BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AR-L 100 BS | AR-L 100 BS is a bio-active chemical with cardiovascular effects originated by oehringer Ingelheim Pharma KG. But no development was reported for Ischaemic heart disorders till now. Uses: Ischaemic heart disorders. Synonyms: AR-L 100 BS; AR-L-100BS; AR-L100 BS; BRN 0842454; 2-(4-Methoxy-2-(2-(methylsulfinyl)ethoxy)phenyl)-1H-imidazo(4,5-b)pyridine. Grade: 98%. CAS No. 77303-18-5. Molecular formula: C16H17N3O3S. Mole weight: 331.39. |  |
| ARL 17477 dihydrochloride | The hydrochloride salt form of ARL 17477, which has been found to be a nitric oxide synthase (NOS) inhibitor and could induce apoptosis/cell death in leukemia cells. Synonyms: 2-Thiophenecarboximidamide, N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-, hydrochloride (1:2); 2-Thiophenecarboximidamide, N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-, dihydrochloride; ARL17477 dihydrochloride; ARL-17477 dihydrochloride; N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride. Grade: ≥98% by HPLC. CAS No. 866914-87-6. Molecular formula: C20H20ClN3S.2HCl. Mole weight: 442.83. | |
| ARL 67156 | ARL 67156 is an ecto-ATPase inhibitor/ATP analog. Synonyms: ARL 67157; FPL 67156. CAS No. 160928-38-1. Molecular formula: C15H24Br2N5O12P3. Mole weight: 719.11. | |
| ARL 67156 trisodium salt | The sodium salt form of ARL 67156, which has been found to be an ecto-ATPase inhibitor. Synonyms: ARL 67156; ARL-67156; ARL67156; 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt. Grade: ≥98% by HPLC. CAS No. 1021868-83-6. Molecular formula: C15H21Br2N5O12P3.3Na. Mole weight: 785.06. | |
| AR-M 1000390 hydrochloride | AR-M 1000390 hydrochloride is an agonist of δ-selective opioid receptor with an analgesic effect. AR-M 1000390 hydrochloride can reduce CFA-induced hyperalgesia. Uses: Arm-390hcl is an agonist of δ-selective opioid receptor with an analgesic effect. Synonyms: ARM-390 HCl; ARM 390 HCl; ARM390 HCl; ARM 1000390 hydrochloride; ARM1000390 hydrochloride; N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Monohydrochloride. Grade: ≥97% by HPLC. CAS No. 209808-47-9. Molecular formula: C23H29ClN2O. Mole weight: 384.94. | |
| ARM1 hydrobromide | ARM1 hydrobromide is a novel Leukotriene A4 hydrolase/aminopeptidase (LTA4H) inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro. Synonyms: ARM1 hydrobromide; ARM 1 hydrobromide; ARM-1 hydrobromide; 4-(4-benzylphenyl)-1,3-thiazol-2-amine hydrobromide. Grade: 99%. CAS No. 1049743-03-4. Molecular formula: C16H14N2S.HBr. Mole weight: 347.27. | |
| Armeniaspirol A | Armeniaspirol A is a novel anti-Helicobacter pylori agent isolated from Streptomyces armeniacus that has been previously identified as an antibacterial agent against Gram-positive pathogens. Synonyms: Armeniaspirole A. CAS No. 1206881-47-1. Molecular formula: C18H19Cl2NO4. Mole weight: 384.25. | |
| Armeniaspirol B | Armeniaspirol B is a novel anti-Helicobacter pylori agent isolated from Streptomyces armeniacus that has been previously identified as an antibacterial agent against Gram-positive pathogens. Synonyms: Armeniaspirole B. CAS No. 1206881-48-2. Molecular formula: C18H19Cl2NO4. Mole weight: 384.25. | |
| Armeniaspirol C | Armeniaspirol C is a novel anti-Helicobacter pylori agent isolated from Streptomyces armeniacus that has been previously identified as an antibacterial agent against Gram-positive pathogens. Synonyms: Armeniaspirole C. CAS No. 1206881-49-3. Molecular formula: C19H21Cl2NO4. Mole weight: 398.28. | |
