BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Azotochelin | Azotochelin is produced by the strain of Azotobacter vinelandii. Alternative Names: N2,N6-Bis(2,3-dihydroxybenzoyl)-L-lysine; L-Lysine, N2,N6-bis(2,3-dihydroxybenzoyl). CAS No. 23369-85-9. Molecular formula: C20H22N2O8. Mole weight: 418.40. |  |
| Azoxybacilin | Azoxybacilin is produced by the strain of Bacillus cereus NR2991. It can inhibit the sulfur fixation reaction in methionine biosynthesis and has strong anti-filamentous fungal activity: The IC80 of Aspergillus fumigata and Trichoderma was 0.71 ~ 1.3 μg/mL and 0.03 ~ 0.24 μg/mL, respectively. It had only moderate activity to yeast-based fungi, and the IC80 of Candida albicans was 4.2 ~ 5.8 μg/mL. Alternative Names: (2s)-2-amino-4-[(z)-methyl-nno-azoxy]butanoic acid; Butanoic acid, 2-amino-4-[(1Z)-methyl-NNO-azoxy]-, (2S)-. CAS No. 157998-96-4. Molecular formula: C5H11N3O3. Mole weight: 161.16. | |
| B-5354a | B-5354a is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 21 μmol/L. Molecular formula: C19H29NO3. Mole weight: 319.44. | |
| B-5354b | B-5354b is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 58 μmol/L. Molecular formula: C21H31NO3. Mole weight: 345.47. | |
| B-5354c | B-5354c is a Sphingosine kinase (SPHK) inhibitor produced by SANK 71896. It has the activity of inhibiting SPHK with IC50 of 38 μmol/L. Molecular formula: C21H33NO3. Mole weight: 347.49. | |
| B-90063 | B-90063 is an endothelin transferase (ECE) inhibitor produced by Blastobacter sp. SANK 71894. It has a strong inhibitory effect on human and rat ECE, with IC50 of 1.0 and 3.2 μmol/L, respectively. Molecular formula: C28H30N4O6S2. Mole weight: 582.69. | |
| Bacampicillin | It is produced by the strain of 6-APA and Ampicillin. Bacampicillin may increase the anticoagulant activities of Acenocoumarol as a prodrug of ampicillin. Uses: A penicillin antibiotic. Alternative Names: Bacampicilline; 1'-Ethoxycarbonyloxyethyl-(6-D-alpha-aminophenylacetamido)penicillanate. Grades: ≥95%. CAS No. 50972-17-3. Molecular formula: C21H27N3O7S. Mole weight: 465.52. | |
| Bacimethrin | Bacimethrin is produced by the strain of Bacillus megatheriumy and Streptomyces albus. It has anti-fungal and gram-positive bacteria, negative bacteria activity, and vitamin B1 and B6 can reduce its activity. Alternative Names: 4-amino-2-methoxy-5-pyrimidinemethanol; 5-pyrimidinemethanol, 4-amino-2-methoxy-. Grades: ≥98%. CAS No. 3690-12-8. Molecular formula: C6H9N3O2. Mole weight: 155.15. | |
| Baciphelacin | Baciphelacin is produced by the strain of Bacillus thiaminolyticus. It is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells. Alternative Names: baciphelacin; Antibiotic B 17; 5-Amino-N-[1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-2-methyl-3,4-dihydroxyheptanamide. CAS No. 57765-71-6. Molecular formula: C22H34N2O6. Mole weight: 422.52. | |
| Bacithrocin A | Bacithrocin A is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively. Molecular formula: C20H31N5O3. Mole weight: 389.49. | |
| Bacithrocin B | Bacithrocin B is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively. Molecular formula: C19H29N5O3. Mole weight: 375.46. | |
| Bacithrocin C | Bacithrocin C is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively. Molecular formula: C18H27N5O3. Mole weight: 361.44. | |
