BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BP 897 hydrochloride | BP 897 hydrochloride, a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist, has a high affinity for the dopamine D3 receptor (Ki = 0.92 nM) and a 70 times lower affinity for the D2 receptor (Ki = 61 nM). It shows selective inhibition of cocaine-seeking behavior. Uses: Dopamine agonists. Synonyms: 2-Naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-, monohydrochloride; N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride; N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide hydrochloride (1:1). Grade: ≥95%. CAS No. 314776-92-6. Molecular formula: C26H32ClN3O2. Mole weight: 454.00. |  |
| BPD-Ring B | BPD-Ring B is a product from the synthesis of verteporfinin. It can be used for making porphyrin-related dye, nanoparticles, photosensitizers, and other photodymanic therapeutic drugs. Uses: Make porphyrin-related dye, nanoparticles, photosensitizers, and other photodymanic therapeutic drugs. Synonyms: BPD-B; Benzoporpyrin Ring B derivative; 23H,25H-Benzo[b]porphine-9,13- dipropanoic acid, 19-ethenyl-1,22a-dihydro-1,2-bis(methoxycarbonyl)-8,14,18, 22a-tetramethyl-, dimethyl ester. Grade: 98%. CAS No. 143986-17-8. Molecular formula: C42H44N4O8. Mole weight: 732.83. | |
| BPH-1358 | BPH-1358 is a potent inhibitor of human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) with IC50s of 1.8 μM and 110 nM, respectively. It has activity against Staphylococcus aureus in vitro (MIC ~250 ng/mL). Synonyms: TS-07705; HY-118946. CAS No. 5352-53-4. Molecular formula: C32H30Cl2N6O2. Mole weight: 601.5. | |
| BPH-1358 free base | BPH-1358 free base is a potent inhibitor of human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) with IC50s of 1.8 μM and 110 nM, respectively. It has activity against Staphylococcus aureus in vitro (MIC ~250 ng/mL). Synonyms: NSC 50460 free base; N,N'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]biphenyl-4,4'-dicarboxamide; N,N'-Bis[3-(4,5-dihydro-1H-imidazole-2-yl)phenyl]-1,1'-biphenyl-4,4'-dicarboxamide; [1,1'-Biphenyl]-4,4'-dicarboxamide, N4,N4'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-; N,N'-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4,4'-biphenyldicarboxamide. Grade: ≥95%. CAS No. 801985-13-7. Molecular formula: C32H28N6O2. Mole weight: 528.60. | |
| BPH-1358 mesylate | BPH-1358 mesylate is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. BPH-1358 mesylate is active against S. aureus in vitro (MIC ~250 ng/mL). Synonyms: NSC50460 mesylate. Molecular formula: C34H36N6O8S2. Mole weight: 720.82. | |
| BPH-652 | BPH-652, also known as BMS-187745, has been found to be a SQS inhibitor that could probably be effective against S. aureus infections. Synonyms: BMS-187745; BPH-652; BMS 187745; BPH 652; BMS187745; BPH652; CHEMBL351151; BMS 188745 Potassium Salt; DNC009027; KB-75764; tripotassium; 4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate. Grade: 98%. CAS No. 157124-84-0. Molecular formula: C16H16K3O7PS. Mole weight: 500.63. | |
| BPH715 | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium; Bisphpshonate-715; [2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate; Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grade: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. | |
| BPI-9016M | BPI-9016M, a potent, orally active and selective dual c-Met and AXL tyrosine kinase inhibitor, inhibits lung adenocarcinoma tumor cell growth, migration and invasion. Synonyms: N-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxamide; 3-Pyridinecarboxamide, N-[4-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-. Grade: ≥95%. CAS No. 1528546-94-2. Molecular formula: C25H18F2N4O3. Mole weight: 460.43. | |
