BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Antithrombin III | Antithrombin III is a vital protein in the biomedical industry known for its role in studying blood clot formation. This product is commonly used in the research of various disorders associated with coagulation, such as deep vein thrombosis, pulmonary embolism and disseminated intravascular coagulation. It effectively inhibits specific enzymes involved in the blood clotting cascade. Synonyms: Antithrombin; Antithrombins; AT III; Atenativ; Heparin cofactor; Heparin cofactor B; Kybernin; Kybernin HS; Neuart; Org 10849; Serpin C1; Thrombin inhibitor; Thrombin inhibitors. CAS No. 9000-94-6. |  |
| anti-TNBC agent-1 | Anti-TNBC agent-1 is a novel inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. Anti-TNBC agent-1 induces apoptosis of SUM-159 cells through mitochondria pathway and causes G1 phase arrest of SUM-159 cells. Synonyms: anti-TNBC agent-1; AKOS040757524; HY-145143; CS-0356584; 2289585-58-4. CAS No. 2289585-58-4. Molecular formula: C26H30O7. Mole weight: 454.52. | |
| Antitrypanosomal agent 1 | Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase (TR), with an IC50 of 3.3 μM. It inhibits glutathione reductase (GR) (IC50 = 64.8 μM) and T. brucei (EC50 = 1 μM). Synonyms: 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanone HCl; NSC-304108. Grade: ≥95%. CAS No. 75144-12-6. Molecular formula: C11H14Cl3NO. Mole weight: 282.59. | |
| Antitrypanosomal agent 2 | Antitrypanosomal agent 2 is a potent and selective inhibitor of trypanosoma brucei. Synonyms: 3-(3-phenyl-4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)-1H-pyrazol-1-yl)propanenitrile. CAS No. 475626-30-3. Molecular formula: C17H13N5O3. Mole weight: 335.32. | |
| Antitubercular agent-10 | Antitubercular agent-10 shows potent antitubercular activity (MIC = 30 nM). CAS No. 2679830-78-3. Molecular formula: C19H15N5O6S2. Mole weight: 473.48. | |
| Antitubercular agent-30 | Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). It has antitubercular activity. Synonyms: N-(4-nitrophenyl)-2-(2-thienyl)acetamide; N-(4-Nitro-phenyl)-2-thiophen-2-yl-acetamide; WAY-297407. CAS No. 384857-54-9. Molecular formula: C12H10N2O3S. Mole weight: 262.29. | |
| Antitubercular agent-9 | Antitubercular agent-9 displays effective antitubercular activity with an MIC value of 1.03-2.32 μM. Synonyms: Antitubercular agent-9; AKOS040757995; HY-132910; CS-0254742; 2722634-44-6. CAS No. 2722634-44-6. Molecular formula: C32H24ClN7O4. Mole weight: 606.03. | |
| Antitumor agent-28 | Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Synonyms: Antitumor agent-28; AKOS040757276; HY-141478; CS-0173192; 2097499-67-5. CAS No. 2097499-67-5. Molecular formula: C25H32N6O4S. Mole weight: 512.62. | |
| Antitumor agent-36 | Antitumor agent-36 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-36 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. It also significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues. Molecular formula: C32H30Cl2N2O6Pt. Mole weight: 804.58. | |
| Antitumor agent-37 | Antitumor agent-37 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-37 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. It also significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues. Molecular formula: C16H18Cl2N2O4Pt. Mole weight: 568.32. | |
| Antitumor Compound 1 | Antitumor Compound 1 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient. Synonyms: MDK-6303; MDK 6303; MDK6303; Antitumor Compound 1. Grade: >98%. CAS No. 420126-30-3. Molecular formula: C18H10F6N4S. Mole weight: 428.35. | |
| Antiviral agent 10 | Antiviral agent 10 is an antiviral agent and it can inhibit respiratory syncytial virus (RSV). Synonyms: Antiviral agent 10|Oprea1_361031|Oprea1_640984|SCHEMBL14825202|AKOS001021721|AKOS016377083|HY-142009|CS-0311654. Grade: ≥98% (HPLC). CAS No. 312615-62-6. Molecular formula: C22H24N2O5. Mole weight: 396.44. | |
