BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| EPZ004777 | EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL. Uses: Reprogramming. Synonyms: EPZ004777; EPZ 004777; EPZ-004777. Grade: 0.98. CAS No. 1338466-77-5. Molecular formula: C28H41N7O4. Mole weight: 539.681. |  |
| EPZ004777 hydrochloride | EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. EPZ004777 selectively inhibits proliferation of MLL-AF10 and CALM-AF10-transformed murine bone marrow cells. DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. Synonyms: EPZ 004777 hydrochloride; EPZ-004777 hydrochloride; EPZ004777 hydrochloride. Grade: >98%. CAS No. 1380316-03-9. Molecular formula: C28H42ClN7O4. Mole weight: 576.13. | |
| EPZ005687 | EPZ005687 is a selective EZH2 enzyme inhibitor with Ki of 24 nM. It is 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. EPZ005687 can block trimethylation of the PRC2 target histone 3 lysine 27 with IC50 value of 80 nM, decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2. No development of preclinical research for the treatment of Cancer, Lymphoma and Solid tumours was reported. Uses: Cancer; lymphoma; solid tumours. Synonyms: EPZ005687; EPZ 005687; EPZ-005687; 1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide; 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide. Grade: 98%. CAS No. 1396772-26-1. Molecular formula: C32H37N5O3. Mole weight: 539.67. | |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. Synonyms: EPZ011989; EPZ-011989; EPZ 011989. Grade: 98%. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. | |
| EPZ011989 trifluoroacetate | EPZ011989 trifluoroacetate is the trifluoroacetate salt form of EPZ011989. EPZ011989 is a potent and orally bioavailable inhibitor that specifically targets the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2), with significant tumor growth in. Synonyms: EPZ011989 TFA salt; EPZ011989 TFA; EPZ 011989 TFA; EPZ-011989 TFA; N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl(methyl)amino]cyclohexyl]amino]-2-methyl-5-(3-morpholin-4-ylprop-1-ynyl)benzamide; 2,2,2-trifluoroacetic acidEPZ011989 (trifluoroacetate). CAS No. 1598383-41-5. Molecular formula: C37H52F3N5O6. Mole weight: 719.83. | |
| EPZ015666 | EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. Synonyms: EPZ015666; EPZ-015666; EPZ 015666; GSK3235025; GSK-3235025; GSK 3235025. Grade: >98%. CAS No. 1616391-65-1. Molecular formula: C20H25N5O3. Mole weight: 383.44. | |
| EPZ015866 | EPZ015866,also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati. Synonyms: GSK591; GSK-591; GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591; 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamideEPZ015866GSK591GTPL8954SCHEMBL16220740GSK32035912-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carbo. CAS No. 1616391-87-7. Molecular formula: C22H28N4O2. Mole weight: 380.48. | |
| EPZ020411 | EPZ020411, with potent anticancer activity, is an orally bioactive, selective inhibitor of PRMT6/8/1 with over 100-fold selective for other histone methyltransferases including four arginine methyltransferases (PRMT3, PRMT4, PRMT5, and PRMT7). Synonyms: N,N'-dimethyl-N'-[[5-[4-[3-[2-(oxan-4-yl)ethoxy]cyclobutyl]oxyphenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamineEPZ020411; EPZ 020411; EPZ-020411CHEMBL3589039GTPL9243SCHEMBL1762195749LN,N'-Dimethyl-N-({3-[4-({trans-3-[2-(Tetrahydro-2h-Pyran-4-Yl)ethoxy]cyclobutyl}oxy)phenyl. CAS No. 1700663-41-7. Molecular formula: C25H38N4O3. Mole weight: 442.59. | |
| EPZ020411 HCl | EPZ020411 hydrochloride is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM, and it displays >10-fold and 20-fold selectivity over PRMT1/8. Synonyms: EPZ-020411 hydrochloride. Grade: ≥97%. CAS No. 2070015-25-5. Molecular formula: C25H39ClN4O3. Mole weight: 479.06. | |
