BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AZ-3 | AZ-3 is a potent and selective inhibitor of JAK1 with an IC50 of 34 nM. Synonyms: 2,4-Pyrimidinediamine, N2-[2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-3-pyridinyl]-5-methyl-N4-[(1R)-1-methylpropyl]-; N4-[(2R)-2-Butanyl]-N2-{2-fluoro-5-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-3-pyridinyl}-5-methyl-2,4-pyrimidinediamine. Grade: ≥95%. CAS No. 2228908-91-4. Molecular formula: C20H28FN7. Mole weight: 385.48. |  |
| AZ304 | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grade: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ31 | AZ31 is a potent and highly selective ATM inhibitor with an IC50 of <1.2 nM. It displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR. AZ 31 also shows significant tumor growth reduction in the SW620 xenograft model combined with irinotecan. Synonyms: AZ 31; AZ-31; (S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide. Grade: ≥98%. CAS No. 2088113-98-6. Molecular formula: C24H28N4O3. Mole weight: 420.50. | |
| AZ 3146 | AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. Synonyms: AZ3146; AZ 3146; AZ-3146. Grade: >98%. CAS No. 1124329-14-1. Molecular formula: C24H32N6O3. Mole weight: 452.55. | |
| AZ32 | AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with IC50 of <6.2 nM for ATM enzyme and IC50 of 0.31 μM for ATM in cell. AZ32 is tolerated in C57Bl6 and Nude mice dosed orally at 200mg/kg which was efficacious in orthotopic mouse models. AZ32 is the first ATMi with oral bioavailability shown to radiosensitize glioma and improve survival in orthotopic mouse models. It also shows adequate selectivity over ATR and also has high cell permeability. Synonyms: AZ-32; AZ 32; N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide. Grade: ≥98%. CAS No. 2288709-96-4. Molecular formula: C20H16N4O. Mole weight: 328.37. | |
| Az-33 | Az-33 is a lactate dehydrogenase A (LDHA) inhibitor, which is a key enzyme in anaerobic glycolysis process and is deregulated in human malignancies. Uses: Az-33 is a lactate dehydrogenase a (ldha) inhibitor. Synonyms: Az 33; Az33; 2-(4-(4-((3-((2-Methylbenzo[d]thiazol-6-yl)amino)-3-oxopropyl)amino)-4-oxobutyl)benzyl)malonic acid. Grade: ≥98%. CAS No. 1370290-34-8. Molecular formula: C25H27N3O6S. Mole weight: 497.56. | |
| AZ 3451 | AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2) with IC50 of 23 nM. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1. The interaction of AZ3451 with PAR2 is predominately hydrophobic in nature. AZ3451 binds to a remote allosteric site outside the helical bundle, which prevents structural rearrangements required for receptor activation and signaling. Synonyms: 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide; AZ-3451; AZ3451. Grade: ≥98%. CAS No. 2100284-59-9. Molecular formula: C30H27BrN4O3. Mole weight: 571.46. | |
| AZ3976 | AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with IC50 of 26 μM in an enzymatic chromogenic assay. AZ3976 inhibited PAI-1 by enhancing the latency transition of active PAI-1. Synonyms: AZ 3976; AZ-3976. Grade: >98%. CAS No. 1418747-15-5. Molecular formula: C15H19N5O3. Mole weight: 317.34. | |
| AZ505 | AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ 505; AZ-505; N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide. Grade: 98%. CAS No. 1035227-43-0. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. | |
| AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 μM) with potential anticancer activity. Synonyms: AZ505 ditrifluoroacetate; AZ 505 ditrifluoroacetate; AZ-505 ditrifluoroacetate. Grade: >98%. CAS No. 1035227-44-1. Molecular formula: C33H40Cl2F6N4O8. Mole weight: 805.59. | |
| AZ506 | AZ506 is a potent SMYD2 inhibitor (IC50 = 17 nM) that inhibits SMYD2 methyltransferase activity in cells, resulting in a decrease in the SMYD2-mediated methylation signal. Synonyms: 3-Pyridinecarboxamide, 5-[2-[4-[2-(1H-indol-3-yl)ethyl]-1-piperazinyl]phenyl]-N-[3-(1-pyrrolidinyl)propyl]-; 5-(2-{4-[2-(1H-Indol-3-yl)ethyl]-1-piperazinyl}phenyl)-N-[3-(1-pyrrolidinyl)propyl]nicotinamide. Grade: ≥95%. CAS No. 2043321-54-4. Molecular formula: C33H40N6O. Mole weight: 536.71. | |
