BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Arzoxifene | Arzoxifene, also known as LY353381, a synthetic aromatic derivative with anti-estrogenic properties, displays greater bioavailability and higher anti-estrogenic potency in the breast than another selective estrogen receptor modulators (SERMs),raloxifene. Synonyms: 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol; 4'F-DMA; 182133-27-3 (hydrochloride salt); arzoxifene; LY 353381; LY-353381; LY353381. Grade: >98%. CAS No. 182133-25-1. Molecular formula: C28H29NO4S. Mole weight: 475.60. |  |
| AS-041164 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grade: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
| AS101 | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Synonyms: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001; WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101; US brand name: Ossirene; IVX-Q-101. Ammonium trichloro(dioxoethylene-O,O') tellurate. CAS No. 106566-58-9. Molecular formula: C2H4Cl3O2Te.H4N. Mole weight: 312.049. | |
| AS 1269574 | GPR119 has been found to be a GPR119 agonist and could stimulate the activity of proglucagon gene promoter. Synonyms: AS1269574; AS-1269574; AS 1269574; 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol. Grade: ≥98% by HPLC. CAS No. 330981-72-1. Molecular formula: C13H14BrN3O. Mole weight: 308.17. | |
| AS 1517499 | AS 1517499 is a potent and selective STAT6 inhibitor (IC50 = 21 nM). Synonyms: AS-1517499; AS1517499; AS 1517499. 4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide. Grade: 99%. CAS No. 919486-40-1. Molecular formula: C20H20ClN5O2. Mole weight: 397.86. | |
| AS-1669058 | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide; AS 1535907; AS 1669058; AS 1907417; GPR119 agonists - Astellas Pharma; 1395553-32-8(OXLATE). Grade: 98%. CAS No. 1395553-31-7. Molecular formula: C18H15BrF2N4O. Mole weight: 421.24. | |
| AS-1669058 oxalate | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: AS-1669058 oxalate; AS 1669058 oxalate; AS1669058 oxalate; 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide oxalate. Grade: 98%. CAS No. 1395553-32-8. Molecular formula: C18H15BrF2N4O.C2H2O4. Mole weight: 511.28. | |
| AS1810722 | AS1810722 shows potent STAT6 inhibition and a good CYP3A4 inhibition profile. Synonyms: AS-1810722. Grade: 98%. CAS No. 909561-15-5. Molecular formula: C25H25F2N7O. Mole weight: 477.51. | |
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Synonyms: AS1842856; AS-1842856; AS 1842856. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grade: 98%. CAS No. 836620-48-5. Molecular formula: C18H22FN3O3. Mole weight: 347.38. | |
| AS 1892802 | AS 1892802 has been found to be an ATP-competitive ROCK inhibitor and could show analgesic activities at some extent. Synonyms: AS 1892802; AS1892802; AS-1892802; N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea. Grade: ≥99% by HPLC. CAS No. 928320-12-1. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| AS 19 | AS 19 has been found to be a potent SR-7 agonist and could probably enhance memory consolidation. Synonyms: AS 19; AS-19; AS19; (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin. Grade: ≥98% by HPLC. CAS No. 1000578-26-6. Molecular formula: C18H25N3. Mole weight: 283.41. | |
| AS1940477 | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
| AS 1949490 | AS1949490 has been found to be a selective SHIP2 phosphatase inhibitor and show antidiabetic activities. Synonyms: AS1949490; AS-1949490; AS 1949490; 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide. Grade: ≥99% by HPLC. CAS No. 1203680-76-5. Molecular formula: C20H18ClNO2S. Mole weight: 371.88. | |
