BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
One of the impurities of Tacrolimus, which is a kind of immunosuppressant and could restrain the activity of FK-506 binding protein. Synonyms: Tacrolimus Impurity 2; Tacrolimus Regioisomer; Tacrolimus Allylic Ester Rearrangement Impurity. Grade: 95%. CAS No. 131944-48-4. Molecular formula: C44H69NO12. Mole weight: 804.02.
(E/Z)-GO289
(E/Z)-GO289 is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM. Synonyms: STK980186; GO289; GO-289; GO 289. CAS No. 694522-87-7. Molecular formula: C17H15BrN4O2S. Mole weight: 419.30.
(E/Z)-GSK-3β inhibitor 1
(E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-(2-Pyridinylmethylene)-indolin-2-one; 3-(2-Pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-. Grade: ≥98%. CAS No. 3367-88-2. Molecular formula: C14H10N2O. Mole weight: 222.24.
(E/Z)-GSK5182
GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma. Synonyms: Benzenebutanol, δ-[[4-[2-(dimethylamino)ethoxy]phenyl](4-hydroxyphenyl)methylene]-; δ-[[4-[2-(Dimethylamino)ethoxy]phenyl](4-hydroxyphenyl)methylene]benzenebutanol; Gsk5182(Z/E); 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol. Grade: 98%. CAS No. 2699724-40-6. Molecular formula: C27H31NO3. Mole weight: 417.54.
(E/Z)-IT-603
(E/Z)-IT-603 is a mixture of (E)-IT-603 and (Z)-IT-603. IT-603 is a NF-κB family member c-Rel inhibitor with IC50 of 3 μM. Synonyms: IT-603. CAS No. 292168-90-2. Molecular formula: C11H9BrN2O3S. Mole weight: 329.17.
(E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen
A metabolite of Tamoxifen. Tamoxifen is a selective estrogen receptor modulator (SERM) widely used in breast cancer treatment and prevention, particularly for estrogen receptor-positive (ER+) tumors. It works by competitively blocking estrogen receptors in breast tissue, inhibiting cancer cell growth. Synonyms: 4-[1-[4-(2-Aminoethoxy)phenyl]-2-phenyl-1-buten-1-yl]phenol; 4-{1-[4-(2-Aminoethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenol; (E/Z)-Tamoxifen N,N-Didesmethyl 4-Hydroxy; Tamoxifen Citrate Impurity 28. Grade: 95%. CAS No. 1217237-98-3. Molecular formula: C24H25NO2. Mole weight: 359.46.
(E/Z)-Sivopixant
(E/Z)-Sivopixant is a potent P2X3 receptor antagonist with an IC50 of 4 nM. It can be used for respiratory diseases research. Synonyms: (E/Z)-S-600918. Grade: 98%. CAS No. 1640808-39-4. Molecular formula: C25H22ClN5O5. Mole weight: 507.93.
(E/Z)-Tamoxifen
A mixed form of Tamoxifen. Tamoxifen is a selective estrogen receptor modulator (SERM) widely used in breast cancer treatment and prevention, particularly for estrogen receptor-positive (ER+) tumors. It works by competitively blocking estrogen receptors in breast tissue, inhibiting cancer cell growth. Uses: Mixture of tamoxifen and its (e)-isomer. Synonyms: (E,Z)-Tamoxifen; (E/Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; 1-[p-[2-(N,N-Dimethylamino)ethoxy]phenyl]-1,2-diphenylbut-1-ene; (E/Z)-Mammaton; (E/Z)-Novaldex; 2-[4-(1,2-Diphenyl-1-buten-1-yl)phenoxy]-N,N-dimethylethanamine; 2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; 2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Grade: ≥95%. CAS No. 7728-73-6. Molecular formula: C26H29NO. Mole weight: 371.51.
(E/Z)-Trelnarizine Hydrochloride
It is an antihistamine and vasodilator with calcium antagonist activity. Uses: It is a vasodilator in rats and rabbits with activity comparable to that of flunarizine (f455200) and inhibited blood platelet aggregation more effectively than acetylsalicylic acid. Synonyms: Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-(3,4-dimethoxyphenyl)-2-propenyl)-, dihydrochloride; 1-[Bis(4-fluorophenyl)methyl]-4-[3-(3,4-dimethoxyphenyl)-2-propenyl]piperazine Dihydrochloride; PU 122. Grade: ≥95%. CAS No. 99661-27-5. Molecular formula: C28H32Cl2F2N2O2. Mole weight: 537.47.
