BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BLZ945 | BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC50 of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRb). Synonyms: sotuletinib; BLZ 945; BLZ-945. Grade: >98%. CAS No. 953769-46-5. Molecular formula: C20H22N4O3S. Mole weight: 398.48. |  |
| BM-1244 | BM-1244 is a potent Bcl-xL and Bcl-2 inhibitor with Kis of 134 and 450 nM, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (Extracted from patent WO2019033119A1). Synonyms: 4-Piperidinecarboxylic acid, 1-[(3R)-3-[[4-[[[4-[4-[3-[2-(4-chlorophenyl)-5-methyl-1-(1-methylethyl)-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl]-1-piperazinyl]phenyl]amino]sulfonyl]-2-[(trifluoromethyl)sulfonyl]phenyl]amino]-4-(phenylthio)butyl]-; 1-[(3R)-3-[(4-{[4-(4-{3-[2-(4-Chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl}-1-piperazinyl)phenyl]sulfamoyl}-2-[(trifluoromethyl)sulfonyl]phenyl)amino]-4-(phenylsulfanyl)butyl]-4-piperidinecarboxylic acid. Grade: ≥98%. CAS No. 1619923-32-8. Molecular formula: C54H59ClF4N6O8S4. Mole weight: 1159.79. | |
| BM152054 | BM152054, a thiazolidinedione, revealed to be potent PPARg-activators in transient transfection assays in vitro. Synonyms: BM152054; BM 152054; BM-152054; 5-[[4-[2-(5-methyl-2-thiophen-2-yl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione; BM 15.2054; BM-15.2054; BM15.2054. CAS No. 213411-84-8. Molecular formula: C22H18N2O4S3. Mole weight: 470.58. | |
| BM-212 | BM-212, a piperazine derivative, has been found to be effective in restraining the mycobacteria and exhibit intracellular bactericidal activity at some extent. Uses: Anti-bacterial agents. Synonyms: BM-212; BM 212; BM212. UNII-U9HSU4GZWL; BM212; 1-[[1,5-bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl]-4-methylpiperazine; 1-{[1,5-Bis(4-chlorophenyl)-2-methylpyrrol-3-yl]methyl}-4-methylpiperazine; U9HSU4GZWL. Grade: 98%. CAS No. 146204-42-4. Molecular formula: C23H25Cl2N3. Mole weight: 414.37. | |
| BM 567 | Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid. It has been reported as a causal factor in the onset of stroke and myocardial infarction. BM 567 is a dual acting antithrombogenic agent, which is acting as an inhibitor of thromboxane A2 (TXA2) synthase and an antagonist of the TP receptor. It also antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. Synonyms: BM567; BM-567. Grade: ≥98%. CAS No. 284464-77-3. Molecular formula: C18H28N4O5S. Mole weight: 412.5. | |
| BM635 | BM635 is an MmpL3 inhibitor with anti-mycobacterial activity. Synonyms: 4-[[1-(4-fluorophenyl)-5-(4-isopropylphenyl)-2-methyl-pyrrol-3-yl]methyl]morpholine. Grade: 99%. CAS No. 1493762-74-5. Molecular formula: C25H29FN2O. Mole weight: 392.52. | |
| BM635 hydrochloride | BM635 hydrochloride, is an MmpL3 inhibitor with great anti-mycobacterial activity. BM635 hydrochloride has an MIC50 of 0.08 μM against M.tuberculosis H37Rv. Molecular formula: C25H30ClFN2O. Mole weight: 428.97. | |
| BM635 mesylate | BM635 mesylate, is an MmpL3 inhibitor with great anti-mycobacterial activity. BM635 mesylate has an MIC50 of 0.6 μM against M. tuberculosis H37Rv. Molecular formula: C26H33FN2O4S. Mole weight: 488.61. | |
| BM 957 | BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM, respectively. Synonyms: BM-957; (R)-5-(4-Chlorophenyl)-1-ethyl-4-(3-(4-(4-((4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl)piperazin-1-yl)phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid; 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-1-ethyl-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-. Grade: ≥95%. CAS No. 1391107-54-2. Molecular formula: C52H56ClF3N6O7S3. Mole weight: 1065.68. | |
