BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
×
Product
Description
Suppliers Website
Cgp-33304
Cgp-33304 is a dual phospholipase A2 inhibiting agent and leukotriene receptor antagonists. It may prevent hypoxia secondary to leukotriene induced bronchoconstriction in shock states. It has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Uses: Cgp-33304 has potential to be an useful therapeutic agent in acute ischemic disorders including traumatic shock. Synonyms: Cgp 33304; Cgp33304; Cgp-33304; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-bromo-2-methylphenyl)-, monosodium salt; CGP33304; N-(3-(3-(4-Acetyl-3-hydroxy-2-n-propylphenoxy)propoxy)-4-bromo-6-methylphenyl)-1H-tetrazole-5-carboxamide sodium; Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-bromo-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grade: >98%. CAS No. 111130-14-4. Molecular formula: C23H25BrN5NaO5. Mole weight: 554.38.
CGP 3466B maleate
CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) but the clinical trials have been terminated due to lack of benefit. Synonyms: N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine; but-2-enedioic acid; Omigapil maleate; CGP 3466B; CGP-3466B; CGP3466B; TCH-346; TCH 346; TCH346; Omigapil maleate. Grade: >99 %. CAS No. 200189-97-5. Molecular formula: C23H21NO5. Mole weight: 391.42.
CGP 35348
CGP 35348 is a selective and brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes) with higher affinity for postsynaptic than presynaptic receptors. Synonyms: CGP35348; CGP-35348; (3-Aminopropyl)(diethoxymethyl)phosphinic acid. Grade: 95% by NMR. CAS No. 123690-79-9. Molecular formula: C8H20NO4P. Mole weight: 225.22.
Cgp-35949
Cgp-35949 is an LTD4 antagonist which has phospholipase inhibitory activity. It represents a new approach to the treatment of asthma. Uses: Cgp-35949 represents a new approach to the treatment of asthma. Synonyms: Cgp 35949; Cgp-35949; Cgp35949; 1H-Tetrazole-5-carboxamide, N-(5-(3-(4-acetyl-3-hydroxy-2-propylphenox y)propoxy)-4-chloro-2-methylphenyl)-, monosodium salt; CGP35949; N-(5-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)-1H-tetrazole-5-carboxamide monosodium salt; Sodium N-[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-chloro-2-methylphenyl]-1,2,3-triaza-4-azanidacyclopenta-2,5-diene-5-carboxamide; Sodium 5-((5-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy)-4-chloro-2-methylphenyl)carbamoyl)tetrazol-1-ide. Grade: >98%. CAS No. 111130-13-3. Molecular formula: C23H25ClN5NaO5. Mole weight: 509.92.
CGP 36216
CGP 36216 hydrochloride is a selective GABAB antagonist that is active to presynaptic receptors but inactive to postsynaptic receptors. Synonyms: CGP 36216 hydrochloride; CGP36216 hydrochloride; CGP-36216 hydrochloride; (3-Aminopropyl)ethylphosphinic acid hydrochloride. Grade: ≥99% by HPLC. CAS No. 123691-29-2. Molecular formula: C5H14NO2P. Mole weight: 151.14.
CGP 36216 hydrochloride
CGP 36216 is a selective GABA antagonist with IC50 of 43 μM, which is active at the presynaptic but not postsynaptic. Synonyms: CGP 36216. Grade: ≥98%. CAS No. 1781834-71-6. Molecular formula: C5H14NO2P·HCl. Mole weight: 187.6.
CGP 36742
CGP 36742 is a selective antagonist of GABAB receptor that can penetrate the blood-brain barrier after peripheral administration, with an IC50 of 32 μM. It can be used to study depression, seizures and metabolic diseases. Uses: Gaba antagonists. Synonyms: SGS-742; (3-Aminopropyl)(n-butyl)phosphinic acid; 3-aminopropyl-butylphosphinic acid; Phosphinic acid, P-(3-aminopropyl)-P-butyl-; Phosphinic acid, (3-aminopropyl)butyl-; P-(3-Aminopropyl)-P-butyl-phosphinic acid. Grade: 95%. CAS No. 123690-78-8. Molecular formula: C7H18NO2P. Mole weight: 179.20.
CGP 37157
CGP 37157 is a a selective sodium-calcium exchanger inhibitor with IC50 value of 0.36 μM in isolated mitochondria. It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum. CGP 37157 can be used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis. Synonyms: Cgp 37157; Cgp-37157; Cgp37157. 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one. Grade: 98%. CAS No. 75450-34-9. Molecular formula: C15H11Cl2NOS. Mole weight: 289.78.
CGP 37849
CGP 37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). CGP 37849 exhibits an anticonvulsant effect following oral administration in vivo. Synonyms: CGP37849; CGP 37849; CGP-37849; (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid. Grade: ≥99% by HPLC. CAS No. 127910-31-0. Molecular formula: C6H12NO5P. Mole weight: 209.14.
