BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Bailiximab | Basiliximab is a chimeric anti-interleukin-2 receptor monoclonal antibody. It specifically binds to and blocks the alpha chain of interleukin-2 receptors (IL-2R alpha), also known as CD25 antigen, on the surface of activated T-lymphocytes. Synonyms: CHI 621; Simulect. CAS No. 179045-86-4. |  |
| BAL-101553·2HCl | BAL-101553 is an orally available, highly water-soluble lysine prodrug of the synthetic small molecule BAL-27862 with potential antitumor activity. Upon administration of BAL101553 and conversion into the active form BAL-27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells. Synonyms: Lisavanbulin dihydrochloride; Lisavanbulin HCl; BAL-101553 dihydrochloride; BAL 101553 dihydrochloride; BAL101553 dihydrochloride. Grade: 98%. CAS No. 1387574-54-0. Molecular formula: C26H31Cl2N9O3. Mole weight: 588.49. | |
| BAL27862 | BAL27862 is a novel synthetic potent inhibitor of tubulin polymerization that induces cancer cell death. BAL27862 is a novel microtubule-destabilizing drug that is currently undergoing phase I clinical evaluation as the prodrug BAL101553. Synonyms: Avanbulin; BAL-27862; BAL 27862. Grade: 98%. CAS No. 798577-91-0. Molecular formula: C20H17N7O2. Mole weight: 387.40. | |
| BAL-30072 | BAL-30072 is a siderophore sulfactam and monocyclic β-lactam antibiotic with antimicrobial activity against multiresistant gram-negative bacilli. BAL30072 shows MIC90s of 4 and 8 μg/mL for MDR Acinetobacter spp. and MDR P. aeruginosa, respectively. Synonyms: Antibiotic BAL 30072; BAL30072; BAL 30072; 4-Thiazoleacetamide, 2-amino-α-[[(1,4-dihydro-1,5-dihydroxy-4-oxo-2-pyridinyl)methoxy]imino]-N-[(3S)-2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]-, (αZ)-; (2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydro-2-pyridinyl)methoxy]imino}-N-[(3S)-2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]acetamide. Grade: ≥95%. CAS No. 941285-15-0. Molecular formula: C16H18N6O10S2. Mole weight: 518.48. | |
| Balaglitazone | The Rs for the separations were 3.5 for balaglitazone enantiomers, 3.5 for pioglitazone enantiomers, and 3.7 for rosiglitazone. The squared correlation coefficients (r2) were found to be 0.999 for all three compounds. Balaglitazone treated groups shown significantly reduce of HbA1c (%), FSG (mmol/L), postprandial glucose as comparison to pioglitazone. Balaglitazone 10 mg and 20 mg show the similar magnitudes of the effects which comparable to the effects seen in the pioglitazone 45 mg group. The incidence of fluid retention and fat accumulation fewer than those observed with pioglitazone 45 mg. Sixty male dio induced obese rats were divided into five categories: vehicle, pioglitazone 10 mg/kg, pioglitazone 30 mg/kg, balaglitazone 5 mg/kg, balaglitazone 10 mg/kg. At day -7, 21 and 42 fasting serum samples were collected and whole body tissue composition was evaluated by MR scanning. Synonyms: DRF-2593; NN-2344; DRF2593; NN2344; DRF 2593; NN 2344. Grade: >98%. CAS No. 199113-98-9. Molecular formula: C20H17N3O4S. Mole weight: 395.43. | |
| Balapiravir | Balapiravir is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. It is the tri-isobutyrate ester prodrug of R1479 under clinical development to improve exposure of R1479 upon oral administration. It was discontinued for safety reasons in 28-36% of patients and the percentage of patients with serious adverse events was dose related. Synonyms: R1626; R-1626; R 1626; RO4588161; RO-4588161; RO 4588161; Balapiravir. Grade: >98%. CAS No. 690270-29-2. Molecular formula: C21H30N6O8. Mole weight: 494.5. | |
