BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AT7867 dihydrochloride | AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μM and 3.04 μM, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145 cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK-3β in human tumor cells with IC50 of 2-4 μM. AT7867 also induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells. AT7867 shows bioavailability of 44% in mice by p.o. route. AT7867 could increase the cleaved PARP in MES-SA xenografts at 20 mg/kg i.p. or 90 mg/kg p.o. AT7867 significantly inhibits the tumor growth in MES-SA xenografts or U87MG xenografts with T/C of 0.37 and 0.51, respectively. Synonyms: AT-7867 dihydrochloride; AT 7867 dihydrochloride. Grade: >98%. CAS No. 1431697-86-7. Molecular formula: C20H22Cl3N3. Mole weight: 410.77. |  |
| AT-9010 | AT-9010 is a potent inhibitor of NiRAN which is a function essential for viral replication. AT-9010 can inhibit SARS-CoV-2 replication. Synonyms: (2'R)-2'-Deoxy-2'-fluoro-2'-methylguanosine 5'-(tetrahydrogen triphosphate). Grade: >98%. CAS No. 1261253-79-5. Molecular formula: C11H17FN5O13P3. Mole weight: 539.20. | |
| AT-9010 tetrasodium | AT-9010 tetrasodium can inhibit SARS-CoV-2 replication. Synonyms: AT-9010. Grade: ≥98% by HPLC. CAS No. 1621884-18-1. Molecular formula: C11H13FN5Na4O13P3. Mole weight: 627.13. | |
| AT-9010 triethylamine | The active triphosphate metabolite AT-9010 can inhibit SARS-CoV-2 replication. Synonyms: UNII-IR49Q7E87C triethylamine. Grade: ≥98% (HPLC). CAS No. 2648089-95-4. Molecular formula: C35H77FN9O13P3. Mole weight: 943.96. | |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Synonyms: AT9283; AT 9283; AT-9283. Grade:>98%. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.43. | |
| AT-9283 L-lactate | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Synonyms: AT 9283; AT9283. CAS No. 896466-76-5. Molecular formula: C19H23N7O2. Mole weight: 471.52. | |
| Ataciguat | Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, is a potent guanylate cyclase activator. Ataciguat has potential to treat diseases associated with increased vascular tone combined with enhanced ROS production. Uses: Ataciguat, formerly referred to as hmr-1766, a novel anthranilic acid derivative, belongs to a new structural class of sgc activators capable of activating the oxidized form of sgc. ataciguat has been shown to improve endothelial function and to reduce p. Synonyms: HMR-1766; HMR 1766; HMR1766; Ataciguat; 5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; Ataciguat; HMR 1766. Grade: >98%. CAS No. 254877-67-3. Molecular formula: C21H19Cl2N3O6S3. Mole weight: 576.5. | |
| Atagabalin | Atagabalin, also referred to PD-0200,390, is a gabamimetic agent developed as a treatment for insomnia but was discontinued following unsatisfactory trial results. Synonyms: 2-[(3S,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid; (1-aminomethyl-3,4-dimethylcyclopentyl)acetic acid; PD 0200390; PD-0200390; PD0200390. Grade: >98%. CAS No. 223445-75-8. Molecular formula: C10H19NO2. Mole weight: 185.267. | |
| Ataluren | Ataluren is an investigational new drug designed to enable the formation of a functioning protein in patients with genetic disorders due to a nonsense mutation. Ataluren is currently being investigated for use in patients with nonsense mutation Duchenne/Becker muscular dystrophy (nmDBMD) and cystic fibrosis (nmCF). Synonyms: PTC124; PTC-124; PTC 124. Grade: 0.98. CAS No. 775304-57-9. Molecular formula: C15H9FN2O3. Mole weight: 284.246. | |
