BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
N-Methyl-L-prolinol (CAS# 34381-71-0) is a reagent used in the synthesis of novel 4-hydroxytamoxifen analogs used as estrogen-related receptor γ (ERRγ) inverse agonists. Alternative Names: (S)-(-)-1-Methyl-2-pyrrolidinemethanol; (S)-(1-methylpyrrolidin-2-yl)methanol. CAS No. 34381-71-0. Molecular formula: C6H13NO. Mole weight: 115.17.
Nociceptin, a 17 amino acid neuropeptide involved in a variety of biological systems, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. Alternative Names: Orphanin FQ; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparagyl-L-glutamine; Nociceptin / orphanin FQ; Nociceptin (1-17); Orphanin FQ (rat, human, swine). Grades: ≥98% by HPLC. CAS No. 170713-75-4. Molecular formula: C79H129N27O22. Mole weight: 1809.04.
Nociceptin (1-13), amide
Nociceptin (1-13), amide is an effective ORL1 (OP4) receptor agonist. Alternative Names: Orphanin FQ (1-13) amide; N/OFQ-(1-13)-NH2; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide; Demethyl-AMPA; nociceptin / orphanin FQ-(1-13)-NH2. Grades: ≥95%. CAS No. 178064-02-3. Molecular formula: C61H100N22O15. Mole weight: 1381.59.
Nociceptin (1-13) amide TFA
Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. Alternative Names: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2.TFA; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide trifluoroacetic acid. Grades: 99%. Molecular formula: C63H101F3N22O17. Mole weight: 1495.61.
Nociceptin (1-7)
Nociceptin (1-7), the N-terminal fragment of Nociceptin, antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia. Alternative Names: L-Phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanine; 1-7-Orphanin FQ (pig); (2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoic acid. CAS No. 178249-42-8. Molecular formula: C31H41N7O9. Mole weight: 655.7.
Nociceptin (1-7) acetate
Nociceptin (1-7) acetate is a potent opioid receptor-like 1 (ORL1) receptor agonist, which in combination with nociceptin can reduce hyperalgesia and has antinociceptive activity. Alternative Names: L-Alanine, N-[N-[N-[N-[N-(N-L-phenylalanylglycyl)glycyl]-L-phenylalanyl]-L-threonyl]glycyl]-, acetate; L-Phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanine acetate; 1-7-Orphanin FQ (pig) acetate; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-OH.CH3CO2H. Grades: ≥95%. Molecular formula: C31H41N7O9. Mole weight: 655.70.
NODAGA-PEG-NT-XII
NODAGA-PEG-NT-XII is a neurotensin analog that can be used as a metal chelator for tumor imaging and drug delivery study. Mole weight: 1436.49.
Nogo-66 (1-40), a peptide fragment corresponding to residues 1-40 of Nogo-66, acts as a competitive antagonist at the Nogo-66 receptor (NgR), which blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Alternative Names: NEP1-40; Nogo Extracellular Peptide, 1-40. Grades: >95%. CAS No. 475221-20-6. Molecular formula: C206H324N56O65. Mole weight: 4625.16.
Noiiglutide
Noiiglutide is a glucagon-like peptide-1 (GLP-1) analog developed for the treatment of type 2 diabetes mellitus (T2DM). Alternative Names: SHR20004.
Nω-Nitro-D-arginine. Alternative Names: D-Arg(NO2)-OH; (R)-2-Amino-5-(3-Nitroguanidino)Pentanoic Acid. Grades: ≥ 98% (HPLC). CAS No. 66036-77-9. Molecular formula: C6H13N5O4. Mole weight: 219.20.
N-ω-Nitro-L-arginine p-nitroanilide hydrobromide
N-ω-Nitro-L-arginine p-nitroanilide hydrobromide. Alternative Names: H-Arg(NO2)-pNA HBr. CAS No. 29028-61-3. Molecular formula: C12H18BrN7O5. Mole weight: 420.22.