| EPZ-5676 | EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes. This eventually leads to an induction of apoptosis in the leukemic cells bearing the MLL gene translocations. DOT1L, a non-SET domain-containing histone methyltransferase, specifically methylates H3K79 and plays a key role in normal cell differentiation and in the development of leukemia with MLL gene rearrangement on chromosome 11 and promotes the expression of leukemia-causing genes. Synonyms: EPZ-5676; EPZ5676; EPZ 5676. CAS No. 1380288-87-8. Molecular formula: C30H42N8O3. Mole weight: 562.719. | |
| EPZ-6438 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. Synonyms: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat. Grade: 98%. CAS No. 1403254-99-8. Molecular formula: C34H44N4O4. Mole weight: 572.75. | |
| Equilenin | Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one; (+)-Equilenin; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one. Grade: > 95%. CAS No. 517-09-9. Molecular formula: C18H18O2. Mole weight: 266.34. | |
| Equilenin Sulfate Sodium | A metabolite of Equilin. Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-(Sulfooxy)-estra-1,3,5,7,9-pentaen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one HydrogenSulfate Monosodium Salt. Grade: > 95%. CAS No. 16680-48-1. Molecular formula: C18H17FO5S Na. Mole weight: 345.40 22.99. | |
| Equilin | Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Uses: An estrogen. Synonyms: 3-Hydroxy-13-methyl-9,11,12,14,15,16-hexahydro-6H-cylcopenta(a)phenanthren-17-one. Grade: > 95%. CAS No. 474-86-2. Molecular formula: C18H20O2. Mole weight: 268.36. | |
| Equilin 3-Benzoate | Equilin 3-Benzoate is an intermediate of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 3-(Benzoyloxy)-estra-1,3,5(10),7-tetraen-17-one; 3-Hydroxy-estra-1,3,5(10),7-tetraen-17-one Benzoate; Equilin benzoate; 17-Oxoestra-1,3,5(10),7-tetraen-3-yl benzoate; Estra-1,3,5(10),7-tetraen-17-one, 3-(benzoyloxy)-; Equilin Impurity 10. Grade: ≥95%. CAS No. 6030-80-4. Molecular formula: C25H24O3. Mole weight: 372.46. | |
| Equilin 3-O-β-D-glucuronide | An impurity of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-glucopyranosiduronic acid. CAS No. 76663-60-0. Molecular formula: C24H28O8. Mole weight: 444.47. | |
| Equilin 3-O-beta-D-Glucuronide Sodium Salt | A derivative of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-Glucopyranosiduronic Acid Monosodium Salt. Grade: > 95%. CAS No. 27610-12-4. Molecular formula: C24H27O8.Na. Mole weight: 466.46. | |
| Equilin 3-Sulfate Sodium Salt | A derivative of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Uses: Estrogens. Synonyms: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one Hydrogen Sulfate Sodium Salt; Sodium Equilin 3-Monosulfate. Grade: > 95%. CAS No. 16680-47-0. Molecular formula: C18H19O5S. Na. Mole weight: 370.4. | |
| Equilin-d4 3-beta-O-D-Glucuronide Sodium Salt | One of the isotope labelled derivative of Equilin, which is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-Glucopyranosiduronic Acid Monosodium Salt-d4. Molecular formula: C24H23O8D4.Na. Mole weight: 470.49. | |
| Equilin Sulfate | Equilin Sulfate is a metabolite of Equilin, which is an estrogen, or an agonist of the estrogen receptors ERα and ERβ. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl hydrogen sulfate; Estra-1,3,5(10),7-tetraen-17-one, 3-(sulfooxy)-; [(9S,13S,14S)-17-keto-13-methyl-9,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate. Grade: 95%. CAS No. 27540-07-4. Molecular formula: C18H20O5S. Mole weight: 348.41. | |
| ER-000444793 | ER-000444793, a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening, inhibits mPTP with an IC50 of 2.8?μM. R-000444793 neither affected cyclophilin D (CypD) enzymatic activity, nor displaced of CsA from CypD protein, suggesting a mechanism independent of CypD inhibition. Synonyms: N-(2-benzylphenyl)-2-oxo-1H-quinoline-4-carboxamide; ER-000444793; ER 000444793; ER000444793. CAS No. 792957-74-5. Molecular formula: C23H18N2O2. Mole weight: 354.4. | |
