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[Des-Arg9]-Bradykinin acetate
[Des-Arg9]-Bradykinin acetate is a selective Bradykinin(B1) receptor agonist and increases intracellular Ca2+ in bronchoalveolar eosinophils from ovalbumin-sensitized and -challenged mice. Alternative Names: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH.CH3CO2H; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine acetic acid; 9-De-arg-bradykinin acetate; 9-Des-arg-BK acetate; Des-arg(9)-bradykinin acetate; 9-de-L-Argininebradykinin acetate; 1-8-Bradykinin acetate. Grades: ≥95%. CAS No. 23827-91-0. Molecular formula: C46H65N11O12. Mole weight: 964.07.
[Des-Arg9]-Bradykinin TFA
[Des-Arg9]-Bradykinin TFA is a selective Bradykinin(B1) receptor agonist and increases intracellular Ca2+ in bronchoalveolar eosinophils from ovalbumin-sensitized and -challenged mice. Alternative Names: 1-8-Bradykinin, mono(trifluoroacetate) (salt); H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH.TFA; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine trifluoroacetic acid. Grades: ≥95%. CAS No. 199433-70-0. Molecular formula: C44H61N11O10.C2HF3O2. Mole weight: 1018.05.
(Des-Asp1)-Angiotensin I
(Des-Asp1)-Angiotensin I. Alternative Names: Angiotensin I [Des-Asp1-](human); H-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH. CAS No. 56317-01-2. Molecular formula: C58H84N16O11. Mole weight: 1181.39.
(Des-Bromo)-Neuropeptide B (1-23) (human)
(Des-Bromo)-Neuropeptide B (1-23) (human), a neuropeptide B derivative, inhibits forskolin-induced cAMP production to a similar degree as neuropeptide B (human) in CHO-cells expressing bovine or human G-protein-coupled receptor GPR7, with IC50s of 3.5 and 0.58 nM for bovine and human GPR7, respectively. Alternative Names: DesBr-NPB-23 (human); H-Trp-Tyr-Lys-Pro-Ala-Ala-Gly-His-Ser-Ser-Tyr-Ser-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Ser-Gly-Leu-OH; L-tryptophyl-L-tyrosyl-L-lysyl-L-prolyl-L-alanyl-L-alanyl-glycyl-L-histidyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-valyl-glycyl-L-arginyl-L-alanyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-glycyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 434897-64-0. Molecular formula: C107H162N30O30. Mole weight: 2348.61.
(Des-Glu22)-Amyloid β-Protein (1-40)
Osaka mutation is the first deletion type mutation found in APP and Aβ. Aβ E22delta mutant is more resistant to degradation of two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. The synthetic mutant Aβ has unusual aggregation properties, with enhanced oligomerization but no fibrillization. It inhibits long-term hippocampal enhancement more effectively than wild-type Aβ. Alternative Names: Amyloid β-Protein (1-40) Osaka or Japanese Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 1678416-36-8. Molecular formula: C189H288N52O55S. Mole weight: 4200.75.
(Des-Glu22)-Amyloid β-Protein (1-42)
(Des-Glu22)-Amyloid β-Protein (1-42), the Osaka (E22delta) mutation of Amyloid β, promotes β-sheet transformation, free radical production, and synaptic toxicity, but is not neurotoxic. Alternative Names: Amyloid β-Protein (1-42) Japanese Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. CAS No. 1239313-74-6. Molecular formula: C198H304N54O57S. Mole weight: 4384.99.
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon). Alternative Names: PYR-HIS-TRP-SER-TYR-D-ALA-TRP-LEU-PRO-NHET; L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-alanyl-L-tryptophyl-L-leucyl-N-ethyl-. CAS No. 88848-87-7. Molecular formula: C61H76N14O12. Mole weight: 1197.34.
