BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AVE-0118 | AVE 0118 is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to the anti-AF property of AVE0118. Synonyms: [1,1'-Biphenyl]-2-carboxamide, 2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide; AVE 0118; AVE0118. Grade: ≥95%. CAS No. 498577-53-0. Molecular formula: C30H29N3O3. Mole weight: 479.57. |  |
| AVE 0118 hydrochloride | AVE 0118 hydrochloride is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to anti-AF property of AVE0118. Synonyms: Benzeneacetamide, 4-methoxy-N-[[2'-[[[2-(3-pyridinyl)ethyl]amino]carbonyl][1,1'-biphenyl]-2-yl]methyl]-, hydrochloride (1:1); 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide hydrochloride; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-, hydrochloride; 2'-[[2-(4-Methoxyphenyl)acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide hydrochloride; AVE 0118 hydrochloride; AVE0118 hydrochloride. Grade: 99%. CAS No. 2108821-80-1. Molecular formula: C30H29N3O3.HCl. Mole weight: 516.03. | |
| AVE 0991 | AVE 0991 is an agonist of nonpeptide Ang-(1-7) receptor Mas that has potential as a cardiovascular drug. Synonyms: 1-ethyl-3-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylurea5-formyl-4-methoxy-2-phenyl-1-((4-(2-ethyl-aminocarbonylsulfonamido-5-isobutyl-3-thienyl)phenyl)methyl)imidiazoleAVE 0991; AVE-0991; AVE0991. CAS No. 304462-19-9. Molecular formula: C29H32N4O5S2. Mole weight: 580.72. | |
| AVE 0991 sodium salt | AVE 0991 sodium salt, is an agonist of nonpeptide Ang-(1-7) receptor Mas that has potential as a cardiovascular drug. Synonyms: AVE-0991 sodium salt; AVE 0991 sodium salt; AVE0991 sodium salt; sodium; ethylcarbamoyl-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylazanideAVE 0991 (sodium salt)306288-04-0C29H31N4NaO5S23195AH. CAS No. 306288-04-0. Molecular formula: C29H31N4NaO5S2. Mole weight: 602.70. | |
| AVE-8063 | AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity. Synonyms: AVE8063; AVE 8063; (Z)-1-(3-Amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene; (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl) aniline. Grade: >98%. CAS No. 162705-07-9. Molecular formula: C18H21NO4. Mole weight: 315.37. | |
| AVE-8134 | AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively. Synonyms: AVE8134; 2-Methyl-6-((3-((2-phenyloxazol-4-yl)methoxy)propoxy)methyl)benzoic acid. CAS No. 304025-09-0. Molecular formula: C22H23NO5. Mole weight: 381.42. | |
| Avenanthramide-C methyl ester | Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 = 40 μM). Synonyms: Avenanthramide-C methyl ester; 955382-52-2; methyl 2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-5-hydroxybenzoate; SCHEMBL20963041; IUZHCICFVDHVMC-XVNBXDOJSA-N; AKOS040755114; Methyl (E)-2-(3-(3,4-dihydroxyphenyl)acrylamido)-5-hydroxybenzoate; 2-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxy-benzoic acid, methyl ester; 2-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxybenzoic acid, methyl ester. Grade: ≥90%. CAS No. 955382-52-2. Molecular formula: C17H15NO6. Mole weight: 329.3. | |
| Avenanthramide D | Avenanthramide D is a multifaceted bioactive compound with antioxidant, anti-inflammatory and cardiovascular protective effects used in studying diabetes, cancer and cardiovascular disorders. Synonyms: Avenanthramide 1p; Dianthramide P; N-p-Coumarylanthranilic acid; N-(E)-p-Coumaroylanthranilic acid. CAS No. 115610-36-1. Molecular formula: C16H13NO4. Mole weight: 283.28. | |
| Avibactam | Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed for possible use in combination with ceftaroline in the U.S. Avibactam does not have any intrinsic antibacterial activity in its own right, but appears to be capable of inhibiting beta-lactamase enzymes that belong to molecular classes A and C.Avibactam is useful for Antibiotics. Uses: Beta-lactamase inhibitors. Synonyms: Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester; Avibactam free acid; [(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate. Grade: >98%. CAS No. 1192500-31-4. Molecular formula: C7H11N3O6S. Mole weight: 265.24. | |
