BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Atracurium Besilate EP Impurity D | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 1-(3,4-dimethoxybenzyl)-2-[3-[(5-hydroxypentyl)oxy]-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium benzenesulfonate; Atracurium Besylate Impurity D; (R)-Laudanosine N-3-((5-Hydroxypentyl)oxy)-3-oxopropyl Benzenesulfonate. Molecular formula: C35H47NO10S. Mole weight: 673.82. |  |
| Atracurium Besilate EP Impurity E | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 2-(2-carboxyethyl)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium benzenesulfonate; Atracurium Besylate Impurity E. Molecular formula: C30H37NO9S. Mole weight: 587.68. | |
| Atracurium Besilate EP Impurity F | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium benzenesulfonate; Atracurium Besylate Impurity F. Molecular formula: C28H35NO7S. Mole weight: 529.65. | |
| Atracurium Besilate EP Impurity G | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: Laudanosine; DL-Laudanosine; (+-)-Laudanosine; 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; Atracurium Besylate Impurity G. CAS No. 1699-51-0. Molecular formula: C21H27NO4. Mole weight: 357.44. | |
| Atracurium Besilate EP Impurity H | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 2,2'-((hexane-1,6-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) dibenzenesulfonate; tracurium Besylate Impurity H. Molecular formula: C66H84N2O18S2. Mole weight: 1257.51. | |
| Atracurium Besilate EP Impurity I | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 2,2'-[(3-methylpentane-1,5-diyl)bis[oxy(3-oxopropane-1,3-diyl)]]bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] dibenzenesulfonate; Atracurium Besylate Impurity I. Molecular formula: C66H84N2O18S2. Mole weight: 1257.51. | |
| Atracurium Besilate EP Impurity K | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 2,2'-[hexane-1,5-diylbis[oxy(3-oxopropane-1,3-diyl)]]bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] dibenzenesulfonate; Atracurium Besylate Impurity K. Molecular formula: C66H84N2O18S2. Mole weight: 1257.51. | |
| Atracurium Besylate | Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg. Synonyms: Norlaudanosine HCl. Grade: >98%. CAS No. 64228-81-5. Molecular formula: C53H72N2O12·2(C6H5O3S). Mole weight: 1243.48. | |
| Atracurium Besylate EP impurity B (Oxalate Salt) | Atracurium Besylate EP impurity B (Oxalate Salt) is an impurity of Atracurium Besylate, a neuromuscular blocking agent used during surgeries and for mechanical ventilation. Synonyms: (R)-Pentane-1,5-diyl bis(3-((R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate) dioxalate; CisAtracurium Oxalate; Atracurium Besylate EP impurity B (Oxalate Salt); (1R,1'R)-2,2'-(3,11-Dioxo-4,10-dioxatridecamethylene)-bis-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquindline)-dioxalate; Atracurium dioxalate; 5-[3-[(1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]propanoyloxy]pentyl 3-[(1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]propanoate; oxalic acid; cis-Atracurium oxalate; SCHEMBL8949609; WDA68752; MFCD11973631; BS-50869; CS-0186139; F15234; Q-101019; (R)-Pentane-1,5-diylbis(3-((R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propanoate)dioxalate. Grade: 95%. CAS No. 96687-52-4. Molecular formula: C55H70N2O20. Mole weight: 1079.15000. | |
| Atracurium Impurity 1 | Atracurium Impurity 1 is an impurity of atracurium besylate, a non-depolarizing neuromuscular blocker contributing to improved patient care and surgical procedures. Synonyms: (R)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-ium iodide; Atracurium Impurity 1; starbld0007530; (R)-N-Methyl-Laudanosine Iodide; (1R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2,2-dimethyl-3,4-dihydro-1H-isoquinolin-2-ium; iodide. Grade: > 95%. CAS No. 41431-32-7. Molecular formula: C22H30NO4I. Mole weight: 499.39. | |