(Des-Gly10,D-Ser(tBu)6,Pro-NHNH29)-LHRH
(Des-Gly10,D-Ser(tBu)6,Pro-NHNH29)-LHRH is the impurity E of the Goserelin. Alternative Names: Decarbamoylgoserelin; H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNH2; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-prolinehydrazide; 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), hydrazide. Grades: 95%. CAS No. 147688-42-4. Molecular formula: C58H83N17O13. Mole weight: 1226.39.
(Des-Gly29)-Liraglutide trifluoroacetate salt
(Des-Gly29)-Liraglutide trifluoroacetate salt is an impurity of Liraglutide. Alternative Names: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γ-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Arg-Gly-OH trifluoroacetate salt. Molecular formula: C170H262N42O50.C2HF3O2. Mole weight: 3808.16.
(Des-Gly2)-Exenatide
(Des-Gly2)-Exenatide is a potential impurity of exenatide. Alternative Names: (Des-Gly2)-Exendin-4; H-His-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678416-78-8. Molecular formula: C182H279N49O59S. Mole weight: 4129.58.
(Des-Gly31)-Liraglutide trifluoroacetate salt
(Des-Gly31)-Liraglutide trifluoroacetate salt is an impurity of Liraglutide. Alternative Names: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γ-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-OH trifluoroacetate salt. Molecular formula: C170H262N42O50.C2HF3O2. Mole weight: 3808.16.
(Des-His1)-Glucagon trifluoroacetate salt is an impurity of glucagon. Alternative Names: Glucagon (2-29) TFA; H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH TFA; L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threonine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C147H218N40O48S.C2HF3O2. Mole weight: 3459.62.
(Des-L-threoninol8)-Octreotide amide
(Des-L-threoninol8)-Octreotide amide is a potential impurity of octreotide. Octreotide is a synthetic somatostatin analog used to treat conditions involving excessive hormone production. It is administered via subcutaneous or intravenous injection and is effective in managing acromegaly, carcinoid syndrome, and Zollinger-Ellison syndrome. Alternative Names: DPhe-Cys-Phe-DTrp-Lys-Thr-Cys-NH2(Cys2&Cys7 bridge); H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH2 (Disulfide bridge: Cys2-Cys7); D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinamide cyclic (2-7)-disulfide; DPhe-CF-DTrp-KTC-NH2(Cys2&Cys7 bridge); (Des-Thr-ol8)-Octreotide amide; [Des-Thr-ol8]-Cys7-amide-Octreotide; L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-, cyclic (2→7)-disulfide. Grades: ≥95%. CAS No. 79486-60-5. Molecular formula: C45H58N10O8S2. Mole weight: 931.13.
[Des-octanoyl]-Ghrelin (human) is a major circulating form of ghrelin. It inhibits cell proliferation in breast and prostate cancer cell lines. Alternative Names: Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg. CAS No. 313951-59-6. Molecular formula: C141H235N47O41. Mole weight: 3244.70.
(Des-Pro3, Hyp4) Icatibant impurity
(Des-Pro3, Hyp4) Icatibant impurity is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Alternative Names: Des[Pro(3)-Hyp(4)]-Icatibant; (D-Arg)-Arg-Gly-Thi-Ser-(D-Tic)-Oic-Arg; D-Arg-Arg-Gly-Thi-Ser-D-Tic-Oic-Arg. Molecular formula: C49H75N17O10S. Mole weight: 1094.2.
(Des-Pro9), (D-Ala)10, Degarelix
(Des-Pro9), (D-Ala)10, Degarelix. Alternative Names: Ac-(D-2-Nal)-(D-4-Cpa)-(D-3-Pal)-Ser-[4-Aph(Hor)]-[D-4-Aph(carbamoyl)]-Leu-Lys(Ipr)-NH2. Mole weight: 1463.5.
(DES-PYR1)-LHRH
(DES-PYR1)-LHRH. Alternative Names: LHRH (2-10); H-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. CAS No. 38280-53-4. Molecular formula: C50H70N16O11. Mole weight: 1071.19.
