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Valsartan methyl ester
An impurity of Valsartan. Valsartan is an antagonist of angiotensin II receptor mainly used for the treatment of high blood pressure and congestive heart failure. Synonyms: Valsartan Methyl Ester; N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine Methyl Ester; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-Valine Methyl Ester; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine Methyl Ester. Grade: 98.0%. CAS No. 137863-17-3. Molecular formula: C25H31N5O3. Mole weight: 449.56.
Vandetanib-[d4]
Vandetanib-[d4] is the labelled analogue of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Synonyms: Vandetanib D4; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[[1-methyl-4-(piperidinyl-d4)]methoxy]-4-quinazolinamin. Grade: 95% by HPLC; 98% atom D. CAS No. 1215100-18-7. Molecular formula: C22H20D4BrFN4O2. Mole weight: 479.38.
Vanillin-[13C6]
A labelled Vanillin, which occurs naturally in a wide variety of foods and plants such as orchids. Major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes. Synonyms: Rhovanil-13C6; P-Vanillin-13C6; Lioxin-13C6; Vanillaldehyde-13C6; [U-Ring-13C6]-Vanillin. CAS No. 201595-58-6. Molecular formula: [13C]6C2H8O3. Mole weight: 158.103.
Vanillin-[methoxy-d3]
Vanillin-[methoxy-d3] is a labelled analogue of Vanillin which is mostly used for flavoring foods. Synonyms: 4-Hydroxy-3-methoxy-d3 benzaldehyde; Vanillin-d3. Grade: 99% by CP; 99% atom D. CAS No. 74495-74-2. Molecular formula: C8H5D3O3. Mole weight: 155.17.
Vapendavir-[d5]
One of the isotopic labelled form of Vapendavir, which is a rhinovirus replication inhibitor. Synonyms: 3-(D5)ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzoxazole; [D5]-Vapendavir; 3-Ethoxy-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-1,2-benzisoxazole-d5. Molecular formula: C21H21D5N4O3. Mole weight: 387.49.
Vardenafil-[d4]
An isotope labelled form of Vardenafil. Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Synonyms: 2-(2-ethoxy-5-{[4-ethyl(2,2,3,3-D4)piperazin-1-yl]sulfonyl}phenyl)-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one. Grade: 95% by HPLC; 98% atom D. CAS No. 2012598-83-1. Molecular formula: C23H28D4N6O4S. Mole weight: 492.63.
Vardenafil-[d5]
Vardenafil-[d5] is the labelled analogue of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: Vardenafil-d5; 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-(ethyl-d5)-piperazine. Grade: 95% by HPLC; 98% atom D. CAS No. 1189685-70-8. Molecular formula: C23H27D5N6O4S. Mole weight: 493.63.
Varenicline-[13C2,15N2]
An isotope labelled derivative of Varenicline. Varenicline is a medication used to treat nicotine addiction. Grade: 95% by HPLC; 98% atom 13C; 98% atom 15N. CAS No. 2140265-12-7. Molecular formula: C11[13C]2H13N[15N]2. Mole weight: 215.23.
Varenicline-[d4]
Varenicline-[d4] is the labelled analogue of Varenicline, which is a partial agonist of nicotinic receptor used for smoking cessation. It reduces both the desire for and the pleasure of cigarettes. Synonyms: Varenicline-d4; Varenicline D4; 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine-d4 Hydrochloride. CAS No. 2183239-01-0. Molecular formula: C13H9D4N3. Mole weight: 215.29.
Varenicline tartrate
Varenicline (trade name Chantix in the USA and Champix in Canada, Europe and other countries, marketed by Pfizer, usually in the form of varenicline tartrate), is a prescription medication used to treat nicotine addiction. Varenicline is a nicotinic receptor partial agonist-it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms it can assist some patients to quit smoking. Synonyms: 7; 8; 9; 10-tetrahydro-6H-6; 10-methanoazepino[4; 5-g]quinoxaline (2R; 3R)-2; 3-dihydroxysuccinate; Champix (TN); 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene L-tartrate; 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate Champix; CP-526555-18; CP 526555 18; CP52655518; Chantix; Champix. Grade: ≥ 95%. CAS No. 375815-87-5. Molecular formula: C17H19N3O6. Mole weight: 361.35.
