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Seneciphyllinine
Seneciphyllinine is an alkaloid isolated from Gynura segetum. Alternative Names: 12-Acetylseneciphylline; Acetylseneciphylline; O-acetylseneciphylline; Seneciphylline acetate. Grades: 60.0%. CAS No. 90341-45-0. Molecular formula: C20H25NO6. Mole weight: 375.421.
Senfolomycin A
It is produced by the strain of Str. ochrosporus NRRL 3146. It has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, streptomycin, neomycin, macrolide antibiotics. It also has weaker effect of anti-Gram-negative bacteria. Alternative Names: Paulomycin E; 1-Cyclohexene-1-carboxylic acid, 5-[6-O-acetyl-3-O-(4-C-acetyl-2,6-dideoxy-3-O-methyl-a-L-xylo-hexopyranosyl)-4-O-[(2Z)-2-isothiocyanato-1-oxo-2-butenyl]-b-D-allopyranosyl]-2-amino-5-hydroxy-3,6-dioxo-, (5S)-; Antibiotic LL RA 6950BA. CAS No. 11017-36-0. Molecular formula: C29H36N2O16S. Mole weight: 700.66.
Senfolomycin B
It is produced by the strain of Str. ochrosporus NRRL 3146. It has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, streptomycin, neomycin, macrolide antibiotics. It also has weaker effect of anti-Gram-negative bacteria. Alternative Names: Paulomycin F; 1-Cyclohexene-1-carboxylic acid, 5-[6-O-acetyl-3-O-[2,6-dideoxy-4-C-(1-hydroxyethyl)-3-O-methyl-α-L-xylo-hexopyranosyl]-4-O-[(2Z)-2-isothiocyanato-1-oxo-2-buten-1-yl]-β-D-allopyranosyl]-2-amino-5-hydroxy-3,6-dioxo-, (5S)-; Antibiotic LL RA 6950BB. CAS No. 11031-56-4. Molecular formula: C29H38N2O16S. Mole weight: 702.68.
Sennoside C
Aloe-emodin anthrone and rhein anthrone, formed mainly by intraluminal bacterial action, are the true active metabolites of Sennoside C in mice and that both anthrones synergistically exert their purgative effects on mice. Alternative Names: [9,9'-Bianthracene]-2-carboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-, (9R,9'R)-rel-; [9,9'-Bianthracene]-2-carboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-, (R*,R*)-; rel-(9R,9'R)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo[9,9'-bianthracene]-2-carboxylic acid; (R*,R*)-5,5'-bis(β-D-Glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-[9,9'-bianthracene]-2-carboxylic Acid. Grades: 98%. CAS No. 37271-16-2. Molecular formula: C42H40O19. Mole weight: 848.76.
Sennoside D
Sennoside D belongs to anthranoid family, and is procured from dried leaflets and pods of senna plant. Alternative Names: rel-(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo[9,9'-bianthracene]-2-carboxylic Acid; (R*,S*)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-[9,9'-bianthracene]-2-carboxylic Acid. Grades: 98%. CAS No. 37271-17-3. Molecular formula: C42H40O19. Mole weight: 848.76.
Septacidin
Septacidin is a glycoside antibiotic produced by the strain of Str. fimbriatus. It has anti-fungal effect. It inhibits L cells (NCTC 929) with ED50 of 25 ng/mL. It can inhibit sarcoma-180 and adenocarcinoma 755 cells in vivo. Alternative Names: N-(1H-Purin-6-yl)-4-[[[(14-methyl-1-oxopentadecyl)amino]acetyl]amino]-4-deoxy-β-L-glycero-L-gluco-heptopyranosylamine; NSC-65104; L-glycero-β-L-gluco-Heptopyranosylamine, 4-deoxy-4-[[2-[(14-methyl-1-oxopentadecyl)amino]acetyl]amino]-N-9H-purin-6-yl-; Antibiotic LIA 0191A. Grades: 99%. CAS No. 62362-59-8. Molecular formula: C30H51N7O7. Mole weight: 621.77.
