BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Apomine | Apomine is an HMG-CoA reductase inhibitor that promotes myeloma cell apoptosis in vitro and is involved in myeloma regulation in vivo. Synonyms: Phosphonic acid, P,P'-[2-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethylidene]bis-, P,P,P',P'-tetrakis(1-methylethyl) ester; Phosphonic acid, [2-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethylidene]bis-, tetrakis(1-methylethyl) ester; SKF 99085; SR 45023A; SR 9223i; Tetraisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl-1,1-diphosphonate. Grade: 95%. CAS No. 126411-13-0. Molecular formula: C28H52O7P2. Mole weight: 562.66. |  |
| Apoptosis Activator 2 | Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. It increases procaspase-9 processing and subsequent caspase-3 activation. It induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). Synonyms: Apoptosis Activator 2; AAII; N-(3,4-dichlorobenzyl) Isatin. MDK83190; MDK-83190; MDK 83190. CAS No. 79183-19-0. Molecular formula: C15H9Cl2NO2. Mole weight: 306.142. | |
| Apoptozole | Apoptozole, also known as Apoptosis Activator VII, is an apoptosis-inducing small molecule that inhibits the ATPase activity of heat shock cognate 70 (Hsc70) and Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM). Synonyms: 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide; Apoptozole; Apoptosis Activator VII. CAS No. 1054543-47-3. Molecular formula: C33H25F6N3O3. Mole weight: 625.57. | |
| Apostatin-1 | Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Synonyms: Apt-1. CAS No. 2559703-06-7. Molecular formula: C19H27N3OS. Mole weight: 345.50. | |
| Apovinicaminic acid hydrochloride | An impurity of Vinpocetine. Vinpocetine, isolated from the lesser periwinkle plant, is a derivative of the vinca alkaloid vincamine with an effect of cerebral blood-flow enhancing and neuroprotection. Vinpocetine was approved for the treatment of cerebrovascular disorders and age-related memory impairment in Eastern Europe. Synonyms: 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic acid, 13a-ethyl-2,3,5,6,13a,13b-hexahydro-, hydrochloride (1:1), (13aS,13bS)-; (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic acid hydrochloride; Apovincamin-22-oic acid hydrochloride; (+)-Apovincaminic acid hydrochloride; (+)-cis-Apovincaminic acid hydrochloride; (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride; cis-Apovincaminic acid hydrochloride; Apovincaminic acid hydrochloride. CAS No. 72296-47-0. Molecular formula: C20H22N2O2.HCl. Mole weight: 358.86. | |
| AppCp | AppCp is a formidable small molecule inhibitor, intelligently studying the enigma of inflammation-related maladies. Its astute focus gravitates towards captivating the capacious CpG oligodeoxynucleotide receptor, thereby orchestrating an exquisite modulation of the immune rejoinder. Synonyms: (AMPPCP); Adenosine-5'-[(β,γ)-methyleno]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C11H18N5O12P3 (free acid). Mole weight: 505.21 (free acid). | |
| AppNH2 | AppNH2 is indispensable in research of combating ailments including cancer, diabetes is and autoimmune disorders. This revolutionary creation assuming the role of both a mighty inhibitor and a formidable activator, skillfully honing in on crucial proteins and enzymes entangled in the labyrinthine pathways of pathological advancement. Profoundly effective is appNH2 harnesses its exceptional chemical attributes to govern intricate cellular dynamics, thereby fostering optimal physiological harmony. Synonyms: (AMPPN); Adenosine-5'-(β-amido)diphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C10H16N6O9P2 (free acid). Mole weight: 426.21 (free acid). | |
| AppNHp | AppNHp is a key recompound used in the biomedical industry for the research of nucleotide analogs and phosphorylation reactions. It plays a crucial role in the development of antiviral drugs, such as AppNHp-based inhibitors for HIV and hepatitis C virus. Synonyms: (AMPPNP); Adenosine-5'-[(β,γ)-imido]triphosphate, Tetralithium salt; AMPPNHP. Grade: ≥ 95% by HPLC. Molecular formula: C10H17N6O12P3 (free acid). Mole weight: 506.19 (free acid). | |