| Atamestane | Atamestane is a synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Uses: Enzyme inhibitors. Synonyms: Atamestanum; Atamestano; Biomed-777; Biomed 777; Biomed777; CCRIS 6528; CCRIS6528; CCRIS-6528; SH-489; SH 489; SH489. CAS No. 96301-34-7. Molecular formula: C20H26O2. Mole weight: 298.43. | |
| Ataquimast | Ataquimast is used in curing advanced receptor-positive breast cancer. Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells. Synonyms: 1-Ethyl-3-(methylamino) 2(1H)-quinoxalinone. CAS No. 182316-31-0. Molecular formula: C11H13N3O. Mole weight: 203.24. | |
| Atazanavir | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Synonyms: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. Grade: 0.98. CAS No. 198904-31-3. Molecular formula: C38H52N6O7. Mole weight: 704.869. | |
| Atazanavir Di-tert-butyl Analog | An impurity of Atazanavir. Synonyms: Des-N-(methoxycarbonyl)-L-tert-leucine Bis-Boc Atazanavir. Grade: > 95%. CAS No. 198904-86-8. Molecular formula: C32H42N4O5. Mole weight: 562.72. | |
| Atazanavir Hydrazine Analog Trihydrochloride | An intermediate for the synthesis of Atazanavir and the preparation of some peptide analogs. Synonyms: Des-N-(methoxycarbonyl)-L-tert-leucine Atazanavir Trihydrochloride. Grade: > 95%. CAS No. 198904-87-9. Molecular formula: C22H26N4O. 3 HCl. Mole weight: 362.48 3 36.46. | |
| Atazanavir Impurity 1 | An epimeric impurity of Atazanavir. Synonyms: (3S,8R,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-,2,5,6,10,13-pentaazatetradecanedioic Acid 1,14-Dimethyl Ester. Grade: > 95%. CAS No. 1292296-09-3. Molecular formula: C38H52N6O7. Mole weight: 704.87. | |
| Atazanavir Impurity 5 | An impurity of Atazanavir. Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme. Synonyms: 4-O-[4,6-O-[4-(pyridin-2-yl)benzylidene]-β-D-galactopyranosyl]-β-D-glucopyranoside. Grade: >95%. Molecular formula: C24H29NO11. Mole weight: 507.50. | |
| Atazanavir Impurity B | An impurity of Atazanavir. Synonyms: 1-Boc-2-[4-(2-pyridinyl)benzylidene]hydrazine. Grade: > 95%. CAS No. 198904-85-7. Molecular formula: C17H21N3O2. Mole weight: 299.38. | |
| Atazanavir related compound A | An impurity of Atazanavir. Synonyms: N-(Methoxycarbonyl)-L-tert-leucine. Grade: > 95%. CAS No. 162537-11-3. Molecular formula: C8H15NO4. Mole weight: 189.21. | |
| Atazanavir R,S,S,R-Diastereomer | An impurity of Atazanavir. Synonyms: (3R,8S,9S,12R)-Atazanavir. Grade: > 95%. CAS No. 1292296-11-7. Molecular formula: C38H52N6O7. Mole weight: 704.87. | |
| Atazanavir R,S,S,S-diastereomer | An impurity of Atazanavir. Synonyms: (3R,8S,9S,12S)-Atazanavir. Grade: > 95%. CAS No. 1332981-14-2. Molecular formula: C38H52N6O7. Mole weight: 704.87. | |
| Atazanavir S,S,R,S-Diastereomer | An impurity of Atazanavir. Synonyms: (3R,8R,9S,12R)-Atazanavir. Grade: > 95%. CAS No. 1292296-10-6. Molecular formula: C38H52N6O7. Mole weight: 704.87. | |
| Atazanavir S,S,S,R-diastereomer | An impurity of Atazanavir. Synonyms: (3S,8S,9S,12R)-Atazanavir. Grade: > 95%. CAS No. 1332981-16-4. Molecular formula: C38H52N6O7. Mole weight: 704.87. | |
| Atazanavir Sulfate | Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus. Uses: Hiv protease inhibitors. Synonyms: BMS-232632; BMS 232632; BMS232632; Reyataz. Grade: >98%. CAS No. 229975-97-7. Molecular formula: C38H52N6O7.H2SO4. Mole weight: 802.93. | |
| ATB107 hydrochloride | ATB107 hydrochloride is a hydrochloride form of ATB107 that inhibits indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM. Grade: >98.0%. Molecular formula: C21H29ClN8. Mole weight: 428.96. | |
| ATB 346 | ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. CAS No. 1226895-20-0. Molecular formula: C21H19NO3S. Mole weight: 365.447. | |