Cgp 38560
Cgp 38560 is a potent renin inhibitor and it can induce a dose-dependent decrease in angiotensin II and plasma renin activity and a long-lasting and dose-dependent rise in active renin. Although reduction of plasma renin activity to unmeasurable levels, the doses used did not reduce plasma angiotensin II maximally. Synonyms: Cgp 38560; Cgp38560; Cgp-38560. (R)-N-(2-(((1,1-dimethylethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)-L-histidyl-3-cyclohexyl-L-alanyl-N-butyl-L-Valinamide monomethanesulfonate. Grade: 98%. CAS No. 122088-76-0. Molecular formula: C39H64N6O9S2. Mole weight: 825.09.
CGP 39551
Cgp 39551 is a selective and competitive N-methyl-D-aspartate (NMDA) receptor antagonist originated by Novartis. Ki is 310 nM for inhibition of [3H]-CPP binding in rat brain. CGP 39551 produces excitatory effects and causes psychotomimetic effects in humans. Treatment for Craniocerebral trauma, Epilepsy and Stroke was discontinued. Uses: Craniocerebral trauma, epilepsy and stroke. Synonyms: Cgp 39551; Cgp39551; Cgp-39551; (E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester; CGP 39551; (E)-(-)-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester. Grade: 98%. CAS No. 127910-32-1. Molecular formula: C8H16NO5P. Mole weight: 237.19.
Cgp 39653
Cgp 39653 is a competitive N-Methyl-D-aspartate (NMDA) receptor antagonist. CGP 39653 can selectively bins to the NMDA receptor as an antagonist with high affinity. It is currently the ligand of choice for labeling the NMDA receptor. Uses: The ligand of choice for labeling the nmda receptor. Synonyms: Cgp 39653; Cgp-39653; Cgp-39653; (R,Z)-2-amino-4-(phosphonomethyl)hept-3-enoic acid. Grade: 98%. CAS No. 132472-31-2. Molecular formula: C8H16NO5P. Mole weight: 237.19.
CGP-42454A
CGP-42454A is a epimer of Benazepril ,an approved drug using for the treatment of Hypertension. Synonyms: CGP-42454A; CGP 42454A; CGP42454A; UNII-15B0UK1949; 2-((R)-3-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid. Grade: 98%. CAS No. 131064-74-9. Molecular formula: C24H28N2O5. Mole weight: 424.49.
CGP 43182
CGP 43182, a dioxaspiro compound, has been found to a IIA sPLA2 inhibitor that could have potential anti-inflammatory effect and also in influencing the synergistic effect brought by pro-inflammatory genes. Synonyms: Cgp 43182; Cgp-43182; Cgp43182. N-(2,3-Dichlorophenyl)-2-hydroxy-4-oxo-1,5-dioxaspiro(5.5)undec-2-ene-3-carboxamide; N-(2,3-dichlorophenyl)-2-hydroxy-4-oxo-1,5-dioxaspiro[5.5]undec-2-ene-3-carboxamide; AC1L2SHN; DTXSID00164535. Grade: 98%. CAS No. 150379-37-6. Molecular formula: C16H15Cl2NO5. Mole weight: 372.20.
CGP 43487
CGP 43487 has been found to be a NMDA receptor antagonist and was once studied about its influenment of dopaminergic function as a supplement in the treatment of Parkinson's disease. Synonyms: Cgp 43487; Cgp43487; Cgp-43487; [(E,4R)-4-amino-5-ethoxy-2-methyl-5-oxopent-2-enyl]phosphonic acid. Grade: 98%. CAS No. 146388-56-9. Molecular formula: C8H16NO5P. Mole weight: 237.19.
Cgp 43902A
Cgp 43902A is a bio-active molecular, but no detailed information has been published yet. Synonyms: Cgp 43902A; Cgp43902A; Cgp-43902A. ethyl 2-[(4Z)-5-(hydroxymethyl)-2-methyl-3-oxo-4-[(2-pyridin-2-ylhydrazinyl)methylidene]pyridin-1-ium-1-yl]acetate; bromide. Grade: 98%. CAS No. 124076-31-9. Molecular formula: C17H21BrN4O4. Mole weight: 425.28.
Cgp 45688
Cgp 45688 is an non-steroidal aromatase inhibitor originated byNovartis. It has anti-tumor effects, but no development for treatment of cancer was reported. Uses: Cancer. Synonyms: Cgp 45688; Cgp45688; Cgp-45688. 4,4'-(2H-tetrazol-2-ylmethylene)bis-Benzonitrile. Grade: 98%. CAS No. 134520-88-0. Molecular formula: C16H10N6. Mole weight: 286.30.
CGP 46381
CGP 46381 is a selective GABAB receptor antagonist (IC50 = 4.9 μM). Synonyms: (3-Aminopropyl)(cyclohexylmethyl)phosphinic Acid; P-(3-Aminopropyl)-P-(cyclohexylmethyl)phosphinic Acid. CAS No. 123691-14-5. Molecular formula: C10H22NO2P. Mole weight: 219.26.
