BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Glycyl-lactose | Glycyl-lactose is an indispensable biomedical compound, used for studying metabolic intricacies, particularly galactosemia. Synonyms: Glycyl-lactose (Lac-gly); Galβ1-4Glc-Gly-NH2. Grade: ≥95%. Molecular formula: C14H25NO12. Mole weight: 399.35. |  |
| Glycyl-Lewis A | Glycyl-Lewis A is an innovative compound, offering a potential strategy for the research of specific malignancies. As a synthetic mimic of the Lewis Y antigen and a remarkable carbohydrate configuration localized on malignant cells, the mechanism of action of Glycyl-Lewis A involves thwarting the detrimental interaction between cancerous cells and distinct protein counterparts. CAS No. 138430-53-2. Molecular formula: C22H39N3O15. Mole weight: 585.56. | |
| Glycyl-monosialyllacto-N-neohexose I | Glycyl-monosialyllacto-N-neohexose Ian extraordinary biomedical wonderemerges as a pivotal instrument, harnessing its immense prowess in studying afflictions of a specific nature. Its efficacy and uncanny ability to diligently pinpoint and strike down detrimental compounds, resulting in profound therapeutic advantages, truly awe-inspiring. Comprehensive insights and additional enlightenment can be explored within the confines of the provided web resources. Molecular formula: C53H89N5O39. Mole weight: 1420.28. | |
| Glycyl-monosialyl, monofucosyllacto-N-neohexose I | Glycyl-monosialyl, monofucosyllacto-N-neohexose I is a renowned compound used for studying a diverse array of diseases such as cancer, autoimmune disorders and neurodegeneration. Molecular formula: C59H99N5O43. Mole weight: 1566.43. | |
| Glycyl-Oligosaccharidesmannose 1 | Glycyl-Oligosaccharidesmannose 1 is an intriguing and cutting-edge biomedical resource, assuming an indispensable function by studying manifold maladies attributed to a scarcity of mannose. Molecular formula: C24H42N4O16. Mole weight: 642.61. | |
| Glycyl-Oligosaccharidesmannose 3(a) | Glycyl-Oligosaccharidesmannose 3(a) is a quintessential compound, unveiling its prowess in studying glycosylation disorders. Molecular formula: C36H62N4O26. Mole weight: 966.89. | |
| Glycyl-Oligosaccharidesmannose 5 | Glycyl-Oligosaccharidesmannose 5 is a crucial compound utilized in the biomedical industry to study beta-mannosidosis. This product aids in the breakdown of complex sugars, promoting enzyme activity and preventing the accumulation of harmful substances. It plays a vital role in studying symptoms associated with this rare genetic disorder. Molecular formula: C48H82N4O36. Mole weight: 1291.17. | |
| Glycyl-Oligosaccharidesmannose 6 | Glycyl-Oligosaccharidesmannose 6 is a biomedical compound serving for studying lysosomal storage disorders, most notably Mannosidosis. Functioning as a highly crucial substrate for the powerful enzyme β-mannosidase, it exerts a significant influence on the degradation process of surplus oligosaccharides. Molecular formula: C54H92N4O41. Mole weight: 1453.31. | |
| Glycyl-sialyllacto-N-tetraose a | Glycyl-sialyllacto-N-tetraose a is a remarkable biomedical compound, used for studying respiratory syncytial virus (RSV) and influenza virus infections. Molecular formula: C39H66N4O29. Mole weight: 1054.95. | |
| Glycyl-sialyllacto-N-tetraose b | Glycyl-sialyllacto-N-tetraose b, an extraordinary biomedical agent renowned for its profound applications in stduying bacterial infections and inflammation-related maladies. Molecular formula: C39H66N4O29. Mole weight: 1054.95. | |
| Glycyl-sialyllacto-N-tetraose c | Glycyl-sialyllacto-N-tetraose c is a gastroprotective bioactive derivative employed in biomedical applications to study diverse inflammatory ailments. Its innate anti-inflammatory characteristics enhance its applications in studying afflictions including rheumatoid arthritis and inflammatory bowel disease. Molecular formula: C39H66N4O29. Mole weight: 1054.95. | |