| Bacithrocin D | Bacithrocin D is produced by the strain of Bacillus laterosporus Laubach NR 2988. The ED50 of the four components A, B, C and D were 48, 84, 80, 124X10-6 mol/L, and the reference antipain was 13X10-6 mol/L, respectively. Alternative Names: SCHEMBL21360283. CAS No. 96440-64-1. Molecular formula: C17H25N5O3. Mole weight: 347.41. | |
| Bacitracin F | Bacitracin F is a major Bacitracin analog, a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI). It is isolated from Bacillus. Alternative Names: Bacitracin EP Impurity E; 4,10-anhydro[N-[[2-[(2S)-2-methyl-1-oxobutyl]-1,3-thiazol-4-yl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-Llysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine]. Grades: >95%. CAS No. 22601-63-4. Molecular formula: C66H98N16O17S. Mole weight: 1419.68. | |
| Bacitracin F, copper deriv. | Bacitracin is a cyclic peptide complex isolated from Bacillus licheniformis. Bacitracin has anti-Gram-positive bacteria activity and can be used clinically as a topical treatment for skin infections. Grades: >95% by HPLC. CAS No. 85800-09-5. Molecular formula: C66H101CuN17O16S. Mole weight: 1484.23. | |
| Bacteriochlorophylls b | Bacteriochlorophylls b is produced by the strain of Chlorobiea and Rhodospirillinea. It has a structural skeleton similar to chlorophyll of higher plants. Molecular formula: C55H72MgN4O6. Mole weight: 909.49. | |
| Bactobolin | Bactobolin is produced by the strain of Pseudomonas yoshitomensis. It has the activity of anti-gram-positive bacteria and negative bacteria, and can be used to inhibit experimental tumor. Alternative Names: (-)-Bactobolin; Antibiotic BN 183B; Propanamide, 2-amino-N-(3-(dichloromethyl)-3,4,4a,5,6,7-hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2-benzopyran-4-yl)-, (3S-(3alpha,4alpha(R*),4abeta,5beta,6alpha))-. CAS No. 72615-20-4. Molecular formula: C14H20Cl2N2O6. Mole weight: 383.22. | |
| Badione A | It is produced by the strain of Xerocomus badius. Badione A can form a stable salt with potassium ions. Molecular formula: C36H18O17. Mole weight: 722.52. | |
| Badione B | It is produced by the strain of Xerocomus badius. Badione B can form a stable salt with potassium ions. Molecular formula: C36H18O18. Mole weight: 738.52. | |
| Bafilomycin | Bafilomycins are a family of macrolide antibiotics isolated from Streptomycetes sp. They exhibits antitumor, antiparasitic, immunosuppressant and antifungal activity. CAS No. 151499-39-7. | |
| Bafilomycin B1 | Bafilomycin B1 is produced by the strain of Streptomyces griseus ssp. sulphurus TU 1022 and Str. griseus TU 2437. A member of a potent family of macrocyclic lactones; broadly active against bacteria, fungi, insects, nematodes and protozoans; a potential agent for treating osteoporosis. It can inhibit the growth of gram-positive bacteria, negative bacteria, fungi, yeast and protozoa, and has the effects of insect killing, nematode killing and immunosuppression. Alternative Names: Setamycin. Grades: >95% by HPLC. CAS No. 88899-56-3. Molecular formula: C44H65NO13. Mole weight: 815.98. | |
| Bafilomycin C1 | Bafilomycin C1 is a macrolide compound found in Streptomyces and an inhibitor of V-ATPase protein. It has a wide range of activities against bacteria, fungi, insects, and nematodes. It is a potential drug for the treatment of osteoporosis. Alternative Names: L-681,110A1. Grades: >95% by HPLC. CAS No. 88979-61-7. Molecular formula: C39H60O12. Mole weight: 720.88. | |