| Balapiravir hydrochloride | Balapiravir hydrochloride is an orally active prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp). It is an NS5B inhibitor that has the potential to treat HCV infection. Synonyms: Ro 4588161 hydrochloride; R1626 hydrochloride; (2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-azido-2-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate) hydrochloride; 4'-C-azido-2',3',5'-tris(2-methylpropanoate)cytidine monohydrochloride; 4-Amino-1-(4-C-azido-2',3',5'-tri-O-(2-methylpropanoyl)-β-D-ribofuranosyl)pyrimidin-2(1H)-one monohydrochloride. Grade: ≥98% (HPLC). CAS No. 690270-65-6. Molecular formula: C21H31ClN6O8. Mole weight: 530.96. | |
| Balicatib | The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups O, L, M, H, respectively). Approximately 1 month after treatment initiation, the 50 mg/kg dose was decreased to 30 mg/kg. Twenty animals underwent sham-ovariectomies (group S). Bone mass was measured at 3-6 month intervals. At 18 months, vertebra and femur were collected for histomorphometry. Synonyms: AAE581; AAE-581; AAE 581. Grade: 0.98. CAS No. 354813-19-7. Molecular formula: C23H33N5O2. Mole weight: 411.54. | |
| Balofloxacin | Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase. Uses: Anti-bacterial agents. Synonyms: Balofloxacin; Balofloxacin [INN]; Q 35; UNII-Q022B63JPM; Q-35; Q35. Grade: >98%. CAS No. 127294-70-6. Molecular formula: C20H24FN3O4. Mole weight: 389.42. | |
| Balsalazide | Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is a new 5-aminosalicylic acid (5-ASA) containing prodrug. It is approved for the treatment of mild-to-moderate active UC. It is also efficacious for the induction of remission in mild to moderate UC and has a favorable safety profile. Synonyms: Colazal; Giazo. Grade: >98%. CAS No. 80573-04-2. Molecular formula: C17H15N3O6. Mole weight: 357.32. | |
| Balsalazide USP Impurity 1 | Balsalazide USP Impurity 1 is an impurity in the manufacturing process of Balsalazide, a medication used in the therapy of ulcerative colitis. Synonyms: 3-[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl] Balsalazide; (E,E)-3,5-Di-[4-(2-CarboxyethylcarbaMoyl)phenylazo]]salicylic Acid; 3,5-Bis[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoic Acid. Grade: > 95%. CAS No. 1242567-11-8. Molecular formula: C27H24N6O9. Mole weight: 576.53. | |
| Balsalazide USP Impurity 2 | Balsalazide USP Impurity 2 is an isomeric impurity of the anti-inflammatory drug Balsalazide. Synonyms: Balsalazide 3-Isomer; 3-[(1E)-2-[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoic Acid; (E)-3-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid. Grade: > 95%. CAS No. 1242567-09-4. Molecular formula: C17H15N3O6. Mole weight: 357.33. | |
| Balsalazide USP Impurity 3 | Balsalazide USP Impurity 3 is an impurity of the anti-inflammatory drug Balsalazide. Synonyms: 2'-[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl] Balsalazide; (E,E)-5-[[2-[4-(2-Carboxyethyl; 5-[(1E)-2-[2-[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl]-4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoic Acid. Grade: > 95%. CAS No. 1346606-53-8. Molecular formula: C27H24N6O9. Mole weight: 576.53. | |
| Balsalazide USP Impurity 4 | Balsalazide USP Impurity 4 is an impurity of the anti-inflammatory drug Balsalazide. Synonyms: 2-O-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl] Balsalazide; (E)-2-[4-(2-CarboxyethylcarbaMoyl)phenoxy]-5-[[4-(2-carboxyethylcarbaMoyl); 5-[(1E)-2-[4-[[(2-carboxyethyl)aMino]carbonyl]phenyl]diazenyl]-2-[[(2-carboxyethyl)aMino]carbonyl]phenoxy]benzoic Acid. Grade: > 95%. CAS No. 1346606-62-9. Molecular formula: C27H24N4O9. Mole weight: 548.51. | |
| Balsalazide USP Impurity 5 | Balsalazide USP Impurity 5 is an impurity of the anti-inflammatory drug Balsalazide. Synonyms: Balsalazide Isopropyl Ester; (E)-2-Hydroxy-5-[[4-[[(3-isopropoxy-3-oxopropyl)aMino]carbonyl]phenyl]azo]benzoic Acid; 5-[(1E)-2-[4-[[(1-Methylethoxy-3-oxopropyl)aMino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoic Acid. Grade: > 95%. CAS No. 1346606-13-0. Molecular formula: C20H21N3O6. Mole weight: 399.41. | |
