BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Fexofenadine impurity L | An impurity of Fexofenadine. Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 12 nM and exhibits anti-inflammatory effects. Synonyms: (Z)-4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-buten-1-yl]-α,α-dimethyl-benzeneacetic Acid. Grade: > 95%. Molecular formula: C32H37NO3. Mole weight: 483.66. |  |
| Fexofenadine N-oxide | An impurity of Fexofenadine, which is a histamine H1 receptor antagonist used for the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. Synonyms: 4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-oxido-1-piperidinyl]butyl]-α,α-dimethylbenzeneacetic acid. Grade: ≥95%. CAS No. 1422515-52-3. Molecular formula: C32H39NO5. Mole weight: 517.67. | |
| Fexofenadine USP Related Compound B | Fexofenadine USP Related Compound B is an impurity of Fexofenadine, which is a histamine H1 receptor antagonist used for the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. Synonyms: USP Fexofenadine Related Compound B; 3-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl benzeneacetic acid hydrochloride monohydrate; 2-(3-{1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid hydrochloride monohydrate; Fexofenadine EP impurity B hydrochloride monohydrate; Benzeneacetic acid, 3-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride, hydrate (1:1:1); 2-[3-[(1RS)-1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl]phenyl]-2-methylpropanoic Acid Hydrochloride Monohydrate; 2-[3-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid hydrochloride hydrate. Grade: ≥95%. Molecular formula: C32H39NO4.HCl.H2O. Mole weight: 556.13. | |
| Fezagepras sodium | Fezagepras sodium is an orally active GPR40 agonist, as well as an antagonist or inverse agonist of GPR84, with anti-fibrotic, anti-inflammatory and anti-proliferative effects. It reduces fibrosis in the renal, liver and pancreas. Synonyms: Setogepram sodium; PBI-4050 sodium; 3-Pentylbenzenacetic acid sodium salt; Benzeneacetic acid, 3-pentyl-, sodium salt (1:1). Grade: ≥95%. CAS No. 1254472-97-3. Molecular formula: C13H17NaO2. Mole weight: 228.26. | |
| Fezakinumab | Fezakinumab is a human monoclonal antibody that targets interleukin-22. Fezakinumab has been developed for the treatment of psoriasis and rheumatoid arthritis. Synonyms: ILV 094; ILV-094; ILV094. CAS No. 1007106-86-6. | |
| Fezolinetant | Fezolinetant is a neurokinin 3 receptor (NK3R) antagonist used to treat sex hormone-related diseases. Synonyms: Fezolinetant; 1629229-37-3; ESN364ESN-364; UNII-83VNE45KXX. Grade: ≥98% by HPLC. CAS No. 1629229-37-3. Molecular formula: C16H15FN6OS. Mole weight: 358.4. | |
| FF-10101 | FF-10101 is a FLT3 inhibitor that shows excellent efficacy against AML cells with FLT3 mutations. Uses: Protein kinase inhibitors. Synonyms: FF-10101; 1472797-69-5; (S,E)-N-(1-((5-(2-((4-Cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide; 7V7IHI0SYG; UNII-7V7IHI0SYG; Ff-10101-01; 2-Butenamide, N-((1S)-2-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)-5-pyrimidinyl)-4-pentyn-1-yl)amino)-1-methyl-2-oxoethyl)-4-(dimethylamino)-N-methyl-, (2E)-; CHEMBL4650283; SCHEMBL15584726; SCHEMBL16443760; BDBM397428; BCP23613; s8899; AKOS040733173; US9987278, Compound Reference 38; HY-109584; CS-0032038; FF 10101; FF10101; D87147; (E)-N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-4-(dimethylamino)-N-methylbut-2-enamide. CAS No. 1472797-69-5. Molecular formula: C29H38N8O2. Mole weight: 530.66. | |
