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Esculentin-IGRa
Esculentin-IGRa was found in Rana grahami. It shows antibacterial activity against Gram-negative and Gram-positive bacterial species.
ETD130
ETD130 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=1.56 microg/ml), A. fumigatus GASP4707 (MIC50=25 microg/ml).
ETD131
ETD131 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), A. fumigatus GASP4707 (MIC50=3.125 microg/ml), C. neoformans A (MIC50=12.5 microg/ml).
ETD132
ETD132 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=6.25 microg/ml), A. fumigatus GASP4707 (MIC50=6.25 microg/ml).
ETD133
ETD133 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=6.25 microg/ml), A. fumigatus GASP4707 (MIC50=12.5 microg/ml).
ETD134
ETD134 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=1.56 microg/ml), A. fumigatus GASP4707 (MIC50=3.125 microg/ml).
ETD135
ETD135 is a synthetic construct peptide. It has antifungal activity.
ETD140
ETD140 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), A. fumigatus GASP4707 (MIC50=12.5 microg/ml).
ETD150
ETD150 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), A. fumigatus GASP4707(MIC50=6.25 microg/ml).
ETD151
ETD151 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), C. albicans No. 245962 (MIC50=0.4 microg/ml) , A. fumigatus GASP4707 (MIC50=6.25 microg/ml), C. neoformans A (MIC50=1.56 microg/ml) , F. solani FFUS 8591 (MIC50=0.4 microg/ml) and S. prolificans FSSP 8591 (MIC=0.1 microg/ml).
ETD152
ETD152 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), A. fumigatus GASP4707(MIC50=25 microg/ml).
ETD154
ETD154 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=6.25 microg/ml), A. fumigatus GASP4707(MIC50=12.5 microg/ml).
ETD156
ETD156 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=3.125 microg/ml), A. fumigatus GASP4707(MIC50=25 microg/ml).
ETD179
ETD179 is a synthetic construct peptide. It has antifungal activity against C. albicans IHEM 8060 (MIC50=1.56 microg/ml), A. fumigatus GASP4707 (MIC50=12.5 microg/ml).
Ethyl 3-(Boc-amino)-2,2-difluoropropanoate. Alternative Names: ethyl 3-((tert-butoxycarbonyl)amino)-2,2-difluoropropanoate. CAS No. 847986-13-4. Molecular formula: C10H17F2NO4. Mole weight: 253.24.
Ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate
Ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate (CAS# 640291-92-5 ) is a useful research chemical. Alternative Names: ethyl 5-(4-fluorophenyl)-1,2-oxazole-3-carboxylate. CAS No. 640291-92-5. Molecular formula: C12H10FNO3. Mole weight: 235.21.
Diamines are attached to trityl resins to ensure the minimum of trityl diamine cross-linking. A reagent for solid phase peptide synthesis. Alternative Names: NH2-(CH2)2-NH-Trt-Resin; Diaminoethane-Trt-Resin.
Ethyl malonate monoamide
Ethyl Malonamate can be used for herbicide and herbicide antidote. Alternative Names: Ethyl carbamoylacetate. CAS No. 7597-56-0. Molecular formula: C5H9NO3. Mole weight: 131.13.
ETV6-AML1 fusion protein (332-346)
A peptide fragment of ETV6-AML1 fusion protein. ETV6-AML1 gene fusion is usually an early, prenatal event in childhood acute lymphoblastic leukemia. Alternative Names: ETV6/RUNX1 fusion protein (332-346).
ETV6-AML1 fusion protein (334-342)
A peptide fragment of ETV6-AML1 fusion protein. ETV6-AML1 gene fusion is usually an early, prenatal event in childhood acute lymphoblastic leukemia. Alternative Names: ETV6/RUNX1 fusion protein (334-342).
Eukaryotic initiation factor 4A-III (110-119)
A peptide fragment of Eukaryotic initiation factor 4A-III. It is involved in pre-mRNA splicing as component of the spliceosome. And it is a core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Alternative Names: eIF-4A-III (110-119); ATP-dependent RNA helicase DDX48 (110-119); ATP-dependent RNA helicase eIF4A-3 (110-119).
Eukaryotic translation elongation factor 1 alpha 1 (115-129) is amino acids 115 to 129 fragment of Eukaryotic translation elongation factor 1 alpha 1. This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Alternative Names: Eukaryotic Elongation Factor 1 A-1 (115-129); Leukocyte Receptor Cluster (LRC) Member 7 (115-129).
Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species] TFA is a subunit of Elongation factor 1 that encodes an isomer of the α subunit of the elongation factor-1 complex, responsible for the enzymatic delivery of aminoacyl tRNAs to ribosomes. This subtype (α1) is expressed in the brain, placenta, lungs, liver, kidney, and pancreas, while another subtype (α2) is expressed in the brain, heart, and skeletal muscle. Alternative Names: H-Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu-OH TFA; L-leucyl-L-alpha-glutamyl-L-alpha-aspartyl-glycyl-L-prolyl-L-lysyl-L-phenylalanyl-L-leucine trifluoroacetate salt; THF-γ2 trifluoroacetate salt; Thymic humoral factor-γ2 trifluoroacetate salt; Thymoctonan trifluoroacetate salt. Grades: ≥95%. Molecular formula: C45H68F3N9O15. Mole weight: 1032.07.
Eukaryotic translation initiation factor 4 gamma 1 (1248-1256) is a 9-aa peptide. EIF-4-gamma 1 is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. This peptide can be used in Ovarian carcinoma research. Alternative Names: eIF-4-gamma 1 (1248-1256).
Eukaryotic translation initiation factor 4 gamma 1 (719-727) is a 9-aa peptide. EIF-4-gamma 1 is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. This peptide can be used in Ovarian carcinoma research.
Eumenine mastoparan-AF
Eumenine mastoparan-AF was isolated from the venom of the solitary wasp Anterhynchium flavomarginatum micado, the most common eumenine wasp found in Japan. It is a mast cell degranulating peptide. It has little hemolytic activity. Eumenine mastoparan-AF has an amphiphilic alpha-helix conformation. Eumenine mastoparan-AF shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S.aureus, S.saprophyticus CS (MIC=5 μg/ml), S.epidermidis CS (MIC=5 μg/ml), B.subtilis CCT 2471 (MIC=40 μg/ml), and the Gram-negative bacteria E.coli CCT 1371 (MIC=20 μg/ml), E.coli, and P.aeruginosa. Alternative Names: EMP-AF.
Eumenine mastoparan-EF
Eumenine mastoparan-EF is a linear cationic alpha-helical peptide that acts as an antimicrobial peptide by forming pore in membrane. It has antibacterial activity against both Gram-positive and Gram-negative strains. Eumenine mastoparan-EF has more potent activities against the yeast C.albicans. It shows moderate mast cell degranulation and leishmanicidal activities and has a very low hemolytic activity. Alternative Names: EMP-EF.
Eumenine mastoparan-ER
Eumenine mastoparan-ER is a linear cationic alpha-helical peptide that acts as an antimicrobial peptide by forming pore in membrane. It has antibacterial activity against both Gram-positive and Gram-negative strains. Eumenine mastoparan-ER has more potent activities against the yeast C.albicans. It shows moderate mast cell degranulation and leishmanicidal activities and has a very low hemolytic activity. Alternative Names: EMP-ER.
Eumenine mastoparan-OD
Eumenine mastoparan-OD has potent hemolytic activity against ovine erythrocytes at micromolar concentrations. It also exhibits strong antimicrobial activity against the fungi C.albicans and B.cinerea, and weaker activity against the Gram-negative bacterium E.coli and Gram-positive bacterium S.aureus. Alternative Names: EMP-OD.
Eumenitin
Eumenitin is a cationic linear alpha-helical antimicrobial peptide that binds preferentially to charged lipid membranes as compared with zwitterionic ones. It exhibits inhibitory activity against both Gram-positive and Gram-negative bacteria, and moderately stimulates degranulation from the rat peritoneal mast cells. Eumenitin does not show hemolytic activity. It may play a role in preventing infection by microorganisms during prey consumption by their larvae. Grades: >97% by HPLC. Molecular formula: C78H137N19O19. Mole weight: 1645.03.
Eurocin
Eurocin acts against a range of Gram-positive human pathogens but not against Gram-negative bacteria.
European bumblebee abaecin
European bumblebee abaecin is a Pro-rich peptide. It is active against B. negaterium (MIC=10 ug/ml), E. coli, and A. tumefaciens (25 ug/ml). The source of European bumblebee abaecin is Bombus pascuorum (Hymenoptera, Apoidea). Grades: >98% by HPLC.
Ewing Tumor EZH2 (666-674)
Ewing Tumor EZH2 (666-674) is a peptide corresponding to residues 666-674 of Ewing Tumor EZH2. EZH2 in Ewing sarcoma cells directly binds to the promoter regions of genes encoding for two key enzymes of GD2 biosynthesis, and EZH2 inhibition enhances expression of these genes. Alternative Names: Ewing Tumor Enhancer of Zeste Homolog 2 (666-674).
Exendin-3
Exendin-3 is a bioactive peptide isolated from venoms of the Gila monster lizards, Heloderma horridurn. Alternative Names: H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-glycyl-L-allothreonyl-L-phenylalanyl-L-allothreonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparagyl-glycyl-glycyl-L-prolyl-L-seryl-L-seryl-glycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide. Grades: ≥95%. CAS No. 130357-25-4. Molecular formula: C184H282N50O61S. Mole weight: 4202.57.