[Gln8]-C517 (LH-RH), chicken acetate
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions. Molecular formula: C56H75N15O16. Mole weight: 1214.31.
(Glp1)-Apelin-13 trifluoroacetate salt
The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 , apelin-17, and apelin-13, respectively. Synonyms: (pGlu1)Apelin-13; Pyr-Apelin-13; (Pyr1)Apelin-13; 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine trifluoroacetate salt. Grade: ≥95%. Molecular formula: C69H108N22O16S·xCF3COOH. Mole weight: 1533.80.
[Glu(4)-Gly-OH]-AVP
[Glu(4)-Gly-OH]-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: Glu(4)-Gly-OH-Vasopressin; H-Cys-Tyr-Phe-Glu-Asn-Cys-Pro-Arg-Gly-OH (Disulfide bridge: Cys1-Cys6); L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-α-glutamyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginyl-glycine (1->6)-disulfide. Molecular formula: C46H63N13O14S2. Mole weight: 1086.21.
[Gly-NH2-Ac]9-Argipressin
An impurity of Vasopressin. Vasopressin is a nonapeptide hormone produced in the hypothalamus and released by the posterior pituitary gland. It is used clinically to manage central diabetes insipidus, treat hypotension in shock, and control gastrointestinal bleeding. Synonyms: Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2-Ac(Cys1&Cys6 bridge); CYFQNCPRG-NH2-Ac(Cys1&Cys6 bridge); H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2-Ac (Disulfide bridge: Cys1-Cys6); L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginyl-N-acetyl-glycinamide (1->6)-disulfide; Ac-Argipressin; [Gly9-NH2-Ac]-Argipressin; [Gly-NH2-Ac]9-Arginine-vasopressin. Grade: ≥95%. Molecular formula: C48H67N15O13S2. Mole weight: 1126.28.
[Gly-ol]9-Atosiban
An impurity of Atosiban. Atosiban is a synthetic peptide that acts as a selective oxytocin receptor antagonist, primarily used to delay preterm labor in pregnant women. Synonyms: Mpr-DTyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-ol(Mpr1Cys6 bridge); Atosiban impurity 11; Gly9-ol-Atosiban; [Gly9-ol]-Atosiban; deamino-Cys-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-ol (Disulfide bridge: Cys1-Cys6); Deamino-cysteinyl-O4-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparagyl-L-cysteinyl-L-prolyl-L-ornithyl-glycinol (1->6)-disulfide. Grade: ≥95%. Molecular formula: C43H68N10O12S2. Mole weight: 981.19.
[H2N-D-Nal2]-Cetrorelix
[H2N-D-Nal2]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: H2N-D-Nal2-Cetrorelix; Ac-D-2Nal(NH2)-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2. Molecular formula: C70H93ClN18O14. Mole weight: 1446.08.
[hydroxymethyl-D-Trp4]-octreotide
[hydroxymethyl-D-Trp4]-octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: N1.4-(Hydroxymethyl)octreotide; Octreotide EP Impurity C; [N-hydroxymethyl-D-Trp4]-octreotide; H-D-Phe-Cys(1)-Phe-D-Trp(CH2OH)-Lys-Thr-Cys(1)-Thr-ol; H-D-Phe-Cys-Phe-D-Trp(CH2OH)-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7); D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-N-hydroxymethyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol (2->7)-disulfide. Grade: ≥95%. CAS No. 1546983-16-7. Molecular formula: C50H68N10O11S2. Mole weight: 1049.27.
(Hydroxypropyl)methyl cellulose
In oral products, (hydroxypropyl)methyl cellulose is mainly used as a tablet binder, film coating agent and matrix for use in extended release tablet formulations. It is also used as a suspending agent and/or thickener in liquid oral dosage forms and topical preparations. It is also used in the manufacture of capsules, as an adhesive for plastic bandages and as a wetting agent for hard contact lenses. Synonyms: Cellulose hydroxypropyl methyl ether; Hypromellose; Benecel MHPC; E464; hydroxypropyl methylcellulose; HPMC; hypromellosum; Methocel; methylcellulose propylene glycol ether; methyl hydroxypropylcellulose; Metolose; MHPC; Pharmacoat; Tylopur; Tylose MO. CAS No. 9004-65-3.
