BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Sialyl Lewis X methyl glycoside | Sialyl Lewis X methyl glycoside, a synthetic carbohydrate molecule employed in biomedical research, provides unique insight into the molecular mechanisms underlying selectin-ligand interactions, critical for the pathogenesis of multifarious diseases, including cancer and inflammation. Alternative Names: Sialyl Lewisx-β-methyl glycoside; Neu5Ac-a-2-3-Gal-b-1-4[Fuc-a-1-3]GlcNAc-b-Ome; Methyl O-[5-acetamido-3,5-dideoxy-D-glycero-a-D-galacto-2-nonulopyranosylonic acid)-2-a-3-O-b-D-galactopyranosyl]-1-b-4-O-[(a-L-fucopyranosyl)-1-a-3]-2-acetamido-2-deoxy-b-D-glucopyranoside; Methyl 3-O-(alpha-L-fucopyranosyl)-4-O-[3-O-(N-acetyl-alpha-neuraminosyl)-beta-D-galactopyranosyl]-2-(acetylamino)-2-deoxy-beta-D-glucopyranoside; Methyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-β-D-glucopyranoside; Sialyl Lewisx-b-methyl glycoside. Grades: 98%. CAS No. 141612-87-5. Molecular formula: C32H54N2O23. Mole weight: 834.77. |  |
| Sialyl-Lex-hexa-APD-HSA | Sialyl-Lex-hexa-APD-HSA. | |
| Sialyl-LNF V-APD-HSA | Sialyl-LNF V-APD-HSA. | |
| Silver Sucrose Octasulfate | Silver Sucrose Octasulfate is a derivative of Sucrose Octasulfate, that is a nonpolymeric highly charged multivalent anionic trapping agent used in anticancer drug delivery of camptothecins. Other derivatives of Sucrose Octasulfate include Sucrose Octasulfate Potassium Salt, Sucrose Octasulfate Sodium Salt and Sucrose Octasulfate Ammonium Salt, which are used as reference standards for the drug Sucralfate. Alternative Names: α-D-Glucopyranoside, 1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl, 2,3,4,6-tetrakis(hydrogen sulfate), silver(1+) salt (1:8); α-D-Glucopyranoside, 1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl, tetrakis(hydrogen sulfate), octasilver(1+) salt; IASOS; Sucrosofate octasilver salt. CAS No. 517867-09-3. Molecular formula: C12H14Ag8O35S8. Mole weight: 1837.68. | |
| SIMA (HEX)-dT Phosphoramidite | SIMA (HEX)-dT Phosphoramidite embodies an exquisite chemical reagent, which, when employed in the synthesis of oligonucleotides, brings forth labeling with fluorescent prowess. This sky-high labeling capacity, what with its hexachlorofluorescein (HEX) dye and the thymidine base, can be ushered into diverse biomedical applications, including the fluoroescence in situ hybridization (FISH), DNA sequencing and detecting specific genetic mutations or diseases. Alternative Names: SIMA-dT phosphoramidite, 6-isomer; 5'-Dimethoxytrityl-5-[6-((2',7'-diphenyl-4,7-dichloro-3',6'-dipivaloylfluorescein-6-yl-carboxamido)-hexanoyl)-3-aminoallyl]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Grades: ≥95%. Molecular formula: C91H95Cl2N6O17P. Mole weight: 1646.64. | |
| Sinapinoyl L-arabinofuranoside | Sinapinoyl L-arabinofuranoside is a naturally occurring compound derived from diverse botanical sources with anticancer attributes. Molecular formula: C16H20O9. Mole weight: 356.33. | |
| Sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogenphosphate | Sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogenphosphate is a vital pharmaceutical drug, exhibiting multifaceted therapeutic application in studying a plethora of ailments like neoplastic disorders or viral affections. Alternative Names: Sodium 5'-O-(hydroxyphosphinato)uridine; Uridine 5'-monophosphate disodium salt. CAS No. 3106-18-1. Molecular formula: C9H12N2NaO9P. Mole weight: 346.16. | |
| Sodium (3aR,7S,9S,9aR)-2,2,7-Trimethylhexahydro-[1,3]dioxolo[4',5':5,6]pyrano[3,2-d][1,3]dioxin-9-yl Sulfate | Sodium (3aR,7S,9S,9aR)-2,2,7-Trimethylhexahydro-[1,3]dioxolo[4',5':5,6]pyrano[3,2-d][1,3]dioxin-9-yl Sulfate can be used an intermediate in the synthesis of D-Galactose-3-sulfate Potassium Salt. It is a sulfated conjugate of D-Galactose, an epimer of glucose which is found in milk and sugar beets as well as being synthesized by the body. Molecular formula: C11H17NaO9S. Mole weight: 348.30. | |