| ARN 14686 | ARN14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. ARN14686 can be used to detect NAAA by using click chemistry in cell lysates or intact cells, which binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells. The IC50s for human is 6 and the IC50s for rat recombinant enzymes is 13 nM. Synonyms: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate. Grade: ≥98% by HPLC. CAS No. 1628345-10-7. Molecular formula: C15H24N2O3. Mole weight: 280.36. | |
| ARN14974 | ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. Synonyms: Acid Ceramidase Inhibitor 17a; ARN-14974; ARN 14974; Acid Ceramidase Inhibitor 17a. Grade: ≥95%. CAS No. 1644158-57-5. Molecular formula: C24H21FN2O3. Mole weight: 404.4. | |
| ARN14988 | ARN14988 can normalize ceramide levels and concomitantly sensitize proliferative melanoma cells to the cytotoxic actions of various antitumoral agents. ARN14988 is a potent inhibitor of acid ceramidase with IC50 of 12.8 nM for the human enzyme. ARN14988 also reduces growth of A375 with EC50s of 41.8 μM and G361 with EC50s of 67.7 μM. Synonyms: ARN 14988; ARN-14988. Grade: ≥98%. CAS No. 1502027-70-4. Molecular formula: C16H24ClN3O5. Mole weight: 373.83. | |
| ARN19702 | ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 of 230 nM for human NAAA. Synonyms: ARN-19702; ARN 19702. Grade: 98% by HPLC. CAS No. 1971937-18-4. Molecular formula: C21H22FN3O3S2. Mole weight: 447.6. | |
| ARN19874 | ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 μM. ARN19874 is the first selective, cell-active inhibitor of NAPE-PLD. It is significantly less potent on the Q320A mutant, and it can cause a substantial accumulation of non-metabolized NAPE species iuman HEK-293 cells at 50 uM. Uses: Enzyme inhibitors. Synonyms: 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide. Grade: ≥98%. CAS No. 2190502-57-7. Molecular formula: C19H14N4O4S. Mole weight: 394.41. | |
| ARN-21934 | ARN-21934 is a potent, highly selective and blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. Compared with anticancer agent Etoposide (IC50 = 120 μM), ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM. It is a promising anticancer lead compound with good pharmacokinetic profile in vivo. Synonyms: 4,6-Quinazolinediamine, N4-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro-2-(4-pyridinyl)-; N4-[4-(Dimethylamino)phenyl]-2-(4-pyridinyl)-5,6,7,8-tetrahydro-4,6-quinazolinediamine. Grade: ≥98%. CAS No. 2230854-93-8. Molecular formula: C21H24N6. Mole weight: 360.46. | |
| ARN24139 | ARN24139 is an orally active topoisomerase II poison with an IC50 of 7.3 μM. Synonyms: 6-Hydroxy-4-oxo-1,3-diphenyl-2-thioxo-N-(3-(trifluoromethoxy)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide. Grade: 99%. CAS No. 2699768-78-8. Molecular formula: C24H16F3N3O4S. Mole weight: 499.46. | |
| ARN 272 | ARN 272 has been found to be a FLAT inhibitor and could show analgesic activities in CB1-mediated nociceptive and inflammatory pain. Synonyms: ARN272; ARN-272; ARN 272; 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide. Grade: ≥98% by HPLC. CAS No. 488793-85-7. Molecular formula: C27H20N4O2. Mole weight: 432.47. | |
| ARN2966 | ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: 2-(pyridin-2-ylmethylamino)phenol; 2-PMAP; ARN2966; ARN-2966; Phenol, 2-[(2-pyridinylmethyl)amino]-; 102212-26-0; AGN-PC-0031SD; GTPL7530; 2-(2-Pyridylmethylamino)phenol; SCHEMBL10886688; AOB1080; SYN5152; 2-(pyridin-2-ylmethylamino)phenol; 3970AH; ZINC34411048; AKOS022987680; CS-3335; HY-18292; ARN-2966; CS 3335; HY 18292; ARN 2966; CS3335; HY18292; ARN2966. Grade: > 98%. CAS No. 102212-26-0. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