| Bagougeramine A | Bagougeramine A is produced by the strain of Bacillus circulans TB-2125. Both of A and B have activities against gram-positive bacteria and negative bacteria, and B has higher activity than A, except for Pseudomonas aeruginosa A3. Alternative Names: beta-D-Glucopyranuronamide, 4-((3-((aminoiminomethyl)amino)-N-(N-methylglycyl)-D-alanyl)amino)-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,4-dideoxy-. CAS No. 104840-35-9. Molecular formula: C17H28N10O7. Mole weight: 484.47. | |
| Bagougeramine B | Bagougeramine B is produced by the strain of Bacillus circulans TB-2125. Both of A and B have activities against gram-positive bacteria and negative bacteria, and B has higher activity than A, except for Pseudomonas aeruginosa A3. Alternative Names: beta-D-Glucopyranuronamide, N-(3-((4-aminobutyl)amino)propyl)-4-((3-((aminoiminomethyl)amino)-N-(N-methylglycyl)-D-alanyl)amino)-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,4-dideoxy-. CAS No. 104840-34-8. Molecular formula: C24H44N12O7. Mole weight: 612.68. | |
| Bagremycin A | It is produced by the strain of Streptomyces sp. Tu 4128. Bagremycin A has weak activity against gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans. Alternative Names: CHEMBL4125959. Molecular formula: C15H13NO3. Mole weight: 255.27. | |
| Bagremycin B | It is produced by the strain of Streptomyces sp. Tu 4128. Bagremycin B has weaker activity against gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans than A. Alternative Names: CHEMBL4129272. Molecular formula: C17H15NO4. Mole weight: 297.30. | |
| Balanol | It is produced by the strain of Streptomyces sp. Tu 4128. Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA). It is an important target in oncology. Alternative Names: 4-(2-Carboxy-6-hydroxybenzoyl)-3,5-dihydroxybenzoic Acid (3R,4R)-Hexahydro-3-[(4-hydroxybenzoyl)amino]-1H-azepin-4-yl Ester; (3R-trans)-Balanol; (-)-Balanol; Azepinostatin; Ophiocordin. Grades: >95%. CAS No. 63590-19-2. Molecular formula: C28H26N2O10. Mole weight: 550.53. | |
| Baloxavir | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Alternative Names: Baloxavir acid; BXA; Xofluza; S-033447. Grades: ≥98%. CAS No. 1985605-59-1. Molecular formula: C24H19F2N3O4S. Mole weight: 483.49. | |
| Bamicetin | Bamicetin is produced by the strain of Streptomyces licatus. Mainly resistant to gram-positive bacteria and Mycobacteria, acute toxicity is lower than Amicetin (dog, subcutaneous). Alternative Names: Benzamide, 4-((2-amino-3-hydroxy-2-methyl-1-oxopropyl)amino)-N-(1,2-dihydro-2-oxo-1-(2,3,6-trideoxy-4-O-(4,6-dideoxy-4-(methylamino)-alpha-D-glucopyranosyl)-beta-D-erythro-hexopyranosyl)-4-pyrimidinyl)-, (S)-. CAS No. 43043-14-7. Molecular formula: C28H40N6O9. Mole weight: 604.65. | |
| Baohuoside VII | Baohuoside VII is a compound of the flavonoid class found in the herbs of Epimedium brevicornum Maxim. Alternative Names: 3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one. Grades: >98%. CAS No. 119730-89-1. Molecular formula: C33H40O15. Mole weight: 676.668. | |
