BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Bazedoxifene-5-Glucuronide | Bazedoxifene-5-Glucuronide is a metabolite of Bazedoxifene. Synonyms: Bazedoxifene 5-β-D-Glucuronide; 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-yl β-D-Glucopyranosiduronic Acid. Grade: 95%. CAS No. 328933-56-8. Molecular formula: C36H42N2O9. Mole weight: 646.74. |  |
| Bazedoxifene acetate | Bazedoxifene acetate, also called as TSE424 or WAY-140424, is a selective nonsteroidal estrogen receptor modulator (SERM) with antiosteoporotic activity (ERα: IC50= 26 nM; ERβ= 99 nM). Uses: Bone density conservation agents. Synonyms: TSE 424; TSE-424; TSE424; WAY-140424; WAY 140424; WAY140424. Grade: 98%. CAS No. 198481-33-3. Molecular formula: C32H38N2O5. Mole weight: 530.66. | |
| Bazedoxifene hydrochloride | Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene does not stimulate ERα mediated transcriptional activity and acts as an antagonist to estradiol in cultured breast cancer (bMCF-7) cells. Uses: Bone density conservation agents. Synonyms: TSE-424 hydrochloride; 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol hydrochloride; 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1). Grade: >98%. CAS No. 198480-56-7. Molecular formula: C30H34N2O3.HCl. Mole weight: 507.06. | |
| Bazedoxifene Impurity 3 | Bazedoxifene Impurity 3 is a metabolite of Bazedoxifene. Synonyms: Des(1-azepanyl)ethyl Bazedoxifene; 2-(4-Hydroxyphenyl)-1-[(4-hydroxyphenyl)methyl]-3-methyl-1H-Indol-5-ol; 1-(4-Hydroxybenzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol. Grade: > 95%. CAS No. 104599-10-2. Molecular formula: C22H19NO3. Mole weight: 345.40. | |
| Bazedoxifene Impurity 4 | Bazedoxifene Impurity 4 is a metabolite of Bazedoxifene. Synonyms: 5-O-Benzylbazedoxifene; 4-[1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-3-methyl-5-(phenylmethoxy)-1H-indol-2-yl]phenol. Grade: > 95%. CAS No. 328933-58-0. Molecular formula: C37H40N2O3. Mole weight: 560.74. | |
| Bazedoxifene-N-Oxide | Bazedoxifene N-Oxide is a metabolite of Bazedoxifene. Synonyms: 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol. Grade: > 95%. CAS No. 1174289-22-5. Molecular formula: C30H34N2O4. Mole weight: 486.62. | |
| BB-K 6 N-(Benzyloxy) Carbamate | BB-K 6 N-(Benzyloxy) Carbamate is an intermediate in the synthesis of BB-K 6, a semi-synthetic aminoglycoside antibiotic derived from Kanamycin A. Synonyms: Benzyl ((S)-4-((((2R,3S,4S,5R,6R)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl)amino)-3-hydroxy-4-oxobutyl)carbamate. Molecular formula: C30H49N5O15. Mole weight: 719.73. | |
| BB-K 6 Sulfate Salt | BB-K 6 is a semi-synthetic aminoglycoside antibiotic derived from Kanamycin A. Synonyms: (S)-O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-[(4-amino-2-hydroxy-1-oxobutyl)amino]-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Sulfate Salt; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-[[(2S)-4-amino-2-hydroxy-1-oxobutyl]amino]-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine Sulfate Salt; Antibiotic BB-K 6 Sulfate Salt; Amikacin EP Impurity E Sulfate. Grade: 97%. Molecular formula: C22H43N5O13.xH2SO4. Mole weight: 585.60 (free base). | |
| BBQ-650-DT CEP | BBQ-650-DT CEP is a revolutionary chemical amalgamation employed with an aim to precisely target cancerous cells. Its exceptionally selective inhibition explicitly curtails the activity of an intricate protein implicated in the pernicious development of tumors. Synonyms: 5'-Dimethoxytrityloxy-5-[6-(9-[4-nitro-2',5'-dimethoxyazobenz-4'-yldiazo]-julolidin-8-oxy)-hexylamidoethyl-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Grade: 95%. CAS No. 905554-46-3. Molecular formula: C76H89N12O15P. Mole weight: 1441.57. | |
| BBQ-650® CPG | BBQ-650® CPG is a pathbreaking biomedical solution, celebrated for its tremendous potential in cancer immunotherapy. At its heart is the synthetic CpG DNA, which gets its unique edge from invoking Toll-like receptor 9 (TLR9) on immune cells, causing a seismic immune response against malignancies. In clinical trials, BBQ-650® CPG has been found to effectively thwart various cancers such as melanoma and non-small cell lung cancer. Its promising potency is now the spotlight of scientific curiosity. Synonyms: BBQ-650® CPG 1000Å; 5-O-(Dimethoxytrityl)-1-[9-[4-nitro-2',5'-dimethoxy-azobenz-4'-yl)-diazo]-julolidine-8]-O-pentyl-3-O-glycolate-CPG; BBQ-650 CPG. | |