Vasopressin-[d5]
Vasopressin-[d5] is a labelled analogue of Vasopressin. Vasopressin is a neurohypophysial hormone existing in most mammals. It has the function of regulating body's water retention via antidiuretic activity. Vasopressin is a peptidic V1a receptor agonist that can increase blood pressure by contracting the blood vessels. Synonyms: Arginine Vasopressin-d5; 19-Amino-13-(benzyl-d5)-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide; 3-(Phenylalanine)-8-arginineoxytocin-d5; 8-L-Arginine-vasopressin-d5; AVP-d5; Arg8-vasopressin-d5; Arginine antidiuretic hormone-d5; Arginine-8-vasopressin-d5; Arginine-vasopressin-d5; Argipressin-d5; Leiormone-d5; [8-Arginine]vasopressin-d5; 3-(L-Phenylalanine)-8-L-arginine-oxytocin-d5; Pitressin-d5; Rindervasopressin-d5; L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide Cyclic (1→6)-Disulfide-d5. Grade: >98%. CAS No. 1356383-11-3. Molecular formula: C46H60D5N15O12S2. Mole weight: 1089.28.
Vc-MMAD
Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. Uses: Adcs cytotoxin-linker. Synonyms: Vc MMAD; VcMMAD. Grade: >98%. CAS No. 1401963-17-4. Molecular formula: C70H104N12O14S. Mole weight: 1369.71.
Vedaprofen-[d3]
Vedaprofen-[d3] is the labelled analogue of Vedaprofen, which is a propionic acid nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of inflammations and pains. Synonyms: Vedaprofen-D3; 2-(4-Cyclohexylnaphthalen-1-yl)-propionic acid-D3; 4-Cyclohexyl-α-(methyl-d3)-1-naphthaleneacetic Acid; 2-(4-Cyclohexil-1-naphthyl)propionic Acid-d3; Quadrisol-d3. Grade: 95% by HPLC; 98% atom D. CAS No. 1185054-34-5. Molecular formula: C19H19D3O2. Mole weight: 285.40.
Vemurafenib-[d7]
Vemurafenib-[d7] is the labelled analogue of Vemurafenib, which is a B-Raf enzyme inhibitor used for the treatment of late-stage melanoma. Synonyms: Vemurafenib D7. CAS No. 1365986-73-7. Molecular formula: C23H11D7ClF2N3O3S. Mole weight: 496.97.
Venetoclax-[d8]
An isotope labelled Venetoclax. Venetoclax can be used to treat chronic lymphocytic leukemia. Synonyms: 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[3-nitro-4-({[(2,2,3,3,5,5,6,6-D8)oxan-4-yl]methyl}amino)benzenesulfonyl]-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide. Grade: 95% by HPLC; 98% atom D. CAS No. 1257051-06-1. Molecular formula: C45H42D8ClN7O7S. Mole weight: 876.50.
Venlafaxine
Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class, but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is licensed for the treatment of major depressive disorder (MDD), as the treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. It can increase dopamine neurotransmission in this part of the brain. It has seemingly superior efficacy in severe depression as a narcotic and is increasingly used as a measure of last resort for refractory cases. Synonyms: Wy 45030; Wy45030; Wy-45030; Effexor; Elafax. Grade: >98%. CAS No. 93413-69-5. Molecular formula: C17H27NO2. Mole weight: 277.4.
Venlafaxine-[d10] Hydrochloride
One of the isotopic labelled form of Venlafaxine HCl, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used as an antidepressant. Venlafaxine is commonly used to treat depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms. Synonyms: D,L-Venlafaxine-d10 Hydrochloride; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride-d10. CAS No. 1216539-56-8. Molecular formula: C17H18D10ClNO2. Mole weight: 323.92.