| FF-10102-01 | FF-10102-01 is a novel and selective inhibitor of spleen tyrosine kinase (Syk). Syk plays a role in downstream pathways in signaling from B-cell receptor (BCR) in B cells and Fc-gamma receptors in macrophages. FF-10102-01 exhibits an inhibitory effect on the phosphorylation of SLP76 and ERK1/2 in THP-1 cells, and on inflammation as well as thrombocytopenia. FF-10102-01 is promisingly to be a drug used for the treatment of autoimmune disease. Uses: The potential treatment of autoimmune disease. | |
| FFN 102 mesylate | FFN 102 mesylate is a selective dopamine transporter (DAT) and VMAT2 substrate with no significant binding to a panel of 38 CNS receptors. Synonyms: FFN 102 mesylate; FFN102 mesylate; FFN-102 mesylate; 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate. Grade: ≥99% by HPLC. CAS No. 1883548-92-2. Molecular formula: C11H11N2ClO3.CH3SO3H. Mole weight: 335.76. | |
| FFN 200 dihydrochloride | FFN 200 dihydrochloride is a selective fluorescent VMAT2 substrate that traces exocytosis in dopaminergic neuronal cell culture and brain tissue. Synonyms: FFN 200 dihydrochloride; FFN200 dihydrochloride; FFN-200 dihydrochloride; 4-(2-Aminoethyl)-7-amino-2H-1-benzopyran-2-one dihydrochloride. Grade: ≥98% by HPLC. CAS No. 2080306-27-8. Molecular formula: C11H14Cl2N2O2. Mole weight: 277.15. | |
| FFN 206 dihydrochloride | FFN 206 dihydrochloride is a fluorescent VMAT2 substrate (IC50 app = 1.15 μM) that detects VMAT2 activity in intact cells. Synonyms: FFN 206 dihydrochloride; FFN206 dihydrochloride; FFN-206 dihydrochloride; 4-(2-Aminoethyl)-7-(methylamino)-2H-1-benzopyran-2-one dihydrochloride. Grade: ≥99% by HPLC. CAS No. 1883548-88-6. Molecular formula: C12H14N2O2.2HCl. Mole weight: 291.17. | |
| FFN 511 | FFN 511 is a fluorescent false neurotransmitter (FFN) targeting neuronal vesicular monoamine transporter (VMAT) 2 to inhibit serotonin binding to VMAT2 (IC50 = 1 μM). Synonyms: FFN 511; FFN511; FFN-511; 9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]-benzopyrano[6,7,8-ij]quinolizin-11-one. Grade: ≥99% by HPLC. CAS No. 1004548-96-2. Molecular formula: C17H20N2O2. Mole weight: 284.35. | |
| FG-2216 | FG-2216, also known as YM311, is an orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo. Synonyms: FG 2216; FG2216; YM311; YM-311; YM 311; N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycine. Grade: 98%. CAS No. 223387-75-5. Molecular formula: C12H9ClN2O4. Mole weight: 280.66. | |
| FG 7142 | FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. FG 7142 increases tyrosine hydroxylation and upregulates β-adrenoceptors in mouse cerebral cortex. Uses: Anxiogenic agent. Synonyms: FG 7142; FG7142; FG-7142; N-Methyl-β-carboline-3-carboxamide. Grade: ≥99% by HPLC. CAS No. 78538-74-6. Molecular formula: C13H11N3O. Mole weight: 225.25. | |
| FG8119 | FG8119 is a novel benzodiazepine agonist. Synonyms: 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one; 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5a)(1,4)benzodiazepine; COMeIB; FG 8119; FG-8119. CAS No. 106447-61-4. Molecular formula: C17H15N5O2. Mole weight: 321.33. | |
| FGF-401 | FGF-401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) (IC50 = 1.9 nM) developed for the treatment of solid tumor. Synonyms: FGF401; FGF-401; FGF 401; roblitinib; N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide. CAS No. 1708971-55-4. Molecular formula: C25H30N8O4. Mole weight: 506.56. | |
| FGFR1/DDR2 inhibitor 1 | FGFR1/DDR2 inhibitor 1 is an orally active fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2) inhibitor, with IC50s of 31.1 and 3.2 nM, respectively. It has antitumor activity. Synonyms: 3-(3-(1-Cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide; Benzamide, 3-[3-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]-. Grade: ≥95%. CAS No. 2308497-58-5. Molecular formula: C28H22F3N5O. Mole weight: 501.50. | |