| Glycyrrhizinic acid, potassium salt | It can reduce ventricular arrhythmias caused by veratrol. Synonyms: Monopotassium glycyrrhizinate; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, potassiumsalt. CAS No. 68039-19-0. Molecular formula: C42H61KO16. Mole weight: 861.02. | |
| Gly double addition eptifibatide | An impurity of Eptifibatide. Eptifibatide is a glycoprotein IIb/IIIa inhibitor used primarily to prevent blood clots in patients with acute coronary syndromes (ACS) and during percutaneous coronary interventions (PCI). Synonyms: Mpr-Har-Gly-Gly-Asp-Trp-Pro-Cys-NH2(Mpr1&Cys8 bridge); Mpr-Har-GGDWPC-NH2(Mpr&Cys bridge); L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→7)-disulfide; deamino-Cys-hArg-Gly-Gly-Asp-Trp-Pro-Cys-NH2 (Disulfide bridge: Cys1-Cys8); Deamino-cysteinyl-L-homoarginyl-glycyl-glycyl-L-alpha-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide (1->8)-disulfide; Di-Gly3-Eptifibatide; (+Gly3)-Eptifibatide. Grade: ≥95%. CAS No. 868242-25-5. Molecular formula: C37H52N12O10S2. Mole weight: 889.02. | |
| Gly-Glu-Gly | Behold Gly-Glu-Gly, a tripeptide showing promising efficacy as a natural anti-inflammatory agent in biomedical contexts. Its potential is grounded in studies that have explored its aptitude for mitigating oxidative stress and inflammation in numerous diseases including rheumatoid arthritis, asthma, and cerebral ischemia/reperfusion injury. The full extent of its therapeutic potential, however, remains a topic of ongoing research and investigation. Synonyms: Gly-Glu-Gly; H-GLY-GLU-GLY-OH; glycylglutamylglycine. Grade: 98%. CAS No. 50997-16-5. Molecular formula: C9H15N3O6. Mole weight: 261.23. | |
| GlyH-101 | N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR. Synonyms: GlyH 101; GlyH101. Grade: >98%. CAS No. 328541-79-3. Molecular formula: C19H15Br2N3O3. Mole weight: 493.15. | |
| Gly-His-Lys | Gly-His-Lys is a tripeptide that can form a complex with copper ions. It is used for hair growth and skin care in cosmetics. It is a liver cell growth factor and stimulates hepatic erythropoietic factor production. It plays an important role in the care process of skin natural aging, such as cell proliferation, inflammation, angiogenesis, pigment formation and protein synthesis and regulation. Peptides are used in cosmetics to promote collagen production, anti-free radical oxidation, anti-inflammatory repair, anti-edema, whitening, breast enhancement and weight loss. It plays an important role in the care process of skin natural aging, such as cell proliferation, inflammation, angiogenesis, pigment formation and protein synthesis and regulation. Peptides are used in cosmetics to promote collagen production, anti-free radical oxidation, anti-inflammatory repair, anti-edema, whitening, breast enhancement and weight loss. Synonyms: L-Lysine, glycyl-L-histidyl-; L-Lysine, N2-(N-glycyl-L-histidyl)-; Glycyl-L-histidyl-L-lysine; GHK; GHK Tripeptide; Growth-modulating peptide; Growth-modulating peptide (human); Kollaren; Kollaren BG; Liver cell growth factor; Liver growth factor; NSC 379527; Prezatide; Tripeptide 1. Grade: ≥95%. CAS No. 49557-75-7. Molecular formula: C14H24N6O4. Mole weight: 340.38. | |
| Glymidine | Glycodiazine is a sulfapyrimidine derivative with antihyperglycemic activity used in biological activities to predict human intestinal absorption in drug discovery. Uses: Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. glycodiazine likely binds to atp-sensitive potassium channel receptors on the pancr. Synonyms: 2-Benzenesulfonamido-5-(2-methoxyethoxy)pyrimidine; Glidiazine; Glymidine; N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide. Grade: ≥98%. CAS No. 339-44-6. Molecular formula: C13H15N3O4S. Mole weight: 309.08. | |
