BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Cevimeline N-Oxide | A metabolite of Cevimeline. Synonyms: (2'R,3R)-rel-2'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-oxathiolane] 1-Oxide. Grade: > 95%. CAS No. 469890-14-0. Molecular formula: C10H17NO2S. Mole weight: 215.32. |  |
| Cevimeline Sulfoxide | A metabolite of Cevimeline. Synonyms: (2'R,3R,3'S)-rel-2'-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-oxathiolane] 3'-Oxide. Grade: > 95%. CAS No. 124751-36-6. Molecular formula: C10H17NO2S. Mole weight: 215.32. | |
| Cevipabulin | Cevipabulin, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, it specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Cebipabulin stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death. Synonyms: TTI 237; TTI237; TTI237; D06576. CAS No. 849550-05-6. Molecular formula: C18H18ClF5N6O. Mole weight: 464.825. | |
| Cevipabulin fumarate | Cevipabulin fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line). Synonyms: TTI-237 fumarate. Grade: 99%. CAS No. 849550-67-0. Molecular formula: C22H22ClF5N6O5. Mole weight: 580.89. | |
| Cevipabulin succinate | Cevipabulin is a Tubulin polymerisation inhibitor. It can bind to tubulin at the vinca site and promote the polymerization of tubulin into microtubules. Cevipabulin can stabilize tubulin and inhibit microtubule disassembly. This leads to cell cycle arrest at the G2/M phase. Phase I clinical trials for the treatment of solid tumor were discontinued. Uses: Solid tumours. Synonyms: TTI237; TTI 237; TTI-237; D06576; D 06576; D-06576; 5-chloro-6-(2,6-difluoro-4-(3-(methylamino)propoxy)phenyl)-N-((1S)-2,2,2-trifluoro-1-methylethyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-amine (1:1), dihydrate. Grade: 98%. CAS No. 852954-81-5. Molecular formula: C18H18ClF5N6O. Mole weight: 618.94. | |
| Cev (R)-S-oxide | Cev (R)-S-oxide is an impurity compound of Cevimeline which is a novel muscarinic M1 and M3 receptor agonist. Synonyms: trans-cevimeline sulfoxide; Cevimeline sulfoxide, trans-. CAS No. 124751-37-7. Molecular formula: C10H17NO2S. Mole weight: 215.31. | |
| CF-101 | CF101 is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. CF101 has been shown to downregulate PKB/Akt and NF-κB protein expression level. CF101 potentiates the cytotoxic effect of 5-FU, thus preventing drug resistance. The myeloprotective effect of CF101 suggests its development as an add-on treatment to 5-FU. Synonyms: CF101; CF-101; CF 101; ALB-7208; ALB 7208; ALB7208; IB MECA; Piclidenoson. CAS No. 152918-18-8. Molecular formula: C18H19IN6O4. Mole weight: 510.28. | |
| CF-102 | CF-102 is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation. Uses: Purinergic p1 receptor agonists. Synonyms: Chloro-IB-MECA; 2-Chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide; 2-Cl-IB-MECA; 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide; Namodenoson; (2S,3S,4R,5R)-5-(2-Chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide; Cl-IB-MECA; CF102; CF 102. Grade: ≥98% by HPLC. CAS No. 163042-96-4. Molecular formula: C18H18ClIN6O4. Mole weight: 544.73. | |
| CF53 | CF53 is a selective, highly potent and orally active BET protein inhibitor, with a Ki of <1 nM, Kd of 2.2 nM and IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. It has potent antitumor activity in vitro and in vivo. Synonyms: N-(3-Cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine; BET inhibitor CF53; 9H-Pyrimido[4,5-b]indol-4-amine, N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy-2-methyl-; CF53 free base. Grade: ≥98%. CAS No. 1808160-52-2. Molecular formula: C24H25N7O2. Mole weight: 443.50. | |