| Sodium-D-glucuronate hydrate | Sodium-D-glucuronate hydrate is an innovative compound proficiently employed in the research of osteoporosand hepatic disorders. It serves as an inherent forerunner in glycosaminoglycans synthesis. Alternative Names: D-Glucuronic acid sodium salt; D-Glucuronic acid sodium salt monohydrate. CAS No. 207300-70-7. Molecular formula: C6H11NaO8. Mole weight: 234.14. | |
| Sodium Retinoyl Hyaluronate (VCHA) | Sodium Retinoyl Hyaluronate (VCHA) is a skincare ingredient that synergizes the benefits of retinoic acid with hyaluronic acid. It enhances skin penetration, reduces the appearance of wrinkles, and promotes collagen production for anti-aging effects. Known for its low irritation and suitability for various skin types, VCHA improves skin texture, elasticity, and reduces the appearance of pores. It also has anti-acne, whitening and anti-inflammatory properties, making it an active ingredient in a range of cosmetic formulations targeting skin health and rejuvenation. Grades: ≥95%. | |
| Sofosbuvir 3',5'-Bis-(S)-phosphate | Sofosbuvir 3',5'-Bis-(S)-phosphate, an impurity of PSI-7977, which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Alternative Names: (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((R)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate. Grades: 98.77%. CAS No. 1337482-17-3. Molecular formula: C34H45FN4O13P2. Mole weight: 798.69. | |
| Sofosbuvir α-Isomer | As a derivative compound of Sofosbuvir, Sofosbuvir α-Isomer is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have shown PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Alternative Names: (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate. Molecular formula: C22H29FN3O9P. Mole weight: 529.45. | |
| Sofosbuvir Carboxylic Acid | As an impurity of Sofosbuvir, Sofosbuvir Carboxylic Acid is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Alternative Names: (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoic Acid. Molecular formula: C19H23FN3O9P. Mole weight: 487.37. | |
| Sofosbuvir Impurity 41 | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Alternative Names: N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-1-(1-methylethyl) Ester L-Alanine; O-Desphenyl Sofosbuvir. Grades: > 95%. CAS No. 1233335-82-4. Molecular formula: C16H25FN3O9P. Mole weight: 453.36. | |
| Solamargine and Solasonine (mixture) | Solamargine and Solasonine (mixture). Alternative Names: α-Solamargine mix. with α-Solasonine; (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside mix. with (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside. | |
| Sophorose | Sophorose, a remarkable carbohydrate compound of profound significance in the realm of biomedical industry, manifests its pivotal role in studying a plethora of ailments, encompassing the formidable adversaries of cancer, diabetes, and microbial infections. Alternative Names: D-Glucose, 2-O-β-D-glucopyranosyl-; 2-O-β-D-Glucopyranosyl-D-glucose; (2R,3S,4R,5R)-3,4,5,6-Tetrahydroxy-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. Grades: 95%. CAS No. 534-46-3. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| Sophorose monohydrate | Sophorose monohydrate, an abundantly present disaccharide, aids in studying metabolic disorders, diabetes mellitus, and cardiac pathologies. Alternative Names: D-Glucose, 2-O-β-D-glucopyranosyl-, monohydrate; Sophorose monohydrate; 2-O-β-D-Glucopyranosyl-D-glucose monohydrate; (2R,3S,4R,5R)-3,4,5,6-Tetrahydroxy-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal monohydrate. Grades: ≥95%. CAS No. 140686-17-5. Molecular formula: C12H22O11.H2O. Mole weight: 360.31. | |
| Sorbitan Monostearate (Span 60) | Sorbitan Monostearate is a sorbitan monoester that is used as an emulsifier to keep oils and water mixed. Alternative Names: Arlacel 60; Sorbitan stearate; Sorbitan, monooctadecanoate. CAS No. 1338-41-6. Molecular formula: C24H46O6. Mole weight: 430.62. | |
| Sp-2',3'-cAMPS | Sp-2',3'-cAMPS is a crucial cyclic nucleotide analog acting as an activator of protein kinase A (PKA), enabling the study of its role in signal transduction pathways. This product is widely used in biomedical field research to investigate the modulation of PKA activity and its implications in various drug responses and diseases involving cAMP-dependent signaling pathways. Alternative Names: Adenosine- 2', 3'- cyclic monophosphorothioate, exo / Sp- isomer, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 118276-00-9. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3. | |