Septamycin
It is a polyether antibiotic produced by the strain of Str. hygroscopicus NRRL 5678. It has anti-bacterial effect and is also effective against some drug-resistant bacteria (Resistance to penicillin, aminoglycoside antibiotics, etc). Alternative Names: Antibiotic A-28695A; 2H-Pyran-2-acetic acid, 6-[[(2R,3R,4R,5S,7S,9R,10R)-3,9-dimethoxy-2,4,10-trimethyl-2-[(2S,2'R,5R,5'R)-octahydro-5'-[(2S,3S,5R,6S)-tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]tetrahydro-2-hydroxy-4-methoxy-a,3,5-trimethyl-5-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy]-,(aR,2S,3S,4S,5S,6S)-; 2H-Pyran-2-acetic acid, 6-[[3,9-dimethoxy-2,4,10-trimethyl-2-[octahydro-5'-(tetrahydro-6-hydroxy-3,5,6-trimethyl-2H-pyran-2-yl)[2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]tetrahydro-2-hydroxy-4-methoxy-a,3,5-trimethyl-5-[(tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy]-, [2S-[2a,2(S*),3a,4b,5a(2R*,5R*,6S*),6b[2S*[2R*,2'S*,5S*,5'S*(2R*,3R*,5S*,6R*)],3S*,4S*,5R*,7R*,9S*,10S*]]]-. CAS No. 54927-63-8. Molecular formula: C48H82O16. Mole weight: 915.16.
Septamycin Sodium salt
It is a polyether antibiotic produced by the strain of Str. hygroscopicus NRRL 5678. It has anti-bacterial effect and is also effective against some drug-resistant bacteria (Resistance to penicillin, aminoglycoside antibiotics, etc). Alternative Names: Septamycin, monosodium salt. CAS No. 55924-40-8. Molecular formula: C48H81NaO16. Mole weight: 937.13.
Serratamolide
It is a depsipeptide antibiotic produced by the strain of Serratia marcescens HY-3. It has anti-gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak. Alternative Names: Serrawettin W1; serratamolide A; NSC 81415; Cyclic(D-beta-hydroxydecanoyl-L-seryl-D-beta-hydroxydecanoyl-L-seryl). CAS No. 5285-25-6. Molecular formula: C26H46N2O8. Mole weight: 514.65.
Seryl-arginine
Seryl-arginine is a dipeptide composed of serine and arginase. Alternative Names: Ser-Arg; L-Seryl-L-arginine. CAS No. 13261-11-5. Molecular formula: C9H19N5O4. Mole weight: 261.28.
Seryl-isoleucine
Seryl-isoleucine is a dipeptide composed of serine and isoleucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Alternative Names: L-Isoleucine, L-seryl-; Ser-Ile; H-SI-OH; L-seryl-L-isoleucine; L-Ser-L-Ile. Grades: ≥95%. CAS No. 91086-51-0. Molecular formula: C9H18N2O4. Mole weight: 218.25.
Seryl-lysine
Seryl-lysine is a dipeptide composed of serine and lysine. Alternative Names: L-Serinyl-L-lysine; seryl lysine. CAS No. 22677-61-8. Molecular formula: C9H19N3O4. Mole weight: 233.26.
Seryl-threonine
Seryl-threonine is a dipeptide composed of serine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism. Alternative Names: L-Threonine, L-seryl-; L-seryl-L-threonine; Ser-Thr; Serinylthreonine; ST dipeptide; L-Ser-L-Thr. Grades: ≥95%. CAS No. 61043-85-4. Molecular formula: C7H14N2O5. Mole weight: 206.20.
Seryl-tryptophan
Seryl-tryptophan is a dipeptide composed of serine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism. Alternative Names: Ser-Trp-OH; Ser-Trp; L-Tryptophan, L-seryl-; Seryltryptophan; S-W Dipeptide; Serine Tryptophan dipeptide; L-seryl-L-tryptophan; H-SW-OH. Grades: ≥95%. CAS No. 94421-70-2. Molecular formula: C14H17N3O4. Mole weight: 291.30.
Seryl-Valine
Seryl-Valine is a dipeptide composed of serine and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Alternative Names: H-SV-OH; L-seryl-L-valine; L-Valine, L-seryl-; Serinyl-Valine; L-Ser-L-Val. Grades: ≥95%. CAS No. 51782-06-0. Molecular formula: C8H16N2O4. Mole weight: 204.22.