| ARN-3236 | ARN-3236 is an orally available and selective inhibitor of salt-inducible kinase 2 (SIK2). Study shows that ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. Synonyms: 3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine; 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine. CAS No. 1613710-01-2. Molecular formula: C19H16N2O2S. Mole weight: 336.41. | |
| ARN-5187 | ARN-5187, a piperazin derivative, has been found to be a REV-ERBβ inhibitor that could induce apoptotic in cancer cells and probably be more effective in breast cancer cells. Synonyms: ARN5187; ARN-5187; ARN 5187; 4-(((1-(2-fluorophenyl)cyclopentyl)amino)methyl)-2-((4-methylpiperazin-1-yl)methyl)phenol hydrochloride. Grade: 98%. CAS No. 1700693-96-4. Molecular formula: C24H33ClFN3O. Mole weight: 434.00. | |
| ARN726 | ARN726 is a systemically active and orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 value of 27 nM for human and 63 nM for rat NAAA. The selectivity for NAAA is better than fatty acid amide hydrolase (FAAH) with IC50s of 100 uM. It is also selective over acid cermidase with IC5Os of 12.5 uM. ARN726 can decrease lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. Synonyms: ARN-0726; ARN 0726. Grade: ≥95%. CAS No. 1628343-77-0. Molecular formula: C14H24N2O3. Mole weight: 268.35. | |
| Aroplatin | Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. The liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile. CAS No. 114488-24-3. Molecular formula: C26H52N2O4Pt. Mole weight: 651.79. | |
| Arotinolol | Arotinolol is a medication used primarily for the treatment of hypertension and certain types of arrhythmias. Arotinolol is a non-selective beta-adrenergic receptor antagonist (beta-blocker) that blocks both beta-1 and beta-2 receptors. This action reduces the effects of adrenaline and noradrenaline, leading to a decrease in heart rate and blood pressure. In addition to its beta-blocking properties, arotinolol also exhibits alpha-1 adrenergic receptor antagonism. This action leads to vasodilation and further reduction in blood pressure. Arotinolol is used to treat high blood pressure, helping to prevent complications such as stroke, heart attack, and kidney problems. It can be used to manage certain types of cardiac arrhythmias (irregular heartbeats). Arotinolol may be used to alleviate symptoms of angina, a condition characterized by chest pain due to reduced blood flow to the heart. Synonyms: 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-; 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (±)-; 5-[2-[[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide; (±)-Arotinolol; 2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole; NSC 317940. Grade: ≥95%. CAS No. 68377-92-4. Molecular formula: C15H21N3O2S3. Mole weight: 371.54. | |
| Arotinolol hydrochloride | Arotinolol hydrochloride. Synonyms: 5-[2-[(2S)-3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide; hydrochloride; UNII-FX47K0HTP6; FX47K0HTP6; 101540-26-5; SCHEMBL348621. Grade: 95%. CAS No. 101540-26-5. Molecular formula: C15H21N3O2S3?ClH. Mole weight: 408.009. | |
| ARP 100 | ARP 100 has been found to be a selective inhibitor of MMP-2 and could show anti-invasive properties in HT1080 fibrosarcoma cells at some extent. Synonyms: ARP100; ARP-100; ARP 100; 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide. Grade: ≥98% by HPLC. CAS No. 704888-90-4. Molecular formula: C17H20N2O5S. Mole weight: 364.42. | |