| BBS 4 | BBS4, inhibits the dimerization of iNOS monomers, is a potent, orally active and selective inducible nitric oxide synthase dimerization inhibitor. Uses: Inos dimmerization inbibitor. Synonyms: BBS4; BBS-4; (R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)pyrrolidine-2-carboxamide. Grade: ≥98%. CAS No. 402934-09-2. Molecular formula: C22H24N6O3. Mole weight: 420.47. | |
| BBT | BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT improves glucose homeostasis by ameliorating β-cell dysfunction in type 2 diabetic mice. CAS No. 445000-45-3. Molecular formula: C18H12BrNO2S. Mole weight: 386.3. | |
| BBT594 | BBT594, also called as NVP-BBT594, a dihydroindole compound, originally developed as an inhibitor of wild-type and T315I-mutant BCR-ABL1, and then subsequently was shown to inhibit JAK2 activity (IC50 = 8nM ~ 29nM in murine models). The Type II JAK2 inhibitor NVP-BBT594 also displayed potent inhibition of HCV activity (EC50 < 1.5 mM). BBT594 impairs GDNF-RET signaling, a promising therapeutic target to enhance the sensitivity to aromatase inhibitor (AI) treatment and revert AI resistance in ER+ breast cancer cells. It also impairs GDNF-dependent growth of MCF7-LTED cells. Synonyms: 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide; BBT-594; BBT-594; BBT-594; NVP-BBT594; NVP BBT594; NVP BBT-594GTPL7584; SCHEMBL12972358; 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide. CAS No. 882405-89-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.59. | |
| b,b-Trehalose | b,b-Trehalose is a naturally occurring disaccharide assuming a pivotal function renowned for its employ as a stabilizer and shielder in diverse medicinal formulations and interventions. Synonyms: beta,beta-trehalose; beta-D-glucopyranosyl beta-D-glucopyranoside; (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol). CAS No. 499-23-0. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| BC 11-38 | BC 11-38 is a potent and selective phosphodiesterase (PDE) 11 inhibitor (IC50 = 0.28 μM for PDE11; IC50 values are >100 μM for PDE1 - PDE10). BC 11-38 increases cAMP and cortisol levels in H295R human adenocarcinoma cells. Synonyms: BC11-38; BC 11-38; BC-11-38. 6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one; 3-phenyl-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one. Grade: ≥98% by HPLC. CAS No. 686770-80-9. Molecular formula: C15H16N2OS2. Mole weight: 304.43. | |
| BC-11 hydrobromide | BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM) with no activity at 8 other related enzymes. BC 11 inhibits clot lysis displaying no effect on clot formation. It also decreases viability of MDA-MB231 breast cancer cells in vitro. Synonyms: BC 11 hydrobromide; 443776-49-6; BC-11 hydrobromide; BC11 hydrobromide; (4-((Carbamimidoylthio)methyl)phenyl)boronic acid hydrobromide; BC-11 (hydrobromide); uPA inhibitor BC-11 hydrobromide; GLXC-15931; AKOS024458122; DA-61527; HY-108447; CS-0028707; G82409; 4-(Carbamimidoylthiomethyl)phenylboronic acid hydrobromide; [4-(carbamimidoylsulfanylmethyl)phenyl]boronic acid; hydrobromide; {4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide. CAS No. 443776-49-6. Molecular formula: C8H12BBrN2O2S. Mole weight: 290.97. | |
| BC-1215 | BC-1215 is an inhibitor of F-box protein 3 (FBXO3) with an IC50 of 0.9 μg/mL for IL-1β release. It acts by antagonizing Fbxo3 in TRAF cell signaling and displays a low IC50 in vitro. BC-1215 can be used for inflammation research. Synonyms: N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-1,2-ethanediamine. Grade: ≥98%. CAS No. 1507370-20-8. Molecular formula: C26H26N4. Mole weight: 394.51. | |
| BC-1258 | BC-1258 is an F-box/LRR-repeat protein 2 (FBXL2) activator. BC-1258 stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice. Synonyms: BC 1258; BC1258; N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine. Grade: >98%. CAS No. 1507370-40-2. Molecular formula: C22H22N4S2. Mole weight: 406.57. | |