| Sp-2-AEA-cAMPS | Sp-2-AEA-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and other markers. Alternative Names: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C12H18N7O5PS. Mole weight: 403.4. | |
| Sp-2-AEA-cAMPS-Agarose | Sp-2-AEA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Alternative Names: 2- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose. | |
| Sp-2'-AEC-cAMPS | Sp-2'-AEC-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and other markers. Alternative Names: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C13H18N7O6PS. Mole weight: 431.4. | |
| Sp-2'-AEC-cAMPS-Agarose | Sp-2'-AEC-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Alternative Names: 2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel. | |
| Sp-2-AHA-cAMPS | Sp-2-AHA-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and other markers. It is also a PDE-resistant analogue of 2-AHA-cAMP. Alternative Names: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 214276-94-5. Molecular formula: C16H26N7O5PS. Mole weight: 459.5. | |
| Sp-2-AHA-cAMPS-Agarose | Sp-2-AHA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Alternative Names: 2- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2'-AHC-cAMPS | Sp-2'-AHC-cAMPS is a PDE-stable analogue of cAMP used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Alternative Names: 2'- (6- Aminohexyl)carbamoyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. Molecular formula: C17H26N7O6PS. Mole weight: 487.5. | |
| Sp-2'-AHC-cAMPS-Agarose | Sp-2'-AHC-cAMPS-Agarose is the PDE-resistant protein kinase A activator Sp-cAMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Alternative Names: 2'- O- (6- Aminohexylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2'-AHC-cGMPS | Sp-2'-AHC-cGMPS is a PDE-stable cGMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. Alternative Names: 2'- (6- Aminohexyl)carbamoylguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 1262749-61-0. Molecular formula: C17H26N7O7PS. Mole weight: 503.5. | |
| Sp-2'-AHC-cGMPS-Agarose | Sp-2'-AHC-cGMPS-Agarose is the PDE-resistant PKG activator Sp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as some phosphodiesterases. Alternative Names: 2'- O- (6- Aminohexylcarbamoyl)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-2-CF3-cBIMPS | Sp-2-CF3-cBIMPS, a research chemical focused on insulin and glucose metabolism, has potential therapeutic benefits for metabolic diseases like diabetes. By activating the AMP-activated protein kinase (AMPK) pathway, it shows that adding a trifluoromethyl group can increase its potency compared to other AMPK activators. With its documented scientific profile, Sp-2-CF3-cBIMPS embodies a unique approach to metabolism research to inspire medical advancements. Alternative Names: 2- Trifluoromethyl- 1- β- D- ribofuranosylbenzimidazole- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Molecular formula: C13H11F3N2O5PS · Na. Mole weight: 418.3. | |
| Sp-2-Cl-cAMPS | Sp-2-Cl-cAMPS is an analogue of Sp-cAMPS, the protein kinase A stimulator. The chlorine atom in position 2 of adenine nucleobase significantly increase the stability and lipophilicity. Alternative Names: 2- Chloroadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 124854-63-3. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
| Sp-2'-O-MB-cAMPS | Sp-2'-O-MB-cAMPS is a precursor ofSp-cAMPS, a PDE-resistant stimulator of protein kinase A. Sp-cAMPS and butyrate are released after the metabolism of Sp-2'-O-MB-cAMPS by esterases. Compared to Sp-cAMPS, it has more lipophilic and membrane-permeant properties. Alternative Names: 2'- O- Monobutyryladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 152218-23-0. Molecular formula: C14H17N5O6PS · Na. Mole weight: 437.4. | |
