate citrate; diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammonium dihydrogen citrate; Butamiratdihydrogencitrat; Abbott 36581; HH-197; 2-(2-diethylaminoethyloxy)ethyl 2-phenylbutanoate; 2-phenylbutyric acid 2-(2-diethylaminoethyloxy)ethyl ester; 2-[2-(. Grade: > 95%. CAS No. 18109-81-4. Molecular formula: C18H29NO3 C6H8O7. Mole weight: 370.44 192.13. | |
| Butamirate Impurity 1 | an impurity of Butamirate. Synonyms: Benzeneacetamide, N,?N,?α-triethyl-; Butyramide, N,N-diethyl-2-phenyl- (6CI,7CI). Grade: > 95%. CAS No. 92321-53-4. Molecular formula: C15H22O. Mole weight: 218.34. | |
| Butamirate Impurity 2 | an impurity of Butamirate. Synonyms: Benzeneacetic acid, 2-[2-(diethylamino)?ethoxy]?ethyl ester. Grade: > 95%. CAS No. 47092-75-1. Molecular formula: C16H25NO3. Mole weight: 279.38. | |
| Butamirate Impurity 3 | an impurity of Butamirate. Synonyms: Benzeneacetic acid, α-ethyl-, methyl ester. Grade: > 95%. CAS No. 2294-71-5. Molecular formula: C11H14O2. Mole weight: 178.23. | |
| Butanoic acid, 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]hydroxyamino]-, sodium salt | An impurity of Elagolix sodium, a medication indicated for the treatment of moderate to severe pain associated with endometriosis. Grade: 95%. CAS No. 2486454-63-9. Molecular formula: C32H30F5N3O6Na. Mole weight: 670.58. | |
| Butaprost | Butaprost is a structural analog of PGE2 and a selective agonist for the EP2 receptor subtype. It binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor. Butaprost does not bind appreciably to any of the other murine EP receptors. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1; 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1. Grade: ≥95%. CAS No. 433219-55-7. Molecular formula: C23H38O5. Mole weight: 394.6. | |
| Butenoyl PAF | Platelet-activating factor (PAF) is a lipid mediator that is well-known for its ability to cause platelet aggregation, inflammation, and allergic response at very low concentrations (approaching picomolar). Butenoyl PAF is a PAF receptor agonist, which is the product of the oxidative decomposition of 2-arachidonoyl phospholipids. It is 100-fold more abundant in oxidized LDL than PAF. Synonyms: Butenoyl PAF. Grade: ≥98%. CAS No. 474944-25-7. Molecular formula: C28H56NO7P. Mole weight: 549.7. | |
| Buthionine Sulphoximine | Buthionine Sulphoximine, also known as NSC-326231, is a potent and specific inhibitor of alpha-glutamyl cysteine synthetase. Uses: Antimetabolites, antineoplastic. Synonyms: 2-amino-4-(butylsulfonimidoyl)butanoic acid; NSC-326231; NSC 326231; NSC326231; BSO; Buthionine Sulphoximine; DL-Buthionine-(S,R)-sulfoximine. CAS No. 5072-26-4. Molecular formula: C8H18N2O3S. Mole weight: 222.3. | |
| Butibufen | Butibufen, a non-steroidal anti-inflammatory compound with oral activity, is a potential cyclooxygenase inhibitor with analgesic and antipyretic activities. Butibufen inhibits urea synthesis and can be used to study rheumatic diseases. Uses: Anti-inflammatory. Synonyms: FF-106; 2-(4-Isobutylphenyl)butanoic acid; Butilopan; 2-(p-Isobutylphenyl)butyric acid; 2-(4-Isobutylphenyl)butyric acid; Benzeneacetic acid,α-ethyl-4-(2-methylpropyl)-. Grade: 95%. CAS No. 55837-18-8. Molecular formula: C14H20O2. Mole weight: 220.31. | |
| Butlerin A | Butlerin A is an intriguing natural compound discovered in select plant species, holding great promise in studying diverse forms of cancer such as breast, liver and lung cancer. CAS No. 164124-63-4. Molecular formula: C24H24O6. Mole weight: 408.44. | |
| Butlerin B | Butlerin B, a cutting-edge biomedical compound, presents an unparalleled research breakthrough against the pernicious malaise of cancer. CAS No. 164124-64-5. Molecular formula: C24H24O6. Mole weight: 408.44. | |
| Butlerin C | Butlerin C is an innovative biomedical compound exhibiting its formidable prowess in studying an extensive repertoire of unparalleled malignancies. CAS No. 164124-65-6. Molecular formula: C25H24O7. Mole weight: 436.45. | |
| Butocarboxim | Butocarboxim is an acetylcholinesterase inhibitor used as a pesticide. Synonyms: 2-Butanone, 3-(methylthio)-, O-[(methylamino)carbonyl]oxime; Drawin 755. CAS No. 34681-10-2. Molecular formula: C7H14N2O2S. Mole weight: 190.27. | |