| Glyoxalase I inhibitor | Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents. Synonyms: Glycine, L-γ-glutamyl-S-[[(4-bromophenyl)hydroxyamino]carbonyl]-L-cysteinyl-, diethyl ester, monohydrochloride (9CI). Grade: >98%. CAS No. 221174-33-0. Molecular formula: C21H30BrClN4O8S. Mole weight: 613.91. | |
| Glyparamide | Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity and rarely causes hepatic injury. Synonyms: Glyparamide; 5581-42-0; Glyparamide [USAN]; P-1306; 1-(4-chlorophenyl)sulfonyl-3-[4-(dimethylamino)phenyl]urea; 1-((p-chlorophenyl)sulfonyl)-3-(p-(dimethylamino)phenyl)urea; 4-Chloro-N-((4-(dimethylamino)phenyl)carbamoyl)benzenesulfonamide; Benzenesulfonamide, 4-chloro-N-(di-methylamino)phenyl)amino)carbonyl)-; 1-[([[(4-CHLOROPHENYL)SULFONYL]AMINO]CARBONYL)AMINO]-4-(DIMETHYLAMINO)BENZENE. Grade: >98%. CAS No. 5581-42-0. Molecular formula: C15H16ClN3O3S. Mole weight: 353.82. | |
| GlyRS-IN-1 | GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor. GlyRS-IN-1 can inhibit the growth of bacteria. Synonyms: 5'-O-(Glycylsulfamoyl)adenosine; Glycine sulfamoyl adenosine; 5'-[N-(2-Aminoacetyl)sulfamate]adenosine. Grade: 97%. CAS No. 112921-11-6. Molecular formula: C12H17N7O7S. Mole weight: 403.37. | |
| GlyT1 Inhibitor 1 | GlyT1 Inhibitor 1 is a potent and selective inhibitor of GlyT1 (IC50 = 38 nM for rGlyT1) with antipsychotic activity. Synonyms: Benzonitrile, 3-[[2,6-dihydro-2-(2-methyl-4-pyridinyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]carbonyl]-4-(1-methylethoxy)-; 4-Isopropoxy-3-(2-(2-methylpyridin-4-yl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)benzonitrile; 4-Isopropoxy-3-{[2-(2-methyl-4-pyridinyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]carbonyl}benzonitrile. Grade: ≥98%. CAS No. 1820934-93-7. Molecular formula: C22H21N5O2. Mole weight: 387.43. | |
| GM 1489 | GM 1489 is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. Synonyms: Hexanoic acid, 3-[[[(1S)-1-(1H-indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methyl-, (3R)-; (3R)-3-[[[(1S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]amino]carbonyl]-5-methylhexanoic acid; Hexanoic acid, 3-[[[1-(1H-indol-3-ylmethyl)-2-oxo-2-[(1-phenylethyl)amino]ethyl]amino]carbonyl]-5-methyl-, [3R-[3R*[S*(S*)]]]-; GM-1489; GM1489. Grade: ≥98%. CAS No. 171347-75-4. Molecular formula: C27H33N3O4. Mole weight: 463.57. | |
| GM1a Ganglioside oligosaccharide | GM1a Ganglioside oligosaccharide. Grade: 95%. CAS No. 67063-78-9. Molecular formula: C34H58N2O26. Mole weight: 910.8. | |
| GM1b Ganglioside oligosaccharide | GM1b-Oligosaccharide is an innovative and promising compound, showcasing its potential in studying complex neurodegenerative ailments including Parkinson's and Alzheimer's diseases. Derived from the GM1 ganglioside, this compound offers a remarkable neuroprotective effect by significantly augmenting neuronal survival and effectively thwarting cognitive decline. Molecular formula: C37H61N2O29Na. Mole weight: 1020.87. | |
| GM1-Lysoganglioside | GM1-Lysoganglioside, a highly esteemed biomedical agent, stands as a fostering solution amidst the intricate realm of neurodegenerative afflictions like Parkinson's disease and Alzheimer's disease. Synonyms: lyso-Monosialoganglioside GM1; Lyso-GM1; (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecenyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside; β-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-, [R-[R*,S*-(E)]]-. Grade: 95%. CAS No. 94458-59-0. Molecular formula: C55H97N3O30. Mole weight: 1280.36. | |