| AS 2034178 | AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes. Synonyms: AS 2034178; AS2034178; AS-2034178; 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid. Grade: ≥98% by HPLC. CAS No. 1030846-42-4. Molecular formula: C27H29FN2O3. Mole weight: 448.53. | |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
| AS-252424 | AS-252424 is a novel, potent PI3Kγ inhibitor (IC50 of 30 nM) with a 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β. Synonyms: AS252424; AS 252424; AS-252424. Grade: >98%. CAS No. 900515-16-4. Molecular formula: C14H8FNO4S. Mole weight: 305.28. | |
| AS 252424 bispotassium salt | AS 252424 bispotassium salt is the potassium salt form of AS 252424, which is a potent and selective PI3K p110γ inhibitor. Synonyms: AS 252424 bispotassium salt; AS252424 bispotassium salt; AS-252424 bispotassium salt; dipotassium (5Z)-5-[[5-(4-fluoro-2-oxidophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazol-2-olate. Grade: 99%. Molecular formula: C14H6FNO4S.K2. Mole weight: 381.46. | |
| AS2717638 | AS2717638 is a potent, selective, orally active and brain-penetrant lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. It significantly improves allodynia induced by PGE2, PGF2α and AMPA. Synonyms: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(piperidin-1-ylcarbonyl)isoquinolin-1(2H)-one; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone. Grade: ≥95%. CAS No. 2148339-28-8. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| AS2863619 | AS2863619 is an orally active cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.61 nM and 4.277 nM, respectively. In vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. Synonyms: 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine dihydrochloride; 4-(1-(2-Methyl-1H-benzo[d]imidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine dihydrochloride. CAS No. 2241300-51-4. Molecular formula: C16H14Cl2N8O. Mole weight: 405.24. | |
| AS2863619 free base | STAT5 activation enhanced by AS2863619 free base inhibits CDK8/19, which consequently activates the Foxp3 gene. Synonyms: AS2863619 (free base). Grade: 98%. CAS No. 2241300-50-3. Molecular formula: C16H12N8O. Mole weight: 332.32. | |
| AS-35 | AS-35 is used as an antiallergic drug. It controls allergic diseases by inhibiting eosinophil activation. Uses: As-35 is used as an antiallergic drug. Synonyms: AS 35; AS35; AS-35; 3-(1H-Tetrazol-5-yl)-9-[[[2-propyl-3-hydroxy-4-(methylcarbonyl)phenyl]oxy]methyl]-4H-pyrido[1,2-a]pyrimidin-4-one; AS35; 4H-Pyrido(1,2-a)pyrimidin-4-one, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-; 9-((4-Acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one. Grade: >98%. CAS No. 108427-72-1. Molecular formula: C21H20N6O4. Mole weight: 420.42. | |
| AS601245 | AS601245 is a JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. Synonyms: AS601245; AS-601245; AS 601245. Grade: >98%. CAS No. 345987-15-7. Molecular formula: C20H16N6S. Mole weight: 372.45. | |
| AS-601811 | AS-601811 is a 5-α reductase (type 1) inhibitor developed for the treatment of acne. Synonyms: 4,8-dimethyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-one; AS-601811; AS 601811; AS601811; UNII-LIV8A6AE5F. Grade: >98%. CAS No. 194979-95-8. Molecular formula: C15H17NO. Mole weight: 227.307. | |
| AS 602801 | AS 602801 is a novel, orally active inhibitor of JNK. It blocked T-lymphocyte proliferation and induced apoptosis. Synonyms: AS602801; AS-602801; AS 602801; PGL5001; PGL-5001; PGL 5001; Bentamapimod. Grade: >98%. CAS No. 848344-36-5. Molecular formula: C25H23N5O2S. Mole weight: 457.55. | |