| Atracurium Impurity 5 | Atracurium Impurity 5 is intermediate for the synthesis of neuromuscular blocking agents. Synonyms: N-Methyllaudanosine; 5'-Methoxylaudanosine; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline; 6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline. Grade: > 95%. CAS No. 24734-71-2. Molecular formula: C22H29NO5. Mole weight: 387.48. | |
| Atracurium Impurity V (Mixture of Diastereomers) | Atracurium Impurity V (Mixture of Diastereomers) is an impurity of Atracurium, a neuromuscular blocking agent widely used in anesthesia. Synonyms: 1-Ethylveratrole-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline N-Methyl Propanoate Iodide. Grade: > 95%. CAS No. 1075726-86-1. Molecular formula: C25H34NO6I. Mole weight: 571.45. | |
| Atracurium Quaternary Acid | An impurity of Atracurium besilate. Atracurium besilate is a non-neuromuscular-blocking agent used to relax skeletal muscle. Synonyms: 2-(2-Carboxyethyl)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium. Grade: ≥95%. CAS No. 99469-29-1. Molecular formula: C24H32NO6. Mole weight: 430.51. | |
| Atrasentan | atrasentan hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Synonyms: US brand name: Xinlay; Code names: (+)-A 127722; ABT-627; ABT627; A 127722; A127722; A-127722; Xinlay; ABT 627; NSC720763; NSC 720763; NSC-720763. CAS No. 173937-91-2. Molecular formula: C29H38N2O6. Mole weight: 510.631. | |
| Atrasentan hydrochloride | Atrasentan hydrochloride is the hydrochloride salt form of Atrasentan. Atrasentan, also called as ABT-627, is a selective and orally available antagonist of ETA receptor with potent antitumour activity. Synonyms: Atrasentan Hydrochloride; Atrasentan HCl; A 147627; A-147627; A147627; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid; hydrochlorideAtrasentan hydrochlorideAtrasentan HCl195733-43-8Atrasentan (hydrochloride)UNII-E4G31X93ZAAbbott 147627Atrasentan hydr. Grade: 95%. CAS No. 195733-43-8. Molecular formula: C29H39ClN2O6. Mole weight: 547.08. | |
| Atreleuton | Atreleuton, a kind of urea compound, has been found to be a 5-lipoxygenase inhibitor as well as Leukotriene B4 receptor antagonist that could probably be useful in study of sorts of diseases like asthma and acute coronary syndromes. It has already been discontinued by VIA Pharmaceuticals. Uses: Lipoxygenase inhibitors. Synonyms: Atreleuton; ABT-761; ABT 761; VIA 2291; VIA-2291; VIA2291; A-85761; Abbott-85761; Atreleuton [USAN]; UNII-U301T88E1M; ABT 761; 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. Grade: 98%. CAS No. 154355-76-7. Molecular formula: C16H15FN2O2S. Mole weight: 318.37. | |
| Atreleuton Glucuronide | Atreleuton Glucuronide is an esteemed compound of profound significance, used for studying afflictions of inflammation and autoimmune disorders. Its unparalleled prowess lies in the inhibition of 5-lipoxygenase activity, thereby efficaciously studying the research and development of leukotrienes. Molecular formula: C22H22FN2O8S. Mole weight: 493.48. | |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| ATR-IN-10 | ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC50 value of 2.978 μM. Synonyms: ATR-IN-10; CHEMBL5188769; BDBM50603737; HY-144214; CS-0378512; 2713577-93-4. CAS No. 2713577-93-4. Molecular formula: C27H24N4O. Mole weight: 420.51. | |
| ATR-IN-4 | ATR-IN-4 is a potent ATR inhibitor. It inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41.33 nM, respectively. CAS No. 2574545-45-0. Molecular formula: C18H20N8O. Mole weight: 364.40. | |
| ATR inhibitor 1 | ATR inhibitor 1 is an ATR inhibitor and has a Ki value below 1 μΜ. CAS No. 1613200-51-3. Molecular formula: C16H12F2N8O. Mole weight: 370.32. | |
| Atropine impurity E | Anisodamine is a alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine by binding in brain membrane preparations. Uses: A weak antagonist of α1-adrenoceptors. Synonyms: 654-II; 654II; 654 II; 7-hydroxyhyoscyamine; 6-Hydroxy hyoscyamine; αS-(hydroxymethyl)-benzeneacetic acid, (1R,?3S,?5R,?6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]?oct-3-yl ester. Grade: ≥98%. CAS No. 55869-99-3. Molecular formula: C17H23NO4. Mole weight: 305.37. | |