(Hydroxypropyl)methyl cellulose phthalate
(Hydroxypropyl)methyl cellulose phthalate is widely used in oral preparations as an enteric coating material for tablets or granules. Synonyms: Cellulose, hydrogen 1,2-benzenedicarboxylate, 2-hydroxypropyl methyl ether; Hypromellose Phthalate; Cellulose phthalate hydroxypropyl methyl ether; HPMCP; Hydroxypropyl methylcellulose benzene-1,2-dicarboxylate; 2-Hydroxypropyl methylcellulose phthalate; Mantrocel HP-55; Methylhydroxypropylcellulose phthalate; 2-Hydroxypropyl methyl cellulose phthalate; Cellulose methyl 2-hydroxypropyl ether hydrogen phthalate ester; Glycidyl methacrylate-HPMCP copolymer. CAS No. 9050-31-1.
[Hyp3]-Bradykinin
(Hyp3)-Bradykinin is an agonist of bradykinin B2 receptor and interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts. Synonyms: Bradykinin hydroxyproline; Arg-3-hyp-bradykinin; 3-Hydroxy-pro-bradykinin; 3-(L-4-Hydroxyproline)bradykinin; Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg. CAS No. 37642-65-2. Molecular formula: C50H73N15O12. Mole weight: 1076.21.
(Hyp3)-Bradykinin acetate
(Hyp3)-Bradykinin acetate is an agonist of bradykinin B2 receptor and interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts. Molecular formula: C52H77N15O14. Mole weight: 1136.26.
[Leu31,Pro34] Neuropeptide Y (human) trifluoroacetate salt
[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5. Synonyms: [Leu31,Pro34] NPY; [Leu31,Pro34]-NPY (human). Grade: ≥95%. Molecular formula: C189H284N54O56S·xCF3COOH. Mole weight: 4240.67.
[Leu5]-Enkephalin acetate
Leu5]-Enkephalin is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Synonyms: Leu-Enkephalin Acetate; Tyr-Gly-Gly-Phe-Leu acetate salt. CAS No. 81678-16-2. Molecular formula: C30H41N5O9. Mole weight: 615.67.
An impurity of Nefopam, which is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. Synonyms: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine 5-Oxide- d4. Grade: > 95%. Molecular formula: C17H15NO2D4. Mole weight: 273.37.
(lR,5R)/(lS,5S)-Nefopam N-Oxide
An impurity of Nefopam, which is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. Synonyms: Nefopam N-Oxide; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine 5-Oxide. Grade: > 95%. CAS No. 66091-32-5. Molecular formula: C17H19NO2. Mole weight: 269.35.
(lR,5S)/(lS,5R)-Nefopam N-Oxide
An impurity of Nefopam, which is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. Synonyms: (lR,5S)/(lS,5R)-3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine 5-Oxide. Grade: > 95%. Molecular formula: C17H19NO2. Mole weight: 269.35.
[Lys5(Ac)]-Lanreotide
[Lys5(Ac)]-Lanreotide is an impurity of Lanreotide, which is a somatostatin analogue with antineoplastic activity. Synonyms: Lys-(Ac)5 Lanreotide; (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(4-acetamidobutyl)-19-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-16-(4-hydroxybenzyl)-7-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide. CAS No. 1353092-24-6. Molecular formula: C56H71N11O11S2. Mole weight: 1138.36.
[Lys5,?MeLeu9,?Nle10]?-?Neurokinin A (4-10) Fragment
[Lys5,MeLeu9,Nle10]-Neurokinin A (4-10) Fragment is a neurokinin A derivative. It is an NK2 agonist with IC50 value of 6.1 nM. It can induce contraction in smooth muscle cells of rodents. Synonyms: (3S,6S,9S,12S,18S,21S)-3-Amino-6-(4-aminobutyl)-9-benzyl-21-carbamoyl-18-isobutyl-12-isopropyl-17-methyl-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosan-1-oic acid. Grade: ≥95% by HPLC. CAS No. 137565-28-7. Molecular formula: C39H65N9O9. Mole weight: 804.
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA
It is a highly selective and potent NK2 receptor agonist with an IC50 of 6.1 nM. Molecular formula: C41H66F3N9O11. Mole weight: 918.01.