Venlafaxine-[d6] hydrochloride
An isotope labelled derivative of Venlafaxine. Venlafaxine is a selective serotonin-norepinephrine reuptake inhibitor as an antidepressant. Grade: 95% by HPLC; 98% atom D. CAS No. 1062606-12-5. Molecular formula: C17H22D6ClNO2. Mole weight: 319.90.
Venlafaxine hydrochloride
Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class, but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. It works by blocking the transporter reuptake proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. It can increase dopamine neurotransmission in this part of the brain. It is seemingly superior efficacy in severe depression as narcotics become increasingly used as a measure of last resort for refractory cases. Uses: Antidepressant. Synonyms: Wy-45030; Wy45030; Wy 45030; Effexor hydrochloride; Effexor; VENLAFAXINE HCl; Effexor XR; Trevilor. Grade: >98%. CAS No. 99300-78-4. Molecular formula: C17H28ClNO2. Mole weight: 313.86.
(±)-Verapamil-d3 hydrochloride
(±)-Verapamil-d3 hydrochloride is intended for use as an internal standard for the quantification of verapamil hydrochloride by GC- or LC-MS. Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Synonyms: 5-((3,4-dimethoxyphenethyl)(methyl-d3)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile monohydrochloride. Grade: ≥98%. Molecular formula: C27H35D3N2O4·HCl. Mole weight: 494.1.
Verapamil-[d7] Hydrochloride
Verapamil-[d7] Hydrochloride is the labelled analogue of Verapamil Hydrochloride, which is a calcium channel blocker used as antihypertensive, antianginal and antiarrhythmic. Synonyms: Verapamil D7 Hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl-d7)-benzeneacetonitrile Hydrochloride. Grade: 95% by HPLC; 98% atom D. CAS No. 1188265-55-5. Molecular formula: C27H32D7ClN2O4. Mole weight: 498.11.
Verlukast-[d6]. Uses: A receptor antagonist for the treatment of respiratory diseases. Synonyms: Verlukast D6. Grade: 95% atom D. CAS No. 153698-86-3. Molecular formula: C26H21D6ClN2O3S2. Mole weight: 521.12.
(±)-Vesamicol hydrochloride
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM) that blocks the loading of acetylcholine into synaptic vesicles of cholinergic nerve terminals. The inhibition by Vesamicol attenuates acetylcholine neuronal signaling without direct effecys on signaling mechanisms. Synonyms: AH5183 hydrochloride; AH 5183 hydrochloride; (±)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride; 2-(4-Phenylpiperidino)cyclohexanol hydrochloride; Cyclohexanol, 2-(4-phenylpiperidino)-, hydrochloride. Grade: ≥99% by HPLC. CAS No. 120447-62-3. Molecular formula: C17H25NO.HCl. Mole weight: 295.85.
Vicagrel Carboxylic Acid-[d4]
One of the isotopic labelled impurities of Vicagrel, which is a prodrug of clopidogrel thiolactone, an oral P2Y12 antiplatelet agent used to prevent blood clots, developed to overcome clopidogrel resistance. Synonyms: (2S)-2-[2-(acetyloxy)-4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl]-2-[2-chloro(D4)phenyl]acetic acid. Molecular formula: C17H12D4ClNO4S. Mole weight: 369.86.
Vicagrel-[d4]
One of the labelled form of Vicagrel, which is a prodrug of clopidogrel thiolactone, an oral P2Y12 antiplatelet agent used to prevent blood clots, developed to overcome clopidogrel resistance. Synonyms: methyl (2S)-2-[2-(acetyloxy)-4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl]-2-[2-chloro(3,4,5,6-D4)phenyl]acetate. Molecular formula: C18H14D4ClNO4S. Mole weight: 383.89.
Vicriviroc-[13C,d3]
Vicriviroc-[13C,d3] is the labelled analogue of Vicriviroc, which is an antagonist of CCR5 receptor against human immunodeficiency virus. Vicriviroc inhibits the entry of HIV into CD4 cells via binding to CCR5. Synonyms: Vicriviroc-13C,d3. Molecular formula: C27[13C]H35F3N5O2D3. Mole weight: 537.65.