| b-Maltosyl azide | b-Maltosyl azide is a useful compound in the biomedical industry commonly used as a reactive probe in click chemistry reactions for the labeling of biomolecules and bioconjugation studies. This azide derivative can facilitate specific and efficient modifications of various drugs, peptides and nucleic acids. Synonyms: 4-O-a-D-Glucopyranosyl-b-D-glucopyranosyl azide. CAS No. 51970-30-0. Molecular formula: C12H21N3O10. Mole weight: 367.3. | |
| b-Methylcrotonyl coenzyme A lithium salt | b-Methylcrotonyl coenzyme A lithium salt, a crucial compound in the biomedicine realm, boasts paramount importance. Its pivotal function lies in the treatment of diverse ailments, notably beta-ketothiolase deficiency—a scarcely encountered metabolic anomaly. Operating as a coenzyme, this product facilitates the degradation of fatty acids, thereby ensuring optimal energy metabolism within the organism. Synonyms: (c5:1)Coenzyme a lithium salt; trans-3-Methyl-2-butenoyl Coenzyme A; lithium [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-4-[[3-[2-(3-methylbut-2-enoylsulfanyl)ethylamino]-3-oxopropyl]amino]-4-oxobutoxy]phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-yl] hydrogen phosphate. Grade: ≥ 95%. CAS No. 108347-83-7. Molecular formula: C26H41LiN7O17P3S. Mole weight: 855.57. | |
| BMH-21 | BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Uses: Enzyme inhibitors. Synonyms: BMH-21; BMH 21; BMH21. Grade: >98%. CAS No. 896705-16-1. Molecular formula: C21H22N4O2. Mole weight: 362.43. | |
| BMH-7 | BMH-7 is a p53 activator with potent antitumor activity. Synonyms: BMH 7; BMH7. CAS No. 379247-14-0. Molecular formula: C20H21N5O. Mole weight: 347.42. | |
| BMI-1026 | BMI-1026 is an exceedingly potent and remarkably selective inhibitor utilized in the biomedical sector, specifically zeroes in on the intricate signalling pathway of interleukin-1 receptor-associated kinase 4 (IRAK-4). Synonyms: BMI 1026; BMI1026; 4-(2-Aminopyrimidin-4-yl)-6-(2-aminopyrimidin-4(3H)-ylidene)cyclohexa-2,4-dien-1-one. Grade: >98%. CAS No. 477726-77-5. Molecular formula: C34H60N3O7PS. Mole weight: 280.29. | |
| BML 111 | BML 111 is a FPR2 (lipoxin A4 receptor) agonist. It inhibits tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. BML 111 also protects against hemorrhagic shock-induced acute lung injury in rats and attenuates renal ischemia/reperfusion injury. Synonyms: BML-111; BML 111; BML111. (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate; methyl (5S,6R)-5,6,7-trihydroxyheptanoate. CAS No. 78606-80-1. Molecular formula: C8H16O5. Mole weight: 192.21. | |
| BML-210 | BML-210 is a Histone deacetylase (HDAC) inhibitor (IC50 = 87 μM), inducingchanges in gene expression profile. Uses: A histone deacetylase (hdac) inhibitor. Synonyms: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433N1-(2-aminophenyl)-N8-phenyloctanediamide; N-(2-aminophenyl)-N'-phenyl-octanediamide. Grade: ≥98%. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| BML-244 | BML-244 is a potent cathespin K inhibitor. Synonyms: BML 244; BML244; (1-formyl-pentyl)-carbamic acid tert-butyl ester; 2-[(tert-Butyloxycarbonyl)amino]hexanal. Grade: 98%. CAS No. 104062-70-6. Molecular formula: C11H21NO3. Mole weight: 215.29. | |
| BML 264 | BML 264 is a TPR channel blocker and phospholipase A2 (PLA2) inhibitor. It blocks the receptor-induced release of arachidonic acid and subsequent signaling cascades in the pancreas and the cardiovascular system. Synonyms: Benzoic acid, 2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-; 2-[[(2E)-1-Oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]benzoic acid; Benzoic acid, 2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]-; Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]-, (E)-; (E)-2-(3-(4-pentylphenyl)acrylamido)benzoic acid; BML264; BML-264. Grade: ≥95%. CAS No. 99196-74-4. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| BML-277 | BML-277 is a selective APT-competitive inhibitor of the DNA damage response signaling enzyme CHK2 ( IC50 =15 nM). Uses: A selective apt-competitive inhibitor. Synonyms: BML-277; BML 277; BML277; Chk2 Inhibitor II; 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide. Grade: ≥98%. CAS No. 516480-79-8. Molecular formula: C20H14ClN3O2. Mole weight: 363.80. | |
