BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BMS-284640 | BMS-284640 is a Na(+)/H(+) exchanger (NHE) inhibitor developed for the treatment of cardiovascular therapies. Synonyms: BMS 284640; BMS284640; N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dimethyl-cyclopropanecarbonyl]-guanidine. Grade: >98%. CAS No. 230640-88-7. Molecular formula: C15H19N3O2. Mole weight: 273.33. |  |
| BMS 299897 | BMS 299897, under the IUPAC name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid, synthesized by the radiosynthesis group at Bristol-Myers Squibb, is a β-secretase inhibitor that has the potential for treatment of Alzheimer's diseases (IC50 = 12 nM; gamma-secretase express: EC50 = 7 nM (CHO cells)). BMS 299897 blocks the formation of Aβ40 (IC50 = 7.9 nM) and Aβ42 (IC50 = 7.9 nM) in the brain, and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Synonyms: 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid; 4-(2-((1R)-1-(((4-chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid; BMS299897; BMS 299897; BMS-299897; 290315-45-6; 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid; C24H21ClF3NO4S; CHEMBL247471; SCHEMBL6394108; DTXSID50460039; 3496AH; ZINC28883606; AKOS024457319; CCG-222540; CS-1339; NCGC00346875-01; HY-50883; KB-75603; DB-017854; W-5550; BRD-K02950022-001-01-1; 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid; BMS 299897|2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid. CAS No. 290315-45-6. Molecular formula: C24H21ClF3NO4S. Mole weight: 511.94. | |
| BMS-3 | BMS-3, a LIMK1 inhibitor, could be probably influence the migration and cycle progression of cells so that has patential value in studying its effect against cancer. Synonyms: N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)cyclopropanecarboxamide; BMS3; BMS 3; Cyclopropanecarboxamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-; N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}cyclopropanecarboxamide. Grade: 95%. CAS No. 1338247-30-5. Molecular formula: C17H12Cl2F2N4OS. Mole weight: 429.27. | |
| BMS303141 | BMS 303141 is a cell-permeable, 2-hydroxy-N-arylbenzenesulfonamide that inhibits ACL with an IC50 value of 0.13 μM. BMS 303141 has been reported to reduce weight gain and lower plasma cholesterol, triglycerides, and glucose in a mouse model of hyperlipidemia. Synonyms: BMS303141; BMS-303141; BMS 303141. CAS No. 943962-47-8. Molecular formula: C19H15Cl2NO4S. Mole weight: 424.30. | |
| BMS 309403 | BMS 309403 is a potent, selective and cell-permeable inhibitor of adipocyte fatty acid binding protein (FABP4) with a Ki of less than 2 nM, which exhibits Ki values of 250 nM for FABP3 and 350 nM for FABP5. BMS 309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS 309403 is a biphenyl azole inhibitor against fatty acid binding protein 4 (FABP4) and regarded as a lead compound for effective treatment of obesity related cardio-metabolic diseases. Synonyms: BMS-309403; BMS309403; Adipocyte FABP Inhibitor; A-FABP Inhibitor; ALBP Inhibitor; aP2 Inhibitor; FABP4 Inhibitor; Fatty Acid Binding Protein 4 Inhibitor. Grade: ≥98%. CAS No. 300657-03-8. Molecular formula: C31H26N2O3. Mole weight: 474.55. | |
| BMS-317180 | BMS-317180 is a potent, and orally effective growth hormone secretagogue (GHS) that shows an excellent safety profile in preclinical studies. Synonyms: BMS317180; BMS 317180; (S)-2-(5-(1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl)-1H-tetrazol-1-yl)ethyl (4-hydroxybutyl)carbamate. Grade: >98%. CAS No. 295337-71-2. Molecular formula: C26H30N5O2P. Mole weight: 463.54. | |
| BMS-337197 | BMS-337197 is a a potent inhibitor of IMPDH with potential anticancer activity. Synonyms: BMS 337197; BMS337197; N-(2-(2-((3-methoxy-4-(oxazol-5-yl)phenyl)amino)oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide. Grade: >98%. CAS No. 267645-83-0. Molecular formula: C24H34N5OP. Mole weight: 489.53. | |