| Sp-2'-O-Me-CTP-α-S | Sp-2'-O-Me-CTP-α-S is a CTP analogue that can be used for enzymatic introduction of phosphorothioate and modified 2'-OH groups into RNA. Alternative Names: 2'- O- Methylcytidine- 5'- O- (1- thiotriphosphate), Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143029-01-0. Molecular formula: C10H18N3O13P3S (free acid). Mole weight: 513.3 (free acid). | |
| Sp-2'-O-Me-GTP-α-S | Sp-2'-O-Me-GTP-α-S is an analogue of GTP that can be used for enzymatic introduction of phosphorothioate and modified 2'-OH groups into RNA. Alternative Names: 2'- O- Methylguanosine- 5'- O- (1- thiotriphosphate), Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 143029-02-1. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| Sp-5,6-DCl-cBIMPS | Sp-5,6-DCl-cBIMPS is a selective stimulator of cAMP- dependent protein kinases preferrring site B of type II isozyme. It is superior to dibutyryl cAMP or 8-CPT-cAMP in stability, membrane permeability and potency. Alternative Names: 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 120912-54-1. Molecular formula: C12H10Cl2N2O5PS · Na. Mole weight: 419.2. | |
| Sp-6-AE-cAMPS | Sp-6-AE-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It can be modified with fluorophores and other markers. Grades: ≥ 98% by HPLC. Molecular formula: C12H17N6O5PS. Mole weight: 388.4. | |
| Sp-6-AE-cAMPS-Agarose | Sp-6-AE-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
| Sp-6-AH-cAMPS | Sp-6-AH-cAMPS is a phosphodiesterase-resistant ligand in affinity chromatography of cAMP and cGMP binding proteins and can be modified with fluorophores and other markers. Grades: ≥ 98% by HPLC. Molecular formula: C16H25N6O5PS. Mole weight: 444.5. | |
| Sp-6-AH-cAMPS-Agarose | Sp-6-AH-cAMPS-Agarose is the Sp-cAMPS immobilized on agarose by an aminohexyl spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. | |
| Sp-6-Bnz-cAMPS | Sp-6-Bnz-cAMPS is a selective and PDE-resistant stimulator of cAMP-dependent protein kinase, which can be used as an Epac-negative control. Grades: ≥ 98% by HPLC. CAS No. 152218-18-3. Molecular formula: C17H15N5O6PS · Na. Mole weight: 471.4. | |
| Sp-6-Cl-cPuMPS | Sp-6-Cl-cPuMPS is a PDE-resistant activator of protein kinase A that can be modified in position 6. Alternative Names: 6- Chloropurine riboside- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 129693-12-5. Molecular formula: C10H9ClN4O5PS · Na. Mole weight: 386.7. | |
| Sp-6-Phe-cAMPS | Sp-6-Phe-cAMPS is a selective and PDE-resistant stimulator of protein kinase A, which is used as an Epac-negative control. Grades: ≥ 98% by HPLC. CAS No. 169335-92-6. Molecular formula: C16H15N5O5PS · Na. Mole weight: 443.4. | |
| Sp-8-AEA-cAMPS | Sp-8-AEA-cAMPS is a phosphodiesterase-resistant ligand for affinity chromatography of cAMP and cGMP binding proteins. It is often modified with fluorophores and other markers. Alternative Names: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 221904-84-3. Molecular formula: C12H18N7O5PS. Mole weight: 403.4. | |
| Sp-8-AEA-cAMPS-Agarose | Sp-8-AEA-cAMPS-Agarose is the protein kinase A activator Sp-cAMPS immobilized on agarose by an aminoethylamino spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Alternative Names: 8- (2- Aminoethylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel. | |
| Sp-8-AET-cGMPS | Sp-8-AET-cGMPS is a ligand in affinity chromatography and can be modified with fluorophores or other markers. Alternative Names: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 221904-92-3. Molecular formula: C12H17N6O6PS2. Mole weight: 436.4. | |
| Sp-8-AET-cGMPS-Agarose | Sp-8-AET-cGMPS-Agarose is the protein kinase G activator Sp-cGMPS immobilized on agarose by an aminoethylthio spacer, which can be used in affinity chromatography of cyclic nucleotide-responsive proteins such as protein kinases, phosphodiesterases and others. Alternative Names: 8- (2- Aminoethylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer; immobilized on agarose gel. | |
| Sp-8-AHA-cAMPS | Sp-8-AHA-cAMPS is a PDE-stable cAMP analogue used for immobilization as an affinity ligand or for coupling of labelling structures such as fluorophores. It is also a PDE-resistant analogue of 8-AHA-cAMP. Alternative Names: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 214272-03-4. Molecular formula: C16H26N7O5PS. Mole weight: 459.5. | |