| Antiviral agent 12 | N-(1-Benzyl-4-piperidyl)adamantane-1-carboxamide inhibits Ebola virus entry into host cells by binding to surface glycoproteins, and it inhibits the Ebola virus with an EC50 of 3.9 μM. Synonyms: 314030-54-1; N-(1-benzylpiperidin-4-yl)adamantane-1-carboxamide; Antiviral agent 12; N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide; Oprea1_394577; Oprea1_833933; CHEMBL1621026; SCHEMBL19172948; EX-A4094; AKOS000671998; PD158745; TS-09814; HY-115848; CS-0369318; Z68296869. Grade: ≥95%. CAS No. 314030-54-1. Molecular formula: C6H15ClN2O2. Mole weight: 186.67. | |
| Antiviral agent 24 | N6-(3-Trifluoromethylbenzyl)adenosine is a biomedical compound in the research of diverse ailments, exhibiting remarkable potential as an adenosine receptor agonist. Its profound influence on neurotransmitter regulation renders it highly efficacious in studying neurological disorders, cardiovascular afflictions and inflammation-related conditions. Synonyms: Antiviral agent 24; 23661-03-2; N6-(3-Trifluoromethylbenzyl)adenosine; 1-(|A-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine; SCHEMBL641041; CHEMBL225766; SDQKDCSBWUSBDO-LSCFUAHRSA-N; MS-27485; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[3-(trifluoromethyl)phenyl]methylamino]purin-9-yl]oxolane-3,4-diol. Grade: ≥95%. CAS No. 23661-03-2. Molecular formula: C21H20O9. Mole weight: 416.4. | |
| Antiviral agent 5 | An intermediate in the numerous antiviral protease inhibitors is the glutamine analogue. Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases including SARS-CoV-2 Mpro. Synonyms: Antiviral agent 5|CS-0227298. Grade: ≥98% (HPLC). CAS No. 2698336-82-0. Molecular formula: C18H30N2O7. Mole weight: 386.44. | |
| Antiviral agent 52 | Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). It is a blood-borne virus, which can cause both acute and chronic hepatitis. CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection with EC50 of 17 nM. It displays good pharmacokinetics in mice with preferential liver distribution without significant hepatotoxicity. CAY10704 is also selective for HCV over dengue virus with EC50 of 4.62 μM. Synonyms: 101784-44-5; 1-(Bis(4-chlorophenyl)methyl)-4-methylpiperazine; Antiviral agent 52; 1-[bis(4-chlorophenyl)methyl]-4-methylpiperazine; 1-[bis(4-chlorophenyl)methyl]-4-methyl-piperazine; CAY10704; SCHEMBL2056217; CHEMBL3771316; BEA78444; AKOS040755846; HY-113860; CS-0062963. Grade: ≥98%. CAS No. 101784-44-5. Molecular formula: C18H20Cl2N2. Mole weight: 335.27. | |
| Antiviral agent 9 | Antiviral agent 9 reaches a single-digit picomolar EC50 value (0.006 nM) against HIV-1 and nearly 300-fold higher selectivity index (SI) compared to tenofovir alafenamide fumarate (TAF). Synonyms: Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(4-((S)-2-(((benzyloxy)carbonyl)amino)-4-cyclopentyl-3-oxobutyl)phenoxy)phosphoryl)-L-alaninate. Molecular formula: C38H50N7O8P. Mole weight: 763.82. | |
| Ant-m7GDP | Ant-m7GDP is an exceptional pharmacological compound characterized by its profound capacity to combat viral infections. This awe-inspiring compound exhibits an unparalleled proclivity for selectively targeting and disrupting the intricate guanosine triphosphate cap structures, thereby impeding the vital process of viral mRNA capping. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-diphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H22N6O12P2 (free acid). Mole weight: 576.35 (free acid). | |
| Ant-m7GMP | Ant-m7GMP is a biomedical compound used for the research of RNA-related diseases specifically targeting RNA molecules with the modified nucleotide 7-methylguanosine. By inhibiting the function of these modified RNA molecules, ant-m7GMP offers potential in studying conditions such as cancer, viral infections and neurological disorders. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-monophosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H21N6O9P (free acid). Mole weight: 496.37 (free acid). | |