| BMS-344577 | BMS-344577 is aroylguanidine-based lactam derivative, which is a potent FXa inhibitor (FXa IC(50)=4 nM, EC(2xPT)=7 microM). Uses: Aroylguanidine-based factor xa inhibitor. Synonyms: BMS-344577; BMS344577; BMS 344577; UNII-U259PQB19A; CHEMBL570867; U259PQB19A; BDBM35316; BDBM50328724; N5-[[[(3S)-Hexahydro-2-oxo-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-azepin-3-yl]imino][(2-methyl-5-benzofuranyl)amino]methyl]-N2,N2-dimethyl-2,5-pyridinedicarboxamide; (S,E)-N2,N2-dimethyl-N5-(N'-(2-methylbenzofuran-5-yl)-N-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)carbamimidoyl)pyridine-2,5-dicarboxamide. Grade: ≥95%. CAS No. 288079-93-6. Molecular formula: C31H37N7O5. Mole weight: 587.67. | |
| BMS-345541 | BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. Synonyms: BMS-345541 free base; BMS345541; UNII-26SU0NEF5F; BMS 345541; BMS-345541. Grade: >98%. CAS No. 445430-58-0. Molecular formula: C14H17N5. Mole weight: 255.32. | |
| BMS 345541 trifluoroacetate salt | BMS 345541 is a cell-permeable inhibitor of the IκB kinases IKKα with IC50s of 4 uM and IKKβ with IC50s of 0.3 μM, which binds at allosteric site of the enzyme and displays ~10-fold greater selectivity at IKK-2 over IKK-1. It exhibits no effect against a panel of 15 other kinases. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling. Synonyms: IKK Inhibitor III. Grade: ≥98%. CAS No. 547757-23-3. Molecular formula: C14H17N5ยท2CF3COOH. Mole weight: 483.4. | |
| BMS-347070 | BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer. Synonyms: (3Z)-3-[(4-bromophenyl)-(4-methylsulfonylphenyl)methylidene]oxolan-2-one; BMS-347070; BMS 347070; BMS347070; UNII-0CKM4H090C; 0CKM4H090C; SCHEMBL6882900; SCHEMBL6882905. Grade: >98%. CAS No. 197438-73-6. Molecular formula: C18H15BrO4S. Mole weight: 407.28. | |
| BMS-351 | BMS-351 is a selective and nonsteroidal CYP17A1 lyase inhibitor with good selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 has become a preclinical candidate to treat Castration-resistant prostate cancer (CRPC) and is likely to minimize the side effects of current therapies because of its exceptional selectivity. Uses: Castration-resistant prostate cancer. Synonyms: BMS-351; BMS 351; BMS351; 4-(4-methylpyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazole. Grade: 98%. CAS No. 1370001-71-0. Molecular formula: C15H12F3N3. Mole weight: 291.28. | |
| BMS-354326 | BMS-354326 is a tryptase inhibitor with IC50 value of 1.8 nM. It has excellent selectivity against trypsin and most other related serine proteases. Synonyms: BMS-354326; BMS 354326; BMS354326; CHEMBL306448; BDBM50144532.(2S,3R)-4-oxo-1-((4-(1-oxo-6-phenylhexyl)-1-piperazinyl)carbonyl)-3-(2-(3-piperidinyl)ethyl)- 2-Azetidinecarboxylic acid. Grade: 98%. CAS No. 708258-16-6. Molecular formula: C28H40N4O5. Mole weight: 512.65. | |
| BMS358233 | BMS358233 is a potent Lck inhibitor. It has excellent cellular activities against T-cell proliferation. Uses: Bms358233 has excellent cellular activities against t-cell proliferation. Synonyms: BMS-358233; BMS 358233; 6-Benzothiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-methyl-2-((((2R)-tetrahydro-2-furanyl)methyl)amino)-4-pyrimidinyl)amino)-. Grade: 98%. CAS No. 601519-75-9. Molecular formula: C25H25ClN6O2S. Mole weight: 509.02. | |
| BMS-36313 | BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin. Uses: Tryptase inhibitor. Synonyms: BMS-363131; BMS 363131; BMS363131. (2S,3R)-3-[[(3R)-1-carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acid. Grade: ≥98%. CAS No. 384829-65-6. Molecular formula: C28H40N6O5. Mole weight: 540.66. | |
| BMS-378806 | BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. Synonyms: BMS-378806; BMS 378806; BMS378806; BMS-806; BMS806; Bms 806. Grade: >98%. CAS No. 357263-13-9. Molecular formula: C22H22N4O4. Mole weight: 406.43. | |
| BMS-394136 | BMS-394136 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-394136; BMS 394136; BMS394136; UNII-M694U7167K. [(7R)-7-(3,4-dichlorophenyl)-5-methyl-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanone. Grade: ≥98%. CAS No. 343246-73-1. Molecular formula: C24H21Cl2FN4O. Mole weight: 471.35. | |