| ATC 0175 hydrochloride | The hydrochloride salt form of ATC 0175, which has been found to be a MCHR1, SR-1A and SR-2B inhibitor and probably show anxiolytic and antidepressant activities. Synonyms: ATC0175; ATC-0175; ATC 0175. N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 510733-97-8. Molecular formula: C23H25F2N5O.HCl. Mole weight: 461.94. | |
| Atenolol beta-D-Glucuronide | Atenolol beta-D-Glucuronide is an impurity of Atenolol, which is a cardioselective β-adrenergic blocker. Synonyms: Atenolol β-D-Glucuronide; (R,S)-Atenolol O-β-D-glucuronide. CAS No. 889359-84-6. Molecular formula: C20H30N2O9. Mole weight: 442.47. | |
| Atenolol EP Impurity A | Atenolol EP Impurity A is used as an intermediate for the synthesis of Atenolol, which is a β-blocker and used to treat hypertension, angina and arrhythmia. It is a process impurity for Atenolol. Synonyms: 4-Hydroxybenzeneacetamide; (p-Hydroxyphenyl)acetamide; 2-(4-Hydroxyphenyl)acetamide; p-(Carbamoylmethyl)phenol; Atenolol USP Related Compound A; Atenolol Related Compound A. Grade: > 95%. CAS No. 17194-82-0. Molecular formula: C8H9NO2. Mole weight: 151.16. | |
| Atenolol EP Impurity B | Atenolol EP Impurity B is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 4-(2,3-dihydroxypropoxy)phenyl acetamide; Benzeneacetamide, 4-(2,3-dihydroxypropoxy)-; Des(isopropylaMino) Atenolol Diol; Atenolol USP Related Compound B; Atenolol Related Compound B. Grade: > 95%. CAS No. 61698-76-8. Molecular formula: C11H15NO4. Mole weight: 225.24. | |
| Atenolol EP Impurity D | Atenolol EP Impurity D is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 2-[4-[(2RS)-3-Chloro-2-hydroxypropoxy]phenyl]acetamide; 4-(3-Chloro-2-hydroxypropoxy)benzeneacetamide. Grade: > 95%. CAS No. 115538-83-5. Molecular formula: C11H14ClNO3. Mole weight: 243.69. | |
| Atenolol EP Impurity E | Atenolol EP Impurity E is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: Atenolol USP Related Compound E; Atenolol Related Compound E; 4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide. Grade: > 95%. CAS No. 141650-31-9. Molecular formula: C19H22N2O5. Mole weight: 358.40. | |
| Atenolol EP Impurity F | Atenolol EP Impurity F is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 4,4'-[[(1-Methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide; 2,2'-(4,4'-(3,3'-(isopropylazanediyl)bis(2-hydroxypropane-3,1-diyl))bis(oxy)bis(4,1-phenylene))diacetamide; Atenolol USP Related Compound F; Atenolol Related Compound F. Grade: > 95%. CAS No. 87619-83-8. Molecular formula: C25H35N3O6. Mole weight: 473.57. | |
| Atenolol EP Impurity G | Atenolol EP Impurity G is the acidic inactive metabolite of Metoprolol and is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: Atenolol USP Related Compound G; Atenolol Related Compound G; Metoprolol Acid; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetic Acid; 4-(2-Hydroxy-3-isopropylaminopropoxy)phenylacetic Acid; 4-(3-Isopropylamino-2-hydroxypropoxy)benzeneacetic acid. Grade: > 95%. CAS No. 56392-14-4. Molecular formula: C14H21NO4. Mole weight: 267.33. | |
| Atenolol EP Impurity H | Atenolol EP Impurity H is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 2-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetonitrile; [p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetonitrile; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetonitrile; Atenolol related compound B. Grade: > 95%. CAS No. 29277-73-4. Molecular formula: C14H20N2O2. Mole weight: 248.33. | |
| Atenolol EP Impurity J | Atenolol EP Impurity J is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 4-(3-amino-2-hydroxypropoxy)phenylacetamide. CAS No. 81346-71-6. Molecular formula: C11H16N2O3. Mole weight: 224.26. | |