| Ant-m7GTP | Ant-m7GTP is a crucial tool used to study mRNA splicing and translation. It assists in investigating cellular processes and protein research. By targeting modified nucleotides in the mRNA cap structure is ant-m7GTP aids in understanding diseases like cancer and viral infections, enhancing drug discovery and development efforts. Synonyms: 2'/3'-O-Anthraniloyl-7-methylguanosine-5'-triphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H24N6O15P3 (free acid). Mole weight: 656.33 (free acid). | |
| Antofloxacin | Antofloxacin is an orally active and broad-spectrum 8-amino-fluoroquinolone with potent antibacterial activities. Antofloxacin shows superior antibacterial activity against gyrA mutation-positive H. pylori strains, especially in Asn87- mutated strains, compared to levofloxacin. Uses: Anti-bacterial agents. Synonyms: (S)-Antofloxacin; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 8-amino-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3S)-. CAS No. 119354-43-7. Molecular formula: C18H21FN4O4. Mole weight: 376.38. | |
| Antofloxacin hydrochloride | Antofloxacin hydrochloride is a well tolerate, orally active and broad-spectrum 8-amino-fluoroquinolone antibiotic with potent antibacterial activities. Anthofloxacin hydrochloride is a weak, reversible CYP1A2 inhibitor for the treatment of various bacterial infections. It is also used to treat acute exacerbation of chronic bronchitis (AECB), acute pyelonephritis (AP), acute cystitis and multiple folliculitis. Uses: Anti-bacterial agents. Synonyms: (S)-Antofloxacin hydrochloride; (S)-8-amino-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride; 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 8-amino-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrochloride (1:1), (3S)-. Grade: ≥95%. CAS No. 873888-67-6. Molecular formula: C18H22ClFN4O4. Mole weight: 412.84. | |
| Antrafenine Dihydrochloride | Antrafenine Dihydrochloride is the dihydrochloride form of Antrafenine, which is a piperazine derivative drug. It acts as an analgesic and anti-inflammatory drug, but is not widely used. Uses: Antrafenine dihydrochloride acts as an analgesic and anti-inflammatory drug. Synonyms: 2-[[7-(TrifluoroMethyl)-4-quinolinyl]amino]benzoic Acid [4-[3-(TrifluoroMethyl)phenyl]-1-piperazinyl]ethyl Ester dihydrochloride; Benzoic acid, 2-((7-(trifluoromethyl)-4-quinolinyl)amino)-, 2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl ester, dihydrochloride. Grade: 98%. CAS No. 55300-30-6. Molecular formula: C30H28Cl2F6N4O2. Mole weight: 661.47. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| AOH1160 | AOH1160 is a first-in-class, potent and orally available inhibitor of PCNA, which plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. AOH1160 selectively kills many types of cancer cells at below micromolar concentrations without causing significant toxicity to a broad range of nonmalignant cells. Synonyms: N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide. Grade: 99%. CAS No. 2089314-57-6. Molecular formula: C25H20N2O3. Mole weight: 396.44. | |
| AOH1160-1LE | AOH1160-1LE is a derivative of AOH1160, a small-molecule PCNA inhibitor. AOH1160-1LE was shown to bind into the PCNA-interacting protein-box (PIP-box). Molecular formula: C28H24N2O5. Mole weight: 468.50. | |
| AOH1996 | AOH1996 is a small-molecule PCNA inhibitor that enhances the interaction between PCNA and the largest subunit of RNA polymerase II, RPB1, and dissociates PCNA from actively transcribed chromatin regions, while inducing DNA double-stranded breaks in a transcription-dependent manner. AOH1996 was identified as a selective chemotherapeutic. Synonyms: AOH 1996; AOH-1996; NSC789796; NSC-789796. Grade: 98%. CAS No. 2089314-64-5. Molecular formula: C26H22N2O4. Mole weight: 426.46. | |