| Butoconazole Impurity 1 | an impurity of butoconazole. Synonyms: 1-Chloro-4-(4-chlorophenyl)-2-butanol; Benzenepropanol, 4-chloro-a-(chloroMethyl)- (Butoconazole interMediate). Grade: > 95%. CAS No. 59363-13-2. Molecular formula: C10H12Cl2O. Mole weight: 219.11. | |
| Butoconazole Impurity 2 | an impurity of butoconazole. Synonyms: 4-(4-Chloro-phenyl)-1-imidazol-1-yl-(butan-d5)-2-ol; 1-[4-(4-Chlorophenyl)-2-hydroxy-n-butyl]imidazole-d5. Grade: > 95%. CAS No. 67085-11-4. Molecular formula: C13H15ClN2O. Mole weight: 250.73. | |
| Butoconazole Impurity 3 | an impurity of butoconazole. Synonyms: 1-(2-CHLORO-4-(4-CHLOROPHENYL)BUTYL)-1H-IMIDAZOLE; INTERMEDIATE:BUTOCONAZOLENITRATE. Grade: > 95%. CAS No. 67085-12-5. Molecular formula: C13H14Cl2N2. Mole weight: 269.18. | |
| Butoconazole Impurity 4 | an impurity of butoconazole. Synonyms: 1H-Imidazole, 1-[2-chloro-4-[4-[(2,?6-dichlorophenyl)?thio]?phenyl]?butyl]?-. Grade: > 95%. CAS No. 1850278-18-0. Molecular formula: C19H17Cl3N2S. Mole weight: 411.78. | |
| Butoconazole Impurity 6 | an impurity of butoconazole. Synonyms: Oxirane, 2-[2-(4-chlorophenyl)?ethyl]?-. Grade: > 95%. CAS No. 59363-17-6. Molecular formula: C10H11ClO. Mole weight: 182.65. | |
| Butoconazole Impurity 9 | an impurity of butoconazole. Synonyms: Benzene, 1-chloro-4-(4-chloro-2-butenyl)-. Grade: > 95%. CAS No. 98011-62-2. Molecular formula: C10H10Cl2. Mole weight: 201.1. | |
| Butoconazole Nitrate | Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. Uses: Antifungal agents. Synonyms: Butoconazole, Gynazole-1, Mycelex-3, RS35887, RS-35887, RS 35887; Butoconazole Nitrate. Grade: >98%. CAS No. 64872-77-1. Molecular formula: C19H17Cl3N2S·HNO3. Mole weight: 474.79. | |
| Butyl 2-acetamido-2-deoxy-b-D-glucopyranoside | Butyl 2-acetamido-2-deoxy-b-D-glucopyranoside, a prominent compound in the biomedical industry, serves diverse purposes. Its invaluable role lies in the synthesis of potential drug candidates, specifically catering to ailments like cancer and infectious diseases. This compound's distinctive characteristics render it indispensable for the advancement of targeted therapeutics and drug delivery systems, thereby revolutionizing the realm of biomedical research and development. CAS No. 94536-61-5. Molecular formula: C12H23NO6. Mole weight: 277.31. | |
| Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside | Butyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside, a highly esteemed biomedicine renowned for its remarkable pharmaceutical attributes, serves as an invaluable asset in addressing an extensive array of afflictions. Widely acknowledged for its unmatched efficacy in countering antibiotic-resistant bacterial infections and ameliorating the impact of neurodegenerative disorders, this compound stands as a prominent component within anti-infective medications. Synonyms: Butyl 2-acetamido-3,4,6-tri-o-acetyl-beta-d-glucopyranoside. CAS No. 155197-37-8. Molecular formula: C18H29NO9. Mole weight: 403.42. | |
| Butyl 4-aminobenzoate | Butyl 4-aminobenzoate acts as a long-duration local anesthetic. It aids in treatment of chronic pain. It is also known to induce anti-nociception effects in subjects. It has been listed. Uses: Butyl 4-aminobenzoate acts as a long-duration local anesthetic. it aids in treatment of chronic pain. Synonyms: 4-(Butoxycarbonyl)aniline; 4-Amino-benzoicacibutylester; Benzoic acid, 4-amino-, butyl ester; Benzoic acid, p-amino-, butyl ester; Butesin; Butesine; Butsein; Butyl aminobenzoate N-butyl p-aminobenzoate; Butamben. Grade: 98%. CAS No. 94-25-7. Molecular formula: C11H15NO2. Mole weight: 193.24. | |
| butyl 4-methylbenzenesulfonate | Butyl p-Toluenesulfonate (CAS# 778-28-9) is used in preparation of highly-branched chain Ammonium Dicarboxylate Salt. Synonyms: Butyl 4-Toluenesulfonate. CAS No. 778-28-9. Molecular formula: C11H16O3S. Mole weight: 228.31. | |