| Atropine methyl bromide | Atropine methyl bromide is a muscarinic receptor (mAChR) antagonist. Atropine methyl bromide is used in the inhibition of prostaglandin EP2 receptor accelerating functional recovery after neurodegeneration and brain inflammation. Synonyms: 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide (1:1), (3-endo)-; 1αH,5αH-Tropanium, 3α-hydroxy-8-methyl-, bromide, (±)-tropate; 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, (3-endo)-; 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, endo-(±)-; 8-Methylatropinium bromide; 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-, bromide, endo-; Atropine methobromide; Hyoscyamine methyl bromide; Methylatropine bromide; Methylatropinium bromide; Mintussin; Mydriasin; N-Methylatropine bromide; N-Methylatropinium bromide; NSC 61810; Tropin. Grade: ≥95%. CAS No. 2870-71-5. Molecular formula: C18H26NO3.Br. Mole weight: 384.31. | |
| Atropine sulfate hydrate (2:1:1) | Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery. Uses: Adjuvants, anesthesia. Synonyms: Atropine sulfate monohydrate; Atropini sulfas; Isopto Atropine; Atropinum sulphuricum; Atropine sulfate. Grade: >98%. CAS No. 5908-99-6. Molecular formula: 2C17H23NO3.H2O4S.H2O. Mole weight: 694.837. | |
| Atropine sulfate hydrate (2:1:2) | Atropine sulfate hydrate (2:1:2) is a pharmaceutically significant compound extensively utilized in the biomedical domain, serving as an efficacious muscarinic antagonist for the research of diverse medical ailments encompassing hypersecretion of saliva, bradycardia and specific gastrointestinal disorders. Uses: Adjuvants, anesthesia. Synonyms: endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate sulfate dihydrate(2:1:2). CAS No. 73791-47-6. Molecular formula: 2C17H23NO3.H2O4S.2H2O. Mole weight: 712.852. | |
| Atrovastatin-PEG3-FITC | Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor and it acts as a ligand in fluorescence anisotropy assay. CAS No. 1440755-31-6. Molecular formula: C64H68FN5O12S. Mole weight: 1150.31. | |
| Atuliflapon | Atuliflapon is a novel 5-lipoxygenase activating protein (FLAP) inhibitor for the treatment of coronary artery disease. Synonyms: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide; AZD5718; Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-; AZD-5718; AZD 5718. Grade: ≥98% by HPLC. CAS No. 2041075-86-7. Molecular formula: C24H26N6O3. Mole weight: 446.50. | |
| Atuveciclib S-Enantiomer | Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor with an IC50 of 16 nM for CDK9/CycT1. Synonyms: BAY-1143572 S-Enantiomer; (S)-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine; 4-(4-Fluoro-2-methoxyphenyl)-N-{3-[(S-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine. Grade: ≥95%. CAS No. 250279-81-1. Molecular formula: C18H18FN5O2S. Mole weight: 387.43. | |
| Atuzabrutinib | Atuzabrutinib is a Bruton's tyrosine kinase inhibitor. Synonyms: (2E)-2-{(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4,4-dimethylpent-2-enenitrile; 1-Piperidinepropanenitrile, 3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-α-(2,2-dimethylpropylidene)-β-oxo-, (αE,3R)-; (R,E)-2-(3-(4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-4,4-dimethylpent-2-enenitrile. CAS No. 1581714-49-9. Molecular formula: C30H30FN7O2. Mole weight: 539.61. | |
| AU-12122 | AU-12122 is a novel-developed CDK7 inhibitor, which is potent and orally bioactive. It induces apoptosis of acute monocytic leukemia THP-1. Uses: The potential treatment of acute monocytic leukemia. Synonyms: AU-12122; AU 12122; AU12122. | |
| AU1235 | AU1235, an adamantyl urea derivative, is an inhibitor of Mycobacterium tuberculosis that was active on MDR strains and had a bactericidal effect on replicating bacteria. Synonyms: AU1235; AU 1235; AU-1235; 1-(1-adamantyl)-3-(2,3,4-trifluorophenyl)urea; 1-(2-adamantyl)-3-(2,3,4-trifluorophenyl)urea. CAS No. 1338780-86-1. Molecular formula: C17H19F3N2O. Mole weight: 324.34. | |