| BAR502 | BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively). Alternative Names: BAR-502; BAR 502; BAR502; (5S,8S,9R,10S,13R,14S,17R)-6-ethyl-17-(4-hydroxybutan-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol. CAS No. 1612191-86-2. Molecular formula: C25H44O3. Mole weight: 392.62. | |
| Barbamide | Barbamide is produced by the strain of Lyn-gbya majiuscula. It has the activity of killing mollusks. Alternative Names: CHEBI:80028. Molecular formula: C20H23Cl3N2O2S. Mole weight: 461.83. | |
| Barminomycin I | Barminomycin I is produced by the strain of Actinomadura roseoviolacea and A. carminata. I and II showed strong inhibition of P388 leukemia cells with IC50 of about 0.00001 and 0.00002 g/mL, respectively (reference Doxorubicin of 0.013 g/mL). Alternative Names: SN-07 Chromophore; 5,12-Naphthacenedione,8-acetyl-10-[[4,6a,7,8,10,10a-hexahydro-2-(2-hydroxypropyl)-4,10-dimethylpyrano[3,4-d]-1,3,6-dioxazocin-8-yl]oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-(9CI). CAS No. 108147-17-7. Molecular formula: C33H37NO12. Mole weight: 639.64. | |
| Barminomycin II | Barminomycin II is produced by the strain of Actinomadura roseoviolacea and A. carminata. I and II showed strong inhibition of P388 leukemia cells with IC50 of about 0.00001 and 0.00002 g/mL, respectively (reference Doxorubicin of 0.013 g/mL). Alternative Names: 8-Acetyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-((octahydro-5-hydroxy-2-(2-hydroxypropyl)-4,10-dimethylpyrano(3,4-d)-1,3,6-dioxazocin-8-yl)oxy)-5,12-naphthacenedione; 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-((octahydro-5-hydroxy-2-(2-hydroxypropyl)-4,10-dimethylpyrano(3,4-d)-1,3,6-dioxazocin-8-yl)oxy)-. CAS No. 108089-33-4. Molecular formula: C33H39NO13. Mole weight: 657.66. | |
| Basidalin | Basidalin is produced by the strain of Leucoagaricus naucina NZ157. It has the ability of anti-gram-positive bacteria, negative bacteria and inhibition of mouse leukemia L-1210 cell. Alternative Names: (Z)-4-Amino-5-(formylmethylene)-2(5H)-furanone; (Z)-(3-Amino-5-oxo-2(5H)-furanylidene)acetaldehyde; Acetaldehyde, (3-amino-5-oxo-2(5H)-furanylidene)-. Molecular formula: C6H5NO3. Mole weight: 139.11. | |
| Bassianolide | It is a cyclooctadepsipeptide antibiotic isolated from the entomopathogenic fungi. It is one of the active components of beauveria bassiana biocontrol products. It has insecticidal properties. Alternative Names: (-)-Bassianolide; NSC 321804; BASS; cyclo[N(Me)Leu-D-OVal-N(Me)Leu-D-OVal-N(Me)Leu-D-OVal-N(Me)Leu-D-OVal]; cyclo[N-methyl-L-leucyl-N-oxa-D-valyl-N-methyl-L-leucyl-N-oxa-D-valyl-N-methyl-L-leucyl-N-oxa-D-valyl-N-methyl-L-leucyl-N-oxa-D-valyl]. Grades: >95% by HPLC. CAS No. 64763-82-2. Molecular formula: C48H84N4O12. Mole weight: 909.20. | |
| Baumycin A1 | Baumycin A1 is produced by the strain of Streptomyces sp. ME 130-A4. Alternative Names: 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-4-O-(3-hydroxy-1-(2-hydroxy-1-methylethoxy)butyl)-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-. CAS No. 64314-28-9. Molecular formula: C34H43NO13. Mole weight: 673.70. | |
| Baumycin B1 | Baumycin B1 is produced by the strain of Streptomyces sp. ME 130-A4. Alternative Names: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-acetyl-10-((3-amino-4-O-(1-(1-carboxyethoxy)-3-hydroxybutyl)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-; 3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-4-o-[1-(1-carboxyethoxy)-3-hydroxybutyl]-2,3,6-trideoxyhexopyranoside. CAS No. 64253-72-1. Molecular formula: C34H41NO14. Mole weight: 687.69. | |