(Des-Thr5)-Glucagon
(Des-Thr5)-Glucagon. Alternative Names: H-His-Ser-Gln-Gly-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH; L-Histidyl-L-seryl-L-glutaminylglycyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine. Grades: ≥95%. CAS No. 1802078-27-8. Molecular formula: C149H218N42O47S. Mole weight: 3381.64.
(Des-Thr7)-Glucagon
(Des-Thr7)-Glucagon. Alternative Names: H-His-Ser-Gln-Gly-Thr-Phe-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH; L-Histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine. Grades: ≥95%. CAS No. 1802078-28-9. Molecular formula: C149H218N42O47S. Mole weight: 3381.64.
(D-His1)-Exenatide
(D-His1)-Exenatide is an impurity of exenatide. Alternative Names: (D-His1)-Exendin-4; H-D-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: ≥95%. CAS No. 1678417-09-8. Molecular formula: C184H282N50O60S. Mole weight: 4186.63.
(D-His2,D-Trp6)-LHRH
(D-His2,D-Trp6)-LHRH. Alternative Names: H-Pyr-D-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. CAS No. 321709-34-6. Molecular formula: C64H82N18O13. Mole weight: 1311.45.
(D-Homo-Arg)2 Eptifibatide impurity
(D-Homo-Arg)2 Eptifibatide impurity. Alternative Names: Mpr-(D-Homo-Arg)-Gly-Asp-Trp-Pro-Cys-NH2 (Disulfide bond Mpr1/Cys7). Molecular formula: C28H33O7S2N7. Mole weight: 643.70.
(D-Hyp)4, Icatibant impurity
(D-Hyp)4, Icatibant impurity is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Alternative Names: (D-Arg)-Arg-Pro-(D-Hyp)-Gly-Thi-Ser-(D-Tic)-Oic-Arg; D-Arg-Arg-Pro-D-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg. Molecular formula: C59H89N19O13S. Mole weight: 1304.50.
(Diacetyl)-α-MSH
(Diacetyl)-α-MSH, a synthetic peptide, has been investigated extensively for its prospective applications in the management of autoimmune and inflammatory ailments, like rheumatoid arthritis and multiple sclerosis. Its anti-inflammatory properties and the ability to modulate the immune system by regulating cytokine production have been well documented. Furthermore, its efficacy as a treatment option for melanoma and obesity has been studied due to its influence on melanocortin receptors. The compound offers remarkable potential as an agent for mitigating various diseases. Alternative Names: a-Melanotropin (swine), 1-(N,O-diacetyl-L-serine)-; Ac-Ser(Ac)-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. Grades: 98%. CAS No. 71952-90-4. Molecular formula: C79H111N21O20S. Mole weight: 1706.92.
(DL-Isoser1)-TRAP-6
(DL-Isoser1)-TRAP-6. Alternative Names: H-DL-Isoser-Phe-Leu-Leu-Arg-Asn-OH; (DL-Isoser1)-TRAP-6. CAS No. 150242-29-8. Molecular formula: C34H56N10O9. Mole weight: 748.87.
(D-Met)14, Exendin-4
Exendin-4 (Exenatide), an agonist of glucagon-like peptide 1 (GLP-1) receptor, induces release of insulin after food intake. Alternative Names: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-(D-Met)-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Molecular formula: C184H282N50O60S. Mole weight: 4186.56.
(D)-N-CBZ-Pipecolic acid
(D)-N-CBZ-Pipecolic acid. Alternative Names: (R)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid. CAS No. 28697-09-8. Molecular formula: C14H17NO4. Mole weight: 263.3.