| Atenolol impurity C | Atenolol impurity C is an impurity of Atenolol, a cardioselective β-adrenergic blocker. Synonyms: 4-(Oxiranylmethoxy)benzeneacetamide; 2-(4-Oxiranylmethoxy-phenyl)-acetamide; 4-(2,3-Epoxypropoxy)phenylacetamide; 1,2,3,4-Tetrahydro-4-oxacarbazole; p-(2,3-Epoxypropyloxy)phenylacetamide. Grade: > 95%. CAS No. 29122-69-8. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| a-Tetrasaccharide-APE-KLH | a-Tetrasaccharide-APE-KLH. | |
| ATG7-IN-1 | ATG7-IN-1 is a potent and selective inhibitor of ATG7 with an IC50 of 62 nM. CAS No. 2226229-87-2. Molecular formula: C17H19FN6O5S2. Mole weight: 470.50. | |
| Atglistatin | Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM. Synonyms: Atglistatin; 1469924-27-3; 3-(4'-(Dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea; CHEMBL3823931; MFCD28009494; 3-[3-[4-(dimethylamino)phenyl]phenyl]-1,1-dimethylurea; 3-[4'-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea; 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea; 1-[4'-(DIMETHYLAMINO)-[1,1'-BIPHENYL]-3-YL]-3,3-DIMETHYLUREA; SCHEMBL15186954; Atglistatin, >=98% (HPLC); GTPL12995; EX-A293; AWOPBSAJHCUSAS-UHFFFAOYSA-N; HMS3653A18; HMS3744A05; BCP27988; BDBM50185419; s7364; AKOS026750242; CCG-267281; compound 4 [PMID: 24096302]; NCGC00371133-07; NCGC00371133-10; AC-35213; AS-16730; HY-15859; SY038696; FT-0700208; SW220102-1; EN300-172737; A884474; SR-03000003442; J-690187; SR-03000003442-1; 2-[(N-Benzyl-L-phenylalanyl)amino]-5-iodobenzoic acid; Z1785637773; Urea, N'-[4'-(dimethylamino)[1,1'-biphenyl]-3-yl]-N,N-dimethyl-; 3-[4 inverted exclamation mark -(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea. Grade: 0.98. CAS No. 1469924-27-3. Molecular formula: C17H21N3O. Mole weight: 283.37. | |
| ATH-18534 | ATH-18534 is an antibacterial agent. Uses: Bacterial infections. Synonyms: ATH-18534; ATH 18534; ATH18534; UNII-V78F7TLP21; SCHEMBL3236065; 6-methyl-3-(2-propen-1-ylthio)-1,2,4-Triazin-5(2H)-one. Grade: 98%. CAS No. 87450-64-4. Molecular formula: C7H9N3OS. Mole weight: 183.23. | |
| Athidathion | Athidathion(GS-13006) is an organophosphate insecticide. Synonyms: GS-13006; GS13006; GS 13006. Grade: >98%. CAS No. 19691-80-6. Molecular formula: C8H15N2O4PS3. Mole weight: 330.38. | |
| Atibuclimab | Atibuclimab is a monoclonal antibody directed against CD14. Atibuclimab has been used in the research of acute lung injury. CAS No. 2417175-94-9. | |
| Atigliflozin | Atigliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor. It has antihyperglycemic activity and is used as an antihyperglycaemic drug candidate. Uses: Atigliflozin has antihyperglycemic activity and is used as an antihyperglycaemic drug candidate. Synonyms: β-D-Glucopyranoside, 2-[(4-methoxyphenyl)methyl]-3-thienyl; 2-((4-Methoxyphenyl)methyl)thiophen-3-yl-beta-d-glucopyranoside; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-[(4-methoxyphenyl)methyl]thiophen-3-yl]oxyoxane-3,4,5-triol. Grade: 98%. CAS No. 647834-15-9. Molecular formula: C18H22O7S. Mole weight: 382.43. | |
| Atinumab | Atinumab is a monoclonal antibody directed against reticulon-4. Atinumab acts as an immunomodulator. Synonyms: Anti-RTN4. Grade: 95%. CAS No. 1226761-65-4. | |
| Atipamezole | Atipamezole, a 4-substituted imidazole derivative, is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering blood pressure and increasing heart rate and breathing rate. Uses: Atipamezole is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering blood pressure and increasing heart rate and breathing rate. Synonyms: atipamezole; 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; 4-(2-Ethyl-2-indanyl)imidazole; MPV-1248; MPV 1248; MPV1248. Grade: 98%. CAS No. 104054-27-5. Molecular formula: C14H16N2. Mole weight: 212.29. | |