| BML-278 | BML-278 is a selective Sirt1 activator (EC150 = 1μM) structurally based on a dihydropyridine scaffold. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. It has much weaker effects on Sirt2 and Sirt3. BML-278 is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. Synonyms: BML 278; BML278. Grade: ≥95%. CAS No. 120533-76-8. Molecular formula: C24H25NO4. Mole weight: 391.5. | |
| BML-284 | BML-284 is potent, selective and cell-permeable Wnt signaling activator. It induces β-catenin and transcription factor (TCF)-dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro. Uses: Bml-284 may be a useful tool in the study of physiological processes that involve the wnt pathway. Synonyms: BML 284; 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine; 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine. Grade: >98%. CAS No. 853220-52-7. Molecular formula: C19H18N4O3. Mole weight: 350.37. | |
| BMN-673 8R,9S | BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Synonyms: Talazoparib (8R,9S); (8R,9S)-BMN-673; BMN673 (8R,9S); BMN 673 (8R,9S). Grade: >98%. CAS No. 1207456-00-5. Molecular formula: C19H14F2N6O. Mole weight: 380.35. | |
| BMP-22 | BMP-22 is an inhibitor of autotaxin with IC50 of 170 nM. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) in vitro in a concentration-dependent manner. MP-22 can decrease the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis. Synonyms: 4-pentadecylbenzylphosphonic acid; BMP22; BMP 22. Grade: ≥95%. CAS No. 1306684-90-1. Molecular formula: C22H39O3P. Mole weight: 382.52. | |
| BMS-002 | BMS-002 is a selective antogonist of lysophosphatidic acid (LPA) receptor-1 developed to treat diabetic nephropathy. In eNOS-/- db/db mouse model, BMS-002 significantly decreased the level of proteinuria. Uses: The potential treatment of diabetic nephropathy. Synonyms: BMS 002; BMS002. | |
| BMS-066 | BMS-066 is an inhibitor of IKKβ/Tyk2 pseudokinase, with IC50s of 9 and 72 nM, respectively. Synonyms: 2-Methoxy-N-((6-(1-methyl-4-(methylamino)-1,5-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide; Acetamide, N-((6-(1,6-dihydro-1-methyl-4-(methylamino)imidazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)-2-pyridinyl)methyl)-2-methoxy-; N-((6-(1,6-Dihydro-1-methyl-4-(methylamino)imidazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)-2-pyridinyl)methyl)-2-methoxyacetamide. Grade: ≥95%. CAS No. 914946-88-6. Molecular formula: C19H21N7O2. Mole weight: 379.42. | |
| BMS-1001 | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with IC50 of 2.25 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Synonyms: BMS 1001; BMS1001. CAS No. 2113650-03-4. Molecular formula: C35H34N2O7. Mole weight: 594.65. | |
| BMS-1001 hydrochloride | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with IC50 of 2.25 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Synonyms: BMS-1001 HCl; (2-((3-Cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride. Grade: 98%. CAS No. 2113650-04-5. Molecular formula: C35H35ClN2O7. Mole weight: 631.12. | |
| BMS-1166 | BMS-1166 is a novel and potent inhibitor of the PD-1/PD-L1 interaction with IC50 of 1.4 nM. Synonyms: BMS1166; BMS 1166. CAS No. 1818314-88-3. Molecular formula: C36H33ClN2O7. Mole weight: 641.11. | |
| BMS-180048 | BMS-180048, also know as Avitriptan Fumarate, has been found to be a5HT-1B/1D-receptor agonist that was once studied as an anti-migraine agent. Synonyms: Avitriptan Fumarate; BMS 180048; BMS-180048; BMS180048; UNII-2G25KE3954; 3-(3-(4--(5-methoxy-4-pyrimidinyl)-1-piperazinyl)propyl)-N-methyl-1H-indole-5-methanesulfonamide fumarate. Grade: 98%. CAS No. 171171-42-9. Molecular formula: C26H34N6O7S. Mole weight: 574.65. | |