Vilazodone-[d8]
Vilazodone-[d8] is the labelled analogue of Vilazodone. Vilazodone is a serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist that is used for the treatment of major depressive disorder. Synonyms: Vilazodone D8. Grade: 98% by HPLC; 98% atom D. CAS No. 1794789-93-7. Molecular formula: C26H19D8N5O2. Mole weight: 449.57.
Vilazodone hydrochloride
Vilazodone is a serotonin 5-HT1A partial agonist and serotonin-selective reuptake inhibitor (SPARI) that is used clinically as an antidepressant for major depressive disorder. Uses: Antidepressive agents. Synonyms: EMD 68843; SB 659746A; EMD-68843; EMD68843; SB-659746A; SB659746A. Grade: >98%. CAS No. 163521-08-2. Molecular formula: C26H28ClN5O2. Mole weight: 477.99.
Vildagliptin
Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from there use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic. Uses: Dipeptidyl-peptidase iv inhibitors. Synonyms: LAF237; LAF 237; LAF-237; Galvus; NVP-LAF 237; Zomelis; Xiliarx; Jalra; DSP 7238; DSP-7238; DSP7238; Vildagliptin; Zomelis. Grade: 98%. CAS No. 274901-16-5. Molecular formula: C17H25N3O2. Mole weight: 303.406.
Vildagliptin-[d6]
Vildagliptin-[d6] is the labeled analogue of Vildagliptin. Vildagliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor that is used as an anti-hyperglycemic agent. Vildagliptin could reduce hyperglycemia in type 2 diabetes mellitus via the suppressive effect of inactivation of GLP-1 and GIP by DPP-4. Synonyms: Vildagliptin D6; Vildagliptin-d6; (2S)-1-[[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-pyrrolidine-2-carbonitrile-3,3,4,4,5,5-d6; (S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile-3,3,4,4,5,5-d6; Vidagliptin-d6; Xiliarx-d6. Grade: >95%. CAS No. 2747956-23-4. Molecular formula: C17H19N3O2D6. Mole weight: 309.44.
Vildagliptin-[d7]
Vildagliptin-[d7] is the labelled analogue of Vildagliptin, a DPP-4 inhibitor used as an anti-diabetic drug. Synonyms: Vildagliptin D7. Grade: 98% by HPLC; 98% atom D. CAS No. 1133208-42-0. Molecular formula: C17H18D7N3O2. Mole weight: 310.4.
Vinyl-[13C2] acetate
Vinyl-[13C2] acetate. Synonyms: Ethenyl Acetate-13C2. Grade: ≥99% by CP; ≥99% atom 13C. CAS No. 106139-40-6. Molecular formula: C2[13C]2H6O2. Mole weight: 88.07.
Vinyl chloride-[d3]
Vinyl chloride-[d3]. Synonyms: Chloro(2H3)ethene; Vinyl chloride-d3. Grade: 98% by CP; 98% atom D. CAS No. 6745-35-3. Molecular formula: C2D3Cl. Mole weight: 65.52.
Vinyl-[d3] Bromide
Vinyl-[d3] Bromide. Synonyms: Vinyl-d3 Bromide; Bromo(2H3)ethene; Perdeuteriovinyl Bromide. Grade: 95% atom D. CAS No. 4666-78-8. Molecular formula: C2D3Br. Mole weight: 109.97.
Vioxx-[d5]
Vioxx-[d5] is the labelled analogue of Rofecoxib. Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Synonyms: Vioxx D5; 4-[4-(Methylsulfonyl)phenyl]-3-(phenyl-d5)-2(5H)-furanone; 3-(4-Methanesulfonylphenyl)-2-(phenyl-d5)-2-buten-4-olide. Grade: 95% by HPLC; 95% atom D. CAS No. 544684-93-7. Molecular formula: C17H9D5O4S. Mole weight: 319.39.