[DOTA-(Bn-pSCN)], pHLIP var3 (D)
[DOTA-(Bn-pSCN)], pHLIP var3 (D) is a derivative of pHLIP var3, a pH low insertion peptide used as a marker of low pH in tumor allografts and of malignant lesions. Alternative Names: DOTA-(Bn-pSCN)-D-Ala-D-Cys-D-Asp-D-Asp-D-Gln-D-Asn-D-Pro-D-Trp-D-Arg-D-Ala-D-Tyr-D-Leu-D-Asp-D-Leu-D-Leu-D-Phe-D-Pro-D-Thr-D-Asp-D-Thr-D-Leu-D-Leu-D-Leu-D-Asp-D-Leu-D-Leu-D-Trp; DOTA-(Bn-pSCN)-Ala-Cys-Asp-Asp-Gln-Asn-Pro-Trp-Arg-Ala-Tyr-Leu-Asp-Leu-Leu-Phe-Pro-Thr-Asp-Thr-Leu-Leu-Leu-Asp-Leu-Leu-Trp (All D AA). Mole weight: 3773.43.
[DOTA-(Bn-pSCN)], pHLIP var7 (D)
[DOTA-(Bn-pSCN)], pHLIP var7 (D) is a derivative of pHLIP var7, which is the shortest and most polar peptide sequence in the pHLIP family targeting the tumor. Alternative Names: DOTA-(Bn-pSCN)-D-Ala-D-Cys-D-Glu-D-Glu-D-Gln-D-Asn-D-Pro-D-Trp-D-Ala-D-Arg-D-Tyr-D-Leu-D-Glu-D-Trp-D-Leu-D-Phe-D-Pro-D-Thr-D-Glu-D-Thr-D-Leu-D-Leu-D-Leu-D-Glu-D-Leu; DOTA-(Bn-pSCN)-Ala-Cys-Glu-Glu-Gln-Asn-Pro-Trp-Ala-Arg-Tyr-Leu-Glu-Trp-Leu-Phe-Pro-Thr-Glu-Thr-Leu-Leu-Leu-Glu-Leu (All D AA). Mole weight: 3617.2.
[DOTA-(Bn-pSCN)], pHLIP WT (D)
[DOTA-(Bn-pSCN)], pHLIP WT (D) is a derivative of pHLIP-WT, a pH low insertion peptide used as a marker of low pH in tumor allografts and of malignant lesions. Alternative Names: DOTA-(Bn-pSCN)-D-Ala-D-Cys-D-Glu-D-Gln-D-Asn-D-Pro-D-Ile-D-Tyr-D-Trp-D-Ala-D-Arg-D-Tyr-D-Ala-D-Asp-D-Trp-D-Leu-D-Phe-D-Thr-D-Thr-D-Pro-D-Leu-D-Leu-D-Leu-D-Leu-D-Asp-D-Leu-D-Ala-D-Leu-D-Leu-D-Val-D-Asp-D-Ala-D-Asp-D-Glu-D-Gly-D-Thr; DOTA-(Bn-pSCN)-Ala-Cys-Glu-Gln-Asn-Pro-Ile-Tyr-Trp-Ala-Arg-Tyr-Ala-Asp-Trp-Leu-Phe-Thr-Thr-Pro-Leu-Leu-Leu-Leu-Asp-Leu-Ala-Leu-Leu-Val-Asp-Ala-Asp-Glu-Gly-Thr (All D AA). Mole weight: 4663.4.
[D-p-Cl-Phe6,Leu17]-VIP
[D-p-Cl-Phe6,Leu17]-VIP is a selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM) with no activity at glucagon, secretin or GRF receptors. Alternative Names: [D-p-Cl-Phe6, Leu17]-Vasoactive Intestinal Peptide human, porcine, rat. CAS No. 102805-45-8. Molecular formula: C148H239ClN44O42. Mole weight: 3342.24.
