BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Apadenoson-d5 | Apadenoson-d5 is a labelled A3A adenosine receptor agonist. Synonyms: trans-4-[3-[6-Amino-9-[N-(ethyl-d5)-β-D-ribofuranuronamidosyl)]-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. Molecular formula: C23H25N6O6D5. Mole weight: 491.56. |  |
| Apadoline | Apadoline is a third-generation topical retinoid used for the topical treatment of acne vulgaris. Adapalene binds to retinoic acid receptor (RAR)-beta and RAR-gamma; this complex subsequently binds to one of three retinoid X receptors (RXRs), which as a complex is capable of binding DNA to modulate transcriptional activity. Grade: 98% by HPLC. CAS No. 135003-30-4. Molecular formula: C23H29N3OS. Mole weight: 395.6. | |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Synonyms: ARN-509; Apalutamide; ARN 509; JNJ56021927; JNJ-56021927; JNJ 56021927; ARN509. Grade: 98%. CAS No. 956104-40-8. Molecular formula: C21H15F4N5O2S. Mole weight: 477.43. | |
| Apalutamide Dithio Impurity | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-6,8-dithioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide; Apalutamide Impurity 27; Apalutamide Disulphur impurity. Grade: ≥95%. CAS No. 2649802-40-2. Molecular formula: C21H15F4N5OS2. Mole weight: 493.50. | |
| Apalutamide Impurity 3 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[[1-[[6-cyano-5-(trifluoromethyl)-3-pyridyl]carbamoyl]cyclobutyl]amino]-2-fluoro- N-methyl-benzamide. Grade: 95%. CAS No. 1950587-20-8. Molecular formula: C20H17F4N5O2. Mole weight: 435.37. | |
| Apalutamide Impurity 4 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide Di-(2-fluoro-N-methylbenzamide); 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Grade: 95%. CAS No. 2894796-76-8. Molecular formula: C29H21F5N6O3S. Mole weight: 628.58. | |
| Apalutamide metabolite M4 | Apalutamide metabolite M4 is a metabolite of Apalutamide, which is an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide-COOH; Apalutamide Acid Impurity; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid. CAS No. 1332391-04-4. Molecular formula: C20H12F4N4O3S. Mole weight: 464.39. | |
| Apatinib | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Synonyms: Rivoceranib; YN968D1. Grade: 98%. CAS No. 811803-05-1. Molecular formula: C24H23N5O. Mole weight: 397.48. | |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Synonyms: YN968D1. Grade: >98%. CAS No. 1218779-75-9. Molecular formula: C25H27N5O4S. Mole weight: 493.58. | |
| Apaziquone | Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. Synonyms: 1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)-; APAZIQUONE. CAS No. 141304-51-0. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| APC-100 | APC-100 is an orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells. Uses: Antioxidants. Synonyms: 2,2,5,7,8-Pentamethyl-6-chromanol; Chromanol; 6-Hydroxy-2,2,5,7,8-pentamethylchroman; APC100; 3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-Benzopyran-6-ol. Grade: 98%. CAS No. 950-99-2. Molecular formula: C14H20O2. Mole weight: 220.312. | |
| APC-366 hydrochloride | APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM. Synonyms: APC 366; APC 366; APC 366; AC1L42OR; N-(1-Hydroxy-2-naphthoyl)-L-arginine-L-prolinamide; 158921-85-8. Grade: 98%. CAS No. 178925-65-0. Molecular formula: C22H29ClN6O4. Mole weight: 477. | |
| APC 366 trifluoroacetate salt | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grade: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
| AP C5 | AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor with pIC50 of 7.2, which displays >20-fold selectivity for PKG2 over PKG1 and PKA. Synonyms: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine; AP-C5; APC5. Grade: ≥98%. CAS No. 2234272-10-5. Molecular formula: C16H13N5. Mole weight: 275.31. | |