| Avibactam Impurity 11 | Avibactam Impurity 11 is an impurity of Avibactam. Synonyms: Avibactam Impurity 11; 1416134-60-5; Ethyl 5-phenylmethoxyiminopiperidine-2-carboxylate; Avibactam Impurity 15; (S,E)-ethyl 5-((benzyloxy)imino)piperidine-2-carboxylate. Grade: > 95%. CAS No. 1416134-60-5. Molecular formula: C14H18N2O3. Mole weight: 262.31. | |
| Avibactam Impurity 3 | Avibactam Impurity 3 is an impurity of Avibactam. Synonyms: (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide; 2-Piperidinecarboxamide, 5-[(phenylmethoxy)amino]-, (2S,5R)-; (2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide; 5R-(5-Benzyloxyamino) L-Pipecolic Amide. Grade: > 95%. CAS No. 1416134-49-0. Molecular formula: C13H19N3O2. Mole weight: 249.32. | |
| Avibactam Impurity 6 | An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; (1R,2S,5R)-7-Oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. Grade: >95%. CAS No. 1192651-49-2. Molecular formula: C14H17N3O3. Mole weight: 275.31. | |
| Avibactam Impurity 9 | Avibactam Impurity 9 is an impurity of Avibactam. Synonyms: Avibactam Intermediate; (2S,5R)-5-[(Phenylmethoxy)amino]-2-piperidinecarboxylic Acid Ethyl Ester Ethanedioate; (2S,5R)-Ethyl 5-((benzyloxy)amino)piperidine-2-carboxylate Oxalate. Grade: > 95%. CAS No. 1416134-48-9. Molecular formula: C17H24N2O7. Mole weight: 377.39. | |
| Avibactam Sodium, (+)- | An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (2R,5S)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo(3.2.1)octane-2-carboxamide monosodium salt. Grade: ≥95%. CAS No. 1383814-68-3. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23. | |
| Avibactam sodium hydrate | Avibactam is a reversible β-lactamase inhibitor (IC50 = 8/80/38 nM for TEM-1/P99/KPC-2 β-lactamases). Synonyms: NXL-104 hydrate. Molecular formula: C7H12N3NaO7S. Mole weight: 305.24. | |
| Avibactam Sodium Salt | Avibactam Sodium Salt, a novel non-?-lactam ?-lactamase inhibitor, binds covalently to Ambler class A ?-lactamases, including KPCs, Ambler class C and some class D b-lactamases. In combination with ceftazidime, Avibactam is a new drug application for avibactam , and was approved by the FDA on February 25, 2015, to treat complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens. Avibactam has limited intrinsic antimicrobial activity but restores the in vitro activity of b-lactams including ceftazidime, ceftaroline, the active metabolite of ceftaroline fosamil, and aztreonam against ESBL-producing pathogens. Synonyms: sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[321]octan-6-yl sulfate; NXL104; NXL-104; NXL 104; Avibactam; Avibactam sodium. CAS No. 1192491-61-4. Molecular formula: C7H10N3NaO6S. Mole weight: 287.23. | |
| Avitinib | Avitinib (AC0010) is a third generation inhibitor of the EGFR (epidermal growth factor receptor) that was permitted parallel phase I clinical trials in the US. It is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR. Uses: Tyrosine kinase inhibitors. Synonyms: AC0010. Grade: ≥98%. CAS No. 1557267-42-1. Molecular formula: C26H26FN7O2. Mole weight: 487.5. | |
| Avitinib maleate | Avitinib maleate, the maleate salt form of avitinib, is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) mutant-selective inhibitor (IC50 = 7.68 nM), with potential antineoplastic activity. Uses: Tyrosine kinase inhibitors. Synonyms: Avitinib maleate; AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010. CAS No. 1557268-88-8. Molecular formula: C30H30FN7O6. Mole weight: 603.6. | |