| AS-604850 | AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. Synonyms: AS604850; AS 604850; AS-604850. PI3K gamma inhibitor; PI 3-Kgamma Inhibitor II; (5E)-5-[(2,2-Difluoro-1,3-benzodioxol-5-YL)methylene]-1,3-thiazolidine-2,4-dione. Grade: 98%. CAS No. 648449-76-7. Molecular formula: C11H5F2NO4S. Mole weight: 285.211. | |
| AS-605240 | AS605240 is a selective PI3Kgamma inhibitor, has been proved effective on several inflammatory diseases. Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis. Synonyms: AS 605240; AS605240; AS-605240. Grade: 0.98. CAS No. 648450-29-7. Molecular formula: C12H7N3O2S. Mole weight: 257.267. | |
| AS-605240 potassium salt | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grade: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
| AS 8351 | AS 8351 has been found to show the activity in inducing reprogramming of human fetal lung fibroblasts into functional cardiomyocytes. Synonyms: AS-8351; AS-8351; AS-8351; 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone. Grade: ≥98% by HPLC. CAS No. 796-42-9. Molecular formula: C17H13N3O2. Mole weight: 291.30. | |
| AS-85 | AS-85 is a potent inhibitor of ASH1L histone methyltransferase with an IC50 of 0.6 μM. AS-85 has anti-leukemic activity and strongly binds to the ASH1L SET domain, with a Kd of 0.78 μM. Synonyms: 3-Azetidinecarboxamide, N-[[3-[3-(aminothioxomethyl)phenyl]-1-[1-[(trifluoromethyl)sulfonyl]-4-piperidinyl]-1H-indol-6-yl]methyl]-. CAS No. 2323623-80-7. Molecular formula: C26H28F3N5O3S2. Mole weight: 579.66. | |
| AS-99 | AS-99 is a potent and selective ASH1L histone methyltransferase inhibitor (IC50 =?0.79?μM, Kd =?0.89?μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. Molecular formula: C27H31ClF3N5O3S2. Mole weight: 630.14. | |
| AS-99 free base | AS-99 is a potent and selective ASH1L histone methyltransferase inhibitor (IC50=?0.79?μM, Kd=?0.89?μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. CAS No. 2323623-93-2. Molecular formula: C27H30F3N5O3S2. Mole weight: 593.68. | |
| AS-99 TFA | AS-99 is a potent and selective ASH1L histone methyltransferase inhibitor (IC50=?0.79?μM, Kd=?0.89?μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. Synonyms: AS-99 (TFA); AS-99 TFA; HY-141429A; MS-31187; CS-0227299. Grade: ≥98%. Molecular formula: C29H31F6N5O5S2. Mole weight: 707.71. | |
| ASB14780 | ASB14780 is a potent and oral inhibitor of cytosolic phospholipase A2α (cPLA2α; IC50 = 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay) with anti-inflammatory property in ear edema and asthma models. ASB14780 has the potential for the treatment of nonalcoholic fatty liver diseases including fatty liver and hepatic fibrosis. ASB14780 significantly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA and TGFb1 in the liver, as well as the expression of monocyte/macrophage markers. Synonyms: ASB14780; ASB 14780; ASB-14780; 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol; 3-[1-(4-Phenoxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid, 2-amino-2-(hydroxymethyl)-1,3-propanediol. Grade: 99%. CAS No. 1069046-00-9. Molecular formula: C31H27NO3.C4H11NO3. Mole weight: 582.69. | |
| Asciminib | Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Uses: Tyrosine kinase inhibitors. Synonyms: ABL-001; ABL 001; ABL001; N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide. CAS No. 1492952-76-7. Molecular formula: C20H18ClF2N5O3. Mole weight: 449.843. | |