| APR-246 | APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. This agent may work synergistically with other antineoplastic agents. The Wrap53 transcript, a natural p53 antisense transcript, regulates endogenous p53 mRNA levels and additional induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Synonyms: PRIMA-1MET; Prima 1MET; Eprenetapopt; 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one. Grade: 98%. CAS No. 5291-32-7. Molecular formula: C10H17NO3. Mole weight: 199.25. | |
| Apraclonidine | Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 adrenergic receptor agonist. It enhances aqueous humor uveoscleral outflow and decreases aqueous production by vasoconstriction. It is a sympathomimetic used in glaucoma therapy. It was developed by Alcon and has been listed. Uses: Apraclonidine is a sympathomimetic used in glaucoma therapy. Synonyms: 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine; 2,6-Dichloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; Iopidine; 4-Aminoclonidine; Apraclonidina; Apraclonidinum; P-aminoclonidine. Grade: 98%. CAS No. 66711-21-5. Molecular formula: C9H10Cl2N4. Mole weight: 245.11. | |
| Apraclonidine hydrochloride | Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine. It is used for the treatment of post-surgical elevated intraocular pressure. It inhibits noradrenaline-stimulated contraction in guinea pig ileum with EC50s of 7.59 nM and rabbit vas deferens with EC50s of 6.76 nM. Uses: Adrenergic alpha-2 receptor agonists. Synonyms: ALO 2145; 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine hydrochloride; Iopidine; p-Aminoclonidine monohydrochloride. Grade: ≥98%. CAS No. 73218-79-8. Molecular formula: C9H10Cl2N4·HCl. Mole weight: 281.6. | |
| Apramycin Sulphate | Apramycin Sulphate, a potent aminoglycoside antibiotic, exhibits efficacy in combating bacterial infections in animals caused by an array of Gram-negative bacteria, with a notable specificity for Enterobacteriaceae. Its mechanism of action involves hindering protein synthesis within bacterial cells, rendering it a pivotal asset in the realm of veterinary medicine. Synonyms: D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:1); Apramycin sulfate; Apramycin sulfate salt; Nebramycin II sulfate; Nebramycin factor 2 sulfate; O-4-Amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-D-streptamine sulfate. CAS No. 410097-64-2. Molecular formula: C21H43N5O15S. Mole weight: 637.66. | |
| Apremilast | Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. Uses: Anti-inflammatory agents, non-steroidal; phosphodiesterase inhibitors. Synonyms: (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; CC 10004; CC10004; CC-10004. Grade: >98%. CAS No. 608141-41-9. Molecular formula: C22H24N2O7S. Mole weight: 460.50. | |
| Apremilast Dimer | Apremilast Dimer is an impurity of Apremilast, which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Synonyms: (S)-N-(2'-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,1',3,3'-tetraoxo-[2,4'-biisoindolin]-4-yl)acetamide. CAS No. 1802246-60-1. Molecular formula: C30H27N3O9S. Mole weight: 605.6. | |
| Apremilast Impurity 2 | A metabolite of Apremilast. Synonyms: (R)-Apremilast; N-[2-[(1R)?-1-(3-Ethoxy-4-methoxyphenyl)?-2-(methylsulfonyl)?ethyl]?-2,?3-dihydro-1,?3-dioxo-1H-isoindol-4-yl]?-acetamide. Grade: > 95%. CAS No. 608141-44-2. Molecular formula: C22H24N2O7S. Mole weight: 460.51. | |
| Aprepitant | Aprepitant is a specific NK-1R antagonist, used as an antiemetic agent. Synonyms: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436. Grade: 98%. CAS No. 170729-80-3. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. | |
| Aprepitant diastereomers (R,R,R and R,S,S) | An isomer of Aprepitant. Aprepitant is a selective neurokinin-1 (NK-1) receptor antagonist used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: (R,R,R)-Aprepitant and (R,S,S)-Aprepitant; Aprepitant R,R,R-Diastereomer and Aprepitant R,S,S-Diastereomer; (1R,2R,3R)-Aprepitant and (1S,2R,3S)-Aprepitant; 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one and 3-[[(2R,3S)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one. Grade: ≥95%. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. | |