| CFG920 | CFG920 is a Steroid 17-alpha-hydroxylase inhibitor originated by Novartis. It has potential antiandrogen and antineoplastic activities. It may inhibit cell proliferation of androgen-dependent tumor cells. In Jan 2013, Phase-I clinical trials in Prostate cancer in Spain was on-going, but now clinical trials for Prostate cancer is discontinued. Uses: Prostate cancer. Synonyms: CFG920; CFG 920; CFG-920; 1-(2-chloropyridin-4-yl)-3-(4-methylpyridin-3-yl)imidazolidin-2-one. Grade: 98%. CAS No. 1260006-20-9. Molecular formula: C14H13ClN4O. Mole weight: 288.73. | |
| CFI-400936 | CFI-400936 is a selective proteine kinase TTK inhibitor with IC50 value of 3.6nM. It demonstrates good activity in cell based assay and selectivity against a panel of human kinases. CFI-400936 shows potential anticancer activity. Uses: Anticancer. Synonyms: CFI400936; CFI 400936; CFI-400936. 2-(dimethylamino)-2-(2-ethylphenyl)-N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)acetamide. Grade: 98%. CAS No. 1338793-07-9. Molecular formula: C25H27N5O3S. Mole weight: 477.58. | |
| CFI-401870 | CFI-401870 is a TTK (tyrosine threonine kinase) Inhibitor with IC50 value < 10 nM. CFI-401870 showed low off-target activity (>500×) and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing. It has been selected for preclinical evaluation. Uses: Anti-tumor. Synonyms: CFI-401870; CFI 401870; CFI401870; N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide. Grade: 98%. CAS No. 1430741-35-7. Molecular formula: C30H31N5O2. Mole weight: 493.61. | |
| CFI-401980 | CFI-401980, a pyrazolotriazin derivative, has been found to be a TTK inhibitor that could exhibit good antiproliferative activity in some human cancer cell lines. Ki = 0.8 nM. Synonyms: CFI-401980; CFI 401980; CFI401980; N-cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide. Grade: 98%. CAS No. 1610676-27-1. Molecular formula: C28H30N6O3. Mole weight: 498.59. | |
| CFLZ-171 formic acid salt | CFLZ-171 is an important intermediate to synthesis carfilzomib which is an anti-cancer drug acting as a selective proteasome inhibitor. Synonyms: CFLZ-171 formic acid salt; CFLZ 171 formic acid salt; CFLZ171 formic acid salt; carfilzomib intermediate molecule weight 171. 1Pentanone 2amino4methyl1(2R)2methyl2oxiranyl (2S) 222trifluoroacetate (1:1); 1Pentanone 2amino4methyl1(2R)2methyloxiranyl (2S) trifluoroacetate (9CI); S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one 2,2,2-trifluoroacetate. Grade: 98%. CAS No. 1140908-93-5. Molecular formula: C9H17NO2.CH2O2. Mole weight: 217.27. | |
| CFLZ-567 | CFLZ-567 is a key intermediate for making carfilzomib. carfilzomib is a selective proteasome inhibitor as an anti-cancer drug. Uses: Key intermediate for making carfilzomib. Synonyms: carfilzomib intermediate molecule weight 567; LPhenylalanine (S)2(4morpholinyl)acetylaminobenzenebutanoylLleucyl; LPhenylalanine (S)(4morpholinylacetyl)aminobenzenebutanoylLleucyl (9CI); (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic acid. Grade: 98%. CAS No. 868540-16-3. Molecular formula: C31H42N4O6. Mole weight: 566.69. | |
| CFM 1571 | CFM 1571 is a stimulator of nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 of 5.49 μM and IC50 of 2.84 μM. When adenylyl cyclase is not activated, it has no obvious inhibition on phosphodiesterases, and shows minimal inhibition of iNOS (25%) and nNOS (17%). It inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM), and has the potential to study cardiovascular and other diseases. Synonyms: 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide; 1H-Pyrazole-5-carboxamide, 3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1-(phenylmethyl)-; 1-Benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide; 1-benzyl-3-(3-dimethylaminopropyloxy)-5-(4-methoxyphenylaminocarbonyl)-1H-pyrazole. Grade: ≥95%. CAS No. 268725-86-6. Molecular formula: C23H28N4O3. Mole weight: 408.49. | |