| BAM 15 | BAM 15 is a novel mitochondrial protonophore uncoupler that uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). BAM 15 cannot depolarize the plasma membrane, and protects mice from acute renal ischemic-reperfusion injury. BAM 15 has the potential to treat obesity, Parkinson's disease, and aging. Synonyms: BAM15; BAM-15; N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine; N-[6-(2-Fluoroanilino)[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]-N-(2-fluorophenyl)amine. Grade: ≥98% by HPLC. CAS No. 210302-17-3. Molecular formula: C16H10F2N6O. Mole weight: 340.29. | |
| BAM7 | BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM. Synonyms: BAM 7; BAM-7; BAM7. Grade: >98%. CAS No. 331244-89-4. Molecular formula: C21H19N5O2S. Mole weight: 405.47. | |
| BAM (8-22) acetate | BAM (8-22) is an endogenous peptide agonist for the sensory neuron specific receptor (SNSR) (EC50 = 28 and 14 nM for SNSR3 and SNSR4, respectively). It exhibits spinal analgesic effects by interacting with NMDA receptors. BAM (8-22) displays no affinity for opioid receptors compared to BAM 22. Synonyms: Bovine Adrenal Medulla Peptide (8-22) acetate. Molecular formula: C93H131N25O25S. Mole weight: 2031.25. | |
| Bamaluzole | Bamaluzole is an agonist of GABA receptor. (Extracted from patent WO 2012064642 A1). Synonyms: 4-(2-chlorobenzyloxy)-1-methyl-1H-imidazo[4,5-c]pyridine; 4-o-Chlorobenzyloxy-1-methyl-1H-imidazo(4,5-c)pyridine; 1H-Imidazo(4,5-c)pyridine, 4-((2-chlorophenyl)methoxy)-1-methyl-. Grade: ≥95%. CAS No. 87034-87-5. Molecular formula: C14H12ClN3O. Mole weight: 273.72. | |
| Bamaquimast | Bamaquimast is an orally active inhibitor of proton pump with anti-inflammatory and antiasthmatic effects. Synonyms: Bamaquimast; F 10126; F-10126; F10126; L 0042; L-0042; L0042. 3-(3-oxo-4-propylquinoxalin-2-yl)propyl N-methylcarbamate. CAS No. 135779-82-7. Molecular formula: C16H21N3O3. Mole weight: 303.36. | |
| BAMB-4 | BAMB-4 is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It exhibits the lowest inhibition frequency among the InsP3-Kinase inhibitors. It is a promising therapeutic approach in lung cancer therapy. Synonyms: Bamb-4; Bamb 4; Bamb4; ITPKA-IN-C14. Grade: >98%. CAS No. 891025-25-5. Molecular formula: C15H12N2O2. Mole weight: 252.27. | |
| Bambuterol | Bambuterol is a long acting beta-adrenoceptor agonist (LABA) and is used in the treatment of asthma. It is an ester prodrug of the ß2-adrenergic agonist terbutaline. lt is contraindicated in pregnancy and in people with seriously impaired liver function. It can be used by people with renal impairment. It can prolong the time of parent drug action. It has a strong role in bronchial dilation and used for obstructive airway diseases, such as bronchial asthma, chronic bronchitis, tremor and cardiac side effects. It has the adverse effects, including fatigue, nausea, palpitations, headache, dizziness and tremor. lt was developed by the Astra company and has been listed in 1987. Uses: Bambuterol is used in the treatment of asthma. it can prolong the time of parent drug action. it has a strong role in bronchial dilation and used for obstructive airway diseases, such as bronchial asthma, chronic bronchitis, tremor and cardiac side effects. Synonyms: [3-(Dimethylcarbamoyloxy)-5-[1-hydroxy-2-(tert-butylamino)ethyl]phenyl]N,N-dimethylcarbamate; 5-[2-(ter-Butylamino)-1-hydroxyethyl]-1,3-phenylene bis(dimethylcarbamate); Bis(dimethylcarbamic acid)5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester; [3-[2-(tert-butylamino)-1-hydroxy-ethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate; N,N-dimethylcarbamic acid [3-[2-(tert-b. Grade: >98%. CAS No. 81732-65-2. Molecular formula: C18H29N3O5. Mole weight: 367.44. | |