| Ascochlorin A | Ascochlorin A, a potent hDHODH inhibitor (KD = 3.29 μM), is used for the treatment of triple-negative breast cancer. Synonyms: Acremochlorin A. CAS No. 2550720-02-8. Molecular formula: C23H31ClO4. Mole weight: 406.94. | |
| Ascophyllum nodosum extract | Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Ascophyllum nodosum, Fucaceae. Synonyms: Fucoidan, ex ascophyllum nodosum; Ascophyllum nodosum, ext.; Stimax; Stimax Growth. CAS No. 84775-78-0. | |
| Ascorbic acid 3-sulfate | An impurity of Ascorbic acid. Ascorbic acid is a water-soluble vitamin essential for human health. It is found in citrus fruits, berries, and vegetables and is widely used to prevent and treat scurvy, a disease caused by Vitamin C deficiency. Vitamin C plays a crucial role in tissue repair, collagen formation, and the production of certain neurotransmitters. It also functions as an antioxidant and supports immune system function. Synonyms: Vitamin C 3-sulfate; L-Ascorbic Acid 3-Sulfate; L-Ascorbic acid, 3-(hydrogen sulfate); (R)-2-((S)-1,2-Dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-yl hydrogen sulfate. CAS No. 22430-27-9. Molecular formula: C6H8O9S. Mole weight: 256.19. | |
| Ascorbic acid EP Impurity D | An impurity of Ascorbic acid. Ascorbic acid is a water-soluble vitamin essential for human health. It is found in citrus fruits, berries, and vegetables and is widely used to prevent and treat scurvy, a disease caused by Vitamin C deficiency. Vitamin C plays a crucial role in tissue repair, collagen formation, and the production of certain neurotransmitters. It also functions as an antioxidant and supports immune system function. Synonyms: Methyl L-xylo-hex-2-ulosonate; Methyl L-sorbosonate; L-xylo-2-Hexulosonic acid, methyl ester; L-xylo-Hexulosonic acid, methyl ester; Gulonic acid, 2-keto-, methyl ester, L-; Methyl L-xylo-2-hexulosonate; 2-keto-L-Gulonic acid methyl ester; Methyl 2-keto-L-gulonate; Methyl L-xylo-hexulosonate; NSC 163924; Ascorbic acid Impurity D. Grade: ≥95%. CAS No. 3031-98-9. Molecular formula: C7H12O7. Mole weight: 208.17. | |
| Ascorbyl Palmitate | Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C. Ascorbyl palmitate can be widely used in whitening, freckle removal, anti-aging, wrinkle removal, antioxidant and other functional cosmetics. It is relatively safe, can be used with confidence, generally does not affect pregnant women, no acne-causing. Ascorbyl palmitate is a potent antioxidant and non-acidic, stable form of vitamin C. It has all the physiological activities of vitamin C, which can play an anti-inflammatory role, reduce melanin production, promote immunoglobulin synthesis, prevent and treat pigmentation caused by trauma, sunburn, acne, etc., whiten skin, maintain skin elasticity, reduce wrinkles, improve skin roughness, pallor, slack and other phenomena, delay skin natural aging and photoaging. It is a highly effective antioxidant and oxygen-free radical scavenger with a neutral pH. Synonyms: L-Ascorbic Acid, 6-hexadecanoate; L-Ascorbic Acid, 6-Palmitate; Palmitic Acid, 6-Ester with Ascorbic Acid; 6-Hexadecanoyl-L-ascorbic Acid; 6-Monopalmitoyl-L-ascorbate; 6-O-Palmitoyl-L-ascorbic Acid; 6-O-Palmitoylascorbic Acid; 6-Palmitate-L-ascorbic Acid; 6-Palmitoylascorbic Acid; Ascorbic Acid 6-Palmitate; Ascorbic Acid Palmitate; Ascorbyl 6-Palmitate; L-Ascorbyl Palmitate; NSC 402451; Ondascora. Grade: >98%. CAS No. 137-66-6. Molecular formula: C22H38O7. Mole weight: 414.53. | |