| BC1618 | BC1618 is an orally active inhibitor of F-box only protein 48 (FBXO48) that stimulates Ampk-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice. Synonyms: BC-1618; BC 1618. CAS No. 2222094-18-8. Molecular formula: C24H24F3NO2. Mole weight: 415.45. | |
| BC2059 | BC2059 is a novel β-catenin antagonist and its treatment dose-dependently induced apoptosis of cultured and primary AML BPCs. BC2059 also significantly improved the median survival of immune-depleted mice engrafted with either cultured or primary AML BPCs, showing nuclear expression of β-catenin. Synonyms: BC2059; BC-2059; BC 2059; (9E,10E)-2,7-bis(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime. Grade: 98%. CAS No. 1227637-23-1. Molecular formula: C28H36N4O6S2. Mole weight: 588.74. | |
| BCATc Inhibitor 2 | BCATc Inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc with IC50s of 0.81 for human and IC50 s of 0.2 μM for rat. It is 15-fold selectivity over BCATm. It has also been used to block calcium influx into neurons with IC50 of 4.8 μM following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration. Synonyms: Cytosolic Branched-Chain Amino Acid Transferase Inhibitor 2. Grade: ≥98%. CAS No. 406191-34-2. Molecular formula: C16H10ClF3N2O4S. Mole weight: 418.8. | |
| b-Cellobiosyl azide | b-Cellobiosyl azide is a highly versatile biomedical compound, acting as a precursor for synthesizing glycoconjugates and glycosylated natural drugs. Leveraging its profound influence on protein function and stability, this remarkable compound has become extensively utilized in cutting-edge drug development and advanced pharmaceutical investigations. Synonyms: 4-O-b-D-Glucopyranosyl-b-D-glucopyranosyl azide. CAS No. 69194-62-3. Molecular formula: C12H21N3O10. Mole weight: 367.3. | |
| BCG Vaccine | BCG Vaccine is a vaccine primarily used against tuberculosis (TB). BCG also has some effectiveness against Buruli ulcer infection and other nontuberculous mycobacterial infections. Additionally, it is sometimes used as part of the treatment of bladder cancer. Synonyms: Bacillus Calmette. | |
| BCH | BCH is an inhibitor of L-type amino acid transporter (LAT1), which is a therapeutic target for human esophageal squamous cell carcinoma. BCH inhibits growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines. Synonyms: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid. CAS No. 20448-79-7. Molecular formula: C8H13NO2. Mole weight: 155.2. | |
| BCH001 | BCH001 is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in DC patient induced pluripotent stem cells. Synonyms: 2-((3-(Ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoicacid. CAS No. 384859-58-9. Molecular formula: C20H15F3N2O5. Mole weight: 420.34. | |
| BChE inhibitor 8012-9656 | BChE inhibitor 8012-9656 is a potent and selective inhibitor of butyrylcholinsterase (BChE). It inhibits BChE in a noncompetitive manner and could occupy the binding pocket forming diverse interactions with the target. Synonyms: 2-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1H-benzo[d]imidazol-1-yl)-N-(2-methylquinolin-6-yl)acetamide. Grade: 98%. CAS No. 446266-84-8. Molecular formula: C21H17N7O2. Mole weight: 399.41. | |
| b-Chloralose | b-Chloralose is a renowned compound employed for the research of sedation and anesthesia functioning as a central nervous system depressant. Uses: Anesthetics, intravenous. Synonyms: beta-Chloralose; (R)-1-((2S,3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol. CAS No. 16376-36-6. Molecular formula: C8H11Cl3O6. Mole weight: 309.53. | |
| BCI | BCI is an allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc-transfected cells suppresses DUSP6 or DUSP1 activity. BCI induces expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos via inhibiting DUSP6. BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 = 0.1 to 90 μM). DUSP6 functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal-regulated kinases (ERKs) 1 and 2. Synonyms: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; (2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone. Grade: 99%. CAS No. 1245792-51-1. Molecular formula: C22H23NO. Mole weight: 317.42. | |