Exendin 3 (9-39)
Exendin (9-39) is a specific and competitive glucagon-like peptide-1receptor antagonist (Kd = 1.7 nM at cloned human GLP-1 receptors). Exendin (9-39) inhibits insulin release and cAMP production caused by GLP-1 (7-36), exendin-3, and exendin-4. Alternative Names: Exendin 9-39; Exendin 9 39; H-DL-Asp-DL-Leu-DL-Ser-DL-Lys-DL-Gln-DL-Met-DL-Glu-DL-Glu-DL-Glu-DL-Ala-DL-Val-DL-Arg-DL-Leu-DL-Phe-DL-xiIle-DL-Glu-DL-Trp-DL-Leu-DL-Lys-DL-Asn-Gly-Gly-DL-Pro-DL-Ser-DL-Ser-Gly-DL-Ala-DL-Pro-DL-Pro-DL-Pro-DL-Ser-NH2; DL-alpha-aspartyl-DL-leucyl-DL-seryl-DL-lysyl-DL-glutaminyl-DL-methionyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alpha-glutamyl-DL-alanyl-DL-valyl-DL-arginyl-DL-leucyl-DL-phenylalanyl-DL-isoleucyl-DL-alpha-glutamyl-DL-tryptophyl-DL-leucyl-DL-lysyl-DL-asparagyl-glycyl-glycyl-DL-prolyl-DL-seryl-DL-seryl-glycyl-DL-alanyl-DL-prolyl-DL-prolyl-DL-prolyl-DL-serinamide. Grades: ≥95%. CAS No. 133514-43-9. Molecular formula: C149H234N40O47S. Mole weight: 3369.76.
Exendin-4 (1-8)
Exendin-4 (1-8). Alternative Names: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-NH2; L-Histidylglycyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-serinamide. Grades: ≥95%. CAS No. 1802078-29-0. Molecular formula: C35H51N11O13. Mole weight: 833.84.
EXENDIN-4 (3-39)
Exendin-4 (3-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Alternative Names: H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. Grades: 95%. CAS No. 196109-31-6. Molecular formula: C176H272N46O58S. Mole weight: 3992.44.
Exendin-4 (5-39)
Exendin-4 (5-39) is a potent Glucagon-Like Peptide 1 (GLP-1) receptor antagonist. Alternative Names: H-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2. CAS No. 196109-27-0. Molecular formula: C169H262N44O54S. Mole weight: 3806.30.
Exendin derivative 1
Exendin derivative 1 is a peptide consisting of 39 amino acids. Alternative Names: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-OH; L-histidyl-alanyl-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparagyl-glycyl-glycyl-L-prolyl-L-seryl-L-seryl-glycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serine. Grades: ≥95%. Molecular formula: C184H281N49O61S. Mole weight: 4187.56.
Exherin
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. Alternative Names: NSC729477; ADH-1; NSC7 29477; ADH 1; NSC-729477; ADH1. Grades: 98%. CAS No. 229971-81-7. Molecular formula: C22H34N8O6S2. Mole weight: 570.69.
Exherin trifluoroacetate
Exherin trifluoroacetate is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities, which selectively and competitively binds to and blocks N-cadherin. Alternative Names: ADH-1 trifluroacetate. Grades: >98%. CAS No. 1135237-88-5. Molecular formula: C24H35F3N8O8S2. Mole weight: 684.71.
Eyeliss
Eyeliss is a cosmetic indegredient that has been used to relieve puffiness under eye bags and reduce dark circles beneath the eyes. Grades: 98%.
Ezatiostat
Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Alternative Names: Telintra; Gamma-Glu-S-BzCys-PhGly diethyl ester; TLK-199; TLK 199. CAS No. 168682-53-9. Molecular formula: C27H35N3O6S. Mole weight: 529.652.
FA-Ala-Arg-OH
FA-Ala-Arg-OH is a substrate for human plasma carboxypeptidase N and membrane-bound carboxypeptidase D. Alternative Names: Furylacryloylalanylarginine; Furylacryloyl-alanyl-arginine; L-Arginine, N(2)-(N-(3-(2-furanyl)-1-oxo-2-propenyl)-L-alanyl)-. CAS No. 76079-06-6. Molecular formula: C16H23N5O5. Mole weight: 365.38.
Fa-AMP1
Fa-AMP1 is produced by Fagopyrum esculentum. The concentration of peptide required for 50% inhibition (IC50) of the growth of plant pathogenic fungi, and Gram-positive and -negative bacteria is 11 to 36 microg/ml. Mole weight: 3879.
