BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Bethanechol | Bethanechol, a synthetic ester structurally and pharmacologically related to acetylcholine, is a selective muscarinic receptor stimulant used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the abs. Uses: A selective muscarinic receptor stimulant, used to treat cerebral palsy. Synonyms: 1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-; Carbamyl-β-methylcholine; 2-carbamoyloxypropyl(trimethyl)azanium. Grade: 95%. CAS No. 674-38-4. Molecular formula: C7H17N2O2. Mole weight: 161.22. |  |
| Bethanechol Chloride | A selective muscarinic receptor stimulant, used to treat cerebral palsy. Uses: Parasympathomimetics. Synonyms: Bethanechol chloride; 590-63-6; Urecholine Myocholine Duvoid. Grade: 98%. CAS No. 590-63-6. Molecular formula: C7H17ClN2O2. Mole weight: 196.67. | |
| Bethanechol-d6 | Isotope labelled Bethanechol. Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Synonyms: 2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium-d6. Grade: > 95%. Molecular formula: C6H8N2O2D6. Mole weight: 152.23. | |
| Bethanechol-d6 Chloride | Isotope labelled Bethanechol Chloride. Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Synonyms: 2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium-d6 Chloride. Grade: > 95%. Molecular formula: C7H11N2O2D6·Cl. Mole weight: 202.66. | |
| Bethanidine Sulfate | This active molecular is a guanidinium antihypertensive agent through adrenergic neuron-blocking. Uses: Betanidine is an adrenergic neuron-blocking drug. Synonyms: N,N'-Dimethyl-N''-(phenylmethyl)-guanidine Sulfate; 1-Benzyl-2,3-dimethyl-guanidine sulfate; 1-Benzyl-2,3-dimethylguanidine Sulfate; 1-Benzyl-2,3-dimethylguanidinium Sulfate; BW 467C60; Batel; Bendogen; Benzaidin; Benzanidin; Benzanidine; Betanidol; Betanidole; Bethanid; Bethanidine hemisulfate; Esbatal; Eusmanid; Hypersin; NSC 106563; Regulin; Tenathan, 55-73-2 free amine. Grade: 98%. CAS No. 114-85-2. Molecular formula: C20H32N6O4S. Mole weight: 452.57. | |
| Bethoxazin | Bethoxazin(Bethoguard) is a new broad spectrum industrial microbicide with applications in material and coating preservation. Synonyms: Bethogard; Bethoguard. Grade: >98%. CAS No. 163269-30-5. Molecular formula: C11H9NO2S2. Mole weight: 251.32. | |
| BET-IN-1 | BET-IN-1, an oxazole derivative, can be used as a bromodomain inhibitor. Synonyms: 4-[8-methoxy-1-[(2R)-1-methoxypropan-2-yl]-2-(oxan-4-yl)imidazo[4,5-c]quinolin-7-yl]-3,5-dimethyl-1,2-oxazoleBET-IN-1; BET IN 1SCHEMBL14698278CS-5464; HY-19760; CS 5464; HY 19760; CS5464; HY19760. CAS No. 1422554-34-4. Molecular formula: C25H30N4O4. Mole weight: 450.53. | |
| BET-IN-2 | BET-IN-2 is an inhibitor of BET with an IC50 of 52 nM for BRD4-BD1. Synonyms: 2(1H)-Quinoxalinone, 4-cyclopropyl-6-[[(1S)-1-(2,4-dimethylphenyl)ethyl]amino]-3,4-dihydro-1,3-dimethyl-, (3R)-; (3R)-4-Cyclopropyl-6-{[(1S)-1-(2,4-dimethylphenyl)ethyl]amino}-1,3-dimethyl-3,4-dihydro-2(1H)-quinoxalinone. Grade: ≥95%. CAS No. 2104688-91-5. Molecular formula: C23H29N3O. Mole weight: 363.50. | |
| BET-IN-6 | BET-IN-6, a potent and high-affinity inhibitor of BRD2/BRD4, is a ligand of the target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 degradator-1. Synonyms: 3-(6-{[(2-Methoxyphenyl)sulfonyl]amino}-1-methyl-2-oxo-1,2-dihydrobenzo[cd]indol-4-yl)propanoic acid; Benz[cd]indole-4-propanoic acid, 1,2-dihydro-6-[[(2-methoxyphenyl)sulfonyl]amino]-1-methyl-2-oxo-. Molecular formula: C22H20N2O6S. Mole weight: 440.47. | |
| BETP | BETP is a positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor, displaying no effect on GLP-2, GIP, PTH or glucagon receptors. BETP promotes oxyntomodulin binding to GLP-1 receptor. It potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Synonyms: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine. Grade: ≥98% by HPLC. CAS No. 1371569-69-5. Molecular formula: C20H17F3N2O2S. Mole weight: 406.42. | |
| Betrixaban | A direct factor Xa inhibitor used as an oral anticoagulant drug. It has been prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE. Uses: Factor xa inhibitors. Synonyms: PRT054021; PRT 054021; PRT-054021; MK-4448; MK 4448; MK4448; PRT-021; PRT 021; PRT021; MLN-1021; MLN 1021; MLN1021; Bevyxxa; N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide. CAS No. 330942-05-7. Molecular formula: C23H22ClN5O3. Mole weight: 451.91. | |
| Betrixaban hydrochloride | Betrixaban is a potent, selective, and orally effective Factor Xa (fXa) inhibitor (IC50 = 1.5 nM) used as an oral anticoagulant. It has been prescribed for the prevention of venous thromboembolism (VTE) in adult patients with moderate to severe restricted motility or other risks of VTE. Synonyms: Benzamide, N-(5-chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxy-, hydrochloride (1:1); Betrixaban monohydrochloride; PRT 054021 hydrochloride; N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide hydrochloride. Grade: ≥95%. CAS No. 2099719-47-6. Molecular formula: C23H23Cl2N5O3. Mole weight: 488.37. | |