| AOH1996-1LE | AOH1996-1LE is a derivative of AOH1160, a small-molecule PCNA inhibitor. AOH1996-1LE was shown to bind into the PCNA-interacting protein-box (PIP-box). | |
| AP 1189 | AP 1189 exhibits biased agonistic activity towards the melanocortin 1 and melanocortin 3 receptors. Synonyms: Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, acetate (1:1), (2E)-; AP1189; AP-1189; Resomelagon acetate; (E)-2-((E)-3-(1-(2-nitrophenyl)-1H-pyrrol-2-yl)allylidene)hydrazine-1-carboximidamide acetate. Grade: ≥95%. CAS No. 1809420-72-1. Molecular formula: C14H14N6O2.C2H4O2. Mole weight: 358.35. | |
| AP14145 hydrochloride | AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. CAS No. 2387505-59-9. Molecular formula: C18H18ClF3N4O. Mole weight: 398.81. | |
| AP18 | AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 μM at human and mouse respectively. It has been used to study TRPA1 signaling in mice and rats as well as in vitro. It blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. It also blocks cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. It reverses CFA-induced mechanical hyperalgesia in mice. Uses: Ap18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. Synonyms: AP-18; AP 18; AP18. 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime; AP-18; 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime; (NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine; (2E,3E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime. Grade: 98%. CAS No. 55224-94-7. Molecular formula: C11H12ClNO. Mole weight: 209.67. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grade: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grade: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
| AP-1/NF-κB activation inhibitor 1 | AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor with an IC50 of 1 μM. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells. Synonyms: AP-1/NF-kappaB activation inhibitor 1; 2-(Trifluoromethyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl ester. Grade: 99%. CAS No. 188936-12-1. Molecular formula: C13H11F3N4O4. Mole weight: 344.25. | |
| AP20187 | Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice. AP20187 stimulation significantly increases hepatic glycogen content and muscular glucose uptake similarly to insulin. The homodimerizer has been widely used to study signal transduction pathways (by inducing oligomerization of cell surface receptor proteins), but it can be used to induce the activity/re-localization of any protein that is affected by oligomerization. To test the role of homodimerization in kinase activation, we constructed a fusion protein consisting of the SLK catalytic domain (amino acids 1-373) and a modified FK506 binding protein, Fv (Fv-SLK 1-373). Addition of AP20187 (an analog of FK506) enhanced the homodimerization of Fv-SLK 1-373. Synonyms: AP 20187; AP-20187. Grade: >98%. CAS No. 195514-80-8. Molecular formula: C82H107N5O20. Mole weight: 1482.75. | |
| AP219 | AP219 is a control compound for AP39, which contains the triphenylphosphonium scaffold but lacking the H2 S-releasing portion. AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. Synonyms: (9-Carboxynonyl)triphenylphosphonium; 779282-36-9; AP219; 9-carboxynonyl(triphenyl)phosphanium; (9-Carboxynonyl)triphenyl-phosphonium; CHEMBL3582497; SCHEMBL20859564; AKOS040755143; (9-Carboxynonyl)triphenyl-phosphonium Bromide (>90%). Grade: ≥98%. CAS No. 779282-36-9. Molecular formula: C28H34O2P. Mole weight: 433.6. | |