| Butyl a-D-glucopyranoside | Butyl α-D-glucopyranoside stands out as a versatile carbohydrate derivative extensively employed in the field of biomedicine. Functioning as a non-ionic surfactant, it holds significant importance for its role in enhancing solubility and stability in drug formulations. The diverse range of applications of this product includes drug delivery systems, biotechnological explorations, and pharmaceutical analysis. Its efficacy in enhancing the therapeutic potential of drugs renders it invaluable in the treatment of numerous ailments, encompassing cancer, diabetes, and neurodegenerative disorders. CAS No. 25320-93-8. Molecular formula: C10H20O6. Mole weight: 236.26. | |
| Butyl b-D-glucopyranoside | Butyl b-D-glucopyranoside, a widely recognized biomedical product, showcases remarkable potential as a stabilizing agent within the realms of pharmaceutical and biochemical research. Its primary application revolves around the isolation and purification of imperative membrane proteins, including enzymes and receptors. These exceptionally crucial proteins hold the key to combating an array of diseases such as cancer and neurological disorders. Synonyms: Beta-D-Glucopyranoside, Butyl; n-butyl beta-D-glucopyranoside. CAS No. 5391-18-4. Molecular formula: C10H20O6. Mole weight: 236.26. | |
| Butyl-γ-cyclodextrin | Butyl-γ-cyclodextrin. Synonyms: Butyl-gamma-cyclodextrin. Molecular formula: C52H88O40. Mole weight: 1353.2. | |
| Butyrolactone II | Butyrolactone II is an antibiotic and it is weak cytotoxic towards bacterial and cancer cell lines. It is also a 5-Lipoxygenase (5-LOX) inhibitor and has shown DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavening activity. Synonyms: (2R)-2,5-Dihydro-4-hydroxy-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-5-oxo-2-furancarboxylic Acid Methyl Ester. Grade: >95%. CAS No. 87414-44-6. Molecular formula: C19H16O7. Mole weight: 356.33. | |
| Butyrolactone V | Butyrolactone V is a fungal metabolite that is produced by A. terreus and it has antiprotozoal, antioxidant, and anticancer activities. It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM). Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 μM, respectively). Synonyms: (2R)-2-[[(3S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]methyl]-2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-5-oxo-2-Furancarboxylic acid, methyl ester. Grade: >95% by HPLC. CAS No. 1151509-01-1. Molecular formula: C24H24O8. Mole weight: 440.44. | |
| Butyryl coenzyme A lithium salt | Butyryl coenzyme A lithium salt. Grade: 95%. CAS No. 102282-28-0. Molecular formula: C25H39Li3N7O17P3S. Mole weight: 855.423. | |
| Butyryl-L-carnitine chloride | (R)-Butyryl Carnitine is a potential prodrug of Carnitine, via the carnitine transporter OCTN2 and the amino acid transporter ATB0,+. It is an inhibitor of intestinal transporters, which block carnitine uptake by the carnitine transporter with IC50s of 1.5 μM and glycine transport with IC50s of 4.6 μM in in human retinal pigment epithelial (HRPE) cells. Butyryl-L-carnitine is used for treating seizure disorders. Synonyms: L-Butyrylcarnitine; C4 Carnitine. Grade: ≥95%. CAS No. 162067-50-7. Molecular formula: C11H22NO4·Cl. Mole weight: 267.8. | |
| Bvdv-IN-1 | BVDV-IN-1, a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV) (EC50 = 1.8 μM), has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC). It directly binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp), and inhibits the replication of TSC-resistant BVDV variants in vitro. Synonyms: BVDV-IN-1; 345651-04-9; 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol; 2-(4-(2-Phenylquinazolin-4-yl)piperazin-1-yl)ethanol; EX-A5593; AKOS000915262; MS-25053; HY-131976; CS-0145660; G13690. Grade: ≥98%. CAS No. 345651-04-9. Molecular formula: C20H22N4O. Mole weight: 334.41. | |
| BVT-14225 | BVT-14225 is a highly selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor(IC50 = 52 nM), which is 1,000 fold lower than that for 11β-HSD2. Synonyms: 2-[2-[(3-chloro-2-methylphenyl)sulfonylamino]-1,3-thiazol-4-yl]-N,N-diethylacetamide; BVT-14225; BVT 14225; BVT14225. CAS No. 376638-65-2. Molecular formula: C16H20ClN3O3S2. Mole weight: 401.93. | |
| BVT 2733 | BVT 2733 is a non-steroidal small molecule as a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC = 96 ± 14 nM). Synonyms: BVT-2733; BVT 2733; BVT2733; 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide; Piperazine, 1-((2-(((3-chloro-2-methylphenyl)sulfonyl)amino)-4-thiazolyl)acetyl)-4-methyl-. Grade: 98%. CAS No. 376640-41-4. Molecular formula: C17H21ClN4O3S2. Mole weight: 428.95. | |