| GM1-Lysoganglioside potassium salt | GM1-Lysoganglioside potassium salt is a biomedicine utilized in the treatment of neurodegenerative disorders and nerve injuries. It acts as an essential neurotrophic factor in promoting nerve regeneration and maintaining neuronal survival. GM1-Lysoganglioside potassium salt has shown promising results in alleviating symptoms associated with diseases like Alzheimer's and Parkinson's, making it a potential therapeutic option for these conditions. Synonyms: lyso-Monosialoganglioside GM1 potassium salt; β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-, potassium salt (1:1); β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-, monopotassium salt; β-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-, monopotassium salt, [R-[R*,S*-(E)]]-. CAS No. 171483-40-2. Molecular formula: C55H96KN3O30. Mole weight: 1318. | |
| GM1-Pentasaccharide | GM1-Pentasaccharide, an auspicious compound in the field of biomedicine, holds substantial promise for the management of neurodegenerative ailments. Originating from the ganglioside GM1, this pentasaccharide exhibits remarkable prowess in augmenting neuronal rejuvenation and restoring impaired nerves. By virtue of its neuroprotective attributes, it manifests as an invaluable therapeutic asset for afflictions including Alzheimer's and Parkinson's disease. Synonyms: GM1-oligosaccharide; D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-[O-β-D-galactopyranosyl-(1→3)-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)]-O-β-D-galactopyranosyl-(1→4)-; O-β-D-Galactopyranosyl-(1→3)-O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)-O-[N-acetyl-α-neuraminosyl-(2→3)]-O-β-D-galactopyranosyl-(1→4)-D-glucose; Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc; GM1OS. CAS No. 52659-37-7. Molecular formula: C37H62N2O29. Mole weight: 998.88. | |
| GM1-Pentasaccharide, APD-HSA conjugate | GM1-Pentasaccharide, APD-HSA conjugate. | |
| GM2-Ganglioside | GM2-Ganglioside, a lipid molecule nestled in cellular membranes, has been linked to various pathologies of the central nervous system like Huntington's and Parkinson's disease. By delving into the underlying pathogenesis pathways, GM2-Ganglioside can serve as a potent therapeutic agent. As a clinical ingredient for vaccines against infectious diseases and a potential player in cancer therapy, this nano-molecule is showing promise as a versatile therapeutic option. Synonyms: Monosialoganglioside GM2; b-GalNAc-(1→4)-[a-Neu5Ac-(2→3)]-b-Gal(1→4)-b-Glc-(1→1)-Cer; Ganglioside GM2; Ganglioside A1; Ganglioside G5; Ganglioside GM2; Ganglioside GO; Ganglioside M2; GM2; Sialosylganglio-N-triaosylceramide; Tay-Sachs ganglioside. CAS No. 19600-01-2. | |
| GM2-Oligosaccharide | GM2-Oligosaccharide is a prominent constituent in the realm of biomedical applications, finding extensive utility in the investigation of lysosomal storage disorders. Acting as an invaluable compound in the scientific domain, this oligosaccharide facilitates the exploration of intricate processes underlying GM2 ganglioside metabolism. Synonyms: GM2 Ganglioside oligosaccharide. Molecular formula: C31H51N2O24Na. Mole weight: 858.73. | |
| GM2-Oligosaccharide-spacer-NH2 ammonium | GM2-Oligosaccharide-spacer-NH2 ammonium is a vital compound used in biomedicine. Its application lies in the treatment of GM2 gangliosidoses, a group of genetic disorders caused by the deficiency of vital enzymes. Synonyms: GalNAcb-4(NeuAca2-3)Galb-4Glcb-NAc-spacer-NH2. Molecular formula: C44H75N7O27.NH3. Mole weight: 1151.13. | |
| GM3-Ganglioside | GM3-Ganglioside, a renowned biomedical compound, is an exceptional therapeutic agent employed for managing debilitating neurodegenerative conditions, prominently encompassing Alzheimer's disease and Parkinson's disease. Its inherent proficiency in preserving neuronal coherence and functionality renders it indispensable in clinical practice. Synonyms: aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer; Ganglioside GM3; Ganglioside M3; Gangliosides, GM3; GLac1; GM3; Hematoside; Monosialodihexosylganglioside; Sialosyllactosylceramide. CAS No. 54827-14-4. | |