| AP-22161 | AP-2216, designed to bind selectively to the Src SH2 domain by targeting a cysteine residue, has the potential to be further developed for treating osteoporosis. Synonyms: 4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-formylbenzoic acid; AP-22161; AP 22161; AP22161; SCHEMBL7243003; G7VE62573J; UNII-G7VE62573J. Grade: >98%. CAS No. 268741-42-0. Molecular formula: C32H39N3O7. Mole weight: 577.67. | |
| AP2238 | AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Uses: Cholinesterase inhibitors. Synonyms: AP-2238; AP 2238; AP2238; CHEMBL75121; UNII-545225E0BC; BDBM10949; DNC007569; 2H-1-Benzopyran-2-one, 6,7-dimethoxy-3-(4-((methyl(phenylmethyl)amino)methyl)phenyl)-; 3-[4-(N-Benzyl-N-methylaminomethyl)phenyl]-6,7-dimethoxy-2H-1-benzopyran-2-one. Grade: 98%. CAS No. 553681-56-4. Molecular formula: C26H25NO4. Mole weight: 415.48. | |
| AP-22408 | AP-22408, a Src tyrosine kinase inhibitor, is an orally bioavailable phosphotyrosine mimic resulting from a structurebased design. Synonyms: [4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-phosphonophenyl]phosphonic acid; AP-22408; AP 22408; AP22408; UNII-3U3L5QR4KV; CC1; AC1L9I7C; 3U3L5QR4KV; SCHEMBL7245569. Grade: >98%. CAS No. 268741-43-1. Molecular formula: C30H41N3O10P2. Mole weight: 665.61. | |
| AP23464 | AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases. It displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells with an IC50=14 nM. Synonyms: AP-23464; AP 23464; (4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dimethylphosphine oxide. Grade: >98%. CAS No. 845895-51-4. Molecular formula: C30H38N5O2P. Mole weight: 475.53. | |
| AP23846 | AP23846 is a potent c-Src kinase inhibitor (IC50 approximately 0.5 nmol/L in vitro, approximately 10-fold more potent than PP2, the most widely used commercially available Src family kinase inhibitor). Synonyms: AP-23846; (4-((2-cyclopentyl-9-ethyl-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 878654-51-4. Molecular formula: C20H16FN3O2. Mole weight: 439.53. | |
| AP23848 | AP23848 is a potent Bcr-Abl inhibitor. Synonyms: AP-23848; AP 23848; PF-562771; (4-((2-Cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 834894-21-2. Molecular formula: C13H15N5O6. Mole weight: 531.63. | |
| AP-24600 | AP-24600 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AP-24600; AP 24600; AP24600; DA-12847; KB-310048; DA 12847; KB 310048; DA12847; KB310048; UNII-OZ477A282R; OZ477A282R; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid. Grade: 98%. CAS No. 1300690-48-5. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grade: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
| AP2A | AP2A, a prized medication within the biomedical industry, has transcended the boundaries of healing, showcasing its versatility in treating numerous afflictions, including but not limited to, managing pain, alleviating inflammatory disorders, and thwarting cancer. Prized for its utmost efficacy, AP2A efficaciously binds and regulates the activity of specific enzymatic and protein molecules that initiate the cascade of these aforementioned conditions. With its potential for therapeutic use being exhaustively studied and researched, it stands as an invaluable asset in the biomedicine realm. Synonyms: P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 85065-24-3. Molecular formula: C20H26N10O13P2 (free acid). Mole weight: 676.43 (free acid). | |
| AP2Ribavirin | AP2Ribavirin, an antiviral drug, exerts its efficacy against the Hepatitis C virus (HCV) by curbing the replication of viral RNA through interference with RNA-dependent RNA polymerase. Coupled with other HCV drugs, AP2Ribavirin enhances therapeutic outcomes - serving as a frontline defense against this viral infection. Synonyms: 1,2,4-Triazole-3-carboxamide adenine dinucleotide, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H25N9O14P2 (free acid). Mole weight: 653.39 (free acid). | |