| ARP 101 | ARP 101 is a Selective MMP-2 inhibitor with IC50 value of 0.81 nM. It displays nearly 600-fold selectivity over MMP-1 (IC50 value 486 nM). ARP 101 has diverse physiological roles including wound healing, cancer metastasis, angiogenesis and so on. Synonyms: ARP-101; ARP 101; ARP101; (2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide. Grade: 98%. CAS No. 849773-63-3. Molecular formula: C20H26N2O5S. Mole weight: 406.50. | |
| Arphamenine A hemisulfate | Arphamenine A hemisulfate is the salt of Arphamenine A, which is an enzyme inhibitor produced by Chromobacteriuin violaceum HMG361-CF4. It can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and IMC cancer. Synonyms: Arphamenine A sulfate; Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-, (αR)-, sulfate (2:1); Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-, sulfate, [S-(R*,S*)]-; (2R,5S)-5-Amino-2-benzyl-8-[(diaminomethylene)amino]-4-oxooctanoic acid sulfate (2:1). Grade: >98%. CAS No. 144110-37-2. Molecular formula: C16H24N4O3.1/2H2O4S. Mole weight: 369.43. | |
| Arphamenine A hydrochloride | Arphamenine A hydrochloride is the salt of Arphamenine A, which is an enzyme inhibitor produced by Chromobacteriuin violaceum HMG361-CF4. It can inhibit the activity of aminopeptidase B, and can inhibit sarcoma 180 and IMC cancer. Synonyms: Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-, monohydrochloride, [S-(R*,S*)]-; Arphamenine A monohydrochloride; (2R,5S)-5-Amino-2-benzyl-8-[(diaminomethylene)amino]-4-oxooctanoic acid hydrochloride (1:1); Benzenepropanoic acid, α-[(3S)-3-amino-6-[(diaminomethylene)amino]-2-oxohexyl]-, (αR)-, hydrochloride (1:1). Grade: ≥95%. CAS No. 85713-14-0. Molecular formula: C16H24N4O3.HCl. Mole weight: 356.85. | |
| Arphamenine B | Arphamenine B is a specific inhibitor of aminopeptidase B, which is first isolated from bacteria. Arphamenine B shares the same properties as the aminopeptidase inhibitors bestatin and amastatin, both of which enhance the immune response. Synonyms: Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, (αR)-; (αR)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxybenzenepropanoic acid; Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, [S-(R*,S*)]-; Arphamenin B. Grade: 95%. CAS No. 103900-19-2. Molecular formula: C16H24N4O4. Mole weight: 336.39. | |
| Arphamenine B hemisulfate | Arphamenine B is a specific inhibitor of aminopeptidase B, which is first isolated from bacteria. Arphamenine B Hemisulfate is the hemisulfate form. Arphamenine B share the same property with aminopeptidase inhibitors bestatin and amastatin, they all enhance imune responses. Synonyms: Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, (αR)-, sulfate (2:1) (salt); Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, monohydrochloride, [S-(R*,S*)]-, sulfate (2:1) (salt); Arphamenine B sulfate; (αR)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxybenzenepropanoic acid, sulfate (2:1) (salt). Grade: ≥95%. CAS No. 144110-38-3. Molecular formula: C16H24N4O4·1/2H2SO4. Mole weight: 385.43. | |
| Arprinocid | Arprinocid is a coccidiostat used in veterinary medicine. Uses: Coccidiostats. Synonyms: Arpocox; Arprinocide; MK302; MK-302; MK 302; 9-(2-Chloro-6-fluorobenzyl)-9H-purin-6-amine; 6-Amino-9-(2-chloro-6-fluorobenzyl)purine. CAS No. 55779-18-5. Molecular formula: C12H9ClFN5. Mole weight: 277.69. | |