(Lys8,Lys9)-Neurotensin (8-13)
[Lys8, Lys9]-Neurotensin (8-13) is a neurotensin analog. It exerts analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively. Synonyms: JMV438. CAS No. 139026-64-5. Molecular formula: C38H64N8O8. Mole weight: 760.96.
[Met5]-Enkephalin, amide TFA
It is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors. Synonyms: 5-Methionine-enkephalin amide TFA; H-Tyr-Gly-Gly-Phe-Met-NH2 TFA; L-Tyrosylglycylglycyl-L-phenylalanyl-L-methioninamide TFA; BI 251 TFA; Met5-enkephalin amide TFA; Methionine enkephalin amide TFA; Tyr-Gly-Gly-Phe-Met-NH2 TFA; YGGFM-NH2 TFA. Grade: 99%. CAS No. 2918768-28-0. Molecular formula: C29H37F3N6O8S. Mole weight: 686.70.
[Met(O)18,Ser(tBu)1]-Teriparatide
[Met(O)18,Ser(tBu)1]-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: Met(O)18,Ser(tBu)1-Teriparatide; O-tert-butyl-L-seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl(O)-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; H-Ser(tBu)-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met(O)-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Molecular formula: C185H299N55O52S2. Mole weight: 4189.88.
[Met(O)18]-Teriparatide
[Met(O)18]-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: Teriparatide Impurity 3 (Teri-Met 18(O)); L-seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl(O)-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; Met(O)18-Teriparatide; H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met(O)-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Molecular formula: C181H291N55O52S2. Mole weight: 4133.77.
[Met(O)-8,18]-Teriparatide
[Met(O)-8,18]-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: L-Seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl(O)-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl(O)-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; Teriparatide Impurity-1 (Teri-Met. CAS No. 96420-15-4. Molecular formula: C181H291N55O53S2. Mole weight: 4149.77.
[Met(O)8,Ser(tBu)1]-Teriparatide
[Met(O)8,Ser(tBu)1]-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: Met(O)8,Ser(tBu)1-Teriparatide; O-tert-butyl-L-seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl(O)-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; H-Ser(tBu)-Val-Ser-Glu-Ile-Gln-Leu-Met(O)-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Molecular formula: C185H299N55O52S2. Mole weight: 4189.88.
[Met(O)8]-Teriparatide
[Met(O)8]-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: Teriparatide Impurity 2 (Teri-Met 8(O)); L-seryl-L-valyl-L-seryl-L-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl(O)-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl-L-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine; Met(O)8-Teriparatide; H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met(O)-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Molecular formula: C181H291N55O52S2. Mole weight: 4133.77.
[μ-(7-Hydroxy-3-oxo-3H-phenoxazine-4,6-diyl)]bis(2,2,2-trifluoroacetato-κO)di-mercury is an intermediate in the synthesis of ReAsH-EDT2, which is a membrane-permeable fluorescent probe for labeling tetracysteine sequences in target proteins. Synonyms: [mu-(7-Hydroxy-3-oxo-3H-phenoxazine-4,6-diyl)]bis(2,2,2-trifluoroacetato)dimercury; Mercury, [μ-(7-hydroxy-3-oxo-3H-phenoxazine-4,6-diyl)]bis(2,2,2-trifluoroacetato-κO)di-. Grade: ≥95%. CAS No. 1073288-58-0. Molecular formula: C16H5F6Hg2NO7. Mole weight: 838.38.
(N4-Benzoyl)-5'-O-[(N,N-Diisopropylamino)-(2-Cyanoethoxy)phosphinyl]-3'-O-(4,4'-Dimethoxytrityl)-2'-Deoxycytidine, a sophisticated and multifunctional compound at the forefront of biomedical advancements, encompasses a pivotal role in the realm of biomedicine. It stands as an indispensable agent in the combat against an array of ailments. Synonyms: ((2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-3-(bis(4-methoxyphenyl)(phenyl)methoxy)tetrahydrofuran-2-yl)methyl (2-cyanoethyl) diisopropylphosphoramidite; Cytidine,N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethylbis(1-methylethyl)phosphoramidite]. Grade: 95%. CAS No. 140712-83-0. Molecular formula: C46H52N5O9P. Mole weight: 849.91.
(N,4-O)-Diacetyl-D-Glucosamine
A diacetylated analogue of D-Glucosamine. Synonyms: 2-(Acetylamino)-2-deoxy-D-glucose 4-Acetate; D-Glucosamine (N,4-O)-Diacetate; N-Acetyl Glucosamine 4-Acetate; (N,4-O)-Diacetyl-D-Glucosamin. Molecular formula: C10H17NO7. Mole weight: 263.24.