| CFM 1571 hydrochloride | CFM 1571 hydrochloride is a stimulator of nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 of 5.49 μM and IC50 of 2.84 μM. When adenylyl cyclase is not activated, it has no obvious inhibition on phosphodiesterases, and shows minimal inhibition of iNOS (25%) and nNOS (17%). It inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM), and has the potential to study cardiovascular and other diseases. Synonyms: 1-Benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide Hydrochloride; 1H-Pyrazole-5-carboxamide, 3-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-, hydrochloride (1:1); 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide hydrochloride. Grade: ≥95%. CAS No. 1215548-30-3. Molecular formula: C23H29ClN4O3. Mole weight: 444.95. | |
| CFM-2 | Potent and selective AMPA antagonist. Synonyms: CFM-2; CFM 2; CFM2. Grade: >98%. CAS No. 178616-26-7. Molecular formula: C17H17N3O3. Mole weight: 311.34. | |
| CFM 4 | CFM 4 is a CARP-1 mimetic compound that inhibits CARP-1 binding to APC-2. It causes apoptosis and inhibition of cell growth in cancer cells. Synonyms: CFM-4; CFM 4; CFM4; 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one. Grade: ≥99% by HPLC. CAS No. 331458-02-7. Molecular formula: C22H16ClN3OS. Mole weight: 405.9. | |
| c-Fms-IN-1 | c-Fms-IN-1 is a c-FMS kinase inhibitor with an IC50 of 0.0008 μM. Synonyms: 5-Cyano-N-[4-(4-methyl-1-piperazinyl)-2-(1-piperidinyl)phenyl]-2-furamide; 2-Furancarboxamide, 5-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(1-piperidinyl)phenyl]-; 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide. Grade: ≥95%. CAS No. 885703-64-0. Molecular formula: C22H27N5O2. Mole weight: 393.48. | |
| c-Fms-IN-10 | c-Fms-IN-10 is a cFMS inhibitor (IC50 = 2 nM) with antitumor activity. Synonyms: 4-Amino-N-{3-methyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl}thieno[3,2-d]pyrimidine-7-carboxamide; Thieno[3,2-d]pyrimidine-7-carboxamide, 4-amino-N-[3-methyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-. Grade: ≥95%. CAS No. 1527517-50-5. Molecular formula: C22H19N7OS. Mole weight: 429.50. | |
| c-Fms-IN-2 | c-Fms-IN-2 is a c-FMS kinase inhibitor with an IC50 of 0.024 μM. Synonyms: 5-Cyanofuran-2-carboxylic Acid N-[5-hydroxymethyl-2-(4-methylpiperidin-1-yl)phenyl]amide; c-Fms inhibitor 2; 2-Furancarboxamide, 5-cyano-N-[5-(hydroxymethyl)-2-(4-methyl-1-piperidinyl)phenyl]-; 5-Cyano-N-[5-(hydroxymethyl)-2-(4-methyl-1-piperidinyl)phenyl]-2-furamide. Grade: ≥95%. CAS No. 791587-67-2. Molecular formula: C19H21N3O3. Mole weight: 339.39. | |
| c-Fms-IN-6 | c-Fms-IN-6 is a potent c-FMS inhibitor with an IC50 of ≤10 nM for unphosphorylated c-FMS. It weakly inhibits unphosphorylated c-KIT and PDGFR (IC50 >1 μM). It is used in the research of autoimmune diseases. Synonyms: 2-(5-{[2-(1-Ethyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy}-6-methyl-2-pyridinyl)-5-(2-methyl-2-propanyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-(1,1-dimethylethyl)-2-[5-[[2-(1-ethyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-6-methyl-2-pyridinyl]-2,4-dihydro-. Grade: ≥95%. CAS No. 1628574-81-1. Molecular formula: C22H25N7O2. Mole weight: 419.48. | |
| c-Fms-IN-7 | c-Fms-IN-7 is a cFMS inhibitor with an IC50 of 18.5 nM. (Extracted from patent WO2011079076A1, example159). Synonyms: N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(methylthio)imidazo[1,2-a]pyridine-3-carboxamide; N-{3-Cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl}-7-(methylsulfanyl)imidazo[1,2-a]pyridine-3-carboxamide; Imidazo[1,2-a]pyridine-3-carboxamide, N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-7-(methylthio)-. Grade: ≥95%. CAS No. 1313408-89-7. Molecular formula: C26H24N6OS. Mole weight: 468.57. | |