| APC-6336 | APC-6336 is a Hepatitis C virus NS3 protein inhibitor. Synonyms: (2R)-2-[[2-[(6-carbamoyl-1H-benzimidazol-2-yl)methyl]-3-methylbenzimidazole-5-carbonyl]amino]-3-phosphonopropanoic acid; APC-6336; APC 6336; APC6336; UNII-4124YUO44Z; CRA-6336; 4124YUO44Z. Grade: >98%. CAS No. 263870-19-5. Molecular formula: C21H21N6O7P. Mole weight: 500.4. | |
| Apcin | Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grade: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65. | |
| Apcin-A | Apcin-A is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Synonyms: Apcin-A; 1683617-62-0; 3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate; starbld0000888; SCHEMBL22567019; EX-A5236; AKOS030257613; MS-25252; HY-130841; CS-0114386. CAS No. 1683617-62-0. Molecular formula: C10H14Cl3N5O2. Mole weight: 342.61. | |
| APcK110 | KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer. Synonyms: APcK 110; APcK-110; 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine. Grade: >98%. CAS No. 1001083-74-4. Molecular formula: C34H49N5O6. Mole weight: 349.36. | |
| ApCp | ApCp, an avant-garde and unprecedented compound, used for studying an array of ailments, encompassing malignant neoplasms and immune-mediated disorders. Uses: Enzyme inhibitors. Synonyms: Adenosine, 5'-[hydrogen P-(phosphonomethyl)phosphonate]; Adenosine, 5'-(trihydrogen methylenediphosphonate); Adenosine, 5'-[hydrogen (phosphonomethyl)phosphonate]; Adenosine, 5'-methylenediphosphonate; α,β-Methylene adenosine 5'-diphosphate; α,β-Methylene-ADP; α,β-Methylene adenosine diphosphate; Adenosine α,β-methylenediphosphate; α,β-Methylene-5'-ADP; Adenosine 5'-(α,β-methylene)diphosphate; MethADP; AMPCP; 5'-Adenylyl methylenephosphonate. Grade: ≥ 95% by HPLC. CAS No. 3768-14-7. Molecular formula: C11H17N5O9P2. Mole weight: 425.23. | |
| APCP-363 | APCP-363 a bio-active chemical. Uses: Apcp-363 a bio-active chemical. Synonyms: CP-363; CP 363; CP363; APCP-363; APO-363; APCP 363; APO 363; APCP363; APO363; UNII-N1969I6FAP. 3-hydroxy-2-(1-methoxyethyl)-1,6-dimethylpyridin-4-one. Grade: ≥98%. CAS No. 340023-40-7. Molecular formula: C10H15NO3. Mole weight: 197.23. | |
| ApCpp | ApCpp is a highly intriguing and intricate biochemical compound with multifaceted role as a substrate for diverse enzymes. It has promising applications in research of ailments such as cancer, neurodegenerative disorders and metabolic syndromes of varied etiologies. Synonyms: (AMPCPP); Adenosine-5'-[(α,β)-methyleno]triphosphate, Sodium salt; α,β-Methyleneadenosine-5'-triphosphate. Grade: ≥ 98% by HPLC. CAS No. 7292-42-4. Molecular formula: C11H18N5O12P3 (free acid). Mole weight: 505.21 (free acid). | |
| ApCpp (Nic) | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920; 2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grade: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
| APD597 (JNJ-38431055) | APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo. Synonyms: APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055. Grade: 98%. CAS No. 897732-93-3. Molecular formula: C21H29N5O6S. Mole weight: 479.55. | |
| APD668 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Synonyms: APD668; APD-668; APD 668; JNJ28630368; JNJ-28630368; JNJ 28630368. Grade: 0.99. CAS No. 832714-46-2. Molecular formula: C21H24FN5O5S. Mole weight: 477.511. | |
| AP-dC-CE Phosphoramidite | AP-dC-CE Phosphoramidite is an invaluable reagent utilized within the fascinating realm of medicinal chemistry for synthesizing oligonucleotide prodrugs with great precision. This remarkable compound is frequently employed within cutting-edge drug design, enabling the targeted delivery of therapeutic agents to specific cells or tissues - a fundamental approach for treating an array of diseases ranging from cancer and viral infections to complex genetic disorders. Synonyms: 1-[5'-O-(4,4'-Dimethoxytrityl)-β-D-2'-deoxyribofuranosyl]-9-(2-trifluoroacetamidoethoxy)-1,3-diaza-2-oxophenoxazine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite. Molecular formula: C49H54F3N6O10P. Mole weight: 974.97. | |