| BMS 180448 | BMS 180448 is a prototype mitochondrial ATP-sensitive K+ channel stimulant. The cardioprotective effects of BMS-180448 against I/R heart injury may result from direct activation of mitoK(ATP) channel in cardiomyocytes. In Sep 2003, Phase-II for Myocardial ischaemia in USA was discontinued. Uses: Myocardial ischaemia. Synonyms: BMS 180448; BMS-180448; BMS180448; trans-N-(4-chlorophenyl)-N'-cyano-N''-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)- Guanidine. Grade: 98%. CAS No. 144264-47-1. Molecular formula: C20H18ClN5O2. Mole weight: 395.85. | |
| BMS 180680 | BMS 180680 is antibacterial activity agent of new catechol-containing monobactam. It is a cell wall inhibitor. BMS-180680 is an active compound against many species of the family Enterobacteriaceae, with MICs at which 90% of the isolates were inhibited. In Oct 2002, Phase-II for Respiratory tract infections in USA was discontinued. Uses: Respiratory tract infections. Synonyms: BMS 180680; BMS180680; BMS-180680; SQ 84,100; (2R-(2alpha,3alpha(Z)))-3-((((1-(2-Amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)methyl)-6,7-dihydroxy-2-quinoxalinecarboxylic acid. Grade: 98%. CAS No. 142654-34-0. Molecular formula: C19H17N7O10S2. Mole weight: 567.51. | |
| BMS 181101 | BMS 181101, an indole derivative, has been found to be a 5-HT receptor agonist that could be probably effective against depression and also restrain serotonin reuptake at some extent. It has already been discontinued by Bristol-Myers Squibb. Synonyms: BMS 181101; BMS181101; BMS-181101; AC1L42ZR; SCHEMBL4356376; DTXSID40163380; 5-fluoro-3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indole Dihydrochloride. Grade: 98%. CAS No. 146479-45-0. Molecular formula: C20H26Cl2FN5O. Mole weight: 442.36. | |
| BMS 181168 | This active molecular is an potential cognitive enhancer originated by Bristol-Myers Squibb. Mechanism of Action is not identified. Bmy 21502 is also a nootropic agent and it can protect rodents from ECS-induced amnesia in a step-down passive avoidance task. But clinical study for treatment of Alzheimer's disease was discontinued. Uses: Alzheimer's disease. Synonyms: Bmy 21502; Bmy21502; Bmy-21502; Bms-181168; Bms 181168; Bms181168. 1-((1-(2-(trifluoromethyl)pyrimidin-4-yl)piperidin-4-yl)methyl)pyrrolidin-2-one. Grade: 98%. CAS No. 123259-91-6. Molecular formula: C15H19F3N4O. Mole weight: 328.34. | |
| BMS 182264 | BMS 182264 is a bio-active chemical, but few detailed information has been published yet. Synonyms: BMS 182264; BMS-182264; BMS182264; CHEMBL19169; N-Cyano-N'-(4-cyanophenyl)-N''-1,2,2-trimethylpropylguanidine. Grade: 98%. CAS No. 127749-54-6. Molecular formula: C15H19N5. Mole weight: 269.35. | |
| BMS 182874 | BMS 182874 is an endothelin receptor antagonist used as an antihypertensive agent. Uses: Antihypertensive agents. Synonyms: 5-Ddins; BMS 182874; BMS-182874; BMS182874; CHEMBL267458; 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide. CAS No. 153042-42-3. Molecular formula: C17H19N3O3S. Mole weight: 345.417. | |
| BMS 182874 Hydrochloride | This active molecular is a selective non-peptide Endothelin ETA receptor antagonist. It displays more than 1000-fold selectivity over ETB receptors (Ki of 48 nM for ETA receptors and >50 μM for ETB). BMS 182874 displays ET-1 inhibitory efficacy in vivo and vitro and it also inhibits ET-1-induced longitudinal muscle contraction in vitro. In 2006, BMS 182874 for coronary disorders and hypertension were discontinued in USA. Uses: Coronary disorders and hypertension. Synonyms: BMS 182874; BMS-182874; BMS182874; BMS 182874 HCl; BMS 182874 hydrochloride; 5-(dimethylamino)-N-(3,4-dimethylisoxazol-5-yl)naphthalene-1-sulfonamide hydrochloride. Grade: 98%. CAS No. 1215703-04-0. Molecular formula: C17H20ClN3O3S. Mole weight: 381.88. | |