| FGFR1 inhibitor-2 | FGFR1 inhibitor-2, an inhibitor of FGFR1 (IC50 = 4.55 μM in MDA-MB-231 cells), is used in the study of metastatic triple-negative breast cancer. Synonyms: Urea, N-[5,5-bis(4-fluorophenyl)pentyl]-N'-[4-nitro-3-(trifluoromethyl)phenyl]-. CAS No. 2410612-08-5. Molecular formula: C25H22F5N3O3. Mole weight: 507.45. | |
| FGFR4-IN-1 | FGFR4-IN-1 is a potent and selective FGFR4 inhibitor with potential for the treatment of gastric cancer. Synonyms: N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide; FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1. CAS No. 1708971-72-5. Molecular formula: C24H27N7O5. Mole weight: 493.52. | |
| FGFR4-IN-4 | FGFR4-IN-4 is an inhibitor of FGFR4 with antitumor activity. (Extracted from patent WO2018113584A1). Synonyms: N-((3R,4S)-4-((6-(2,6-Dichloro-3,5-dimethoxyphenyl)-8-(4-methoxypiperidin-1-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)tetrahydrofuran-3-yl)acrylamide; 2-Propenamide, N-[(3R,4S)-4-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-(4-methoxy-1-piperidinyl)pyrido[3,4-d]pyrimidin-2-yl]amino]tetrahydro-3-furanyl]-. Grade: ≥95%. CAS No. 2230973-67-6. Molecular formula: C28H32Cl2N6O5. Mole weight: 603.50. | |
| FGFR4-IN-5 | FGFR4-IN-5, a potent and selective covalent FGFR4 inhibitor (IC50 = 6.5 nM), has strong antitumor activity in vivo and can be used in hepatocellular carcinoma studies. Synonyms: 2-Propenamide, N-[(3R,4S)-4-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-7,8-dihydro-8-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]tetrahydro-3-furanyl]-; N-[(3R,4S)-4-{[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}tetrahydro-3-furanyl]acrylamide. Grade: ≥98%. CAS No. 1628793-01-0. Molecular formula: C23H23Cl2N5O5. Mole weight: 520.37. | |
| FGFR-IN-1 | FGFR-IN-1 is a potent inhibitor of FGFR with IC50s of <100 nM for FGFR1, FGFR2 and FGFR3, respectively. (Extracted from patent US20130338134A1, example 219). Synonyms: 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(hydroxymethyl)-7-(phenylsulfonyl)-; 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(hydroxymethyl)-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one. Grade: ≥95%. CAS No. 1513860-41-7. Molecular formula: C26H24F2N4O6S. Mole weight: 558.55. | |
| FGH10019 | FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM, 5-10 times lower than the IC50 of fatostatin (~10 μM). Synonyms: FGH10019; FGH 10019; FGH-10019. Grade: >98%. CAS No. 1046045-61-7. Molecular formula: C18H19N3O2S2. Mole weight: 373.49. | |
| FGI-106 | FGI-106, a potent and broad-spectrum inhibitor, has inhibitory activity against a variety of viruses with EC50s of 100, 800 and 400-900 nM against Ebola, Rift Valley and Dengue Fever viruses, respectively. It also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 and 150 nM, respectively. Synonyms: Quino[8,7-h]quinoline-1,7-diamine, N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethyl-; N,N'-Bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine; NSC-306365; N1,N7-Bis[3-(dimethylamino)propyl]-3,9-dimethylquino[8,7-h]quinoline-1,7-diamine. Grade: ≥95%. CAS No. 501081-38-5. Molecular formula: C28H38N6. Mole weight: 458.64. | |
| FGIN-1-27 | FGIN-1-27 is a high affinity agonist of mitochondrial benzodiazepine receptors (PBR) binding to benzodiazepine receptors on mitochondrial membranes. FGIN-1-27 indirectly potentiates GABAA receptor signaling to exhibit anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models. Synonyms: FGIN-1-27; FGIN 1 27; FGIN-1 27; FGIN 1-27; FGIN127; N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide; 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide. Grade: ≥98% by HPLC. CAS No. 142720-24-9. Molecular formula: C28H37FN2O. Mole weight: 436.61. | |