| bPiDDB | bPiDDB is a neuronal nicotinic acetylcholine receptor (AChR) antagonist with IC50s of 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1γδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors, respectively. Synonyms: Pyridinium, 1,1'-(1,12-dodecanediyl)bis[3-methyl-, bromide (1:2); Pyridinium, 1,1'-(1,12-dodecanediyl)bis[3-methyl-, dibromide; 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide; N,N'-Dodecylbis-Picolinium Bromide; N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide; 1,1'-(Dodecane-1,12-diyl)bis(3-methylpyridin-1-ium) bromide; BPiDDB. Grade: ≥95%. CAS No. 525596-66-1. Molecular formula: C24H38Br2N2. Mole weight: 514.38. | |
| BPIPP | BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It downregulates cAMP and cGMP synthesis, suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM), inhibits GC-stimulated Cl- transport in vitro, and suppresses toxin-induced intestinal fluid accumulation in vivo. BPIPP may be a useful treatment of diarrhea. Uses: Potential treatment of diarrhea. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione. Grade: ≥99% by HPLC. CAS No. 325746-94-9. Molecular formula: C22H16BrN3O3. Mole weight: 450.28. | |
| BPIQ-I | BPIQ-I is an extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 25 pM. It can inhibit the growth of SKOV3 and MDA-468 tumor cell lines with EC50 values of 6.5 and 30 μM, respectively. Uses: Protein kinase inhibitors. Synonyms: PD 159121. Grade: ≥95%. CAS No. 174709-30-9. Molecular formula: C16H12BrN5. Mole weight: 354.2. | |
| BPIQ-II hydrochloride | BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with IC50 of 8 pM. It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR. Synonyms: PD 158294. Grade: ≥98%. CAS No. 171179-37-6. Molecular formula: C15H10BrN5·HCl. Mole weight: 376.6. | |
| BPK-29 | BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. Synonyms: BPK 29; BPK29. Grade: 98% by HPLC. CAS No. 2143467-62-1. Molecular formula: C26H32ClN3O3. Mole weight: 470.0. | |
| BPKDi | BPKDi is an inhibitor of protein kinase D with IC50 of 1, 9, and 1 nM for PKD1, PKD2 and PKD3, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells. Synonyms: bipyridyl PKD inhibitor; 2'-(Cyclohexylamino)-6-(piperazin-1-yl)-2,4'-bipyridine-4-carboxamide. Grade: 99%. CAS No. 1201673-28-0. Molecular formula: C21H28N6O. Mole weight: 380.49. | |
| BPN-15606 besylate | BPN-15606 besylate is a highly potent and orally active γ-secretase modulator (GSM) with acceptable PK/PD properties, including bioavailability, half-life and clearance. It attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50s of 7 and 17 nM, respectively. It decreases the level of Aβ42 and Aβ40 in the central nervous system of rats and mice. Synonyms: N-[(1S)-1-(4-Fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-4-methyl-3-pyridazinamine benzenesulfonate (1:1); 3-Pyridazinamine, N-[(1S)-1-(4-fluorophenyl)ethyl]-6-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-4-methyl-, benzenesulfonate (1:1). Molecular formula: C29H29FN6O4S. Mole weight: 576.64. | |
| BPO-27 racemate | BPO-27 racemate inhibited CFTR with IC50 ? 8 nM and had greatly improved in vitro metabolic stability and aqueous solubility compared to PPQ-102. Synonyms: BPO-27 (racemate); BPO 27 racemate; BPO27 racemate; BPO-27 racemate; CHEMBL1831075; CHEMBL 1831075; CHEMBL-1831075; BPO-27 racemat. CAS No. 1314873-02-3. Molecular formula: C26H18BrN3O6. Mole weight: 548.34. | |
| BPR1J-097 | BPR1J-097 is a novel potent FLT3 inhibitor with an IC50 of 11?nM. Synonyms: BPR1J097; BPR1J-097; BPR1J 097; BPR1-J097; BPR1 J097; BPR1J097. Grade: >98%. CAS No. 1327167-19-0. Molecular formula: C27H28N6O3S. Mole weight: 516.62. | |
| BPR1J-097 hydrochloride | BPR1J-097 hydrochloride is a potent inhibitor of FLT3 (IC50 = 11 nM) with great anti-tumor activities in vivo. Synonyms: 4-(4-Methyl-1-piperazinyl)-N-(5-{3-[(phenylsulfonyl)amino]phenyl}-1H-pyrazol-3-yl)benzamide hydrochloride (1:1); Benzamide, 4-(4-methyl-1-piperazinyl)-N-[5-[3-[(phenylsulfonyl)amino]phenyl]-1H-pyrazol-3-yl]-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C27H29ClN6O3S. Mole weight: 553.08. | |