| BMS-419437 | BMS-419437 is a synthetic organic bio-active chemical. Uses: A synthetic organic bio-active chemical. Synonyms: BMS-419437; BMS419437; BMS 419437; UNII-09RR39UU4V; CHEBI:34550; AC1NQZWA; BMS-387032 analog 2. N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenyl]acetamide. Grade: ≥98%. CAS No. 333389-24-5. Molecular formula: C23H30N4O4S2. Mole weight: 490.64. | |
| BMS 433771 | BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM. Uses: Viral fusion protein inhibitor. Synonyms: BMS 433771; BMS433771; BMS-433771; BMS-433771 HCl hydrate; BMS-433771 HCl; BMS-433771 hydrochloride. 1-cyclopropyl-1,3-dihydro-3-((1-(3-hydroxypropyl)-1H-benzimidazol-2-yl)methyl)-2H-Imidazo(4,5-c)pyridin-2-one. Grade: ≥98%. CAS No. 380603-10-1. Molecular formula: C20H21N5O2. Mole weight: 363.41. | |
| BMS-433796 | BMS-433796 is a γ-secretase inhibitor. Chronic dosing of BMS-433796 in Tg2576 mice suggested a narrow therapeutic window and Notch-mediated toxicity at higher doses. Uses: Gamma secretase inhibitors and modulators. Synonyms: BMS433796; BMS-433796; BMS 433796. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(5S)-3-methyl-4-oxo-5H-2,3-benzodiazepin-5-yl]propanamide; BMS-433796; UNII-R1E8M783K2; 935525-13-6; CHEMBL247361; R1E8M783K2; ZINC28899741; (alphaS)-N-[(1S)-2-[[(5S)-4,5-Dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide; (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide; Benzeneacetamide, N-((1S)-2-(((5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl)amino)-1-methyl-2-oxoethyl)-3,5-difluoro-alpha-hydroxy-, (alphaS)-. CAS No. 935525-13-6. Molecular formula: C21H20F2N4O4. Mole weight: 430.15. | |
| BMS 453 | BMS 453 is a synthetic retinoid that acts as an RARβ agonist in vivo, and also an RARα and RARγ antagonist in vitro. It inhibits the proliferation of breast cells by inducing active transforming growth factor β (TGFβ) and causes G1 arrest. Synonyms: BMS453; BMS 453; BMS-453; BMS 189453; BMS-189453; BMS189453. 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid. Grade: ≥98% by HPLC. CAS No. 166977-43-1. Molecular formula: C27H24O2. Mole weight: 380.48. | |
| BMS 470539 dihydrochloride | BMS 470539 dihydrochloride is a potent and selective melanocortin MC1 receptor agonist (IC50 = 120 nM) with anti-inflammatory activity. It also inhibits leukocyte trafficking. Synonyms: BMS 470539 dihydrochloride; BMS470539 dihydrochloride; BMS-470539 dihydrochloride; 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride. Grade: ≥98% by HPLC. Molecular formula: C32H41N5O4.2HCl. Mole weight: 632.62. | |
| BMS-470539 dihydrochloride | BMS 470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC1) agonist with an IC50 of 120 nM, an EC50 of 28 nM. It exhibits anti-inflammatory properties. Synonyms: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride; BMS 470539 dihydrochloride. CAS No. 2341796-82-3. Molecular formula: C32H43Cl2N5O4. Mole weight: 632.63. | |
| BMS480404 | BMS480404 is a potent small molecule inhibitor. It bounds to human keratinocyte fatty acid-binding protein. Synonyms: BMS-480404; BMS 480404; (S)-2-(2,3-bis(2-chlorobenzyloxy)phenyl)-2-hydroxyacetic acid. Grade: 98%. CAS No. 533889-36-0. Molecular formula: C22H18Cl2O5. Mole weight: 433.28. | |