| AP-dC Phosphoramidite | AP-dC Phosphoramidite is a modified cytidine phosphoramidite used in oligonucleotide synthesis. AP stands for an abasic protection group on the cytosine base, which means the standard cytosine base is absent or replaced with a protecting group, creating an abasic site. This modification is typically used in studies involving DNA damage, repair mechanisms, or the creation of oligonucleotides with specific lesions for biochemical and biophysical analyses. The phosphoramidite group at the 3' position enables its incorporation into oligonucleotide chains during solid-phase synthesis. AP-dC Phosphoramidite is valuable for generating site-specific abasic modifications in DNA to investigate structural and functional aspects of nucleic acids. Synonyms: N-[2-[[3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-2,3-dihydro-2-oxo-1H-pyrimido[5,4-b][1,4]benzoxazin-9-yl]oxy]ethyl]-2,2,2-trifluoroacetamide; DNA C-clamp (TFA); 1-[5'-O-(4,4'-Dimethoxytrityl)-β-D-2'-deoxyribofuranosyl]-9-(2-trifluoroacetamidoethoxy)-1,3-diaza-2-oxophenoxazine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; AP-dC-CE Phosphoramidite. Grade: ≥97%. CAS No. 1360536-91-9. Molecular formula: C49H54F3N6O10P. Mole weight: 974.96. | |
| APE1 Inhibitor III | APE1 Inhibitor III is a selective and competitive inhibitor of apurinic/apyrimidinic (AP) endonuclease 1 (APE1) with 2.0 micromolar activity against the purified APE1 enzyme. Synonyms: N-[3-(1,3-Benzothiazol-2-yl)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]acetamide. Grade: 99%. CAS No. 524708-03-0. Molecular formula: C19H21N3OS2. Mole weight: 371.52. | |
| Apelin-12 acetate | Apelin-12 induces calcium mobilization in APJ-Gαq16 cells expressing human APJ and inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells. Apelin-12 inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. Synonyms: Preproapelin (66-77) (human, bovine, mouse, rat) acetate; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat) acetate; Apelin Precursor (66-77) (human, bovine, mouse, rat) acetate. Molecular formula: C66H107N21O16S. Mole weight: 1482.77. | |
| Apelin-13 trifluoroacetate salt | Apelin-13 trifluoroacetate salt is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Synonyms: Apelin-13 triTFA. Molecular formula: C75H114F9N23O22S. Mole weight: 1892.89. | |
| Apelin-17 (human, bovine) acetate | Apelin-17 (human, bovine) acetate, secreted by adipocytes, is an endogenous ligand of the G protein-coupled APJ receptor with an EC50 of 2.5 nM. It is an endogenous apelin receptor agonist that potently inhibits forskolin-stimulated cAMP production in vitro. Synonyms: H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH.CH3CO2H; L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine acetic acid. Grade: ≥95%. Molecular formula: C98H160N34O22S. Mole weight: 2198.63. | |
| APF Sialoglycopeptide ammonium salt | APF Sialoglycopeptide ammonium salt is a cutting-edge biomedical compound, demonstrating remarkable capabilities in research of dental caries. Proven to possess potent antimicrobial properties against the notorious Streptococcus mutans, this compound also exhibits an extraordinary affinity for hydroxyapatite, amplifying the process of tooth remineralization. Synonyms: O-(Acetamido-3,5-dideoxy-D-glycero-a-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-b-D- galactopyranosyl-(1→3)-O-a-2-acetamido-2-deoxy-D-galactopyranosyl-(1 →O)- Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala; NeuNAc-a(2→3)-Gal-b(1→3)-GalNAc-a-Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala. Molecular formula: C63H107N11O29. Mole weight: 1482.58. | |