| GM3-Ganglioside labelled by NBD | GM3-Ganglioside labelled by NBD is a specialized GM3-Ganglioside molecule, known for its facile integration with NBD fluorescent probe. Its wide-ranging application encompasses unfathomable diseases, including cancer and neurodegenerative disorders. Synonyms: N-(Acetyl-a-D-neuraminic acid)-(2->3)-O-b-D-galactopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->1)-(2S,3R,4E)-2-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminooctanamido-4-octadecene-1,3-diol ammonium salt; aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer linked 7-nitrobenz-2-oxa-1,3-diazole. Molecular formula: C55H90N6O24 H3N. Mole weight: 1236.36. | |
| GM3-Ganglioside labelled by NBD ammonium | GM3-Ganglioside labelled by NBD ammonium is a vital tool in the biomedical industry used for researching and diagnosing various diseases. This product plays a crucial role in studying and understanding the targeting and metabolism of GM3-Ganglioside, a glycosphingolipid involved in neurological disorders and cancer progression. Its NBD ammonium label allows for fluorescence-based detection and visualization in biological systems, enabling accurate analysis and potential therapeutic advancements. Synonyms: (N-Acetyl-a-D-neuraminic acid)-(2->3)-O-b-D-galactopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->1)-(2S,3R,4E)-2-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminooctanamido-4-octadecene-1,3-diol ammonium salt; aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer linked 7-nitrobenz-2-oxa-1,3-diazole ammonium salt. Grade: 95%. Molecular formula: C55H90N6O24.NH3. Mole weight: 1236.36. | |
| GM3NeuGc-Ganglioside | GM3NeuGc-Ganglioside is an indispensable compound, catering to studying cancer. It operates as a remarkable ganglioside variant responsible for pivotal cellular communication and immune system activation. Synonyms: a-Neu5Gc-(2-3)-b-Gal-(1-4)-b-Glc-(1-1)-Cer. | |
| GM4-Ganglioside | GM4-Ganglioside is an essential glycosphingolipid exhibiting tremendous potential as a research for neurodegenerative ailments including Alzheimer's disease and Parkinson's disease. Through its remarkable neuroprotective properties, GM4-Ganglioside safeguard neurons from degeneration. CAS No. 66456-69-7. Molecular formula: C36H68N2O13. Mole weight: 736.9. | |
| GMC 1-116 | GMC 1-116 is a metabolite of clozapine with weak 5-HT2 affinity and high M1 affinity (IC50 = 27 nM). Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-8-ol; 8-Hydroxyclozapine; AC1L9SL1; 6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-3-ol. Grade: 99%. CAS No. 63687-94-5. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 1-165 | GMC 1-165 is an analogue of clozapine with 5-HT2A/2C and hM1 receptor affinities. Synonyms: 11-(4-Methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-2-ol; 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-ol. Grade: 99%. CAS No. 156632-07-4. Molecular formula: C18H20N4O. Mole weight: 308.38. | |
| GMC 1-169 | GMC 1-169 is an atypical antipsychotic devoid of muscarinic activity. Uses: Atypical antipsychotic. Synonyms: [6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grade: 99%. CAS No. 183140-97-8. Molecular formula: C19H19F3N4O3S. Mole weight: 440.44. | |
| GMC 15-27 | GMC 15-27 is a selective 5-HT1B/1D antagonist. Synonyms: 4'-(Aminoiminomethyl)-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-[1,1'-biphenyl]-4-carboxamide. Grade: 98%. CAS No. 256227-71-1. Molecular formula: C27H31N5O2. Mole weight: 457.57. | |