| BMS 488043 | BMS-488043 is a small-molecule HIV fusion inhibitor. Uses: Hiv fusion inhibitor. Synonyms: BMS-488043; 452296-83-2; BMS 043; BMS 488043; 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione; BMS043; BMS-043; CHEMBL238103; MKS21EJ435; 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-; 1-Benzoyl-4-(2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-2-oxoacetyl]piperazine; 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)ethane-1,2-dione; UNII-MKS21EJ435; DBPMWRYLTBNCCE-UHFFFAOYSA-N; 1-BENZOYL-4-(2-(4,7-DIMETHOXY-1H-PYRROLO(2,3-C)PYRIDIN-3-YL)-2-OXOACETYL)PIPERAZINE; BMS488043; SCHEMBL2688411; DTXSID501006367; GLXC-15766; BDBM50228465; AKOS040750864; DB05532; HY-14135; TS-08685; CS-0003220; NS00071850; Q27284087; n-(benzoyl)-n'-[(4,7-dimethoxy-6-azaindol-3-yl)-oxoacetyl]-piperazine; n-(benzoyl)-n'-[(4,7-dimethoxy-6-azaindol-3-yl)-oxoacetyl]piperazine; 1-(4-benzoyl-1-piperazinyl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-1,2-ethanedione; 1-[4-(benzoyl)piperazin-1-yl]-2-(4,7-dimethoxy-1h-pyrrolo[5,4-c]pyridin-3-yl)ethane-1,2-dione; 857500-24-4; Piperazine, 1-benzoyl-4-[2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-. Grade: ≥98%. CAS No. 452296-83-2. Molecular formula: C22H15NO7. Mole weight: 405.4. | |
| BMS 493 | BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Synonyms: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic Acid; BMS-493; BMS493; (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid; Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-. Grade: 97%. CAS No. 215030-90-3. Molecular formula: C29H24O2. Mole weight: 404.50. | |
| BMS-5 | BMS-5, a LIMK inhibitor, has been found to restrain the cofilin phosphorylation in MDA-MB-231 breast cancer cells. Synonyms: LIMKi 3; N-(5-(1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide; N-{5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}-2-methylpropanamide; BMS 5; BMS5. Grade: 98%. CAS No. 1338247-35-0. Molecular formula: C17H14Cl2F2N4OS. Mole weight: 431.29. | |
| BMS-502 | BMS-502 is an inhibitor of diacylglycerol kinase α (DGK-α), DGK-ζ, and DGK-Ι with IC50s of 0.0046, 0.0021, and 0.0026 μM, respectively. BMS-502 induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. Synonyms: BMS 502; BMS502. CAS No. 2407854-18-4. Molecular formula: C27H22F2N6O3. Mole weight: 516.50. | |
| BMS-505130 | BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters is 2.1 mM. Synonyms: BMS-505130; BMS 505130; BMS505130; UNII-E892TW82D9; E892TW82D9; 1H-Indole-5-carbonitrile, 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-, (2Z)-2-butenedioate (1:1). Grade: 98%. CAS No. 859230-84-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
| BMS-505130 Free base | BMS-505130 is a potent and selective serotonin transport inhibitor with K(I) of 0.18 nM. Uses: A potent and selective serotonin transport inhibitor. Synonyms: BMS-505130; BMS 505130; BMS505130; 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-1H-Indole-5-carbonitrile. Grade: ≥98%. CAS No. 468715-83-5. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| BMS-509744 | BMS-509744 is a selective Itk inhibitor. It is useful for treatment of inflammatory and autoimmune diseases. Synonyms: BMS-509744; BMS 509744; BMS509744; CHEMBL209148. Grade: >98%. CAS No. 439575-02-7. Molecular formula: C32H41N5O4S2. Mole weight: 623.83. | |
| BMS-520 | This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthritis as well as in a mouse EAE (experimental autoimmune encephalomyelitis) model of multiple sclerosis. Agonism of S1P1 has been known to play an important role in lymphocyte trafficking from the thymus and secondary lymphoid organs, resulting in immunosuppression. Uses: Haematological malignancies; solid tumours. Synonyms: BMS-520; BMS 520; BMS520. 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid. Grade: 98%. CAS No. 1236188-38-7. Molecular formula: C23H17F3N4O4. Mole weight: 470.41. | |
| BMS-536924 | BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma. Synonyms: BMS536924; BMS 536924; Insulin-like Growth Factor-1 Receptor Inhibitor; (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one. Grade: 98%. CAS No. 468740-43-4. Molecular formula: C25H26ClN5O3. Mole weight: 479.96. | |
| BMS538158 | BMS538158 is a bio-active chemical compound developed by Bristol-Myers Squibb. Synonyms: BMS-538158; BMS 538158; Acetamide, 2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)-N-((4-fluorophenyl)methyl)-N-methoxy-. Grade: 98%. CAS No. 543730-36-5. Molecular formula: C15H16FNO5. Mole weight: 309.29. | |