| BPR1J-340 | BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD(+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Synonyms: BPR1J 340; BPR1J340. Grade: 98%. CAS No. 1395051-72-5. Molecular formula: C29H34N8O3. Mole weight: 542.63. | |
| BPR1K653 | SBPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent activity against the growth of xenograft tumors of the human cervical carcinoma KB and KB-derived MDR1-positive KB-VIN10 cells in nude mice. Finally, BPR1K653 also exhibited favorable pharmacokinetic properties in rats., BPR1K653 is a promising anti-cancer compound that has potential for the management of various malignancies, particularly for patients with MDR1-related drug resistance after prolonged chemotherapeutic treatments. Synonyms: BPR1K653; BPR1K 653; BPR1K-653. Grade: 98%. CAS No. 1192754-07-6. Molecular formula: C30H30Cl2N6O2. Mole weight: 541.04. | |
| BPR1M97 | BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist (Kis: 1.8 and 4.2 nM) with blood-brain barrier penetration. It produces potent antinociceptive effects. Synonyms: 3,4-Dichloro-N-[(1,2,3,4-tetrahydro-2-methyl-1-isoquinolinyl)methyl]benzamide. Grade: 98%. CAS No. 2059904-66-2. Molecular formula: C18H18Cl2N2O. Mole weight: 349.25. | |
| BPR1R024 | BPR1R024 is a selective and orally active colony stimulating factor-1 receptor (CSF1R) inhibitor with an IC50 of 0.53 nM. Synonyms: Urea, N-[4-[[7-(dimethylamino)-4-quinazolinyl]oxy]phenyl]-N'-[[6-(trifluoromethyl)-3-pyridinyl]methyl]-. CAS No. 2503015-75-4. Molecular formula: C24H21F3N6O2. Mole weight: 482.46. | |
| BPTES | BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. Grade: 98%. CAS No. 314045-39-1. Molecular formula: C24H24N6O2S3. Mole weight: 524.68. | |
| BPTF-IN-BZ1 | BPTF-IN-BZ1 is a BPTF inhibitor with high potency (Kd = 6.3 nM). Synonyms: 5-((4-(2-aminoethyl)phenyl)amino)-4-chloro-2-methylpyridazin-3(2H)-one. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
| BPTU | BPTU is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM) that binds receptors outside of the helical bundle. BPTU blocks inhibition of spontaneous contraction of rat and mouse colon, which is induced by electrical field activation, nicotine and P2Y agonists. It exhibits antithrombotic activity and reduces platelet aggregation. Uses: Antithrombotic. Synonyms: BPTU; BMS-646786; BMS 646786; BMS646786; BMS compound 16; N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea. Grade: ≥98% by HPLC. CAS No. 870544-59-5. Molecular formula: C23H22F3N3O3. Mole weight: 445.43. | |
| BPU-11 | BPU-11 is a HCN4 CLP ligand. It acts by modulating channel function and completely abolishing the cAMP-induced shift in V1/2. Synonyms: Biphenyl Urea 11. Grade: >98%. CAS No. 909664-41-1. Molecular formula: C32H31N5O. Mole weight: 501.62. | |
| bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. It is reported to function as an insulin mimetic and activate the insulin receptor kinase (IRK). BpV(HOpic) has been shown to activate the insulin receptor kinase of hepatoma cells and enhance PI3K/Akt signaling, which could prevent ischemia-reperfusion (I/R) injury to the myocardium. Synonyms: Bisperoxovanadium(HOpic). Grade: ≥95%. CAS No. 722494-26-0. Molecular formula: C6H4NO8V·2K. Mole weight: 347.2. | |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grade: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| bpV(pic) potassium hydrate | BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium. It is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 31 nM. It is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells and stimulating lipogenesis in adipocytes. BpV(pic) has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells and is also an inhibitor of G6Pase. Synonyms: Bisperoxovanadium(pic). Grade: ≥96%. CAS No. 148556-27-8. Molecular formula: C6H4NO7V·2K·2H2O. Mole weight: 367.3. | |