Nω,Nω'-Di-Z-L-arginine
Nω,Nω'-Di-Z-L-arginine. Alternative Names: L-Arg(Z)2-OH; (S,E)-2-amino-5-(2,3-bis(benzyloxycarbonyl)guanidino)pentanoic acid. Grades: ≥ 99% (HPLC). CAS No. 4125-79-5. Molecular formula: C22H26N4O6. Mole weight: 442.47.
Nonapeptide-1 acetate salt
It is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist. It is used as an additive in whitening or spot corrective products. Alternative Names: Melanostatine-5 acetate salt; H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2.CH3CO2H; L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide acetic acid. Grades: ≥98%. Molecular formula: C61H87N15O9S.C2H4O2. Mole weight: 1266.56.
Non-β-Amyloid component of Alzheimer's Disease (NAC) (8-18)
Non-β-Amyloid component of Alzheimer's Disease (NAC) (8-18) is the 8-18 amino acid residue of Non-β-Amyloid component of Alzheimer's Disease (NAC). NAC is the second component in the amyloid from brain tissue of patients affected with Alzheimer's disease. Alternative Names: Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala; Non-Aβ component of Alzheimer's Disease (NAC) (8-18); Non-Abeta component of Alzheimer's Disease (NAC) (8-18). Molecular formula: C41H73N11O14. Mole weight: 944.15.
Non-disulfide-bridged peptide 43
Non-disulfide-bridged peptide 43 is an antimicrobial peptide found in Opisthacanthus cayaporum (South American scorpion), and has antibacterial activity. Alternative Names: Trp-Ala-Thr-Leu-Ala-Lys-Gly-Ala-Leu-Lys-Leu-Ile-Pro-Thr-Ile-Ala-Asn-Ala-Phe-Ser-Ser-Lys-Ser; NDBP-43. Grades: ≥95%. Molecular formula: C111H182N28O30. Mole weight: 2388.84.
Non-disulfide-bridged peptide 5.5
Non-disulfide-bridged peptide 5.5 is an antimicrobial peptide found in Hadrurus gertschi (Scorpion, Hadrurus gertschi), and has antibacterial activity. Alternative Names: Ile-Phe-Ser-Ala-Ile-Ala-Gly-Leu-Leu-Ser-Asn-Leu-Leu; NDBP-5.5. Grades: ≥97%. Molecular formula: C63H106N14O17. Mole weight: 1331.62.
Non-disulfide-bridged peptide 5.6
Non-disulfide-bridged peptide 5.6 is an antimicrobial peptide found in Hadrurus gertschi (Scorpion, Hadrurus gertschi), and has antibacterial activity. Alternative Names: Phe-Ile-Phe-Asp-Leu-Leu-Lys-Lys-Leu-Val; NDBP-5.6. Grades: ≥97%. Molecular formula: C63H102N12O13. Mole weight: 1235.58.
Non-disulfide-bridged peptide 57
Non-disulfide-bridged peptide 57 is an antimicrobial peptide found in Opisthacanthus cayaporum (South American scorpion), and has antibacterial activity. Alternative Names: Leu-Ser-Ala-Ile-Trp-Ser-Gly-Ile-Lys-Ser; NDBP-57. Grades: ≥96%. Molecular formula: C49H80N12O14. Mole weight: 1061.25.
Non-disulfide-bridged peptide 58
Non-disulfide-bridged peptide 58 is an antimicrobial peptide found in Opisthacanthus cayaporum (South American scorpion), and has antibacterial activity. Alternative Names: Ile-Leu-Gly-Lys-Ile-Trp-Glu-Gly-Val-Lys-Ser; NDBP-58. Grades: ≥97%. Molecular formula: C58H96N14O15. Mole weight: 1229.49.