| FGIN-1-43 | FGIN-1-43 is a potent and specific ligand for the mitochondial DBI receptor (MDR). Synonyms: FGIN-1-43; FGIN 1 43; FGIN 1-43; FGIN-1 43; FGIN143; N,N-Dihexyl-2-(4-chlorophenyl)-5-chloroindole-3-acetamide; 2-[5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide. Grade: ≥98%. CAS No. 145040-29-5. Molecular formula: C28H36Cl2N2O. Mole weight: 487.51. | |
| FH535 | FH535 is a Wnt/β-catenin signaling inhibitor. It was shown to inhibit proliferation and motility of various cancer stem cells including liver cancer stem cells and colon cancer cells. Synonyms: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide. Grade: >98%. CAS No. 108409-83-2. Molecular formula: C13H10Cl2N2O4S. Mole weight: 361.20. | |
| FH535 sodium salt | FH535 sodium salt is a dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, leading to the inhibition of proliferation and motility of multiple cancer cells. Synonyms: FH535 sodium salt; FH 535 sodium salt; FH-535 sodium salt; (2,5-dichlorophenyl)sulfonyl-(2-methyl-4-nitrophenyl)azanide sodium salt. Grade: 99%. Molecular formula: C13H9Cl2N2NaO4S. Mole weight: 383.18. | |
| FHD-286 | FHD-286 is a potent and selective inhibitor of BRG1 and BRM. It blocks the activity of BRG1 and BRM, thus stops the growth of AML or MDS. Synonyms: FHD 286; FHD286; 1H-Pyrrole-3-carboxamide, N-((1S)-2-((4-(6-((2R,6S)-2,6-dimethyl-4-morpholinyl)-2-pyridinyl)-2-thiazolyl)amino)-1-(methoxymethyl)-2-oxoethyl)-1-(methylsulfonyl)-; N-((S)-1-(4-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-ylamino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide; N-[(2S)-1-[[4-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide. CAS No. 2671128-05-3. Molecular formula: C24H30N6O6S2. Mole weight: 562.66. | |
| FI-700 | FI-700 is a novel and potent FLT3 inhibitor with promising antileukemia activity. FI-700 showed a potent IC(50) value against FLT3 kinase at 20 nmol/L in an in vitro kinase assay. FI-700 showed selective growth inhibition against mutant FLT3-expressing leukemia cell lines and primary acute myeloid leukemia cells, whereas it did not affect the FLT3 ligand (FL)-driven growth of Wt-FLT3-expressing cells. Oral administration of FI-700 induced the regression of tumors in a s.c. tumor xenograft model and increased the survival of mice in an i.v. transplanted model. Furthermore, FI-700 treatment eradicated FLT3/ITD-expressing leukemia cells, both in the peripheral blood and in the bone marrow. Synonyms: FI700; FI 700. CAS No. 866883-79-6. Molecular formula: C21H29N9O. Mole weight: 423.53. | |
| Fiacitabine | Fiacitabine is a selective inhibitior of DNA replication of herpes simplex virus(HSV). It was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. Uses: Antineoplastic agents. Synonyms: 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine; 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinocytidine; FICA; DRG-0077; DRG 0077; DRG0077; FOAC; Fluoroiodoaracytidine; Fluorviodoaracytidine; 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one; 1-β-D-2'-Fluoroarabino-5-iodocytosine; 2'-Fluoro-5-iodo-1-β-D-arabinofuranosylcytosine; NSC 382097. Grade: ≥95%. CAS No. 69123-90-6. Molecular formula: C9H11FIN3O4. Mole weight: 371.10. | |
| Fialuridine | Fialuridine (FIAU) is a thymidine-based nucleoside analog with antiviral activity. Fialuridine and its metabolites blocks DNA synthesis in human cytomegalovirus and hepatitis B, as well as herpes simplex. Uses: Antiviral agents. Synonyms: 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine; FIAU; Fluoroiodoarauracil; 5-Iodo-2'-Fluoroarauracil; NSC 678514; 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione; 1-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)-5-iodouracil. Grade: ≥95%. CAS No. 69123-98-4. Molecular formula: C9H10FIN2O5. Mole weight: 372.09. | |