| Bambuterol HCl | Bambuterol is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma. Synonyms: Bambuterol Hydrochloride; UNII-Y1850G1OVC; Bambuterol HCl; CHEBI:59167; DSSTox_CID_25515. Grade: >98%. CAS No. 81732-46-9. Molecular formula: C18H30ClN3O5. Mole weight: 403.9. | |
| Bamifylline | Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist. Synonyms: 7-[2-[Ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-1H-purine-2,6-dione; 8102 CB; Bax-2739Z; CB-8102; 8'-Benzyl-7-(2-[ethyl(2-hydroxyethyl)amino]ethyl)theophylline; Bamiphylline; Benzetamophylline. Grade: > 95%. CAS No. 2016-63-9. Molecular formula: C20H27N5O3. Mole weight: 385.47. | |
| Bamirastine | Bamirastine inhibits the binding of the ligand to the recombinant human histamine H1 receptor (rhH1R) with an IC50 of 17.3 nM. Synonyms: TAK-427; Bamirastina; 2-(6-((3-(4-(Diphenylmethoxy)piperidin-1-yl)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropanoic acid; Imidazo[1,2-b]pyridazine-2-acetic acid, 6-[[3-[4-(diphenylmethoxy)-1-piperidinyl]propyl]amino]-α,α-dimethyl-. Grade: 95%. CAS No. 215529-47-8. Molecular formula: C31H37N5O3. Mole weight: 527.66. | |
| Bamlanivimab | Bamlanivimab is a monoclonal antibody granted Emergency Use Authorization (EUA) in November 2020 by FDA for COVID-19 therapy. Bamlanivimab is directed against the spike protein of SARS-CoV-2, designed to block the virus' attachment and entry into human cells. Synonyms: Anti-Human SARS-CoV-2. CAS No. 2423943-37-5. Molecular formula: C22H28Cl2F3N3OS. Mole weight: 510.4. | |
| Bamocaftor | Bamocaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore the function of F508del-CFtr protein, can be used in combination with Tezacaftor and Ivacaftor in cystic fibrosis studies. Synonyms: VX-659; (S)-N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide; 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-; N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide. Grade: ≥95%. CAS No. 2204245-48-5. Molecular formula: C28H32F3N5O4S. Mole weight: 591.64. | |
| Bananin | Bananin is an effective adamantane-related molecule with antiviral activity, which has the potential for SARS-CoV research. Synonyms: bananin|CHEMBL4749450|SCHEMBL15466441|AKOS016036756|HY-145113|CS-0356439. Grade: >98%. CAS No. 665026-57-3. Molecular formula: C14H17NO8. Mole weight: 327.29. | |
| Banksialactone A | Banksialactone A is a fungal metabolite originally isolated from A. banksianus. Synonyms: Banksialactone A; 1135775-06-2; 3,4-dihydro-3,8-dihydroxy-3-(hydroxymethyl)-6-methoxy-4,5-dimethyl-1H-2-benzopyran-1-one; Compound NP-009116; ACon1_000304; HY-N8552; AKOS040739253; NCGC00180692-01; CS-0146519; BRD-A07411977-001-01-6; 3,8-dihydroxy-3-(hydroxymethyl)-6-methoxy-4,5-dimethyl-3,4-dihydro-1H-2-benzopyran-1-one. Grade: >95%. CAS No. 1135775-06-2. Molecular formula: C13H16O6. Mole weight: 268.26. | |
| BAN ORL 24 | BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM. Synonyms: Banyu Compound-24; CHEMBL201945; (R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)-1-benzylpyrrolidine-2-carboxamide; C-24. CAS No. 475150-69-7. Molecular formula: C27H35N3O2. Mole weight: 433.594. | |
| BAN ORL 24 dihydrochloride | BAN ORL 24 dihydrochloride is a hydrochloride salt form of BAN ORL 24. BAN ORL 24, a spiro-isobenzofuran compound, has been found to be a NOP receptor antagonist and could be used to restrain the reduction of locomotor motions with brain permeability. IC50: 0.27 nM. Synonyms: BAN ORL 24 diHCl; BAN ORL 24 HCl; (2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide dihydrochloride. CAS No. 1401463-54-4. Molecular formula: C27H37Cl2N3O2. Mole weight: 506.512. | |
| Banoxantrone | Banoxantrone is a bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. Synonyms: AQ-4N; AZD-1689; AQ4N; AZD1689; AQ 4N; AZD 1689. CAS No. 136470-65-0. Molecular formula: C22H28N4O6. Mole weight: 444.48. | |