| GMC 2-113 | GMC 2-113 is a selective 5-HT1B antagonist. Synonyms: BDBM50084961; ZINC13805066; N-[4-hydroxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide. Grade: 98%. CAS No. 256227-77-7. Molecular formula: C28H29N5O3. Mole weight: 483.56. | |
| GMC 2-118 | GMC 2-118 is a potent and selective 5-HT1B antagonist. Synonyms: [4-[[4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoyl]amino]-2-(4-methylpiperazin-1-yl)phenyl] methanesulfonate. Grade: 98%. CAS No. 256227-78-8. Molecular formula: C29H31N5O5S. Mole weight: 561.65. | |
| GMC 2-29 | GMC 2-29 is a potent and selective 5-HT1B/1D antagonist. Synonyms: N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide. Grade: 99%. CAS No. 148672-15-5. Molecular formula: C29H31N5O3. Mole weight: 497.59. | |
| GMC 2-83 | GMC 2-83 is an atypical antipsychotic without muscarinic activity. Uses: Atypical antipsychotic. Synonyms: [6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-8-yl] trifluoromethanesulfonate. Grade: 99%. CAS No. 183140-98-9. Molecular formula: C19H18F3N3O4S. Mole weight: 441.42. | |
| GMC 3-15 | GMC 3-15 is a potent and selective 5-HT1B/1D antagonist. Synonyms: 4-[4-[[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]carbamoyl]phenyl]-3-methylbenzamide. Grade: 99%. CAS No. 691846-63-6. Molecular formula: C27H30N4O3. Mole weight: 458.55. | |
| GMC 61-39 | GMC 61-39 is a clozapine-like atypical antipsychotic. Uses: Atypical antipsychotic. Synonyms: [3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grade: 98%. CAS No. 234113-94-1. Molecular formula: C19H18ClF3N4O3S. Mole weight: 474.88. | |
| GMP | Guanosine 5'-monophosphate has been found to be useful in studies of modulation of glutamatergic neurotransmission. Synonyms: Guanosine-5'-monophosphate; 5'-Guanylic Acid. Grade: ≥ 95 % by HPLC. Molecular formula: C10H14N5O8P. Mole weight: 363.22. | |
| GMPαS | GMPαS, a synthesized protein of biotechnological application, is utilized in the biomedical sector for the purpose of investigation into the sprawling domain of inflammatory bowel disease (IBD). This recombinant compound fosters an effective anti-inflammatory response via the suppression of cytokine production associated with the onset of IBD. Additionally, GMPαS's therapeutic possibilities are gaining increasing scientific traction as a potential target for treating a gamut of autoimmune and underlying inflammatory maladies. Synonyms: Guanosine-5'-(α-thio)-monophosphate, Sodium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C10H14N5O7PS (free acid). Mole weight: 379.28 (free acid). | |
| GMQ hydrochloride | GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. It alters the pH dependence of ASIC1a and ASIC1b with no effect on the activation curve of ASIC2a. Synonyms: GMQ monohydrochloride; GMQ HCl; NSC-403387 hydrochloride; NSC 403387 hydrochloride; NSC403387 hydrochloride; NSC-403387 HCl; NSC 403387 HCl; NSC403387 HCl; N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride; 1-(4-Methylquinazolin-2-yl)guanidine hydrochloride. Grade: ≥98% by HPLC. CAS No. 5361-15-9. Molecular formula: C10H11N5.HCl. Mole weight: 237.69. | |
| GN 44028 | GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). It suppresses hypoxia-induced HIF-1α transcriptional activity with no effect on HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Synonyms: GN44028; GN 44028; GN-44028; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine. Grade: ≥98% by HPLC. CAS No. 1421448-26-1. Molecular formula: C18N15N3O2. Mole weight: 305.33. | |