Setosusin
Setosusin is a meroterpenoid fungal metabolite originally isolated from corynascus setosus. It reduces neurotoxicity induced by amyloid-β (Aβ) aggregates in PC12 cells (EC50 = 112.6 μM). In vivo, setosusin (30 mg/kg) induces tremors in mice. Grades: ≥99%. CAS No. 182926-45-0. Molecular formula: C29H38O8. Mole weight: 514.61.
SF-1623
SF-1623 is a cephamycin antibiotic produced by the the fermentation of Streptomyces chartreusis. It is active against gram-negative bacteria. Alternative Names: SF 1623. CAS No. 56487-86-6. Molecular formula: C15H21N3O10S3. Mole weight: 499.5.
SF 2315 A
SF 2315 A is a quinone antibiotic produced by Excellospora viridilutea SF2315. It exhibits inhibitory effect against Avian myelobastosis virus reverse transcriptase with IC50 of 100 μg/mL. It has weak activity against gram-positive bacteria. Alternative Names: Antibiotic SF 2315A; SF 2315A; SF2315A; cis-(+)-4a,5,6,12b-Tetrahydro-4a,8-dihydroxy-3-methylbenz(a)anthracene-1,7,12(4H)-trione. CAS No. 114687-52-4. Molecular formula: C19H16O5. Mole weight: 324.3.
SF 2315 B
SF 2315 B is a quinone antibiotic produced by Excellospora viridilutea SF2315. It exhibits inhibitory effect against Avian myelobastosis virus reverse transcriptase with IC50 of 40 μg/mL. It has weak activity against gram-positive bacteria. Alternative Names: Antibiotic SF 2315B; SF 2315B; SF2315B. CAS No. 114687-53-5. Molecular formula: C19H20O5. Mole weight: 344.4.
SF-2330
SF-2330 is a quinone antibiotic produced by Streptomyces sp. SF-2330. It exhibits activity against gram-positive bacteria. Alternative Names: Antibiotic SF-2330; SF 2330; 4H-Anthra(1,2-b)pyran-4,7,12-trione, 2-(2,2'-bioxiran)-2-yl-11-hydroxy-5-methyl-. CAS No. 103947-06-4. Molecular formula: C22H14O7. Mole weight: 390.3.
SF-2415A1
SF-2415A1 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415A1; SF 2415A1. CAS No. 110200-32-3. Molecular formula: C26H31ClN2O5. Mole weight: 487.
SF-2415A2
SF-2415A2 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415A2; SF 2415A2. CAS No. 110200-31-2. Molecular formula: C26H30N2O5. Mole weight: 450.5.
SF-2415A3
SF-2415A3 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415A3; SF 2415A3. CAS No. 110200-33-4. Molecular formula: C26H30Cl2N2O5. Mole weight: 521.4.
SF-2415B1
SF-2415B1 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415B1; SF 2415B1. CAS No. 110200-34-5. Molecular formula: C26H33ClO5. Mole weight: 461.
SF-2415B2
SF-2415B2 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415B2; SF 2415B2. Molecular formula: C26H32O5. Mole weight: 424.53.
SF-2415B3
SF-2415B3 is an antibiotic produced by Streptomyces aculeolatus. It is effective against gram-positive bacteria but inactive to gram-negative bacteria. Alternative Names: Antibiotic SF 2415B3; SF 2415B3. Molecular formula: C26H32Cl2O5. Mole weight: 495.43.
SF 2446A1
SF 2446A1 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Alternative Names: Antibiotic SF 2446A1; SF2446A1. Molecular formula: C34H35NO15. Mole weight: 697.6.
SF 2446A2
SF 2446A2 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Alternative Names: Antibiotic SF 2446A2; SF2446A2. Molecular formula: C34H35NO15. Mole weight: 697.6.
SF 2446A3
SF 2446A3. Alternative Names: SF2446A3. CAS No. 115834-24-7. Molecular formula: C26H21NO11. Mole weight: 523.4.
SF 2446B1
SF 2446B1 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Alternative Names: Antibiotic SF 2446B1; SF2446B1. Molecular formula: C34H35NO14. Mole weight: 681.6.
SF 2446B2
SF 2446B2. Alternative Names: SF2446B2. Molecular formula: C34H35NO14. Mole weight: 681.6.
