BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| b-D-Glucopyranosyl fluoride | b-D-Glucopyranosyl fluoride, a paramount compound with extensive applications in biomedicine, assumes a pivotal role in the advancement of innovative pharmaceuticals targeting diverse ailments such as diabetes, cancer, and microbial infections. Its extraordinary chemical attributes render it a flawless contender for facilitating enzymatic and chemical conversions, thereby facilitating the synthesis of therapeutically targeted compounds. Moreover, b-D-Glucopyranosyl fluoride presents itself as an invaluable instrument in comprehending glycosylation mechanisms and scrutinizing molecular interplays associated with cellular signaling pathways. Thus, its significance in unraveling biological phenomena and pharmaceutical pursuits cannot be overstated. Synonyms: b-D-Glucopyranosyl fluoride; 7617-95-0; (2S,3R,4S,5S,6R)-2-fluoro-6-(hydroxymethyl)oxane-3,4,5-triol; 2-deoxy-2-fluro-d-glucose; SCHEMBL4340862; ATMYEINZLWEOQU-VFUOTHLCSA-; AKOS006370932; InChI=1/C6H11FO5/c7-6-5(11)4(10)3(9)2(1-8)12-6/h2-6,8-11H,1H2/t2-,3-,4+,5-,6-/m1/s1. CAS No. 7617-95-0. Molecular formula: C6H11FO5. Mole weight: 182.15. |  |
| b-D-Glucopyranosyl nitromethane | b-D-Glucopyranosyl nitromethane, a compound extensively utilized in the biomedical sector, displays immense worth. Operating as a transitional compound, it aids in the production of glycosylated medicines, including antiviral and anti-inflammatory agents. Further, it assumes a momentous function in addressing specific ailments such as diabetes and cancer. The remarkable qualities of b-D-Glucopyranosyl nitromethane render it an indispensable element in biomedical exploration and advancement of pharmaceuticals. Synonyms: beta-D-glucopyranosyl nitromethane; (2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(nitromethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 81846-60-8. Molecular formula: C7H13NO7. Mole weight: 223.18. | |
| b-D-Glucose-1-phosphate disodium salt | b-D-Glucose-1-phosphate disodium salt, an indispensable compound within the biomedical sector, assumes a pivotal position as a substrate in multifarious enzymatic reactions, particularly those germane to carbohydrate metabolism. With its extensive employment in biomedicine, this entity facilitates comprehensive exploration into glycogen storage ailments and elucidates the intricacies governing glucose metabolism. Consequently, it emerges as an invaluable asset for diligent scientists embarking upon therapeutic endeavors for associated metabolic irregularities. CAS No. 83833-15-2. Molecular formula: C6H11Na2O9P. Mole weight: 304.10. | |
| b-D-Glucosyl C4-ceramide | b-D-Glucosyl C4-ceramide, a pivotal element extensively employed in the biomedical sector owing to its commendable therapeutic capacities, exhibits an imperative presence in combating numerous ailments, such as cancer and neurodegenerative disorders. Primarily acting as a regulator within cellular signaling cascades, it concomitantly stimulates cellular proliferation and differentiation whilst impeding aberrant processes. Synonyms: [R-[R*,S*-(E)]]-N-[1-[(b-D-Glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecenyl]butanamide; Butanamide, N-[1-[(β-D-glucopyranosyloxy)methyl]-2-hydroxy-3-heptadecenyl]-, [R-[R*,S*-(E)]]-. CAS No. 111956-45-7. Molecular formula: C28H53NO8. Mole weight: 531.72. | |
| b-D-Glucosyl hesperidin | b-D-Glucosyl hesperidin is a remarkable and innovative biomedicine that holds great potential in addressing the intricate challenges posed by cardiovascular diseases and diabetes. This extraordinary natural derivative, derived from hesperidin - an awe-inspiring flavonoid exclusively bestowed by enchanting citrus fruits, tantalizes the scientific community with its profound implications. It marvelously exhibits an enticing combination of profound anti-inflammatory prowess and awe-inspiring antioxidant attributes, effectively combating the insidious forces that undermine our cardiovascular system. Proffering resplendent hope, b-D-Glucosyl hesperidin is renowned for its unprecedented capacity in mitigating blood pressure anomalies while concurrently dethroning detrimental cholesterol levels, thereby orchestrating a symphony of immeasurable well-being within our precious hearts. Synonyms: 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, mono-α-D-glucopyranoside, (2S)-. CAS No. 134065-26-2. Molecular formula: C34H44O20. Mole weight: 772.70. | |