| AZ5104 | AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592. | |
| AZ 5704 | AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM in an enzyme inhibition assay. It exhibits 600-fold selectivity for ATM over other kinases. AZ 5704 is also orally bioavailable. Synonyms: 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide; AZ-5704; AZ5704. Grade: ≥98%. CAS No. 1941214-06-7. Molecular formula: C23H23FN6O2. Mole weight: 434.47. | |
| AZ6102 | AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-6. It also inhibits Wnt signaling in DLD-1 cells. IC50: TNKS2= 1 nM; TNKS1= 3 nM; Wnt signaling. Synonyms: 2-[4-[6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-oneAZ6102; AZ-6102; AZ 6102.AZ 6102|rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidi. CAS No. 1645286-75-4. Molecular formula: C25H28N6O. Mole weight: 428.53. | |
| AZ617 | AZ617 is a human-specific, TLR4-dependent agonist that activates NFκB. Synonyms: AZ-617; AZ 617. Grade: 98% by HPLC. CAS No. 2247439-36-5. Molecular formula: C40H38N4O4. Mole weight: 638.8. | |
| AZ 628 | AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grade: >98%. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
| AZ7371 | AZ7371 is a novel non-covalent inhibitor of decaprenylphosphoryl-D-ribose oxidase (DprE1) with IC50 of 10 nM. Synonyms: AZ-7371; AZ 7371; TBA-7371; DprE1-IN-1. Grade: 98%. CAS No. 1494675-86-3. Molecular formula: C18H21N5O3. Mole weight: 355.40. | |
| AZ7550 | AZ7550, an active metabolite of AZD9291, inhibits IGF1R activity with an IC50 of 1.6 μM in a cell-free assay. Synonyms: Osimertinib metabolite M3; 2-Propenamide, N-(4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-; N-(4-Methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-2-propenamide; N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide. Grade: ≥95%. CAS No. 1421373-99-0. Molecular formula: C27H31N7O2. Mole weight: 485.58. | |
| AZ7550 hydrochloride | AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits IGF1R activity with an IC50 of 1.6 μM in a cell-free assay. Synonyms: N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide hydrochloride (1:1); 2-Propenamide, N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 2309762-40-9. Molecular formula: C27H32ClN7O2. Mole weight: 522.04. | |
| AZ7550 Mesylate | AZ7550 Mesylate, an active metabolite of AZD9291, inhibits the activity of IGF1R with an IC50 of 1.6 μM. Synonyms: AZ7550 trimesylate salt; N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide methanesulfonate (1:3); 2-Propenamide, N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-, methanesulfonate (1:3). Grade: ≥98%. CAS No. 2319837-99-3. Molecular formula: C30H43N7O11S3. Mole weight: 773.90. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grade: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZ876 | AZ876 is a novel high-affinity LXR agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively, it was previously shown to inhibit progression of atherosclerosis in mice without incurring the aforementioned adverse effects. Whether AZ876 exerts additional protection in the heart remains to be explored. LXR activation with AZ876 attenuated this increase, and significantly reduced TAC-induced increases in heart weight, myocardial fibrosis, and cardiac dysfunction without affecting blood pressure. AZ876 was also 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human. Synonyms: AZ 876; AZ-876; AZ12260493; AZ 12260493; AZ-12260493. Grade: ≥98%. CAS No. 898800-26-5. Molecular formula: C24H29N3O3S. Mole weight: 439.57. | |