CGP 47072
CGP 47072, a bisphosphonate derivative, has been found to be a calcium regulator and was once studied in the treatment of osteoporosis. Synonyms: Cgp 47072; Cgp47072; Cgp-47072.CHEMBL101886; AC1L4IPT; SCHEMBL7164644; [1-hydroxy-3-[methyl(3-phenoxypropyl)amino]-1-phosphonopropyl]phosphonic acid. Grade: 98%. CAS No. 158859-42-8. Molecular formula: C13H23NO8P2. Mole weight: 383.27.
Cgp 47645
Cgp 47645 is non-steroidal aromatase inhibitor with anti-tumor and endocrine effects. It is orally active. Uses: Anti-tumor. Synonyms: Cgp 47645; Cgp47645; Cgp-47645; Leflutrozole; UNII-RCX0IE6EJZ; 4,4'-(fluoro-1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile. Grade: 98%. CAS No. 143030-47-1. Molecular formula: C17H10FN5. Mole weight: 303.30.
CGP 48369
Cgp 48369 is a nonpeptide a angiotensin type 1 receptor antagonist originated by Novartis. Treatmenf for for Hypertension in Switzerland was discontinued in 1995. Uses: Hypertension. Synonyms: Cgp 48369; Cgp48369; Cgp-48369. 5-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,6-dibutylpyrimidin-4(1H)-one. Grade: 98%. CAS No. 135689-23-5. Molecular formula: C26H30N6O. Mole weight: 442.56.
CGP 52411
CGP 52411, also called DAPH, inhibits and reverses the formation of Aβ42 fibers (β-sheet content of aggregated β-amyloid (1-42): IC50 = 4.5 μM) in neurons associated with Alzheimer's disease. And it is also a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP 52411; CGP52411; CGP-52411; 5,6-dianilinoisoindole-1,3-dione; 406-050-3; Z13D008FZ2; 4,5-dianilinophthalimide; DAPH; Cgp 52411; 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione; 145915-58-8; Cgp-52411; UNII-Z13D008FZ2; CHEMBL268868; 5,6-dianilino-1h-isoindole-1,3(2h)-dione; CHEBI:53110; Z13D008FZ2; AC1Q6JME; DAPH-1; SCHEMBL11017; 4,5-Bis(anilino)phthalimide; D3943_SIGMA; 4,5-bis-(anilino)phthal. CAS No. 145915-58-8. Molecular formula: C20H15N3O2. Mole weight: 329.35.
CGP 52432
CGP52432 is a potent and selective GABAB receptor antagonist with IC50 value of 85 nM. Synonyms: Cgp 52432; Cgp52432; Cgp52432; 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid. Grade: >98 %. CAS No. 139667-74-6. Molecular formula: C15H24Cl2NO4P. Mole weight: 384.24.
CGP-53153
CGP-53153 is a steroidal inhibitor of 5 alpha reductase is a steroidal which effects the conversion of testosterone (T) to 5α-dihydrotestosterone (DHT). In vitro, CGP 53153 competitively inhibited rat microsomal 5α-reductase from prostate by 50% (ICs0) at a concentration of 36 nM compared to the reference compound finasteride which inhibited 5α-reductase with an ICs0 of 11 nM in the same system. In vivo, inhibition of 5α-reductase activity was characterized in three different test systems. Synonyms: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-(2-cyanopropan-2-yl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; wt1-ricin a; SCHEMBL8823373; CGP 53153; CGP-53153; CGP53153. CAS No. 149281-19-6. Molecular formula: C23H33N3O2. Mole weight: 383.53.
CGP 53353
CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM). It inhibits de novo Aβ42 assembly in vitro. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP53353; CGP 53353; CGP-53353. 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; DAPH 2; CGP-53353; 145915-60-2; DAPH-7; PKCbetaII/EGFR Inhibitor; CHEMBL7939; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; IN1137; 4,5-bis(4-Fluoroanilino)-phthalimide; CGP 53 353; CG53353; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; DAPH-2; MolMap_000016; C7866_SIGMA; SCHEMBL230492; GTPL5163; CTK8E9235; RONQPWQYDRPRGG-UHFFFAOYSA-N; HMS3229K07; HMS3269E05; ZINC600430; CGP53353; BDBM50040930; CGP 53353; DNC003638; MFCD00938569; AKOS015911570; CCG-206784; NCGC00159569-01; NCGC00159569-02; AK394840; HE005407; HE312152; ZB014534; DB-042814; FT-0643387; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis-(4-fluoro-phenylamino)-isoindole-1,3-dione; BRD-K32292990-001-01-0; I14-37922; 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione; CGP 53353|5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione. CAS No. 145915-60-2. Molecular formula: C20H13F2N3O2
CGP 53820
CGP 53820 has been found to be a HIV-1 Protease pseudosymmetric inhibitor that could probably be effective in the treatment of HIV infections. Synonyms: cgp 53820; 149267-24-3; Cgp-53820; ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL; (2S)-2-acetamido-N-[(2S,3S)-4-[[[(2S)-2-acetamido-3-methylbutanoyl]amino]-(cyclohexylmethyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-methylbutanamide; C20; 1hih; (S)-2-acetamido-N-((2S,3S)-4-(2-((S)-2-acetamido-3-methylbutanoyl)-1-(cyclohexylmethyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-yl)-3-methylbuta. Grade: 98%. CAS No. 149267-24-3. Molecular formula: C31H51N5O5. Mole weight: 573.77.