| BVT 2733 hydrochloride | BVT 2733 hydrochloride is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1. Synonyms: BVT 2733 hydrochloride; BVT2733 hydrochloride; BVT-2733 hydrochloride; 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride. Grade: 99%. CAS No. 376641-65-5. Molecular formula: C17H21ClN4O3S2.HCl. Mole weight: 465.42. | |
| BVT-948 | BVT 948 is a non-competitive and cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM). BVT 948 displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP, and enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Some cytochrome P450 isoforms are also suppressed by BVT 948 (IC50 <10 μM). Synonyms: BVT948; BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione. Grade: ≥98% by HPLC. CAS No. 39674-97-0. Molecular formula: C14H11NO3. Mole weight: 241.24. | |
| BW 245C | BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1) agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM and has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation. Synonyms: 7-[(4S)-3-[(3R)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxoimidazolidin-4-yl]heptanoic acid; 245C77; 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin; BW 245C; BW 245C, (R*,S*)-(+-); BW-245C. CAS No. 72814-32-5. Molecular formula: C19H32N2O5. Mole weight: 368.47. | |
| BW 246C | The prostaglandin D2 (PGD2) receptors are the members of G protein-coupled receptors. PGD2 receptors include the following proteins prostaglandin D2 receptor 1 (DP1) and prostaglandin D2 receptor 2 (DP2). BW 246C is a DP receptor agonist. BW 246C is the less active C-8 diastereomer of the DP receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C. Synonyms: 8-epi BW 245C. Grade: ≥98%. CAS No. 65705-83-1. Molecular formula: C19H32N2O5. Mole weight: 368.5. | |
| BW 373U86 | BW 373U86 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 1.8, 15 and 34 nM for δ, μ and κ receptors, respectively). Synonyms: BW-373U86; SNC-86; BW 373U86; SNC 86; BW373U86; SNC86; 4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide. Grade: ≥99% by HPLC. CAS No. 155836-50-3. Molecular formula: C27H37N3O2. Mole weight: 435.61. | |
| BW 723C86 hydrochloride | BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist used for the treatment of certain CNS disorders, such as epilepsy, migraine and feeding disorders. Uses: The treatment of cns disorders as epilepsy, migraine and feeding disorders. Synonyms: BW723C86; BW-723-C-86; BW 723 C 86; BW-723C86; BW 723C86; α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride. Grade: ≥99% by HPLC. CAS No. 160521-72-2. Molecular formula: C16H18N2OS.HCl. Mole weight: 322.85. | |
| BW 755C | Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grade: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20. | |
| BW-A78U | BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U fails to significantly inhibit arachidonate release. It is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-α release. Synonyms: BW A78U. Grade: ≥98%. CAS No. 101155-02-6. Molecular formula: C13H12FN5. Mole weight: 257.27. | |
| BW A868C | Prostaglandin D2 (PGD2) has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system. BW A868C is a novel, selective and potent competitive antagonist of PGD2. BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. However, it has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Synonyms: BWA-868C; BWA868C. Grade: ≥98%. CAS No. 118675-50-6. Molecular formula: C25H37N3O5. Mole weight: 459.6. | |
| BW-B 70C | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-α. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grade: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
| BWX 46 Acetate | BWX 46 Acetate is a potent, highly selective neuropeptide Y (NPY) receptor agonist with IC50 of 0.5 nM. Synonyms: ((Cys31,Nva34)-NPY (27-36))2 Acetate. Molecular formula: C118H190N36O30S2. Mole weight: 2657.12. | |
| BX-320 | BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC50 = 30 nM). BX-320 also induces apoptosis. Synonyms: BX320; N-(3-(4-(3-(3-amino-2,2-dimethyl-3-oxopropanamido)propylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide. CAS No. 702676-93-5. Molecular formula: C23H31BrN8O3. Mole weight: 547.45. | |