(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide, a synthetic somatostatin analogue, is selective for human somatostatin receptor subtype 5 (hsst5) and has similar binding affinity to somatostatin-28, with Kd±SEM values of 1200, 23.5±3.92, 11.05±1.03, >1000 and 0.61±0.36 nM for hsst1, hsst2, hsst3, hsst4 and hsst5, respectively. Alternative Names: (N-Me-D-Trp4,Thr8)-Octreotide amide; H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7); D-phenylalanyl-L-cysteinyl-L-phenylalanyl-N-methyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninamide (2->7)-disulfide. Grades: ≥95% by HPLC. CAS No. 340821-13-8. Molecular formula: C50H67N11O10S2. Mole weight: 1046.26.
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14)
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) is an antagonist of bombesin receptor with IC50 values for cellular secretion and growth approaching the picomolar region. Alternative Names: D-Phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-N-ethyl-L-leucinamide; H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt; L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-N-ethyl-; DPDMB. Grades: 95%. CAS No. 124199-90-2. Molecular formula: C49H69N13O9. Mole weight: 984.15.
(D-Phe7)-Somatostatin-14
(D-Phe7)-Somatostatin-14. Alternative Names: H-Ala-Gly-Cys-Lys-Asn-Phe-D-Phe-Trp-Lys-Thr-Phe-Thr-Ser-D-Cys-OH. CAS No. 64813-74-7. Molecular formula: C76H104N18O19S2. Mole weight: 1637.88.
D-(+)-Phenyllactic acid
D-(+)-Phenyllactic acid, an antibacterial agent excreted by Geotrichum candidum, inhibits a range of gram-positive bacteria in humans and foodstuffs as well as gram-negative bacteria found in humans. Alternative Names: D-3-Phenyllactic acid; D-(+)-3-Phenyllactic Acid; (+)-2-Hydroxy-3-phenylpropanoic Acid; (+)-2-Hydroxy-3-phenylpropionic Acid; (+)-β-Phenyllactic Acid; (2R)-2-Hydroxy-3-phenylpropionic Acid; (2R)-3-Phenyl-2-hydroxypropanoic Acid; (R)-2-Hydroxy-3-phenylpropionic Acid; (R)-3-Phenyl-2-hydroxypropanoic Acid; (R)-3-Phenyl-2-hydroxypropionic Acid; (R)-3-Phenyllactic Acid; (R)-Phenyllactic Acid; (R)-α-Hydroxy-3-phenylpropionic Acid; (R)-β-Phenyllactic Acid; D-2-Hydroxy-3-phenylpropionic Acid; D-β-Phenyllactic Acid; β-Phenyl-D-lactic Acid. Grades: ≥95%. CAS No. 7326-19-4. Molecular formula: C9H10O3. Mole weight: 166.17.
(D-Pro)3, Icatibant impurity
(D-Pro)3, Icatibant impurity is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Alternative Names: (D-Arg)-Arg-(D-Pro)-Hyp-Gly-Thi-Ser-(D-Tic)-Oic-Arg; D-Arg-Arg-D-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg. Molecular formula: C59H89N19O13S. Mole weight: 1304.50.
(D-Pro7)-Angiotensin I/II (1-7)
(D-Pro7)-Angiotensin I/II (1-7) is a selective antagonist of angiotensin (1-7). Alternative Names: DPro7-angiontensin-(1-7); H-Asp-Arg-Val-Tyr-Ile-His-D-Pro-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-proline; L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-proline. Grades: ≥95%. CAS No. 586962-44-9. Molecular formula: C41H62N12O11. Mole weight: 899.02.
(D-Ser)7, Icatibant impurity
(D-Ser)7, Icatibant impurity is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Alternative Names: (D-Arg)-Arg-Pro-Hyp-Gly-Thi-(D-Ser)-(D-Tic)-Oic-Arg; D-Arg-Arg-Pro-Hyp-Gly-Thi-D-Ser-D-Tic-Oic-Arg. Molecular formula: C59H89N19O13S. Mole weight: 1304.50.