Fa-AMP2
Fa-AMP2 is produced by Fagopyrum esculentum. The concentration of peptide required for 50% inhibition (IC50) of the growth of plant pathogenic fungi, and Gram-positive and -negative bacteria is 11 to 36 microg/ml. Mole weight: 3906.
Fabatin-1
Fabatin-1 is active against both Gram-negative and Gram-positive bacteria, but is inactive against the yeasts Saccharomyces cerevisiae and Candida albicans.
Fabatin-2
Fabatin-2 is active against both Gram-negative and Gram-positive bacteria, but is inactive against the yeasts Saccharomyces cerevisiae and Candida albicans.
FA-Glu-Glu-OH
FA-Glu-Glu-OH is the preferred substrate for carboxypeptidase O in humans and zebrafish. Alternative Names: N-[(2E)-3-(2-Furyl)-2-propenoyl]-L-α-glutamyl-L-glutamic acid; L-Glutamic acid, N-[(2E)-3-(2-furanyl)-1-oxo-2-propen-1-yl]-L-α-glutamyl-; (S)-2-((S)-4-carboxy-2-((E)-3-(furan-2-yl)acrylamido)butanamido)pentanedioic acid; FA-EE-OH. Grades: ≥90%. CAS No. 1374423-90-1. Molecular formula: C17H20N2O9. Mole weight: 396.35.
FA-Gly-Abu-NH2
FA-Gly-Abu-NH2 can be used as substrate in a substrate specificity study of thermolysin. Alternative Names: 3-(2-Furyl)acryloyl-Gly-Abu-NH2. Grades: ≥ 98%. CAS No. 67607-48-1. Molecular formula: C13H17N3O4. Mole weight: 279.30.
FA-Gly-Leu-NH2
FA-Gly-Leu-NH2. Alternative Names: (3-[2-Furyl]acryloyl)-Gly-Leu amide; (S,E)-2-(2-(3-(furan-2-yl)acrylamido)acetamido)-4-methylpentanamide; FAGLA. Grades: >99%. CAS No. 26400-33-9. Molecular formula: C15H21N3O4. Mole weight: 307.34.
Fa-Gly-OH
Fa-Gly-OH. Alternative Names: (E)-2-(3-(Furan-2-yl)acrylamido)acetic acid; Furanacryloylglycine; Fa Gly OH. Grades: 95%. CAS No. 124882-74-2. Molecular formula: C9H9NO4. Mole weight: 195.17.
FA-Gly-Phe-Leu-OH
FA-Gly-Phe-Leu-OH. CAS No. 390766-88-8. Molecular formula: C24H29N3O6. Mole weight: 455.50.
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.
Fallaxidin-3.1
Fallaxidin-3.1 was found in Litoria fallax. It has antibacterial activity.
Fallaxidin 3.2
Fallaxidin 3.2 has antibacterial activity. Fallaxidin 3.2 was found in Litoria fallax [Eastern dwarf tree frog].
Fallaxidin 4.1
Fallaxidin 4.1 was found in Litoria fallax. Fallaxidin 4.1 has antibacterial activity against L.lactis (MIC = 12 microM), M.luteus (MIC = 100 microM), S.epidermidis (MIC = 100 microM), and S.uberis (MIC = 50 microM).
Fanconi anemia group M protein (201-214)
Fanconi anemia group M protein (201-214) is a bioactive peptide of Fanconi anemia group M protein. It is believed that FACM in conjunction with other Fanconi anemia- proteins repair DNA at stalled replication forks, and stalled transcription structures called R-loops. Alternative Names: Protein FACM (201-214); ATP-dependent RNA helicase FANCM (201-214).
FA-Phe-Ala-OH
FA-Phe-Ala-OH. Alternative Names: Furylacryloyl-L-phenylalanyl-L-alanine. CAS No. 83803-17-2. Molecular formula: C19H20N2O5. Mole weight: 356.37.
FA-PHE-PHE-OH
A substrate for a sensitive spectrophotometric assay of serum carboxypeptidase A. Alternative Names: N-(3-[2-Furyl]acryloyl)-Phe-Phe; FAPP; Furylacryloyl-Phe-Phe; (S)-2-((S)-2-((E)-3-(furan-2-yl)acrylamido)-3-phenylpropanamido)-3-phenylpropanoic acid. CAS No. 83661-95-4. Molecular formula: C25H24N2O5. Mole weight: 432.47.
FAST kinase domain-containing protein 1 isoform 1 (497-514)
FAST kinase domain-containing protein 1 isoform 1 (497-514) is a peptide derived from FAST kinase domain-containing protein 1 isoform 1. FAST kinase domain-containing protein 1 is involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity.
FATGIGIITV
FATGIGIITV is a peptide fragment which acts as a superagonist.
F-box protein FBL5 (227-255)
F-box protein FBL5 (227-255) is a peptide corresponding to residues 227-255 of F-box protein FBL5. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.