| BMS-538203 | BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent. Synonyms: BMS-538203; BMS 538203; BMS538203. Grade: >98%. CAS No. 543730-41-2. Molecular formula: C12H12FNO5. Mole weight: 269.23. | |
| BMS-554417 | BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, with the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). Uses: A novel inhibitor of igf-ir. Synonyms: BMS-554417; BMS 554417; BMS554417; 3-[4-[(2Z)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperazin-1-yl]propanenitrile. Grade: ≥98%. CAS No. 468741-42-6. Molecular formula: C28H30ClN7O2. Mole weight: 532.04. | |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?; BMS-561392; DPC-333; (2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grade: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BMS-564929 | BMS-564929 is a novel androgen receptor (AR) modulator (Ki= 2.11 nM) which has been advanced to clinical trials for the treatment of age-related functional decline. Uses: Androgen receptor (ar) modulator. Synonyms: BMS-564929; BMS 564929; BMS564929. 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-2-chloro-3-methylbenzonitrile. Grade: ≥98%. CAS No. 627530-84-1. Molecular formula: C14H12ClN3O3. Mole weight: 305.71. | |
| BMS-566419 | Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Synonyms: BMS 566419; BMS566419; N-(1-(6-(4-Ethyl-1-piperazinyl)-3-pyridinyl)-1-methylethyl)-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide. Grade: >98%. CAS No. 566161-24-8. Molecular formula: C28H30FN5O2. Mole weight: 487.57. | |
| BMS582949 | BMS582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 value of 13nM, which plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β. It is used for the treatment of rheumatoid arthritis. It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms582949 is used for the treatment of rheumatoid arthritis. Synonyms: 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide; BMS-582949; PS-540446; BMS 582949; PS 540446; BMS582949; PS540446. Grade: 98%. CAS No. 623152-17-0. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grade: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| BMS-585248 | BMS585248 is a highly potent and novel human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with 4-fluoro-6-azaindole core heterocycles. It targets the viral envelope protein gp120. It showed much improved in vitro potency and pharmacokinetic properties than the previous clinical candidate BMS488043. Uses: Bms585248 targets the viral envelope protein gp120. Synonyms: BMS-585248; 619331-12-3; UNII-CIO2TZZ9H1; CIO2TZZ9H1; 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo(2,3-C)pyridin-3-yl)-; BMS 585248; 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione; Piperazine, 1-benzoyl-4-((4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo(2,3-C)pyridin-3-yl)oxoacetyl)-; 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-(1,2,3)triazol-1-yl-1H-pyrrolo(2,3-c)pyridin-3-yl)ethane-1,2-dione; CHEMBL236995; SCHEMBL2628937; AKOS040750870; BMS-585428; DA-71584; HY-13829; CS-0007961; Q27275484; 1-(4-benzoyl-piperazin-1-yl)-2-(4-fluoro-7-(1,2,3)triazol-1-yl-1H-pyrrolo(2,3-c)pyridin-3-yl)-ethane-1,2-dione; Piperazine, 1-benzoyl-4-[2-[4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-. Grade: 98%. CAS No. 619331-12-3. Molecular formula: C26H21Cl2N3O6S. Mole weight: 574.4. | |
| BMS587101 | BMS-587101 is an LFA-1 small-molecule antagonist. It could reduce inflammation and joint destruction in murine models of arthritis. It inhibited LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production in vitro. It is developed by Bristol Myers Squibb research. It is used for the treatment of moderate to severe psoriasis. It was in phase II clinical trials, but has been terminated. Uses: Bms-587101 is used for the treatment of moderate to severe psoriasis. Synonyms: BMS-587101; BMS 587101; BMS587101; UNII-5V7E4UQL93. 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acid. Grade: 98%. CAS No. 509083-77-6. Molecular formula: C26H20Cl2N4O4S. Mole weight: 555.43. | |