| Sp-8-BnT-2'-O-Me-cAMPS / "S-223" | Sp-8-BnT-2'-O-Me-cAMPS is the most potent 2'-substituted activator of Epac2. In human osteosarcoma U2OS cell lines expressing Epac1 or Epac2, Sp-8-BnT-2'-O-Me-cAMPS does not induce Epac signalling at 100 μM possibly for inefficient cellular uptake in this biosystem. Alternative Names: 8- Benzylthio- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C18H19N5O5PS2 · Na. Mole weight: 503.5. | |
| Sp-8-Br-2'-O-Me-cAMPS | Sp-8-Br-2'-O-Me-cAMPS is a anti-hydrolytic form of 8-Br-2'-O-Me-cAMP, a specific membrane-permeant stimulator of the exchange protein activated by cAMP (Epac) or cAMP-GEF. Alternative Names: 8- Bromo- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 634208-34-7. Molecular formula: C11H12BrN5O5PS · Na. Mole weight: 460.2. | |
| Sp-8-Br-cAMPS | Sp-8-Br-cAMPS is a resistant activator of protein kinase A, the cAMP agonist. Compared to Sp-cAMPS, it has more lipophilic and membrane-permeant properties. Alternative Names: 8- Bromoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 127634-20-2. Molecular formula: C10H10BrN5O5PS · Na. Mole weight: 446.2. | |
| Sp-8-Br-cAMPS-AM | Sp-8-Br-cAMPS-AM is a PDE-resistant precursor of Sp-8-Br-cAMPS, the protein kinase A stimulator. The active analogue is released after the metabolism of Sp-8-Br-cAMPS-AM by esterases. Alternative Names: 8- Bromoadenosine- 3', 5'- monophosphorothioate, acetoxymethyl ester, Sp- isomer ( Sp-8-Br-cAMPS-AM ). Grades: ≥ 97% by HPLC for mixture of the axial and equatorial isomer. Molecular formula: C13H15BrN5O7PS. Mole weight: 496.2. | |
| Sp-8-Br-cGMPS | Sp-8-Br-cGMPS is an activator of protein kinase G I α and protein kinase A. It has a resistant effect against cyclic nucleotide phosphodiesterases. Compared to cGMP or Sp-cGMPS, it has more lipophilic and membrane-permeant properties. Alternative Names: 8- Bromoguanosine- 3', 5'- monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 153660-03-8. Molecular formula: C10H10BrN5O6PS · Na. Mole weight: 462.2. | |
| Sp-8-Br-PET-cGMPS | Sp-8-Br-PET-cGMPS is an inhibitor of the retinal type cGMP-gated ion channel (cGMP antagonist) as well as a stimulator of cyclic GMP-dependent protein kinase I α and I ß (cGMP agonist), which is used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Alternative Names: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-21-2. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
| Sp-8-Cl-cAMPS | Sp-8-Cl-cAMPS is a resistant stimulator of protein kinase A, the cAMP agonist. Compared with 8-Cl-cAMP, it has the increased lipophilic and membrane-permeant properties. Alternative Names: 8- Chloroadenosine- 3', 5'- monophosphorothioate, Sp- isomer. Grades: ≥ 99% by HPLC. CAS No. 142754-28-7. Molecular formula: C10H10ClN5O5PS · Na. Mole weight: 401.7. | |
| Sp-8-CPT-cAMPS | Sp-8-CPT-cAMPS is a selective activator of protein kinase A (cAMP agonist). It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Alternative Names: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 129693-13-6. Molecular formula: C16H14ClN5O5PS2 · Na. Mole weight: 509.8. | |
| Sp-8-OH-cAMPS | Sp-8-OH-cAMPS is a polar analogue of Sp-cAMPS, the protein kinase A activator, with an antagonistic effect of mammalian cyclic nucleotide-dependent phosphodiesterases. It can be used for the study of extracellular cAMP receptors. Alternative Names: 8- Hydroxyadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 749843-87-6. Molecular formula: C10H11N5O6PS · Na. Mole weight: 383.3. | |
| Sp-8-pCPT-2'-O-Me-cAMPS | Sp-8-pCPT-2'-O-Me-cAMPS is an activator of the exchange protein activated by cAMP (Epac) or cAMP-GEF, which is inactive for protein kinase A. It is much more lipophilic and membrane permeant. Alternative Names: 8- (4- Chlorophenylthio)- 2'- O- methyladenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 634208-37-0. Molecular formula: C17H16ClN5O5PS2 · Na. Mole weight: 523.9. | |
| Sp-8-pCPT-cGMPS | Sp-8-pCPT-cGMPS is a stimulator of protein kinase G type I α and type II with superior membrane permeability and stability. Uses: Enzyme inhibitors. Alternative Names: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 160385-87-5. Molecular formula: C16H14ClN5O6PS2 · Na. Mole weight: 525.9. | |