| AP39 | AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It is also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Grade: ≥95%. CAS No. 1429173-57-8. Molecular formula: C37H38O2PS3. Mole weight: 641.9. | |
| AP3A - lyophilized | AP3A - lyophilized is a biomedical product that holds immense value in understanding the complex aspects of liver-specific gene expression alongside the role of essential extracellular ATP. It has a proven track record in liver disease research and liver cancer. AP3A's profound potency lies in activating P2Y purinergic receptors, thus leading to a significant surge in ATP stimulation within liver cells. AP3A's ever-efficient lyophilized form guarantees long-term storage and easy usability for laboratory experiments. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 5959-90-0. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3A - solution | AP3A solution, a biochemical product entrenched in biomedical industry, commands center stage in studying purinergic signaling pathways, amongst others. This efficacious prodigy, a mainstay in academic research labs, abets multifarious research endeavors including, but not limited to, curing autoimmune disorders, neurodegenerative diseases, and cancer. AP3A solution, sourced from different research chemical providers, beckons an important armamentarium for scientists and researchers aiming to unearth the intricacies of cellular signaling pathways. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3G (A cap) | AP3G (A cap) is a non-functional cap analog used in the synthesis of mRNA to estimate the level of cap-independent translation. Synonyms: (ApppG); P1-(5'-Adenosyl) P3-(5'-guanosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27N10O17P3 (free acid). Mole weight: 772.41 (free acid). | |
| AP3 (Nic) | AP3 (Nic), a powerful and exclusive inhibitor of phosphodiesterase 10A (PDE10A), which has been extensively investigated for its probable therapeutic usage in motor and cognitive deficits observed in Parkinson's disease and schizophrenia, exhibits neurosignaling pathways modulation characteristics. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-Ribofuranosyl-nicotinamide)] triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C21H28N7O17P3 (free acid). Mole weight: 743.41 (free acid). | |
| AP4 | AP4 is a scientifically advanced compound, standing as an exemplary research for neurodegenerative ailments, including the formidable Parkinson's disease. With remarkable efficacy, it ensnares the unruly culprit, L-alpha-amino-4-hydroxy-2,3,5-trichlorobenzene (ATCB) which is an influential enzyme breaching dopamine's metabolic fortress. Synonyms: (Adenosine-5'-tetraphosphate); Adenosine-5'-tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 1062-98-2. Molecular formula: C10H17N5O16P4 (free acid). Mole weight: 587.16 (free acid). | |
| AP4 (8-Iodo-G) | AP4 (8-Iodo-G) is a chemical compound utilized in the biomedical industry for research purposes. Studies suggest that it may have applications in treating neurological disorders such as epilepsy, as well as potential antitumor and antimicrobial effects. Further research is ongoing to determine its full therapeutic potential. Synonyms: (AP4(8I-G)); P1-(5'-Adenosyl) P4-[5'-(8-iodo)-guanosyl] tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27IN10O20P4 (free acid). Mole weight: 978.28 (free acid). | |
| AP4A | AP4A is a signal molecule for DNA replication in mammalian cells. AP4A is used as a primer for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. AP4A is an inhibitor of eosinophil-derived neurotoxin (EDN). Uses: Ap4a is an inhibitor of eosinophil-derived neurotoxin (edn). Synonyms: (AppppA); P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 5542-28-9. Molecular formula: C20H28N10O19P4 (free acid). Mole weight: 836.39 (free acid). | |