| Baumycin C1 | Baumycin C1, an impurity of Daunorubicin and Doxorubicin, is an anthracycline antibiotic isolated from Streptomyces coeruleorubidus. Baumycin C1 shows antitumor activity. Alternative Names: N-((2S,3S,4S,6R)-6-(((1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)-3-hydroxy-2-methyltetrahydro-2H-pyran-4-yl)formamide; N-Formyldaunorubicin; NSC 227012; 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(formylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-, (8S-cis)-; (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[(3-(formylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-5,12-naphthacenedione. Grades: ≥95%. CAS No. 63084-42-4. Molecular formula: C28H29NO11. Mole weight: 555.53. | |
| Bayogenin 3-O-β-D-glucopyranoside | Bayogenin 3-O-β-D-glucopyranoside is a triterpenoid saponin isolated from the aerial parts of Polygala japonica Houtt. Alternative Names: 2beta,23-Dihydroxy-3beta-(beta-D-glucopyranosyloxy)oleana-12-ene-28-oic acid. Grades: >98%. CAS No. 104513-86-2. Molecular formula: C36H58O10. Mole weight: 650.85. | |
| BE-10988 | BE-10988 is a topoisomerase-II inhibitor produced by Str. sp. BA 10988. It has the activity of inhibiting P388 murine leukemia cells. It inhibits P388 (P388S), vincristine-doxorubicin-resistant P388 (P388/VCR) and doxorubicin-resistant P388 (P388/MDR) cells with IC50 (μmol/L) of 0.5, 0.4, 2.0, respectively. CAS No. 135261-89-1. Molecular formula: C13H10N4O3S. Mole weight: 302.31. | |
| BE-12406 A | BE-12406 A is an antitumor antibiotic produced by Streptomyces rutrersensis subsp. castelarensis. It has the activity of inhibiting murine P388 leukemia cells (IC50 is 0.8 μmol/L), and has the same activity against vincristine-doxorubicin resistant strains (P388/VCR) (IC50 is 0.2 μmol/L). It can inhibit the growth of S480 ascites carcinoma in mice. Alternative Names: BE 12406A; 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 12-((6-deoxy-alpha-L-mannopyranosyl)oxy)-1-hydroxy-10-methoxy-8-methyl-. CAS No. 132417-96-0. Molecular formula: C25H24O9. Mole weight: 468.45. | |
| BE-12406 B | BE-12406 B is an antitumor antibiotic produced by Streptomyces rutrersensis subsp. castelarensis. It has the activity of inhibiting murine P388 leukemia cells (IC50 is 7 μmol/L), and has the same activity against vincristine-doxorubicin resistant strains (P388/VCR) (IC50 is 7 μmol/L). It can inhibit the growth of S480 ascites carcinoma in mice. Alternative Names: 12-((6-Deoxyhexopyranosyl)oxy)-1,10-dihydroxy-8-methyl-6H-benzo(d)naphtho(1,2-b)pyran-6-one. CAS No. 132417-97-1. Molecular formula: C24H22O9. Mole weight: 454.43. | |
| BE 14106 | BE 14106 is produced by the strain of Streptomyces sp. It has weak anti-Pseudomonas aeruginosa activity and inhibition of mixed lymphocyte reaction (MLR) activity. Alternative Names: BE-14106; GT-32A; 9,10-Dihydroxy-7,15-dimethyl-20-(2-hexenyl)azacycloeicosa-3,5,7,11,13,15,17-heptaen-2-one. CAS No. 140212-86-8. Molecular formula: C27H37NO3. Mole weight: 423.59. | |
| BE-18257A | BE-18257 A is an endothelin binding inhibitor produced by Streptomyces misakiensis. Alternative Names: Cyclo(valyl-leucyl-tryptophyl-glutamyl-alanyl); Cyclo(L-alanyl-D-valyl-L-leucyl-D-tryptophyl-D-alpha-glutamyl). CAS No. 136553-73-6. Molecular formula: C30H42N6O7. Mole weight: 598.69. | |