Non-specific lipid-transfer protein 1
Non-specific lipid-transfer protein 1 is an antimicrobial peptide found in Nigella sativa (Black cumin), and has antifungal activity. Alternative Names: LTP 1; Ile-Ser-Cys-Gln-Asp-Val-Lys-Gln-Ser-Leu-Ala-Pro-Cys-Leu-Pro-Tyr-Val-Thr-Gly-Arg-Ala-Pro-Lys-Pro-Ala; StnsLTP1. Grades: ≥96%.
Nonspecific lipid-transfer protein 1
Nonspecific lipid-transfer protein 1 is an antimicrobial peptide found in Vigna radiata var. radiata (mung bean), and has antibacterial and antifungal activity. Alternative Names: Met-Thr-Cys-Gly-Gln-Val-Gln-Gly-Asn-Leu-Ala-Gln-Cys-Ile-Gly-Phe-Leu-Gln-Lys-Gly-Gly. Grades: ≥98%.
Norleual
Norleual, an angiotensin IV analog, competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes. It is also an AT4 receptor antagonist, which disrupts LTP stabilization. Alternative Names: L-Norleucyl-L-tyrosyl-L-leucyl-ψ(ch2-nh)-L-histidyl-L-prolyl-L-phenylalanine. CAS No. 334994-34-2. Molecular formula: C41H58N8O7. Mole weight: 774.95.
(+)-Norrangiformic acid
(+)-Norrangiformic acid. Alternative Names: 1,2,3-Heptadecanetricarboxylic acid, threo- (8CI). CAS No. 26534-85-0. Molecular formula: C20H36O6. Mole weight: 372.5.
Nosiheptide precursor
Nosiheptide precursor is an antimicrobial peptide found in Streptomyces actuosus, and has antibacterial activity. Alternative Names: Cys-Thr-Thr-Cys-Glu-Cys-Cys-Cys-Ser-Cys-Ser. Grades: ≥90%.
NOTA-3PRGD2
NOTA-3PRGD2. Mole weight: 2500.84.
NOTA-Bis(t-butyl ester)
It is the PDC linker targeting moietie of peptide drug conjugates (PDCs). Alternative Names: 1,4-Bis(1,1-dimethylethyl)hexahydro-1H-1,4,7-triazonine-1,4,7-triacetate; NOTA-bis(tBu)ester; NOTA-bis(t-Bu ester); 1H-1,4,7-Triazonine-1,4,7-triacetic acid, hexahydro-, 1,4-bis(1,1-dimethylethyl) ester; 1,4-Bis(1,1-dimethylethyl) hexahydro-1H-1,4,7-triazonine-1,4,7-triacetate; 2-(4,7-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazonan-1-yl)acetic acid. Grades: ≥95%. CAS No. 1161415-28-6. Molecular formula: C20H37N3O6. Mole weight: 415.52.
NOTA-Ser-Asn-Asp-Arg-Pro-Pro-Asn-Ile-Leu-Gln-Gln-Arg is a peptide that was used in a study to image tumors. The peptide was used in a study of two HCC subcutaneous tumor models, HepG2 and SMMC-7721.
NOTA-TATE
NOTA-TATE is a peptide conjugated with covalently bonded DOTA bifunctional chelator. NOTA-TATE can be used in PET scan for tumor imaging. Alternative Names: NOTA-(D-Phe)-Cys-Tyr-(D-Trp)-Lys-Thr-Cys-Thr (Disulfide bond Cys2/Cys7); NOTA-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr (Disulfide bond Cys2/Cys7). Molecular formula: C62H84N12O17S2. Mole weight: 1333.54.
Novokinin acetate
Novokinin acetate is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction. Alternative Names: H-Arg-Pro-Leu-Lys-Pro-Trp-OH.CH3CO2H; L-arginyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-tryptophan acetic acid; Acetic acid, compd. with (L-arginyl-yl-L-leucyl-yl-L-lysyl-yl-L-prolyl-yl-L-prolyl-yl)-L-Tryptophan (1:1). Grades: ≥95%. CAS No. 2803405-27-6. Molecular formula: C41H65N11O9. Mole weight: 856.02.