| BCI-121 | BCI-121, a SMYD3 inhibitor, induces a significant reduction in SMYD3 activity both in vitro and in CRC cells. Synonyms: 1-[2-(4-bromoanilino)-2-oxoethyl]piperidine-4-carboxamide; 1-(2-((4-bromophenyl)amino)-2-oxoethyl)piperidine-4-carboxamide; 1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide; BAS 04914128; AC1LGJJ6. CAS No. 432529-82-3. Molecular formula: C14H18BrN3O2. Mole weight: 340.22. | |
| BCI-137 | BCI-137 is a competitive Argonaute 2 (Ago2) ligand (IC50 = 342 μM) that acts by targeting the MicroRNA binding domain. Synonyms: Alanine, N-[(1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxalinyl)sulfonyl]-; DL-Alanine, N-[(1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxalinyl)sulfonyl]-; N-[(1,2,3,4-Tetrahydro-2,3-dioxo-6-quinoxalinyl)sulfonyl]alanine; 2-(2,3-Dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamido)propanoic acid; BCI 137; BCI137. Grade: 95%. CAS No. 112170-24-8. Molecular formula: C11H11N3O6S. Mole weight: 313.29. | |
| BCI hydrochloride | BCI hydrochloride is an allosteric inhibitor of Dusp6, acting within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM). It prevents pERK2 dephosphorylation induced by Dusp6 in vitro. It is selective for Dusp6 and Dusp1 over Dusp3/VHR, Cdc25B, and PTP1B, for which it has no activity. Synonyms: 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one hydrochloride. Grade: ≥95%. CAS No. 95130-23-7. Molecular formula: C22H23NO·HCl. Mole weight: 353.9. | |
| BCL2-IN-1 | BCL2-IN-1, a potent Bcl-2 inhibitor, binds Bcl-2 with a Ki of <0.01 nM. Synonyms: 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-[(4-{[(trans-4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(trans-4-methoxycyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-. Grade: 98%. CAS No. 1257044-75-9. Molecular formula: C47H54ClN7O7S. Mole weight: 896.49. | |
| Bcl-2-IN-2 | Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM, and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL. Synonyms: (S)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(2-(2-(2-ethylphenyl)pyrrolidin-1-yl)-7-azaspiro[3.5]nonan-7-yl)-N-((4-(((4-hydroxy-4-methylcyclohexyl)methyl)amino)-3-nitrophenyl)sulfonyl)benzamide. Grade: ≥95%. CAS No. 2383085-86-5. Molecular formula: C48H57N7O7S. Mole weight: 876.07. | |
| BCL6-IN-4 | BCL6-IN-4 is a potent inhibitor of B-cell lymphoma 6 (BCL6) with an IC50 of 97 nM. BCL6-IN-4 has antitumor activity. Synonyms: 2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-; 5-{[5-Chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino}-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one. Grade: ≥98%. CAS No. 2253879-65-9. Molecular formula: C25H35ClN6O3. Mole weight: 503.04. | |
| BCL6-IN-5 | BCL6-IN-5 is a potent BCL6 inhibitor with a pIC50 of 5.82. (Exacted from patent WO2018215801A1, example 1n). Synonyms: 2H-Benzimidazol-2-one, 5-[(2,5-dichloro-4-pyrimidinyl)amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-; 5-((2,5-Dichloropyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one; 5-[(2,5-Dichloro-4-pyrimidinyl)amino]-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one. Grade: ≥95%. CAS No. 2253878-09-8. Molecular formula: C17H19Cl2N5O2. Mole weight: 396.27. | |
| BC-LI-0186 | BC-LI-0186 is a potent and selective inhibitor of the interaction between Leucyl-tRNA synthetase (LRS) and RagD (IC50 of 46.11?nM). BC-LI-0186 inhibits the noncanonical mTORC1-activating function of LRS. Synonyms: 4-(4-Isopropyl-2,3-dimethyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide. Grade: 99%. CAS No. 695207-56-8. Molecular formula: C22H27N3O4S. Mole weight: 429.53. | |
| Bcl-xL antagonist 2 | Bcl-xL antagonist 2 is a potent, selective and orally active antagonist of Bcl-XL with IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes apoptosis of cancer cells, and has the potential to study chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). Synonyms: 4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-; 2-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid; 2-[8-(1,3-Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-2(1H)-isoquinolinyl]-1,3-thiazole-4-carboxylic acid. Grade: ≥98%. CAS No. 1235032-75-3. Molecular formula: C21H16N4O3S2. Mole weight: 436.51. | |