(D-Thi)6, Icatibant impurity
(D-Thi)6, Icatibant impurity is an impurity of Icatibant, which is a selective and specific antagonist of bradykinin B2 receptor. Alternative Names: (D-Arg)-Arg-Pro-Hyp-Gly-(D-Thi)-Ser-(D-Tic)-Oic-Arg; D-Arg-Arg-Pro-Hyp-Gly-D-Thi-Ser-D-Tic-Oic-Arg. Molecular formula: C59H89N19O13S. Mole weight: 1304.50.
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine). Alternative Names: H-PHE-MET-HIS-ASN-LEU-D-TRP-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-TYR-NH2. CAS No. 118102-98-0. Molecular formula: C165H251N49O40S2. Mole weight: 3625.18.
(D-Trp6,D-Leu7)-LHRH
(D-Trp6,D-Leu7)-LHRH. Alternative Names: H-Pyr-His-Trp-Ser-Tyr-D-Trp-D-Leu-Arg-Pro-Gly-NH2. CAS No. 321709-37-9. Molecular formula: C64H82N18O13. Mole weight: 1311.45.
(D-Trp6)-LHRH (1-6) amide
(D-Trp6)-LHRH (1-6) amide. Alternative Names: pGlu-HWSY-DTrp-NH2; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophanamide; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophanamide. Grades: ≥95%. CAS No. 1217367-73-1. Molecular formula: C45H49N11O9. Mole weight: 887.95.
(D-Trp6)-LHRH (2-10)
(D-Trp6)-LHRH (2-10). Alternative Names: (Des-Pyr1,D-Trp6)-LHRH; H-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2; L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide; 6-Tryptophan-LHRH (2-10); 6-Trp-LHRH (2-10); Swine 1-de(5-oxo-L-proline)-6-D-tryptophanluteinizing hormone-releasing factor. Grades: ≥95% by HPLC. CAS No. 108787-46-8. Molecular formula: C59H77N17O11. Mole weight: 1200.35.
(D-Trp6)-LHRH-Leu-Arg-Pro-Gly amide
(D-Trp6)-LHRH-Leu-Arg-Pro-Gly amide. Alternative Names: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide; Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycyl-L-leucyl-L-arginyl-L-prolyl-; H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide. Grades: ≥95%. CAS No. 1926163-16-7. Molecular formula: C83H115N25O17. Mole weight: 1734.98.
[D-Trp7,9,10]-Substance P acetate
[D-Trp7,9,10]-Substance P acetate is an analogue of substance P. Substance P inhibits ion conductance through nicotinic acetylcholine receptors. Molecular formula: C81H109N21O15S. Mole weight: 1648.93.
[D-Trp8]-γ-MSH
[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50= 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). It displays antiinflammatory efficacy in mice bearing a non-functional MC1R (recessive yellow e/e mouse) and these effects are abrogated in the presence of the HO-1 inhibitor ZnPPIX. Alternative Names: L-tyrosyl-L-valyl-L-methionyl-glycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-alpha-aspartyl-L-arginyl-L-phenylalanyl-glycine. CAS No. 321351-81-9. Molecular formula: C74H99N21O16S. Mole weight: 1570.79.
[D-Trp8]-γ-MSH acetate
[D-Trp8]-γ-MSH acetate is a selective melanocortin 3 (MC3) receptor agonist (IC50 = 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors, respectively). It displays antiinflammatory efficacy in mice bearing a non-functional MC1R (recessive yellow e/e mouse) and these effects are abrogated in the presence of the HO-1 inhibitor ZnPPIX. Alternative Names: CTX-1100 acetate; L-Tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalanylglycine acetate; H-Tyr-Val-Met-Gly-His-Phe-Arg-D-Trp-Asp-Arg-Phe-Gly-OH.CH3CO2H. Grades: ≥95%. Molecular formula: C76H103N21O18S. Mole weight: 1630.82.