| Banoxantrone dihydrochloride | Banoxantrone dihydrochloride, a bioreductive prodrug, can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor, and exhibits little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Uses: Antineoplastic agents. Synonyms: 2-[[4-[2-[dimethyl(oxido)azaniumyl]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]-N,N-dimethylethanamine oxide; dihydrochloride; UNII-658876KMFP; Banoxantrone (dihydrochloride). CAS No. 252979-56-9. Molecular formula: C22H30Cl2N4O6. Mole weight: 517.4. | |
| b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.Not a general deubiquitinase inhibitor. Has minimal inhibition on recombinant and cytosolic nonproteasomal cysteine deubiquitinases. Synonyms: b-AP15; b-AP15; b-AP-15; USP14 Inhibitor III; UCHL5UCH37 Inhibitor II; NSC687852. Grade: >98%. CAS No. 1009817-63-3. Molecular formula: C22H17N3O6. Mole weight: 419.39. | |
| Bapineuzumab | Bapineuzumab is a humanized monoclonal antibody that targets the N-terminal region of Aβ. Bapineuzumab has been investigated in Alzheimer's disease therapy. CAS No. 648895-38-9. | |
| BAR-501 | BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction. Synonyms: 3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501. CAS No. 1632118-69-4. Molecular formula: C26H46O3. Mole weight: 406.651. | |
| BAR502 | BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively). Synonyms: BAR-502; BAR 502; BAR502; (5S,8S,9R,10S,13R,14S,17R)-6-ethyl-17-(4-hydroxybutan-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol. CAS No. 1612191-86-2. Molecular formula: C25H44O3. Mole weight: 392.62. | |
| Barasertib | Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Synonyms: AZD1152; AZD-1152; AZD 1152; Barasertib. CAS No. 722543-31-9. Molecular formula: C26H31FN7O6P. Mole weight: 587.54. | |
| Barbadin | Barbadin is a selective β-arrestin/β2-adaptin interaction inhibitor. It blocks agonist-promoted endocytosis of the prototypical β2-adrenergic (β2AR), V2-vasopressin (V2R) and angiotensin-II type-1 (AT1R) receptors, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization. Synonyms: 3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one. Grade: 99%. CAS No. 356568-70-2. Molecular formula: C19H15N3OS. Mole weight: 333.41. | |
| Barbituric Acid-13C,15N2 | Parent compound of barbiturate drugs. Synonyms: 2,4,6(1H,3H,5H)-Pyrimidinetrione-13C,15N2; 1,2,3,4,5,6-Hexahydro-2,4,6-pyrimidinetrione-13C,15N2; 2,4,6-Pyrimidinetriol-13C,15N2; 2,4,6-Pyrimidinetrione-13C,15N2; 2,4,6-Trihydroxypyrimidine-13C,15N2; 2,4,6-Trioxohexahydropyrimidine-13C,15N2; 6-Hydroxyuracil-13C,15N2; Hexahydropyrimidine-2,4,6-trione-13C,15N2; Malonylurea-13C,15N2; NSC 7889-13C,15N2. CAS No. 1329809-18-8. Molecular formula: C3[13C]H4[15N]2O3. Mole weight: 131.07. | |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Synonyms: CDDO; RTA 401; RTA401; RTA-401. Grade: >98%. CAS No. 218600-44-3. Molecular formula: C31H41NO4. Mole weight: 491.66. | |
| Baricitinib | Baricitinib is a selective and orally bioactive inhibitor of JAK1 and JAK2. It has been approved by FDA for the treatment of rheumatoid arthritis (RA). Uses: The treatment of rheumatoid arthritis (ra). Synonyms: LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant. Grade: >98%. CAS No. 1187594-09-7. Molecular formula: C16H17N7O2S. Mole weight: 371.419. | |
| Baricitinib phosphate | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Synonyms: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. Grade: >98%. CAS No. 1187595-84-1. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. | |