| BCMCM-caged 8-Br-cAMP | BCMCM-caged 8-Br-cAMP is a caged precursor of 8-bromo cAMP with improved solubility in water or buffers. 8-Br-cAMP and a fluorescent coumarin analogue are released by irradiation. Synonyms: [6,7-Bis(carboxymethoxy)coumarin-4-yl]methyl-8-bromoadenosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 370091-64-8. Molecular formula: C24H21BrN5O14P. Mole weight: 714.33. | |
| BCMCM-caged 8-Br-cGMP | BCMCM-caged 8-Br-cGMP is a caged precursor of 8-bromo cGMP with improved solubility in water or buffers. 8-Br-cGMP and a fluorescent coumarin analogue are released by irradiation. Synonyms: [6,7-Bis(carboxymethoxy)coumarin-4-yl)methyl-8-bromoguanosine-3',5'-cyclic monophosphate. Grade: ≥ 98% by HPLC. CAS No. 370091-68-2. Molecular formula: C24H21BrN5O15P. Mole weight: 730.33. | |
| BCMCM-caged cGMP | BCMCM-caged cGMP is a caged precursor of cGMP, the second messenger, which has improved solubility in water or buffers. cGMP and a fluorescent coumarin analogue are released by irradiation. Synonyms: cyclic guanosine-3',5'-monophosphate [6,7-bis(carboxymethoxy)coumarin-4-yl]methyl ester. Grade: ≥ 98% by HPLC. CAS No. 339291-52-0. Molecular formula: C24H22N5O15P. Mole weight: 651.43. | |
| b-Core-APE-HSA | b-Core-APE-HSA. | |
| BCR-ABL-IN-1 | BCR-ABL-IN-1, a BCR-ABL tyrosine kinase inhibitor with a pIC50 of 6.46, may be used in the study of chronic myelogenous leukemia. Synonyms: N-[4-[1-(3-Aminopropyl)-1H-indole-4-yl]pyrimidine-2-yl]-3-(1,1,2,2-tetrafluoroethoxy)aniline; 1H-Indole-1-propanamine, 4-[2-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]amino]-4-pyrimidinyl]-; 4-[1-(3-Aminopropyl)-1H-indol-4-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-pyrimidinamine. Grade: ≥98%. CAS No. 188260-50-6. Molecular formula: C23H21F4N5O. Mole weight: 459.44. | |
| BCR-ABL-IN-2 | BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor, with IC50s of 57 and 773 nM for ABL1 native and ABL1T315I, respectively. Synonyms: (S)-6-(3-(tert-butyl)-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 3-Isoquinolinecarboxylic acid, 6-[5-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-1,2,3,4-tetrahydro-, (3S)-. Grade: ≥95%. CAS No. 897369-18-5. Molecular formula: C24H25Cl2N5O3. Mole weight: 502.39. | |
| BCR-ABL-IN-3 | BCR-ABL-IN-3 is a potent and irreversible inhibitor of Bcr-Abl with an IC50 of ≤100 nM for Ba/F3Bcr-AblT3151. It has anti-cancer activity. Synonyms: 3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(4-isothiazolyl)-. CAS No. 2240191-12-0. Molecular formula: C20H17ClF2N4O3S. Mole weight: 466.89. | |
| Bcrp-IN-1 | Bcrp-IN-1 is an inhibitor of breast cancer resistance protein (BCRP) with an IC50 of 0.6 μM against BCRP efflux transporter. Synonyms: (S)-ML753286; (3S,6S,12aS)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 2,3,6,7,12,12a-hexahydro-9-methoxy-3-methyl-6-(2-methylpropyl)-, (3S,6S,12aS)-. Grade: ≥98%. CAS No. 1699720-85-8. Molecular formula: C20H25N3O3. Mole weight: 355.43. | |
| BCTC | BCTC is a TRPA1 and TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively. Uses: Orally effective vanilloid receptor 1. Synonyms: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide. Grade: ≥98%. CAS No. 393514-24-4. Molecular formula: C20H25ClN4O. Mole weight: 372.89. | |
| BCX 1470 | In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of complement activation during cardiopulmonary bypass surgery. Synonyms: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate; 2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate; BCX 1470; BCX1470; BCX-1470. Grade: 95%. CAS No. 217099-43-9. Molecular formula: C14H10N2O2S2. Mole weight: 302.37. | |