| BDH succinate salt | An impurity of Ritonavir. Ritonavir is a selective HIV protease inhibitor. Synonyms: (2S,3S,5S)-5-tert-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane succinate; A-88820 hemisuccinate. Grade: 99%. CAS No. 183388-64-9. Molecular formula: 2(C23H32N2O3)?C4H6O4. Mole weight: 887.11. | |
| b-D-Lactosyltrichloroacetimidate heptaacetate | b-D-Lactosyltrichloroacetimidate heptaacetate is a crucial compound widely used in the biomedical industry. It serves as a versatile reagent for carbohydrate chemistry. This product facilitates the synthesis of various biologically active compounds, polysaccharides, and glycoconjugates. Its applications include drug development, targeting diseases like cancer, neurodegenerative disorders, and infectious diseases. With its exceptional properties, b-D-Lactosyltrichloroacetimidate heptaacetate plays a significant role in advancing biomedical research and therapeutic interventions. Synonyms: 4-O-(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)-b-D-glucopyranose 2,3,6-triacetate 1-(2,2,2-trichloroethanimidate); β-D-Glucopyranose, 4-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-, 2,3,6-triacetate 1-(2,2,2-trichloroethanimidate); (2R,3R,4S,5R,6S)-2-(Acetoxymethyl)-6-(((2R,3R,4S,5R,6S)-4,5-diacetoxy-2-(acetoxymethyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate. CAS No. 1142022-76-1. Molecular formula: C28H36Cl3NO18. Mole weight: 780.94. | |
| b-D-Maltose octaacetate | b-D-Maltose octaacetate is a chemical compound widely used in the compound industry. It is primarily utilized as a precursor for various pharmaceutical drugs, particularly in the research of diabetes and cardiovascular diseases. This compound plays a crucial role in the research and development of therapeutic agents aimed at controlling blood sugar levels and improving heart health. Synonyms: Octa-O-acetyl-b-D-maltose; Octaacetyl maltose; β-D-Glucopyranose, 4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-, 1,2,3,6-tetraacetate; 4-O-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl)-β-D-glucopyranose tetraacetate; NSC 1351; Octa-O-acetyl-β-D-maltose; Octa-O-acetyl-β-maltose; Octaacetyl-β-maltose; β-D-Maltopyranose octaacetate; β-D-Maltose octaacetate; β-Maltose octaacetate; β-Maltose peracetate. Grade: ≥98%. CAS No. 22352-19-8. Molecular formula: C28H38O19. Mole weight: 678.59. | |
| b-D-Mannopyranosyl nitromethane | b-D-Mannopyranosyl nitromethane, a potent bioactive compound employed in biomedicine, unveils remarkable antitumor and antiviral properties, used for stuyding sundry malignant neoplasms and viral afflictions. Synonyms: 2,6-Anhydro-1-deoxy-1-nitro-D-glycero-D-galacto-heptitol. CAS No. 93302-92-2. Molecular formula: C7H13NO7. Mole weight: 223.61. | |
| BDNF (human) | Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF Gene. BDNF is a member of the neurotrophin growth factor family, which binds and activates TrkB and p75 neurotrophin receptors. It can enhances the survival, growth and differentiation of neurons. BDNF has been shown to play a role in neuroplasticity, which allows nerve cells in the brain to compensate for injury. Synonyms: BDNF. Grade: ≥96%. CAS No. 218441-99-7. Mole weight: 26984. | |
| BDP5290 | BDP5290, is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. It has shown to block cancer invasion. Synonyms: 4-Chloro-1-(Piperidin-4-Yl)-N-[3-(Pyridin-2-Yl)-1h-Pyrazol-4-Yl]-1h-Pyrazole-3-Carboxamide; BDP 5290; BDP-5290. Grade: 98%. CAS No. 1817698-21-7. Molecular formula: C17H18ClN7O. Mole weight: 371.82. | |
| b-D-Ribopyranosyl amine | b-D-Ribopyranosyl amine, a compelling compound extensively utilized in the biomedical sector, has attracted considerable attention due to its potential therapeutic applications in various diseases, notably diabetes and cancer. Scientific investigations have unraveled its remarkable capabilities in governing blood glucose levels and restraining malignant cell growth. Synonyms: β-D-Ribopyranosylamine; NSC 129242; (2R,3R,4R,5R)-2-aminotetrahydro-2H-pyran-3,4,5-triol; 1-Amino-1-deoxy-beta-D-ribo-pentopyranose. Grade: ≥95%. CAS No. 85280-61-1. Molecular formula: C5H11NO4. Mole weight: 149.15. | |
