BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
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(Trp4)-Octreotide
(Trp4)-Octreotide is an impurity of octreotide. Alternative Names: H-D-Phe-Cys-Phe-Trp-Lys-Thr-Cys-L-threoninol (Disulfide bridge: Cys2-Cys7); H-D-Phe-Cys-Phe-Trp-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7); D-phenylalanyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol (2->7)-disulfide. Grades: ≥95%. Molecular formula: C49H66N10O10S2. Mole weight: 1019.26.
(Trp63,Trp64)-C3a (63-77)
(Trp63,Trp64)-C3a (63-77). Alternative Names: H-TRP-TRP-GLY-LYS-LYS-TYR-ARG-ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG-OH. Grades: 95%. CAS No. 130154-64-2. Molecular formula: C86H134N26O18. Mole weight: 1820.15.
(Trp7,β-Ala8)-Neurokinin A (4-10)
(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent and selective NK-3 receptor antagonist demonstrated by antagonizing neurokinin B on the NK-3 receptor in the rat portal vein. Alternative Names: R486; L-α-Aspartyl-L-seryl-L-phenylalanyl-L-tryptophyl-β-alanyl-L-leucyl-L-methioninamide; L-Methioninamide, L-α-aspartyl-L-seryl-L-phenylalanyl-L-tryptophyl-β-alanyl-L-leucyl-; H-Asp-Ser-Phe-Trp-β-Ala-Leu-Met-NH2. Grades: ≥95%. CAS No. 132041-95-3. Molecular formula: C41H57N9O10S. Mole weight: 868.01.
(Tyr0)-C-Peptide (dog)
(Tyr0)-C-Peptide (dog) is a biomedical product used to mimic the action of endogenous C-peptide hormone in dogs. It can potentially study diabetes mellitus type 1 in canines by regulating blood sugar levels and promoting insulin synthesis. Alternative Names: Tyr-C-Peptide, dog; H-Tyr-Glu-Val-Glu-Asp-Leu-Gln-Val-Arg-Asp-Val-Glu-Leu-Ala-Gly-Ala-Pro-Gly-Glu-Gly-Gly-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ala-Leu-Gln-OH; L-tyrosyl-L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-arginyl-L-alpha-aspartyl-L-valyl-L-alpha-glutamyl-L-leucyl-L-alanyl-glycyl-L-alanyl-L-prolyl-glycyl-L-alpha-glutamyl-glycyl-glycyl-L-leucyl-L-glutaminyl-L-prolyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-glycyl-L-alanyl-L-leucyl-L-glutamine; L-Glutamine, L-tyrosyl-L-α-glutamyl-L-valyl-L-α-glutamyl-L-α-aspartyl-L-leucyl-L-glutaminyl-L-valyl-L-arginyl-L-α-aspartyl-L-valyl-L-α-glutamyl-L-leucyl-L-alanylglycyl-L-alanyl-L-prolylglycyl-L-α-glutamylglycylglycyl-L-leucyl-L-glutaminyl-L-prolyl-L-leucyl-L-alanyl-L-leucyl-L-α-glutamylglycyl-L-alanyl-L-leucyl-. Grades: 95%. CAS No. 101135-67-5. Molecular formula: C146H234N38O51. Mole weight: 3337.69.
(Tyr0)-C-Peptide (human)
(Tyr0)-C-Peptide (human) is a C-Peptide derivative used for radioimmunoassay. Alternative Names: H-Tyr-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH; L-tyrosyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-valyl-glycyl-L-glutaminyl-L-valyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-glycyl-L-alanyl-glycyl-L-seryl-L-leucyl-L-glutaminyl-L-prolyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-glycyl-L-seryl-L-leucyl-L-glutamine. Grades: ≥95% by HPLC. CAS No. 57327-90-9. Molecular formula: C138H220N36O50. Mole weight: 3183.43.
(Tyr0)-prepro-atrial natriuretic factor (104-123) (human). Alternative Names: (Tyr0)-kaliuretic peptide (human). CAS No. 309245-24-7. Molecular formula: C103H180N32O30. Mole weight: 2346.72.
[TYR11 ]-SOMATOSTATIN
[Tyr11]-Somatostatin is a neuroavtive peptide for proteomics research. Somatostatin is one of many neuroactive substances that influence retinal physiology. Alternative Names: 11-Tyr-somatostatin; 11-Tyrosine-somatostatin; Somatostatin, tyrosine(11)-; H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Tyr-Thr-Ser-Cys-OH. CAS No. 59481-27-5. Molecular formula: C76H104N18O20S2. Mole weight: 1653.88.
(Tyr1)-pTH (1-34) (human)
(Tyr1)-pTH (1-34) (human). Alternative Names: [Tyr1] Parathyroid Hormone (1-34), human; H-Tyr-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Grades: ≥95% by HPLC. CAS No. 213779-10-3. Molecular formula: C189H295N55O51S2. Mole weight: 4193.87.
[Tyr1]-Somatostatin
[Tyr1]-Somatostatin. Alternative Names: Tyr(1)-somatostain 14; 1-N-Tyr-somatostatin; Tyr-8-trp-somatostatin 14; Somatostatin, N-tyr(1)-. CAS No. 59481-23-1. Molecular formula: C82H108N18O20S2. Mole weight: 1729.97.