| c-Fms-IN-8 | c-Fms-IN-8 is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. Synonyms: (3-{4-[(4-Ethylbenzyl)oxy]-3-methoxyphenyl}-1-azetidinyl)[4-(2-hydroxyethoxy)-2-pyridinyl]methanone; Methanone, [3-[4-[(4-ethylphenyl)methoxy]-3-methoxyphenyl]-1-azetidinyl][4-(2-hydroxyethoxy)-2-pyridinyl]-. Grade: ≥95%. CAS No. 1255303-58-2. Molecular formula: C27H30N2O5. Mole weight: 462.54. | |
| c-Fms-IN-9 | c-Fms-IN-9, a c-FMS inhibitor, inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively. (Extracted from patent WO2014145023A1, Compound Example 7). Synonyms: 3-(tert-butyl)-1-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-1H-1,2,4-triazol-5(4H)-one; 2-(6-Methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy}-2-pyridinyl)-5-(2-methyl-2-propanyl)-1,2-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-(1,1-dimethylethyl)-1,2-dihydro-2-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-. Grade: ≥95%. CAS No. 1628574-50-4. Molecular formula: C21H23N7O2. Mole weight: 405.45. | |
| c-FMS inhibitor | c-FMS inhibitor is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent. Synonyms: 1H-Pyrrole-2-carboxamide, 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-. Grade: >98%. CAS No. 885704-21-2. Molecular formula: C23H30N6O. Mole weight: 406.52. | |
| cFMS Receptor Inhibitor II | cFMS Receptor Inhibitor II is a colony stimulating factor-1 receptor (CSF1R) kinase inhibitor. CSF-1 is a cytokine. Synonyms: 3-Quinolinecarboxamide, 4-[(3,4-dimethylphenyl)amino]-7-(4-pyridinyl)-; 4-((3,4-dimethylphenyl)amino)-7-(pyridin-4-yl)quinoline-3-carboxamide; 4-[(3,4-Dimethylphenyl)amino]-7-(4-pyridinyl)-3-quinolinecarboxamide. Grade: ≥99%. CAS No. 959860-85-6. Molecular formula: C23H20N4O. Mole weight: 368.43. | |
| CFT7455 | CFT7455 is an orally bioavailable MonoDAC targeting IKZF1/3 for the treatment of multiple myeloma (MM) and non-Hodgkin's lymphomas (NHL), including peripheral T-cell lymphoma (PTCL) and mantle cell lymphoma (MCL). Synonyms: Cemsidomide; CFT-7455; CFT 7455; (3S)-3-(6-((4-(Morpholin-4-ylmethyl)phenyl)methyl)-2-oxobenzo(cd)indol-1-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-(6-((4-(4-morpholinylmethyl)phenyl)methyl)-2-oxobenz(cd)indol-1(2H)-yl)-, (3S)-; (3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione; GTPL11961; GLXC-26095; (S)-CFT7455; EX-A6043; NSC840579; AKOS040758857; NSC-840579; BP-28982; MS-28680; HY-144841; CS-0435593; EN300-43393872; (3S)-3-(6-{[4-(morpholin-4-ylmethyl)phenyl]methyl}-2-oxobenz[cd]indol-1(2H)-yl]piperidine-2,6-dione; (3S)-3-[9-({4-[(morpholin-4-yl)methyl]phenyl}methyl)-3-oxo-2-azatricyclo[6.3.1.0,4,12]dodeca-1(12),4,6,8,10-pentaen-2-yl]piperidine-2,6-dione. CAS No. 2504235-67-8. Molecular formula: C28H27N3O4. Mole weight: 469.53. | |
| CFT8634 | CFT8634 is a BiDAC degrader targeting BRD9 for the treatment of cancers that are dependent on BRD9, as synovial sarcoma and SMARCB1 deleted cancers. Molecular formula: C37H45F3N6O5. Mole weight: 710.79. | |
| CFTR corrector 4 | CFTR corrector 4, an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase the level of CFTR on the cell surface and has the potential to treat cystic fibrosis. Synonyms: 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3,4-dihydro-2H-chromen-4-yl]cyclopropanecarboxamide; Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-yl]-. Grade: ≥95%. CAS No. 1918142-34-3. Molecular formula: C29H27F2NO7. Mole weight: 539.52. | |
| CFTR corrector 6 | CFTR corrector 6, a potent cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, has the potential for cystic fibrosis (CF) and other CFTR associated disorders research. Synonyms: 4-amino-7-((1-(2-fluorophenyl)-1H-pyrazol-4-yl)methyl)-5-(2-(trifluoromethyl)pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile. Grade: ≥95%. CAS No. 2226970-01-8. Molecular formula: C22H13F4N9. Mole weight: 479.39. | |