| b-D-Thiogalactose | b-D-Thiogalactose is an essential biomedical compound, exhibiting remarkable potential in research of galactosemia, a multifaceted metabolic anomaly predicated on the inability to metabolize galactose. Functioning as an efficacious inhibitor, this compound deftly curtails galactose levels within the corporeal domain, skillfully impeding its pernicious aggregation. CAS No. 49858-49-3. Molecular formula: C6H12O5S. Mole weight: 196.22. | |
| b-D-Thiogalactose sodium salt | b-D-Thiogalactose sodium salt, a chemical compound utilized in biomedical research to scrutinize specific enzymatic reactions of sugars and carbohydrates, is also a significant component in the synthesis of chemical probes which could deepen our comprehension of selected biological processes. Its prospective therapeutic applications not only pertain to tackling metabolic disorders, particularly that of diabetes, but also extend to certain types of cancer. Synonyms: β-D-Galactopyranose, 1-thio-, sodium salt (1:1); Sodium, (β-D-galactopyranosylthio)-; β-D-Galactopyranose, 1-thio-, monosodium salt; 1-Thio-β-D-galactose sodium salt. CAS No. 42891-22-5. Molecular formula: C6H11NaO5S. Mole weight: 218.21. | |
| b-D-Thioglucose sodium salt | b-D-Thioglucose sodium salt, a chemical compound ubiquitous in medical research, has been applied extensively in studies exploring the intricacies of glucose metabolism which are of paramount importance in the advancement of our knowledge about diabetes. Additionally, it has shown promising capabilities in drug development which focus on glucose transporters and has garnered significant excitement for its potential to revolutionize personalized medicine for metabolic disorders. Synonyms: 1-Thio-b-D-glucose, sodium salt; 1-b-D-Glucosylthiose Sodium Salt; Glucothiose Sodium Salt; β-D-Glucopyranose, 1-thio-, sodium salt (1:1); β-D-Glucopyranose, 1-thio-, monosodium salt; 1-Thio-β-D-glucopyranose sodium salt; 1-Thio-β-D-glucose sodium salt; Thioglucose sodium salt. CAS No. 10593-29-0. Molecular formula: C6H11NaO5S. Mole weight: 218.21. | |
| b-D-Thioglucose sodium salt hydrate | b-D-Thioglucose sodium salt hydrate, a biomedical compound, exerts significant influence in the realm of research. With its pivotal contribution to the comprehension of glucose metabolism and elucidation of diabetes pathogenesis, this compound emerges as an invaluable asset. Synonyms: 1-Thio-b-D-glucose sodium salt hydrate. CAS No. 255818-98-5. Molecular formula: C6H11NaO5S.H2O. Mole weight: 236.22. | |
| b-D-Xylopyranosyl azide | b-D-Xylopyranosyl azide, a remarkable biomedical product, stands as an indispensable tool in the intricate realm of carbohydrate chemistry. With its exceptional versatility and ready accessibility, this compound serves as a pivotal cornerstone for synthesizing a vast array of glycosides. Furthermore, its inherent potential transcends boundaries, empowering the creation of innovative drugs and targeted vaccines. Synonyms: beta-Xylopyranosyl azide; β-D-Xylopyranosyl azide. CAS No. 51368-20-8. Molecular formula: C5H9N3O4. Mole weight: 175.14. | |
| b-D-Xylopyranosyl nitromethane | b-D-Xylopyranosyl nitromethane, a biomedical product, finds wide application in the therapeutic management of diverse disorders. Exhibiting potential as a drug, it effectively combats microbial infections, cancer, and parasitic diseases. The distinctive chemical characteristics of b-D-Xylopyranosyl nitromethane demonstrate promising outcomes towards inhibiting tumor progression and curtailing pathogen proliferation. Synonyms: 2,6-anhydro-1-deoxy-1-nitro-3,4,5-tri-o-acetyl-d-gulitol. CAS No. 20204-84-6. Molecular formula: C6H11NO6. Mole weight: 193.15. | |
| BE-16627B | BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. Synonyms: BE 16627B; BE16627B; L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine; N-[1,3-Dihydroxy-2-({1-hydroxy-2-[2-hydroxy-2-(hydroxyimino)ethyl]-4-methylpentylidene}amino)propylidene]valine. Grade: >98%. CAS No. 137530-61-1. Molecular formula: C31H35Cl2F6N3O3. Mole weight: 375.42. | |