(N6-Benzoyl)-5'-O-[(N,N-diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine is a modified phosphoramidite used in oligonucleotide synthesis. This compound includes protective groups such as dimethoxytrityl (DMT), benzoyl (Bz), and cyanoethyl (CE). These protective groups play a crucial role in the synthesis process, ensuring correct assembly and sequence synthesis of nucleotides, particularly in reverse synthesis (from the 5' to 3' end). Synonyms: Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N4-benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-5'-cyanoethyl Phosphoramidite; DMT-dA(Bz)-5'-CE Reverse Phosphoramidite; 3'-DMT-dA(Bz)-CE Reverse; 3'-O-DMTr-dA(Bz)-5'-CE-Phosphoramidite; DMT-dA(Bz)-CE Inverted Phosphoramidite; N6-benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-5'-cyanoethyl Phosphoramidite. Grade: 95%. CAS No. 140712-82-9. Molecular formula: C47H52N7O7P. Mole weight: 857.93.
[Nle4,D-Phe7]-α-MSH trifluoroacetate salt
[Nle4,D-Phe7]-α-MSH is a synthetic analog of α-melanocyte stimulating hormone (α-MSH). Synonyms: [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt. Grade: ≥95%. Molecular formula: C78H111N21O19·xCF3COOH. Mole weight: 1646.85.
(N-Methyl-Leu) Vancomycin B
An impurity of Vancomycin. Vancomycin is a glycopeptide antibiotic for the treatment of gram-positive bacteria. Vancomycin exhibits an antibacterial effect by inhibiting bacterial cell wall synthesis. Molecular formula: C67H77Cl2N9O24. Mole weight: 1463.31.
(N,N-Dimethylcarbamimidoyl)urea
(N,N-Dimethylcarbamimidoyl)urea is an impurity of metformin, a first-line drug for the treatment of type 2 diabetes. Synonyms: N,N-Dimethylamidino Urea; N3-Desamidino; N3-carbamoyl Metformin. CAS No. 98026-16-5. Molecular formula: C4H10N4O. Mole weight: 130.15.
(N-O) acyl isomer of Octreotide
(N-O) acyl isomer of Octreotide is an impurity of Octreotide, which is a synthetic long-acting cyclic octapeptide used as a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Synonyms: D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-(2S,3R)-3-aminobutane-1,2-diol (Disulfide Bridge between Cys2-Cys7); D-phenylalanyl-L-cystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cystyl-(2S,3R)-3-aminobutane-1,2-diol (Disulfide Bridge between Cys2-Cys7). Molecular formula: C49H66N10O10S2. Mole weight: 1019.25.
[Nphe1]Nociceptin(1-13)NH2
[Nphe1]Nociceptin(1-13)NH2 acts as the first truly selective and competitive nociceptin receptor antagonist and is devoid of any residual agonist activity. It binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo. Synonyms: (S,Z)-6-amino-N-((S,Z)-1-(((S,Z)-1-(((S,Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1,3-dihydroxypropan-2-yl)-2-((Z)-((4Z,7Z,10Z,12S,13Z,15S,16Z,19Z,21S,22Z,24S)-12-benzyl-24-(3. CAS No. 267234-08-2. Molecular formula: C61H100N22O15. Mole weight: 1381.6.
[Nphe1]Nociceptin(1-13)NH2 TFA
[Nphe1]Nociceptin(1-13)NH2 is a novel nociceptin/orphanin FQ (NC) endogenous ligand. It is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi = 8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2 = 6.0). Molecular formula: C63H101F3N22O17. Mole weight: 1495.61.
[Orn5]-URP acetate
[Orn5]-URP is a urotensin-II (UT) receptor pure antagonist (pEC50 = 7.24) that displays no agonist activity unlike other U-II/URP analogs. [Orn5]-URP has been shown to inhibit the action of U-II in the rat aorta ring assay. Synonyms: [Orn5]-URP acetate; AKOS040764147. Molecular formula: C50H66N10O12S2. Mole weight: 1063.25.