CGP 54626 hydrochloride
The hydrochloride salt form of CGP 54626, a dichloropheny derivative, has been found to be a GABAB receptor antagonist that could probably be effective as an analgesic agent. IC50: 4 nM. Synonyms: CGP 54626 hydrochloride; CGP54626 hydrochloride; CGP-54626 hydrochloride; CGP 54626 HYDROCHLORIDE; [S-(R*,R*)]-[3-[[1-(3,4-DICHLOROPHENYL)ETHYL]AMINO]-2-HYDROXYPROPYL](CYCLOHEXYLMETHYL) PHOSPHINIC ACID HYDROCHLORIDE; (S-(R*,R*))-(3-((1-(3,4-Dichlorophenyl)ethyl)amino)-2-hydroxypropyl)-([3.4-3H]-cyclohexylmethyl)phosphinicacid; [3. Grade: 98%. CAS No. 149184-21-4. Molecular formula: C18H28Cl2NO3P.HCl. Mole weight: 410.31.
CGP 55802A
CGP 55802A has been found to be a photoaffinity ligand that could be used to label NMDA receptor and have high selectivity to glutamate recognition site. Synonyms: Cgp-55802A; Cgp 55802A; (E)-2-Amino-10-((4-azido-2-hydroxy-3-iodobenzoyl)amino)-4-(phosphonomethyl)-3-decenoic acid monosodium salt; 152564-63-1; 2-Amino-10-((4-azido-2-hydroxy-3-iodobenzoyl)amino)-4-phosphonomethyl-dec-3-enoic acid sodium salt; 3-Decenoi. Grade: 98%. CAS No. 152564-63-1. Molecular formula: C18H24IN5NaO7P. Mole weight: 603.29.
CGP 55845 hydrochloride
CGP 55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM), which prevents agonist binding (pKi = 8.35) and inhibits release of GABA and glutamate (pEC50 = 8.08 and 7.85, respectively). Synonyms: CGP 55845 HCl; CGP 55845HCl; CGP 55845; CGP55845; CGP-55845; (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride. Grade: ≥98% by HPLC. CAS No. 149184-22-5. Molecular formula: C18H22Cl2NO3P.HCl. Mole weight: 438.71.
CGP 57380
CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. Synonyms: CGP-57380; CGP57380; CGP 57380. Grade: >98%. CAS No. 522629-08-9. Molecular formula: C11H9FN6. Mole weight: 244.23.
CGP 57813
CGP 57813 has been found to be a HIV-1 protease inhibitor that has been once developed by Novartis. Synonyms: Cgp 57813; Cgp-57813; Cgp57813; Carbamic acid, (2-hydroxy-4-((4-methoxyphenyl)methyl)-5-((2-methyl-1-(((2-(4-morpholinyl)-2-oxo-1-(phenylmethyl)ethyl)amino)carbonyl)propyl)amino)-5-oxo-1-(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1R*,2R*,4S*,5(. Grade: 98%. CAS No. 150608-41-6. Molecular formula: C43H58N4O8. Mole weight: 758.94.
CGP-59326
CGP-59326, a pyrrolopyrimidine derivative, has been found to be an EGFR antagonist and could used in antineoplastic studies. Synonyms: CGP-59326; CGP 59326; CGP59326; CHEMBL306081; 1H-Pyrrolo(2,3-d)pyrimidin-4-amine, N-(3-chlorophenyl)-5,6-dimethyl-; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, N-(3-chlorophenyl)-5,6-dimethyl-. Grade: 98%. CAS No. 173458-56-5. Molecular formula: C14H13ClN4. Mole weight: 272.73.
CGP60474
CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP. Synonyms: CGP-60474; CGP 60474. Grade: >98%. CAS No. 164658-13-3. Molecular formula: C18H18ClN5O. Mole weight: 355.82.