| Beauvericin A | Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated from B. bassiana that has diverse biological activities. It is active against M. tuberculosis (MIC = 25 μg/ml) and P. falciparum (IC50 = 12 μg/ml). Synonyms: Beauvericin A; 165467-50-5; (3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-6-[(2S)-butan-2-yl]-4,10,16-trimethyl-12,18-di(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone; (3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-6,12-bis(1-methylethyl)-18-[(1S)-1-methylpropyl]-3,9,15-tris(phenylmethyl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone; CHEMBL506228; AKOS040754812. Grade: >95% by HPLC. CAS No. 165467-50-5. Molecular formula: C46H59N3O9. Mole weight: 797.97. | |
| BEC | BEC, also known as S-(2-boronoethyl)-L-cysteine, is a slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4-0.6 μM from kinetic analyses. It significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM. BEC does not inhibit NO synthase, and effectively prevented ACh tolerance in aortic and mesenteric artery preparations. Synonyms: S-(2-boronoethyl)-L-cysteine. Grade: ≥98%. CAS No. 63107-40-4. Molecular formula: C5H12BNO4S. Mole weight: 193. | |
| Becatecarin | Becatecarin is a synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. Synonyms: NSC 655649; BMS 181176; BMY 27557; 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-. Grade: ≥95%. CAS No. 119673-08-4. Molecular formula: C33H34Cl2N4O7. Mole weight: 669.55. | |
| BEC HCl | BEC HCl is an Arginase II inhibitor(Ki=0.31μM).In vitro,BEC HCl enhances NO-dependent smooth muscle relaxation by binding to arginase as a transition state analogue.In vivo,BEC HCl enhances peribronchiolar and perivascular inflammation in mice. Synonyms: (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride. Grade: 98%. CAS No. 222638-67-7. Molecular formula: C5H13BClNO4S. Mole weight: 229.482. | |
| Beclabuvir | Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabuvir is a thumb site 1-NS5B polymerase ligand. Beclabuvir has been shown to equally inhibit de novo and primer dependent synthesis, 5-75 fold more potently than previously studied compounds, thus resulting the most effective thumb site 1 inhibitor of genotype 1 (GT-1) NS5B polymerase. Synonyms: (4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide hydrochloride; BMS791325; BMS-791325; BMS 791325. Grade: 99.87%. CAS No. 958002-33-0. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
| Beclamide | Beclamide is a chlorinated benzylpropanamide that possesses anticonvulsant activity, has been used for the treatment of tonic-clonic seizyres and has sedative properties. Uses: Anticonvulsan. Synonyms: N-Benzyl-3-chloropropionamide; N-benzyl-3-chloropropanamide. Grade: ≥98%. CAS No. 501-68-8. Molecular formula: C10H12ClNO. Mole weight: 197.66. | |
| Beclometasone Dipropionate EP Impurity F | Beclometasone Dipropionate EP Impurity F is an impurity of beclomethasone dipropionate which known for its role as a glucocorticoid receptor agonist and extensively employed for treating respiratory conditions including asthma and allergies. Synonyms: Beclometasone EP Impurity F; 6α-Bromo Beclomethasone Dipropionate; 6α-Bromo-9-chloro-11β-hydroxy-16β-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate. CAS No. 887130-69-0. Molecular formula: C28H36BrClO7. Mole weight: 599.94. | |
| Beclometasone Dipropionate EP Impurity U | Beclometasone Dipropionate EP Impurity U is an impurity of beclomethasone dipropionate which is known for its role as a glucocorticoid receptor agonist and extensively employed for treating respiratory conditions including asthma and allergies. Synonyms: Betamethasone 9,11-Epoxide 17-Propionate; 9,11β-Epoxy-21-hydroxy-16β-methyl-3,20-dioxo-9β-pregna-1,4-dien-17-yl propanoate. CAS No. 79578-39-5. Molecular formula: C25H32O6. Mole weight: 428.52. | |
| Beclomethasone | Beclomethasone is a glucocorticoid which is used in chronic asthma and allergic rhinitis. It acts as an antiallergic, antiasthmatic (inhalant) and topical anti-inflammatory. Uses: Anti-asthmatic agents. Synonyms: 9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione; (11β,16β)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Chloro-16β-methylprednisolone; Becolvent. Grade: > 95%. CAS No. 4419-39-0. Molecular formula: C22H29ClO5. Mole weight: 408.93. | |