[Orn8]-Urotensin II (human) trifluoroacetate salt
[Orn8]-Urotensin II is a peptide analog of urotensin II and agonist of the urotensin II receptor. Synonyms: L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5→10)-disulfide, trifluoroacetate salt. Grade: ≥95%. Molecular formula: C63H83N13O18S2·xCF3COOH. Mole weight: 1374.54.
[(pF)Phe4]Nociceptin(1-13)NH2
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80), with 8000-fold selectivity over δ, κ, and μ opioid receptors. Synonyms: (S,Z)-6-amino-N-((S,Z)-1-(((S,Z)-1-(((S,Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1,3-dihydroxypropan-2-yl)-2-((Z)-((2S,3Z,5S,6Z,9Z,11S,12Z,14S,15Z,18Z,21Z,23S)-23-amino-2-(3-. CAS No. 380620-88-2. Molecular formula: C61H99FN22O15. Mole weight: 1399.6.
[(pF)Phe4]Nociceptin(1-13)NH2 TFA
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50=9.80). It displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo. Molecular formula: C63H100F4N22O17. Mole weight: 1513.60.
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 is the first selective antagonist to prevent the binding of the endogenous ligand orphanin FQ?/Nociceptin (OFQ?/N) at the orphan opioid-like receptor, demonstrated both in vitro and in vivo. It is selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively). Synonyms: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide; N-[(2S)-2-Amino-3-phenylpropyl]glycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide; N-[(2S)-2-Amino-3-phenylpropyl]-13-L-lysinamide-2-13-orphanin FQ (swine). CAS No. 213130-17-7. Molecular formula: C61H102N22O14. Mole weight: 1367.6.
[Phe(4-Cl)2]-Cetrorelix
[Phe(4-Cl)2]-Cetrorelix is a derivative of Cetrorelix, a gonadotropin-releasing hormone antagonist that can be used in the treatment of prostate and breast cancers. Synonyms: Phe(4-Cl)2-Cetrorelix; Ac-D-2Nal-D-Phe(4-Cl)-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2. Molecular formula: C79H100Cl2N18O15. Mole weight: 1612.68.
[Phe8Y(CH-NH)Arg9]-Bradykinin
[Phe8Y(CH-NH)Arg9]-Bradykinin is a selective bradykinin B2 receptor agonist with 5-fold potency against bradykinin in vivo. It is resistant to carboxypeptidase cleavage. Uses: Hypotensive agent. Synonyms: Ppcna-BK; 8-Phe-9-psi-CH2NH-arg-bradykinin. CAS No. 118122-39-7. Molecular formula: C50H75N15O10. Mole weight: 1046.23.
(Piperidine-2,6-dione-4-yl)b-D-ribofuranoside
(Piperidine-2,6-dione-4-yl)b-D-ribofuranoside, titled stands out as a captivating compound in the realm of biomedical research. Within the context of combating multifarious ailments, predominantly cancer, this compound exhibits a myriad of salient features attributed to its distinct molecular structure. Foreseen as a beacon of hope, it holds immense promise in revolutionizing targeted drug delivery systems. Synonyms: (Piperidine-2,6-dione-4-yl)-β-D-ribofuranoside. Molecular formula: C10H15NO7. Mole weight: 261.23.
[P(R)]-3'-O-[(1,1-Dimethylethyl)dimethylsilyl]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3'→5')-2'-deoxy-2'-fluoro-, cyclic nucleotide, adenosine, ammonium (1:2) is a potent nucleotide analog used as a therapeutic intervention for the treatment of cancers attributed to abnormal activation of the Ras signaling pathway, including lung cancer and pancreatic cancer. Its mechanism of action involves targeted inhibition of the overactive Ras protein, frequently mutated in these malignancies to curtail pathogenesis. Molecular formula: C26H43FN12O9P2S2Si. Mole weight: 840.86.
[Pro3]-GIP (Mouse)
[Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50 = 2.6μM). It suppresses GIP-stimulated insulin release from pancreatic β cells in vitro. It blocks the effects of GIP on insulin release and plasma glucose levels in ob/ob mice. Grade: ≥97%. Molecular formula: C225H342N62O64S. Mole weight: 4971.62.
[Pro3]-GIP (Rat)
[Pro3]-GIP (Rat) is a high affinity partial agonist at rat GIP receptor (Kd = 13 nM). It increases cAMP accumulation in COS-7 cells transfected with rat GIP receptor, while also acting as a competitive antagonist of GIP. Grade: ≥95%. Molecular formula: C226H343N61O64S. Mole weight: 4970.63.