| BMS 183920 | BMS 183920, a quinoline derivative, has been found to be an angiotensin II receptor antagonist that could have potential usage in antihypertensive study. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: BMS 183920; BMS-183920; BMS183920; CHEMBL305365; 2-Cyclopropyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)oxy)-4-quinolinecarboxylic acid; 4-Quinolinecarboxylicacid, 2-cyclopropyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]oxy]-. Grade: 98%. CAS No. 153072-33-4. Molecular formula: C26H19N5O3. Mole weight: 449.47. | |
| BMS-186318 | BMS-186318 has been found to be a HIV protease inhibitor that was once studied against HIV by Bristol-Myers Squibb. Synonyms: BMS 186318; BMS-186318; BMS186318; 12-Oxa-2,6,10-triazatetradecanoic acid, 4,8-dihydroxy-13,13-dimethyl-3-((4-(2-(4-morpholinyl)-2-oxoethoxy)phenyl)methyl)-11-oxo-9-(phenylmethyl)-, 1,1-dimethylethyl ester, (3S,4R,8R,9S)-; BMS-186318 analog 19; 12-Oxa-2,6,10-triazat. Grade: 98%. CAS No. 161302-40-5. Molecular formula: C36H54N4O9. Mole weight: 686.85. | |
| BMS-186511 | BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. Synonyms: BMS186511; BMS 186511; ((5S,8S,11S)-8,11-diisopropyl-5-(methoxycarbonyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-15-yl)((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)phosphinic acid. Grade: >98%. CAS No. 167467-53-0. Molecular formula: C26H27N5O5. Mole weight: 685.90. | |
| BMS-187071 | BMS-187071 has been found to be a HIV protease inhibitor that was once studied against HIV by Bristol-Myers Squibb. Synonyms: BMS 187071; BMS187071; BMS187071; (3-((3-((2,3,3-Trimethyl-2(S)-2-hydroxy-1-oxobutyl)amino)-2-hydroxy-4-phenylbutyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamic acid, 1,1-dimethylethyl ester; [3-[[3-[(2,3,3-Trimethyl-2(S)-2-hydroxy-1-oxobutyl)amino]-2-hydroxy-4. Grade: 98%. CAS No. 161302-39-2. Molecular formula: C32H49N3O6. Mole weight: 571.75. | |
| BMS-187308 | BMS-187308, a sulfonamide derivative, has been found to be an endothelin-A (ETA) antagonist that was once studied about its activity against pressor effect in rats. Synonyms: BMS-187308; BMS 187308; BMS187308; UNII-7K0YU35900; CHEMBL106684; 7K0YU35900; SCHEMBL6767698; BDBM50068674; 2-[2-amino-4-(2-methylpropyl)phenyl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide. Grade: 98%. CAS No. 153624-15-8. Molecular formula: C21H25N3O3S. Mole weight: 399.51. | |
| BMS-188494 | BMS-188494 is the prodrug of BMS-187745, a squalene synthase inhibitor used as an anticholesterol drug. Synonyms: 1-[bis(2,2-dimethylpropanoyloxymethoxy)phosphoryl]-4-(3-phenoxyphenyl)butane-1-sulfonic acid; BMS-188494; BMS 188494; BMS188494; UNII-F4W2579G7P. Grade: >98%. CAS No. 191866-32-7. Molecular formula: C28H39O11PS. Mole weight: 614.645. | |
| BMS 191011 | BMS 191011 is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It is neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke). Synonyms: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-one; BMS-191011; BMS 191011; BMS191011; UNII-LW7MXS978N; Bms-a. Grade: >99 %. CAS No. 202821-81-6. Molecular formula: C16H10ClF3N3O3. Mole weight: 370.71. | |
| BMS-191095 | BMS-191095 is an activators that has selective effects on mitochondrial ATP-sensitive potassium (mitoKATP) channels. in vitro: induces mitochondrial-depolarization and vasodilation. Synonyms: (3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrileBMS-191095; BMS 191095; BMS191095CHEMBL11594SCHEMBL8896325ZINC3821976BDBM50409914. CAS No. 166095-21-2. Molecular formula: C22H21ClN4O2. Mole weight: 408.88. | |