| Avitriptan | Avitriptan is an antimigraine drug of the triptan family which was never marketed. It acts as a 5-HT1B and 5-HT1D receptor agonist. Synonyms: 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide. Grade: > 95%. CAS No. 151140-96-4. Molecular formula: C22H30N6O3S. Mole weight: 458.59. | |
| AVL-292 | AVL-292, also known as CC-292, is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, AVL-292 targets and covalently binds to BTK, thereby preventing its activity. Uses: Protein kinase inhibitors. Synonyms: CC-292; CC292; CC 292; AVL292; AVL 292; spebrutinib. Grade: 98%. CAS No. 1202757-89-8. Molecular formula: C22H22FN5O3. Mole weight: 423.44. | |
| AVL-292 benzenesulfonate | AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed. Synonyms: Spebrutinib besylate; CC-292 besylate; AVL-292 benzenesulfonate; CC 292 besylate; AVL 292 benzenesulfonate; CC292 besylate; AVL292 benzenesulfonate. Grade: >98%. CAS No. 1360053-81-1. Molecular formula: C28H28FN5O6S. Mole weight: 581.62. | |
| AVN-101 hydrochloride | AVN-101 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT7, 5-HT2C, 5-HT2A, and 5-HT6 (Kis = 0.153, 1.17, 1.56, and 2.04 nM, respectively). It is also an antagonist of α2A-, α2B-, α2C-, α1B-, α1A-, and α1D-adrenergic receptors (Kis = 0.41, 1.77, 3.55, 9.4, 18.9, and 30.2 nM, respectively), as well as histamine H1 and H2 (Kis = 0.58 and 89 nM, respectively), but not H3, receptors. It is a multi-target drug candidate for the treatment of CNS disorders. Synonyms: 2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride; AVN-101 HCl; 1H-Pyrido(4,3-b)indole, 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-, hydrochloride (1:1); 2,8-dimethyl-5-(2-phenylethyl)-1H,2H,3H,4H,5H-pyrido[4,3-b]indole hydrochloride; 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-1H-pyrido[4,3-b]indole, monohydrochloride. Grade: ≥95%. CAS No. 1061354-48-0. Molecular formula: C21H25ClN2. Mole weight: 340.90. | |
| AVN-211 | This active molecular is a Selective 5-HT6 Receptor antagonist, for the treatment of Alzheimer's Disease under development by by Avineuro Pharmaceuticals. AVN-211 shows good anxiolytic efficacy, low toxicity ,no side effects in vivo, an appropriate pharmacokinetic profile and good stability. AVN-211 significantly delayed or partially halted the progressive decline in memory function associated with AD and this efficacy makes it an interesting drug candidate for the treatment of neurodegenerative and psychiatric disorders. In Jul 2015, Avineuro Pharmaceuticals completed a phase II trial in Schizophrenia in USA and planed a trial for Alzheimer's disease in USA. In Aug 2015, Phase-II development was ongoing for Schizophrenia in USA. Uses: Alzheimer's disease;schizophrenia. Synonyms: AVN-211; AVN 211; AVN211; CD-008-0173. 5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine,CD-008-0173. Grade: 98%. CAS No. 1173103-84-8. Molecular formula: C15H15N3O2S2. Mole weight: 333.42. | |
| AVN-492 | AVN-492 is a novel potent and selective 5-HT6 receptor antagonist with Ki values of 91 pM and 170 nM for 5-HT6R and 5-HT2BR, respectively. Uses: Serotonin antagonists. Synonyms: AVN-492; AVN 492; AVN492. 3-(benzenesulfonyl)-2-N,6-N,6-N,5,7-pentamethylpyrazolo[1,5-a]pyrimidine-2,6-diamine. CAS No. 1220646-23-0. Molecular formula: C17H21N5O2S. Mole weight: 359.45. | |
| AVN-944 | AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. Synonyms: code name: AVN 944; AVN944; VX-944; VX 944; VX944. Grade: 0.98. CAS No. 297730-17-7. Molecular formula: C25H27N5O5. Mole weight: 477.51. | |
| Avoralstat | Avoralstat, also known as BCX-4161, is an oral plasma kallikrein (PKK) inhibitor and Bradykinin inhibitor, used to treat hereditary angioedema. Synonyms: BCX-4161; BCX 4161; BCX4161. CAS No. 918407-35-9. Molecular formula: C28H27N5O5. Mole weight: 513.54. | |