| AZ-960 | AZ-960 is an ATP-competitive inhibitor of JAK2 with Ki value of 0.45 nM. It inhibits proliferation in a SET-2 human megakaryoblastic cell line harboring the JAK2V617F mutation with GI50 value of 33 nM. Synonyms: (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 3-Pyridinecarbonitrile, 5-fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)-; 5-Fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]nicotinonitrile. Grade: >98%. CAS No. 905586-69-8. Molecular formula: C18H16F2N6. Mole weight: 354.36. | |
| AZA | ~4-fold increase in efficiency with OSKM and promotes full reprogramming. Uses: Reprogramming. Synonyms: 3'-Azido-2',3'-dideoxyadenosine; 66323-44-2; 3'-Azido-ddA; 3'-AzddAdo; [(2S,3S,5R)-5-(6-aminopurin-9-yl)-3-azidooxolan-2-yl]methanol; 3'-N3-ddA; [(2S,3S,5R)-5-(6-aminopurin-9-yl)-3-azido-tetrahydrofuran-2-yl]methanol; HG1022; 3'-Azido-2'-deoxyadenosine; CHEMBL590121; SCHEMBL18640424; DTXSID10216534; XDRZJDXXQHFAAE-RRKCRQDMSA-N; MFCD01630963; AKOS037644233; ((2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-azidotetrahydrofuran-2-yl)methanol; AS-49374; CS-0199753; A835421; 9-(3-Azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)adenine; 9-(3'-Azido-2',3'-dideoxy-.beta.-D-erythro-pentofuranosyl)adenine; 9-(3'-Azido-2',3'-dideoxy-beta-D-erythro-pentofuranosyl)adenine; [(2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-azidooxolan-2-yl]methanol; 9H-purin-6-amine, 9-(3-azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)-. Grade: ≥ 97%. CAS No. 66323-44-2. Molecular formula: C10H12N8O2. Mole weight: 276.26. | |
| Azacetidine Monoacetate | Azacetidine Monoacetate is an impurity of 5-Azacytidine, an antiproliferative/cytotoxic agent for leukemia therapy. Synonyms: ((2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl acetate; 1-(5-O-Acetyl-β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one. CAS No. 1174733-90-4. Molecular formula: C10H14N4O6. Mole weight: 286.24. | |
| Azamethiphos | Azamethiphos is a synthetic organic thiophosphate compound and organophosphate acetylcholinesterase inhibitor, mutagen, and neurotoxicant that is used as a pesticide. Uses: Synergistic insecticidal and acaricidal organophosphorus compound. Synonyms: S-((6-Chloro-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)methyl) O,O-dimethyl phosphorothioate; CGA 18809; Ciba-Geigy 18809; Salmosan; Snip; Phosphorothioic acid, S-[(6-chloro-2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)methyl] O,O-dimethyl ester; Azametiphos. Grade: 98%. CAS No. 35575-96-3. Molecular formula: C9H10ClN2O5PS. Mole weight: 324.68. | |
| Azapentacene | Azapentacene is used in ophthalmologic eye lotions containing polymers with side-chains of phosphorylcholine analogs. Synonyms: 5,12-Dihydro-quinoxalino[2,3-b]phenazine sulfonate sodium salt; Sodium 5,12-dihydroazapentacene disulfonate; Phacolysine Sodium Salt ; Phacolin; Quinax. Grade: > 95%. CAS No. 3863-80-7. Molecular formula: C18H10N4O6S2Na2. Mole weight: 488.41. | |
| Azaperol | Azaperol acts as a dopamine antagonist and also has antihistaminic and anticholinergic properties. Azaperol is commonly used as a butyrophenone neuroleptic drug in veterinary medicine. Synonyms: 1-(4-Fluorophenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-ol. CAS No. 2804-5-9. Molecular formula: C19H24FN3O. Mole weight: 329.419. | |
| Azaperone | Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. Synonyms: NSC 170976; NSC170976; NSC-170976. Grade: >98%. CAS No. 1649-18-9. Molecular formula: C19H22FN3O. Mole weight: 327.4. | |
| Azaphen | An antidepressant having effects on the autonomic nervous system; the drug is especially effective for mild and moderate depressions and a combination of Azaphen and Thymol is applicable for severa depressions. Azaphen improves sleep too. Synonyms: Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride. Grade: >98%. CAS No. 24853-80-3. Molecular formula: C16H21Cl2N5O. Mole weight: 370.28. | |
| Azaphen dihydrochloride monohydrate | Azaphen dihydrochloride monohydrate is a potent inhibitor of the reuptake of serotonin. It is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. Synonyms: Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate. Grade: >98%. CAS No. 63302-99-8. Molecular formula: C16H23Cl2N5O2. Mole weight: 388.29. | |