| Ap4C | Ap4C, a nucleotide analogue, boasts the extraordinary capability of selectively activating purinergic receptor P2X receptors. Its potential applications are broad-spanning from treating inflammatory diseases to chronic pain and cancer, all of which are associated with abnormal purinergic signaling. Synonyms: P1- (5'- Adenosyl)- P4- (5'- cytidyl)- tetraphosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 1352921-13-1. Molecular formula: C19H28N8O20P4 (free acid). Mole weight: 812.4 (free acid). | |
| AP4dT | AP4dT is a novel and auspicious antiviral drug exhibiting compelling efficacy against HCV by suppressing viral RNA polymerase enzyme, thereby restraining viral genome replication. Preclinical studies suggest that AP4dT could be a potential pan-genotypic therapeutic candidate for HCV, capable of treating both genotype 1 and 3 infections alike. Synonyms: P1-(5'-Adenosyl) P4-[5'-(2'-deoxy-thymidyl)] tetraphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 13457-68-6. Molecular formula: C20H29N7O20P4 (free acid). Mole weight: 811.38 (free acid). | |
| AP4G | AP4G is a state-of-the-art biomedical compound meticulously used for studying an array of formidable neurological afflictions such as Alzheimer's, Parkinson's and epilepsy. Synonyms: (AppppG); P1-(5'-Adenosyl) P4-(5'-guanosyl) tetraphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 10527-46-5. Molecular formula: C20H28N10O20P4 (free acid). Mole weight: 852.39 (free acid). | |
| AP4U | AP4U, an innovative biomedical intervention, revolutionizes the therapeutic landscape in Parkinson's disease management. With extraordinary efficacy, this groundbreaking product exerts a profound influence on pyridoxal kinase, effectively curbing the transformation of pyridoxal into pyridoxal 5'-phosphate. Through this intricate modulation, AP4U remarkably ameliorates the debilitating symptoms of Parkinson's, presenting itself as an indispensable therapeutic remedy. Synonyms: P1-(5'-Adenosyl) P4-(5'-uridyl) tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 10527-48-7. Molecular formula: C19H27N7O21P4 (free acid). Mole weight: 813.35 (free acid). | |
| AP5 | AP5 is a potent and selective GPR40 receptor agonist (EC50 = 0.49±0.28 nM for rat hIP1) with positive allosteric modulation of endogenous ligands (AgoPAM). Synonyms: 2H-1-Benzopyran-7-propanoic acid, β-cyclopropyl-2-[2-fluoro-4-(2-methoxy-4-pyridinyl)phenyl]-3,4-dihydro-α-methyl-, (αS,βR,2S)-. Grade: ≥95%. CAS No. 1623194-37-5. Molecular formula: C28H28FNO4. Mole weight: 461.52. | |
| AP521 | AP521 is an agonist of human 5-HT1A receptor potentially for the treatment of anxiety. Synonyms: AP-521. CAS No. 151227-08-6. Molecular formula: C20H19ClN2O3S. Mole weight: 402.89. | |
| AP5 (8-Iodo-G) | AP5 (8-Iodo-G) is a highly potent biomedical compound, diligently functioning as a discriminating antagonist specifically modulating the AMPA receptor, thereby efficaciously facilitating the exploration and innovation of novel therapeutic modalities directed towards debilitating ailments. Synonyms: (AP5(8I-G)); P1-(5'-Adenosyl) P5-[5'-(8-iodo)-guanosyl] pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H28IN10O23P5 (free acid). Mole weight: 1058.26 (free acid). | |
| AP5A | AP5A is an adenosine A2A receptor antagonist used for studying Parkinson's disease. Uses: Vasoconstrictor agents. Synonyms: P1-(5'-Adenosyl) P5-(5'-adenosyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 41708-91-2. Molecular formula: C20H29N10O22P5 (free acid). Mole weight: 916.37 (free acid). | |
| AP5dT | AP5dT is an exceptional synthetic nucleoside analog, facilitating the exploration of intricate DNA replication and repair mechanisms. aP5dT can amplify the comprehension of virally-inflicted ailments (e.g., HIV, herpes) as well as diverse DNA-centric maladies. Synonyms: P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 103137-88-8. Molecular formula: C20H30N7O23P5 (free acid). Mole weight: 891.36 (free acid). | |