| AU-15330 | AU-15330 is highly specific and VHL-dependent PROTAC degrader of the SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1). It induces effective inhibition of tumour growth in xenograft models of prostate cancer and acts synergistically with enzalutamide, an AR antagonist. It induces disease remission in castration-resistant prostate cancer (CRPC) models and is nontoxic. Synonyms: AU 15330; AU15330; (2S,4R)-1-((S)-2-(2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide. Grade: ≥95%. CAS No. 2380274-50-8. Molecular formula: C39H49N9O5S. Mole weight: 755.93. | |
| AUDA | AUDA is an inhibitor of soluble epoxide hydrolase with IC50 of 18 nM in mice. AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. AUDA can activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ. AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways. Synonyms: 12-(3-Adamantan-1-yl-ureido)dodecanoic Acid; 12-[[(Tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]dodecanoic Acid; A 003564556. Grade: >98%. CAS No. 479413-70-2. Molecular formula: C23H40N2O3. Mole weight: 392.6. | |
| AUNP-12 | AUNP-12 is highly effective in antagonizing PD-1 signaling, with desirable in vivo exposure upon subcutaneous dosing. It inhibits tumor growth and metastasis in preclinical models of cancer and is well tolerated with no overt toxicity at any of the tested doses. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs) thereby diminishing their activity. AUDA is an inhibitor of sEH exhibiting IC50 of 18 nM for the mouse and IC50 of 69 nM forand human enzymes. Synonyms: Aur-012; Aurigene-012; Aurigene NP-12. Grade: ≥95%. CAS No. 1353563-85-5. Molecular formula: C142H226N40O48. Mole weight: 3261.55. | |
| Auranofin | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Synonyms: SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162; Ridaura; NSC 321521, Ridauragold thiol; Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-; [1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold; Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate; Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-; β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex; [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold; Aktil; Crisinor; Crisofin Gold Salt; Ridauran; SKF 39162D. Grade: ≥98%. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.49. | |
| Auranofin-13C6 | Auranofin-13C6 is a labelled analogue of Auranofin, a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase. Synonyms: [1-(Thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold-13C6; 2,3,4,6-Tetraacetate(1-thio-β-D-glucopyranosato)(triethylphosphine)-gold-13C6; Aktil-13C6; Auranofin-13C6; Crisinor-13C6; Crisofin-13C6; NSC 32152-13C6; Ridaura-13C6; Ridauran-13C6; SKF 39162-13C6; SKF 39162D-13C6; [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold-13C6. Molecular formula: C14[13C]6H34AuO9PS. Mole weight: 684.44. | |
| Auriclosene | Auriclosene is a potent and Broad spectrum antimicrobial agent. It is highly effective in in vitro studies against multi-drug resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE). Phase III clinical trials for the treatment of Impetigo are on-going. Uses: Impetigo. Synonyms: NVC-422; NVC 422; NVC422; CD07223; CD-07223; CD 07223; Auriclosene. UNII-BKR7Y95229; 2-(dichloroamino)-2-methylpropane-1-sulfonic acid. Grade: 98%. CAS No. 846056-87-9. Molecular formula: C4H9Cl2NO3S. Mole weight: 222.08. | |
| Aurintricarboxylic acid | Aurintricarboxylic acid acts as a histological dye and an insulin-like growth factor receptor 1 antagonist. Synonyms: 1,4-cyclohexadiene-1-carboxylic acid, 3-(bis(3-carboxy-4-hydroxyphenyl)methylen; aluminon free acid. Grade: 95%. CAS No. 4431-00-9. Molecular formula: C22H14O9. Mole weight: 422.34. | |
| Aurora A Inhibitor I | Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM. It is 1000-fold more selective for Aurora A than Aurora B. Synonyms: TC-S 7010; TC S 7010; TCS7010. Grade: >98%. CAS No. 1158838-45-9. Molecular formula: C31H31ClFN7O2. Mole weight: 588.07. | |
| Aurora A inhibitor II | Aurora A inhibitor II is a potent and selective inhibitor of Aurora A kinase (AurA; IC50 = 4.3 nM). Synonyms: 4-[[2-[[4-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-N-(2-chlorophenyl)-Benzamide. Grade: 99%. CAS No. 1158838-43-7. Molecular formula: C31H29ClFN7O3. Mole weight: 602.06. | |