| CFTRinh-172 | CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. Synonyms: CFTR Inh-172; CFTR Inh 172; CFTR Inh172; CFTR(Inh)-172; CFTR(Inh) 172; CFTR(Inh)172; CFTR Inhibitor-172; CFTR Inhibitor 172; CFTR Inhibitor172. Grade: >98%. CAS No. 307510-92-5. Molecular formula: C18H10F3NO3S2. Mole weight: 409.4. | |
| CFZ | An antimycobacterial compound used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease. Synonyms: clofazimine; Lamprene; Lampren; Chlofazimine; N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine. Grade: 98%. CAS No. 2030-63-9. Molecular formula: C27H22Cl2N4. Mole weight: 473.4. | |
| CG200745 | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
| c[G(2',5')p-2'-AHC-A(3',5')p] | c[G(2',5')p-2'-AHC-A(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which can be used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. Synonyms: Cyclic (guanosine- (2' -≥ 5')- monophosphate- 2'- O- (6- aminohexylcarbamoyl)adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C27H38N12O14P2 (free acid). Mole weight: 816.6 (free acid). | |
| c[G(2',5')p-2'-dA(3',5')p] | c[G(2',5')p-2'-dA(3',5')p] is a 2'-deoxy analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING stimulator, which can be used for studying ligand-receptor interactions. Synonyms: Cyclic (guanosine- (2' -≥ 5')- monophosphate- 2'- deoxyadenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H24N10O12P2 (free acid). Mole weight: 658.4 (free acid). | |
| c[G(2',5')p-2'-Fluo-AHC-A(3',5')p] | c[G(2',5')p-2'-Fluo-AHC-A(3',5')p] is a fluorescent analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator. Synonyms: Cyclic(guanosine-(2'→5')-monophosphate-2'-O-(6-[fluoresceinyl]aminohexylcarbamoyl)adenosine-(3'→5')-monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C48H48N12O20P2. Mole weight: 1174.9. | |
| c[G(2',5')p-ε-A(3',5')p] | c[G(2',5')p-ε-A(3',5')p] is a fluorescent analogue of c[G(2',5')pA(3',5')p]. Grade: ≥ 95% by HPLC. Molecular formula: C22H24N10O13P2 (free acid). Mole weight: 698.4 (free acid). | |
| c[G(2',5')pG(2',5')p] | c[G(2',5')pG(2',5')p] is a cyclic dinucleotide analogue of c-diGMP, the bacterial second messenger. Synonyms: Cyclic diguanosine- (2' -≥ 5')- monophosphate / cyclic bis (2' -≥ 5') diguanylic acid, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 389873-75-0. Molecular formula: C20H24N10O14P2 (free acid). Mole weight: 690.4 (free acid). | |
| c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grade: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
| CG347B | CG347B is a selective inhibitor of histone deacetylase 6 (HDAC6). Synonyms: 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 2-[(1-phenylcyclopropyl)amino]-, ethyl ester; Ethyl 2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxylate. Grade: ≥98%. CAS No. 1598426-03-9. Molecular formula: C16H17N3O2. Mole weight: 283.33. | |
| cGAMP disodium | cGAMP diammonium activates stimulator of interferon genes (STING). cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. Synonyms: 3',3'-cGAMP disodium salt; 3'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide, disodium salt; 2',3'-CGAMP disodium salt; 3',3'-Cyclic guanosine adenosine monophosphate disodium salt; Cyclic [G(3',5')pA(3',5')p] disodium salt; Cyclic AMP-GMP disodium salt; Cyclic GMP-AMP disodium salt; Cyclic (adenosine monophosphate-guanosine monophosphate) disodium salt. Grade: 98%. CAS No. 2407516-83-8. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.37. | |
| CGC-11047 | CGC-11047 is a second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. Synonyms: CGC 11047; CGC11047; SL 11047; SL 47; SL47. CAS No. 206991-64-2. Molecular formula: C14H36Cl4N4. Mole weight: 402.27. | |