SF2457
SF2457 is an antibiotic related to amicetin, which is isolated from the fermentation broth of Nocardia brasiliensis SF2457. It exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Alternative Names: SF-2457; SF 2457. CAS No. 115748-04-4. Molecular formula: C27H38N6O9. Mole weight: 590.6.
SF 2487
SF 2487 is a polyether antibiotic produced by Actinomadura sp. SF2487. It has moderate activity against gram-positive bacteria including staphylococcus and enterococcus with MIC of 0.10-0.39 μg/mL. It also effective against Influenza A virus. Alternative Names: SF-2487; SF2487; SF 2487 sodium salt; Antibiotic SF 2487 sodium salt; LS-70212. Molecular formula: C42H63NaO12. Mole weight: 782.9.
SF2738C
SF2738C is an antibiotic produced by the strain of Streptomyces sp. It has moderate activity against gram-positive, gram-negative bacteria and fungi. Alternative Names: SF-2738C; SF 2738C. Molecular formula: C13H14N2O2S. Mole weight: 262.33.
SF-773α
SF-773α is an antibiotic produced by Streptomyces sp. It is active against gram-positive bacteria. Alternative Names: SF 773α. Molecular formula: C17H34N4O10. Mole weight: 454.5.
Shincomycin B
It is a macrolide antibiotic produced by the strain of Str. flavochromogenes R-903. It has anti-gram-positive bacteria and mycoplasma activity, and has no cross-resistance with erythromycin and mycomycin. Grades: 99%. CAS No. 11053-05-7. Molecular formula: C52H90NO20. Mole weight: 1049.26.
SHP099
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo. Alternative Names: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine; SHP099; SHP-099; SHP 099. CAS No. 1801747-42-1. Molecular formula: C16H19Cl2N5. Mole weight: 352.26.
SHP099 HCl
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo. Alternative Names: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride; SHP099; SHP-099; SHP 099. SHP-099 hydrochloride, SHP-099 HCl. CAS No. 1801747-11-4. Molecular formula: C16H20Cl3N5. Mole weight: 388.72.
Shurimycin A
It is produced by the strain of Str. hygroscopicus A1491. It has anti-gram-positive bacteria and fungi effects. Alternative Names: Scopafungin, 2,3-didehydro-35-de[11-[[imino(methylamino)methyl]amino]-1,3-dimethyl-7-undecenyl]-2-demethyl-3-deoxy-35-[9-[[imino(methylamino)methyl]amino]-1-methyl-5-nonenyl]-30-methyl-; MBA 028-24A; Antibiotic MBA 028-24A. CAS No. 143906-47-2. Molecular formula: C56H95N3O17. Mole weight: 1082.36.
Shurimycin B
It is produced by the strain of Str. hygroscopicus A1491. It has anti-gram-positive bacteria and fungi effects. Alternative Names: Scopafungin, 35-[9-[[bis(methylamino)methylene]amino]-1-methyl-5-nonenyl]-2,3-didehydro-35-de[11-[[imino(methylamino)methyl]amino]-1,3-dimethyl-7-undecenyl]-2-demethyl-3-deoxy-30-methyl-; Antibiotic MBA 028-24B. CAS No. 143906-45-0. Molecular formula: C57H97N3O17. Mole weight: 1096.39.
Siastatin B
A-72363 B is a Heparanase inhibitor produced by Streptomyces nobilis SANK 60192. Alternative Names: A-72363 B; 3-Piperidinecarboxylic acid, 6-(acetylamino)-4,5-dihydroxy-, (3S-(3-alpha,4-alpha,5-alpha,6-beta))-; Siastatin B microbial; (2s,3r,4s,5s)-2-(Acetylamino)-5-Carboxy-3,4-Dihydroxypiperidinium. Grades: 95%. CAS No. 54795-58-3. Molecular formula: C8H14N2O5. Mole weight: 218.21.