| Ascorbyl Propyl Hyaluronate (VAHA) | Ascorbyl Propyl Hyaluronate (VAHA) is a stable derivative of Vitamin C combined with hyaluronic acid, designed to offer the benefits of both ingredients. It provides deep hydration, brightens the skin, reduces the appearance of wrinkles, and protects against free radicals. VAHA is valued for its multifunctionality in skincare, including its antioxidant properties, promotion of collagen synthesis, and support for skin repair and anti-inflammatory effects. It also has the effect of removing acne and freckles. Synonyms: Hyaluronic acid, ester with 3-O-(3-hydroxypropyl)-L-ascorbic acid. Grade: ≥95%. CAS No. 1800464-57-6. | |
| Ascorbyl tetraisopalmitate | Ascorbyl tetraisopalmitate is a newly developed esterified derivative of Vitamin C with the highest stability of all Vitamin C derivatives. It can be absorbed transdermally and then effectively converted into vitamin C. It can inhibit the synthesis of melanin and remove the melanin present. Accordingly, it activates the collagen tissue directly at the base of the skin, accelerates collagen production, and prevents skin aging. It is a functional whitening agent that has anti-inflammatory, antioxidant and acne-removing effects and can promote collagen synthesis, reduce skin wrinkles, and prevent skin aging. Uses: Cosmetic raw materials. Synonyms: L-Ascorbic acid, 2,3,5,6-tetrakis(2-hexyldecanoate); Ascorbate Tetraisopalmitate; VC-IP; L-Ascorbic acid, tetrakis(2-hexyldecanoate); Ascorbyl tetra-2-hexyldecanoate; BV-OSC; Nikkol VC-IP; Vitamin C tetra-isopalmitate; Tetrahexyldecyl ascorbate; Esterified VC; Fat-soluble vitamin C. Grade: 98%. CAS No. 183476-82-6. Molecular formula: C70H128O10. Mole weight: 1129.79. | |
| Ascr#18 | Ascr#18, an ascaroside and a hormone of nematodes, is expressed during nematode development. It increases resistance in Arabidopsis, tomato, potato and barley to viral, bacterial, oomycete, fungal and nematode infections. Synonyms: Undecanoic acid, 10-[(3,6-dideoxy-α-L-arabino-hexopyranosyl)oxy]-, (10R)-; (10R)-10-[(3,6-Dideoxy-α-L-arabino-hexopyranosyl)oxy]undecanoic acid. Grade: ≥98%. CAS No. 1355681-10-5. Molecular formula: C17H32O6. Mole weight: 332.43. | |
| Aselizumab | Aselizumab. Synonyms: Aselizumab; Aselizumab [inn]; Bnp 001; Hudreg-55; Immunoglobulin G4, anti-(L-selectin) (human-mouse monoclonal hudreg-55 heavy chain), disulfide with human-mouse monoclonal hudreg-55 light chain, dimer. Grade: 95%. CAS No. 395639-53-9. | |
| Asenapine | Asenapine is an atypical antipsychotic multireceptor neuroleptic drug by combining serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Uses: Antipsychotic. Synonyms: Org 5222; HSDB 8061; Org5222; HSDB8061; Org-5222; HSDB-8061; (3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7] oxepino[4,5-c]pyrrole. Grade: ≥98%. CAS No. 65576-45-6. Molecular formula: C17H16ClNO. Mole weight: 285.7724. | |
| Asenapine hydrochloride | Asenapine hydrochloride, also called Org 5222 and HSDB 8061, shows high affinity for numerous receptors including 5-HT receptor and adrenergic receptor. (pKi: 5-HT1A= 8.6, 5-HT1B= 8.4, 5-HT2A= 10.2, 5-HT2B= 9.8, 5-HT2C= 10.5, 5-HT5A= 8.8, 5-HT6= 9.5, and. Synonyms: Asenapine (hydrochloride); 1412458-61-7; DTXSID10678678; CS-1053; HY-16567; W-6082; CS 1053; HY 16567; W 6082; CS1053; HY16567; W6082; (3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole--hydrogen chloride (1/1). CAS No. 1412458-61-7. Molecular formula: C17H17Cl2NO. Mole weight: 322.23. | |
| Asenapine maleate | Asenapine Maleate is a 5-HT receptor antagonist used for the treatment of acute schizophrenia and bipolar mania. It is a second-generation (atypical) antipsychotic agent. Synonyms: (3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-Butenedioate; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole; Org 5222. Grade: >98%. CAS No. 85650-56-2. Molecular formula: C21H20ClNO5. Mole weight: 401.84. | |