| Aprepitant EP Impurity B | Aprepitant EP Impurity B is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 4-Defluoro-3-(p-fluorophenyl) Aprepitant; Aprepitant Impurity B; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-ethoxy]-3-(4'-fluorobiphenyl-3-yl)morpholin-4-yl]-methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-3-yl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-3-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one. Grade: ≥95%. CAS No. 2348441-62-1. Molecular formula: C29H25F7N4O3. Mole weight: 610.52. | |
| Aprepitant EP Impurity C | Aprepitant EP Impurity C is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Aprepitant Impurity C; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-ethoxy]-3-(4'-fluorobiphenyl-4-yl)morpholin-4-yl]-methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one; 4-Defluoro-4-(p-fluorophenyl)aprepitant; 4-Defluoro-4-(p-fluorophenyl) Aprepitant. Grade: ≥95%. CAS No. 2348441-63-2. Molecular formula: C29H25F7N4O3. Mole weight: 610.52. | |
| Aprepitant glucuronide | Aprepitant glucuronide is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C29H29F7N4O9. Mole weight: 710.55. | |
| Aprepitant Impurity 1 | A metabolite of Aprepitant. Synonyms: (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-morpholine. Grade: > 95%. CAS No. 327623-37-0. Molecular formula: C20H18F7NO2. HCl. Mole weight: 437.36. | |
| Aprepitant Impurity 10 HCl | Aprepitant Impurity 10 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: (2R,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride; 1447693-83-5. CAS No. 1447693-83-5. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 11 HCl | Aprepitant Impurity 11 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 12 HCl | Aprepitant Impurity 12 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 13 | Aprepitant Impurity 13 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C29H25F7N4O3. Mole weight: 610.52. | |
| Aprepitant Impurity 14 | Aprepitant Impurity 14 is a derivative of Aprepitant, which is a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3-Des-(4-fluorophenyl) 3-(R)-(4'-Fluorobiphen-4-yl) Aprepitant. Molecular formula: C29H25F7N4O3. Mole weight: 610.52. | |
| Aprepitant Impurity 15 | Aprepitant Impurity 15 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C23H22F6N4O4. Mole weight: 532.43. | |
| Aprepitant Impurity 16 | Aprepitant Impurity 16 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 638990-20-2. Molecular formula: C22H24N2O5. Mole weight: 396.44. | |
| Aprepitant Impurity 17 | Aprepitant Impurity 17 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C21H19F6NO3. Mole weight: 447.37. | |
| Aprepitant Impurity 18 | Aprepitant Impurity 18 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C12H7F9O2. Mole weight: 354.17. | |
| Aprepitant Impurity 19 | Aprepitant Impurity 19 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 3,7-Dimethyl-3-octanol. CAS No. 78-69-3. Molecular formula: C10H22O. Mole weight: 158.28. | |
| Aprepitant Impurity 1 Enantiomer HCl | A metabolite of Aprepitant. Synonyms: (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-Morpholin. Grade: > 95%. CAS No. 171482-05-6. Molecular formula: C20H18F7NO2. HCl. Mole weight: 437.36 36.46. | |
| Aprepitant Impurity 1 HCl | Aprepitant Impurity 1 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 2 | Aprepitant Impurity 2 is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C24H25F7N4O4. Mole weight: 566.47. | |
| Aprepitant Impurity 4 HCl | Aprepitant Impurity 4 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 1333998-21-2. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 5 HCl | Aprepitant Impurity 5 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. CAS No. 1333995-14-4. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 7 HCl | Aprepitant Impurity 7 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1'S)-Aprepitant Hydrochloride. CAS No. 874460-46-5. Molecular formula: C20H19F6NO2.HCl. Mole weight: 455.82. | |