[D-Trp8]-γ-MSH TFA
[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). It displays anti-inflammatory efficacy. Alternative Names: CTX-1100 trifluoroacetate; L-Tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalanylglycine trifluoroacetate; H-Tyr-Val-Met-Gly-His-Phe-Arg-D-Trp-Asp-Arg-Phe-Gly-OH.TFA. Grades: ≥95%. Molecular formula: C76H100F3N21O18S. Mole weight: 1684.79.
(D-Trp8)-Somatostatin-14
(D-Trp8)-Somatostatin-14, a somatostatin analogue, is 6-8 times more potent than somatostatin in inhibiting growth hormone, glucagon and insulin release. It may be better resistant to degradation of biological fluids. Alternative Names: [DTrp8] Somatostatin; H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: Cys3-Cys14); L-alanyl-glycyl-L-cysteinyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine (3->14)-disulfide; 8-D-tryptophan-somatostatin; 8-Trp-SRIF-14. Grades: ≥95% by HPLC. CAS No. 58976-46-8. Molecular formula: C76H104N18O19S2. Mole weight: 1637.88.
(D-Tyr5,D-Trp6)-LHRH
(D-Tyr5,D-Trp6)-LHRH. Alternative Names: H-Pyr-His-Trp-Ser-D-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. CAS No. 321709-35-7. Molecular formula: C64H82N18O13. Mole weight: 1311.45.
[Fmoc-Lys(Fmoc)]2-Lys-bAla-Wang resin
[Fmoc-Lys(Fmoc)]2-Lys-bAla-Wang resin.
(Fmoc-NH-3,3-Me2-BChept-2-yl)acetic acid(R,S,S)
(Fmoc-NH-3,3-Me2-BChept-2-yl)acetic acid(R,S,S). Alternative Names: [(1R,2S,4S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3,3-dimethylbicyclo[2.2.1]hept-2-yl]acetic acid. CAS No. 1335031-67-8. Molecular formula: C26H29NO4. Mole weight: 419.5.
(Fmoc-NH-6,6-Me2-BChept-2-yl)acetic acid(R,S,S)
(Fmoc-NH-6,6-Me2-BChept-2-yl)acetic acid(R,S,S). Alternative Names: N-Fmoc-[(1R,2S,5S)-2-amino-6,6-dimethylbicyclo[3.1.1]hept-2-yl]acetic acid; [(1R,2S,5S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6,6-dimethylbicyclo[3.1.1]hept-2-yl]acetic acid. CAS No. 1335031-68-9. Molecular formula: C26H29NO4. Mole weight: 419.5.
(Fmoc-NH-7,7-Me2-BChept-3-yl)acetic acid(R,R,S,S)
(Fmoc-NH-7,7-Me2-BChept-3-yl)acetic acid(R,R,S,S). Alternative Names: (1R,3R,4S,6S)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4,7,7-trimethylbicyclo[4.1.0]heptane-3-carboxylic acid. CAS No. 1335034-84-8. Molecular formula: C26H29NO4. Mole weight: 419.5.
(Fmoc-NH-cyclobutyl)acetic acid
(Fmoc-NH-cyclobutyl)acetic acid. Alternative Names: N-Fmoc-2-(1-aminocyclobutyl)acetic acid; (1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}cyclobutyl)acetic acid. CAS No. 1199775-14-8. Molecular formula: C21H21NO4. Mole weight: 351.4.
(Gln22)-Amyloid β-Protein (1-40) is a Dutch mutation (E22Q) of amyloid β-peptide that aggregates more readily than the wild-type peptide, and the resulting fibrils show increased neurotoxicity. At the concentration of 25 μm, the mutant peptide E22Q could induce apoptosis of brain endothelial cells, but WT Aβ 1-40 and the Italian mutant E22K had no significant effect on apoptosis. Alternative Names: Amyloid β-Protein (1-40) E22Q; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine. Grades: ≥95% by HPLC. CAS No. 144410-00-4. Molecular formula: C194H296N54O57S. Mole weight: 4328.82.