| BQCA | BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1 receptor. Uses: A highly selective positive allosteric modulator of the m1 muscarinic acetylcholine receptor (machr). Synonyms: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic Acid. Grade: ≥98%. CAS No. 338747-41-4. Molecular formula: C18H15NO4. Mole weight: 309.32. | |
| BQR695 | BQR695 is a potent and selective PI4K inhibitor exhibiting potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC50?values of 90?nM and 71 nM, respectively). Uses: Antimalarial. Synonyms: NVP-BQR695; NVP-BQR-695; NVP-BQR 695; BQR695; BQR-695; BQR 695. NVP-BQR695; CS-8070; HY-18748; CS 8070; HY 18748; CS8070; HY18748; 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide. Grade: 99%. CAS No. 1513879-21-4. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Synonyms: BQU57; BQU 57; BQU-57. Grade: >98%. CAS No. 1637739-82-2. Molecular formula: C16H13F3N4O. Mole weight: 334.1. | |
| BR-103354 | BR-103354 is a fibroblast activation protein (FAP) inhibitor with IC50 of 14 nM. BR-103354 functions as an anti-diabetic and anti-NASH agent. Synonyms: BR 103354; BR103354. Grade: >98%. CAS No. 2505339-87-5. Molecular formula: C19H15F2N5O2S. Mole weight: 415.42. | |
| Braco-19 | Braco-19 is a potent telomerase/telomere inhibitor that prevents telomerase catalysis. Braco-19, as a G-quadruplex (GQ) binding ligand, stabilizes GQ formation at 3V telomeric DNA overhang and produces rapid senescence or selective cell death. It is also an HAdV virus replication inhibitor. Uses: Cytostatic agents. Synonyms: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide; N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide; 9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido)acridine. Grade: ≥95%. CAS No. 351351-75-2. Molecular formula: C35H43N7O2. Mole weight: 593.76. | |
| BRACO 19 trihydrochloride | BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM) that suppresses the expression of human telomerase reverse transcriptase (hTERT) and induces cellular senescence. BRACO 19 was shown to inhibit growth of uterine cancer cells in vitro and growth of uterine tumor xenografts in mice. Synonyms: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride. Grade: ≥95% by HPLC. CAS No. 1177798-88-7. Molecular formula: C35H43N7O2.3HCl. Mole weight: 703.14. | |
| Bractoppin | Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain. Bractoppin interrupts BRCA1 tBRCT-dependent cellular signals evoked by DNA damage. Bractoppin selectively inhibits substrate binding with nanomolar potency in vitro. Grade: 99%. CAS No. 2290527-07-8. Molecular formula: C25H23FN4O. Mole weight: 414.47. | |
| Bradanicline | Bradanicline acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was used as a potential treatment for schizophrenia and attention deficit disorder. It was used for Alzheimer's disease and cognitive impairment, but was discontinued. It was being developed by Targacept and was in phase II trials, but now it is terminated. Uses: Bradanicline was used as a potential treatment for schizophrenia and attention deficit disorder. it was used for alzheimer's disease and cognitive impairment. Synonyms: TC-5619; TC 5619; TC5619; N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide; TC-5619-023; TC5619-023. Grade: 98%. CAS No. 639489-84-2. Molecular formula: C22H23N3O2. Mole weight: 361.44. | |