| ER 27319 | ER 27319 is a selective PLK-1 and Syk kinase inhibitor. Synonyms: 9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, ethanedioate (1:1); 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone ethanedioate (1:1); 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone Oxalate; ER27319; ER-27319; 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate; ER 27319 Oxalate. Grade: ≥95%. CAS No. 201010-95-9. Molecular formula: C18H20N2O.C2H2O4. Mole weight: 370.40. | |
| ER 27319 maleate | ER 27319 maleate is a selective Syk kinase inhibitor. It suppresses tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells, causing the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. Synonyms: ER27319 maleate; ER-27319 maleate; 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate; 9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1); 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone maleate. Grade: ≥99% by HPLC. CAS No. 1204480-26-1. Molecular formula: C18H20N2O.C4H4O4. Mole weight: 396.17. | |
| ER 50891 | ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM). Synonyms: ER 50891; ER50891; ER-50891; 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid. Grade: ≥99% by HPLC. CAS No. 187400-85-7. Molecular formula: C29H24N2O2. Mole weight: 432.51. | |
| ER-67880 | ER-67880 is a novel and potent microtubule inhibitor with potential anticancer activity. Synonyms: ER 67880; ER67880; N-(3-chloro-1H-indol-7-yl)-4-methoxy-benzenesulfonamide. Grade: 98%. CAS No. 247186-96-5. Molecular formula: C15H13ClN2O3S. Mole weight: 336.79. | |
| ER-805751 | ER-805751 is a potent proteasome inhibitor. Synonyms: ER-80575; ER805751; ER 805751. Grade: 98%. CAS No. 565454-88-8. Molecular formula: C25H30N2O6. Mole weight: 454.52. | |
| ER 819762 | ER 819762 is a potent and selective EP4 receptor antagonist (IC50 = 59 nM) that inhibits EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. It was shown to suppress Th1 and Th17 cytokine production, collagen- and GPI-induced arthritis in mice. It attenuates CFA-induced inflammatory pain in rats. Uses: Analgesic. Synonyms: ER819762; ER 819762; ER-819762. (10S)-1'-[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one. Grade: ≥98% by HPLC. CAS No. 1155773-15-1. Molecular formula: C30H39N3O3. Mole weight: 489.65. | |
| ERA63 | A selective agonist of estrogen receptor α. Synonyms: ERA63; ERA 63; ERA-63; (7R,8R,9S,13S,14S,17R)-17-ethynyl-7,13-dimethyl-3-methylidene-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol. CAS No. 343248-86-2. Molecular formula: C22H30O. Mole weight: 310.47. | |
| Eragidomide | Eragidomide is a modulator of the E3 ligase cereblon and has antineoplastic activity. Synonyms: rac-2-(4-chlorophenyl)-N-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide; CC-90009; Cereblon modulator 1; NSC828250; CC 90009; CC90009; 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-benzeneacetamide. Grade: ≥98% by HPLC. CAS No. 1860875-51-9. Molecular formula: C22H18ClF2N3O4. Mole weight: 461.85. | |
| ERα degrader-2 | ERα degrader-2, a selective estrogen receptor degrader (SERD), has a strong binding affinity with ERα (IC50 = 17.1 nM) and a good degradation efficacy (EC50 = 0.3 nM). It has good pharmacokinetic properties and druggability, and can be used in the study of HER+ breast cancer. Synonyms: [1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-. CAS No. 2235396-63-9. Molecular formula: C29H27F3N2O2. Mole weight: 492.53. | |
| ERAP1-IN-1 | ERAP1-IN-1 is an inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme that trims peptides loaded into classical and nonclassical MHC Class I molecules. Synonyms: ERAP1 inhibitor compound 3; 4-Methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid. Grade: 99%. CAS No. 865273-97-8. Molecular formula: C20H21F3N2O5S. Mole weight: 458.45. | |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Synonyms: Erastin. Grade: 0.98. CAS No. 571203-78-6. Molecular formula: C30H31ClN4O4. Mole weight: 547.04454. | |