| BMS-192364 | BMS-192364 is a prominent and discriminating inhibitor, finding profound application in the research of cancer. Specifically designed for efficacious cancer research, this remarkable compound effectively obstructs kinases that play a crucial role in the propagation and sustenance of malignant cells. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-192364; BMS 192364; BMS192364; UNII-1NC8D8P7QF. Grade: >98%. CAS No. 202822-21-7. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS-193884 | BMS-193884, an oxazol derivative, has been found to be an endothelin A receptor antagonist and was once studied in the treatmen of heart failure. Uses: Endothelin receptor antagonists. Synonyms: BMS-193884; BMS 193884; BMS193884; 7ON53PV45J; SCHEMBL4204130; BDBM50091105; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide. Grade: 98%. CAS No. 176960-47-7. Molecular formula: C20H17N3O4S. Mole weight: 395.43. | |
| BMS-193885 | BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50=5.9nM, Ki=3.3 nM. BMS-193885 displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Synonyms: dimethyl 4-[3-[3-[4-(3-methoxyphenyl)piperidin-1-yl]propylcarbamoylamino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; BMS 193885; 679839-66-8BMS-193885; BMS193885; BMS 193885. Grade: >98%. CAS No. 186185-03-5. Molecular formula: C33H42N4O6. Mole weight: 590.71. | |
| BMS-193885 salt | BMS-193885 is a potent and selective neuropeptide Y1 receptor antagonist with IC50=5.9nM, Ki=3.3 nM. BMS-193885 displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Synonyms: BMS 193885; BMS193885; 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-dimethyl ester-3,5-pyridinedicarboxylic acid. Grade: >98%. CAS No. 679839-66-8. Molecular formula: C36H48N4O9. Mole weight: 680.79. | |
| BMS-194449 | BMS-194449 was found to be a β-adrenergic receptor agonist that was once studied in antihyperglycaemics as well as obesity therapy. Synonyms: BMS-194449; BMS 194449; BMS194449; UNII-93ZDV2P17I; CHEMBL320915; 93ZDV2P17I; SCHEMBL7042103; BDBM50106794; (R)-N-(5-(2-((bis(4-(difluoromethoxy)phenyl)methyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide. Grade: 98%. CAS No. 170686-12-1. Molecular formula: C24H24F4N2O6S. Mole weight: 544.52. | |
| BMS-195270 | BMS-195270 is a robust and discriminating small molecule inhibitor, finding paramount application in the biomedical sector. Its remarkable efficacy against fibroblast growth factor receptor 4 (FGFR4) imparts exceptional potency, rendering it a formidable intervention modality for malignancies driven by FGFR4. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-195270; BMS 195270; BMS195270; UNII-20UM0T170J; CHEMBL13637; SCHEMBL5754043; 20UM0T170J. Grade: >98%. CAS No. 202822-23-9. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS 195614 | BMS 195614 is a neutral RARα selective antagonist (Ki = 2.5 nM) and exhibits no significant effect on nuclear receptor corepressor (NCoR) binding. BMS 195614 moderately decreases SMRT binding to RAR and agonist-induced coactivator (CoA) recruitment. Synonyms: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid; 4-({[5,5-Dimethyl-8-(3-quinolinyl)-5,6-dihydro-2-naphthalenyl]carbonyl}amino)benzoic acid; Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-; BMS 614. Grade: ≥98% by HPLC. CAS No. 253310-42-8. Molecular formula: C29H24N2O3. Mole weight: 448.51. | |
| BMS-196085 | BMS-196085, a sulfanilamide derivative, has been found to be a β-adrenergic receptor agonist that was once studied in obesity as well as yype 2 diabetes mellitus. Synonyms: BMS-196085; BMS 196085; BMS196085; CHEMBL322862; FM0D5L3W03; SCHEMBL7042488; BDBM50106829; UNII-FM0D5L3W03; N-[5-[(1R)-2-[[(1R)-1-[4-(difluoromethoxy)phenyl]-2-phenylethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide. Grade: 98%. CAS No. 170686-10-9. Molecular formula: C24H26F2N2O5S. Mole weight: 492.54. | |