| Aprepitant Impurity 8 HCl | Aprepitant Impurity 8 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Fosaprepitant Morpholine Hydrochloride; (2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333998-27-8. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant impurity A | Aprepitant impurity A is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47. | |
| Aprepitant Impurity A Enantiomer | Aprepitant Impurity A Enantiomer is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47. | |
| Aprepitant Impurity B Enantiomer HCl | A metabolite of Aprepitant. Synonyms: (2R,3S)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine. Grade: > 95%. CAS No. 183901-47-5. Molecular formula: C27H24F7NO2. HCl. Mole weight: 527.49 36.46. | |
| Aprepitant Impurity B HCl | Aprepitant Impurity B HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2.HCl. Mole weight: 563.93. | |
| Aprepitant-M3 Metabolite | Aprepitant-M3 Metabolite is a metabolite of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: An active metabolite of aprepitant. Synonyms: (5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone; Aprepitant-M3; 3-Morpholinone, 6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-, (5S,6R)-. Grade: ≥95%. CAS No. 419574-04-2. Molecular formula: C20H16F7NO3. Mole weight: 451.33. | |
| Aprepitant open ring methyl ester | Aprepitant open ring methyl ester is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: N-(Destriazolonomethyl) N-(Methylcarboxyacetamidohydrazono) Aprepitant; Hydrazinecarboxylic acid, 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]-, methyl ester; Methyl 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylate; Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)-1-iminoethyl)hydrazine-1-carboxylate; Aprepitant Open-Ring Methyl Ester Impurity. Grade: ≥95%. CAS No. 219821-37-1. Molecular formula: C24H25F7N4O4. Mole weight: 566.48. | |
| Apricitabine | Apricitabine is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki = 0.08 μM), with Kis of 300, 12 and 112.25 μM against DNA polymerase α, β and γ, respectively. It has been used in trials studying the treatment of HIV Infections. Synonyms: Apricitabine; 160707-69-7; AVX754; AVX-754; SPD754; Apricitabine [INN]; BCH 10618; BCH-10618; SPD-754; (-)-dOTC; 4-Amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one; 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one; K1YX059ML1; SPD -754; BCH-10619; BCH-10652; BCH-10652, (-)-; AVX 754; (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine); 2(1H)-Pyrimid. Grade: 95%. CAS No. 160707-69-7. Molecular formula: C8H11N3O3S. Mole weight: 229.26. | |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| Aprindine | Aprindine is a Class 1b antiarrhythmic agent as a cardiac depressant used in arrhythmias. Uses: A cardiac depressant used in arrhythmias. Synonyms: N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine. Grade: ≥98%. CAS No. 37640-71-4. Molecular formula: C22H30N2. Mole weight: 322.48. | |
| Aprindine hydrochloride | Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies. Synonyms: N1-(2,3-Dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-1,3-propanediamine Hydrochloride; N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine; Amidonal; Aspenon; Compd 83846; Fibocil; Fiboran; MS 5075; NSC 284614; Ritmusin. Grade: 95%. CAS No. 33237-74-0. Molecular formula: C22H31ClN2. Mole weight: 358.95. | |
| Aprutumab | Aprutumab is a humanized monoclonal antibody directed against FGFR2. Aprutumab has been used in the research of solid tumors. Synonyms: BAY 1179470; BAY-1179470; BAY1179470. CAS No. 1634620-63-5. | |
| APS-2-79 | APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Synonyms: 6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; APS-2-79; APS 2-79; APS2-79; APS-279; APS 279; APS279. CAS No. 2002381-25-9. Molecular formula: C23H21N3O3. Mole weight: 387.43. | |