Vismodegib-[d4]
Vismodegib-[d4] is the labelled analogue of Vismodegib, which has been found to inhibit Hh signaling and could probably be effective in anticancer studies. Synonyms: Vismodegib D4; 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 1450990-33-6. Molecular formula: C19H10D4Cl2N2O3S. Mole weight: 425.32.
Vitamin B3-[13C6]
An isotope labelled form of Nicotinamide. Nicotinamide is a vitamin found in food. It can be used as a dietary supplement and a medication. Synonyms: Nicotinamide-13C6; 3-(Aminocarbonyl)pyridine-13C6; 3-Amidopyridine-13C6; 3-Carbamoylpyridine-13C6; 3-Pyridinecarboxylic Acid Amide-13C6; Aminicotin-13C6; Benicot-13C6; Delonin Amide-13C6; Dipegyl-13C6; NAM-13C6; NSC 13128-13C6; NSC 27452-13C6; Niacinamide-13C6; Nicosylamide-13C6; Nicotilamide-13C6; Nicotine Acid Amide-13C6; Nicotinic Acid Amide-13C6; Nicotinic Amide-13C6; Nicotylamide-13C6; Nicovit-13C6; Nicovitina-13C6; Nictoamide-13C6. Grade: 95% by HPLC; 98% atom 13C. Molecular formula: [13C]6H6N2O. Mole weight: 128.08.
Vitamin D2-[6,19,19-d3]
Vitamin D2-[6,19,19-d3] is the labelled analogue of Vitamin D2, a fat-soluble vitamin important for many biochemical processes including the absorption and metabolism of calcium and phosphorus. Synonyms: Vitamin D2 (6,19,19-d3); VD2-D3; Vitamin D2-d3; (1S,?3Z)?-4-(Methylene-d2)?-3-[(2E)?-2-[(1R,?3aS,?7aR)?-octahydro-7a-methyl-1-[(1R,?2E,?4R)?-1,?4,?5-trimethyl-2-hexen-1-yl]?-4H-inden-4-ylidene]?ethylidene-1-d]?-Cyclohexanol; Ergocalciferol-6,19,19-d3; Calciferol-6,19,19-d3; Viosterol-d3; Oleovitamin D2-d3; Deltalin-d3; Ercalciol-6,19,19-d3. Grade: 98% by CP; 97% atom D. CAS No. 1217448-46-8. Molecular formula: C28H41D3O. Mole weight: 399.67.
Vitamin D3-[d7]
Vitamin D3-[d7] is the labelled analogue of Vitamin D3, which has been found to be effective in mediating intestinal calcium absorbtion and bone calcium metabolism. Synonyms: (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol-d7; Vitamin D3-d7. Grade: 95% by HPLC; 95% atom D. CAS No. 1627523-19-6. Molecular formula: C27H37D7O. Mole weight: 391.68.
Vitamin E-[d3] (R,R,R)
An isotope labelled form of Vitamin E. Vitamin E has many biological functions, including its role as a fat-soluble antioxidant. Synonyms: (R)-2,5,7-trimethyl-8-trideuteromethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol; (2R,4'R,8'R)-alpha-Tocopherol-D3. Grade: 98% by HPLC; 98% atom D. Molecular formula: C29H47D3O2. Mole weight: 433.72.
Vitamin E-[d6] (R,R,R)
An isotope labelled of Vitamin E. Vitamin E has many biological functions, including its role as a fat-soluble antioxidant. Synonyms: (2R,4'R,8'R)-alpha-Tocopherol-D6; (R)-2,7-dimethyl-5,8-bis(trideuteromethyl)-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol. Grade: 98% by HPLC; 93% atom D. Molecular formula: C29H44D6O2. Mole weight: 436.47.
Vitamin E-[d6] (R,R,R) acetate
An isotope labelled derivative of Vitamin E. Vitamin E has many biological functions, including its role as a fat-soluble antioxidant. Synonyms: (R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl acetate-D6; (2R,4'R,8'R)-alpha-Tocopherol acetate-D6; (2R,4'R,8'R)-O-acetyl-5-methyl-7,8-bis(trideuteromethyl)tocol; (S)-2,7-dimethyl-5,8-bis(trideuteromethyl)-2-((4S,8S)-4,8,12-trimethyltridecyl)chroman-6-yl acetate. Grade: 98% by HPLC; 93% atom D. Molecular formula: C31H46D6O3. Mole weight: 478.78.