| BE-18257B | BE-18257 B is an endothelin binding inhibitor produced by Streptomyces misakiensis. Alternative Names: Cyclo(L-alanyl-D-alloisoleucyl-L-leucyl-D-tryptophyl-D-alpha-glutamyl); LS-55815. Molecular formula: C31H44N6O7. Mole weight: 612.72. | |
| BE-19412A | BE-19412A is an antitumor antibiotic extracted from the culture medium of Streptomyces sp. A19412. It is toxic to mouse and human tumor cells such as P388, Ehrlich, DLD-1, PC-13, MKN-45 and Colon 26, with IC50 of 0.9-5.4 μg/mL, and can prolong the survival time of CDF1 mice with Ehrlich cancer. Alternative Names: LS-94141. CAS No. 173774-90-8. Molecular formula: C28H22ClNO8. Mole weight: 535.93. | |
| BE-19412B | BE-19412B is an antitumor antibiotic extracted from the culture medium of Streptomyces sp. A19412. It is toxic to mouse and human tumor cells such as P388, Ehrlich, DLD-1, PC-13, MKN-45 and Colon 26, with IC50 of 0.9-5.4 μg/mL, and can prolong the survival time of CDF1 mice with Ehrlich cancer. Alternative Names: LS-94140. CAS No. 173774-91-9. Molecular formula: C30H26ClNO8. Mole weight: 563.98. | |
| BE-23372M | BE-23372M is a protein tyrosine kinase inhibitor produced by Rhizoctonia solani. It has strong inhibition of epidermal growth factor (EGF) receptor kinase activity. Alternative Names: (3E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)furan-2(3H)-one. CAS No. 145588-13-2. Molecular formula: C17H12O6. Mole weight: 312.27. | |
| BE-29602 | BE-29602 is a papulacandin antibiotic produced by Fusarium sp. F296O2. It has activity against Candida, Saccharomyces cerevisiae and other fungi, with an MIC of 0.20-0.7 μg/mL. It is cytotoxic and has an IC50 of 21 μg/mL to P388 murine leukemia cells. Molecular formula: C45H62O16. Mole weight: 858.96. | |
| BE-31405 | BE-31405 is an antifungal antibiotic produced by Penicillum minioluteum F31405. It has activity against pathogenic fungi such as Candida albicans and Cryptococcus neoformans (MIC 3.13-6.25 μg/mL), and has no cytotoxicity to mammalian cells (such as P388 murine leukemia, etc.). Molecular formula: C28H36O10. Mole weight: 532.58. | |
| BE-32030A | BE-32030A is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells. Alternative Names: BE-32030 A. CAS No. 161589-09-9. Molecular formula: C39H61N5O10. Mole weight: 759.93. | |
| BE-32030B | BE-32030B is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells. Alternative Names: Lysine, N(sup 2)-((4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-oxazolyl)carbonyl)-N(sup 6)-hydroxy-N(sup 6)-(1-oxotetradecyl)-, 3-((hexahydro-1-hydroxy-2-oxo-1H-azepin-3-yl)amino)-1-methyl-3-oxopropyl ester; BE-32030 B. CAS No. 161589-10-2. Molecular formula: C41H65N5O10. Mole weight: 787.98. | |
| BE-32030C | BE-32030C is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells. Alternative Names: BE-32030 C. CAS No. 161589-11-3. Molecular formula: C43H67N5O10. Mole weight: 814.02. | |
| BE-32030D | BE-32030D is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells. Alternative Names: BE-32030 D. CAS No. 161589-12-4. Molecular formula: C39H61N5O11. Mole weight: 775.93. | |