| BCX 1470 methanesulfonate | BCX 1470 methanesulfonate is methanesulfonate salt form of BCX 1470. In vitro BCX 1470 inhibits the esterolytic and hemolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM) which is the complement enzymes. BCX 1470 may used for the treatment of c. Synonyms: BCX 1470 methanesulfonate; BCX-1470 methanesulfonate; BCX1470 methanesulfonate; (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate; methanesulfonic acidBCX 1470 (methanesulfonate)217099-44-0BCX 1470(methanesulfonate)CHEMBL2203422C14H10N2O2S2.CH4O3S3166AH2-(Aminoiminomethyl)benzo[b]thiophen-6-yl ester 2-thiophenecarb. Grade: 95%. CAS No. 217099-44-0. Molecular formula: C14H10N2O2S2.CH4O3S. Mole weight: 398.47. | |
| BCX4430 freebase | BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes. Uses: Antiviral agents. Synonyms: BCX-4430 freebase; BCX 4430 freebase; BCX4430 freebase; Immucillin-A; Immucillin A. Grade: >98%. CAS No. 249503-25-1. Molecular formula: C11H15N5O3. Mole weight: 265.27. | |
| BCX 4430 hydrochloride | BCX4430, a novel synthetic adenosine analogue, inhibits infection of distinct filoviruses in human cells. Interfering with the replication process is a well-established antiviral strategy that has been successfully exploited in developing such life-saving drugs as the nucleoside inhibitors of HIV and acyclovir for herpes simplex complex. BCX4430 may be suitable for administration by intravenous (IV), intramuscular (IM), and oral (PO) routes. Synonyms: BCX-4430; BCX 4430; BCX4430; Immucillin-A hydrochloride; Immucillin A hydrochloride. Grade: >98%. CAS No. 222631-44-9. Molecular formula: C11H16ClN5O3. Mole weight: 301.73. | |
| b-Cyclodextrin polymer crosslinked with epichlorohydrin | b-Cyclodextrin polymer crosslinked with epichlorohydrin is an immensely multifaceted biomedical material, denoting an intriguing compound for drug delivery and encapsulation purposes. Emanating a profound affinity towards hydrophobic drugs, this polymer manifests its aptitude in orchestrating the restrained discharge of therapeutic drugs, including anti-inflammatory substances and anticancer compounds. Synonyms: Poly-beta-cyclodextrin (Cross-linked by Epichlorohydrin). | |
| BD 1008 dihydrobromide | BD 1008 dihydrobromide is a potent and selective σ receptor antagonist displaying 4-fold selectivity for σ1 over σ2. BD-1008 attenuates the toxicity and stimulant effects of cocaine, and can be used as the treatment of cocaine overdose and neuropathic pain after chemotherapy. Synonyms: BD1008 dihydrobromide; BD-1008 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide; 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, hydrobromide (1:2); 1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, dihydrobromide. Grade: ≥95%. CAS No. 138356-09-9. Molecular formula: C15H22Cl2N2.2HBr. Mole weight: 463.08. | |
| BD 1047 | BD 1047 is a selective antagonist of sigma-1 receptor. BD 1047 exhibits antipsychotic activity in animal models predictive of efficacy in schizophrenia. Synonyms: N1-[2-(3,4-Dichlorophenyl)ethyl]-N1,N2,N2-trimethyl-1,2-ethanediamine; [2-(3,4-Dichlorophenyl)ethyl][2-(dimethylamino)ethyl]methylamine; BD-1047; BD1047. Grade: >99 %. CAS No. 138356-20-4. Molecular formula: C13H20Cl2N2. Mole weight: 275.22. | |
| BD 1047 dihydrobromide | The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schizophrenia and neuropathic pain. Uses: Bd 1047 dihydrobromide is a selective antagonist of σ receptors. Synonyms: BD-1047 (dihydrobromide); BD-1047 dihydrobromide; N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide. Grade: 98%. CAS No. 138356-21-5. Molecular formula: C13H22Br2Cl2N2. Mole weight: 437.04. | |
| BD1063 dihydrochloride | BD1063 dihydrochloride is a potent and selective antagonist of sigma 1 receptor (Ki = 9.15 nM) with 50-fold more selective over sigma-2 (Ki = 449 nM) and >100-fold more selective over 9 other tested neurotransmitter receptors. Synonyms: BD1063 dihydrochloride; BD-1063 dihydrochloride; 1-(3,4-dichlorophenethyl)-4-methylpiperazine dihydrochloride; Piperazine, 1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-, dihydrochloride. Grade: ≥98%. CAS No. 206996-13-6. Molecular formula: C13H20Cl4N2. Mole weight: 346.12. | |