Vitamin K1-[d7]
An isotope labelled Phytomenadione. Phytomenadione is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat certain bleeding disorders. Synonyms: Vitamin K1-d7; Phylloquinone-d7; phytonadione-d7; Phytomenadione-d7; 3-Phytylmenadione-d7; alpha-Phylloquinone-d7; Fitomenadiona-d7; trans-Phylloquinone-d7; 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl]-1,4-naphthalenedione-d7; Konakion-d7; Mephyton-d7; Synthex P-d7; Veda K1-d7; α-Phylloquinone-d7; 2',3'-trans-Vitamin K1-d7. Grade: ≥95%; ≥97% atom D. CAS No. 1233937-39-7. Molecular formula: C31H39D7O2. Mole weight: 457.74.
Vitamin K3-[d8]
Vitamin K3-[d8]. Uses: Precursor to verious types of vitamin k. used as a micronutrient for livestock and pet foods. Synonyms: 2-Methyl-1,4-naphthoquinone-d8; 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene-d8; 2-Methyl-1,4-naphthalenedione-d8; Aquakay-d8; Aquinone-d8; Hemodal-d8; K-Thrombyl-d8; K-Vitan-d8; Kaergona-d8; Kanone-d8; Kappaxan-d8; Kappaxin-d8; Karcon-d8; Kareon-d8; Kativ-G-d8; Kayklot-d8; Klottone-d8; Koaxin-d8; Kolklot-d8; MNQ-d8; Menadion-d8; Menadione-d8; Menaphthon-d8; Menaphthone-d8; Menaquinone 0-d8; NSC 4170-d8; Panosine-d8; Prokayvit-d8; Synkay-d8; Thyloquinone-d8. Grade: 97% by CP; 98% atom D. CAS No. 478171-80-1. Molecular formula: C11D8O2. Mole weight: 180.23.
Vorapaxar-[d5]
One of the isotopic labelled form of Vorapaxar, which has been found to be an antiplatelet agent and could be potentially effective against atherothrombosis. Synonyms: (1,1,2,2,2-D5)ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-dodecahydronaphtho[2,3-c]furan-6-yl]carbamate. Grade: >98%. Molecular formula: C29H28D5FN2O4. Mole weight: 497.61.
(±)-Voriconazole
(±)-Voriconazole is an impurity of Voriconazole, which is an antifungal medication used to treat a number of fungal infections. Synonyms: 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel-; 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (R*,S*)-; rel-(αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (R*,S*)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; rel-(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (2R,3S/2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol. CAS No. 188416-29-7. Molecular formula: C16H14F3N5O. Mole weight: 349.31.
Voriconazole-[d3]
Voriconazole-[d3] is the labelled analogue of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: (±)-Voriconazole-d3; (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-(methyl-d3)-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; UK-109496-d3; VRC-d3; Vfend-d3; Voriconazol-d3. Grade: 95% by HPLC; 98% atom D. CAS No. 1217661-14-7. Molecular formula: C16H11D3F3N5O. Mole weight: 352.34.
Voriconazole-[d3] N-Oxide
Voriconazole-[d3] N-Oxide is the labelled analogue of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: Voriconazole-d3 N-Oxide; (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-d3-α-(1H-1,2,4-triazol-1-ylmethyl)-1-oxide-4-pyrimidineethanol. Grade: 95% by HPLC; 98% atom D. CAS No. 1217851-84-7. Molecular formula: C16H11D3F3N5O2. Mole weight: 368.33.
Vorinostat-[d5]
SAHA-d5 is a labelled suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor. Synonyms: Vorinostat D5. Grade: 98% by HPLC; 98% atom D. CAS No. 1132749-48-4. Molecular formula: C14H15D5N2O3. Mole weight: 269.35.