| ARQ 069 | ARQ 069 is an analogue of ARQ 523 and inhibits FGFR in an enantiospecific manner. ARQ 069 targets the unphosphorylated, inactive forms of FGFR1/FGFR2 kinases with IC50s of 0.84 and 1.23 μM, respectively. It inhibits FGFR1/FGFR2 autophosphorylation through a non-ATP competitive dependent mechanism with IC50s of 2.8 and 1.9 μM, respectively. Synonyms: Benzo[h]quinazolin-2-amine, 5,6-dihydro-6-phenyl-, (6S)-; 3RH. Grade: ≥95%. CAS No. 1314021-57-2. Molecular formula: C18H15N3. Mole weight: 273.33. | |
| ARQ-087 | ARQ-087, also known as Derazantinib, is an oral fibroblast growth factor receptor (FGFR) inhibitor with antitumor property. FGFR plays a role in the regulation of key cellular behaviors including proliferation, cell differentiation and so on. FGFR dysregulation is considered as a driver in multiple cancers. ARQ 087 binds to FGFR and effectively inhibits the activation of FGFR thus can suppress tumorigenesis and tumor growth. Synonyms: ARQ 087; ARQ087; ARQ-087; Derazantinib; (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine. Grade: ≥98%. CAS No. 1234356-69-4. Molecular formula: C29H29FN4O. Mole weight: 468.576. | |
| ARQ-092 | ARQ-092, also called as Miransertib, is an oral activie, potent and selective AKT inhibitor with IC50=5.0 nM against AKT1, 4.5 nM against AKT2 and 16 nM against AKT3. ARQ-092 inhibits the PI3K/AKT signaling pathway due to inhibition of the activity of AKT in a non-ATP competitive manner. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. Synonyms: 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ092; ARQ-092; ARQ 092; Miransertib. Grade: >98%. CAS No. 1313881-70-7. Molecular formula: C27H24N6. Mole weight: 432.53. | |
| ARQ 531 | ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity. ARQ 531 is a reversible non-covalent inhibitor of Bruton's Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases. In GCB-DLBCL cell lines (SUDHL-4 and DOHH-2), ARQ 531 potently suppressed expression of anti-apoptotic c-Myc and BCL6 oncoproteins in a dose-dependent fashion, and concomitantly induced apoptotic cleavage of PARP protein. Synonyms: ARQ-531. Grade: ≥98%. CAS No. 2095393-15-8. Molecular formula: C25H23ClN4O4. Mole weight: 478.93. | |
| ARQ-621 | ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Over-expression of Eg5 causes genomic instability and tumor formation in mice. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies. Synonyms: NSC-771644; N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluorobenzamide; (R)-N-(3-Aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide; Benzamide, N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-. Grade: ≥95%. CAS No. 1095253-39-6. Molecular formula: C28H24Cl2FN5O2. Mole weight: 552.43. | |
| ARQ 736 | ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. Synonyms: ARQ 736; ARQ736; ARQ-736. CAS No. 1228237-47-5. Molecular formula: C25H25N8Na2O8PS. Mole weight: 630.569. | |
| ARQ 736 disodium salt | This active molecular is a Proto oncogene protein b raf and Vascular endothelial growth factor A inhibitor originated by ArQule. ARQ 736 is effective in killing cancer cell lines that harboring at least one mutated b raf allele. The b raf protein is really a very important signaling molecule in the MAPK (mitogen activated protein kinase) signaling pathway and it relates to pathogenesis of variety kinds of cancer. In Mar 2014, Phase-I for Solid tumours (late-stage disease) was discontinued in USA. Uses: Solid tumours. Synonyms: ARQ 736 disodium salt; ARQ736 disodium salt; ARQ-736 disodium salt; sodium (R)-(3-(5-(2-((1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b]oxazol-6-yl)phenoxy)methyl phosphate; 1228237-47-5 free acid. Grade: 98%. CAS No. 1228237-57-7. Molecular formula: C25H25N8Na2O8PS. Mole weight: 674.54. | |