| Azapropazone | Azapropazone is a non-steroidal anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-; 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione; 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine; AHR 3018; Apazone; Cinnamin; Cinnopropazone; Mi 85; NSC 102824; Prolixan; Sinnamin. Grade: ≥95%. CAS No. 13539-59-8. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| Azapropazone dihydrate | Azapropazone dihydrate is a non-steroidal anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout. Synonyms: 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, hydrate (1:2); 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, dihydrate; 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine dihydrate; 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine dihydrate; 5-(dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione dihydrate. Grade: ≥95%. CAS No. 22304-30-9. Molecular formula: C16H20N4O2.2H2O. Mole weight: 336.39. | |
| Azaribine | It is an antineoplastic agent. Uses: Dermatologic agents. Synonyms: AZARIBINE; Triazure; 2169-64-4; 6-Azauridine 2',3',5'-triacetate; 6-Azaribine; CB 304; Azaribinum; Azaribina; Triacetyl-6-azauridine; 6-Azauridine triacetate; CB-304; NSC-67239; Azauridine triacetate; NSC 67239; K1U80DO9EB; MLS000069488; DTXSID1022635; TA-Azur; 2-beta-D-Ribofuranosyl-as-triazine-3,5(2H,4H)-dione 2',3',5'-triacetate; 1,2,4-Triazine-3,5(2H,4H)-dione, 2-(2,3,5-tri-O-acetyl-beta-D-rib. Grade: ≥95%. CAS No. 2169-64-4. Molecular formula: C17H20O6. Mole weight: 323.35. | |
| Azasetron hydrochloride | Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. Uses: Antiemetics. Synonyms: Azasetron hydrochloride; Y 25130; Y-25130; Y25130. Y-25130 HCl. Grade: >98%. CAS No. 123040-16-4. Molecular formula: C17H20ClN3O3.HCl. Mole weight: 386.27. | |
| Azatadine | Azatadine is a new antihistamine acts as histamine for histamine H1- receptor inhibitor ( IC50 = 6.5 nM and 10 nM, respectively). Uses: Antihistaminic. Synonyms: 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine; 2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3(8),4,6,11,13-hexaene. Grade: ≥98%. CAS No. 3964-81-6. Molecular formula: C20H22N2. Mole weight: 290.40. | |
| Azatadine Dimaleate | Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively. Uses: Histamine h1 antagonists. Synonyms: SCH10649; SCH 10649; SCH-10649. Grade: >98%. CAS No. 3978-86-7. Molecular formula: C20H22N2.2C4H4O4. Mole weight: 522.55. | |
| Azathioprine EP Impurity D | Azathioprine EP Impurity D is a metabolite of Azathioprine. Synonyms: 1-Methyl-4-nitro-5-thioimidazole; 1-Methyl-4-nitro-1H-imidazole-5-thiol; 5-Mercapto-1-methyl-4-nitroimidazole. Grade: > 95%. CAS No. 6339-54-4. Molecular formula: C4H5N3O2S. Mole weight: 159.17. | |
| Azathioprine EP Impurity E Sodium Salt | Azathioprine EP Impurity E Sodium Salt is a degradation product of Azathioprine. Synonyms: 5-Hydroxy-1-methyl-4-nitroimidazole Sodium Salt; 1-Methyl-4-nitro-1H-imidazol-5-ol Sodium Salt. Grade: > 95%. CAS No. 35681-68-6. Molecular formula: C4H4N3O3Na. Mole weight: 165.08. | |
| Azathioprine Impurity C | Azathioprine Impurity C is an impurity of 6-Mercaptopurine, which is an immunosuppressive drug used to treat leukemia. Synonyms: 6-Mercaptopurine Disulfide; 6,6'-Dithiodi-9H-purine; 6,6'-Dithiodi-purine; Bis(6-purinyl) disulfide; 1,2-Di(9H-purin-6-yl)disulfane; NSC 166569; NSC 77640. Grade: > 95%. CAS No. 49808-20-0. Molecular formula: C10H6N8S2. Mole weight: 302.34. | |
| AZD0156 | AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. Uses: Protein kinase inhibitors. Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one; AZD0156; AZD-0156; AZD 0156. CAS No. 1821428-35-6. Molecular formula: C26H31N5O3. Mole weight: 461.56. | |