| CGH 2466 dihydrochloride | CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 = 19, 21, and 80 nM, respectively). It also displays an inhibitory effect on p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 is potentially used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Uses: Potential treatment of asthma and copd. Synonyms: CGH 2466 dihydrochloride; CGH2466 dihydrochloride; CGH-2466 dihydrochloride; 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 1177618-54-0. Molecular formula: C14H9N3SCl2.2HCl. Mole weight: 395.13. | |
| CGI1746 | CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. CGI1746 has exquisite selectivity for Btk and inhibits both auto- and transphosphorylation steps necessary for enzyme activation. Synonyms: CGI1746; CGI-1746; CGI 1746. 4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide. Grade: 98%. CAS No. 910232-84-7. Molecular formula: C34H37N5O4. Mole weight: 579.69. | |
| CGI560 | CGI560 is a potent BTK inhibitor with IC50 = 400 nM for BTK. Synonyms: CGI-560; CGI 560; 4-(tert-Butyl)-N-(3-(8-(phenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)benzamide. CAS No. 845269-74-1. Molecular formula: C29H27N5O. Mole weight: 461.57. | |
| CGK733 | CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death. Synonyms: CGK733; CGK-733; CGK 733. CAS No. 905973-89-9. Molecular formula: C23H18Cl3FN4O3S. Mole weight: 555.84. | |
| CGM097 | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Synonyms: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097. CAS No. 1313363-54-0. Molecular formula: C38H47ClN4O4. Mole weight: 659.27. | |
| cGMP | cGMP, a cyclic guanosine monophosphate, possesses an essential role in governing numerous physiological processes. Significantly employed as a pharmacological focal point in the biomedical realm to combat the likes of hypertension and pulmonary arterial hypertension, its potency is immense. Furthermore, it is intricately involved in the signal transduction pathways of selected neurotransmitters and hormones. Synonyms: Guanosine-3',5'-cyclic monophosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H12N5O7P (free acid). Mole weight: 345.20 (free acid). | |
| cGMP-AM | cGMP-AM is a precursor of cGMP, the second messenger. The polar active analogue is released after the metabolism of cGMP-AM by esterases. Synonyms: Guanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 95% by HPLC for mixture of isomers. CAS No. 164007-71-0. Molecular formula: C13H16N5O9P. Mole weight: 417.3. | |
| CGP11952 | Cgp-11952 is an experimental benzodiazepine derivative. It has affects on cognitive functioning. Uses: Cgp-11952 has affects on cognitive functioning. Synonyms: 1H-1,2,4-Triazole-3-carboxamide, 1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-[(dimethylamino)methyl]-N-ethyl-; Cgp 11952; Cgp-11952; 1-[4-Chloro-2-(2-chlorobenzoyl)phenyl]-5-[(dimethylamino)methyl]-N-ethyl-1H-1,2,4-triazole-3-carboxamide. Grade: 98%. CAS No. 64078-09-7. Molecular formula: C21H21Cl2N5O2. Mole weight: 446.33. | |
| CGP 12177 | CGP 12177 is a partial β3-adrenoceptor agonist with Ki value of 88 nM. It is also an of β1- and β2-adrenoceptors antagonist with Ki values of 0.9 nM and 4 nM for β1-, β2adrenoceptors. CGP12177 can slightly activate L-type Ca2+ current in human ventricular myocytes. Uses: Adrenergic beta-antagonists. Synonyms: CGP 12177; CGP12177; CGP-12177; Tbhpbo; CGP 12177 Hydrochloride; CGP 12177 HCl. 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one; 64208-32-8(hydrochloride). Grade: 98%. CAS No. 81047-99-6. Molecular formula: C14H21N3O3. Mole weight: 279.34. | |