| Aurora B inhibitor 1 | Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor. It also inhibits JAK3 and JAK2. Synonyms: Methanone, (5-chloro-2-fluorophenyl)?[(3S)?-3-[[4-(3-cyclopropyl-3-fluoro-1-azetidinyl)?-6-[(5-methyl-1H-pyrazol-3-yl)?amino]?-2-pyrimidinyl]?oxy]?-1-pyrrolidinyl]?-. CAS No. 937276-52-3. Molecular formula: C25H26ClF2N7O2. Mole weight: 529.97. | |
| Aurora inhibitor 1 | Aurora inhibitor 1 is a potent Aurora inhibitor (IC50 = 4 nM and 13 nM for Aurora A and Aurora B kinase). CAS No. 2227019-45-4. Molecular formula: C23H25N9S. Mole weight: 459.57. | |
| Aurora Kinase Inhibitor II | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A with IC50 of 0.39 μM. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. This compound has the ability to permeate the cell and is involved in the regulation of the cell cycle, particularly cell division. Synonyms: 4-(4?-Benzamidoanilino)-6,7-dimethoxyquinazoline. Grade: ≥98%. CAS No. 331770-21-9. Molecular formula: C23H20N4O3. Mole weight: 400.4. | |
| Aurora Kinase Inhibitor III | Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies. Synonyms: Aurora Kinase Inhibitor III; AKI-7169; AKI 7169; AKI7169. Grade: ≥98%. CAS No. 879127-16-9. Molecular formula: C21H18F3N5O. Mole weight: 413.4. | |
| Aurothioglucose | Aurothioglucose is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: AUROTHIOGLUCOSE; Solganal; 12192-57-3; Gold thioglucose; Aurothioglucose 80%; Aurothioglucose hydrate; Solganol; Gold(1+); 3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-thiolate; gold(1+); (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-thiolate; DTXSID5046013; NCGC00096015-01; Spectrum_001866; NSC-759601; KBioSS_002383; SPECTRUM1500132; DTXCID3026013; KBio2_002379; KBio2_004947; KBio2_007515; HMS2091K17; Pharmakon1600-01500132; Tox21_111549; NSC759601; CCG-213700; PD057378; SBI-0206666.P002; CAS-12192-57-3; AB00053375_02; SR-05000001568; SR-05000001568-1; BRD-A89825407-001-01-8. Grade: >98%. CAS No. 12192-57-3. Molecular formula: C6H11AuO5S. Mole weight: 392.18. | |
| Aurothioglucose-13C6 | Aurothioglucose-13C6 is a labelled analogue of Aurothioglucose, which is used in the treatment of rheumatoid arthritis and psoriasis. Synonyms: [1-(thio-κS)-D-Glucopyranosato-κO2]-gold-13C6; 1-thio-D-Glucose S-gold Derivative-13C6; (1-thio-D-Glucopyranosato)-Gold-13C6; (1-thio-D-Glucopyranosato-O2,S1)gold-13C6; 1-thio-D-Glucopyranose Gold Complex-13C6; (D-Glucopyranosylthio)gold-13C6; Aureotan-13C6; Auromyose-13C6; Aurothioglucose-13C6; Aurumine-13C6; Authron-13C6; Brenol-13C6; 1-thio-Glucose Gold Salt (1:1)-13C6; Glysanol B-13C6; Gold Thioglucose-13C6; (D-Glucopyranosylthio)gold-13C6; Oronol-13C6; Solganal-13C6; Solganal B-13C6. Grade: 70% by HPLC; 98.7% atom 13C. Molecular formula: [13C]6H11AuO5S. Mole weight: 398.14. | |
| AUT1 | AUT1 is a modulator of recombinant human Kv3 channel. Synonyms: AUT-1; AUT 1. Grade: 98% by HPLC. CAS No. 1311136-84-1. Molecular formula: C18H19N3O4. Mole weight: 341.4. | |
| AUTAC1 | AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC), which contains a degradation tag and a warhead to provide target specificity. It is composed of an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety, with the Fumagillol binding covalently to MetAP2. AUTAC1 has potential anticancer activity as it can degrade MetAP2 and FKBP12 proteins and is used in the synthesis of PROTACs. This compound represents a novel targeted-clearance strategy that harnesses the autophagy-lysosome pathway for the degradation of specific proteins, expanding the scope of targeted protein degradation beyond the limitations of proteasomal clearance. Synonyms: (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl ((R)-4-(((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)methyl)-2,5-dioxo-10,13,16-trioxa-3,6-diazanonadecan-19-yl)carbamate; 6,9,12-Trioxa-2,16,19-triazaheneicosanoic acid, 18-[[[2-amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-17,20-dioxo-. Grade: ≥95%. CAS No. 2241669-09-8. Molecular formula: C44H63FN8O11S. Mole weight: 931.08. | |