Vortioxetine-[d8]
One of the isotopic labelled form of Vortioxetine,which is a 5-HT receptor inhibitor as well as a serotonin transporter, and has been found to be an atypical antidepressant. Synonyms: 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine-d8; 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine-d8. Grade: ≥90%. CAS No. 2140316-62-5. Molecular formula: C18H14D8N2S. Mole weight: 306.50.
Vortioxetine-[d8] HCl
An isotope labelled derivative of Vortioxetine. Vortioxetine is an antidepressant medication that is prescribed to treat depression. Synonyms: 1-[2-[[2,4-Di(methyl)phenyl]thio]phenyl]piperazine-2,2,3,3,5,5,6,6-d8. Grade: 95% by HPLC; 98% atom D. Molecular formula: C18H15D8ClN2S. Mole weight: 342.91.
VX-561
VX-561, also known as d9-ivacaftor, is an agonist of cystic fibrosis transmembrane conductance regulator (CFTR) channel developed for the treatment of cystic fibrosis. VX-561 is in a phase II clinical trial for safety and efficacy evaluation. Uses: Potential treatment of cystic fibrosis. Synonyms: CTP-656; N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide; d9-ivacaftor. CAS No. 1413431-07-8. Molecular formula: C24H19D9N2O3. Mole weight: 401.55.
Warfarin-[d5]
One of the isotopic labelled form of Warfarin, which is a kind of Coumarin anticoagulant. Synonyms: 4-Hydroxy-3-(3-oxo-1-phenyl-d5-butyl)-2H-1-benzopyran-2-one; 3-(α-Acetonylbenzyl)-4-hydroxy-coumarin-d5; Warf compound 42-d5; Rodex-d5; Sakarat X-d5. Grade: 95% by HPLC; 98% atom D. CAS No. 75472-93-4. Molecular formula: C19H11D5O4. Mole weight: 313.37.
Water-[18O]. Synonyms: 18O Water; Water O-18; heavy-oxygen water. Grade: 97% atom 18O. CAS No. 14314-42-2. Molecular formula: H2[18O]. Mole weight: 20.02.
(-)-WAY 100135 dihydrochloride
(-)-WAY 100135 dihydrochloride is a selective serotonin 5-HT1A antagonist. Synonyms: WAY 100135 dihydrochloride; WAY100135 dihydrochloride; WAY-100135 dihydrochloride; (2R)-N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide dihydrochloride. Grade: 99%. CAS No. 149007-53-4. Molecular formula: C24H33N3O2.2HCl. Mole weight: 468.46.
(-)-WIN 55,212-3 mesylate
(-)-WIN 55,212-3 is an aminoalkylindole derivative which acts as a competitive neutral antagonist of the human cannabinoid CB2 receptor and presumably express the CB1 receptor. It also weakly antagonizes the melatonin MT1 and muscarinic M4 receptors but has no effect on several other G protein-coupled receptors. Synonyms: [(11S)-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-ylmethanone mesylate. Grade: ≥98%. CAS No. 131543-25-4. Molecular formula: C27H26N2O3·CH3SO3H. Mole weight: 522.6.
Xanthine-[13C,15N2]
Xanthine-[13C,15N2] is the labelled analogue of Xanthine, which is a kind of purine compound, widely existed, and has been found to exhibit adenoside receptor antagonist activities. Synonyms: Xanthine-13C 15N2; 3,9-Dihydro-1H-purine-2,6-dione-13C,15N2. Grade: 95% by HPLC; 98% atom 13C; 98% atom 15N. CAS No. 1262670-81-4. Molecular formula: C4[13C]H4N2[15N]2O2. Mole weight: 155.09.