| Beclomethasone Dipropionate | Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis. Synonyms: (11β,16β)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 17,21-dipropionate; 9α-Chloro-16β-methylprednisolone 17,21-dipropionate; Aerobec; Aldecin; Anceron; Andion; Beclacin; Beclate; Beclazone; Beclomet; Beclometasone 17,21-dipropionate; Beclometasone dipropionate; Beclomethasone 17,21-dipropionate; Beclomethasone 17α,21-dipropionate; Becloneb; Beclotide; Becloval; Beclovent; Beclovent Inhaler; Becodisks; Beconase; Becotide; Belchlorhinol; Belcoforte; Belcomet; Clenil; Entyderma; Inalone R; Korbutone; Nasobec; orBec; Propaderm; Propaderm Forte; QVAR; Sanasthmax; Sanasthmyl; Sanasthymyl; Sch 8020W; Topster; Vancenase; Vanceril; Ventolair; Viarex; Viarox. Grade: >98%. CAS No. 5534-9-8. Molecular formula: C28H37ClO7. Mole weight: 521.04. | |
| Beclomethasone Dipropionate Impurity A | Beclomethasone Dipropionate Impurity A is a metabolite of Beclomethasone Dipropionate. Synonyms: Pregna-1,4-diene-3,20-dione, 9-chloro-11,17-dihydroxy-16-methyl-21-(1-oxopropoxy)-, (11.beta.,16.beta.)-; 9-Chloro-11β,17-dihydroxy-16β-methyl-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; (11β,16β)-9-Chloro-11,17-dihydroxy-16-Methyl-21-(1-oxopropoxy)-pregn. Grade: > 95%. CAS No. 69224-79-9. Molecular formula: C25H33ClO6. Mole weight: 464.99. | |
| Beclomethasone Dipropionate Impurity B | Beclomethasone Dipropionate Impurity B is an impurity of beclomethasone dipropionate which known for its role as a glucocorticoid receptor agonist and extensively employed for treating respiratory conditions including asthma and allergies. Synonyms: Beclomethasone 21-acetate 17-propionate; (11β,16β)-21-(acetyloxy)-9-chloro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-Acetate 17-Propionate. Grade: > 95%. CAS No. 5534-8-7. Molecular formula: C27H35ClO7. Mole weight: 507.03. | |
| Beclomethasone Dipropionate Impurity D | Beclomethasone Dipropionate Impurity D is an impurity retrieved from Beclomethasone Dipropionate, an efficacious glucocorticoid receptor agonist serving as an invaluable therapeutic intervention for an assortment of inflammatory respiratory ailments, notably asthma, chronic obstructive pulmonary disease (COPD) and allergic rhinitis. Synonyms: 9-bromo Beclomethasone Dipropionate; (11β,16β)-9-BroMo-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione. Grade: > 95%. CAS No. 52092-14-5. Molecular formula: C28H37BrO7. Mole weight: 565.51. | |
| Beclomethasone Dipropionate Impurity E | Beclomethasone Dipropionate Impurity E is an analogue of Beclomethasone Dipropionate. Synonyms: 6α-Chlorobeclomethasone Dipropionate; (6α,11β,16β)-6,9-Dichloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione; (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-dichloro-11-Hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9. Grade: > 95%. CAS No. 887130-68-9. Molecular formula: C28H36Cl2O7. Mole weight: 555.50. | |
| Beclomethasone Dipropionate Impurity H | Beclomethasone Dipropionate Impurity H is an active metabolite of Beclomethasone Dipropionate. Synonyms: Beclomethasone-17-monopropionate; 9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propanoate; 9-Chloro-11,21-dihydroxy-16-methyl-17-propionyloxypregna-1,4-diene-3,20-dione; (11,16)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pre. Grade: > 95%. CAS No. 5534-18-9. Molecular formula: C25H33ClO6. Mole weight: 464.99. | |
| Beclomethasone Dipropionate Impurity I | Beclomethasone Dipropionate Impurity I is an analogue of Beclomethasone Dipropionate. Synonyms: (16β)-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione. Grade: > 95%. CAS No. 52092-12-3. Molecular formula: C28H36O6. Mole weight: 468.60. | |
| Beclomethasone Dipropionate Impurity J | Beclomethasone Dipropionate Impurity J is an analogue of Beclomethasone Dipropionate. Synonyms: (9β,11β,16β)-9,11-Epoxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Beclomethasone 9,11-Epoxide 17,21-Dipropionate. Grade: > 95%. CAS No. 66917-44-0. Molecular formula: C28H36O7. Mole weight: 484.59. | |
| Beclomethasone Dipropionate Impurity L | Beclomethasone Dipropionate Impurity L is an impurity of Beclomethasone Dipropionate. Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregn-4-ene-3,20-dione; 1,2-Dihydrobeclometasone Dipropopionate. Grade: > 95%. CAS No. 114371-33-4. Molecular formula: C28H39ClO7. Mole weight: 523.07. | |
| Beclomethasone Dipropionate Impurity N | Beclomethasone Dipropionate Impurity N is an impurity in Beclomethasone Dipropionate formulations, a drug facilitating the efficacious alleviation of respiratory ailments like asthma and allergic rhinitis with utmost proficiency. Synonyms: 2-Bromo Beclomethasone Dipropionate; (11β,16β)-2-BroMo-9-chloro-11-hydroxy-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione. Grade: > 95%. CAS No. 1204582-47-7. Molecular formula: C28H36BrClO7. Mole weight: 599.95. | |