| Avosentan | Avosentan, also known as SPP301, R-639, and RO 67-0565, is a potent and selective endothelin receptor(ETA receptor) antagonist. Synonyms: N-[6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-ylpyrimidin-4-yl]-5-methylpyridine-2-sulfonamide; Avosentan; 290815-26-8; UNII-L94KSX715K; SPP301; SPP301; SPP301; RO 67-0565; RO-67-0565; RO67-0565; R-639; Avosentan. Grade: 95%. CAS No. 290815-26-8. Molecular formula: C23H21N5O5S. Mole weight: 479.51. | |
| Avotaciclib | Avotaciclib is a potent and orally active CDK1 inhibitor that can be studied in locally advanced or metastatic pancreatic cancer. Synonyms: BEY1107; 3-Pyridinol, 2,6-bis(2-amino-4-pyrimidinyl)-. CAS No. 1983983-41-0. Molecular formula: C13H11N7O. Mole weight: 281.27. | |
| Avotaciclib trihydrochloride | Avotaciclib trihydrochloride is a potent and orally active CDK1 inhibitor that can be studied in locally advanced or metastatic pancreatic cancer. Synonyms: BEY1107 trihydrochloride; 3-Pyridinol, 2,6-bis(2-amino-4-pyrimidinyl)-, hydrochloride (1:3). CAS No. 1983984-01-5. Molecular formula: C13H11N7O.3HCl. Mole weight: 390.66. | |
| Avridine | Avridine is a potent synthetic non-immunogenic adjuvant that used to induce arthritis in Lewis (LEW) and DA rats. Uses: A potent synthetic non-immunogenic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing. Synonyms: CP 20961; CP20961; CP-20961; N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane. Grade: ≥98%. CAS No. 35607-20-6. Molecular formula: C43H90N2O2. Mole weight: 667.19. | |
| AVX 13616 | AVX 13616 shows the potent in vivo antibacterial activity of Avexa's lead antibacterial candidate, particularly against drug-resistant Staphylococcus pathogens. It was as active as mupirocin in a nasal decolonization model but required only a single application. It showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. Synonyms: AVX-13616; AVX 13616; AVX13616. Grade: >98%. CAS No. 900814-48-4. Molecular formula: C50H73Cl2N7O7. Mole weight: 955.06. | |
| Avycaz | Avycaz is a fixed-dose combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. Synonyms: ceftazidime & avibactam; ceftazidime + avibactam; Avibactam / Ceftazidime. CAS No. 1393723-27-7. Molecular formula: C29H33N9O13S3. Mole weight: 811.8. | |
| AWD 12-281 | AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration. Synonyms: N-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide; AWD 12-281; AWD12-281; AWD-12-281; UNII-550671J24D; GSK 842470; GSK 842470; GSK-842470. Grade: >98%. CAS No. 257892-33-4. Molecular formula: C22H14Cl2FN3O3. Mole weight: 458.27. | |
| AWD 131-138 | AWD 131-138 is a partial agonist of GABAA receptor with low affinity for the benzodiazepine binding site. AWD 131-138 exhibits potent anticonvulsant and anxiolytic properties in rodent models. It is used as an antiepileptic drug for the treatment of canine idiopathic epilepsy. Synonyms: AWD 131-138; AWD-131-138; AWD131-138; AWD 131138; Imepitoin; 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one. CAS No. 188116-07-6. Molecular formula: C13H14ClN3O2. Mole weight: 279.724. | |
| AX-024 | AX-024 is a first-in-class and orally available TCR-Nck interaction inhibitor that selectively inhibits TCR-triggered T cell activation with an IC50 of ~1 nM. It regulates cell signaling by targeting SH3 domains. It strongly inhibits the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A. Synonyms: 1-[[4-(4-Fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]pyrrolidine; Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-. Grade: ≥98%. CAS No. 1370544-73-2. Molecular formula: C21H22FNO2. Mole weight: 339.40. | |