| AP5G | AP5G, a peptide analog, stands as a beacon of hope in the biomedical research realm, wielding its anti-tumor and anti-inflammatory properties. Heralding the growth and proliferation inhibition of cancer cells, especially those found in breast and lung cancer, AP5G adds another feather to its cap as an exquisitely effective anti-inflammatory agent, bestowing it with the ability to be contemplated as a potential panacea for maladies like rheumatoid arthritis and inflammatory bowel disease. Further, the possibility of assimilating AP5G into neurological disorder treatment regimes represents its multifaceted nuance, with exhaustive studies indicating its potential neuroprotective effects, making it a potential cog in the wheel to combat Alzheimer's disease. Synonyms: P1-(5'-Adenosyl) P5-(5'-guanosyl) pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-24-5. Molecular formula: C20H29N10O23P5 (free acid). Mole weight: 932.37 (free acid). | |
| AP5U | AP5U, a potent and selective inhibitor of phosphodiesterase-5 (PDE5), has emerged as a viable therapeutic intervention for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). This synthetic molecule relaxes the smooth muscles lining blood vessels, augmenting blood perfusion to the penile or pulmonary vasculature, and enhancing exercise capacity in PAH patients. AP5U promises to offer a ray of hope for those suffering from these debilitating health disorders, revolutionizing the way we perceive and treat ED and PAH in contemporary medicine. Synonyms: P1-(5'-Adenosyl) P5-(5'-uridyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-25-6. Molecular formula: C19H28N7O24P5 (free acid). Mole weight: 893.33 (free acid). | |
| AP6A | AP6A is a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate; Diadenosine hexaphosphate; P1,P6-di(Adenosine-5')hexaphosphate; Diadenosine 5',5''''-P1,P6-hexaphosphate; AppppppA; Ap(6)A; Adenosine-(5')-hexaphospho-(5')-adenosine; Adenosine 5'-hexaphosphate 5'-ester with adenosine; P1,P6-Bis(5'-adenosyl)hexaphosphate. Grade: ≥95% by HPLC. CAS No. 56983-23-4. Molecular formula: C20H30N10O25P6. Mole weight: 996.35. | |
| AP6A Sodium salt | AP6A Sodium salt is the salt of AP6A, a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate Sodium salt; Diadenosine hexaphosphate Sodium salt; P1,P6-di(Adenosine-5')hexaphosphate Sodium salt; Diadenosine 5',5''''-P1,P6-hexaphosphate Sodium salt; AppppppA Sodium salt; Ap(6)A Sodium salt; Adenosine-(5')-hexaphospho-(5')-adenosine Sodium salt; Adenosine 5'-hexaphosphate 5'-ester with adenosine Sodium salt; P1,P6-Bis(5'-adenosyl)hexaphosphate Sodium salt. Grade: ≥95% by HPLC. Molecular formula: C20H30N10O25P6 (free acid). Mole weight: 996.35 (free acid). | |
| ApA | ApA is a nucleoside derivative prevalent in the biomedical sector, garnering significant attention due to its profound implications in research of viral infections. Synonyms: RNA Dinucleotide (5'→3'), Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H25N10O10P (free acid). Mole weight: 596.45 (free acid). | |
| APA Amoxicillin Amide | APA Amoxicillin Amide is a derivative of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: N-(Penicillan-6-yl) amoxicillinamide; Amoxicillin EP Impurity L; Amoxicillin USP Related Compound L; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimeth yl-7-oxo-, (2S,5R,6R)-. Grade: 95%. CAS No. 1789703-32-7. Molecular formula: C24H29N5O7S2. Mole weight: 563.65. | |
| Apadenoson | An A2A adenosine receptor agonist. Adjunct to nuclear myocardial perfusion imaging in patients unable to exercise adequately. Synonyms: trans-4-[3-[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 250386-15-3. Molecular formula: C23H30N6O6. Mole weight: 486.53. | |
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