| ApG | ApG is a scientifically advanced compound, specifically designed to study inflammatory skin disorders as well as combat skin infections. It comprises a potent blend of bioactive drugs exhibiting exceptional antimicrobial and anti-inflammatory attributes. Grade: ≥ 95% by HPLC. Molecular formula: C20H25N10O11P (free acid). Mole weight: 612.14 (free acid). | |
| APG-1387 | APG-1387 is an inhibitor of IAPs. Study shows that APG-1387 could induce apoptosis of PLC/PRF/5 which was HBV positive both in vitro and in vivo. Synonyms: APG 1387; APG1387. Grade: 98% by HPLC. CAS No. 1570231-89-8. Molecular formula: C60H72N10O10S2. Mole weight: 1157.4. | |
| APHA Compound 8 | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grade: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
| API-1 | Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growt h arrest and apoptosis in human cancer cells expressing constitutively active Akt. Synonyms: API 1; API1; NSC177233; NSC 177233; NSC-177233; 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(beta-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide. Grade: >98%. CAS No. 36707-00-3. Molecular formula: C28H30FN5O2. Mole weight: 337.29. | |
| Apigenin 4'-β-D-glucuronide Triacetate Methyl Ester | Apigenin 4'-β-D-glucuronide Triacetate Methyl Ester is an intermediate in synthesizing Isorhoifolin, a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects. Synonyms: Apigenin 4'-β-D-Gucopyranoside Triacetate Methyl Ester. Molecular formula: C28H28O14. Mole weight: 588.51. | |
| Apigenin 7-β-D-glucuronide Triacetate Methyl Ester | Apigenin 7-β-D-glucuronide Triacetate Methyl Ester is an intermediate in synthesizing Isorhoifolin, a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects. Synonyms: Apigenin 7-β-D-Gucopyranoside Triacetate Methyl Ester. Molecular formula: C28H28O14. Mole weight: 588.51. | |
| AP-III-a4 | AP-III-a4 is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 μM); inhibit cancer cell metastasis in vivo. Synonyms: ENOblock. Grade: >98%. CAS No. 1177827-73-4. Molecular formula: C31H43FN8O3. Mole weight: 594.72. | |
| Apilimod | Apilimod is a potent and orally bioavailable inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases by inhibition of IL-12 and IL-23 production. Synonyms: STA-5326; STA 5326; STA5326; N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine. Grade: 99%. CAS No. 541550-19-0. Molecular formula: C23H26N6O2. Mole weight: 418.49. | |
| Apilimod mesylate | The mesylate salt form of Apilimod. Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases by inhibition of IL-12 and IL-23 production. Synonyms: methanesulfonic acid N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine. Grade: 98%. CAS No. 870087-36-8. Molecular formula: C23H26N6O2.2CH4O3S. Mole weight: 610.7. | |
| Apimostinel | Apimostinel is a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex under investigation by Naurex. Its mechanism of action and effects are similar to those of rapastinel. But Apimostinel is 100-fold more potent by weight and, unlike rapastinel (which must be administered via intravenous injection), is orally-active. Phase II clinical trials for the treatment of Major depressive disorder is on-going. Uses: Major depressive disorder. Synonyms: NRX-1074; NRX 1074; NRX1074; AGN-241660; AGN241660; AGN 241660. Apimostinel; (2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide. Grade: 98%. CAS No. 1421866-48-9. Molecular formula: C25H37N5O6. Mole weight: 503.60. | |
| APIO-EE-07 | APIO-EE-07 is a dual-target inhibitor of RSK1 and MSK2. It was shown to suppress colon cancer cell growth and anchorage-independent growth. Synonyms: 5-Fluoro-3-(4-(4-nitrophenyl)-2-oxobut-3-enylidene)indolin-2-one. Grade: 98%. CAS No. 1606160-46-6. Molecular formula: C18H11FN2O4. Mole weight: 338.29. | |