| Fialuridine 5'-Monophosphate | Fialuridine 5'-Monophosphate (FIAUMP) is the phosphorylated derivative and major metabolite of the antiviral agent Fialuridine. Studies show that purified mammalian DNA polymerases were able to incorporate FIAUMP into the nascent DNA chain during in vitro DNA synthesis. Synonyms: 1-(2-Deoxy-2-fluoro-5-O-phosphono-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione. CAS No. 99891-31-3. Molecular formula: C9H11FIN2O8P. Mole weight: 452.07. | |
| Fibrinopeptide A, human acetate | Fibrinopeptide A, human, located at the NH2-termini of the Aα chain, is a short peptide with 16 residues cleaved from fibrinogen by thrombin. Synonyms: Human fibrinopeptide A acetate. Molecular formula: C65H101N19O28. Mole weight: 1596.65. | |
| Fibroblast Growth Factor | Fibroblast Growth Factors are a family of cell signalling proteins produced by macrophages, consisting of 23 members in humans. They have various functions so that is involved in multiple processes, regulating fundamental developmental pathways. Synonyms: FGF. | |
| Fibroblast Growth Factor-Basic | Fibroblast Growth Factor-Basic is a growth factor encoded by the FGF2 gene. It is found in basement membranes and sub-endothelial extracellular matrix. FGF2 specifically binds to fibroblast growth factor receptor (FGFR) proteins. Synonyms: hBFGF; FGF-Basic; Basic fibroblast growth factor; bFGF. CAS No. 106096-93-9. | |
| Fibronectin Active Fragment Control acetate | Fibronectin Active Fragment Control acetate is an active peptide fragment of fibronectin, a glycoprotein that interacts with integrins. Synonyms: Glycyl-N5-(diaminomethylene)-L-ornithylglycyl-L-α-glutamyl-L-serine acetate. Molecular formula: C20H36N8O11. Mole weight: 564.55. | |
| Ficlatuzumab | Ficlatuzumab is a humanized monoclonal antibody that binds to hepatocyte growth factor (HGF), resulting in inhibtion of c-Met signaling pathway. Ficlatuzumab has been approved for the treatment of head and neck cancer. CAS No. 1174900-84-5. | |
| FICT-FF-FMK | FICT-FF-FMK is a fluorescein isothiocyanate (FITC)-conjugated inhibitor of cathepsin B and cathepsin L, which can be used for detecting cathepsin B and cathepsin L in live cells. Synonyms: FICT-Phe-Phe-FMK; FICT-Phe-Phe-Fluoromethylketone. Grade: >95%. Molecular formula: C41H34FN3O6S. Mole weight: 715.80. | |
| FICZ | High affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 p M). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro. Synonyms: Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-; 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde; 6-Formylindolo[3,2-b]carbazole. Grade: >98%. CAS No. 172922-91-7. Molecular formula: C19H12N2O. Mole weight: 284.31. | |
| Fidarestat | Fidarestat is a aldose reductase inhibitor originated by Sanwa Kagaku Kenkyusho. It was very effective in significantly alleviating some symptoms of diabetic polyneuropathy. Long-term treatment with SNK-860 has a beneficial preventive effect on the development of experimental diabetic neuropathy. In addition, Fidarestat is also a promising drug targeting autophagy in Colorectal Carcinoma. Uses: Diabetic neuropathies. Synonyms: SNK860; SNK-860; SNK 860; SK860; SK-860; SK 860; Fidarestat; Aldos. (2S,4S)-6-fluoro-2',5'-dioxospiro[chromane-4,4'-imidazolidine]-2-carboxamide; Aldos; SNK 860. Grade: 98%. CAS No. 136087-85-9. Molecular formula: C12H10FN3O4. Mole weight: 279.23. | |
| FIDAS-3 | FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with IC50 of 4.9 μM for MAT2A. FIDAS-3 exhibits anticancer activity. Synonyms: FIDAS-3; 1266684-01-8; (E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline; CHEMBL2153098; SCHEMBL11895457; SCHEMBL11895458; YBJDCOLXJYDHOM-DHZHZOJOSA-N; BDBM102424; EX-A7537; NSC783761; AKOS040733162; NSC-783761; MS-23652; HY-136145; CS-0119764; trans-2,6-difluoro-4'-(N,N-dimethylamino)stilbene. CAS No. 1266684-01-8. Molecular formula: C16H15F2N. Mole weight: 259.29. | |