| BE-32030E | BE-32030E is an antitumor antibiotic produced by Nocardia sp. A32030. It has inhibitory effect on the growth of P388, DLD-h PC-13 and MKN-45 tumor cells. Alternative Names: BE-32030 E. CAS No. 161589-13-5. Molecular formula: C41H63N5O10. Mole weight: 785.97. | |
| BE-40644 | BE-40644 is an inhibitor of human Thioredoxin system produced by Actinoplanes sp. A40644. It can inhibit the growth of several tumor cells. Alternative Names: 4,4,6aalpha,12bbeta-Tetramethyl-9-(hydroxymethyl)-1,3,4,4aalpha,5,6,6a,12,12aalpha,12b-decahydro-2H-benzo[a]xanthene-8,11-dione. CAS No. 172923-88-5. Molecular formula: C22H30O4. Mole weight: 358.47. | |
| BE-40665D | BE-40665D is an antibiotic produced by Actinoplanes sp. A4O665. It has moderate anti-gram-positive bacteria activity and has no effect on gram-positive bacteria. CAS No. 183241-67-0. Molecular formula: C22H21BrO7. Mole weight: 477.30. | |
| BE-43472B | BE-43472B is a bisanthraquinone antibiotic isolated from a streptomycete strain. It has antibacterial activity against MSSA, MRSA, TRSA and VRE. Alternative Names: (8S,9S,9aR,18aS,20R)-8,9-Dihydro-4,6,8,16-tetrahydroxy-8,14,20-trimethyl-18a,9-(epoxymethano)-18aH-dianthra[1,2-b:4'a,10'-d]furan-5,12,17(7H)-trione; 18a,9-(Epoxymethano)-18aH-dianthra[1,2-b:4'a,10'-d]furan-5,12,17(7H)-trione, 8,9-dihydro-4,6,8,16-tetrahydroxy-8,14,20-trimethyl-, (8S,9S,9aR,18aS,20R)-. CAS No. 180027-59-2. Molecular formula: C32H24O9. Mole weight: 552.53. | |
| BE-52440A | BE-52400A is a cytotoxicity produced by Streptomyces sp. A52400. It has anti-proliferative effect on mouse tumor cell lines such as P388 leukemia and colon 26 colon and human tumor cell lines such as DLD1 (colon), PC-13 (lung), MKN-45 (stomach), etc., with IC50 of 6.1, 2.1, 0.47, 3.9, 0.88 μg/mL. CAS No. 195051-22-0. Molecular formula: C34H34O14S. Mole weight: 698.69. | |
| BE-52440B | BE-52400B is a cytotoxicity produced by Streptomyces sp. A52400. It has anti-proliferative effect on mouse tumor cell lines such as P388 leukemia and colon 26 colon and human tumor cell lines such as DLD1 (colon), PC-13 (lung), MKN-45 (stomach), etc., with IC50 of 1.1, 3.4, 0.69, 2.6, 2.9 μg/mL. CAS No. 195051-23-1. Molecular formula: C33H34O13S. Mole weight: 670.68. | |
| BE-54238A | BE-54238A is a cytotoxic agent produced by Streptomyces sp. A54238. It has anti-proliferative effects on tumor cells such as P388, DLD4, PC-13, MKN-45, colon 26, etc., with IC50 of (μg/mL) 9.1, 3.5, 11.3, 8.1, 8.6. Alternative Names: BE-54238 A; (-)-Be-54238a; 2-(5-Hydroxy-11-(1-hydroxyethyl)-4-methyl-6-oxo-1,4,6,9,10,11-hexahydro-2H-benzo(cd)pyrano(3,4-g)pyrrolo(1,2-a)indol-2-yl)acetic acid. CAS No. 205433-26-7. Molecular formula: C22H23NO6. Mole weight: 397.42. | |
| BE-54238B | BE-54238B is a cytotoxic agent produced by Streptomyces sp. A54238. It has anti-proliferative effects on tumor cells such as P388, DLD4, PC-13, MKN-45, colon 26, etc., with IC50 of (μg/mL) 58.2, 10.1, 53.2, 45.6, 20.5. Alternative Names: BE-54238 B. CAS No. 205433-27-8. Molecular formula: C22H21NO6. Mole weight: 395.40. | |
| Beauveriolide I | Beauveriolide I is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Alternative Names: CHEMBL516093; SCHEMBL15474166. CAS No. 154491-55-1. Molecular formula: C27H41N3O5. Mole weight: 487.63. | |