| BMS-199264 hydrochloride | BMS-199264 hydrochloride is a novel potent inhibitor of the ATP hydrolase activity of mitochondrial F1F0 ATP synthase. Synonyms: BMS-199264 HCl. CAS No. 186180-83-6. Molecular formula: C26H32Cl2N4O4S. Mole weight: 567.53. | |
| BMS202 hydrochloride | The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM. Synonyms: PD-1/PD-L1 inhibitor 2 hydrochloride. Molecular formula: C25H30ClN3O3. Mole weight: 455.97. | |
| BMS-210285 | BMS-210285 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-210285; BMS210285; BMS 210285; UNII-WS7S13Q9RH; CHEMBL60116; WS7S13Q9RH; SCHEMBL13550990; BDBM50073046. N-[5-[(1R)-2-[[(1R)-2-(3-chlorophenyl)-1-[4-(difluoromethoxy)phenyl]ethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide. Grade: ≥98%. CAS No. 344607-69-8. Molecular formula: C24H25ClF2N2O5S. Mole weight: 526.98. | |
| BMS-212 | BMS-212 is a potent and selective stimulator of glucokinase (GK) (EC50 = 35 nM) that is promisingly used as an antidiabetic. BMS-212 has a preference for GK in liver over GK in pancreas, of which the activation may lead to non-glucose-dependent insulin secretion. Half-life of BMS-212 is 4.2h, and oral bioavailability is 15%. Uses: Potential antidiabetic. Synonyms: BMS212; BMS 212. CAS No. 2173153-38-1. Molecular formula: C25H30N3O9PS2. Mole weight: 611.62. | |
| BMS-212122 | BMS-212122 is a benzimidazole-based analogue of the potent MTP inhibitor BMS-201038. Synonyms: 9-[4-[2,5-dimethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide; BMS-212122; BMS212122; BMS 212122; UNII-0Z473OO6GB. Grade: >98%. CAS No. 194213-64-4. Molecular formula: C43H36F6N4O2. Mole weight: 754.76. | |
| BMS 214428 | BMS 214428 has antineoplastic effect. Synonyms: dimethyl 4-[3-[[N-cyano-N'-[3-(4-phenylpiperidin-1-yl)propyl]carbamimidoyl]amino]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; UNII-6774Z74TWN; 6774Z74TWN; BMS 214428; BMS-214428; BMS214428. Grade: >98%. CAS No. 216508-01-9. Molecular formula: C33H40N6O4. Mole weight: 584.71. | |
| BMS-214662 | BMS-214662 is a Farnesyltransferase inhibitor and a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. Synonyms: BMS 214662; BMS214662; ARQ-171; ARQ 171; ARQ171; (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile. Grade: 98%. CAS No. 195987-41-8. Molecular formula: C25H23N5O2S2. Mole weight: 489.61. | |
| BMS-214662 hydrochloride | BMS-214662, a nonsedating benzodiazepine derivative, inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction. Treatment with BMS-214662 may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. BMS-214662 may be a useful drug for treating B-CLL and, in particular, an alternative for the therapy of purine analog-resistant or relapsed B-CLL. Synonyms: (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile; 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine; ARQ171; ARQ 171; ARQ-171; BMS214662; BMS214662; BMS-214662. Grade: >98%. CAS No. 195981-08-9. Molecular formula: C25H24ClN5O2S2. Mole weight: 526.1. | |
| BMS-214662 mesylate | BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ. Uses: A potent and selective inhibitor of farnesyltransferase. Synonyms: BMS-214662 mesylate; BMS 214662 mesylate; BMS214662 mesylate; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine mesylate. Grade: ≥98%. CAS No. 474010-58-7. Molecular formula: C25H25N5O6S3. Mole weight: 585.72. | |
| BMS-229724 | BMS-229724 is a selective tight-binding inhibitor of cytosolic phospholipase A2 (cPLA2) in that it did not inhibit secreted phospholipase A2 in vitro, nor phospholipase C and phospholipase D in cells. BMS-22972 acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. Synonyms: 4-[4-[2-[2-[bis(4-chlorophenyl)methoxy]ethylsulfonyl]ethoxy]phenyl]-1,1,1-trifluorobutan-2-one; 4-(4-(2-(2-(bis(4-chlorophenyl)methoxy)ethylsulfonyl)ethoxy)phenyl)-1,1,1-trifluoro-2-butanone; BMS-229724; BMS 229724; BMS229724; 42AD6D8ECA; SCHEMBL3304414; LS-46643; UNII-42AD6D8ECA. Grade: >98%. CAS No. 221914-85-8. Molecular formula: C27H25Cl2F3O5S. Mole weight: 589.45. | |