| Asenapine N-b-D-glucuronide | Asenapine N-b-D-glucuronide is a metabolite derived from the antipsychotic compound asenapine with utilization encompassing compound metabolism analysis, drug-drug interaction assessment and pharmacokinetic investigations surrounding asenapine. Molecular formula: C23H24ClNO7. Mole weight: 461.89. | |
| Asenapine-N-oxide | A metabolite of Asenapine. Synonyms: (3aR-trans)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole 2-Oxide. Grade: > 95%. CAS No. 128949-51-9. Molecular formula: C17H16ClNO2. Mole weight: 301.78. | |
| Asenapine O-sulfate | A metabolite of Asenapine. Synonyms: Asenapine 11-Hydroxysulfate. Grade: > 95%. CAS No. 1399103-21-9. Molecular formula: C17H16ClNO5S. Mole weight: 381.84. | |
| Asialo, galactosylated, fucosylated, biantennary (G1F) | Asialo, galactosylated, fucosylated, biantennary (G1F) - a formidable glycan structure with therapeutic potential, capable of wrangling a plethora of diseases, ranging from the insidious grip of cancer to the fiery inflammation. Studies indicate that G1F galvanizes antibody-dependent cellular cytotoxicity (ADCC), augments pharmacokinetics and reinforces the stability of recombinant proteins. It is a versatile tool in glycoengineering, which can be exploited to optimize the therapeutic properties of therapeutic proteins. Molecular formula: C62H104N4O45. Mole weight: 1625.49. | |
| Asialo-GM1-pentasaccharide-APD-HSA | Asialo-GM1-pentasaccharide-APD-HSA is an innovative biomedical compound, unveiling its paramount significance in the realm of research for specific ailments and conditions. Engineered meticulously to intricately engage Asialo-GM1 receptors with profound efficacy, this prodigious compound steadfastly facilitates compound conveyance. Synonyms: Asialo GM1 oligosaccharide. | |
| Asimadoline | Asimadoline is a κ opioid receptor agonist with less brain-penetrant ability. Asimadoline is the potential treatment of irritable bowel syndrome. Synonyms: N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide. CAS No. 153205-46-0. Molecular formula: C27H30N2O2. Mole weight: 414.549. | |
| ASK120067 | ASK120067, a third generation EGFR-TKI for non-small cell lung cancer (NSCLC) research, is a potent and orally active EGFRT790M inhibitor (IC50 = 0.3 nM) with selectivity over EGFRWT (IC50 = 6.0 nM). Synonyms: 2-Propenamide, N-[5-[[5-chloro-4-(2-naphthalenylamino)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-; N-(5-{[5-Chloro-4-(2-naphthylamino)-2-pyrimidinyl]amino}-2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxyphenyl)acrylamide. Grade: ≥98%. CAS No. 1934259-00-3. Molecular formula: C29H32ClN7O2. Mole weight: 546.06. | |
| ASK1-IN-1 | ASK1-IN-1 is a CNS-penetrant ASK1 inhibitor, with good potency (cell IC50 = 138 nM; Biochemical IC50 = 21 nM). Grade: 99%. CAS No. 2411382-24-4. Molecular formula: C23H21N7O. Mole weight: 405.41. | |
| ASK1-IN-2 | ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 32.8 nM. It can potentially be used as a therapeutic strategy for ulcerative colitis. Synonyms: ASK1-IN-2; 2541792-70-3; EX-A7533; AKOS040759790; MS-25802; HY-131969; CS-0145639. Grade: 98%. CAS No. 2541792-70-3. Molecular formula: C19H17FN6O. Mole weight: 364.38. | |
| ASM-024 | ASM-024 is a small synthetic compound and a potent nicotinic receptor agonist developed for airway inflammatory diseases as the primary target therapeutic indication. It acts as a dual anti-inflammatory and bronchodilating agent in preclinical models. Synonyms: 1H-1,4-Diazepinium, 1,1-diethylhexahydro-4-phenyl; di-ethyl-4-phenylhomopiperazinium. Grade: >98.0%. CAS No. 1609534-88-4. Molecular formula: C15H25N2. Mole weight: 233.37. | |