| AZD-0284 | AZD-0284 is a reverse agonist of the nuclear receptor (RORγ). AZD-0284 has the potential for the treatment of plaque psoriasis vulgaris and respiratory tract disorders. Synonyms: AZD0284; AZD 0284. CAS No. 2101291-07-8. Molecular formula: C21H18F6N2O5S. Mole weight: 524.43. | |
| AZD 0328 | AZD 0328 is a potent α7 NNR/5HT3 receptor agonist. AZD0328 led to a significant increase in cortical dopamine release in awake rodents and improved both conditioned response learning and memory retention in an object recognition task. Synonyms: (3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]; AZD 0328; AZD-0328; AZD0328; UNII-2B218X5QIY; spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine). Grade: >98%. CAS No. 220099-91-2. Molecular formula: C13H16N2O. Mole weight: 216.28. | |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Synonyms: AZD-0364; AZD 0364; tizaterkib. Grade: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50. | |
| AZD0424 | AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor. It targets both Abl and Src kinases with potential antineoplastic activity. It selectively inhibits both Src and Abl kinase activity and may result in the inhibition of tumor growth in susceptible tumor cells. Uses: Azd0424 has the inhibition of tumor growth in tumor cells. Synonyms: AZD 0424; AZD-0424; 1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one; 7-(2-(4-Acetylpiperazin-1-yl)ethoxy)-4-(5-chloro-2,3-methylenedioxypyridin-4-ylamino)-5-isopropoxyquinazoline. Grade: 98%. CAS No. 692054-06-1. Molecular formula: C25H29ClN6O5. Mole weight: 528.99. | |
| AZD-0837 | AZD0837 is an oral direct thrombin inhibitor currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. Uses: Potassium channel antagonist. Synonyms: AZD0837; AZD-0837; AZD 0837; Atecegatran metoxil; Atecegatran fexenetil.1-((2R)-(3-chloro-5- (difluoromethoxy)phenyl)hydroxyacetyl)-N-((4-(imino(methoxyamino)methyl)phenyl)methyl)-, (2S)-2-Azetidinecarboxamide; (S)-1-((R)-2-(3-chloro-5-(difluoromethoxy)phenyl)-2-hydroxyacetyl)-N-(4-(N-methoxycarbamimidoyl)benzyl)azetidine-2-carboxamide. Grade: ≥95%. CAS No. 433937-93-0. Molecular formula: C22H23ClF2N4O5. Mole weight: 496.89. | |
| AZD1080 | AZD1080 is a brain-permeable GSK3 inhibitor with Ki values of 6.9 nM and 31 nM for GSK3α and GSK3β, respectively. Study showed that AZD1080 inhibited tau phosphorylation in cells. It also suppresses ovarian cancer cell proliferation, invasion, migration, and lamellipodia formation, and induces G1 arrest. Synonyms: AZD-1080; 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. Grade: >98%. CAS No. 612487-72-6. Molecular formula: C19H18N4O2. Mole weight: 334.37. | |
| AZD1152-HQPA | Barasertib is a potent and highly selective inhibitor of AURKB with IC50 of 0.37 nM, acting via preventing the transfer of the phosphate group from the ATP molecule to AURKB substrates. The present study demonstrated for the first time, that AURKB inhibition interferes with early regeneration of SGs. Barasertib has been demonstrated that it is 3,700-fold greater selectivity than Aurora A. Synonyms: INH 34; AZD1152-HQPA; AZD2811. Grade: ≥98%. CAS No. 722544-51-6. Molecular formula: C26H30FN7O3. Mole weight: 507.56. | |
| AZD-1208 | AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition. Synonyms: AZD1208; AZD 1208. Grade: 0.98. CAS No. 1204144-28-4. Molecular formula: C21H21N3O2S. Mole weight: 379.478. | |
| AZD1208 hydrochloride | AZD1208 (hydrochloride) is an orally bioavailable and highly selective PIM kinases inhibitor. CAS No. 1621866-96-3. Molecular formula: C21H22ClN3O2S. Mole weight: 415.94. | |
| AZD1283 | AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for 3 and 13, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds. On the basis of these data, compound 3 was progressed into human clinical trials as candidate drug AZD1283. Synonyms: AZD 1283; AZD-1283. Grade: 0.98. CAS No. 919351-41-0. Molecular formula: C23H26N4O5S. Mole weight: 470.544. | |