| Bradanicline hydrochloride | Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potential treatment for schizophrenia and attention deficit disorder. It was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late 2013. It was also discontinued for ADHD, and no longer seems to be being developed. Uses: Bradanicline hydrochloride was being developed as a potential treatment for schizophrenia and attention deficit disorder. Synonyms: TC-5619; TC5619; TC-5619-023; TC5619-023; N-((2S,3R)-2-(pyridin-3-ylmethyl)quinuclidin-3-yl)benzofuran-2-carboxamide hydrochloride. Grade: >98%. CAS No. 1111941-90-2. Molecular formula: C22H24ClN3O2. Mole weight: 397.90. | |
| Bradykinin triacetate | Bradykinin triacetate is a non-peptide messenger that is enzymatically produced from KALLIDIN in the blood. It is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Synonyms: Bradykinin, acetate (1:3); Bradykinin, triacetate (salt); Arginine, N2-[N-[1-[N-[N-[N-[1-(1-L-arginyl-L-prolyl)-L-prolyl]glycyl]-3-phenyl-L-alanyl]-L-seryl]-L-prolyl]-3-phenyl-L-alanyl]-, triacetate; Bradykinin acetate; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH.3CH3CO2H; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine acetic acid. Grade: ≥95%. CAS No. 5979-11-3. Molecular formula: C50H73N15O11.3C2H4O2. Mole weight: 1240.38. | |
| B-Raf IN 1 | B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor. It was equipotent against c-Raf. Synonyms: B-Raf-IN-1; B-Raf-IN 1; B-Raf-IN1; MDK36057; MDK-36057; MDK 36057. Grade: >98%. CAS No. 950736-05-7. Molecular formula: C29H24F3N5O. Mole weight: 515.53. | |
| B-Raf IN 2 | B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. CAS No. 2649372-20-1. Molecular formula: C20H17F2N5O4S. Mole weight: 461.44. | |
| B-Raf inhibitor | aA B-Raf inhibitor, pyrazine and pyrrolo[2,3-b]pyridine derivatives, useful in the treatment of cancer and proliferative diseases. Synonyms: Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]-. Grade: >98%. CAS No. 1315330-11-0. Molecular formula: C29H31F3N6O2. Mole weight: 552.59. | |
| B-Raf inhibitor 1 | B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK respectively. Synonyms: B-Raf Inhibitor 1; B-Raf-Inhibitor 1; B-Raf-Inhibitor-1; MDK0403; MDK-0403; MDK 0403. Grade: >98%. CAS No. 1093100-40-3. Molecular formula: C26H19ClN8. Mole weight: 478.94. | |
| B-Raf inhibitor 1 dihydrochloride | B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grade: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86. | |
| Brain Natriuretic Peptide (1-32) (human) trifluoroacetate salt | Brain natriuretic peptide (BNP) (1-32) is an endogenous peptide that has cardiovascular functions and belongs to the family of natriuretic peptides. It is an agonist of natriuretic peptide receptors (NPRs) 1 and 3 with Kd values of 7.3 and 13 pM, respectively. It also binds to human recombinant NPR1 and NPR3 with IC50 values of 8 and 2.6 nM, respectively. It also relaxes contractions induced by prostaglandin F2α (PGF2α) in isolated porcine coronary artery and rat aortic strips (IC50s = 0.02 and 12.1 nM, respectively). Synonyms: BNP (1-32) (human). Grade: ≥95%. Molecular formula: C143H244N50O42S4·xCF3COOH. Mole weight: 3464.04. | |
| Br-ANT-ATP | Br-ANT-ATP is an analogue of adenosine-5'-triphosphate, of which the intrinsic fluorescence would increase in hydrophobic environment. It can be used for research into ATP-dependent receptor proteins. Synonyms: 2'- / 3'- O- (5- Bromoanthraniloyl)adenosine- 5'- O- triphosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 1350521-49-1. Molecular formula: C17H20BrN6O14P3 (free acid). Mole weight: 705.2 (free acid). | |
| Brasofensine | Brasofensine is a phenyltropane drug that is developed for the treatment of Parkinson's and Alzheimer's disease. Synonyms: NS-2214; BMS-204756; (E)-1-[(2R,3S)-3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-N-methoxymethanimine. CAS No. 171655-91-7. Molecular formula: C16H20Cl2N2O. Mole weight: 327.249. | |