| Beclomethasone Dipropionate Impurity V | Beclomethasone Dipropionate Impurity V is a betamethasone impurity, an antiinflammatory agent. Synonyms: Betamethasone 9,11-Epoxide 21-Propionate; (9β,11β,16β)-9,11-Epoxy-17-hydroxy-16-methyl-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione. Grade: > 95%. CAS No. 205105-83-5. Molecular formula: C25H32O6. Mole weight: 428.53. | |
| Beclomethasone Dipropionate Monohydrate | Beclomethasone Dipropionate Monohydrate is a corticosteroid used in the biomedical industry to study various respiratory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). It possesses anti-inflammatory and immunosuppressive properties. Synonyms: BECLOMETHASONE DIPROPIONATE MONOHYDRATE; UNII-4H7L9AI22I; 77011-63-3; 4H7L9AI22I; DTXSID00227831; Vancenase AQ; Beclometasone dipropionate (monohydrate); BECLOMETASONE DIPROPIONATE MONOHYDRATE; BECLOMETASONE DIPROPIONATE MONOHYDRATE (EP IMPURITY); BECLOMETASONE DIPROPIONATE MONOHYDRATE (EP MONOGRAPH); BECLOMETASONE DIPROPIONATE MONOHYDRATE [EP IMPURITY]; BECLOMETASONE DIPROPIONATE MONOHYDRATE [EP MONOGRAPH]; Beconase aq (TN); BECONASEAQ; SCHEMBL74650; DTXCID50150322; HY-13571B; CS-0031089; D11572; BECLOMETASONE DIPROPIONATE MONOHYDRATE [WHO-DD]; Q27259586; BECLOMETHASONE DIPROPIONATE MONOHYDRATE [ORANGE BOOK]; [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate; hydrate; Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, Hydrate (1:1), (11beta,16beta)-. Grade: > 95%. CAS No. 77011-63-3. Molecular formula: C28H39ClO8. Mole weight: 539.08. | |
| Beclotiamine | An impurity of Thiamine. Thiamine, also known as vitamin B1, is a water-soluble vitamin essential for cellular energy production, nerve function, and overall metabolic health. It plays a crucial role in carbohydrate metabolism by acting as a cofactor for enzymes involved in glycolysis and the Krebs cycle. Thiamine deficiency can lead to serious conditions such as beriberi (wet or dry), Wernicke-Korsakoff syndrome, and congestive heart failure. Synonyms: Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methyl-, chloride (1:1); 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methylthiazolium chloride; 5-β-Chlorethylthiamine; Thiamine EP Impurity C chloride. Grade: ≥95%. CAS No. 13471-78-8. Molecular formula: C12H16Cl2N4S. Mole weight: 319.25. | |
| Beclotiamine hydrochloride | An impurity of Thiamine which is one of the first compounds recognized as a vitamin. Synonyms: Thiamine Impurity C HCl; Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methyl-, chloride, hydrochloride (1:1:1); 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methylthiazolium chloride, hydrochloride; Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-chloroethyl)-4-methyl-, chloride, monohydrochloride; 5-Chloroethylthiamine chloride hydrochloride; 5-Chloroethylthiamine hydrochloride; Chloroethylthiamine hydrochloride; Chlorothiamine; Thiamine EP Impurity C chloride hydrochloride. Grade: >95%. CAS No. 7275-24-3. Molecular formula: C12H17Cl3N4S. Mole weight: 355.72. | |
| Bectumomab | Bectumomab is a monoclonal IgG2a antibody directed against CD22. Bectumomab has been used in the treatment of non-Hodgkin's lymphoma. Synonyms: IMMU-LL 2. Grade: 95%. CAS No. 158318-63-9. | |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Synonyms: Sirturo; TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910. Grade: 98%. CAS No. 843663-66-1. Molecular formula: C32H31BrN2O2. Mole weight: 555.5. | |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Synonyms: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. Grade: >98%. CAS No. 845533-86-0. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. | |
| Bederocin | Bederocinis a MetS(methionyl-tRNA synthetase) inhibitor with antibacterial activity against clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, and other clinically important gram-positive bacteria. But Bederocinis has little activity against gram-negative bacteria. Uses: Antibacterials. Synonyms: REP8839; REP-8839; REP 8839; 4(1H)-Quinolinone, 2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl)methyl) mino)propyl)amino)-. Grade: 98%. CAS No. 757942-43-1. Molecular formula: C20H21BrFN3OS. Mole weight: 450.37. | |