| AZD1305 | AZD1305 is a potassium channel and sodium channel antagonist. It can inhibit rapidly the activating delayed-rectifier potassium current, L-type calcium current, and inward sodium current. Phase II clinical trials for Arrhythmias, Atrial fibrillation, Atrial flutter and Left ventricular dysfunction were discontinued. Uses: Arrhythmias; atrial fibrillation; atrial flutter; left ventricular dysfunction. Synonyms: AZD-1305; AZD 1305; AZD1305; UNII-CZO834LXQM; UNII-CZO834LXQM; (2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester. Grade: 98%. CAS No. 872045-91-5. Molecular formula: C22H31FN4O4. Mole weight: 434.51. | |
| AZD1390 | AZD1390 is a first-in-class, orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. It can be used to cross the blood-brain barrier suitable for the treatment of intracranial malignancies. Synonyms: AZD-1390; AZD 1390. Grade: ≥98%. CAS No. 2089288-03-7. Molecular formula: C27H32FN5O2. Mole weight: 477.57. | |
| AZD-1480 | AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. Synonyms: AZD1480; AZD-1480; AZD 1480. Grade: 0.98. CAS No. 935666-88-9. Molecular formula: C14H14ClFN8. Mole weight: 348.77. | |
| AZD 1656 | AZD 1656 is a potent and selective glucokinase (GK) activator with the potential for the treatment of type 2 diabetes. Synonyms: (S)-3-(5-(Azetidine-1-carbonyl)pyrazin-2-yloxy)-5-(1-methoxypropan-2-yloxy)-N-(5-methylpyrazin-2-yl)benzamide. Grade: 99%. CAS No. 919783-22-5. Molecular formula: C24H26N6O5. Mole weight: 478.50. | |
| AZD-1678 | AZD-1678 is a potent CCR4 receptor antagonist with a pIC50 of 8.6. Synonyms: 2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide; Benzenesulfonamide, 2,3-dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)-. Grade: ≥95%. CAS No. 942137-41-9. Molecular formula: C11H8Cl2FN3O3S. Mole weight: 352.17. | |
| AZD1979 | This active molecular is a MCHr1 (melanin concentrating hormone receptor 1) antagonist originated by AstraZeneca. AZD1979 has excellent DMPK properties and gave good effects on weight loss in animal model. In Jul 2014, AstraZeneca terminated a phase I trial in Obesity in healthy volunteers in USA after stopping criteria were reached. Uses: Obesity. Synonyms: AZD1979; AZD-1979; AZD 1979. (3-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone. Grade: 98%. CAS No. 1254035-84-1. Molecular formula: C25H26N4O5. Mole weight: 462.51. | |
| AZD1981 | AZD1981, as a potent antagonist in a disease relevant cell system, inhibits DK-PGD2-induced CD11b expression in human eosinophils with IC50 of 10 nM. Synonyms: AZD1981; AZD 1981; AZD-1981. Grade: 98%. CAS No. 802904-66-1. Molecular formula: C19H17ClN2O3S. Mole weight: 388.866. | |
| AZD-2014 | AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. Synonyms: AZD2014, AZD-2014, AZD 2014, Vistusertib. Grade: 0.98. CAS No. 1009298-59-2. Molecular formula: C25H30N6O3. Mole weight: 462.554. | |
| AZD 2066 | AZD 2066 is a mGluR5 anatagonist. It displays discriminative effects in rats. It is brain penetrant and orally bioavailable. It is used to prevent and treat pain, psychiatric, neurological and other diseases. Synonyms: AZD 2066; AZD2066; AZD-2066; 4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine. Grade: ≥98% by HPLC. CAS No. 934282-55-0. Molecular formula: C19H16ClN5O2. Mole weight: 381.82. | |
| AZD 2066 hydrate | AZD 2066 hydrate is a selective and orally active antagonist of mGluR5. AZD 2066 hydrate has antinociception effects. Grade: ≥99%. Molecular formula: C19H18ClN5O3. Mole weight: 386.33. | |
| AZD 2098 | AZD 2098 is a potent and selective CCR4 receptor antagonist (pIC50 = 7.8) used for the treatment of allergic rhinitis. CCR4 is a molecule that can drive the immune cells toward the tumor cells. Uses: The treatment of allergic rhinitis and asthma. Synonyms: AZD-2098; AZD 2098; AZD2098; 2,3-dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide. Grade: 99%. CAS No. 566203-88-1. Molecular formula: C11H9Cl2N3O3S. Mole weight: 334.18. | |