| Autogramin-1 | Autogramin-1 is a novel autophagy inhibitor that selectively targets the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A), and directly competes with cholesterol binding to the GRAMD1A StART domain. Synonyms: Autogramin 1; Autogramin1. Grade: >98%. CAS No. 2375541-73-2. Molecular formula: C23H27N5O5S. Mole weight: 485.56. | |
| Autophagy-IN-C1 | Autophagy-IN-C1 can induce apoptosis and block autophagy in hepatocellular carcinoma (HCC) cells. Synonyms: Autophagy-IN-C1; CHEMBL5082200; HY-141813; CS-0226365; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)urea. Molecular formula: C29H28F6N4O2. Mole weight: 578.55. | |
| Autophinib | Autophinib is a novel potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin with IC50 values of 0.04 μM and 0.09 μM, respectively. Synonyms: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine. CAS No. 1644443-47-9. Molecular formula: C14H11ClN6O3. Mole weight: 346.73. | |
| Auxinole | Auxinole is a potent TIR1 antagonist. Auxinole binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex, suppressing auxin-responsive gene expression. Synonyms: BS-45814; HY-111444. Grade: 99%. CAS No. 86445-22-9. Molecular formula: C20H19NO3. Mole weight: 321.37. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grade: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| AV-153 | AV-153, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 3,5-Diethyl 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-3,4,5-pyridinetricarboxylate monosodium salt; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-, 3,5-diethyl ester, monosodium salt; 2,6-Dimethyl-1,4-dihydro-3,5-bis(ethoxycarbonyl)pyridine-4-carboxylic acid sodium salt; Sodium 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylate. CAS No. 27296-05-5. Molecular formula: C14H18NNaO6. Mole weight: 319.29. | |
| AV-153 free base | AV-153 free base, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; 3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylic acid; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester; 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid. Grade: ≥95%. CAS No. 19350-66-4. Molecular formula: C14H19NO6. Mole weight: 297.30. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| AV-412 Tosylate | AV-412 is a dual EGFR/ErbB2 kinase inhibitor. It completely inhibits the tumor growth of both H1650 and H1975 xenografts in nude mice. It is proved that AV-412 suppresses tumor growth via the inhibition of EGFR. Besides that, AV-412 also shows antitumor effects against various tumor models expressing EGFR, ErbB2 or both receptors, such as breast cancer KPL-4, prostate cancer DU145 and lung cancer LC-376. Uses: Antineoplastic agents. Synonyms: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate); MP-412; MP 412; MP412; AV-412; AV 412; AV412; AV-412 tosylate. Grade: >98%. CAS No. 451493-31-5. Molecular formula: C41H44ClFN6O7S2. Mole weight: 851.41. | |
| Ava10-Terlipressin | An impurity of Terlipressin. Terlipressin is a synthetic vasopressin analogue primarily used to improve kidney function in adults with hepatorenal syndrome (HRS), a condition that causes kidney problems in individuals with severe liver disease. It acts as a vasoconstrictor, predominantly in the splanchnic circulation, which helps increase arterial pressure and reduce portal venous pressure. Synonyms: Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2(Cys4&Cys9 bridge); [Ava10]-Terlipressin; GGGCYFQNC-Ava-KG-NH2(Cys4&Cys9 bridge); Ava(10)-Terlipressin; [5-Aminovaleric acid]10-Terlipressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9); Glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-5-aminopentanoate-L-lysyl-glycinamide (4->9)-disulfide. Grade: ≥95%. Molecular formula: C52H76N16O15S2. Mole weight: 1229.39. | |