| Apiogalacturonan | Apiogalacturonan is a pectin found in the walls of Lemna and Zostera marina. Apiogalacturonan, depicted as a remarkable bioactive polysaccharide deeply rooted in the plant kingdom, showcasing immense promise application in studying diverse ailments such as malignancies, diabetes and cardiovascular afflictions. Synonyms: Galacturonoapian. CAS No. 9039-3-6. | |
| Apitolisib | Apitolisib, also known as GDC-0980 and RG7422; or GNE390, is a dual PI3 kinase/mTOR inhibitor, is also an orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor GDC-0980 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion. Synonyms: GDC-0980; GDC0980; GDC 0980; RG7422; RG-7422; RG 7422; GNE 390; GNE390; GNE-390; Apitolisib. CAS No. 1032754-93-0. Molecular formula: C23H30N8O3S. Mole weight: 498.606. | |
| Apixaban | Apixaban (INN, trade name Eliquis) is an anticoagulant for the prevention of venous thromboembolism and the prevention of stroke in atrial fibrillation. It is a direct factor Xa inhibitor. Apixaban has been available in Europe since May 2011. The drug was developed in a joint venture by Pfizer and Bristol-Myers Squibb. Uses: Factor xa inhibitors. Synonyms: BMS-562247-01; BMS 562247-01; BMS562247-01; brand name: Eliquis. Grade: 0.98. CAS No. 503612-47-3. Molecular formula: C25H25N5O4. Mole weight: 459.506. | |
| Apixaban Acid | A metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid; Apixaban Impurity 41. CAS No. 503614-92-4. Molecular formula: C25H24N4O5. Mole weight: 460.5. | |
| Apixaban Amine Amide Impurity | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; Apixaban Impurity 17. CAS No. 1423803-24-0. Molecular formula: C20H19N5O3. Mole weight: 377.40. | |
| Apixaban Amino Acid Impurity | It is an open ring impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: Apixaban open ring acid; Apixaban Open Chain Acid; 5-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic acid. CAS No. 2206825-87-6. Molecular formula: C25H27N5O5. Mole weight: 477.51. | |
| Apixaban Dehydro Impurity | A metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: 4,5-Dehydro Apixaban; 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-6,7-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 6,7-Dihydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-Pyrazolo[3,4-c]pyridine-3-carboxamide. Grade: > 95%. CAS No. 1074549-89-5. Molecular formula: C25H23N5O4. Mole weight: 457.49. | |
| Apixaban Impurity 14 | A metabolite of Apixaban. Synonyms: 6-(4-Aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid. Grade: > 95%. CAS No. 1704504-93-7. Molecular formula: C20H18N4O4. Mole weight: 378.39. | |
| Apixaban Impurity 15 | A metabolite of Apixaban. Synonyms: 6-(4-Aminophenyl)-4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 1466571-07-2. Molecular formula: C21H20N4O4. Mole weight: 392.42. | |
| Apixaban Impurity 31 | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: Apixaban methyl ester and cyclic amide open chain methyl ester. CAS No. 2458079-10-0. Molecular formula: C27H30N4O6. Mole weight: 506.56. | |
| Apixaban Impurity 46 | An impurity of Apixaban, which is a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: 3-chloro-1-(2-nitrophenyl)-1,2,5,6-tetrahydropyridin-2-one; 3-Chloro-1-(2-nitrophenyl)-5,6-dihydropyridin-2(1H)-one; Apixaban Related Compound 5. Grade: 95%. CAS No. 2219376-48-2. Molecular formula: C11H9ClN2O3. Mole weight: 252.65. | |
| Apixaban Impurity 6 | A metabolite of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: Apixaban Acid Methyl Ester. Grade: > 95%. CAS No. 1074365-84-6. Molecular formula: C26H26N4O5. Mole weight: 474.52. | |
| Apixaban Impurity 9 | A metabolite of Apixaban. Synonyms: Apixaban V; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid Ethyl Ester Ethyl 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyri. Grade: > 95%. CAS No. 503614-91-3. Molecular formula: C27H28N4O5. Mole weight: 488.55. | |