| BMS-593214 | BMS-593214 is an active-site, direct FVIIa inhibitor. It displayed direct, competitive inhibition of human FVIIa in the hydrolysis of a tripeptide substrate with Ki of 5 nM. Synonyms: BMS593214; BMS 593214; 2'-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid. Grade: >98%. CAS No. 1004551-40-9. Molecular formula: C31H27N3O4. Mole weight: 505.56. | |
| BMS 599626 dihydrochloride | BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 = 22 nM and 32 nM, respectively), and also inhibits HER4 (IC50 = 190 nM). BMS 599626 displays 100-fold selectivity for EGFR and ErbB2 over VEGFR2, c-Kit, Lck, MET etc MEK and Lck. It can be used as an antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Synonyms: BMS599626 dihydrochloride; BMS-599626 dihydrochloride; AC480 dihydrochloride; AC 480 dihydrochloride; AC-480 dihydrochloride; (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:2); (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1781932-33-9. Molecular formula: C27H27FN8O3.2HCl. Mole weight: 603.48. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride is a selective and efficacious orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases with potential antineoplastic activity. It inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: AC480 hydrochloride; AC 480 hydrochloride; AC-480 hydrochloride; BMS-599626 HCl; BMS-599626 monohydrochloride; BMS 599626 Hydrochloride; BMS599626 hydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1); Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)imino)-5-methyl-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride. Grade: >98%. CAS No. 873837-23-1. Molecular formula: C27H28ClFN8O3. Mole weight: 567.01. | |
| BMS-604992 dihydrochloride | BMS-604992 dihydrochloride is a selective and orally active growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). It stimulates feeding in rodents. Synonyms: EX-1314 dihydrochloride; Carbamic acid, N-(2-amino-2-oxoethyl)-N-methyl-, [3-[(1S)-1-[(2-amino-2-methyl-1-oxopropyl)amino]-2-(phenylmethoxy)ethyl]-1,2,4-triazolo[4,3-a]pyridin-5-yl]methyl ester, dihydrochloride (1:2). CAS No. 1469750-46-6. Molecular formula: C24H33Cl2N7O5. Mole weight: 570.47. | |
| BMS-604992 free base | BMS-604992 free base is a selective and orally active growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). It stimulates feeding in rodents. Synonyms: EX-1314 free base; Carbamic acid, (2-amino-2-oxoethyl)methyl-, [3-[(1S)-1-[(2-amino-2-methyl-1-oxopropyl)amino]-2-(phenylmethoxy)ethyl]-1,2,4-triazolo[4,3-a]pyridin-5-yl]methyl ester; (3-{(1S)-2-(Benzyloxy)-1-[(2-methylalanyl)amino]ethyl}[1,2,4]triazolo[4,3-a]pyridin-5-yl)methyl (2-amino-2-oxoethyl)methylcarbamate. Grade: ≥95%. CAS No. 760944-56-7. Molecular formula: C24H31N7O5. Mole weight: 497.55. | |
| BMS 605541 | BMS 605541 is a potent and ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM) displaying >10-fold selectivity for VEGFR-2 over VEGFR-1. It exhibits antitumor activity in human lung and colon tumor xenograft models. Synonyms: BMS-605541; BMS 605541; BMS605541. N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide. Grade: ≥98% by HPLC. CAS No. 639858-32-5. Molecular formula: C19H17F2N5OS. Mole weight: 401.43. | |
| BMS-626529 | BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. Research result suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound. Synonyms: BMS626529; BMS 626529; BMS-626529; Temsavir. Grade: 98%. CAS No. 701213-36-7. Molecular formula: C24H23N7O4. Mole weight: 473.493. | |
| BMS639623 | BMS639623 is a CCR3 antagonist with picomolar inhibition potency against eosinophil chemotaxis. It may be used for the treatment of asthma. Uses: Bms639623 may be used for the treatment of asthma. Synonyms: BMS-639623; BMS 639623; Urea, N-((1R,2S)-3-((3S)-3-((4-fluorophenyl)methyl)-1-piperidinyl)-2-hydroxy-1-methylpropyl)-N'-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)-. Grade: 98%. CAS No. 675122-44-8. Molecular formula: C25H32FN7O2. Mole weight: 481.57. | |