| Erastin2 | Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter, which inhibits glutamate release in CCF-STTG1 cells with an IC50 of 0.0035 μM. Synonyms: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone. Grade: ≥98%. CAS No. 1695533-44-8. Molecular formula: C36H35ClN4O4. Mole weight: 623.14. | |
| Eravacycline dihydrochloride | Eravacycline, a novel fluorocycline previously known as TP-434, in virto has broad-spectrum activity against both Gram-positive and Gram-negative aerobic and anaerobic pathogens including important antimicrobial resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and extended-spectrum ?-lactamase (ESBL)-producing and carbapenemaseproducing Enterobacteriaceae and multidrug-resistant Acinetobacter baumannii. Synonyms: (4S,4aS,5aR,12aR)-4-(dimethylamino)-7-fluoro-1,10,11,12a-tetrahydroxy-3,12-dioxo-9-[(2-pyrrolidin-1-ylacetyl)amino]-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide; dihydrochloride; Eravacycline (dihydrochloride). CAS No. 1334714-66-7. Molecular formula: C27H33Cl2FN4O8. Mole weight: 631.48. | |
| ERB-041 | ERB 041 is a highly selective agonist of the ERβ subtype of the estrogen receptor, displays >200-fold selectivity for ERβ over Erα. Uses: Potent erβ agonist. Synonyms: Prinaberel; 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol; ERB041; ERB 041; ERB041; Prinaberel; WAY-202041; WAY202041; WAY 202041 (4Z)-4-(7-ethenyl-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)-2-fluorocyclohexa-2,5-dien-1-one. Grade: ≥98%. CAS No. 524684-52-4. Molecular formula: C15H10FNO3. Mole weight: 271.24. | |
| ERB-196 | ERB-196 is a nonsteroidal selective agonist of estrogen receptor-β (ERβ). Synonyms: WAY-202196; 1-Naphthalenecarbonitrile, 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxy-; 3-(3-Fluoro-4-hydroxyphenyl)-7-hydroxy-1-naphthonitrile. Grade: ≥95%. CAS No. 550997-55-2. Molecular formula: C17H10FNO2. Mole weight: 279.27. | |
| Ercalcitriol | Ercalcitriol is an active metabolite of vitamin D2. It exhibits equipotent antirachitic activity in rats as calcitriol. Synonyms: RO-17-6218; RO 17-6218; RO17-6218; 1α,25-Dihydroxy Vitamin D2; 1,25-Dihydroxycalciferol; 1alpha,25-Dihydroxyvitamin D2; 1,25-Dihydroxyergocalciferol. Grade: >98%. CAS No. 60133-18-8. Molecular formula: C28H44O3. Mole weight: 428.65. | |
| Erdafitinib | Erdafitinib, also known as JNJ-42756493, is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Synonyms: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib. Grade: 98%. CAS No. 1346242-81-6. Molecular formula: C25H30N6O2. Mole weight: 446.55. | |
| Erdosteine | Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus. Synonyms: Erdosteine; PV 144; PV144; PV-144; RV 144; RV144; RV-144. Grade: >98%. CAS No. 84611-23-4. Molecular formula: C8H11NO4S2. Mole weight: 249.31. | |
| Erdosteine Homocysteine Impurity (Erdosteine RV201) | Erdosteine Homocysteine Impurity (Erdosteine RV201) is an impurity of the mucolytic Erdosteine. Synonyms: 2-[N-3-[2-(Oxotetrahydro)thienyl]acetimido]-N-(carboxymethylthioacetyl)homcysteine; [2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetyl]homocysteine; Erdosteine RV 201; N-[({2-Oxo-2-[(2-oxotetrahydro-3-thiophenyl)amino]ethyl}sulfanyl)acetyl]homocysteine; (2-((2-oxo-2-((2-oxotetrahydrothiophen-3-yl)amino)ethyl)thio)acetyl)homocysteine; Homocysteine, N-[2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetyl]-. Molecular formula: C12H18N2O5S3. Mole weight: 366.48. | |
| Erdosteine thioacid | Erdosteine Thioacid is the active metabolite of Erdosteine, which is a mucolytic used in the treatment of excessive viscous mucus. Synonyms: N-[[(Carboxymethyl)thio]acetyl]homocysteine; [[2-Oxo-2-[(1-carboxy-3-mercaptopropyl)amino]ethyl]thio]acetic acid; Erdosteine Metabolite 1; Butanoic acid, 2-((((carboxymethyl)thio)acetyl)amino)-4-mercapto-, DL-; DL-2-((((Carboxymethyl)thio)acetyl)amino)-4-mercaptobutanoic acid; Homocysteine, N-[[(carboxymethyl)thio]acetyl]-. Grade: ≥95%. CAS No. 121213-21-6. Molecular formula: C8H13NO5S2. Mole weight: 267.32. | |