CGP-62198A
CGP-62198A, a piperidine derivative, could probably be useful in some biological studies. Synonyms: CGP-62198A; CGP 62198A; CGP62198A; UNII-WXF63HI1WD; WXF63HI1WD; SCHEMBL6042796. Benzamide, N-((2S,4S,5S,7S)-7-(((2-(4-acetyl-1-piperidinyl)ethyl)amino)carbonyl)-4-amino-5-hydroxy-8-methyl-2-(1-methylethyl)nonyl)-2-(4-methoxybutoxy)-. Grade: 98%. CAS No. 180183-51-1. Molecular formula: C35H60N4O6. Mole weight: 632.89.
Cgp 6809
Cgp 6809 is a new methylnitrosoureido-sugar derivative. It is active against a broad spectrum of transplantable tumours in mice and rats. But Phase I clinical trials for the treatment of solid tumor were discontinued. Uses: Cancer. Synonyms: Cgp 6809; Cgp6809; Cgp-6809; ethyl-6-deoxy-3,5-di-O-methyl-6-(3-methyl-3-nitrosoureido)glucofuranoside. Grade: 98%. CAS No. 84069-38-5. Molecular formula: C12H23N3O7. Mole weight: 321.33.
CGP 71683 hydrochloride
CGP 71683 hydrochloride is a highly selective non-peptide antagonist of the NPY Y(5) receptor (IC50= 1.4 nM) with > 1000-fold selectivity over Y1 (IC50= 2765 nM), Y2 (IC50= 7187 nM) and Y4 (IC50= 5637 nM) receptors. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats. Synonyms: N-[[4-[[(4-aminoquinazolin-2-yl)amino]methyl]cyclohexyl]methyl]naphthalene-1-sulfonamide; hydrochloride; CGP 71683 A; CGP-71683A; CGP 71683 hydrochloride; CGP71683 hydrochloride; CGP-71683 hydrochloride. Grade: >99 %. CAS No. 192322-50-2. Molecular formula: C26H29N5O2S.HCl. Mole weight: 512.07.
CGP74514A
CGP74514A is a cell permeable Cdk inhibitor selective for Cyclin-dependent kinase-1 (Cdk1) (IC50=25nM). CGP74514A was also reported also to affect the activities of other kinases including PKCα (IC50=6.1μM), PKA (IC50=125μM) and EGFR (IC50>10μM), but only at much higher concentrations. Synonyms: 2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine; CGP 74514A; 481724-82-7 (CGP74514A HCl salt); CGP-74514A; CGP74514A; N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine. Grade: >98%. CAS No. 190653-73-7. Molecular formula: C19H24ClN7. Mole weight: 385.9.
CGP 74514 dihydrochloride
CGP 74514 Dihydrochloride is a potent cdk1 inhibitor with IC50 of 25 nM. It can reduce Akt phosphorylation and increase mitochondrial damage in leukemia cells. Synonyms: CGP 74514. Grade: ≥98%. Molecular formula: C19H24ClN7·2HCl. Mole weight: 458.82.
CGP-75254A
CGP-75254A, a novel oral iron chelator, across Caco-2 cells in an attempt to model intestinal epithelial cell permeability in man. Studies predicted that absorption of CGP-75254A is likely to be virtually complete at pH values between 5.5 and 7.0. However, at pH 8.0 permeability is predicted as negligible. Synonyms: sodium; 2-[2-[(2-ethoxy-2-oxoethyl)-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetate; CGP-75254A; CGP 75254A; CGP75254A; UNII-94KC20I6YX; 199485-27-3 (CGP-75254A Free Acid). Grade: >98%. CAS No. 199485-26-2. Molecular formula: C22H27N2NaO6. Mole weight: 438.45.
CGP-75355
CGP-75355 is an HIV Protease inhibitor (EC50= 0.7 nM). Uses: Hiv protease inhibitors. Synonyms: CGP-75355; CGP 75355; CGP75355; UNII-4ZE7DBE752; methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-phenylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate; 232632, BMS; 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-2,5,6,10,13-pentaazatetradecanedioic acid dimethyl ester; atazanavir; atazanavir sulfate; BMS 232632; BMS 232632 05; BMS-232632; BMS-232632-05; BMS232632; BMS23263205. Grade: >98%. CAS No. 191594-64-6. Molecular formula: C39H53N5O7. Mole weight: 703.87.
CGP 76030
CGP76030 is a ual-specific Src and Abl kinase inhibitor, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases. Uses: Ual-specific src and abl kinase inhibitor. Synonyms: CGP-76030; CGP76030; CGP76030; CGP-076030. 7-(4-(2-((2-methoxyethyl)amino)ethoxy)phenyl)-5-(3-methoxyphenyl)-7H-Pyrrolo(2,3-d)pyrimidin-4-amine. Grade: ≥98%. CAS No. 497152-38-2. Molecular formula: C24H27N5O3. Mole weight: 433.5.
CGP 77675
CGP 77675 is a potent Src kinase inhibitor. It can be used to maintain mouse embryonic stem cell (mESC) in combination with CHIR99021. Uses: Protein kinase inhibitors. Synonyms: CGP-77675; 1-(4-(4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol. Grade: >98%. CAS No. 234772-64-6. Molecular formula: C26H29N5O2. Mole weight: 443.55.