| Ava23-Calcitonin (salmon) | An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Ava-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); Ava Calcitonin; [Ava23]-Calcitonin (salmon); CSNLSTCVLGKLSQELHKLQTY-Ava-RTNTGSGTP-NH2(Cys1&Cys7 bridge); L-Cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-5-aminopentanoate-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide; Proline ring opening calcitonin (salmon); Calcitonin (salmon) (Proline ring opening); [5-Aminovaleric acid]23-calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H242N44O48S2. Mole weight: 3433.91. | |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grade: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. | |
| Avanafil Impurity 13 | Avanafil Impurity 13 is an impurity of Avanafil, a medication prescribed for treating erectile dysfunction. Synonyms: 1,4,5,6-tetrahydropyrimidin-2-ylmethanamine; Avanafil Related Compound 1. Grade: > 95%. CAS No. 759408-08-7. Molecular formula: C5H11N3. Mole weight: 113.16. | |
| Avanafil metabolite M4 | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grade: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
| Avanafil Related Compound 1 | Avanafil Related Compound 1 is a pivotal entity within the biomedical research, primarily employed in the synthesand exploration of Avanafil, a pharmaceutical intervention targeting erectile dysfunction. Synonyms: 4-(3-chloro-4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylsulfinylpyriMidine; Ethyl 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(Methylsulfinyl)pyriMidine-5-carboxylate. Grade: > 95%. CAS No. 330785-82-5. Molecular formula: C16H18ClN3O4S. Mole weight: 383.86. | |
| Avapritinib | BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Synonyms: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; BLU-285; BLU 285; BLU285; UNII-513P80B4YJ; SCHEMBL16652297. CAS No. 1703793-34-3. Molecular formula: C26H27FN10. Mole weight: 498.56. | |
| Avarofloxacin hydrochloride | Avarofloxacin hydrochloride is an antibacterial drug agent. Uses: Avarofloxacin hydrochloride is an antibacterial drug agent. Synonyms: Avarofloxacin HCl; JNJ-Q2 hydrochloride; 7-[(3E)-3-(2-amino-1-fluoroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid hydrochloride; JNJ-32729463 hydrochloride; JNJ 32729463 hydrochloride. Grade: >98 %. CAS No. 1001162-01-1. Molecular formula: C21H24ClF2N3O4. Mole weight: 455.89. | |
| Avasimibe | Avasimibe inhibits Lipoprotein(a) accumulation in the culture media of primary monkey hepatocyte in a dose-dependent manner with 11.9% -31.3% inhibition, the change is mainly associated with decreased ApoA. Uses: Cytochrome p-450 cyp3a inducers. Synonyms: CI-1011; CI 1011; CI1011; ((2,4,6-Tris(1-methylethyl)phenyl)acetyl)sulfamic acid 2,6-bis(1-methylethyl)phenyl este; Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl esterr. Grade: >98%. CAS No. 166518-60-1. Molecular formula: C29H43NO4S. Mole weight: 501.72. | |
| Avatrombopag | Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 is an orally-active TPO receptor agonist that may be useful in the treatment of patients with thrombocytopenia. Synonyms: AKR-501; AKR 501; AKR501; YM477; YM-477; YM 477; E5501; AS 1670542; AS1670542; AS-1670542. Grade: 98%. CAS No. 570406-98-3. Molecular formula: C29H34Cl2N6O3S2. Mole weight: 649.65. | |
| Avatrombopag hydrochloride | Avatrombopag hydrochloride is a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. Synonyms: Avatrombopag (hydrochloride). Grade: 98%. CAS No. 570403-17-7. Molecular formula: C29H35Cl3N6O3S2. Mole weight: 686.12. | |
| Avatrombopag maleate | Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 is an orally-active TPO receptor agonist that may be useful in the treatment of patients with thrombocytopenia. CAS No. 677007-74-8. Molecular formula: C33H38Cl2N6O7S2. Mole weight: 765.7. | |
| AVB-S6-500 | AVB-S6-500 is a GAS6-AXL signaling pathway blocker with high affnity for GAS6. AVB-S6-500 is developed for the treatment of cancer and nonmalignant fibrotic conditions as a drug candidate. It is in a phase I clinical trial for its safety and tolerability study. Uses: Potential treatment of cancer and nonmalignant fibrotic conditions. Synonyms: Aravive-S6. | |
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