| CGP 12177 hydrochloride | CGP 12177 hydrochloride is a partial agonist of β3-adrenoceptors, and also an antagonist of β1- and β2-adrenoceptors (Ki = 0.9, 4 and 88 nM for β1, β2 and β3 receptors respectively). Synonyms: CGP 12177 hydrochloride; CGP12177 hydrochloride; CGP-12177 hydrochloride; 4-[3-[(1,1-Dimethylethyl)amino]2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one hydrochloride. CAS No. 64208-32-8. Molecular formula: C14H21N3O3.HCl. Mole weight: 315.8. | |
| CGP-12388 | CGP-12388 is a beta-adrenoceptor antagonist-derived radioligands. It is used for cardiac PET imaging due to its high hydrophilicity and affinity to beta-adrenoceptor. Uses: Cgp-12388 is used for cardiac pet imaging due to its high hydrophilicity and affinity to beta-adrenoceptor. Synonyms: 4-(3-(Isopropylamino)-2-Hydroxypropoxy)-2H-Benzimidazol-2-One; Cgp 12388; Cgp-12388; Cgp12388; 2H-Benzimidazol-2-one, 4-(3-(isopropylamino)-2-hydroxypropoxy)-; 4-[2-hydroxy-3-(propan-2-ylamino)propoxy]benzimidazol-2-one. Grade: 95%. CAS No. 108929-47-1. Molecular formula: C13H19N3O3. Mole weight: 263.29. | |
| Cgp 13143 | Cgp 13143 is a bio-active chemical,but no detailed information has been published yet. Synonyms: Cgp 13143; Cgp13143; Cgp-13143. ((4-methyl-2-oxo-2H-1-benzopyran-6-yl)amino)oxo-Acetic acid. Grade: 98%. CAS No. 75919-69-6. Molecular formula: C12H9NO5. Mole weight: 247.21. | |
| Cgp 13231 | Cgp 13231 is the N-oxide metabolite of amocarzine. Synonyms: Cgp 13231; Cgp13231; Cgp-13231. 1-Piperazinecarbothioamide, 4-methyl-N-(4-((4-nitrophenyl)amino)phenyl)-4-oxide. Grade: 98%. CAS No. 113962-61-1. Molecular formula: C18H21N5O3S. Mole weight: 387.46. | |
| CGP 13501 | CGP 13501 is a positive allosteric modulator of GABAB receptors, potentiating the effects of GABA at this receptor type. Uses: Gaba-b receptor agonists. Synonyms: CGP13501; CGP 13501; CGP-13501; 3,5-bis(1,1-Dimethylethyl)-4-hydroxy-α,α-dimethylbenzenepropanal. Grade: ≥98% by HPLC. CAS No. 56189-68-5. Molecular formula: C19H30O2. Mole weight: 290.44. | |
| Cgp 15425 | Cgp 15425 is a bio-active chemical,but no detailed information has been published yet. Synonyms: Cgp 15425; Cgp15425; Cgp-15425. (S)-N1-((2S,5S,8R,11S,14S,17S)-8-((1H-indol-3-yl)methyl)-11-(4-aminobutyl)-5,17-dibenzyl-14-((R)-1-hydroxyethyl)-19-imino-3,6,9,12,15,18,22-heptaoxo-1-phenyl-4,7,10,13,16-pentaazadocosan-2-yl)-2-aminosuccinamide. Grade: 98%. CAS No. 76080-70-1. Molecular formula: C56H69N11O10. Mole weight: 1056.21. | |
| CGP-15720 hydrochloride | CGP-15720 is a antitumor agent. Uses: Antitumor. Synonyms: CGP-15720 hydrochloride; CGP-15720 HCl; CGP-15720A; CGP15720A; UNII-73G6V7978M. 4-(3-(2-(2-(pyridin-4-yl)-4,5-dihydro-1H-imidazol-1-yl)ethyl)ureido)benzoic acid hydrochloride. Grade: 98%. CAS No. 76692-12-1. Molecular formula: C18H20ClN5O3. Mole weight: 389.84. | |
| Cgp-17520 | Cgp-17520 is a new bio-active cephalosporin anti-biotic chemical comound synthesized by Ciba Geigy Ltd. Synonyms: Cgp 17520; Cgp-17520; Cgp17520. 7-(2-(4-(((2-Amino-2-carboxyethoxy)carbonyl)amino)phenyl)-2-hydroxyacetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Grade: >98 %. CAS No. 101706-66-5. Molecular formula: C22H24N8NaO9S2. Mole weight: 631.59. | |
| CGP-1758 monomethanesulfonate | CGP-1758 monomethanesulfonate is a new bio-active cephalosporin anti-biotic chemical comound synthesized by Ciba Geigy Ltd. Synonyms: CGP 1758B; CGP-1758B; CGP1758B. 2-Hydroxy-5-[2-[[2-hydroxy-3-[4-(2-methoxyethoxy)phenoxy]propyl]amino]ethoxy]benzamide monomethanesulfonate; CGP1758 monomethanesulfonate. Grade: >98%. CAS No. 108289-44-7. Molecular formula: C22H32N2O10S. Mole weight: 516.56. | |
| Cgp 20309 | Cgp 20309 has a thiocarbonylamides structure and it is a potent antifilarial agent under laboratory research stage. Uses: Antifilarial agent. Synonyms: Cgp 20309; Cgp20309; Cgp-20309. N-(2-(1,1-dimethylethyl)-5-methoxy-6-benzothiazolyl)-4-methyl-1-Piperazinecarbothioamide. Grade: 98%. CAS No. 122378-48-7. Molecular formula: C18H26N4OS2. Mole weight: 378.56. | |