| Brassinazole | Brassinazole is a potent brassinosteroid (BR) biosynthesis inhibitor that has similar structure to pacrobutrazol. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. It has displayed the ability to induce morphological changes in dark-grown Arabidopsis. It can also induce morphological changes, including dwarfism and altered leaf color and curling. Synonyms: Brassinazole. Grade: ≥98%. CAS No. 224047-41-0. Molecular formula: C18H18ClN3O. Mole weight: 327.8. | |
| Brassinin | Brassinin is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 28 μM for human IDO) with antifungal and anticancer activities. Brassinin also inhibits IL-6-inducible STAT3 activation and attenuates tumor growth in a xenograft lung cancer mouse model. Brassinin is found in brassicas. Synonyms: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778; Methyl (1H-indol-3-ylmethyl)carbamodithioate. Grade: 98%. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.36. | |
| BRCA1-IN-1 | A novel small-molecule-like BRCA1 inhibitor (IC50= 0.53 μM) (Ki= 0.71 μM). Synonyms: [(3S)-1,1-difluoro-3-[3-(1H-indol-3-yl)propanoylamino]-4-oxo-4-[[2-oxo-2-(4-phenylbutylamino)ethyl]amino]butyl]phosphonic acid. CAS No. 1622262-74-1. Molecular formula: C27H33F2N4O6P. Mole weight: 578.54. | |
| BRCA1-IN-2 | BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM. It shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions. Synonyms: N-(4-Phenylbutyl)-2-[[(2S)-2-[[3-(1H-indole-3-yl)propanoyl]amino]-3-(phosphonooxy)propanoyl]amino]acetamide. Grade: 98%. CAS No. 1622262-55-8. Molecular formula: C26H33N4O7P. Mole weight: 544.54. | |
| BRD0418 | BRD0418 is a TRIB1 inducer. BRD0418 modulates expression of TRIB1 involved in cholesterol and triglyceride biosynthesis, VLDL production and in LDL uptake in HepG2 cells. Synonyms: BRD-0418; BRD 0418. Grade: >98%. CAS No. 1565827-99-7. Molecular formula: C29H32N2O5. Mole weight: 488.58. | |
| BRD0539 | BRD0539 is a cell-permeable and reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 μM. Synonyms: BRD 0539; BRD-0539. CAS No. 1403838-79-8. Molecular formula: C25H25FN2O3S. Mole weight: 452.54. | |
| BRD0639 | BRD0639 is a first-in-class PRMT5 inhibitor. BRD0639 can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions. Synonyms: BRD 0639; BRD-0639; 1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)-; (αS)-4-Chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-1(6H)-pyridazineacetamide; (S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide. Grade: ≥95%. CAS No. 2760881-74-9. Molecular formula: C21H22ClN5O4S. Mole weight: 475.95. | |
| BRD0705 | BRD0705 is a potent, paralog selective and orally active inhibitor of Glycogen synthase kinase 3α (GSK3α) with IC50 of 66 nM and Kd of 4.8 μM. Synonyms: BRD 0705; BRD-0705. CAS No. 2056261-41-5. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| BRD32048 | The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grade: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period. Synonyms: 4-Acetylamino-N-(2-Amino-4-Fluorophenyl)-Benzamide; CHEMBL4293858; SCHEMBL15551809; BDBM178100. Grade: 98%. CAS No. 1550053-02-5. Molecular formula: C15H14FN3O2. Mole weight: 287.29. | |
| BRD3731 | BRD3731 is a selective inhibitor of GSK3β, with IC50s of 15 and 215 nM for GSK3β and GSK3α, respectively. It has potential for the study of post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes and neurodegenerative disorders. Synonyms: 5H-Pyrazolo[3,4-b]quinolin-5-one, 3-(2,2-dimethylpropyl)-1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-, (4S)-; (4S)-3-(2,2-Dimethylpropyl)-4,7,7-trimethyl-4-phenyl-1,2,4,6,7,8-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one. Grade: ≥98%. CAS No. 2056262-07-6. Molecular formula: C24H31N3O. Mole weight: 377.52. | |