| GNA002 | GNA002 is a specific, highly potent and covalent EZH2 (enhancer of zeste homolog 2) inhibitor (IC50 = 1.1 μM) that can specifically and covalently bind to Cys668 in the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. It efficiently reduces EZH2-mediated H3K27 trimethylation and reactivates the tumor suppressor genes silenced by polycomb repressor complex 2 (PRC2). Synonyms: (2Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methyl-2-buten-1-yl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-N-(2-ethoxyethyl)-2-methyl-2-butenamide; 2-Butenamide, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-N-(2-ethoxyethyl)-2-methyl-, (2Z)-. Grade: ≥98%. CAS No. 1385035-79-9. Molecular formula: C42H55NO8. Mole weight: 701.89. | |
| GNA2 N-Glycan | GNA2 N-Glycan is a resplendent biomedicine used for stduying cancer, inflammatory disorders, and neurodegenerative conditions. Synonyms: Monogalacto, fucosylated, biantennary N-linked glycan. | |
| Gnaphaline | A derivative of Flavoxate. Flavoxate is an anticholinergic with antimuscarinic effects. Synonyms: 4H-1-Benzopyran-4-one,5,7-dihydroxy-3,8-dimethoxy-2-phenyl-; 5,7-Dihydroxy-3,8-Dimethoxyflavon. Grade: > 95%. CAS No. 33803-42-8. Molecular formula: C17H14O6. Mole weight: 314.30. | |
| GNE-0439 | GNE-0439 is an ion channel selective blocker with effect of relieving pain. Synonyms: (4-(4-Propylcyclohexyl)benzoyl)-L-valine; GNE 0439. CAS No. 1241902-40-8. Molecular formula: C21H31NO3. Mole weight: 345.48. | |
| GNE-049 | GNE-049 is a selective and highly potent inhibitor of CBP with an IC50 of 1.1 nM in TR-FRET assay. It also inhibits BRET and BRD4 with IC50s of 12 and 4200 nM, respectively. Synonyms: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one; 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-(oxan-4-yl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one; Ethanone, 1-[3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-1-(tetrahydro-2H-pyran-4-yl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-. Grade: ≥98%. CAS No. 1936421-41-8. Molecular formula: C27H32F2N6O2. Mole weight: 510.58. | |
| GNE-0877 | GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. Synonyms: GNE0877; GNE 0877; GNE-0877. CAS No. 1374828-69-9. Molecular formula: C14H16F3N7. Mole weight: 339.326. | |
| GNE-131 | GNE-131 is a potent and selective hNaV1.7 inhibitor with IC50 of 3 nM. Synonyms: GNE 131; GNE131. Grade: 98% by HPLC. CAS No. 1629063-81-5. Molecular formula: C23H30N4O3S. Mole weight: 442.6. | |
| GNE-140 racemate | GNE-140 racemate is the racemate of GNE-140, a potent lactate dehydrogenase A (LDHA) inhibitor. Synonyms: GNE-140 (racemate). Grade: 98% by HPLC. CAS No. 1802977-61-2. Molecular formula: C25H23ClN2O3S2. Mole weight: 499.0. | |
| GNE-1858 | GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor. Grade: 99%. CAS No. 2680616-96-8. Molecular formula: C21H26F2N8. Mole weight: 428.48. | |
| GNE 220 | GNE 220 is a potent and selective MAP4K4 inhibitor with an IC50 of 7 nM. Synonyms: GNE-220; GNE220. CAS No. 1199590-75-4. Molecular formula: C25H26N8. Mole weight: 438.54. | |
| GNE 220 hydrochloride | GNE 220 is a potent and selective MAP4K4 inhibitor with an IC50 of 7 nM. Grade: 98%. CAS No. 2448286-21-1. Molecular formula: C25H27ClN8. Mole weight: 474.99. | |
| GNE-272 | GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50s of 0.02, 0.03, 0.41 and 13 μM for CBP, EP300, BRET and BRD4, respectively. It shows significant antiproliferative effects in hematologic cancer cell lines and modulates MYC expression in vivo, corresponding to antitumor activity in AML tumor models. It is also a selective in vivo probe for the Bromodomains of CBP/EP300. Synonyms: (S)-1-(3-((2-fluoro-4-(1-methyl-1h-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one; N-[2-Fluoro-4-(1-methyl-1H-pyrazole-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3beta-yl]-5-acetyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-amine; 1-(3-{[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-1-[(3S)-oxolan-3-yl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one. Grade: ≥95%. CAS No. 1936428-93-1. Molecular formula: C22H25FN6O2. Mole weight: 424.47. | |