| AX-024 hydrochloride | AX-024 hydrochloride is an inhibitor of T cell receptor (TCR) that selectively inhibits the TCR-Nck interaction. By modulating TCR signaling, AX-024 prevents the development of psoriasis and asthma and, furthermore, exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. Synonyms: 1-[[4-(4-Fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]pyrrolidine hydrochloride; Pyrrolidine, 1-[[4-(4-fluorophenyl)-6-methoxy-2H-1-benzopyran-3-yl]methyl]-, hydrochloride (1:1). Grade: 99%. CAS No. 1704801-24-0. Molecular formula: C21H22FNO2.HCl. Mole weight: 375.86. | |
| AX 048 | Ethyl 4-[(2-oxohexadecanoyl)amino]butanoate (AX 048) is a PLA2 (Phospholipase A2) and PGE2 (Prostaglandin E2) inhibitor. PLA2 is known as calcium-dependent cytosolic PLA2 (cPLA2), which selectively releases arachidonic acid from membrane phospholipids. It plays a central role in initiating the synthesis of prostaglandins and leukotrienes. This compound also contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. Synonyms: AX-048; AX 048; Butanoic acid, 4-((1,2-dioxohexadecyl)amino)-, ethyl ester; UNII-8782Z45DLV; 8782Z45DLV; Butanoic acid, 4-[(1,2-dioxohexadecyl)amino]-, ethyl ester; ethyl 4-(2-oxohexadecanoylamino)butanoate; ethyl 4-(2-oxohexadecanamido)butanoate; CHEMBL574723; SCHEMBL4781039; DTXSID60236282; AKOS040755666; ethyl 4-[(2-oxohexadecanoyl)amino] butanoate; Q27269809; 4- [(1, 2- dioxohexadecyl)amino]- butanoic acid, ethyl ester. Grade: ≥98%. CAS No. 873079-69-7. Molecular formula: C22H41NO4. Mole weight: 383.6. | |
| AX-15836 | AX-15836 is a highly potent and selective ERK5 inhibitor (IC50 = 8 nM) with >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Synonyms: 2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methyl-11-methylsulfonylpyrimido[4,5-b][1,4]benzodiazepin-6-one; AKOS030210962; ZINC669678933; AX15836; AX 15836; AX-15836. CAS No. 2035509-96-5. Molecular formula: C32H40N8O5S. Mole weight: 648.78. | |
| AX20017 | AX20017 is a highly selective PknG inhibitor. It acts by blocking the proliferation of M. tuberculosis. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10μM or higher) that does not otherwise affect the growth of BCG outside its infected host. Synonyms: AX 20017; AX-20017; PknG Inhibitor; 2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide. Grade: ≥98% (HPLC). CAS No. 329221-38-7. Molecular formula: C13H16N2O2S. Mole weight: 264.35. | |
| AXC-715 | AXC-715 is a dual agonist of TLR7/TLR8. Synonyms: 1H-Imidazo[4,5-c]quinoline-1-butanamine, 4-amino-2-butyl-; 4-Amino-2-butyl-1H-imidazo[4,5-c]quinoline-1-butanamine; 1-(4-Aminobutyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine; AXC 715; AXC715. Grade: ≥95%. CAS No. 313350-31-1. Molecular formula: C18H25N5. Mole weight: 311.43. | |
| AXC-715 hydrochloride | AXC-715 hydrochloride is a dual agonist of TLR7/TLR8. (Extracted from patent WO2020168017 A1). Synonyms: 1-(4-Aminobutyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride; 1H-Imidazo[4,5-c]quinoline-1-butanamine, 4-amino-2-butyl-, hydrochloride (1:1). Grade: ≥90%. CAS No. 2490497-93-1. Molecular formula: C18H26ClN5. Mole weight: 347.89. | |
| AXC-715 trihydrochloride | AXC-715 trihydrochloride is a dual agonist of TLR7/TLR8. (Extracted from patent WO2020168017 A1). Synonyms: 1-(4-Aminobutyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine Trihydrochloride; 1H-Imidazo[4,5-c]quinoline-1-butanamine, 4-amino-2-butyl-, hydrochloride (1:3). Grade: 95%. CAS No. 2479276-17-8. Molecular formula: C18H28Cl3N5. Mole weight: 420.81. | |
| Axitinib Impurity 1 | Axitinib Impurity 1 is an impurity of Axitinib, a drug primarily used in the treatment of advanced renal cell carcinoma and metastatic thyroid cancer. Synonyms: Axitinib Impurity c. Grade: > 95%. CAS No. 885126-40-9. Molecular formula: C22H18N4OS. Mole weight: 386.48. | |
| Axitinib Impurity 2 | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide). Grade: > 95%. CAS No. 1428728-83-9. Molecular formula: C44H36N8O2S2. Mole weight: 772.96. | |