| Befetupitant | Befetupitant is a potent and selective NK1 receptor antagonist. Befetupitant is potentially useful in controlling chemotherapy-induced nausea and vomiting. Synonyms: Ro 67-5930; Ro67-5930; Ro675930; Ro-675930; 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-morpholino-4-(o-tolyl)pyridin-3-yl)propanamide. Grade: >98%. CAS No. 290296-68-3. Molecular formula: C14H24Cl2N4O2. Mole weight: 565.56. | |
| Befiradol hydrochloride | Befiradol hydrochloride is a highly selective 5-HT1A receptor full agonist with >1000-fold selectivity compared to other types of receptors. It has been investigated for the treatment of Parkinson's disease patients who exhibit L-DOPA-induced dyskinesia. Synonyms: NLX-112 hydrochloride; F 13640 hydrochloride. Grade: ≥98%. Molecular formula: C20H23Cl2F2N3O. Mole weight: 430.32. | |
| Befotertinib | Befotertinib is a third generation EGFR tyrosine kinase inhibitor that can be used in the study of EGFR T790M-positive non-small cell lung cancer (NSCLC). Synonyms: D-0316; N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-; N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)prop-2-enamide. Grade: ≥98%. CAS No. 1835667-63-4. Molecular formula: C29H32F3N7O2. Mole weight: 567.61. | |
| Befunolol | Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. It works as a β-adrenergic partial agonist in isolated organs. Synonyms: 1-[7-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]-ethanone; (±)-Befunolol; 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran. CAS No. 39552-01-7. Molecular formula: C16H21NO4. Mole weight: 291.34. | |
| Begacestat | Begacestat is a selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase. Begacestat inhibits Abeta production with low nanomolar potency in cellular and cell-free assays of γ-secretase function. In Sep 2010, Phase-I for Alzheimer's disease in USA was discontinued. Uses: Alzheimer's disease. Synonyms: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI-953; GSI953; GSI 953. Grade: 98%. CAS No. 769169-27-9. Molecular formula: C9H8ClF6NO3S2. Mole weight: 391.74. | |
| Begelomab | Begelomab is a murine monoclonal antibody against human dipeptidyl peptidase 4 (dipeptidylpeptidase IV/DPPIV/DPP4/CD26). Synonyms: SAND-26; SAND 26; SAND26. Grade: 95%. CAS No. 1403744-56-8. | |
| Belantamab | Belantamab is a humanized monoclonal antibody directed against the B-cell maturation antigen (BCMA). Belantamab can be used in the synthesis of Belantamab mafodotin, an ADC developed for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM). Synonyms: GSK2857914; GSK 2857914; GSK-2857914. CAS No. 2061894-48-0. | |
| Belatacept | Belatacept is a soluble fusion protein that acts as a T-cell costimulation blocker. Synonyms: BMS 224818; BMS-224818; BMS224818; LEA 29Y. Grade: 95%. CAS No. 706808-37-9. | |
| Belcesiran | Belcesiran is an alpha-1-antitrypsin synthesis reducer. Synonyms: Dcr-a1at; all-P-ambo-2'-O-methyl-P-thioadenylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'- deoxy-2'-fluorocytidylyl-. CAS No. 2375562-54-0. Molecular formula: C666H877F15N231O417P57S6. Mole weight: 21033.47. | |
| Belimumab | Belimumab is a human monoclonal antibody that inhibits B lymphocyte stimulator (BLyS). Specific binding of belimumab with the soluble BLyS prevents the interaction of BLys with its three receptors and indirectly decreases the B-cell survival and production of autoantibodies. Belimumab has been approved for the treatment of systemic lupus erythematosus. Synonyms: Benlysta; LymphoStat B. CAS No. 356547-88-1. | |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Synonyms: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
| Belizatinib | Belizatinib is inhibitor of both anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases (TRK). Belizatinib can bind to and inhibit both ALK and TRK kinases and this inhibition can lead to the disruption of ALK- and TRK-mediated signaling and impede tumor cell growth in ALK/TRK-overexpressing tumor cells. Phase I/II clinical trials for Lymphoma, Non-small cell lung cancer and Solid tumours is on-going. Uses: Lymphoma; non-small cell lung cancer; solid tumours. Synonyms: TSR011; TSR011; TSR 011; Belizatinib; 4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide. Grade: 98%. CAS No. 1357920-84-3. Molecular formula: C33H44FN5O3. Mole weight: 577.75. | |