| Atipamezole Hydrochloride | The hydrochloride salt form of atipamezole that is an alpha2-adrenoceptor blocker which could be used for animals to recover from the anesthesia by lowering blood pressure and increasing heart rate and breathing rate. Synonyms: 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride; Atipamezole HCl; 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride; 4-(2-Ethyl-2-indanyl)imidazole hydrochloride; Atipamezole hydrochloride. Grade: 98%. CAS No. 104075-48-1. Molecular formula: C14H16N2.HCl. Mole weight: 248.75. | |
| Atiprimod | atiprimod is orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Synonyms: azaspirane; SKF 106615; SKF106615; SKF-106615; SK&F 106615; SK&F-106615. CAS No. 123018-47-3. Molecular formula: C22H44N2. Mole weight: 336.60. | |
| Atiprimod dihydrochloride | Atiprimod dihydrochloride is the dihydrochloride salt form of atiprimod, which is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents. It is a JAK2 inhibitor with IC50 value of 397 nM. It has anti-inflammatory, antineoplastic, and anti-angiogenic activities. It inhibits the phosphorylation of signal transducer and activation of transcription 3 (STAT3) and STAT5. It downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1 and blocks the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF). It also inhibits cell growth, induction of cell cycle arrest, and apoptosis in cells expressing the JAK2V617F mutation. Synonyms: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine dihydrochloride. CAS No. 130065-61-1. Molecular formula: C22H46N2Cl2. Mole weight: 409.52. | |
| Atiratecan | Atiratecan is a topoisomerase inhibitor. It has potential anticancer activity. Uses: Anticancer. Synonyms: (S)-9-ethyl-10,13-dioxo-1-pentyl-9,10,13,15-tetrahydro-1H,12H-pyrano[3'',4'':6',7']indolizino[2',1':5,6]pyrido[4,3,2-de]quinazolin-9-yl N-glycyl-N-methylglycinate. Grade: 98%. CAS No. 867063-97-6. Molecular formula: C31H34N6O6. Mole weight: 586.65. | |
| ATL-313-d4 | Isotope labelled analogue of ATL-313, an adenosine A2A receptor agonist used as a potential treatment of spinal cord injury in preventing the apoptotic process that is an important step of secondary damage after spinal cord injury. Synonyms: 4-[3-[6-Amino-9-(N-cyclopropyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-1-piperidinecarboxylic Acid-d4 Methyl Ester; DE 112-d4; Evodenoson-d4. Molecular formula: C23H25D4N7O6. Mole weight: 503.54. | |
| ATM-3507 trihydrochloride | ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are 3.83-6.84 μM. Grade: 98%. Molecular formula: C37H49Cl3FN5O2. Mole weight: 721.17. | |
| ATM Inhibitor-1 | ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor (IC50 = 0.7 nM) with anti-tumor activity. It shows weak activity against mTOR (IC50 = 21 μM), DNAPK (IC50 = 2.8 μM), PI3K (IC50 = 3.8 μM), PI3K (IC50 = 10.3 μM), PI3K (IC50 = 3 μM) and PI3K (IC50 = 0.73 μM). Synonyms: ATM Inhibitor-1; 2135639-94-8; CHEMBL4218854; 6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide; SCHEMBL19384258; BDBM50459003; AKOS040732485; HY-112614; CS-0047699. CAS No. 2135639-94-8. Molecular formula: C27H36N6O3. Mole weight: 492.61. | |
| ATN-161 trifluoroacetate salt | ATN-161 trifluoroacetate salt is a beta integrin antagonist with antitumor activity. It is a five -amino-acid peptide derived from the synergy region of fibronectin. It inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation. Synonyms: ATN-161 TFA salt; ATN 161 TFA salt; ATN161 TFA salt. Grade: >98%. CAS No. 904763-27-5. Molecular formula: C25H36F3N9O10S. Mole weight: 711.67. | |