| APS-2-79 HCl | APS-2-79 is a MAPK antagonist which can modulate KSR-dependent MAPK signalling by antagonizing RAF heterodimerization and the conformational changes required for phosphorylation and activation of KSR-bound MEK. APS-2-79 was found to bind to the KSR active site with an IC50 value of 120 nM, antagonizing MEK (MAPKK) phosphorylation by RAF. Synonyms: APS-2-79 HCl; APS2-79 HCl; APS 2-79 HCl; APS-279 HCl; APS279 HCl; APS 279 HCl; SCHEMBL18153640; AKOS032944984; CS-6151; 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; hydrochloride. Grade: 99.26 %. CAS No. 2002381-31-7. Molecular formula: C23H21N3O3.HCl. Mole weight: 423.89. | |
| APS6-45 | APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that strongly inhibits RAS pathway signaling in human MTC cell lines TT and MZ-CRC-1. Synonyms: 4-(4-(3-(2-fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide; APS645; APS6 45; APS-645; APS 645. Grade: >98%. CAS No. 2188236-41-9. Molecular formula: C23H16F8N4O3. Mole weight: 548.39. | |
| APS sodium salt | APS is an active sulfate ester of 5'-AMP, which is used in pyrosequencing and bioluminescence applications. Synonyms: Adenosine- 5'- O- phosphosulfate, sodium salt. Grade: 85%. CAS No. 102029-95-8. Molecular formula: C10H14N5O10PS (free acid). Mole weight: 427.3 (free acid). | |
| Aptazapine | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: CGS 7525 A; 2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine; 71576-41-5 (maleate). Grade: 98%. CAS No. 71576-40-4. Molecular formula: C16H19N3. Mole weight: 253.35. | |
| Aptazapine maleate | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: (+-)-1,3,4,14b-Tetrahydro-2-methyl-2H,10H-pyrazino(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine maleate (1:1). Grade: 98%. CAS No. 71576-41-5. Molecular formula: C16H19N3.C4H4O4. Mole weight: 369.42. | |
| APTO-253 hydrochloride | APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis. Synonyms: APTO 253 hydrochloride; APTO253 hydrochloride; LOR253 hydrochloride; LOR-253 hydrochloride; LOR 253 hydrochloride. CAS No. 1422731-37-0. Molecular formula: C22H15ClFN5. Mole weight: 403.85. | |
| APTSTAT3-9R | APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets. Treatment of various types of cancer cells with APTSTAT3-9R blocked STAT3 phosphorylation and reduced expression of STAT targets, including cyclin D1, Bcl-xL, and survivin. As a result, APTSTAT3-9R suppressed the viability and proliferation of cancer cells. Furthermore, intratumoral injection of APTSTAT3-9R exerted potent antitumor activity in both xenograft and allograft tumor models. Synonyms: H-DL-His-Gly-DL-Phe-DL-Gln-DL-Trp-DL-Pro-Gly-DL-Ser-DL-Trp-DL-xiThr-DL-Trp-DL-Glu-DL-Asn-Gly-DL-Lys-DL-Trp-DL-xiThr-DL-Trp-DL-Lys-Gly-DL-Ala-DL-Tyr-DL-Gln-DL-Phe-DL-Leu-DL-Lys-Gly-Gly-Gly-Gly-DL-Ser-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-OH; HGFQWPGSWXWENGKWXWKGAYQFLKGGGGSRRRRRRRRR; DL-histidyl-glycyl-DL-phenylalanyl-DL-glutaminyl-DL-tryptophyl-DL-prolyl-glycyl-DL-seryl-DL-. Grade: 99.31 %. Molecular formula: C223H330N80O51. Mole weight: 4947.51. | |
| APX001A | APX001A is a first-in-class small-molecule inhibitor of the conserved fungal Gwt1 protein. APX001A is active against the major fungal pathogens, i.e., Candida (except Candida krusei), Aspergillus, and hard-to-treat molds, including Fusarium and Scedosporium. Synonyms: MGX; Manogepix; E1210. CAS No. 936339-60-5. Molecular formula: C21H18N4O2. Mole weight: 358.39. | |
| APX-115 | APX-115 is a first-in-class pan-NADPH oxidase (Nox) inhibitor. Study shows that APX-115 might be a promising therapeutic agent for the treatment of diabetic nephropathy because of its pan-NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti-inflammatory effect. Synonyms: Ewha-18278; Isuzinaxib hydrochloride; 3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride. Grade: 99%. CAS No. 1395946-75-4. Molecular formula: C17H17N3O.HCl. Mole weight: 315.80. | |
| APY0201 | APY0201, an effective IL-12/23 inhibitor, has been found to have potential use in the treatment of inflammation. IC50 = 5.2 nM. Synonyms: APY0201; APY-0201; APY 0201. Grade: 98%. CAS No. 1232221-74-7. Molecular formula: C23H23N7O. Mole weight: 413.48. | |
| APY29 | Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity. Synonyms: APY29; APY-29; APY 29; N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine. Grade: >98%. CAS No. 1216665-49-4. Molecular formula: C17H16N8. Mole weight: 332.36. | |