| Fiduxosin | Fiduxosin is a potent antagonist of α1-adrenoceptor, with Ki= 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively. Fiduxosin was found to have improved uroselectivity relative to tamsulosin. Synonyms: 3-[4-[(3aR,9bR)-9-methoxy-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]butyl]-8-phenyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione; 3-(4-(9-methoxy-1,2,3,3a,4,9b-hexahydro(1)benzopyran(3,4-c)pyrrol-2-yl)butyl)-8-phenylpyrazino(2',3'-4,5)thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione; ABT 980; ABT-980; ABT980; fiduxosin. CAS No. 208993-54-8. Molecular formula: C30H29N5O4S. Mole weight: 555.65. | |
| Fiduxosin hydrochloride | Fiduxosin hydrochloride is an alpha(1)-adrenoceptor antagonist used for the treatment of benign prostatic hyperplasia. Synonyms: 3-[4-[(3aR,9bR)-9-methoxy-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]butyl]-8-phenyl-1H-pyrazino[1,2]thieno[3,4-b]pyrimidine-2,4-dione; hydrochloride; Fiduxosin hydrochloride; Fiduxosin HCl; 208993-54-8 (Fiduxosin) ; 208992-74-9 ( Fiduxosin Hydrochlride). Grade: >98%. CAS No. 208992-74-9. Molecular formula: C30H29N5O4S.HCl. Mole weight: 592.11. | |
| Figitumumab | Figitumumab is a monoclonal antibody that targets the insulin-like growth factor type I receptor (IGF1R). Figitumumab binds to IGF1R, resulting in a reduction in receptor expression on tumor cells that express IGF1R and inhibition of tumor growth. Synonyms: CP-751871. CAS No. 943453-46-1. | |
| FIIN-1 | FIIN-1 is a potent, irreversible and selective FGFR inhibitor with IC50s of 9.2, 6.2, 11.9 and 189 nM against FGFR1/2/3/4, respectively. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8, 6.9, 5.4, 120 nM and 32, 120 nM, respectively. Synonyms: FGFR irreversible inhibitor-1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide; Fibroblast Growth Factor Receptor Irreversible Inhibitor 1; N-[3-[[3-(2,6-Dichloro-3,5-dimethoxyphenyl)-7-[[4-(diethylamino)butyl]amino]-3,4-dihydro-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]acrylamide. Grade: ≥95%. CAS No. 1256152-35-8. Molecular formula: C32H39Cl2N7O4. Mole weight: 656.60. | |
| FIIN-2 | FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. Synonyms: FIIN2; FIIN 2; FIIN-2. Grade: 98%. CAS No. 1633044-56-0. Molecular formula: C35H38N8O4. Mole weight: 634.73. | |
| FIIN-3 | FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. Synonyms: FIIN3; FIIN 3; FIIN-3. Grade: 98%. CAS No. 1637735-84-2. Molecular formula: C34H36Cl2N8O4. Mole weight: 691.61. | |
| Filaminast | Filaminast is a Type 4 cyclic nucleotide phosphodiesterase inhibitor. It is an analog of rolipram which served as a prototype molecule for several development efforts. In Oct 1999, phase II clinical trials for Asthma in European Union was discontinued. Uses: Asthma. Synonyms: UNII-CDD69JC61J; Way-pda-641; WAY-PDA 641; WAY-PDA-641; CDD69JC61J; SCHEMBL73843; 1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime. Grade: 98%. CAS No. 141184-34-1. Molecular formula: C15H20N2O4. Mole weight: 292.33. | |
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grade: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
| Filanesib TFA | Filanesib TFA is a selective inhibitor of kinesin spindle protein (KSP) (IC50 = 6 nM for human KSP), with potent anti-proliferative activity. It induces cell death by apoptosis in vitro. Synonyms: ARRY-520 TFA; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate; Acetic acid, 2,2,2-trifluoro-, compd. with (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (1:1). CAS No. 1781834-99-8. Molecular formula: C22H23F5N4O4S. Mole weight: 534.50. | |