| ATN-163 | ATN-163 is a scramble peptide of ATN-161 which is a five-amino acid peptide with documented anti-angiogenic activity. Synonyms: ATN163; ATN 163; ATN-163; AcHSPNCNH2; LCysteinamide NacetylLhistidylLserylLprolylLasparaginyl. Grade: >98%. CAS No. 915398-40-2. Molecular formula: C23H35N9O8S. Mole weight: 597.64. | |
| ATN-224 | ATN-224 is an oral Cu2+/Zn2+ superoxide dismutase 1 (SOD1) inhibitor that inhibits SOD1 activity in endothelial cells in a dose-dependent manner with an IC50 of 17.5±3.7 nM. Synonyms: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1); 2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate (2:1); ALXN 1840; ATN 224; ATN224; Bis(choline)tetrathiomolybdate; Tiomolibdate Choline; WTX 101; 2-Hydroxy-N,N,N-trimethylethan-1-aminium tetrathiomolybdate; Choline tetrathiomolybdate. Grade: ≥95%. CAS No. 649749-10-0. Molecular formula: C5H14NO.1/2MoS4. Mole weight: 432.54. | |
| Atocalcitol | Atocalcitol, a vitamin D3 analogue, is used in the study for psoriasis. Synonyms: Atocalcitolum; 1,3-Cyclohexanediol,4-methylene-5-[(2E)-[(1R,3aS,7aR)-octahydro-1-[(1R)-2-[[3-(1-hydroxy-1-methylethyl)phenyl]methoxy]-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-. Grade: 95%. CAS No. 302904-82-1. Molecular formula: C32H46O4. Mole weight: 494.71. | |
| Atomoxetine | Atomoxetine is a selective inhibitor of noradrenaline reuptake. Atomoxetine was originally called tomoxetine but changed to avoid any potential confusion with tamoxifen that might lead to errors in dispensing the drug. It is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. Synonyms: N-methyl-γR-(2-methylphenoxy)-benzenepropanamine; Atomoxetine; HSDB 7352; HSDB-7352; HSDB7352. Grade: ≥98%. CAS No. 83015-26-3. Molecular formula: C17H21NO. Mole weight: 255.4. | |
| Atomoxetine EP Impurity A HCl | Atomoxetine EP Impurity A HCl is a hydrochloride circuit impurity of Atomoxetine manifesting as a selective norepinephrine reuptake inhibitor (NRI) prescribed predominantly for ADHD, albeit sporadically utilized for major depressive disorder. Synonyms: N-methyl-3-phenoxy-3-phenyl-propylamine hydrochloride. Grade: > 95%. CAS No. 873310-33-9. Molecular formula: C16H20NOCl. Mole weight: 277.79. | |
| Atomoxetine EP Impurity F | Atomoxetine EP Impurity F is a derivative of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Synonyms: 3-Fluoro (S)-Atomoxetine; (3S)-3-(3-Fluoro-2-methylphenoxy)-N-methyl-3-phenylpropan-1-amine; (3S)-N-Methyl-3-(3-fluoro-2-methylphenoxy)-3-phenylpropan-1-amine. Molecular formula: C17H20FNO. Mole weight: 273.34. | |
| Atomoxetine HCl | Atomoxetine is a norepinephrine reuptake inhibitor approved for the treatment of attention deficit hyperactivity disorder (ADHD). Synonyms: DL8280; DL 8280; DL-8280. Grade: >98%. CAS No. 82248-59-7. Molecular formula: C17H22ClNO. Mole weight: 291.82. | |
| Atomoxetine Impurity B | Atomoxetine Impurity B is an impurity of atomoxetine drug formulations. Atomoxetine is a medication primarily used to treat attention deficit hyperactivity disorder (ADHD) in both children and adults. Grade: > 95%. CAS No. 105314-53-2. Molecular formula: C17H21NO. Mole weight: 255.36. | |
| Atomoxetine Impurity D | Atomoxetine Impurity D is an impurity of atomoxetine which is specifically tailored to treat attention deficit hyperactivity disorder (ADHD). Synonyms: (3R)-N-methyl-3-(3-methylphenoxy)-3-phenylpropan-1- amine. Grade: > 95%. CAS No. 873310-29-3. Molecular formula: C17H21NO. Mole weight: 255.36. | |