| Barnetil | Barnetil acts as a selective D2 and D3 receptor antagonist, which has high affinity for these receptors of dissociation constants of 2.2 nM and 2.4 nM respectively. It is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. It has also been shown to have clinically relevant affinity for the GHB receptor. It was launched by Sanofi-Aventis in 1976. Synonyms: Benzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-; N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; (±)-Sultopride; Barnetil; LIN 1418. Grade: 98%. CAS No. 53583-79-2. Molecular formula: C17H26N2O4S. Mole weight: 354.46. | |
| Barnidipine | Barnidipine is a calcium channel blocker. Synonyms: (+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3S)-1-benzylpyrrolidin-3β-yl] ester; (S)-3-((S)-1-Be. Grade: > 95%. CAS No. 104713-75-9. Molecular formula: C27H29N3O6. Mole weight: 491.55. | |
| Barnidipine-d4 | Barnidipine-d4 is a labelled Barnidipine. Barnidipine is a calcium channel inhibitor used as an antihypertensive drug. Grade: > 95%. CAS No. 117152-15-5. Molecular formula: C27H25N3O6D4. Mole weight: 495.57. | |
| Barnidipine HCl | Barnidipine HCl is 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. It is a potential candidate in the treatment of patients with renal parenchymal hypertension. Uses: Calcium channel blockers. Synonyms: Mepirodipinehydrochloride; (+)-(3's,4s)-1-benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; (4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-[(3S)-1-(phenylmethyl)-3-py. Grade: > 95%. CAS No. 104757-53-1. Molecular formula: C27H30N3O6Cl. Mole weight: 528.01. | |
| barusiban | Barusiban is an oxytocin receptor antagonist with Ki of 0.8 nM. Synonyms: C(sup 4.6),S(sup 1)-Cyclo(N-(3-sulfanylpropanoyl)-D-tryptophyl-L-isoleucyl-L-alloisoleucyl-L-asparaginyl-L-2-aminobutanoyl-N-methyl-L-ornithinol). Grade: 95%. CAS No. 285571-64-4. Molecular formula: C40H63N9O8S. Mole weight: 830.05. | |
| Basmisanil | Basmisanil is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impairment associated with Down syndrome. In Apr 2016, Roche completed the phase II in Down syndrome (In adolescents, In adults) in USA, Argentina, Canada, France, Italy, Mexico, New Zealand, Singapore, Spain and the UK. In Sep 2016, Phase-II clinical trials in Neurological disorders (In adults, In the elderly) in Spain was on going. Uses: Down syndrome; neurological disorders. Synonyms: (1,1-dioxidothiomorpholino)(6-((3-(4-fluorophenyl)-5-methylisoxazol-4-yl)methoxy)pyridin-3-yl)methanone; RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582. Grade: 98%. CAS No. 1159600-41-5. Molecular formula: C21H20FN3O5S. Mole weight: 445.47. | |
| Batabulin sodium | Batabulin sodium is a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton. Synonyms: T138067 sodium; T138067-sodium; T 138067 sodium; T 67; D03059; D 03059; D-03059; T-138067 sodium. CAS No. 195533-53-0. Molecular formula: C13H7F6NO3S. Mole weight: 371.253. | |
| Batefenterol | Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. In Jul 2016, GlaxoSmithKline completed a phase II trial for Chronic obstructive pulmonary disease in USA, Germany and South Africa. Uses: Chronic obstructive pulmonary disease. Synonyms: GSK-961081; TD-5959; GSK 961081; TD 5959; GSK961081; TD5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate. Grade: 98%. CAS No. 743461-65-6. Molecular formula: C40H42ClN5O7. Mole weight: 740.25. | |
| Batefenterol edisylate | Batefenterol edisylate is the salt of Batefenterol, which is a β2 adrenergic receptor agonist and a muscarinic receptor antagonist. Synonyms: (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate ethane-1,2-disulfonic acid; 1,2-Ethanedisulfonic acid, compd. with 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]piperidinyl N-[1,1'-biphenyl]-2-ylcarbamate (1:x); Carbamic acid, [1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester, 1,2-ethanedisulfonate (salt). CAS No. 876126-19-1. Molecular formula: C40H42ClN5O7.xC2H6O6S2. Mole weight: 740.25 (free base). | |