(Tyr27)-α-CGRP (27-37) (canine, mouse, rat)
(Tyr27)-α-CGRP (27-37) (canine, mouse, rat) is an empirically synthesized and selectively constructed peptide, epitomizing a conspicuous fragment of Calcitonin Gene-Related Peptide (CGRP). Alternative Names: [Tyr0] Calcitonin Gene Related Peptide (28-37), rat; H-Tyr-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2; L-tyrosyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-alpha-glutamyl-L-alanyl-L-phenylalaninamide. Grades: 95%. CAS No. 124501-79-7. Molecular formula: C54H79N13O17. Mole weight: 1182.28.
(Tyr34)-pTH (7-34) amide (bovine)
(Tyr34)-pTH (7-34) amide (bovine) is an inhibitor of the action of parathyroid hormone in vivo. Alternative Names: [Tyr34] Parathyroid Hormone (7-34), amide, bovine; H-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2; L-Phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-3-(7H-indol-3-yl)-L-alanyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-tyrosinamide. Grades: ≥95% by HPLC. CAS No. 86292-93-5. Molecular formula: C156H244N48O40S2. Mole weight: 3496.03.
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat) has been used for radioactive iodization. Alternative Names: (Tyr36)-Hypercalcemia of Malignancy Factor (1-36) (human, mouse, rat); H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Tyr-OH; (Tyr36)-pTHrP (1-36) (human, mouse, rat). Grades: ≥95%. CAS No. 213779-11-4. Molecular formula: C194H303N59O53. Mole weight: 4309.91.
[Tyr(So3H)63]-Hirudin Fragment 54-65
[Tyr(So3H)63]-Hirudin Fragment 54-65. Alternative Names: Hirudin (54-65) (sulfated); H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln-OH. Grades: 95%. CAS No. 109528-49-6. Molecular formula: C66H93N13O28S. Mole weight: 1548.58.
This is a mutation very close to the APP (A673V) β-secretase cleavage site. In contrast to the protective Icelandic mutation A2T, the recessive A2V mutation may increase the risk of Alzheimer's disease. APP A673V is associated with the early onset of AD dementia in homozygous individuals and has a protective effect in the heterozygous states. Alternative Names: H-Asp-Val-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. Molecular formula: C205H315N55O60S. Mole weight: 4542.16.
(Val2)-Amyloid β-Protein (1-6)
(Val2)-Amyloid β-Protein (1-6). Alternative Names: H-Asp-Val-Glu-Phe-Arg-His-OH; L-α-Aspartyl-L-valyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidine; H-DVEFRH-OH. Grades: ≥95%. CAS No. 727727-66-4. Molecular formula: C35H51N11O11. Mole weight: 801.86.
(Val34)-Amyloid β-Protein (1-40)
Cerebral amyloid angiopathy (CAA) is a common manifestation of Alzheimer's disease, characterized by amyloid-Aβ vascular deposition in >80% of cases. Mutations at sites 21-23 (such as the Dutch mutation E22Q) are primarily associated with CAA, although they present with significantly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant lies outside this hot spot, showing a similar bleeding phenotype, though less aggressive than the widely studied Dutch variant. Alternative Names: Amyloid β-Protein (1-40) L34V; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 1678415-83-2. Molecular formula: C193H293N53O58S. Mole weight: 4315.84.
(Val3,Pro8)-Oxytocin
(Val3,Pro8)-Oxytocin, the I3V/L8P variant of oxytocin binding to OT and AVP V1 receptors, is produced by the Saguinus genus of the Callitrichidae family of New World monkeys. When interacting with V1, (Pro8)-OT and oxytocin produce similar signal profiles and are equally effective against Gq and β-arrestin, while (Val3,Pro8)-OT is less effective against β-arrestin. Intranasal application of OT L8P and OT I3V/L8P enhanced parental behavior in rats. Alternative Names: H-Cys-Tyr-Val-Gln-Asn-Cys-Pro-Pro-Gly-NH2 (Disulfide bridge: Cys1-Cys6); (Val3,Pro8)-OT. CAS No. 2134138-89-7. Molecular formula: C41H60N12O12S2. Mole weight: 977.12.
(Val9)-Oxytocin
(Val9)-Oxytocin, a conopressin T analog, has increased affinity for V1a receptors and weak binding to V2 receptors. Oxytocin and (Val9)-Oxytocin exhibit the same properties, while native conopressin T (CYIQNCLRV-NH2) only binds to OT and V1a receptors. Alternative Names: G9V-OT; H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Val-NH2 (Disulfide bridge: Cys1-Cys6); conopressin T L7P/R8L. CAS No. 1021701-88-1. Molecular formula: C46H72N12O12S2. Mole weight: 1049.27.
(Z-Asp-Glu-Val-Asp)2-Rhodamine 110
(Z-Asp-Glu-Val-Asp)2-Rhodamine 110, a highly sensitive and photostable fluorogenic substrate, is used to determine intracellular caspase-3 activity. Fluorophore Rhodamine 110 (R110) can be detected at an emission wavelength of 535 nm using an excitation wavelength of 485 nm. As with (H-Asp-Glu-Val-Asp)2-Rhodamine 110, the fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy. Alternative Names: (Z-DEVD)2-Rhodamine 110; 4,4'-[9-(2-Carboxyphenyl)xanthylium-3,6-diyl]bis[N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-L-alpha-asparagine inner salt; (5S,8S,11S,14S,5'S,8'S,11'S,14'S)-14,14'-[(3-Oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diyl)dicarbamoyl]bis[8-(2-carboxyethyl)-5-(carboxymethyl)-11-isopropyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid]; (Z-DEVD)2-Rh 110. Grades: 95%. CAS No. 223538-61-2. Molecular formula: C72H78N10O27. Mole weight: 1515.46.