| Axitinib Impurity 6 | Axitinib Impurity 6 is an impurity arising from the depths of Axitinib - an oral tyrosine kinase inhibitor profoundly employed in the therapy against advanced renal carcinoma. Synonyms: Axitinib Impurity d. Grade: > 95%. CAS No. 1443118-72-6. Molecular formula: C29H25N5OS. Mole weight: 491.62. | |
| Axitinib Impurity 8 | Axitinib Impurity 8 is an impurity of axitinib fortifying the therapy against the perilous adversity known as advanced renal carcinoma. Synonyms: 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide; BenzaMide, 2-(1H-indazol-6-ylthio)-N-Methyl-; Axitinib Impurity e. Grade: > 95%. CAS No. 944835-85-2. Molecular formula: C15H13N3OS. Mole weight: 283.35. | |
| Axitinib Impurity C | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide; Axitinib EP Impurity C; Axitinib Impurity 56. Grade: ≥95%. CAS No. 1959572-97-4. Molecular formula: C15H13N3O2S. Mole weight: 299.35. | |
| Axitinib Impurity D | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: 2-[(1-Acetyl-1H-indazol-6-yl)sulfinyl]-N-methylbenzamide; Axitinib EP Impurity D. Grade: ≥95%. CAS No. 1959572-98-5. Molecular formula: C17H15N3O3S. Mole weight: 341.38. | |
| Axitinib N-oxide | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: (E)-N-Methyl-2-[[3-[2-(1-oxido-2-pyridinyl)ethenyl]-2H-indazol-6-yl]thio]benzamide. Grade: ≥95%. Molecular formula: C22H18N4O2S. Mole weight: 402.47. | |
| Axitinib sulfone | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Sulfonyl axitinib; (E)-N-methyl-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylsulfonyl)benzamide; N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfonyl]benzamide. Grade: ≥95%. CAS No. 1348536-59-3. Molecular formula: C22H18N4O3S. Mole weight: 418.47. | |
| Axitinib sulfoxide | A major metabolite of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide; Axitinib Impurity A. Grade: > 95%. CAS No. 1347304-18-0. Molecular formula: C22H18N4O2S. Mole weight: 402.48. | |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. | |
| AZ0108 | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one; AZ0108; AZ-0108; AZ 0108. Grade: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
| AZ084 | AZ084 is a potent, selective, allosteric and orally active CCR8 antagonist with a Ki of 0.9 nM. It has the potential to treat asthma. Synonyms: Methanone, (5-amino-2-pyridinyl)[9-[(2,3-dihydro-2,2-dimethyl-4-benzofuranyl)methyl]-3,9-diazaspiro[5.5]undec-3-yl]-; (5-Amino-2-pyridinyl){9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}methanone. Grade: ≥97%. CAS No. 929300-19-6. Molecular formula: C26H34N4O2. Mole weight: 434.57. | |
| AZ 10397767 | AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grade: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88. | |
| AZ 10417808 | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grade: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
| AZ 10606120 dihydrochloride | AZ 10606120 dihydrochloride is the dihydrochloride salt of AZ 10606120, which is a potent and negative allosteric modulator of the human P2X7 receptor. Its KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively. It binds in a positive cooperative manner to sites and acts as a negative allosteric modulator. It is a key modulator of the PI3K/GSK3β/VEGF signaling network. It inhibits tumor growth and shows antiangiogenic effects in mice. Synonyms: AZ10606120; AZ 10606120; AZ-10606120; N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide Dihydrochloride; 2-(1-Adamantyl)-N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]quinolin-5-yl]acetamide Dihydrochloride. Grade: ≥98% by HPLC. CAS No. 607378-18-7. Molecular formula: C25H36N4O2Cl2. Mole weight: 495.48. | |