| Erdosteine Thioacid Diammonium Salt | Erdosteine Thioacid Diammonium Salt is the active metabolite of Erdosteine. Erdosteine is a mucolytic. Synonyms: N-[[(Carboxymethyl)thio]acetyl]homocysteine Diammonium Salt. Grade: 95%. Molecular formula: C8H19N3O5S2. Mole weight: 301.38. | |
| Erdosteine Thioacid Disodium Salt | Erdosteine Thioacid Disodium Salt is the active metabolite of Erdosteine, which is a mucolytic used in the treatment of excessive viscous mucus. Synonyms: N-[[(Carboxymethyl)thio]acetyl]homocysteine Disodium Salt; [[2-Oxo-2-[(1-carboxy-3-mercaptopropyl)amino]ethyl]thio]acetic acid Disodium Salt; Erdosteine Metabolite 1 Disodium Salt; Butanoic acid, 2-((((carboxymethyl)thio)acetyl)amino)-4-mercapto-, DL-, sodium salt (1:2); DL-2-((((Carboxymethyl)thio)acetyl)amino)-4-mercaptobutanoic acid Disodium Salt. Grade: 96%. CAS No. 254884-18-9. Molecular formula: C8H11NNa2O5S2. Mole weight: 311.29. | |
| ERDRP-0519 | ERDRP-0519 is a pan-morbillivirus inhibitor for the treatment of measles. It acts via targeting the morbillivirus RNA-dependent RNA-polymerase (RdRP) complex and displaying unparalleled oral efficacy against lethal infection of ferrets with CDV, an established surrogate model for human measles. Synonyms: 1-Methyl-N-[4-[[(2S)-2-[2-(4-morpholinyl)ethyl]-1-piperidinyl]sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide. Grade: >98%. CAS No. 1374006-96-8. Molecular formula: C23H30F3N5O4S. Mole weight: 529.6. | |
| Erenumab | Erenumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Erenumab has been used for the preventive treatment of migraines. Synonyms: Aimovig. CAS No. 1582205-90-0. | |
| E-Retinyl b-glucuronide | E-Retinyl b-glucuronide is a biomedical compound, used for studying retinal diseases. Derived from retinol, this compound is indispensable in preserving visual acuity and upholding retinal well-being. Synonyms: all-trans-Retinyl b-glucuronide. CAS No. 16639-19-3. Molecular formula: C26H38O7. Mole weight: 462.58. | |
| ERGi-USU | ERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM) which displays >6-fold selectivity for RIOK2 over a panel of 456 kinases. Synonyms: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol; 1-(1,3-thiazol-2-yldiazenyl)naphthalen-2-ol. Grade: ≥99% by HPLC. CAS No. 1147-56-4. Molecular formula: C13H9N3OS. Mole weight: 255.3. | |
| Ergocalciferol EP Impurity A | Ergocalciferol EP Impurity A is an isomer of vitamin D2. Vitamin D2 is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Synonyms: Vitamin D2 EP Impurity A; 5,6-trans-Vitamin D2; trans-Vitamin D2; (3E)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol. CAS No. 51744-66-2. Molecular formula: C28H44O. Mole weight: 396.65. | |
| Ergocalciferol EP Impurity C | Lumisterol is an impurity of vitamin D2 of steroid compounds. It is produced in the preparation of vitamin D1. Uses: Provitamins. Synonyms: Lumisterol; (22E)-9β,10α-ergosta-5,7,22-trien-3β-ol; 9-beta,10-alpha-Ergosta-5,7,22-trien-3-beta-ol. CAS No. 474-69-1. Molecular formula: C28H44O. Mole weight: 396.65. | |
| Ergocalciferol EP Impurity D | Isotachysterol is an impurity of vitamin D2, which is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Synonyms: Isotachysterol; isotachysterol2; (3S,6E,22E)-9,10-Secoergosta-5(10),6,8(14),22-tetraen-3-ol; 6E-9,10-Secoergosta-5(10),6,8(14),22E-tetraen-3beta-ol. CAS No. 469-06-7. Molecular formula: C28H44O. Mole weight: 396.65. | |
| Ergocalciferol EP Impurity E | Tachysterol is an impurity of vitamin D2, which is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Synonyms: Tachysterol; Tachysterol2; (3S,6E,22E)-9,10-secoergosta-5(10),6,8,22-tetraen-3-ol. CAS No. 115-61-7. Molecular formula: C28H44O. Mole weight: 396.65. | |