| Beauveriolide III | Beauveriolide III is produced by the strain of Beauveria sp. FO-6979. The effect of I and III can inhibit the formation of Lipid droplet. 10μmol/L can reduce the number and size of the cytolipid droplet in the macrophage but it is not cytotoxic to the macrophages. Alternative Names: CHEMBL409855; SCHEMBL16174055. CAS No. 221111-70-2. Molecular formula: C27H41N3O5. Mole weight: 487.63. | |
| Belactosin A | Belactosin A is produced by the strain of Streptomyces sp. No antibacterial activity. A inhibits the IC50 of HeLa S3 cells is 51μmol/L. Alternative Names: (alphaS,1S)-alpha-(L-Alanylamino)-2beta-[[[(2R)-3alpha-[(S)-sec-butyl]-4-oxooxetane-2beta-yl]carbonyl]amino]cyclopropane-1beta-propionic acid. Molecular formula: C17H27N3O6. Mole weight: 369.41. | |
| Belactosin C | Belactosin C is produced by the strain of Streptomyces sp. No antibacterial activity. C inhibits the IC50 of HeLa S3 cells is 200μmol/L. Alternative Names: SCHEMBL3448978; CHEMBL1783833. CAS No. 189871-55-4. Molecular formula: C16H27N3O6. Mole weight: 357.40. | |
| Benadrostin | Benadrostin is produced by the strain of Streptomyces flavovirens MH499-O'Flc. Poly-(adp-Ribose) synthetase was inhibited with IC50 of 35μmol/L. Alternative Names: 8-Hydroxy-2H-1,3-benzoxazine-2,4(3H)-dione; 2H-1,3-Benzoxazine-2,4(3H)-dione, 8-hydroxy-. CAS No. 117241-60-8. Molecular formula: C8H5NO4. Mole weight: 179.13. | |
| Benanomicin A | Benanomicin A is produced by the strain of Actinomadura sp. MH193-16F4. A and B have anti-candida, Cryptococcus neoforme, Saccharomyces cerevisiae and other fungal activities, while A has stronger activity. Xylose benamycin A and B showed similar or slightly stronger activity against candida, yeast and Cryptococcus, but decreased activity against aspergillus. The antifungal activity of 2-demethylbenamycin was similar to that of xylose Benamycin A. The synthesized 7-methoxybenamycin had little antifungal activity, but showed inhibitory activity of glucosinolase (EC 3.2.1.20) with IC50 of 60μg/mL. Alternative Names: Benanomicin A;116249-65-1;(2R)-2-[[(5S,6S)-5-[(2S,3R,4S,5S,6R)-3,5-dihydroxy-6-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxo-5,6-dihydrobenzo[a]tetracene-2-carbonyl]amino]propanoic acid;D-Alanine, N-((5-((6-deoxy-3-O-beta-D-xylopyranosyl-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-meth. CAS No. 116249-65-1. Molecular formula: C39H41NO19. Mole weight: 827.74. | |
| Benanomicin B | Benanomicin B is produced by the strain of Actinomadura sp. MH193-16F4. A and B have anti-candida, Cryptococcus neoforme, Saccharomyces cerevisiae and other fungal activities, while A has stronger activity. Xylose benamycin A and B showed similar or slightly stronger activity against candida, yeast and Cryptococcus, but decreased activity against aspergillus. The antifungal activity of 2-demethylbenamycin was similar to that of xylose Benamycin A. The synthesized 7-methoxybenamycin had little antifungal activity, but showed inhibitory activity of glucosinolase (EC 3.2.1.20) with IC50 of 60μg/mL. Alternative Names: Pradimicin C; D-Alanine, N-((5-((4-amino-4,6-dideoxy-3-O-beta-D-xylopyranosyl-beta-D-galactopyranosyl)oxy)-5,6,8,13-tetrahydro-1,6,9,14-tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo(a)naphthacen-2-yl)carbonyl)-. CAS No. 116249-66-2. Molecular formula: C39H42N2O18. Mole weight: 826.75. | |
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