| ASN-002 | ASN-002 (Gusacitinib) is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with an IC50 value of 5-46 nM. It has anti-cancer activity. Synonyms: Gusacitinib. Grade: ≥98% by HPLC. CAS No. 1425381-60-7. Molecular formula: C24H28N8O2. Mole weight: 460.5. | |
| ASN03576800 | ASN03576800 is an inhibitor of the VP40 matrix protein. Synonyms: ASN03576800; 957513-35-8; 2-[2-(1,3-benzodioxol-5-ylamino)-2-oxoethyl]sulfinylacetic acid; 2-[2-(1,3-Benzodioxol-5-ylamino) -2-oxoethyl]sulfinylacetic acid; 2-{[(2H-1,3-benzodioxol-5-yl)carbamoyl]methanesulfinyl}acetic acid; Oprea1_545175; Oprea1_630695; -2-oxoethyl]sulfinylacetic acid; DTXSID801167190; GLXC-03389; BCP09132; EX-A4721; AKOS000736686; 2-[2-(1,3-Benzodioxol-5-ylamino); AC-36597; AS-16456; DA-61260; HY-113761; CS-0063256; SR-01000327329; SR-01000327329-1; 2-[[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfinyl]acetic acid; {[(2H-1,3-BENZODIOXOL-5-YL)CARBAMOYL]METHANESULFINYL}ACETIC ACID; 2-((2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl)sulfinyl)acetic acid; 2-[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl]sulfinylacetic acid; (Benzo[1,3]dioxol-5-ylcarbamoylmethanesulfinyl)-acetic acid. Grade: >98%. CAS No. 957513-35-8. Molecular formula: C10H6N8. Mole weight: 238.21. | |
| Asn(Acm)-Desmopressin | Asn(Acm)-Desmopressin is an impurity of Desmopressin, which is a synthetic octapeptide and an analog of the human hormone arginine vasopressin with antidiuretic and coagulant activities. Synonyms: Deamino-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl(Acm)-L-cysteinyl-L-prolyl-D-arginyl-glycinamide (1->6)-disulfide; deamino-Cys-Tyr-Phe-Gln-Asn(Acm)-Cys-Pro-D-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Mpr-Tyr-Phe-Gln-Asn(Acm)-Cys-Pro-D-Arg-Gly-NH2 (Disulfide Bridge Mpr1-Cys6); [Asn(Acm)]5-Desmopressin; Asn5(Acm)-Desmopressin; N4.5-[(Acetylamino)methyl]desmopressin; Desmopressin EP Impurity F. Grade: ≥95%. Molecular formula: C49H69N15O13S2. Mole weight: 1140.30. | |
| a-Solanine | a-Solanine, an organic compound existing naturally in potatoes and tomatoes, has garnered attention in the field of biomedicine. Its viability in combating specific forms of cancer has been extensively explored. Extensive research illustrates that a-Solanine showcases exceptional anticancer traits by restraining tumor proliferation and stimulating programmed cell death in malignant cells. Synonyms: (3β)-Solanid-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside; α-Solanine; α-Solanin. CAS No. 20562-02-1. Molecular formula: C45H73NO15. Mole weight: 868.06. | |
| Asoprisnil | Asoprisnil is a selective progesterone receptor (PR) modulator developed for the treatment of progesterone sensitive myomata. Synonyms: J867; J-867; J 867; Asoprisnil; Asoprisnilum. 11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one; (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one. Grade: 98%. CAS No. 199396-76-4. Molecular formula: C28H35NO4. Mole weight: 449.58. | |
| Asoprisnil ecamate | Asoprisnil ecamate is a selective progesterone receptor modulator potentially for the treatment of endometriosis. Synonyms: Benzaldehyde, 4-[(11β,17β)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]-, 1-[O-[(ethylamino)carbonyl]oxime], [C(E)]-; J 956; (E)-4-((8S,11R,13S,14S,17S)-17-methoxy-17-(methoxymethyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)benzaldehyde O-ethylcarbamoyl oxime; (11β,17β)-11-{4-[(E)-{[(Ethylcarbamoyl)oxy]imino}methyl]phenyl}-17-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one. Grade: ≥95%. CAS No. 222732-94-7. Molecular formula: C31H40N2O5. Mole weight: 520.67. | |