| Batefenterol Succinate | Batefenterol is a beta 2 adrenergic receptor agonist and also a muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). Batefenterol is a hβ2-adrenoceptor agonist with EC50 value of 0.29 nM for stimulation of cAMP levels. This is 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors. Synonyms: Batefenterol Succinate; 945905-37-3; UNII-552KVF22JT; Batefenterol succinate [USAN]552KVF22JT. CAS No. 945905-37-3. Molecular formula: C44H48ClN5O11. Mole weight: 858.3. | |
| Batimastat | Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Batimastat acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Uses: Antineoplastic agents. Synonyms: (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide; BB94; BB-94; BB 94. Grade: 98%. CAS No. 130370-60-4. Molecular formula: C23H31N3O4S2. Mole weight: 477.638. | |
| Batimastat sodium salt | Batimastat sodium salt (BB-94) is a potent, broad spectrum matrix metalloprotease (MMPs) inhibitor with IC50s of 3/4/20/6/4 nM for MMP-1/2/3/7/9 respectively. Synonyms: BB-94 sodium salt; BB 94 sodium salt; BB94 sodium salt. Grade: >98%. CAS No. 130464-84-5. Molecular formula: C23H30N3NaO4S2. Mole weight: 499.62. | |
| Batoclimab | Batoclimab is a humanized monoclonal antibody targeting the neonatal Fc receptor (FcRn). Batoclimab binds to and inhibits FcRn, thus blocking the recycling of IgG antibodies. Batoclimab can be used in the research of pathogenic IgG-mediated autoimmune diseases. Synonyms: HBM9161; IMVT-1401. CAS No. 2187430-05-1. | |
| Baumycin C2 (Mixture of Diastereomers) | Baumycin C2 (Mixture of Diastereomers), an impurity of Daunorubicin and Doxorubicin, is an anthracycline antibiotic isolated from Streptomyces coeruleorubidus. Baumycin C2 shows antitumor activity. Synonyms: N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(1-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)formamide; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-10-[[2,3,6-trideoxy-3-(formylamino)-α-L-lyxo-hexopyranosyl]oxy]-. CAS No. 64479-55-6. Molecular formula: C28H31NO11. Mole weight: 557.55. | |
| Bavisant | Bavisant is a highly selective, orally active antagonist of the human H3 receptor. It is a novel mechanism of action, involving wakefulness and cognition. It has potential to be used as a treatment for ADHD. It was developed by Johnson & Johnson and has completed a phase II ADHD trial, but there has been no progress. Uses: Bavisant has potential to be used as a treatment for adhd. Synonyms: JNJ 31001074; JNJ-31001074; JNJ31001074; (4-Cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone. Grade: >98%. CAS No. 929622-08-2. Molecular formula: C19H27N3O2. Mole weight: 329.44. | |
| Bavisant dihydrochloride | Bavisant dihydrochloride is the dihydrochloride form of Bavisant, which is a highly selective, orally active antagonist of the human H3 receptor. It may be used as a treatment for ADHD. It was developed by Johnson & Johnson and has completed a phase II ADHD trial, but there has been no progress. Uses: Bavisant dihydrochloride may be used as a treatment for adhd. Synonyms: JNJ 31001074 dihydrochloride; JNJ-31001074 dihydrochloride; JNJ31001074 dihydrochloride; (4-Cyclopropylpiperazin-1-yl)(4-(morpholin-4-ylmethyl)phenyl)methanone dihydrochloride; Methanone, (4-cyclopropyl-1-piperazinyl)(4-(4-morpholinylmethyl)phenyl)-, hydrochloride (1:2). Grade: >98 %. CAS No. 929622-09-3. Molecular formula: C19H29Cl2N3O2. Mole weight: 402.36. | |
| Bavisant dihydrochloride hydrate | The dihydrochloride hydrate salt form of Bavisant which is an orally bioavaliable and selective H3 receptor antagonist that could probably useful in the treatment of Attention-deficit hyperactivity disorder(ADHD). It is known to have been completed the Ph. Uses: The dihydrochloride hydrate salt form of bavisant which is a h3 receptor antagonist that could probably useful in the treatment of attention-deficit hyperactivity disorder(adhd). Synonyms: Bavisant dihydrochloride; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC; UNII-C1H7H5X3RE; BAVISANT DIHYDROCHLORIDE; JNJ-31001074-AAC; 1103522-80-0; Bavisant dihydrochloride (USAN); Bavisant dihydrochloride [USAN]. Grade: 98%. CAS No. 1103522-80-0. Molecular formula: C19H31Cl2N3O3. Mole weight: 420.37. | |