CGP 78608
CGP 78608 is a potent and selective NMDA receptor antagonist that exhibits an anticonvulsant effect in vivo following systemic administration. Synonyms: Phosphonic acid, P-[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-; P-[(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid; Phosphonic acid, [(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-; Phosphonic acid, [1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-, (S)-; CGP78608; CGP-78608; [(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid; (S)-(1-(((7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)ethyl)phosphonic acid. Grade: ≥95%. CAS No. 206648-13-7. Molecular formula: C11H13BrN3O5P. Mole weight: 378.12.
CGP 78608 hydrochloride
CGP 78608 hydrochloride is a potent and selective NMDA antagonist with > 500-fold selectivity over kainate and AMPA receptors (IC50 = 2.7 and 3 μM, respectively). CGP 78608 exhibits an anticonvulsant effect in vivo following systemic administration. Synonyms: CGP78608 hydrochloride; CGP-78608 hydrochloride; [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid hydrochloride; Phosphonic acid, P-[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-, hydrochloride (1:1); (S)-(1-(((7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl)amino)ethyl)phosphonic acid hydrochloride. Grade: ≥98% by HPLC. CAS No. 1135278-54-4. Molecular formula: C11H13BrN3O5P.HCl. Mole weight: 414.58.
CGP7930
CGP7930 is a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and has a synergistic effect with GABAB agonists such as baclofen and GHB. It increases the potency and efficacy of GABA at both native and recombinant GABAB receptors with EC50 values of 5.37 and 4.60μM respectively. It also enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. It reduces operant self-administration of ethanol and cocaine in rats. Uses: Cgp7930 has anxiolytic effects in animal studies, and has a synergistic effect with gabab agonists such as baclofen and ghb. it reduces operant self-administration of ethanol and cocaine in rats. Synonyms: 3,5-Bis(1,1-dimethylethyl)-4-hydroxy-beta,beta-dimethylbenzenepropanol; 2,6-Ditert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol; 3-(3',5'-Di-tert-butyl-4'-hydroxy)phenyl-2,2-dimethylpropanol; CGP7930; CGP-7930; CGP 7930. Grade: >98 %. CAS No. 57717-80-3. Molecular formula: C19H32O2. Mole weight: 292.46.
CGP-79807
CGP-79807 is a potent CDC2 protein kinase inhibitor that originated by Novartis. In Sep 2000, Preclinical development for Cancer in Switzerland was on-going, but no development has been reported. Uses: Cancer. Synonyms: CGP-79807; CGP 79807; CGP79807; UNII-532R2SRL4B; CHEMBL172140; 532R2SRL4B; SCHEMBL5842014; SCHEMBL5842019; BDBM50073763. 3-((9-ethyl-2-((trans-4-hydroxycyclohexyl)amino)-9H-purin-6-yl)amino)-Benzonitrile. Grade: 98%. CAS No. 1229665-91-1. Molecular formula: C20H23N7O. Mole weight: 370.44.
Cgp 8716
Cgp 8716 is a major metabolite of GP53,633 which is a basic non-steroidal anti-inflammatory agent Originated by Novartis. Synonyms: Cgp 8716; Cgp8716; Cgp-8716. 4-(2-(1,1-dimethylethyl)-5-(3-pyridinyl)-1H-imidazol-4-yl)-Phenol. Grade: 98%. CAS No. 84782-21-8. Molecular formula: C18H19N3O. Mole weight: 293.36.
CGRP (83-119), rat TFA
Calcitonin Gene Related Peptide (CGRP) (83-119), rat acts through calcitonin receptor-like receptor. Synonyms: Calcitonin Gene Related Peptide(83-119), rat TFA. Molecular formula: C162H262N50O52S2.C2HF3O2. Mole weight: 3920.32.
CGRP antagonist 1
CGRP antagonist 1 is a highly potent antagonist of CGRP receptor (Ki = 35 nM; IC50 = 57 nM). Synonyms: (S)-N-(2''-oxo-1,1'',2'',3-tetrahydrospiro[indene-2,3''-pyrrolo[2,3-b]pyridine]-5-yl)-2-(2-oxo-2'',3'',5'',6''-tetrahydrospiro[indoline-3,4''-pyran]-1-yl)acetamide; Spiro[3H-indole-3,4'-[4H]pyran]-1(2H)-acetamide, 2',3',5',6'-tetrahydro-2-oxo-N-[(2S)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-; N-[(2S)-2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]-2-(2-oxo-2',3',5',6'-tetrahydrospiro[indole-3,4'-pyran]-1(2H)-yl)acetamide. Grade: ≥95%. CAS No. 1123757-49-2. Molecular formula: C29H26N4O4. Mole weight: 494.54.