| Ergocalciferol EP Impurity F | Ergocalciferol EP Impurity F is an impurity of vitamin D2, which is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Synonyms: (3S,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22,24(241)-pentaen-3-ol. Molecular formula: C28H42O. Mole weight: 394.65. | |
| Ergocalciferol Glucuronide | One of the derivatives of Vitamin D2, which has been found to be effective as an antirachitic agent. Molecular formula: C34H52O7. Mole weight: 572.79. | |
| Ergocalciferol Impurity 2 | Ergocalciferol Impurity 2 is an impurity of vitamin D2, which is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Molecular formula: C28H42O. Mole weight: 394.65. | |
| Ergocalciferol Sulfate | One of the derivatives of Vitamin D2, which has been found to be effective as an antirachitic agent. Synonyms: (3β,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Hydrogen Sulfate; Ergocalciferol Hydrogen Sulfate; Vitamin D2 3β-Sulfate; Vitamin D2 Sulfate. Molecular formula: C28H44O4S. Mole weight: 476.72. | |
| Eribaxaban | Eribaxaban is an orally active inhibitor of coagulation factor Xa (activated factor X). It has anticoagulant activity and is used as an anticoagulant drug. It is used for the treatment and prevention of thrombotic disorders. It inhibited arterial thrombosis comparable to aspirin plus clopidogrel. It was developed by Pfizer. It was in phase II clinical trials, but has been terminated. Uses: Eribaxaban has anticoagulant activity and is used as an anticoagulant drug. it is used for the treatment and prevention of thrombotic disorders. Synonyms: PD348292; PD-348292; PD 348292; PD0348292; PD-0348292; PD 0348292; PD348,292; PD-348,292; PD 348,292; Eribaxaban; (2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide. Grade: 98%. CAS No. 536748-46-6. Molecular formula: C24H22ClFN4O4. Mole weight: 484.91. | |
| Eriodictyol chalcone | Eriodictyol chalcone possesses both anti-aromatase and anti-17β-HSD activity. Synonyms: 2',3,4,4',6'-Pentahydroxychalcone; 3,4,2',4',6'-Pentahydroxychalcone. CAS No. 14917-41-0. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Eritadenine Acetonide | Eritadenine Acetonide is an intermediate in the synthesis of Eritadenine, which is an inhibitor of S-adenosine-L-homocysteine hydrolase (SAHH) with hypocholesterolemic activity. Synonyms: (4R-cis)-5-[(6-Amino-9H-purin-9-yl)methyl]-2,2-dimethyl-1,3-dioxolane-4-carboxylic Acid; D-4-(6-Amino-9H-purin-9-yl)-4-deoxy-2,3-O-isopropylidene-erythronic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-2,3-O-isopropylidene-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-2,3-O-isopropylidene-D-erythronic Acid; 1,3-Dioxolane-4-carboxylic acid, 5-[(6-amino-9H-purin-9-yl)methyl]-2,2-dimethyl-, (4R-cis)-. CAS No. 29031-25-2. Molecular formula: C12H15N5O4. Mole weight: 293.28. | |
| Eritoran | Eritoran is a TLR4 antagonist that is developed for the treatment of severe sepsis. Synonyms: ERITORAN; 185955-34-4; Eritoran [INN]; E5564; CHEMBL501259; [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] dihydrogen phosphate; CHEBI:68609; 551541VI0Y; 3-O-decyl-2-deoxy-6-O-(2-deoxy-3-O-(3-methoxydecyl)-6-O-methyl-2-((1-oxo-11-octadecenyl. Grade: 95%. CAS No. 185955-34-4. Molecular formula: C66H126N2O19P2. Mole weight: 1313.66. | |
| ERK1/2 inhibitor 1 | ERK1/2 inhibitor 1 is a potent and orally bioavailable ERK1/2 inhibitor, inhibiting ERK1 up to 60% at 1 nM and inhibiting ERK2 with an IC50 of 3.0 nM. Synonyms: 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-; (2R)-2-{6-[5-Chloro-2-(tetrahydro-2H-pyran-4-ylamino)-4-pyrimidinyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]propanamide. Grade: ≥95%. CAS No. 2095719-90-5. Molecular formula: C29H32ClN5O4. Mole weight: 550.05. | |
| ERK1/2 inhibitor 3 | ERK1/2 inhibitor 3, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021218912A1, compound 1). Synonyms: (S)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2737294-99-2. Molecular formula: C28H31ClFN5O6S. Mole weight: 620.09. | |