| AZ11645373 | AZ11645373 is a potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Uses: Purinergic p2x receptor antagonists. Synonyms: 2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-; 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione; AZ 11645373; AZ-11645373; 3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione. Grade: >98%. CAS No. 227088-94-0. Molecular formula: C24H21N3O5S. Mole weight: 463.51. | |
| AZ11665362 | AZ11665362 is a potent CRTH2 antagonist. It blocks the migration of eosinophils and basophils, and the rapid mobilization of eosinophils from bone marrow. It might be useful for the treatment of allergic diseases. Uses: Az11665362 might be useful for the treatment of allergic diseases. Synonyms: AZ-11665362; AZ 11665362; AZ11665362; (2,5-Dimethyl-3-(8-methyl-4-quinolinyl)-1H-indol-1-yl)acetic acid. Grade: 98%. CAS No. 629645-40-5. Molecular formula: C22H20N2O2. Mole weight: 344.41. | |
| AZ 12080282 dihydrochloride | AZ 12080282 dihydrochloride is a potent Hh inhibitor with IC50 value <0.012 μM. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency. Synonyms: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride. Grade: ≥98%. Molecular formula: C23H20N4O2ยท2HCl. Mole weight: 457.35. | |
| AZ 12216052 | AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grade: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. | |
| AZ12601011 | AZ12601011 is one of inhibitors of Transforming Growth Factor β Superfamily Type 1 receptors. Synonyms: AZ12601011; AKOS040732507; MS-24586; HY-122856; CS-0090034. Grade: 98%. Molecular formula: C19H15N5. Mole weight: 313.36. | |
| AZ12672857 | AZ12672857 is an orally active inhibitor of EphB4 and Src kinases. It shows potent inhibition of proliferation of c-Src transfected 3T3 cells (IC50 = 2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50 = 9 nM). Grade: 98%. CAS No. 945396-55-4. Molecular formula: C26H38N8O2. Mole weight: 486.57. | |
| AZ-1355 | AZ-1355 is an effective lipid-lowering agent. It inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro. Synonyms: 11,12-Dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate; AZ 1355; NSC 364889. CAS No. 75451-07-9. Molecular formula: C17H17NO4. Mole weight: 299.32. | |
| AZ13705339 | AZ13705339 is a potent and selective PAK1 inhibitor (IC50 = 0.33 nM). PAK1 is commonly overexpressed in breast tumors. Synonyms: AZ13705339; AZ 13705339; AZ-13705339; 2-[[N-[2-[3-ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrile. Grade: 99%. CAS No. 2016806-57-6. Molecular formula: C33H36FN7O3S. Mole weight: 629.75. | |
| AZ191 | AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grade: >98%. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| AZ2 | AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). Grade: 99%. CAS No. 2231760-33-9. Molecular formula: C20H23N3O2S. Mole weight: 369.48. | |
| AZ20 | In vitro, AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Synonyms: AZ20; AZ-20; AZ 20. Grade: >98%. CAS No. 1233339-22-4. Molecular formula: C21H24N4O3S. Mole weight: 412.51. | |
| AZ-2088 | AZ-2088 is a powerful and discriminating inhibitor exhibiting its prowess by selectively antagonizing the Akt pathway. Synonyms: AZ 2088; AZ2088; Dimethylheptyl(1-hydroxy-p-menth-2-yl)ammonium bromide; N-Heptyl-2-hydroxy-N,N,2-trimethyl-5-(propan-2-yl)cyclohexan-1-aminium bromide. Grade: >98%. CAS No. 20091-61-6. Molecular formula: C19H40BrNO. Mole weight: 378.44. | |
| AZ 23 | AZ 23 is a potent and selective tyrosine kinase (Trk) inhibitor with the potential for therapeutic utility in neuroblastoma and multiple other cancer indications. Uses: Multiple cancer therapy. Synonyms: AZ-23; AZ 23; AZ23; UNII-009OMI967N; 5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine. Grade: 99%. CAS No. 915720-21-7. Molecular formula: C17H19ClFN7O. Mole weight: 391.83. | |
Our database is helping our users find suppliers everyday.