(Gln22)-Amyloid β-Protein (1-42)
(Gln22)-Amyloid β-Protein (1-42), the Dutch mutation (E22Q), aggregates more easily than the wild-type. The resulting fibrils show increased neurotoxicity. Alternative Names: Amyloid β-Protein (1-42) Dutch Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine. Grades: ≥90%. CAS No. 147335-12-4. Molecular formula: C203H312N56O59S. Mole weight: 4513.12.
(Gln22,Asn23)-Amyloid β-Protein (1-40)
(Gln22,Asn23)-Amyloid β-Protein (1-40) is a transgenic mice expressing vasculotropic Dutch / Iowa (E693Q/D694N) mutant human brain Aβ precursor protein (TG-SWDI), which accumulates abundant cerebral microvascular fibrillar amyloid deposition and exhibits strong neuroinflammation. In vitro, double-mutated Aβ peptides showed a tendency to increase fibrillation and pathogenicity compared with Dutch and Iowa single mutants. Alternative Names: Amyloid β-Protein (1-40) E22Q/D23N; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asn-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 374796-75-5. Molecular formula: C194H297N55O56S. Mole weight: 4327.82.
[Gln4]-Neurotensin
Neurotensin induces contractions in smooth muscle cells, playing a role in regulating digestive activity in vitro and in vivo. Alternative Names: 4-Gln-neurotensin; H-Pyr-Leu-Tyr-Gln-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH. Grades: 98%. CAS No. 61445-54-3. Molecular formula: C78H122N22O19. Mole weight: 1671.9.
(Glu13.17.20)-Osteocalcin (1-46) (mouse)
Non-carboxylated osteocalcin has been shown to be a bone-specific hormone involved in the regulation of glucose metabolism in which Gla peptide acts as a precursor and transport form. Alternative Names: H-Tyr-Leu-Gly-Ala-Ser-Val-Pro-Ser-Pro-Asp-Pro-Leu-Glu-Pro-Thr-Arg-Glu-Gln-Cys-Glu-Leu-Asn-Pro-Ala-Cys-Asp-Glu-Leu-Ser-Asp-Gln-Tyr-Gly-Leu-Lys-Thr-Ala-Tyr-Lys-Arg-Ile-Tyr-Gly-Ile-Thr-Ile-OH (Disulfide bridge: Cys19-Cys25). Grades: ≥95%. CAS No. 1802086-27-6. Molecular formula: C226H351N57O74S2. Mole weight: 5114.75.
(Glu17.21.24)-Osteocalcin (1-49) (human)
Osteocalcin, a peptide hormone, is not only involved in bone formation but also plays an important role in glucose metabolism and regulates testosterone. In mice, only fully decarboxylated peptides show the latter hormonal activity, whereas osteocalcin, partially decarboxylated osteocalcin, and non-carboxylated peptides appear to be involved in humans. In general, obese individuals have lower levels of osteocalcin than non-obese controls, and individuals with type 2 diabetes have lower plasma osteocalcin than non-diabetic individuals. Alternative Names: Osteocalcin (1-49) (human) (decarboxylated); H-Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Glu-Pro-Arg-Arg-Glu-Val-Cys-Glu-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (Disulfide bridge: Cys23-Cys29). Grades: ≥95%. CAS No. 1927927-11-4. Molecular formula: C266H381N67O76S2. Mole weight: 5797.49.
[Glu1]-Fibrinopeptide B human
[Glu1]-Fibrinopeptide B, generated from fibrinopeptide B amino acid residues 1-14, is used as a mass spec (MS) standard in proteomic research. Alternative Names: [Glu1]-Fibrinopeptide B; H-Glu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-OH; L-alpha-glutamyl-glycyl-L-valyl-L-asparagyl-L-alpha-aspartyl-L-asparagyl-L-alpha-glutamyl-L-alpha-glutamyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-seryl-L-alanyl-L-arginine. Grades: ≥95%. CAS No. 103213-49-6. Molecular formula: C66H95N19O26. Mole weight: 1570.57.