(-)-Xestospongin C
(-)-Xestospongin C is a potent and reversible inhibitor of IP3 receptor that reguates calcium release. (-)-Xestospongin C has been found to inhibit bradykinin-induced Ca2+ release in PC12 cells and attenuate PHP-induced IL-2 production in Jurkat T cells, but exhibits no effect on ryanodine receptor-mediated Ca2+ release in PC12 cells. Synonyms: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine; Xestospongin C. CAS No. 88903-69-9. Molecular formula: C28H50N2O2. Mole weight: 446.71.
xylitol-[1,1',2,3,4,5,5'-d7]
xylitol-[1,1',2,3,4,5,5'-d7]. Synonyms: [UL-2H7]xylitol; [1,1',2,3,4,5,5'-2H7]xylitol; xylitol-1,1,2,3,4,5,5-d7; xylitol-C-d7. Grade: 98% (CP); 99% atom D. Molecular formula: C5H5D7O5. Mole weight: 159.19.
One of the isotopic labelled form of Yohimbine, an indole alkaloid compound, has been found to exhibit α2-adrenergic blocking effect and could be used in the treatment of neurological disorders. Synonyms: Yohimbine-(methyl-13C,d3 ester). Grade: ≥98% atom (CP); ≥99% atom. CAS No. 1261254-59-4. Molecular formula: C20[13C]H23D3N2O3. Mole weight: 358.45.
Zafirlukast-[13C,d3]
One of the isotopic lebelled form of Zafirlucast, which has been found to be a cysteinyl leukotriene type 1 receptor antagonist and could be as an antiasthmatic agent. Synonyms: cyclopentyl (3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methyl-1H-indol-5-yl)carbamate-13CD3. Grade: >99%. Molecular formula: C30[13C]H30D3N3O6S. Mole weight: 579.70.
Zafirlukast-[d7]
One of the isotopic lebelled form of Zafirlucast, which has been found to be a cysteinyl leukotriene type 1 receptor antagonist and could be as an antiasthmatic agent. Synonyms: [3-[[2-Methoxy-4-[[[(2-methylphenyl-d7)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester. Grade: >98%. CAS No. 1217174-18-9. Molecular formula: C31H26D7N3O6S. Mole weight: 582.73.
Zafirlukast m-Tolyl Isomer-[d7]
Zafirlukast m-Tolyl Isomer-[d7] is the labelled analogue of Zafirlukast m-Tolyl Isomer, which is a positional isomer and impurity of the cysteinyl leukotriene type 1 receptor antagonist, Zafirlukast. Synonyms: Zafirlukast m-Tolyl Isomer-d7; N-[3-[[2-Methoxy-4-[[[(3-methylphenyl-d7)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester; Zafirlukast Related Compound D-d7; Cyclopentyl 3-[2-Methoxy-4-[m-(tolyl-d7)sulfonylcarbamoyl)benzyl]-1-methylindol-5-ylcarbamate. Grade: ≥98%. CAS No. 1794760-52-3. Molecular formula: C31H26D7N3O6S. Mole weight: 582.72.
Zaltoprofen-[d3]
One of the isotopic labelled form of Zaltoprofen, which could inhibit bradykinin-induced pain and could be used as a non-steroidal anti-inflammatory agent. Synonyms: 2-(10,11-Dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid-d3; 10,11-Dihydro-α-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic Acid-d3. Grade: >98%. Molecular formula: C17H11D3O3S. Mole weight: 301.37.
Zanamivir-[13C,15N2]
Zanamivir-[13C,15N2] is the labelled analogue of Zanamivir, which is an acetylneuraminic derivative and has been found to be an influenza viral neuraminidase inhibitor. Synonyms: Zanamivir-13C,15N2; 5-Acetylamino-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic Acid-13C,15N2. Grade: 95% by HPLC; 98% atom 13C; 98% atom 15N. CAS No. 1276528-62-1. Molecular formula: C11[13C]H20N2[15N]2O7. Mole weight: 335.29.
(±)-Zanubrutinib
(±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibition in the tissues than ibrutinib. Uses: Antineoplastic agents. Synonyms: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)-; 4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; 7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide; DL-Zanubrutinib; (±)-BGB-3111. CAS No. 1633350-06-7. Molecular formula: C27H29N5O3. Mole weight: 471.55.