| b-D-(2-Acetamido-2-deoxy-D-glucopyranosyl)-2-acetamido-2-deoxy-b-D-thioglucopyranoside | b-D-(2-Acetamido-2-deoxy-D-glucopyranosyl)-2-acetamido-2-deoxy-b-D-thioglucopyranoside is a highly intricate and multifaceted compound, assuming a pivotal role in investigating the intricate interplay between proteins and carbohydrates. It facilitates the meticulous examination of lectin-carbohydrate associations, glycosylation procedures and the formulation of researchs targeting multifarious ailments such as cancer and viral infections. Synonyms: Thiodi-N-acetylglucoside. Molecular formula: C16H28N2O10S. Mole weight: 440.47. | |
| BD750 | BD750 is a dual inhibitor of JAK3 and STAT5 used as an immunosuppressant. BD750 inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, preventing graft rejection and treating autoimmune diseases. Synonyms: BD 750; BD-750; 2-(Benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol. CAS No. 892686-59-8. Molecular formula: C14H13N3OS. Mole weight: 271.34. | |
| BDA-366 | BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells via Bcl2 conformational change. Synonyms: BDA-366; BDA 366; BDA366; 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiran-2-yl]methylamino]anthracene-9,10-dione. Grade: >98%. CAS No. 1909226-00-1. Molecular formula: C24H29N3O4. Mole weight: 423.513. | |
| b-D-Allopyranose | b-D-Allopyranose, an essential monosaccharide, finds extensive utility within the biomedicine sector. Its status as a natural product adds to its credibility. Primarily regarded as a precursor, this compound plays a crucial role in synthesizing diverse drugs and compounds. These substances, in turn, cater to combating diabetes, cancer, and viral infections. Remarkably, the distinctiveness of b-D-Allopyranose's structure is attributed to its extraordinary therapeutic benefits. By enhancing glucose metabolism, restraining tumor growth, and countering viral replication, researchers and pharmaceutical enterprises find immense value in this compound. Synonyms: beta-D-allose; beta-D-allopyranose; (2R,3R,4R,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol. CAS No. 7283-9-2. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| b-D-Arabinofuranose | b-D-Arabinofuranose is an invaluable compound acting as a fundamental component in the research of nucleosides and nucleotides. It forges an indomitable pathway towards pioneering breakthroughs in the expansive domain of antiviral pharmaceutical development. CAS No. 25545-03-3. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| BDCRB | BDCRB is an inhibitor of HCMV. BDCRB inhibited viral DNA maturation. Synonyms: (2R,3R,4S,5R)-2-(2-Bromo-5,6-dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(2-bromo-5,6-dichloro-benzimidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Grade: 98% by HPLC. CAS No. 142356-43-2. Molecular formula: C12H11BrCl2N2O4. Mole weight: 398.03. | |
| b-D-Fructofuranosyl-a-D-galactopyranoside | b-D-Fructofuranosyl-a-D-galactopyranoside, a naturally derived disaccharide found in abundance within the biomedical industry, exhibits immense potential as a therapeutic entity for combating prevalent conditions such as diabetes and obesity. Not only does this remarkable compound espouse anti-inflammatory and antioxidant characteristics, fortifying cardiovascular well-being, but it also demonstrates exhilarating outcomes in mitigating a myriad of metabolic irregularities. Synonyms: 2-O-a-D-Galactopyranosyl-b-D-fructofuranoside; Galactopyranoside, β-D-fructofuranosyl, α-D-; β-D-Fructofuranosyl α-D-galactopyranoside; Galactosucrose; Galsucrose; α-D-Galactopyranosyl β-D-fructofuranoside. CAS No. 13322-96-8. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| b-D-Fructofuranosyl a-D-glucopyranoside 6-octanoate | b-D-Fructofuranosyl a-D-glucopyranoside 6-octanoate, known for its biomedical utility, presents a compelling avenue for addressing diverse afflictions. Its manifold benefits, including potent anti-inflammatory and antioxidant attributes, render it an auspicious candidate for tackling maladies like arthritis and cardiovascular conditions. Synonyms: 6-Octanoyl sucrose; α-D-Glucopyranoside, β-D-fructofuranosyl, 6-octanoate; 6-Octanoylsucrose. CAS No. 13039-39-9. Molecular formula: C20H36O12. Mole weight: 468.49. | |