CGS 12066B dimaleate
CGS 12066B dimaleate is a 5-HT1B full agonist, which is 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Uses: Serotonin receptor agonists. Synonyms: CGS 12066B dimaleate; CGS12066B dimaleate; CGS-12066B dimaleate; 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate. Grade: ≥98% by HPLC. CAS No. 109028-10-6. Molecular formula: C17H17F3N4.2C4H4O4. Mole weight: 566.49.
Cgs 15696
Cgs 15696 is an adenosine antagonist. Synonyms: 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one; 9-chloro-2-(furan-2-yl)-5H,6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one. Grade: 98% by HPLC. CAS No. 104615-00-1. Molecular formula: C13H7ClN4O2. Mole weight: 286.67.
CGS 15943
CGS 15943 is a potent and orally bioactive adenosine receptor antagonist (Ki = 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors, respectively). Synonyms: CGS 15943; CGS15943; CGS-15943; 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine. Grade: ≥99% by HPLC. CAS No. 104615-18-1. Molecular formula: C13H8ClN5O. Mole weight: 285.69.
CGS 19755
CGS 19755 is a potent and competitive NMDA receptor antagonist with anticonvulsant, anxiolytic, analgesic and neuroprotective activity. Synonyms: CGS-19755; CGS 19755; CGS19755; CPDD 0027; CPDD-0027; CPDD0027; Selfotel; cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid. CAS No. 110347-85-8. Molecular formula: C7H14NO5P. Mole weight: 223.17.
CGS 20625
CGS 20625 is a partial agonist for the benzodiazepine binding site of the GABAA receptor used as an anti-anxiety drug. It acts as a central benzodiazepine receptor agonist (IC50 = 1.3 nM) with no affinity for other neurotransmitter receptor binding sites. Uses: Anti-anxiety drug. Synonyms: CGS 20625; CGS20625; CGS-20625; 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one. Grade: ≥99% by HPLC. CAS No. 111205-55-1. Molecular formula: C18H19N3O2. Mole weight: 309.36.
CGS 21680
CGS 21680, an A2 adenosine receptor selective agonist, has been found to be probably effective in inducing vasorelaxation and increasing in heart rate. Uses: Cgs 21680 is an a2 adenosine receptor selective agonist that has been found to be probably effective in inducing vasorelaxation and increasing in heart rate. Synonyms: Cgs 21680; CGS-21680; CGS21680; 2-(4-(2-Carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; UNII-T5HB1E831H; CHEMBL331372. Grade: 95%. CAS No. 120225-54-9. Molecular formula: C23H29N7O6. Mole weight: 499.52.
CGS 21680C Sodium Salt
A selective A2A receptor agonist. Uses: A selective a2a receptor agonist. Synonyms: 4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic Acid Monosodium Salt. Grade: 95%. CAS No. 120225-64-1. Molecular formula: C23H28N7NaO6. Mole weight: 521.5.
CGS 21680 Hydrochloride
CGS 21680 Hcl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. Synonyms: CGS 21680 Hydrochloride; CGS21680 Hydrochloride; CGS-21680 Hydrochloride. Grade: >98%. CAS No. 124431-80-7. Molecular formula: C23H29N7O6.HCl. Mole weight: 535.98.
CGS 27023A
CGS 27023A is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9. Synonyms: MMI 270. CAS No. 161314-82-5. Molecular formula: C18H24ClN3O5S. Mole weight: 429.92.
CGS 35066
CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor with > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 = 22 and 2300 nM, respectively). It blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH). Synonyms: CGS 35066; CGS35066; CGS-35066; α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid; (2S)-3-dibenzofuran-3-yl-2-(phosphonomethylamino)propanoic acid. Grade: ≥99% by HPLC. CAS No. 261619-50-5. Molecular formula: C16H16NO6P. Mole weight: 349.28.
CGS 9343B
CGS 9343B is a calmodulin (CaM) antagonist that inhibits calmodulin-stimulated cAMP phosphodiesterase activity (IC50 = 3.3 nM). It also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR. Synonyms: CGS 9343B; CGS9343B; CGS-9343B; Zaldaride Maleate; 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate. Grade: ≥98% by HPLC. CAS No. 109826-27-9. Molecular formula: C26H28N4O2.C4H4O4. Mole weight: 544.61.
CH0076989
CH0076989 is a small molecule agonist for CCR3. It activates a number of signalling pathways including chemotaxis and receptor internalisation. Uses: Ch0076989 activates a number of signalling pathways including chemotaxis and receptor internalisation. Synonyms: CH-0076989; CH 0076989; CH0076989; UNII-9E629B19WL; CHEMBL485834; 9E629B19WL; 4-(2-(Benzofuran-4-yl)acetamido)-2-bromo-1-(3-phenylpropyl)pyridin-1-ium bromide. Grade: 98%. CAS No. 54371-52-9. Molecular formula: C24H22Br2N2O2. Mole weight: 530.25.