| BMS-641988 | BMS-641988 is a nonsteroidal androgen receptor (AR) antagonist with anti-androgenic and potential antineoplastic activities. BMS-641988 binds to ARs in target tissues and prevents AR activation, which may result in the inhibition of AR-mediated transcriptional activity and tumor cell death in susceptible tumor cell populations. Synonyms: BMS641988; BMS 641988; Ethanesulfonamide, N-((3aR,4R,5R,7R,7aS)-2-(4-cyano-3-(trifluoromethyl)phenyl)octahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-1H-isoindol-5-yl)-. CAS No. 573738-99-5. Molecular formula: C20H20F3N3O5S. Mole weight: 471.45. | |
| BMS-645737 | BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. Synonyms: BMS645737; BMS 645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine. Grade: >98%. CAS No. 651744-16-0. Molecular formula: C20H20N8O. Mole weight: 388.43. | |
| BMS-663068 | BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Synonyms: Fostemsavir; BMS-663068; BMS 663068; BMS663068. Grade: >98%. CAS No. 864953-29-7. Molecular formula: C25H26N7O8P. Mole weight: 583.49. | |
| BMS-663068 Tris | BMS-663068 tris is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. Synonyms: Fostemsavir Tris; Fostemsavir tromethamine; BMS-663068 Tris; BMS 663068 Tris; BMS663068 Tris. Grade: >98%. CAS No. 864953-39-9. Molecular formula: C29H37N8O11P. Mole weight: 704.62. | |
| BMS-663749 | BMS-663749 is HIV-1 attachment inhibitor. Uses: Hiv. Synonyms: BMS-663749; BMS 663749; BMS663749; UNII-667A5745M0; SCHEMBL2688950; CHEMBL2219875; (3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl dihydrogen phosphate. Grade: 98%. CAS No. 864953-33-3. Molecular formula: C23H25N4O9P. Mole weight: 532.44. | |
| BMS-6690514 | BMS-690514 is a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3. BMS-690514 is currently under investigation as an oral agent for the treatment of solid tumors. The preclinical ADME properties of BMS-690514 suggest good oral bioavailability in humans and metabolism by multiple pathways including oxidation and glucuronidation. Synonyms: BMS-6690514; BMS 6690514; BMS6690514. Grade: 0.98. CAS No. 859853-30-8. Molecular formula: C19H24N6O2. Mole weight: 368.441. | |
| BMS-687453 | BMS-687453 is a potent and selective peroxisome proliferator activated receptor PPARα agonist. with an IC50 of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. Synonyms: BMS-687453; BMS 687453; BMS687453. Grade: 98%. CAS No. 1000998-59-3. Molecular formula: C22H21ClN2O6. Mole weight: 444.87. | |
| BMS 688521 | BMS 688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1). It has provided proof-of-concept for LFA-1 as an immunological target. BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively), which inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model. Synonyms: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid; BMS-688521; BMS688521; SCHEMBL5392413. Grade: ≥98%. CAS No. 893397-44-9. Molecular formula: C26H19Cl2N5O4. Mole weight: 536.37. | |
| BMS694153 | BMS694153 is a potent and selective calcitonin gene-related peptide(CGRP) receptor antagonist. It is related with the pathogenesis of migraine. Uses: Bms694153 is related with the pathogenesis of migraine. Synonyms: BMS-694153; BMS 694153; BMS694153; (R)-N-(1-([1,4'-bipiperidin]-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide; (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide; 4-(8-Fluoro-2-oxo-1,4-dihydroquinazolin-3-yl)-N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-piperidin-1-ylpiperidin-1-yl)propan-2-yl]piperidine-1-carboxamide. Grade: >98 %. CAS No. 1050381-35-5. Molecular formula: C35H45FN8O3. Mole weight: 644.79. | |