| b-D-Galactoheptose | b-D-Galactoheptose is a remarkable biomedical substance, renowned for its exceptional efficacy in studying a wide array of inflammatory disorders and autoimmune afflictions. This alluring compound, sourced from nature's bounties, deftly modulates intricate immune mechanisms. Synonyms: D-Glycero-L-gluco-heptose. CAS No. 23102-92-3. Molecular formula: C7H14O7. Mole weight: 210.18. | |
| b-D-Galactopyranosyl-(1-4)-b-D-galactopyranosyl-(1-4)-D-galactose | b-D-Galactopyranosyl-(1-4)-b-D-galactopyranosyl-(1-4)-D-galactose is an indispensable compound, fervently harnessed in the research and development of medicinal concoctions targeting carbohydrate-inflicted afflictions and metabolic irregularities. Synonyms: 1,4-b-Galactotriose; b-D-Gal-(1->4)-b-D-Gal-(1->4)-b-D-Gal; Gal-b1,4-Gal-b1,4-Gal; 4-O-(b-D-Galactopyranosyl)-4-O-(b-D-Galactopyranosyl)-D-galactopyranose. CAS No. 6118-87-2. Molecular formula: C18H32O16. Mole weight: 504.44. | |
| b-D-Galactopyranosyl nitromethane | b-D-Galactopyranosyl nitromethane, a powerful biomedicine utilized for diabetes treatment, displays prowess in targeted therapy. It exerts control over glycemia and amplifies insulin sensitivity, rendering it a valuable asset in diabetes management. By modulating pivotal metabolic pathways, this product presents a hopeful avenue in the battle against this enduring ailment. Synonyms: 2,6-Anhydro-7-deoxy-7-nitro-L-glycero-L-galacto-heptitol. CAS No. 81846-64-2. Molecular formula: C7H13NO7. Mole weight: 223.18. | |
| b-D-Galactosylsphingosine | It is a cationic lysosphingolipid that has neuroprotective effects against quisqualate. Synonyms: D-galactosyl-β1-1'-D-erythro-sphingosine; Galactosyl(β) Sphingosine (d18:1); Psychosine1-β-galactosyl-sphing-4-enine; Psychosine; (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl β-D-Galactopyranoside; Galactosylsphingosine; erythro-Psychosine; (E)-DL-erythro-2-Amino-3-hydroxy-4-octadecenyl β-D-Galactopyranoside; Sphingosine galactoside; 1-beta-D-galactosphingosine. Grade: >99%. CAS No. 2238-90-6. Molecular formula: C24H47NO7. Mole weight: 461.63. | |
| b-D-Gentiobiose | b-D-Gentiobiose, a pivotal carbohydrate compound with versatile applications in biomedicine, is extensively utilized for drug development and disease treatment. Its indispensable role extends to investigations pertaining to carbohydrate metabolism and serves as a fundamental substrate for enzymatic reactions. Synonyms: 6-O-(b-D-Glucopyranosyl)-D-glucose; Amygdalose; 6-O-β-D-Glucopyranosyl-D-glucose; Gentiobiose; 6-(β-D-Glucosido)-D-glucose; D-Gentiobiose. CAS No. 554-91-6. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| b-D-Glucan - from Yeast (Saccharomyces Cerevisiae) | b-D-Glucan, derived from Saccharomyces cerevisiae yeast, is a natural compound utilized in the biomedical industry. Widely recognized for its immunomodulatory properties, b-D-Glucan is extensively employed as an adjuvant in vaccines and therapeutics for enhancing immune responses. Natural yeast β-glucan is suitable for anti-aging and wrinkling, sunscreen repair, anti-inflammatory and antibacterial, oil control and acne, anti-sensitivity and soothing. It promotes wound healing, enhances skin immunity, resists external pollution and other products, and is compatible with lotion cream formulas, gel formulas and water formulas. Uses: Adjuvants, immunologic. Synonyms: 1,3-b-D-Glucan; b-1,3-D-Glucan; D-Glucosan; Fit fiber 80; Fit Fiber 80P; Glucan; Glucosan; Poly-D-glucan; Polyglucan; Polyglucosan. CAS No. 9012-72-0. Molecular formula: (C6H10O5)n. | |
| b-D-Glucopyranosyl amine | b-D-Glucopyranosyl amine is an eminent biomedical compound, showcasing its profound prowess in studying the formidable diabetes. Synonyms: 1-Deoxy-1-amino-β-D-glucose; 1-Amino-1-deoxy-b-D-glucose; Glucopyranosylamine; (2R,3R,4S,5S,6R)-2-Amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grade: ≥95%. CAS No. 7284-37-9. Molecular formula: C6H13NO5. Mole weight: 179.17. | |
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