| BRD 4354 | BRD 4354 is an HDAC5 and HDAC9 inhibitor (IC50 = 0.85 and 1.88 μM, respectively) displaying >20-fold selectivity for HDAC5/9 over HDAC1/2/3. It also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Synonyms: BRD4354; BRD 4354; BRD-4354; 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol. Grade: ≥98% by HPLC. CAS No. 315698-07-8. Molecular formula: C21H23ClN4O. Mole weight: 382.89. | |
| BRD 4354 ditrifluoroacetate | BRD 4354 ditrifluoroacetate is a moderately potent HDAC5 and HDAC9 inhibitor with IC50s of 0.85 and 1.88 μM, respectively. Synonyms: 8-Quinolinol, 5-chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-, 2,2,2-trifluoroacetate (1:2); 5-Chloro-7-[(4-ethyl-1-piperazinyl)(3-pyridinyl)methyl]-8-quinolinol trifluoroacetate (1:2). CAS No. 2444837-63-0. Molecular formula: C25H25ClF6N4O5. Mole weight: 610.93. | |
| BRD4770 | BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology. Synonyms: BRD4770; BRD-4770; BRD 4770. Grade: 0.98. CAS No. 1374601-40-7. Molecular formula: C25H23N3O3. Mole weight: 413.477. | |
| BRD4884 | BRD4884 is a selective HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3. It possesses preferential binding kinetics with seven-fold longer half-life. BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. It acts by enhancing the learning and memory processes. Synonyms: BRD-4884; BRD 4884. Grade: ≥98%. CAS No. 1404559-91-6. Molecular formula: C18H19FN2O2. Mole weight: 314.4. | |
| BRD4/CK2-IN-1 | BRD4/CK2-IN-1 is an effective and orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC). Molecular formula: C29H30ClN5O5. Mole weight: 564.03. | |
| BRD5018 | BRD5018 is an antimalarial agent. CAS No. 2245231-51-8. Molecular formula: C33H38N4O4. Mole weight: 554.68. | |
| BRD5648 | BRD5648 is the inactive enantiomer of rac-BRD0705, which is a potent, paralog selective and orally active inhibitor of GSK3α. Synonyms: (R)-BRD0705; (R)-4-Ethyl-7,7-dimethyl-4-phenyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-b]quinolin-5(4H)-one. Grade: 99%. CAS No. 2056261-42-6. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| BRD6688 | BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 μM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1. It crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration. Synonyms: BRD-6688; BRD 6688. Grade: ≥98%. CAS No. 1404562-17-9. Molecular formula: C16H18N4O. Mole weight: 282.3. | |
| BRD 6989 | BRD 6989 is a small molecule inhibitor with high selectivity for CDK8 over CDK19. It is an analog of the natural product cortistatin A (dCA), which inhibits CDK8 and upregulates IL-10. BRD 6989 selectively binds a complex of CDK8 with an IC50 of 200 nM. It also inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs. It may be useful for inflammatory disorders. Synonyms: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile; BRD-6989; BRD6989. Grade: ≥98%. CAS No. 642008-81-9. Molecular formula: C16H16N4. Mole weight: 264.33. | |
| BRD7116 | BRD7116 is an inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM) but does not affect normal hematopoietic stem cells or AML cells. Synonyms: BRD-7116; 2,2,3,3-tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide. Grade: >98%. CAS No. 329059-55-4. Molecular formula: C28H36N2O4S. Mole weight: 496.66. | |
| BRD 7389 | BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2, respectively). It upregulates insulin expression in mouse αTC1 pancreatic α cells. Synonyms: BRD7389; BRD-7389; BRD 7389; BAS 05532738; BAS05532738; BAS-05532738; 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione. Grade: ≥97% by HPLC. CAS No. 376382-11-5. Molecular formula: C24H18N2O2. Mole weight: 366.41. | |
| BRD73954 | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. Synonyms: BRD73954; BRD-73954; BRD 73954. Grade: >98%. CAS No. 1440209-96-0. Molecular formula: C16H16N2O3. Mole weight: 284.31. | |
Our database is helping our users find suppliers everyday.