| AR-R 17779 hydrochloride | AR-R17779 has been found to be a selective alpha7 nicotinic agonist and could probably reduce blood pressure and serum lipid levels. Synonyms: AR-R 17779 hydrochloride; AR-R-17779 hydrochloride; AR-R17779 hydrochloride; ARR17779 hydrochloride; (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride. Grade: ≥98% by HPLC. CAS No. 178419-42-6. Molecular formula: C9H14N2O2.HCl. Mole weight: 218.68. | |
| ARRY-380 | ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. Synonyms: ARRY-380; ARRY 380; ARRY380. Grade: >98%. CAS No. 937265-83-3. Molecular formula: C29H27N7O4S. Mole weight: 569.63. | |
| ARRY-382 | ARRY-382 is a potent and selective inhibitor of the CSF1R with IC50 of 9 nM. ARRY-382 can be combined with Pembrolizumab for the treatment of advanced solid tumors. Synonyms: c-Fms-IN-12; ARRY382; ARRY 382. CAS No. 1313407-95-2. Molecular formula: C32H36N8O2. Mole weight: 564.68. | |
| ARRY 403 | ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151; (1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grade: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53. | |
| ARRY 520 hydrochloride | ARRY 520 hydrochloride is a kinesin spindle protein (Ksp) inhibitor with potential antineoplastic activity. Synonyms: Filanesib hydrochloride; (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide Hydrochloride; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, hydrochloride (1:1), (2S)-; ARRY-520 hydrochloride. Grade: 95%. CAS No. 1385020-40-5. Molecular formula: C20H23ClF2N4O2S. Mole weight: 456.94. | |
| ARRY-520 R enantiomer | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grade: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
| ARRY-797 | ARRY-797 is a potent and selective p38α inhibitor that inhibits LPS-induced IL-6. Synonyms: p38alpha inhibitor 1; p38α inhibitor 1; 5-(2,4-Difluorophenoxy)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H-indazole-6-carboxamide; 1H-Indazole-6-carboxamide, 5-(2,4-difluorophenoxy)-N-[2-(dimethylamino)ethyl]-1-(2-methylpropyl)-; ARRY 797; ARRY797. Grade: ≥95%. CAS No. 1036404-17-7. Molecular formula: C22H26F2N4O2. Mole weight: 416.46. | |
| ARS-1323 | ARS-1323 is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1323; ARS 1323; ARS1323; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one. CAS No. 1698024-73-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-1620 | ARS-1620 is a potent and selective KRAS-G12C inhibitor. ARS-1620 achieves rapid and sustained in vivo target occupancy to induce tumor regression. Synonyms: ARS-1620; ARS 1620; ARS1620; BCP29125; BCP 29125; BCP-29125; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one sulfane. CAS No. 1698055-85-4. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-1630 | ARS-1630 is the R-enantiomer of ARS-1620. It is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1630; ARS 1630; ARS1630; (R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one. CAS No. 1698055-86-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84. | |
| ARS-853 | ARS-853 is a selective, allele-specific inhibitor of KRAS, which blocks KRAS signaling and suppresses tumor growth (IC50 = 2.5 μM). Synonyms: ARS-853; ARS853; ARS 853; SCHEMBL16117872; AKOS032944976; CS-6065; CS 6065; CS6065; 1-[3-[4-[2-[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)anilino]acetyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one. Grade: 99.02 %. CAS No. 1629268-00-3. Molecular formula: C22H29ClN4O3. Mole weight: 432.94. | |