CH-0793076
CH-0793076, a hexacyclic camptothecin analog and an active drug and major metabolite of TP300, has an inhibitory effect on DNA topoisomerase I with an IC50 of 2.3 μM. It is effective against cells expressing BCRP (breast cancer resistance protein). Synonyms: TP3076; (9S)-9-ethyl-9-hydroxy-1-pentyl-1H,12H-pyrano[3'',4'':6',7']indolizino[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione; (9S)-9-Ethyl-9-hydroxy-1-pentyl-1,9,12,15-tetrahydro-10H,13H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazoline-10,13-dione; 10H,13H-Pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazoline-10,13-dione, 9-ethyl-1,9,12,15-tetrahydro-9-hydroxy-1-pentyl-, (9S)-. Grade: ≥98%. CAS No. 534605-78-2. Molecular formula: C26H26N4O4. Mole weight: 458.51.
CH-0793076 TFA
CH-0793076 TFA, a hexacyclic camptothecin analog and an active drug and major metabolite of TP300, has an inhibitory effect on DNA topoisomerase I with an IC50 of 2.3 μM. It is effective against cells expressing BCRP (breast cancer resistance protein). Synonyms: TP3076 TFA; (9S)-9-Ethyl-9-hydroxy-1-pentyl-1,9,12,15-tetrahydro-10H,13H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazoline-10,13-dione trifluoroacetate (1:1); Acetic acid, 2,2,2-trifluoro-, compd. with (9S)-9-ethyl-1,9,12,15-tetrahydro-9-hydroxy-1-pentyl-10H,13H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazoline-10,13-dione (1:1). Grade: ≥98%. Molecular formula: C28H27F3N4O6. Mole weight: 572.53.
CH100
CH100 is a Chinese herbal medicine. It is previously used in the treatment of human hepatitis C. Uses: Ch100 is used in the treatment of human hepatitis c. Synonyms: CH 100; CH-100; 2-Propanamine, N-(1-methylethyl)-, (4-chlorophenoxy)acetate; Acetic acid, (4-chlorophenoxy)-, compd. with N-(1-methylethyl)-2-propanamine (1:1). Grade: 98%. CAS No. 51346-20-4. Molecular formula: C14H22ClNO3. Mole weight: 287.78.
CH-102
CH-102 is an isoquinoline derivative. It could inhibit platelet aggregation. Uses: Ch-102 could inhibit platelet aggregation. Synonyms: CH 102; CH102; (3z)-3-imino-8,9-dimethoxy-5,6-dihydro[1,3]thiazolo[4,3-a]isoquinoline-1-carbonitrile; 5,6-Dihydro-3-imino-8,9-dimethoxythiazolo[4,3-a]isoquinoline-1-carbonitrile. Grade: 98%. CAS No. 55393-37-8. Molecular formula: C14H13N3O2S. Mole weight: 287.34.
CH 141
CH 141 is a peripheral vasodilator. Uses: Peripheral vasodilator. Synonyms: 6-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)-3-phenyl-5,6-dihydro-2H-1,2,4-oxadiazine; CH 141; CH-141; CH141; Pthiqdo. Grade: 98%. CAS No. 78279-88-6. Molecular formula: C19-H21-N3-O. Mole weight: 307.39.
CH 150
CH 150 is a bio-active chemical, but detailed information has not been published. Synonyms: CH 150; CH150; CH-150. 3-Ethyl-2,6-dimethyl-4H-pyrido(1,2-a)pyrimidin-4-one. Grade: 98%. CAS No. 70381-44-1. Molecular formula: C12H14N2O. Mole weight: 202.26.
CH-200
CH-200 is used as a new antiarrhythmic drug. It suppressed arrhythmia more effectively than did procainamide and lidocaine in beagle dogs. Uses: Ch-200 is used as a new antiarrhythmic drug. Synonyms: CH200; CH 200; 5-Phenacylthieno(3,2-c)pyridinium chloride; 5-(2-Oxo-2-phenylethyl)thieno(3,2-c)pyridinium chloride. Grade: 98%. CAS No. 64955-45-9. Molecular formula: C15H12ClNOS. Mole weight: 289.78.
CH-223191
CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant with many toxic effects, including endocrine disruption, reproductive dysfunction, immunotoxicity, liver damage, and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription. In addition, CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR. These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes, target genes of the AhR. CH-223191, may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology. Synonyms: CH223191; CH-223191; CH 223191. Grade: >98%. CAS No. 301326-22-7. Molecular formula: C19H19N5O. Mole weight: 333.39.
CH 275
CH 275 is a potent somatostatin receptor 1 (sst1) agonist (IC50 = 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). It attenuates somatostatin release in the rat nucleus accumbens. Synonyms: CH 275; CH275; CH-275. CAS No. 174688-78-9. Molecular formula: C74H96N14O15S2. Mole weight: 1485.8.