| ERK1/2 inhibitor 4 | ERK1/2 inhibitor 5, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2020238776A1). Synonyms: Thieno[3,2-c]pyridine-5(4H)-acetamide, 2-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-6,7-dihydro-α-methyl-4-oxo-, (αR)-. CAS No. 2490396-99-9. Molecular formula: C28H31ClFN5O5S. Mole weight: 604.09. | |
| ERK1/2 inhibitor 6 | ERK1/2 inhibitor 6, a potent ERK1/2 inhibitor, has the potential to study or prevent cancer, inflammation, or other proliferative diseases. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of MAPK family. (Extracted from patent WO2021063335A1, compound 1). Synonyms: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-4-oxopyrrolo[2,1-f][1,2,4]triazin-3(4H)-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide. CAS No. 2634816-13-8. Molecular formula: C27H29ClFN7O5. Mole weight: 586.01. | |
| ERK2 IN-1 | ERK2 IN-1 is a selective inhibitor of ERK2 with an IC50 of 7 nM. Synonyms: (3S)-N-[3-(4-Fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(2-pyrimidinyl)phenyl]-3,6-dihydro-1(2H)-pyridinyl}ethyl)-3-pyrrolidinecarboxamide; 3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(2-pyrimidinyl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylthio)-, (3S)-. Grade: ≥95%. CAS No. 1093061-47-2. Molecular formula: C36H34FN7O2S. Mole weight: 647.76. | |
| ERK5-IN-2 | ERK5-IN-2 is a submicromolar selective ERK5 inhibitor with oral activity, which can inhibit tumor xenograft growth and basic fibroblast growth factor (bFGF)-driven Matrigel plug angiogenesis. Synonyms: 4-(2-Bromanyl-6-Fluoranyl-Phenyl)Carbonyl-{N}-Pyridin-3-Yl-1{H}-Pyrrole-2-Carboxamide; SCHEMBL17607180; BCP32587; EX-A4938. Grade: 98%. CAS No. 1888305-96-1. Molecular formula: C17H11BrFN3O2. Mole weight: 388.2. | |
| ERK-IN-2 | ERK-IN-2, an ERK2 inhibitor probe (IC50 = 1.8 nM), may cause off-target toxicity and/or off-target activity at doses >10 μM. Synonyms: 1-[4-(Hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-[(1R)-1-phenylethyl]urea hydrochloride (1:1); Urea, N-[4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-N'-[(1R)-1-phenylethyl]-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C16H18ClN5O2. Mole weight: 347.80. | |
| ERK-IN-3 | ERK-IN-3 is a potent and orally active ERK inhibitor that can be used in cancer research caused by RAS mutations. It inhibits ERK1/2 with low single-digit nM IC50 values. Synonyms: N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide; ASN007 free base; NSC-828319; N-[(1S)-2-Amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(tetrahydro-2H-pyran-4-ylamino)-4-pyrimidinyl]-1H-imidazole-4-carboxamide. Grade: ≥99%. CAS No. 2055597-12-9. Molecular formula: C22H25ClFN7O2. Mole weight: 473.93. | |
| ERK-IN-3 benzenesulfonate | ERK-IN-3 benzenesulfonate is a potent and orally active ERK inhibitor that can be used in cancer research caused by RAS mutations. It inhibits ERK1/2 with low single-digit nM IC50 values. Synonyms: 1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-, compd. with benzenesulfonate (1:1). Grade: ≥98%. CAS No. 2055597-39-0. Molecular formula: C28H31ClFN7O5S. Mole weight: 632.11. | |
| ERK Inhibitor | ERK inhibitor, a reversible thiazolidinedione compound, is a cell-permeable inhibitor that binds ERK2 near its docking domain with a KD of 5 μM and prevents its interaction with protein substrates. Synonyms: Extracellular Regulated Kinase Inhibitor; 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride. Grade: ≥95%. CAS No. 1049738-54-6. Molecular formula: C14H16N2O3S·HCl. Mole weight: 328.8. | |
| Erlizumab | Erlizumab is a humanized monoclonal antibody that targets CD18. Erlizumab has been investigated as a therapy for hemorrhagic shock. Synonyms: rhuMAb. Grade: 95%. CAS No. 211323-03-4. | |
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