| Belnacasan | Belnacasan is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan inhibits interlukin-1β biosynthesis. Synonyms: VX 765, VX765, VX-765, Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide. Grade: ≥98%. CAS No. 273404-37-8. Molecular formula: C24H33ClN4O6. Mole weight: 509. | |
| Beloranib | Beloranib is an experimental drug candidate for the treatment of obesity. It was discovered by CKD Pharmaceuticals and is currently being developed by Zafgen. Beloranib, an analog of the natural chemical compound fumagillin, is an inhibitor of the enzyme METAP2. It was originally designed as angiogenesis inhibitor for the treatment of cancer. Uses: Angiogenesis inhibitors. Synonyms: 2-Propenoic acid, 3-[4-[2-(dimethylamino)ethoxy]phenyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (2E)-; CDK-732; CDK 732; CDK732; O-[4-(2-Dimethylaminoethoxy)-trans-cinnamoyl]fumagillol; 2-Propenoic acid, 3-[4-[2-(dimethylamino)ethoxy]phenyl]-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (2E)-; ZGN 440. Grade: ≥95%. CAS No. 251111-30-5. Molecular formula: C29H41NO6. Mole weight: 499.64. | |
| Beloranib Hemioxalate | Beloranib Hemioxalate is the acidic form of beloranib , which is an analog of the natural chemical compound fumagillin and is an experimental injectable drug candidate for the treatment of obesity. Synonyms: CKD 732; (2E)-(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl Ester 3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-propenoic Acid Ethanedioate (2:1). Grade: > 95%. CAS No. 529511-79-3. Molecular formula: C30H42NO8. Mole weight: 544.67. | |
| Belotecan | Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I. Uses: Topoisomerase i inhibitors. Synonyms: Camtobell; CKD602; CKD 602; CKD-602; (4S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione. CAS No. 256411-32-2. Molecular formula: C25H27N3O4. Mole weight: 433.50. | |
| Belotecan hydrochloride | Belotecan hydrochloride is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-, hydrochloride (1:1), (4S)-; (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; CKD 602; Belotecan monohydrochloride; (4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride; 7-[2-(N-Isopropylamino)ethyl]-(20S)-camptothecin hydrochloride; Camtobell hydrochloride. Grade: ≥98% by HPLC. CAS No. 213819-48-8. Molecular formula: C25H27N3O4.HCl. Mole weight: 469.96. | |
| Beloxepin | Beloxepin is a dual norepinephrine reuptake inhibitor and serotonin receptor antagonist. Synonyms: ADL-6906; ADL 6906; ADL6906; ORG-4428; ORG4428; ORG 4428. Grade: 98% by HPLC. CAS No. 135928-30-2. Molecular formula: C19H21NO2. Mole weight: 295.4. | |
| Belumosudil mesylate | Belumosudil is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively). Synonyms: KD025 mesylate; SLx-2119 mesylate; 2-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-(propan-2-yl)acetamide methanesulfonate (1:1). CAS No. 2109704-99-4. Molecular formula: C27H28N6O5S. Mole weight: 548.62. | |
| Belvarafenib | Belvarafenib is a potent and selective pan-RAF kinase inhibitor with IC50 of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively. Synonyms: GDC5573; RG6185; HM95573. CAS No. 1446113-23-0. Molecular formula: C23H16ClFN6OS. Mole weight: 478.93. | |
| Belvarafenib TFA | Belvarafenib TFA is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor. Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA. Grade: ≥99%. Molecular formula: C25H17ClF4N6O3S. Mole weight: 592.95. | |
| Bemarituzumab | Bemarituzumab is a humanized monoclonal antibody that blocks FGFR2b. Bemarituzumab was approved for the treatment of tumors overexpressing FGFR2b. CAS No. 1952272-74-0. | |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | |
| Bemnifosbuvir | Bemnifosbuvir is the precursor drug form of the antiviral nucleoside analogue AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 μM, respectively). Synonyms: propan-2-yl N-[(P5'S,2'R)-2-amino-2'-deoxy-2'-fluoro-N6,2'-dimethyl-OP-phenyl-5'-adenylyl]-L-alaninate; AT-511; N-[[P(S),2'R]-2-amino-2'-deoxy-2'-fluoro-N,2'-dimethyl-P-phenyl-5'-adenylyl]-L-alanine, 1-methylethyl ester. Grade: 98%. CAS No. 1998705-64-8. Molecular formula: C24H33FN7O7P. Mole weight: 581.53. | |
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