| ART558 | ART558 is a nanomolar potent, selective, allosteric DNA polymerase activity of Polθ inhibitor with IC50 of 7.9 nM. ART558 can be used in cancer research. Synonyms: GLXC-26260. CAS No. 2603528-97-6. Molecular formula: C21H21F3N4O2. Mole weight: 418.41. | |
| ART812 | ART812 is an orally active DNA polymerase Polθ inhibitor with IC 50 of 7.6 nM. ART812 also significantly inhibited PARP-resistant BRCA1 mutant tumor growth in rats. Synonyms: HY-139289. CAS No. 2607138-82-7. Molecular formula: C19H16ClF4N3O4. Mole weight: 461.79. | |
| ART-CHEM-BB B025267 | ART-CHEM-BB B025267 up-regulates the production of utrophin with an EC50 of 1.8 μM, which can be used in research on the treatment of Duchenne muscular dystrophy. Synonyms: 2-(4-(Diethylamino)phenyl)-6-methyl-2H-benzo[d][1,2,3]triazol-5-amine; 2-[4-(Diethylamino)phenyl]-6-methyl-2H-1,2,3-benzotriazol-5-amine; 2-[4-(Diethylamino)phenyl]-6-methyl-2H-benzotriazol-5-amine. Grade: ≥95%. CAS No. 381208-40-8. Molecular formula: C17H21N5. Mole weight: 295.38. | |
| Arteether | Artemotil is a fast-acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria. Uses: Amebicides. Synonyms: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]-2-benzopyran; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Ethoxydecahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,10α,12β,12aR*)]-; (+)-Arteether; Artemotil; Dihydroartemisinin ethyl ether; Dihydroqinghaosu ethyl ether; NSC 665971; SM 227; β-Arteether; β-Dihydroartemisinin ethyl ether. Grade: ≥95%. CAS No. 75887-54-6. Molecular formula: C17H28O5. Mole weight: 312.41. | |
| Artemether Impurity C | An impurity of Artemether. Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Synonyms: Artemether Tetrahydrofuran Acetate; (3aS,4R,6aS,7R,8S,10R,10aR)-Octahydro-8-methoxy-4,7-dimethyl-2H,10H-furo[3,2-i][2]benzopyran-10-ol 10-Acetate. Grade: > 95%. CAS No. 181528-64-3. Molecular formula: C16H26O5. Mole weight: 298.38. | |
| Artemifone | Artemifone is a potent and semi-synthetic antimalarial agent that can inhibit p. falciparum with an average IC50 value of 0.83 nM. It is also a potent human CMV inhibitor. Synonyms: Artemisone; BAY 44-9585; 4-[(3R,12aR)-3,6alpha,9beta-Trimethyl-3beta,12alpha-epoxy-3,4,5,5aalpha,6,7,8,8aalpha,9,10-decahydropyrano[4,3-j]-1,2-benzodioxepin-10alpha-yl]thiomorpholine 1,1-dioxide. Grade: ≥98%. CAS No. 255730-18-8. Molecular formula: C19H31NO6S. Mole weight: 401.52. | |
| Artemisinin Impurity B | A metabolite of Artemisinin. Synonyms: 9-epi Artemisinin. Grade: > 95%. CAS No. 113472-97-2. Molecular formula: C15H22O5. Mole weight: 282.34. | |
| Artemisitene (Methyl Artemisinin) | A derivative of Artemether. Artemether is an antimalarial for the treatment of multiple drug-resistant strains of Plasmodium falciparum malaria. Synonyms: (3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-dimethyl-9-methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one; (+)-Artemisitene Dehydroqinghaosu. Grade: > 95%. CAS No. 101020-89-7. Molecular formula: C15H20O5. Mole weight: 280.32. | |
| Arthrobacter stabilis exopolysaccharide | Arthrobacter stabilis exopolysaccharide (A. stabilis EPS) is a biopolymer produced by the bacterium Arthrobacter stabilis. This exopolysaccharide exhibits unique structural properties and has promising applications in various fields. It is recognized for its antimicrobial, antiviral, and immune-modulating properties, making it valuable in the biomedical sector. In the food industry, it serves as a thickener and stabilizer. Additionally, A. stabilis EPS is used in environmental protection for removing heavy metals and pollutants from water, and in cosmetics for its moisturizing and antioxidant benefits. Its diverse applications make it a significant area of ongoing research. Synonyms: A. stabilis EPS. | |