| Asoxime Chloride | Cholinesterase reactivator. A potential antidote for organophosphate poisoning. Synonyms: 1[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]pyridinium Dichloride. Grade: > 95%. CAS No. 34433-31-3. Molecular formula: C14H16N4O3.2 Cl. Mole weight: 359.21. | |
| Asoxime-d4 Chloride | Asoxime-d4 Chloride is a labelled Asoxime Chloride. Asoxime Chloride is a cholinesterase reactivator used in the treatment of organophosphate poisoning. Synonyms: 1[[[4-(Aminocarbonyl)pyridinio-d4]methoxy]methyl]-2-[(hydroxyimino)methyl]pyridinium Dichloride; HI 6-d4 Chloride; HJ 6-d4. Grade: > 95%. Molecular formula: C14H12N4O3D4·2Cl. Mole weight: 363.23. | |
| ASP1126 | ASP1126 is a selective and orally active agonist of sphingosine-1-phosphate (S1P), with EC50s of 7.12 and 517 nM for hS1P1 and hS1P3, respectively. ASP1126 can reduce the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood, and has the potential to be used in clinical transplantation to improve safety profile. Synonyms: 1-[(7-{[4-(2,2,2-Trifluoroethoxy)-3-(trifluoromethyl)benzyl]oxy}-2H-chromen-3-yl)methyl]-4-piperidinecarboxylic acid hydrochloride (1:1); 4-Piperidinecarboxylic acid, 1-[[7-[[4-(2,2,2-trifluoroethoxy)-3-(trifluoromethyl)phenyl]methoxy]-2H-1-benzopyran-3-yl]methyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 1228580-11-7. Molecular formula: C26H26ClF6NO5. Mole weight: 581.93. | |
| ASP-1645 | ASP-1645 is a novel P2Y12 receptor antagonist using as an antiplatelet agent. Uses: An antiplatelet agent. Synonyms: ASP-1645; ASP 1645; ASP1645; UNII-M5SN288R8N; (2S)-2-((7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinyl)oxy)-Propanoic acid. Grade: 98%. CAS No. 1347392-70-4. Molecular formula: C23H29FN2O4. Mole weight: 416.49. | |
| ASP 2535 | ASP-2535 has been found to be a GlyT1 inhibitor and brain penetrant. Synonyms: ASP-2535; ASP 2535; ASP2535; 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole. Grade: ≥98% by HPLC. CAS No. 374886-51-8. Molecular formula: C22H18N6O. Mole weight: 382.42. | |
| Asp-26-Calcitonin | Asp-26-Calcitonin is an impurity of Calcitonin salmon, which is a calcium regulating hormone used to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond between Cys1 and Cys7); L-cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-α-aspartyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide. Molecular formula: C145H239N43O49S2. Mole weight: 3432.88. | |
| ASP 2905 | ASP 2905 is a potent and selective potassium channel KCNH3 (Kv12.2) inhibitor with an IC50 of 9.0 nM. KCNH3 is concentrated in the forebrain, and its overexpression in mice leads to cognitive deficits. ASP 2905 has been identified as a candidate for the treatment of attention deficit/hyperactivity disorder. Synonyms: N2-(4-Fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine. Grade: 98%. CAS No. 792184-90-8. Molecular formula: C20H17FN8. Mole weight: 388.40. | |
| ASP-3026 | ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. In an anchorage independent in vitro cell growth assay, ASP3026 inhibited the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3 and that of 3T3 cells expressing EML4-ALK variant 1, 2 and 3. Synonyms: ASP3026; ASP 3026. Grade: 0.98. CAS No. 1097917-15-1. Molecular formula: C29H40N8O3S. Mole weight: 580.74. | |
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