| BMS695735 | BMS695735 is a benzimidazole inhibitor of the insulin-like growth factor-1 receptor. It was also found to have potent CYP3A4 inhibition. It has broad spectrum in vivo antitumor activity. Uses: Bms695735 has broad spectrum antitumor activity. Synonyms: BMS-695735; BMS 695735; BMS695735; CHEMBL459729; BDBM27888; DNC008930; 2(1H)-Pyridinone, 4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-3-(5-(1-(3-fluoropropyl)-4-piperidinyl)-7-methyl-1H-benzimidazol-2-yl)-; (3Z)-4-[2-(4-chloropyrazol-1-yl)ethylamino]-3-[6-[1-(3-fluoropropyl)piperidin-4-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one. Grade: 95%. CAS No. 1054315-48-8. Molecular formula: C26H31ClFN7O. Mole weight: 512.02. | |
| BMS-707035 | BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Uses: Hiv integrase inhibitors. Synonyms: BMS-707035; BMS-707035; BMS-707035. Grade: >98%. CAS No. 729607-74-3. Molecular formula: C17H19FN4O5S. Mole weight: 410.42. | |
| BMS711939 | BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPARα. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation. Uses: Bms711939 was chosen for further preclinical evaluation. Synonyms: BMS-711939; BMS 711939; BMS711939. Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; 2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]acetic acid. Grade: >98 %. CAS No. 1000998-62-8. Molecular formula: C22H20ClFN2O6. Mole weight: 462.86. | |
| BMS-740808 | BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa with Ki of 0.03 nM. Synonyms: 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-[2-[[(3R)-3-hydroxypyrrolidin-1-yl]methyl]phenyl]phenyl]-3-(trifluoromethyl)-4,5-dihydropyrazolo[3,4-c]pyridin-7-one; BMS 740808; BMS-740808; BMS740808; UNII-LDD74E663F. Grade: >99%. CAS No. 280118-23-2. Molecular formula: C31H27F3N6O3. Mole weight: 588.58. | |
| BMS 753 | BMS 753 is a RARα-selective agonist (Ki = 2 nM) that modulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1). Synonyms: BMS753; BMS 753; BMS-753. 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid. Grade: ≥99% by HPLC. CAS No. 215307-86-1. Molecular formula: C21H21NO4. Mole weight: 351.4. | |
| BMS-753426 | BMS-753426 is a potent and orally bioavailable CCR2 antagonist. Synonyms: BMS753426; BMS 753426; N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-((6-(trifluoromethyl)quinazolin-4-yl)amino)pyrrolidin-1-yl)cyclohexyl)acetamide. CAS No. 1004536-52-0. Molecular formula: C25H33F3N6O2. Mole weight: 506.56. | |
| BMS-754807 | BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways. Synonyms: BMS754807; BMS-754807; BMS 754807. Grade: 0.98. CAS No. 1001350-96-4. Molecular formula: C23H24FN9O. Mole weight: 461.505. | |
| BMS-777607 | BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor. It shows antitumor activity, inducing apoptosis and decreasing proliferation and migration. Synonyms: BMS817378; BMS 817378; BMS-817378; BMS 777607; BMS777607; ASLAN 002; ASLAN-002; ASLAN002. CAS No. 1025720-94-8. Molecular formula: C25H19ClF2N4O4. Mole weight: 512.893. | |
| BMS779333 | BMS779333 is a novel AR pan-antagonist with significantly improved cardiovascular and metabolic profiles. It has anti- tumor effect. Uses: Bms779333 has anti- tumor effect. Synonyms: BMS-779333; BMS779333; BMS 779333; UNII-3MJN2P4998. Benzonitrile, 4-((3aR,4S,6R,6aS,8aS,8bR)-octahydro-4-hydroxy-6-methyl-7-oxo-3a,6-epoxy-3ah-pyrano(2,3,4-cd)isoindol-8(4H)-yl)-2-(trifluoromethyl)-. Grade: >98%. CAS No. 1095181-60-4. Molecular formula: C19H17F3N2O4. Mole weight: 394.35. | |
| BMS-779788 | BMS-779788 is a LXR partial agonist with IC50 values of 68 nM and 14 nM for LXRα and LXRβ respectively. BMS-779788 induces LXR target genes in blood in vivo with EC50 value of 610 nM, and significantly increases plasma triglyceride and LDL cholesterol. Synonyms: BMS-779788; BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652; ; 2-[2-[2-(2-chlorophenyl)propan-2-yl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol. CAS No. 918348-67-1. Molecular formula: C28H29ClN2O3S. Mole weight: 509.061. | |
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