| BX341 | BX341, also known as bifluranol, is a new fluorinated bibenzyl anti-androgen and one of a series of bibenzyls designed to present some of the hormonal properties of diethylstilboestrol (DES) but with a lower potential for toxicity. Synonyms: BX341; BX 341; BX-341; 2-fluoro-4-[3-(3-fluoro-4-hydroxyphenyl)pentan-2-yl]phenol; bifluranol; erythro-2,3-bis(3-fluor-4-hydroxyphenyl)pentan. CAS No. 34633-34-6. Molecular formula: C17H18F2O2. Mole weight: 292.32. | |
| BX 430 | BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM) binding noncompetitively to extracellular allosteric site. It exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. BX 430 is inactive at mouse and rat P2X4 receptors. Synonyms: BX430; BX-430; BX 430; N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea. Grade: ≥99% by HPLC. CAS No. 688309-70-8. Molecular formula: C15H15Br2N3O. Mole weight: 413.11. | |
| BX 471 | BX 471 is a selective CCR1 antagonist. Synonyms: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea; BX471; BX 471; BX-471; ZK811752; ZK 811752; ZK-811752. CAS No. 217645-70-0. Molecular formula: C21H24ClFN4O3. Mole weight: 434.89. | |
| BX471 hydrochloride | BX471 hydrochloride is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Synonyms: BX-471 hydrochloride; BX 471 hydrochloride; (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea hydrochloride. CAS No. 288262-96-4. Molecular formula: C21H25Cl2FN4O3. Mole weight: 471.35. | |
| BX 513 | BX 513 is a selective CCR1 receptor antagonist and a full inverse agonist of the HCMV-encoding chemokine receptor US28. It inhibits MIP-1α-induced intracellular calcium mobilization. Synonyms: 1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-; 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile; VUF 2274; 5-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrile; BX-513; BX513. Grade: ≥95%. CAS No. 193542-65-3. Molecular formula: C28H29ClN2O. Mole weight: 445.00. | |
| BX-513 hydrochloride | BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki = 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors, respectively), and also acts as a US28 agonist. It inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Synonyms: BX 513 hydrochloride; 193542-65-3; 1216540-18-9; BX-513 HCl; BX513Hydrochloride; VUF 2274; BX-513; 5-[4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDIN-1-YL]-2,2-DIPHENYLPENTANENITRILE HYDROCHLORIDE; 5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile; hydrochloride; BX-513 hydrochloride; 4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE; BX 513 HCL; DTXSID30719335; BCP27909; AKOS024457285; AS-57268; VUF 2274; VUF2274; BX513 hydrochloride; BX-513 hydrochloride; 1-Piperidinepentanenitrile,4-(4-chlorophenyl)-4-hydroxy-a,a-diphenyl-,HCl; 5-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile--hydrogen chloride (1/1). Grade: ≥99% by HPLC. CAS No. 1216540-18-9. Molecular formula: C28H30Cl2N2O. Mole weight: 481.46. | |
| BX-517 | BX-517, also known as PDK1 inhibitor2, is a cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDK1 inhibitor (IC50 = 6 nM). BX-517 also blocks activation of Akt in tumor cells with 10-fold more potent (IC50 = 0.1-1.0 μM) than its analogs tested at the highest dose tested (10 μM). Synonyms: (Z)-N-(3-(1-(1H-pyrrol-2-yl)ethylidene)-2-hydroxy-3H-indol-5-yl)carbamimidic acid; BX-517; BX 517; BX517; PDK1 inhibitor2. CAS No. 850717-64-5. Molecular formula: C15H14N4O2. Mole weight: 282.3. | |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Synonyms: BX 795; BX795. Grade: ≥98%. CAS No. 702675-74-9. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. | |
| BX 795 hydrochloride | BX 795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. Synonyms: N-(3-(5-Iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide hydrochloride. Grade: 98%. CAS No. 1472611-45-2. Molecular formula: C23H26IN7O2S.HCl. Mole weight: 627.93. | |
| BX912 | BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. Synonyms: BX912; BX 912; BX-912. Grade: 0.98. CAS No. 702674-56-4. Molecular formula: C20H23BrN8O. Mole weight: 471.363. | |
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