| GNE-274 | GNE-274, a non-degrader structurally related to GDC-0927 (ER degrader), does not induce ER turnover and acts as a partial ER agonist in breast cancer cell lines. It increases chromatin accessibility of ER-DNA binding sites, while GDAC-0927 does not. It is a potent ER ligand-binding domain (LBD) inhibitor and can be used for the study of cancer. Synonyms: 2H-1-Benzopyran-6-ol, 3-(3-hydroxyphenyl)-4-methyl-2-[4-[(1-propyl-3-azetidinyl)methoxy]phenyl]-, (2S)-. CAS No. 2369048-69-9. Molecular formula: C29H31NO4. Mole weight: 457.56. | |
| GNE 2861 | GNE-2861 is a potent and selective inhibitor of the group 2 p21-activated kinases (PAKs; IC50s = 7.5, 126, and 36 nM for PAK4, -5, and -6, respectively). Synonyms: 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol; 1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol. Grade: ≥98% by HPLC. CAS No. 1394121-05-1. Molecular formula: C22H26N6O2. Mole weight: 406.48. | |
| GNE-317 | GNE-317 is a potent and selective PI3K inhibitor with potential anticncer activity. GNE-317 targets the PI3K pathway and can cross the Blood-Brain Barrier. GNE-317 was identified as having physicochemical properties predictive of low efflux by P-gp and BCRP. Studies in transfected MDCK cells showed that GNE-317 was not a substrate of either transporter. GNE-317 markedly inhibited the PI3K pathway in mouse brain, causing 40% to 90% suppression of the pAkt and pS6 signals up to 6-hour postdose. GNE-317 was efficacious in the U87, GS2, and GBM10 orthotopic models, achieving tumor growth inhibition of 90% and 50%, and survival benefit, respectively. GNE-317 could be effective in the treatment of GBM. Synonyms: GNE-317; GNE 317; GNE317. Grade: >98%. CAS No. 1394076-92-6. Molecular formula: C19H22N6O3S. Mole weight: 414.48. | |
| GNE-3500 | GNE-3500 has been found to be a Retinoic acid receptor-related Orphan receptor C agonist that could be probably significant in studies of some inflammatory diseases. Synonyms: GNE-3500; GNE 3500; GNE3500; 1-(4-(3-fluoro-4-(((3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl)methyl)phenyl)piperazin-1-yl)ethan-1-one. Grade: 98%. CAS No. 1537859-24-7. Molecular formula: C24H30FN3O3S. Mole weight: 459.58. | |
| GNE-3511 | GNE-3511 has been found to be a DLK, MAP3K12 kinase inhibitor that could probably exhibit protection action of primary neurons. IC50: 0.107 uM (DLK). Synonyms: GNE-3511; GNE 3511; GNE3511. CHEMBL3393333; SCHEMBL15602439; BDBM50059190; 2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile. Grade: 98%. CAS No. 1496581-76-0. Molecular formula: C23H26F2N6O. Mole weight: 440.50. | |
| GNE-477 | GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR. Synonyms: GNE-477, GNE477, GNE 477. Grade: >98%. CAS No. 1032754-81-6. Molecular formula: C21H28N8O3S2. Mole weight: 504.63. | |
| GNE-493 | GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. Synonyms: GNE493; GNE-493; GNE 493. Grade: >98%. CAS No. 1033735-94-2. Molecular formula: C17H20N6O2S. Mole weight: 372.44. | |
| GNE-495 | GNE-495 is a Selective MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) Inhibitor. IC50 value is 3.7 nM. GNE-495 shows excellent potency and good PK In vivo. GNE-495 was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that are observed in the inducible Map4k4 knockout mice. Synonyms: GNE-495; GNE 495; GNE495. 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide. Grade: 98%. CAS No. 1449277-10-4. Molecular formula: C22H20FN5O2. Mole weight: 405.43. | |
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