| Sp-8-pCPT-PET-cGMPS | Sp-8-pCPT-PET-cGMPS is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Sp-8-Br-PET-cGMPS, Sp-8-pCPT-PET-cGMPS is much more lipophilic and membrane-permeant. Alternative Names: 8- (4- Chlorophenylthio)-β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 1262749-63-2. Molecular formula: C24H18ClN5O6PS2 · Na. Mole weight: 626. | |
| Sp-8-PIP-cAMPS | Sp-8-PIP-cAMPS is a selective cAMP analogue with a preference for site B of protein kinase A type II. Alternative Names: 8- Piperidinoadenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 156816-35-2. Molecular formula: C15H20N6O5PS · Na. Mole weight: 450.4. | |
| Spacer C12 CE Phosphoramidite | Spacer phosphoramidites C3, 9, and 18 are used to insert spacer arms in oligonucleotides. When a longer spacer is required, the compound can be added multiple times. Alternative Names: SPACER-C12 CEP; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 12-[bis(4-methoxyphenyl)phenylmethoxy]dodecyl 2-cyanoethyl ester; 12-(4,4'-Dimethoxytrityloxy)dodecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 12-(Bis(4-methoxyphenyl)(phenyl)methoxy)dodecyl(2-cyanoethyl)diisopropyl phosphoramidite; Spacer Phosphoramidite C12; Spacer-C12 Phosphoramidite; Spacer C12 CEP hosphoramidite; C12 Spacer Amidite. Grades: >95% by HPLC. CAS No. 158665-27-1. Molecular formula: C42H61N2O5P. Mole weight: 704.93. | |
| Spacer C6 CE Phosphoramidite | Spacer C6 CE Phosphoramidite is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required. Molecular formula: C36H49N2O5P. Mole weight: 620.77. | |
| Sp-cAMPS-AM | Sp-cAMPS-AM is a precursor of Sp-cAMPS, the PDE-resistant protein kinase A stimulator. Sp-cAMPS is released after metabolism of Sp-cAMPS-AM by esterases. Alternative Names: Adenosine- 3', 5'- monophosphorothioate acetoxymethyl ester, Sp- isomer. Grades: ≥ 97% by HPLC for mixture of the axial and equatorial isomer. CAS No. 152218-24-1. Molecular formula: C13H16N5O7PS. Mole weight: 417.3. | |
| Sp-cAMPS, sodium salt | Sp-cAMPS is an activator of protein kinase A (cAMP agonist). It exhibits high resistance against cyclic nucleotide phosphodiesterases and membrane permeability in organisms. Uses: Protein kinase inhibitors. Alternative Names: Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 71774-13-5. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3. | |
| Sp-cAMPS, triethyl ammonium salt | Sp-cAMPS is a stimulator of protein kinase A, the cAMP agonist. It has higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP and membrane permeability comparable to 8-Br-cAMP. Alternative Names: Adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, triethyl ammonium salt. Grades: ≥ 98% by HPLC. CAS No. 93602-66-5. Molecular formula: C10H11N5O5PS · C6H16N. Mole weight: 446.5. | |
| Sp-cCMPS | Sp-cCMPS is a PDE-resistant cCMP, the potential second messenger, which may activate cCMP-binding proteins. Alternative Names: Cytidine- 3', 5'- cyclic monophosphorothioate, Sp- isomer. Grades: ≥ 98% by HPLC. CAS No. 87063-81-8. Molecular formula: C9H11N3O6PS · Na. Mole weight: 343.2. | |
| Sp-c-diAMPS | Sp-c-diAMPS is an analogue of c-diAMP, the bacterial second messenger. Alternative Names: Cyclic diadenosine monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2S (free acid). Mole weight: 674.5 (free acid). | |
| Sp-c-diGMPS | Sp-c-diGMPS is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Alternative Names: Cyclic diguanosine monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1259875-39-2. Molecular formula: C20H24N10O13P2S (free acid). Mole weight: 706.5 (free acid). | |
| Sp-cGMPS | Sp-cGMPS is a resistant stimulator of cGMP-dependent protein kinases. Alternative Names: Guanosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 86562-10-9. Molecular formula: C10H11N5O6PS · Na. Mole weight: 383.3. | |
| Spermine CE Phosphoramidite | Spermine CE Phosphoramidite. Molecular formula: C56H73F12N6O9P. Mole weight: 1233.19. | |
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