| Apyramide | Apyramide is a non-steroidal anti-inflammatory agent (NSAID) that is a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable, non-selective inhibitor of COX1 and COX2. Synonyms: 4-(Acetylamino)phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate; 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-p-acetamidophenol acetate; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(acetylamino)phenyl ester. Grade: ≥95%. CAS No. 68483-33-0. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| AQ-RA 741 | AQ-RA 741 has been found to be a muscarinic M2 receptor antagonist and could probably be used in the development of bronchodilator anti-muscarinic agent. Synonyms: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one. Grade: ≥99% by HPLC. CAS No. 123548-16-3. Molecular formula: C27H37N5O2. Mole weight: 463.62. | |
| AquaPhluor® 593 CPG | AquaPhluor® 593 CPG is a fluorescent dye used to analyze RNA and DNA sequences in the biomedical industry. It is often used in conjunction with oligonucleotides to detect and quantify the expression levels of genes associated with diseases such as cancer or viral infections. Its unique water-soluble nature allows for easy use in aqueous environments. Synonyms: AquaPhluor 593 (1000 Å); Aquafluor 593 CPG (1000 Å); AquaPhluor® 593 CPG 1000Å; AquaPhluor 593 CPG; 2,3,6,7,12,13,16,17-Octohydro-1H,5H,11H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium-9-yl-[(2-diethylaminocarbonyl)-phen-4-yl]-phosphoryl-hexanoyl-1-(2-O-dimethoxytrityloxymethyl)-pyrrolidin-4-yl-succinoyl long chain alkylamino-CPG. | |
| AquaPhluor® 639 CPG | AquaPhluor® 639 CPG is a fluorescent dye that is commonly used in the biomedical industry as a labeling agent for oligonucleotides and DNA to study gene expression and function. Additionally, it has been used to track cancer cell migration and proliferation in vitro. Synonyms: AquaPhluor® 639 CPG 1000Å; 6-[2,3,16,17-tetrahydro-5,5,7,11,13,13-hexamethyl-1H,5H,13H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium-9-yl-[2-chloro-6-(N-hydroxysulfonylethyl-N'-methylaminocarbonyl)-phen-4-yl][trifluoroacetylaminobutoxy]phosphoryl][oxy]-hexanoyl-1-(2-O-dimethoxytrityloxymethyl)-pyrrolidin-4-yl-succinoyl long chain alkylamino-CPG; AquaPhluor 639 CPG. | |
| Aquastatin B | Aquastatin B is an extraordinary compound, standing as a magnificent tool in studying hypertension and cardiovascular diseases, functioning as a remarkable inhibitor of angiotensin-converting enzyme (ACE). Synonyms: Aquqstatin B. CAS No. 160219-85-2. Molecular formula: C30H42O7. Mole weight: 514.65. | |
| Aquastatin C | Aquastatin C is a new glycoaromatic derivative originally isolated from Sporothrix sp. FN611. Synonyms: Aquqstatin C. CAS No. 1344044-32-1. Molecular formula: C29H48O9. Mole weight: 540.68. | |
| Aquocobalamin | One of the analog of Vitamin B12, which has been found to be related to the metabolism of cells in human body, especially DNA synthesis, amino acid as well as fatty acid metabolism. Synonyms: Cobinamide, Co-aqua-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), ion(1+), hydroxide (1:1); Cobinamide, dihydroxide, monohydrate, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole; Cobinamide, hydroxide, monohydrate, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; Aquacobalamin; Aquocobalamin hydroxide; Aquocobalamine; Cobalamin, aquo-; Vitamin B12b. Grade: ≥95%. CAS No. 13422-52-1. Molecular formula: C62H91CoN13O16P. Mole weight: 1364.37. | |
| AQX-016A | AQX-016A is a potent agonist of SHIP1 that induces apoptosis of the cancer cell lines in vitro in both a time and dose dependant manner. Synonyms: CID 45028212. CAS No. 849669-54-1. Molecular formula: C22H32O2. Mole weight: 328.49. | |
| AQX-435 | AQX-435 is a SHIP1 Phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth. Synonyms: AQX 435; AQX435; N-((2R,3S,4S,4aS,8aS)-4-(3,5-dihydroxybenzoyl)-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl)nicotinamide. CAS No. 1619983-52-6. Molecular formula: C27H34N2O4. Mole weight: 450.58. | |
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