| Filapixant | Filapixant is a purinoreceptor antagonist extracted from patent WO2016091776A1, example 348. Grade: 98%. CAS No. 1948232-63-0. Molecular formula: C24H26F3N5O3S. Mole weight: 521.56. | |
| Filgotinib | Filgotinib is a potent and selective JAK1 inhibitor exhibiting 30-fold selectivity over JAK2. It was shown to inhibit Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. Filgotinib has the potential for the treatment of rheumatoid arthritis and possibly other immune-inflammatory diseases. Synonyms: 1206101-20-3; Filgotinib; GLPG0634; 1206161-97-8; GLPG-0634; N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; Filgotinib (GLPG0634); N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide; Filgotinib(GLPG0634); GS-6034 FREE BASE; 3XVL385Q0M; N-[5-[4-[(1,1-Dioxido-4-thiomorpholiny. Grade: >98%. CAS No. 1206161-97-8. Molecular formula: C21H23N5O3S. Mole weight: 425.50. | |
| Filociclovir | Filociclovir is a broad-spectrum anti-herpesvirus compound with good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8, with EC50 values ranging from 0.7 μM to 8 μM. Uses: Filociclovir is antiviral drug candidate and is used for the treatment of cytomegalovirus infection. Synonyms: Cyclopropavir; ZSM-I-62; MBX-400; 2-Amino-9-[(Z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-3H-purin-6-one; (Z)-2-amino-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-1,9-dihydro-6H-purin-6-one; (Z)-9-((2,2-bis-(Hydroxymethyl)cyclopropylidene)methyl)guanine; (Z)-2-amino-9-((2,2-bis(hydroxymethyl)cyclopropylidene)methyl)-1H-purin-6(9H)-one. Grade: 98%. CAS No. 632325-71-4. Molecular formula: C11H13N5O3. Mole weight: 263.26. | |
| Filorexant | Filorexant, a selective reversible and orally bioavaliable antagonist of OX(1)R receptor and OX(2)R receptor, could probably be an effective compound in the treatment of insomnia. It is still under the Phase II trial by Merck. Binding Ki: less than 3 nM. Uses: Filorexant, a selective reversible and orally bioavaliable antagonist of ox(1)r receptor and ox(2)r receptor, could probably be an effective compound in the treatment of insomnia. Synonyms: FILOREXANT; MK-6096; UNII-E6BTT8VA5Z; MK6096; MK 6096. Grade: 98%. CAS No. 1088991-73-4. Molecular formula: C24H25FN4O2. Mole weight: 420.48. | |
| Fimasartan | Fimasartan is an angiotensin II receptor blocker (ARB) with selectivity for angiotensin II receptor type 1. Fimasartan is approved in South Korea for the treatment of patients with hypertension and heart failure. Synonyms: 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamideBR-A657; BR A657; BRA657; BRA 657; Fimasartan. brand name: Kanarb. Grade: >95%. CAS No. 247257-48-3. Molecular formula: C27H31N7OS. Mole weight: 501.6. | |
| Fimasartan Impurity 1 | An impurity of Fimasartan. Fimasartan is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. Synonyms: 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide. Grade: > 95%. Molecular formula: C28H33N7OS. Mole weight: 515.69. | |
| Fimasartan Impurity 2 | An impurity of Fimasartan. Fimasartan is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. Synonyms: 2-butyl-1,?6-dihydro-N,?N,?4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)?-1H-tetrazol-5-yl]?[1,?1'-biphenyl]?-4-yl]?methyl]?-5-Pyrimidineethanethio?amide. Grade: > 95%. CAS No. 1361024-52-3. Molecular formula: C46H45N7OS. Mole weight: 743.98. | |
| Fimasartan Potassium Trihydrate | Fimasartan potassium trihydrate is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Synonyms: BR-A-657 Potassium Trihydrate; 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, potassium salt, hydrate (1:1:3). CAS No. 1020110-23-9. Molecular formula: C27H36KN7O4S. Mole weight: 593.78. | |