| Bavituximab | Bavituximab is a chimeric monoclonal antibody that targets phosphatidylserine by binding to the phosphatidylserine-binding protein β2-glycoprotein 1 (β2GP1). Bavituximab has the potential for the treatment of cancers and viral infection. Synonyms: Tarvacin. Grade: 95%. CAS No. 648904-28-3. Molecular formula: C6446H9946N1702O2042S42. Mole weight: 145.3 kDa. | |
| BAW2881 | BAW 2881 is a VEGFR (vascular endothelial growth factor receptor) inhibitor (IC50 = 0.82, 0.037, and 0.42 μM for VEGFR1, 2, and 3, respectively).It can inhibit proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. Synonyms: BAW2881; BAW-2881; BAW 2881; NVP-BAW2881; NVP-BAW-2881; NVP-BAW 2881. 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide. Grade: 98%. CAS No. 861875-60-7. Molecular formula: C22H15F3N4O2. Mole weight: 424.38. | |
| Bax channel blocker | A direct allosteric inhibitor of BAX. Synonyms: BAI1. Grade: >98 %. CAS No. 335165-68-9. Molecular formula: C19H21Br2N3O. Mole weight: 467.20. | |
| Bax channel blocker dihydrochloride | Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Synonyms: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 329349-20-4. Molecular formula: C19H21Br2N3O.2HCl. Mole weight: 540.12. | |
| Baxdrostat | Baxdrostat is an aldosterone synthase inhibitor. Synonyms: N-[(8R)-4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide; (R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide; N-[(8R)-4-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)-5,6,7,8-tetrahydro-8-isoquinolinyl]propanamide; Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-. CAS No. 1428652-17-8. Molecular formula: C22H25N3O2. Mole weight: 363.45. | |
| Bay 02752 | Bay 02752 is a bio-active molecular, but no detailed information has been published yet. Synonyms: Bay-02752; Bay 02752; Bay02752; N,N'-(1,11-Undecanediyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide). Grade: 98%. CAS No. 78991-74-9. Molecular formula: C31H44N4O2. Mole weight: 504.71. | |
| BAY1125976 | BAY1125976 is a selective allosteric AKT1/2 inhibitor, which exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. In in vitro kinase activity assays, BAY 1125976 potently and selectively inhibited the activity of full-length AKT1 and AKT2 by binding into an allosteric binding pocket formed by kinase and PH domain. Synonyms: BAY-1125976; BAY 1125976. CAS No. 1402608-02-9. Molecular formula: C23H21N5O. Mole weight: 383.45. | |
| BAY-1142524 | BAY-1142524 is a chymase inhibitor. Chymase is an enzyme that modulates the production of proteins playing a role in adverse cardiac tissue remodeling and fibrogenesis. Study shows that BAY-1142524 could suppress the abnormal cardiac tissue remodeling after myocardial infarction (MI) and improves cardiac function. Uses: Abnormal cardiac tissue remodeling reduction. Synonyms: BAY-1142524; BAY 1142524; BAY1142524. | |
| BAY-1143572 | BAY 1143572 is a highly selective, potent and orally available inhibitor ofPTEFb/CDK9 and shows convincing anti-tumor activity in multiple xenograft models by the induction of apoptosis. Synonyms: 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine; BAY1143572; BAY 1143572; BAY-1143572. Atuveciclib. CAS No. 1414943-88-6. Molecular formula: C18H18FN5O2S. Mole weight: 387.43. | |
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grade: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. | |
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