| AZD2423 | AZD2423 is a potent, selective, orally bioavailable and non-competitive negative allosteric regulator of CCR2 chemokine receptor with an IC50 of 1.2 nM for CCR2 Ca2+ flux. Synonyms: N-(4-Chloro-3-fluorophenyl)-4-{[(2R)-4-(2-methyl-2-propanyl)-2-piperazinyl]carbonyl}-1-piperazinecarboxamide; 1-Piperazinecarboxamide, N-(4-chloro-3-fluorophenyl)-4-[[(2R)-4-(1,1-dimethylethyl)-2-piperazinyl]carbonyl]-; AZD-2423. Grade: ≥98%. CAS No. 1229603-37-5. Molecular formula: C20H29ClFN5O2. Mole weight: 425.93. | |
| AZD-2461 | AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. AZD2641 is currently in Phase I clinical study. The study is being conducted to see how it may work to treat solid tumors. The study will also assess the blood levels and action of AZD2461 in the body over a period of time and will indicate whether the drug has a therapeutic effect on solid tumors. Synonyms: AZD2461; AZD 2461. Grade: 0.98. CAS No. 1174043-16-3. Molecular formula: C22H22FN3O3. Mole weight: 395.434. | |
| AZD2716 | AZD2716 is a potent sPLA2 inhibitor (IC50 = 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively). When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 = 176 nM). Synonyms: AZD2716; AZD-2716; AZD 2716. (2R)-3-[3-(5-benzyl-2-carbamoylphenyl)phenyl]-2-methylpropanoic acid. Grade: 99%. CAS No. 1845753-81-2. Molecular formula: C24H23NO3. Mole weight: 373.44. | |
| AZD2858 | AZD2858 is a potent and selective GSK3β inhibitor with Ki value of 4.9 nM. It was shown to promote osteoblast differentiation in human adipose-derived stem cells (hADSC) in vitro. Synonyms: AZD-2858; 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide. Grade: >98%. CAS No. 486424-20-8. Molecular formula: C21H23N7O3S. Mole weight: 453.52. | |
| AZD 2858 hydrochloride | The hydrochloride salt form of AZD 2858. AZD 2858 is a potent and selective Glycogen Synthase Kinase-3β (GSK-3β; Ki = 4.9 nM) inhibitor used for Alzheimer's disease therapy with good BBB permeability in a bovine endothelial cell assay. AZD 2858 selectively inhibits GSK-3β-mediated tau phosphorylation (IC50 = 76 nM) in vitro. In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass by GSK-3 mediated inhibition of Wnt canonical signaling, making AZD2858 a possible therapeutic candidate for osteoporosis. Uses: The treatment of alzheimer's disease. Synonyms: AZD 2858 hydrochloride; AZD2858 hydrochloride; AZD-2858 hydrochloride; 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide hydrochloride. Grade: 98%. CAS No. 486424-21-9. Molecular formula: C21H23N7O3S.HCl. Mole weight: 489.98. | |
| AZD2906 | AZD2906 is a selective agonist of glucocorticoid receptor (GR) that increases micronucleus immature erythrocytes in rat bone marrow with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively. Synonyms: N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(6-methoxypyridin-3-yl)propan-2-yl)cyclopropanecarboxamide; Cyclopropanecarboxamide, N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(6-methoxy-3-pyridinyl)-1-methylethyl]-. Grade: ≥95%. CAS No. 1034148-15-6. Molecular formula: C26H25FN4O3. Mole weight: 460.50. | |
| AZD2932 | AZD2932 is a new quinazoline ether inhibitor and is a high affinity inhibitor of VEFGR-2 and PDGFR. It has a balanced ~1:1 ratio of activity vs both VEGFR-2 and PDGFRβ. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. Synonyms: AZD2932; AZD 2932; AZD-2932. Grade: >98%. CAS No. 883986-34-3. Molecular formula: C24H25N5O4. Mole weight: 447.49. | |
| AZD-3147 | AZD-3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2. It exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. It has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. Uses: Azd-3147 has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. Synonyms: AZD3147; AZD-3147; AZD 3147; (S)-1-(4-(4-(1-(cyclopropylsulfonyl)cyclopropyl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-hydroxyethyl)thiourea. Grade: >98%. CAS No. 1101810-02-9. Molecular formula: C24H31N5O4S2. Mole weight: 517.66. | |
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