| FIN56 | FIN56 is a specific inducer of ferroptosis and causes the loss of GPX4 activity in cell lysates. Synonyms: FIN56; FIN-56; FIN 56. 2-N,7-N-dicyclohexyl-9-hydroxyiminofluorene-2,7-disulfonamide; s8254. CAS No. 1083162-61-1. Molecular formula: C25H31N3O5S2. Mole weight: 517.66. | |
| Finasteride acetate | Finasteride acetate is a specific inhibitor of 5α-reductase. Finasteride can be used in the treatment of men with benign prostatic, and through the assessment of the long-term safety and efficacy of finasteride hyperplasia (BPH) it was well tolerated, wit. Synonyms: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; acetic acid Finasteride (acetate). CAS No. 222989-99-3. Molecular formula: C25H40N2O4. Mole weight: 432.60. | |
| Finasteride Carboxylic Acid | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: 2-Methyl-N-[[(5α,17β)-3-oxo-4-azaandrost-1-en-17-yl]carbonyl]alanine. Grade: > 95%. CAS No. 116285-37-1. Molecular formula: C23H34N2O4. Mole weight: 402.54. | |
| Finasteride Carboxylic Acid-d6 | One of the isotope labelled impurities of Finasteride, which is an inhibitor of 5α-reductase. Synonyms: 2-Methyl-N-[[(5α,17β)-3-oxo-4-azaandrost-1-en-17-yl]carbonyl]alanine-d6. Molecular formula: C23H28N2O4D6. Mole weight: 408.57. | |
| Finasteride Dihydro Carboxylic Acid Methyl Ester | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: Methyl 3-oxo-4-aza-5α-androstane-17β-carboxylate; Methyl 4-aza-3-oxo-androstane-17β-carboxylate; 3-Oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester. Grade: 95%. CAS No. 73671-92-8. Molecular formula: C20H31NO3. Mole weight: 333.47. | |
| Finasteride EP Impurity B | An intermediate in the synthesis of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: Dutasteride Methyl ester Imp; Dutasteride Ester Impurity; 4-Azaandrost-1-ene-17-carboxylic acid, 3-oxo-, methyl ester, (5α,17β)-; 17β-(Methoxycarbonyl)-4-aza-5α-androst-1-en-3-one; 1H-Indeno[5,4-f]quinoline-7-carboxylic acid, 1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, methyl ester, [4aR-(4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)]-; 3-Oxo-4-aza-5α-androst-1-en-17β-carboxylic acid methyl ester; Methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate; Dutasteride methyl ester; Finasteride Methyl Ester Analog. Grade: >95%. CAS No. 103335-41-7. Molecular formula: C20H29NO3. Mole weight: 331.46. | |
| Finasteride Impurity | An intermediate in the synthesis of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: N-t-Butyl-3-Oxo-4-Aza-5-Androsten-17β-Carboxamide. Grade: > 95%. CAS No. 166896-74-8. Molecular formula: C23H36N2O2. Mole weight: 372.56. | |
| Finasteride Impurity A | The reduced product of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: Dihydro Finasteride; (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrostane-17-carboxamide. Grade: > 95%. CAS No. 98319-24-5. Molecular formula: C23H38N2O2. Mole weight: 374.57. | |
| Finasteride Impurity C | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: 5,6-Dehydro Finasteride. Grade: > 95%. CAS No. 1329611-51-9. Molecular formula: C23H34N2O2. Mole weight: 370.54. | |
| Finasteride Related Compound C | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: N-Des(1,1-dimethylethyl) N-Cyclohexyl Finasteride; (5α,17β)-N-Cyclohexyl-3-oxo-4-azaandrost-1-ene-17-carboxamide. Grade: > 95%. CAS No. 133216-45-2. Molecular formula: C25H38N2O2. Mole weight: 398.59. | |
| Finasteride Triene Impurity | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: 5,6,7,8-Dehydro Finasteride. Grade: > 95%. Molecular formula: C23H32N2O2. Mole weight: 368.52. | |
Our database is helping our users find suppliers everyday.