Sibanomicin
It is produced by the strain of Micronconospora sp. SF2364. It has weak effect against gram-positive bacteria. Mice inoculated with leukemic P388 cells were given 2.1 and 1.0 mg/kg, which extended the survival time by 96% and 69% compared with the control group. Alternative Names: 7-[[3-C-Methyl-4-(methylamino)-4,6-dideoxy-α-L-mannopyranosyl]oxy]-1,2,3,11a-tetrahydro-2-[(E)-propylidene]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one; 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 7-[[4,6-dideoxy-3-C-methyl-4-(methylamino)-a-L-mannopyranosyl]oxy]-1,2,3,11a-tetrahydro-2-propylidene-, (2E)-; Antibiotic SF 2364. CAS No. 117782-84-0. Molecular formula: C23H31N3O5. Mole weight: 429.51.
Siccanin
It is a terpene antibiotic roduced by the strain of Helminthosporium siccans BH-34. It has activity against gram-negative bacteria, mycobacteria and fungi. Alternative Names: Siccaninum; Sicanina; Siccanine; 13H-Benzo(a)furo(2,3,4-mn)xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, (4aS-(4aalpha,6aalpha,11balpha,13aR*,13balpha))-; 1H,11bH,13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol,2,3,4,4a,5,6,6a,13b-octahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)-; (-)-Siccanin; NSC 135048. Grades: >98% by HPLC. CAS No. 22733-60-4. Molecular formula: C22H30O3. Mole weight: 342.47.
Siderochelin A
It is produced by the strain of Nocardia sp. SC 113, Act. sp. 69-209B-89. It has the effect against aerobic and anaerobic bacteria, and has anti-Gram-positive bacteria, Gram-negative bacteria and fungal effects but no anti-Candida albicans effect. The antibacterial activity of Siderochelin A is weaker than iron chelating agent Apoferrosamine. Fe2+, Fe3+, CO2+ and Zn2+ have antagonistic effects on Siderochelin A. Alternative Names: 2H-Pyrrole-2-carboxamide, 3,4-dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-methyl-, (2S,4R)-; 2H-Pyrrole-2-carboxamide, 3,4-dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-methyl-, (2S-trans)-; Antibiotic EM 4940A. CAS No. 77550-87-9. Molecular formula: C11H13N3O3. Mole weight: 235.24.
Siderochelin B
It is produced by the strain of Nocardia sp. SC 113, Act. sp. 69-209B-89. It has only weak effect against individual strains, such as E. coli. Alternative Names: (2R)-3,4-Dihydro-4β-hydroxy-5-(3-hydroxypyridin-2-yl)-4-methyl-2H-pyrrole-2β-carboxamide. CAS No. 77518-26-4. Molecular formula: C11H13N3O3. Mole weight: 235.24.
Siderochelin C
It is produced by the strain of Act. sp. 69-209B-89. It has only weak effect against individual strains, such as E. coli. Alternative Names: (2S)-3,4-Dihydro-4β-hydroxy-5-(3-hydroxypyridin-2-yl)-4-ethyl-2H-pyrrole-2α-carboxamide; (2S,4R,5Z)-4-ethyl-4-hydroxy-5-(3-oxopyridin-2-ylidene)pyrrolidine-2-carboxamide; 2H-Pyrrole-2-carboxamide, 4-ethyl-3,4-dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-, (2S-trans)-. CAS No. 93973-61-6. Molecular formula: C12H15N3O3. Mole weight: 249.27.
Simocyclinone D4
It is produced by the strain of Streptomyces antibioticus Tu 6040. It has moderate anti-gram-positive bacteria activity and has inhibitory effect on a variety of tumor cells. It inhibits HMO2, MCF7 and HEP G2 cells with GI50 (μmol/L) of 0.30, 5.6 and 8.5, respectively. Molecular formula: C46H43NO18. Mole weight: 897.83.
Simocyclinone D8
It is produced by the strain of Streptomyces antibioticus Tu 6040. It has moderate anti-gram-positive bacteria activity and has inhibitory effect on a variety of tumor cells. It inhibits HMO2, MCF7 and HEP G2 cells with GI50 (μmol/L) of 0.50, 0.95 and >50, respectively. Alternative Names: 9-[4-O-Acetyl-3-O-[10-[(8-chloro-4,7-dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]-1,10-dioxo-2,4,6,8-decatetraenyl]-2,6-dideoxy-beta-D-arabino-hexopyranosyl]-4a,5,6,12b-tetrahydro-4a,6,7,8,12b-pentahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracene-1,12(4H,7H)-dione; (1R)-4-O-acetyl-1,5-anhydro-3-O-{(2E,4E,6E,8E)-10-[(8-chloro-4,7-dihydroxy-2-oxo-2H-chromen-3-yl)amino]-10-oxodeca-2,4,6,8-tetraenoyl}-2,6-dideoxy-1-[(4aR,6S,6aS,7S,12aS,12bR)-4a,6,7,8,12b-pentahydroxy-3-methyl-1,12-dioxo-1,4,4a,5,6,7,12,12b-octahydro-6a,12a-epoxytetraphen-9-yl]-D-arabino-hexitol. Grades: ≥95%. CAS No. 301845-97-6. Molecular formula: C46H42ClNO18. Mole weight: 932.27.