| Arthrobacter viscosus exopolysaccharide | Arthrobacter viscosus exopolysaccharide (A. viscosus EPS) is a biopolymer produced by the bacterium Arthrobacter viscosus. A. viscosus EPS has demonstrated potential antimicrobial, antiviral, and immunomodulatory properties. It is being studied for use in drug delivery systems and therapeutic applications. It serves as a thickening agent and stabilizer in various food products due to its ability to form gels and enhance texture. Synonyms: A. viscosus EPS. | |
| Articaine Hydrochloride | Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world. Synonyms: Articaine HCl; Articaine Hydrochloride; Carticaine HCl; Hoe-40045; Hoe-045; Carticaine Hydrochloride; Ultracaine. Grade: >98%. CAS No. 23964-57-0. Molecular formula: C13H20N2O3S.HCl. Mole weight: 320.84. | |
| Articaine Impurity A | A metabolite of Articaine. Synonyms: Acetamidoarticaine HCl. Grade: > 95%. CAS No. 1712677-79-6. Molecular formula: C12H18N2O3S HCl. Mole weight: 270.35 36.46. | |
| Articaine Impurity B | A metabolite of Articaine. Synonyms: Articaine Acid HCl. Grade: > 95%. CAS No. 114176-52-2. Molecular formula: C12H18N2O3S HCl. Mole weight: 270.35 36.46. | |
| Articaine Impurity E | A metabolite of Articaine. Synonyms: Isopropylarticaine HCl. Grade: > 95%. CAS No. 1796888-45-3. Molecular formula: C13H20N2O3S HCl. Mole weight: 284.38 36.46. | |
| Articaine Impurity G | A metabolite of Articaine. Synonyms: Butylarticaine HCl. Grade: > 95%. CAS No. 23964-59-2. Molecular formula: C14H22N2O3S HCl. Mole weight: 298.41 36.46. | |
| Articaine Impurity I | A metabolite of Articaine. Synonyms: Methyl 3-Amino-4-Methylthiophene-2-Carboxylate. Grade: > 95%. CAS No. 85006-31-1. Molecular formula: C7H9NO2S. Mole weight: 171.22. | |
| Arugosin C | Arugosin C is an anthraquinone derivative produced by the strain of Aspergillus found in the Red Sea. Synonyms: Arugosin C; 50875-10-0; CHEBI:68860; [1]Benzopyrano[4,5-bc][1]benzoxepin-7(2H)-one,1,12a-dihydro-6,8-dihydroxy-1-(1-hydroxy- 1-methylethyl)-4-methyl-9-(3-methyl-2- butenyl)-; FD39J64RWK; UNII-FD39J64RWK; 6,8-dihydroxy-1-(2-hydroxypropan-2-yl)-4-methyl-9-(3-methylbut-2-en-1-yl)-1,12a-dihydrochromeno[4,5-bc][1]benzoxepin-7(2h)-one; MLS004257379; CHEMBL3092848; SMR003082511; Q15410264; 1,12a-Dihydro-6,8-dihydroxy-1-(1-hydroxy-1-methylethyl)-4-methyl-9-(3-methylbut-2-enyl)(1)benzopy rano(4,5-bc)(1)benzoxepin-7(2H)-one; 1,12a-Dihydro-6,8-dihydroxy-1-(1-hydroxy-1-methylethyl)-4-methyl-9-(3-methylbut-2-enyl)(1)benzopyrano(4,5-bc)(1)benzoxepin-7(2H)-one. CAS No. 50875-10-0. Molecular formula: C25H28O6. Mole weight: 424.48. | |
| ARV-471 | ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grade: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90. | |
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grade: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. | |
| ARX-1796 | ARX-1796 is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes. Synonyms: AV-006. Grade: 98%. CAS No. 2245880-46-8. Molecular formula: C14H23N3O8S. Mole weight: 393.42. | |
| Arylomycin A2 | Arylomycin A is a lipopeptide compound with double aryl bridge produced by Streptomyces sp. Tu 6076. It has anti-Gram-positive bacteria activity. The most sensitive bacteria is Rhodococcus Ehmpolis. Molecular formula: C42H60N6O11. Mole weight: 824.97. | |
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