| Apixaban Nitro Acid Impurity | An impurity of Apixaban, a direct factor Xa inhibitor used as an anticoagulant for the prevention of venous thromboembolism and stroke in atrial fibrillation. Synonyms: 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid. Molecular formula: C20H16N4O6. Mole weight: 408.37. | |
| Apixaban Related Compound 1 | A metabolite of Apixaban. Synonyms: Ethyl (2E)-2-[(4-methoxyphenyl)hydrazono]propanoate. Grade: > 95%. CAS No. 4792-57-8. Molecular formula: C12H16N2O3. Mole weight: 236.27. | |
| Apixaban Related Compound 2 | A metabolite of Apixaban. Synonyms: 3-chloro-1-(4-methoxyphenyl)-5,6-dihydropyridin-2(1H)-one. Grade: > 95%. CAS No. 536760-29-9. Molecular formula: C11H9ClN2O3. Mole weight: 252.66. | |
| Apixaban Related Compound 3 | A metabolite of Apixaban. Synonyms: 5-chloro-4-methylpentanoyl chloride. Grade: > 95%. CAS No. 813452-05-0. Molecular formula: C6H10Cl2O. Mole weight: 169.05. | |
| Apixaban Related Compound 4 | A metabolite of Apixaban. Synonyms: 5-Chloro-hexanoyl Chloride. Grade: > 95%. CAS No. 99585-01-0. Molecular formula: C6H10Cl2O. Mole weight: 169.05. | |
| Aplaviroc | Aplaviroc is a potent non-competitive CCR5 receptor allosteric antagonist with IC50 of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Uses: Hiv fusion inhibitors. Synonyms: AK 602. Grade: 98%. CAS No. 461443-59-4. Molecular formula: C33H43N3O6. Mole weight: 577.7. | |
| Aplindore Fumarate | Aplindore Fumarate is a partial agonist selective for the dopamine receptor D2 used in the therapeutic treatment of Parkinson Disease and restless legs syndrome. Synonyms: (2S)-2-[(benzylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-8-one; (E)-but-2-enedioic acid; (S)-2-(benzylamino-methyl)-2,3,8,9-tetrahydro-7H-1,4-dioxino(2,3-e)indol-8-one fumarate; aplindore fumarate; 189681-70-7(Aplindore free base); DAB-452; DAB 452; DAB452. Grade: >98%. CAS No. 189681-71-8. Molecular formula: C22H22N2O7. Mole weight: 426.42. | |
| APN/AKT-IN-1 | APN/AKT-IN-1 is a potent and dual inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. APN/AKT-IN-1 can effectively inhibit the phosphorylation of GSK3β, the intracellular substrate of AKT. Synonyms: APN/AKT-IN-1; CHEMBL5028482; HY-145244; CS-0370284. Molecular formula: C18H27N7O3. Mole weight: 389.45. | |
| ApNHpp | ApNHpp is a biomedical compound hindering adenosine 5'-monophosphate-activated protein kinase (AMPK), a key orchestrator in the intricate symphony of energy equilibrium and metabolism. Synonyms: (AMPNPP); Adenosine-5'-[(α,β)-imido]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 114635-42-6. Molecular formula: C10H17N6O12P3 (free acid). Mole weight: 506.20 (free acid). | |
| Apoatropine | Apoatropine is an alkaloid derivative with the potential to be an antibacterial. Synonyms: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, atropate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl atropate; alpha-methylene-benzeneaceticaci8-methyl-8-azabicyclo(3.2.1)oct-3-yles. Grade: > 95%. CAS No. 500-55-0. Molecular formula: C17H21NO2. Mole weight: 271.36. | |
| apoatropine hydrochloride | Apoatropine is an alkaloid derivative with the potential to be an antibacterial. Synonyms: Apoatropine HCl. CAS No. 5978-81-4. Molecular formula: C17H22ClNO2. Mole weight: 307.82. | |
| Apo-Enopeptin methyl ester | Apo-enopeptin methyl ester is a derivative of enopeptin A. Grade: >95% by HPLC. Molecular formula: C48H61N7O12. Mole weight: 928.03. | |
| APOL1-IN-1 | APOL1-IN-1 is an inhibitor of apolipoprotein L1 (APOL1), a minor apoprotein component of HDL cholesterol. CAS No. 2446817-72-5. Molecular formula: C21H20FN3O3. Mole weight: 381.4. | |
| Apolizumab | Apolizumab is a humanized monoclonal antibody developed for the treatment of hematologic cancers. Synonyms: Hu1D10. Grade: 95%. CAS No. 267227-08-7. | |
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