Simonyellin
Simonyellin is a naphthopyran from the lichen Simonyella variegata Steiner. CAS No. 173322-91-3. Molecular formula: C14H10O6. Mole weight: 274.23.
Sinapaldehyde glucoside
Sinapaldehyde glucoside, also called Sinapaldehyde 4-O-beta-D-glucopyranoside, is a natural plant isolated from the barks of Phellodendron amurense. Alternative Names: Sinapaldehyde 4-O-beta-D-glucopyranoside. Grades: >95%. CAS No. 154461-65-1. Molecular formula: C17H22O9. Mole weight: 370.4.
(S)-Indacaterol
An isomerous impurity of Indacaterol. Indacaterol is an ultra-long-acting β-adrenoceptor agonist used as an oral inhaled bronchodilator. It is indicated for the treatment of patients with chronic obstructive pulmonary disease (COPD). Alternative Names: 5-[(1S)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone. Grades: 95%. CAS No. 1235445-80-3. Molecular formula: C24H28N2O3. Mole weight: 392.499.
Siomycin
Siomycin is a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G and aminoacyl-tRNA. It exhibits antitumor activity against certain cancer cell lines. CAS No. 11017-43-9. Molecular formula: C64H88N16O22S4. Mole weight: 1561.73.
Siomycin A
A macrocyclic antibiotic first isolated from S. sioyaensis with potent and selective antibacterial activity. It is a potent inhibitor of the oncogenic transcription factor, foxm1. It inhibits foxm1-induced cell growth on soft agar and selectively kills transformed but not normal cells in vitro. Alternative Names: Mutabilycin; Sporangiomycin; 6741-21; NSC 285116; Antibiotic 6741-21; (1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton; Thiostrepton, 1-Valine-2-(2,3-didehydroalanine)-. Grades: >95% by HPLC. CAS No. 12656-09-6. Molecular formula: C71H81N19O18S5. Mole weight: 1648.84.
Sirodesmin A
Sirodesmin A is a diketopiperazine antibiotic isolated from the culture broth of Microsphaeropsis sp. FL-16144. TAN-1496 inhibited the relaxation of supercoiled pBR322 DNA by calf thymus topoisomerase I but did not affect the decatenation of kinetoplast DNA by calf thymus topoisomerase II at concentration up to 500 microM. Alternative Names: TAN-1496B; TAN 1496B. CAS No. 52988-50-8. Molecular formula: C20H26N2O8S2. Mole weight: 486.6.
Sirodesmin B
It is produced by the strain of Sirodesmum diversum. It has antiviral effect. Alternative Names: Spiro[furan-2(3H),9'(10'H)-[5,11a](iminomethano)[11aH]cyclopenta[4,5]pyrrolo[2,1-e][1,2,3,4,6]tetrathiazocine]-3,6',12'(5'H)-trione, 10'-(acetyloxy)-4,5,7'a,8',10'a,11'-hexahydro-10'ahydroxy-5'-(hydroxymethyl)-4,4,5,13'-tetramethyl-, (2R,5'R,7'aR,10'S,10'aS,11aR)-. CAS No. 52988-51-9. Molecular formula: C20H26N2O8S4. Mole weight: 550.69.
Sirodesmin C
It is produced by the strain of Sirodesmum diversum. It has antiviral effect. Alternative Names: Spiro[furan-2(3H),8'(9'H)-[4,10a](iminomethano)[10aH]cyclopenta[4,5]pyrrolo[2,1-d][1,2,3,5]trithiazepine]-3,5',11'(4'H)-trione, 9'-(acetyloxy)hexahydro-9'a-hydroxy-4'-(hydroxymethyl)-4,4,5,12'-tetramethyl-, (2R,4'R,5R,6'aR,9'S,9'aS,10aR)-. CAS No. 52988-52-0. Molecular formula: C20H26N2O8S3. Mole weight: 518.62.