| BMS-243117 | BMS-243117 is a potent and selective Lck inhibitor with good cellular activity against T-cell proliferation. BMS-24311 has potential to treat diseases such as rheumatoid arthritis and asthma. Synonyms: BMS-243117; BMS 243117; BMS243117; UNII-MBE6KWV0QI; CHEMBL67237; MBE6KWV0QI; SCHEMBL6058200. 2-(tert-butylcarbamoylamino)-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide; BMS-243117; UNII-MBE6KWV0QI. Grade: >98%. CAS No. 225521-80-2. Molecular formula: C20H21ClN4O2S. Mole weight: 416.92. | |
| BMS-247243 | BMS-247243 is a novel β-Lactamase inhibitor which is a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Uses: Beta-lactamase-inhibitor. Synonyms: BMS-247243; BMS 247243; BMS247243; UNII-KG8365V22L. (6R,7R)-7-[[2-[4-[(E)-3-(carboxylatomethylamino)-3-oxoprop-1-enyl]-2,5-dichlorophenyl]sulfanylacetyl]amino]-3-[[2,6-dimethyl-1-[3-(4-methylmorpholin-4-ium-4-yl)propyl]pyridin-1-ium-4-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Grade: ≥98%. CAS No. 307316-55-8. Molecular formula: C36H41Cl2N5O8S3. Mole weight: 838.83. | |
| BMS-248360 | BMS-248360 is a first orally active generation dual action receptor antagonist. BMS-248360 antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50=8.5, ETA IC50=8.9 nM). Synonyms: 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-[(3,3-dimethyl-2-oxopyrrolidin-1-yl)methyl]phenyl]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide; BMS-248360; BMS 248360; BMS248360; UNII-EEP77N970Y; CHEMBL11706; EEP77N970Y; SCHEMBL4764273; BDBM50117910. Grade: >98%. CAS No. 254737-87-6. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
| BMS 262084 | BMS 262084 is a potent and selective azetidinone-based beta-lactam tryptase inhibitor. Synonyms: (2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylic acid; BMS-262084; BMS 262084; BMS262084; CHEMBL71037; UNII-I0IR71971G; I0IR71971G; BDBM50120368; DNC004491. Grade: >98%. CAS No. 253174-92-4. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| BMS-265246 | BMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM. It is 25-fold more selective for CDK1/2 than CDK4. Synonyms: BMS265246; BMS-265246; BMS 265246. Grade: >98%. CAS No. 582315-72-8. Molecular formula: C18H17F2N3O2. Mole weight: 345.34. | |
| BMS 270394 | BMS 270394 is a nuclear retinoic acid receptor (RAR-γ) agonist. Synonyms: BMS270394; BMS-270394 ; BMS 270394; BMS 189961; BMS189961; BMS-189961; (R)-3-fluoro-4-(2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamido)benzoic acid; 3-fluoro-4-[[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetyl]amino]benzoic acid. Grade: 99%. CAS No. 262433-54-5. Molecular formula: C23H26FNO4. Mole weight: 399.46. | |
| BMS-275183 | BMS-275183 is an oral C-4 methyl carbonate analogue of paclitaxel that has the same mechanism of action, stabilization of tubulin polymerization. BMS-275183 given p.o. was active in a human, hormone-dependent, prostate tumor model, CWR-22, and just as effective as anti-androgen chemotherapy. BMS-275185 is lack of evidence of clinical benefit with the occurrence of two fatal events of neutropenic sepsis. Synonyms: BMS 275183; BMS275183. CAS No. 355113-98-3. Molecular formula: C43H59NO16. Mole weight: 845.94. | |
| BMS-279700 | BMS-279700, belonging to a family of novel anilino 5-azaimidazoquinoxaline analogues, is an orally active lead candidate that blocks the production of proinflammatory cytokines (IL-2 and TNFalpha) in vivo. Synonyms: (S)-N-(2-chloro-6-methylphenyl)-2-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine; BMS279700; BMS 279700; BMS-279700. Grade: >98%. CAS No. 240814-54-4. Molecular formula: C21H22ClN7. Mole weight: 407.899. | |
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