(R)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt
(R)-10-Monohydroxy-10,11-dihydro Carbamazepine O-β-D-Glucuronide Sodium Salt is a metabolite of Carbamazepine, which is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. Synonyms: (10R)-5-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; (R)-(Aminocarbonyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-yl β-D-Glucopyranosiduronic Acid Sodium Salt; R-Licarbazepine Glucuronide Sodium Salt. Grade: ≥95%. Molecular formula: C21H21N2NaO8. Mole weight: 452.39.
(R)-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid is an isomer of Montelukast, which is a leukotriene receptor antagonist indicated for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, (R)-; {1-[({(1R)-1-{3-[2-(7-Chloro-2-quinolinyl)vinyl]phenyl}-3-[2-(2-hydroxy-2-propanyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid. Grade: 95%. CAS No. 142522-28-9. Molecular formula: C35H36ClNO3S. Mole weight: 586.19.
(R)-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt
(R)-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt is an isomer of Montelukast, which is a leukotriene receptor antagonist indicated for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-, monosodium salt, (R)-; sodium (R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate. Grade: 95%. CAS No. 142522-81-4. Molecular formula: C35H35ClNNaO3S. Mole weight: 609.18.
(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. CAS No. 1370190-85-4. Molecular formula: C14H13F2N3O. Mole weight: 277.27.
(R)-1-(2-((2,6-Dimethylphenyl)amino)-2-oxoethyl)-4-(2-hydroxy-3-(2-methoxy-6-(trifluoromethyl)phenoxy)propyl)piperazin-1-ium is one of Ranolazine impurities. Ranolazine is an anti-ischemic agent which modulates myocardial metabolism. Molecular formula: C25H33F3N3O4?. Mole weight: 496.54.
(R)-1-(2-hydroxyacetyl)pyrrolidine-2-carbonitrile
(R)-1-(2-hydroxyacetyl)pyrrolidine-2-carbonitrile is an impurity of Vildagliptin. It is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Synonyms: Vildagliptin Impurity 57. Molecular formula: C7H10N2O2. Mole weight: 154.17.
(R)-(+)-1-(2-Naphthyl)ethylamine
(R)-(+)-1-(2-Naphthyl)ethylamine is a chiral resolution reagent to separate racemic compounds into different mirror isomers and is an important tool for the production of optically active drugs. Synonyms: Cinacalcet 6-Ethanamine Impurity; (αR)-α-Methyl-2-naphthalenemethanamine; (+)-1-(2-Naphthyl)ethylamine; (+)-α-(2-Naphthyl)ethylamine; (+)-α-Methyl-2-naphthalenemethylamine; (R)-(+)-1-(2-Naphthyl)ethylamine. Grade: >98.0%(GC)(T). CAS No. 3906-16-9. Molecular formula: C12H13N. Mole weight: 171.24.
An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity YX. Grade: ≥95%. CAS No. 1288338-95-3. Molecular formula: C24H24N6O2. Mole weight: 428.49.
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: (αR)-α-methyl-3,5-bis(trifluoromethyl)-Benzenemethanol; (+)-(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethanol. Grade: ≥95%. CAS No. 127852-28-2. Molecular formula: C10H8F6O. Mole weight: 258.16.
(R)-1,4-Anhydro-2-O-(2,4-dimethoxybenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-sulfinyl-D-ribitol, an intriguing biomedicine, exhibits potent therapeutic potential in diverse cancer types. Through its inhibition of specific molecular pathways crucial for tumor growth and progression, this compound emerges as a promising and targeted anti-cancer agent. The intricate arrangement of its structure confers remarkable selectivity towards malignant cells, fueling optimism for its application in tailored and effective cancer therapies. Synonyms: D-Ribitol, 1,4-dideoxy-1,4-(R)-episulfinyl-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-, 2,4-dimethoxybenzoate. CAS No. 291758-13-9. Molecular formula: C26H44O8SSi2. Mole weight: 572.86.
One impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Synonyms: Tenofovir impurity Q. CAS No. 1643116-24-8. Molecular formula: C9H14N5O4P. Mole weight: 287.22.
One impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Synonyms: Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (2E)-2-butenedioate; Tenofovir impurity 23. CAS No. 1236287-05-0. Molecular formula: C13H18N5O8P. Mole weight: 403.28.