| CGP 20376 | CGP 20376 is a benzothiazole compound and it has antifilarial properties. Uses: Antifilarial agent. Synonyms: CGP 20376; CGP20376; CGP-20376. 3-((((2-(1,1-dimethylethyl)-5-methoxy-6-benzothiazolyl)amino)thioxomethyl)thio)-Propanoic acid; N-(2-tert-Butyl-5-methoxybenzothiazol-6-yl)dithiocarbonic acid 5-(1-carboxyethyl)ether. Grade: 98%. CAS No. 81059-04-3. Molecular formula: C16H20N2O3S3. Mole weight: 384.54. | |
| CGP 20712 dihydrochloride | CGP 20712 dihydrochloride is a potent and selective β1-adrenoceptor antagonist (IC50 = 0.7 nM) with 10,000-fold selectivity over β2-adrenoceptors. Synonyms: CGP 20712A Dihydrochoride; CGP 20712ADihydrochoride; CGP 20712A; CGP20712A; CGP-20712A. SR-01000076208; 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride. Grade: ≥96% by HPLC. CAS No. 1216905-73-5. Molecular formula: C23H25F3N4O5.2HCl. Mole weight: 567.39. | |
| Cgp 21833 | Cgp 21833 has a thiocarbonylamides structure and it is a potent antifilarial agent under laboratory research stage. Uses: Antifilarial agent. Synonyms: Cgp 21833; Cgp-21833; Cgp21833. 1-(2-(1,1-dimethylethyl)-5-methyl-6-benzothiazolyl)-2-methylhydrazide 1-Piperazinecarbothioic acid. Grade: 98%. CAS No. 122378-49-8. Molecular formula: C18H27N5S2. Mole weight: 377.57. | |
| CGP 23996 | CGP 23996 is a non-reducible somatostatin analog. It can be used for autoradiography. Uses: Autoradiography. Synonyms: CGP 23996; CGP23996; CGP-23996. BDBM82467; 2-Deamino-L-Abu(1)-L-Lys-L-Asp(NH2)-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L-Tyr-L-Thr-L-Ser-L-Abu(1)-OH; (14R,20S,23R,26R,29R,32R)-2,17-bis(4-aminobutyl)-5-(2-amino-2-oxoethyl)-8,11-dibenzyl-20,26-bis[(1S)-1-hydroxyethyl]-29-(hydroxymethyl)-23-[(4-hydroxyphenyl)methyl]-14-(1H-indol-3-ylmethyl)-3,6,9,12,15,18,21,24,27,30,38-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazacyclooctatriacontane-32-carboxylic acid. Grade: 98%. CAS No. 86170-12-9. Molecular formula: C73H99N15O18. Mole weight: 1474.66. | |
| CGP 25454A | CGP 25454A is a selective antagonist of presynaptic dopamine autoreceptor. Synonyms: N-(diethylaminoethyl)-4-chloro-5-cyano-2-methoxybenzamide hydrochloride; Benzamide, 4-chloro-5-cyano-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:1); CGP-25454A; CGP25454A. Grade: ≥95%. CAS No. 104391-26-6. Molecular formula: C15H21Cl2N3O2. Mole weight: 346.25. | |
| Cgp 29030A | This molecular is a piperazine derivative and its Pharmacological activity probablely is inhibition on nociceptive dorsal horn neurons that processed input from high-threshold mechanosensitive receptors in the skin and deep somatic tissues.It may be used to treat painful disorders which are complicated by increased motor. activity. Uses: Treat painful disorders. Synonyms: Cgp 29030A; Cgp29030A; Cgp-29030A. 1-p-chlorophenethyl-4-(3,5-dimethoxybenzoyl)piperazine hydrochloride. Grade: 98%. CAS No. 113240-27-0. Molecular formula: C21H26Cl2N2O3. Mole weight: 425.35. | |
| Cgp 31358 | CGP 31358 is a compound that can bind to a site on the N-methyl-D-aspartate (NMDA) receptor which is coupled to both the transmitter recognition site and the channel domain.It can be a tool for researching the molecular pharmacology of this receptor-channel complex. Uses: A tool for researching the molecular pharmacology of receptor-channel complex. Synonyms: Cgp 31358; Cgp-31358; Cgp31358; 1-(4-(1-(4-chlorophenyl)-1-methylethyl)-2-methoxyphenyl)-1H-1,2,4-Triazole-3-carboxamide. Grade: 98%. CAS No. 125652-47-3. Molecular formula: C19H19ClN4O2. Mole weight: 370.83. | |
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