Sirodesmin G
It is produced by the strain of Sirodesmum diversum. It has antiviral effect. CAS No. 64599-26-4. Molecular formula: C20H26N2O8S2. Mole weight: 486.56.
Sisomicin B
It is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis. It has broad-spectrum antimicrobial activity. Alternative Names: Sisomicin B; 6-O-[3-Deoxy-3-(methylamino)-α-D-xylopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hexa-4-enopyranosyl)-2-deoxy-D-streptamine; Antibiotic 66-40B; 6640B; D-Streptamine, O-3-deoxy-3-(methylamino)-alpha-D-xylopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-. CAS No. 53797-16-3. Molecular formula: C18H35N5O7. Mole weight: 433.50.
Sisomicin D
It is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis. It has broad-spectrum antimicrobial activity. Alternative Names: 6-O-[3-Deoxy-3-(methylamino)-β-L-arabinopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hexa-4-enopyranosyl)-2-deoxy-D-streptamine; Antibiotic 66-40D; 66-40D. CAS No. 53759-50-5. Molecular formula: C18H35N5O7. Mole weight: 433.50.
Sisomicin sulfate (2:5)
Sisomicin Sulfate is an aminoglycoside antibiotic produced by the strain of Micromonospora inyoensis NRRL 3292. It has a broad-spectrum antibacterial effects against Gram-positive and Gram-negative bacteria. Uses: Anti-bacterial agents. Alternative Names: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5); D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5) (salt); Antibiotic 66-40 sulfate; Baymicin; Extramycin; Mensiso; Sisobiotic; Sisolline; Sisomicin sulfate; Sisomin; Sisomycin sulfate; Sissomicin sulfate. Grades: ≥95%. CAS No. 53179-09-2. Molecular formula: C19H37N5O7.5/2H2O4S. Mole weight: 1385.44.
SLC-0111
SLC-0111, also known as U-104, MST-104 and NSC 213841, is a potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells). U-104 associates with CAIX / CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models. Alternative Names: 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide; SLC-0111; SLC0111; SLC 0111; MST-104; MST-104; MST-104; NSC-213841; NSC213841; NSC 213841; U-104; U104; U 104. CAS No. 178606-66-1. Molecular formula: C13H12FN3O3S. Mole weight: 309.31.
SM 196A
SM 196A is a quinone antibiotic produced by Streptomyces sp. DMS 4769. It exhibits activity against gram-positive bacteria. Alternative Names: SM-196A. CAS No. 135635-82-4. Molecular formula: C20H20O5. Mole weight: 340.4.
SM 196B
SM 196B is a quinone antibiotic produced by Streptomyces sp. DMS 4769. Its activity against gram-positive bacteria is more potent than that of SM 196A. It also has anti-Herpes simplex virus activity. Alternative Names: SM-196B. CAS No. 135635-83-5. Molecular formula: C20H18O5. Mole weight: 338.4.
SMTP-1
SMTP-1 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C25H35NO5. Mole weight: 429.5.
SMTP-2
SMTP-2 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. The activity of SMTP-2 is weaker than SMTP-1. Molecular formula: C25H37NO7. Mole weight: 463.6.
SMTP-3
SMTP-3 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C26H35NO7. Mole weight: 473.6.
SMTP-4
SMTP-4 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C32H39NO6. Mole weight: 533.7.
SMTP-5
SMTP-5 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C29H41NO6. Mole weight: 499.6.
SMTP-6
SMTP-6 is a Staplabin homolog isolated from Stachybotrys microspora IFO30018. It enhanced the binding of Plasminogen to Fibrin. Molecular formula: C34H40N2O6. Mole weight: 572.7.
(+)-S-Myricanol glucoside
(+)-S-Myricanol glucoside is a natural phenol isolated from the root bark of Myrica cerifera L. Alternative Names: Epimyricanol glucoside. Grades: >98%. CAS No. 449729-89-9. Molecular formula: C27H36O10. Mole weight: 520.6.