| Atomoxetine-N-amide | Atomoxetine-N-amide is a derivative of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Synonyms: Atomoxetine-N-Amide Impurity; (R)-1-Methyl-1-(3-phenyl-3-(o-tolyloxy)propyl)urea; Atomoxetine Impurity 2. Molecular formula: C18H22N2O2. Mole weight: 298.38. | |
| Atopaxar | Atopaxar is a Protease-activated receptor-1 (PAR-1) inhibitor. It can inhibit the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 value of 0.019μM. Atopaxar exhibits potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 0.064 and 0.031μM. It may become a therapeutic option for atherothrombotic disease. In May 2012, Phase-II for Acute coronary syndromes in European Union was discontinued. Uses: Acute coronary syndromes. Synonyms: E5555; E-5555; E 5555; ER-172594-00; ER172594-00; ER 172594-00; Atopaxar; 1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethan-1-one; 474550-69-1(hydrobromide). Grade: 98%. CAS No. 751475-53-3. Molecular formula: C29H38FN3O5. Mole weight: 527.64. | |
| Atorvastatin | Atorvastatin, a HMG-CoA reductase inhibitor, could be used to reduce cholesterol and prevent cardiovascular related disease. Uses: Atorvastatin is a hmg-coa reductase inhibitor that could be used to reduce cholesterol and prevent cardiovascular related disease. Synonyms: Atorvastatin; (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(pheynylcarbamoyl)pyrrol-1-yl]-3,5-dihydro heptanoic acid. Grade: 95%. CAS No. 134523-00-5. Molecular formula: C33H35FN2O5. Mole weight: 558.64. | |
| Atorvastatin 2-Fluoro Analog | Atorvastatin 2-Fluoro Analog is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: (3R,5R)-7-(2-(2-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenyl carbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid calcium(II). CAS No. 2243639-98-5. Molecular formula: C66H68CaF2N4O10. Mole weight: 1155.36. | |
| Atorvastatin 3-Deoxyhept-2E-Enoic Acid | Atorvastatin 3-Deoxyhept-2E-Enoic Acid is an impurity of Atorvastatin, which is an HMG-CoA reductase inhibitor used to reduce cholesterol and prevent cardiovascular-related disease. Synonyms: (S,E)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-5-hydroxyhept-2-enoic acid; Atorvastatin 3-deoxyhept-2-enoic acid; (2E)-2,3-Dehydroxy Atorvastatin; 2-Heptenoic acid, 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-, (2E,5S)-; (2E,5S)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-2-heptenoic acid. Grade: ≥95%. CAS No. 1105067-93-3. Molecular formula: C33H33FN2O4. Mole weight: 540.64. | |
| Atorvastatin 3-Deoxyhept-2E-Enoic Acid (Calcium Salt) | An impurity of Atorvastatin, a statin medication used to treat cardiovascular disease. Synonyms: (2E)-2,3-Dehydroxy Atorvastatin calcium; (2E,5S)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-2-heptenoic Acid calcium salt. Grade: > 95%. Molecular formula: C66H64F2N4O8Ca. Mole weight: 1119.33. | |
| Atorvastatin 3-Deoxyhept-2Z-Enoic Acid Sodium Salt | Atorvastatin 3-Deoxyhept-2Z-Enoic Acid Sodium Salt is an exemplary pharmaceutical compound, used for hypercholesterolemia research. Its mechanism entails serving as a competitive inhibitor of HMG-CoA reductase, curtailing hepatic cholesterol synthesis. Grade: > 95%. CAS No. 1659317-56-2. Molecular formula: C33H32FN2O4Na. Mole weight: 562.62. | |
| Atorvastatin Acetonide | Atorvastatin Acetonide is the impurity of Atorvastatin, which is a selective, competitive HMG-CoA reductase inhibitor. Synonyms: [(4R,6R)-6-[2-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic Acid; Atorvastatin Impurity 2. Grade: > 95%. CAS No. 581772-29-4. Molecular formula: C36H39FN2O5. Mole weight: 598.72. | |
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