| Betrixaban maleate | Betrixaban maleate is the maleate salt form of Betrixaban, a direct factor Xa inhibitor used as an oral anticoagulant drug. CAS No. 936539-80-9. Molecular formula: C23H22ClN5O3.C4H4O4. Mole weight: 567.98. | |
| bevacizumab-awwb | Bevacizumab-awwb is the first anti-cancer biosimilar and the first bevacizumab biosimilar approved for the treatment of five types of cancer, including in combination with chemotherapy for non-squamous non-small cell lung cancer (NSCLC), in combination with chemotherapy for metastatic colorectal cancer (mCRC), in combination with interferon alfa for glioblastoma, metastatic renal cell carcinoma and in combination with chemotherapy for persistent, recurrent, or metastatic carcinoma of the cervix. Uses: The traetment of nsclc, etc. Synonyms: Mvasi. | |
| Bevantolol Hydrochloride | Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Synonyms: 2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride; 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride. Grade: ≥95%. CAS No. 42864-78-8. Molecular formula: C20H28ClNO4. Mole weight: 381.89. | |
| Bevasiranib | Bevasiranib is an anti-VEGF small interfering RNA (siRNA). VEGF is a key component in the pathogenesis of choroidal neo-vascularization (CNV), which is a precursor to wet AMD. Bevasiranib has been used in wet AMD research. Synonyms: RNA, (A-C-C-U-C-A-C-C-A-A-G-G-C-C-A-G-C-A-C-dT-dT), complex with RNA (G-U-G-C-U-G-G-C-C-U-U-G-G-U-G-A-G-G-U-dT-dT) (1:1). Grade: 95%. CAS No. 959961-96-7. | |
| Bevenopran | Bevenopran is a peripherally selective μ- and δ-opioid receptor antagonist. It is used for the treatment of chronic opioid-induced constipation. It was developed by Cubist Pharmaceuticals and was in clinical phase 3 trial, but now it is terminated. Uses: Bevenopran is used for the treatment of chronic opioid-induced constipation. Synonyms: 5-(2-Methoxy-4-(((2-(tetrahydro-2H-pyran-4-yl)ethyl)amino)methyl)phenoxy)pyrazine-2-carboxamide; CB-5945, CB5945, CB 5945, ADL-5945, ADL5945, ADL 5945, MK2402, MK 2402, MK-2402,OpRA III; Bevenopran. Grade: 98%. CAS No. 676500-67-7. Molecular formula: C20H26N4O4. Mole weight: 386.45. | |
| Bevonium methylsulfate | Bevonium methylsulfate (CG-201) is an injection that stimulates antibodies to block the pathological forms of hCG that help cancer cells grow and evade the immune system. CG201 was originally created in collaboration with the World Health Organization as a low-cost contraceptive method for developing countries. CG201 is now approved for a Phase I clinical trial in Sweden. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: CG-201; CG 201; CG201; Bevonium methyl sulfate; Piribenzil methyl sulfate; 2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpiperidin-1-ium methyl sulfate. Grade: 98%. CAS No. 5205-82-3. Molecular formula: C23H31NO7S. Mole weight: 465.56. | |
| Bevurogant | Bevurogant is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Synonyms: 8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-({[5-(methanesulfonyl)pyridin-2-yl]methyl}amino)pteridin-7(8H)-one; 8-((S)-1-Cyclopropyl-ethyl)-2-(4-cyclopropyl-6-methyl-pyrimidin-5-yl)-6-[(5-methanesulfonyl-pyridin-2-ylmethyl)-amino]-8H-pteridin-7-one; (S)-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-8-(1-cyclopropylethyl)-6-(((5-(methylsulfonyl)pyridin-2-yl)methyl)amino)pteridin-7(8H)-one. CAS No. 1817773-66-2. Molecular formula: C26H28N8O3S. Mole weight: 532.62. | |
| Bexagliflozin 3-O-β-D-glucuronide | Bexagliflozin 3-O-β-D-glucuronide. Synonyms: (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-3-O-β-D-glucopyranuronosyl-D-glucitol. CAS No. 2495182-19-7. Molecular formula: C30H37ClO13. Mole weight: 641.06. | |
| Bexarotene | Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma. Synonyms: LGD1069; LGD 1069; LGD-1069; LG 100069; Ro 26-445; SR 11247; 3-methyl TTNEB. Bexarotene; US brand name: Targretin. Grade: >98%. CAS No. 153559-49-0. Molecular formula: C24H28O2. Mole weight: 348. | |
| Bexarotene Acyl Glucuronide | Bexarotene Acyl Glucuronide is a glucuronide metabolite of Bexarotene. Synonyms: Bexarotene Acyl-β-D-glucuronide; 1-[4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoate] β-D-Glucopyranuronic Acid. Grade: > 95%. CAS No. 198700-33-3. Molecular formula: C30H36O8. Mole weight: 524.62. | |
| Bexirestrant | Bexirestrant is an orally active ER-α degrader, which can be used for antiestrogen and antineoplastic studies. Synonyms: 2H-1-Benzopyran-7-ol, 3-(3,5-difluorophenyl)-2-(4-((1E)-3-(3-(fluoromethyl)-1-azetidinyl)-1-propen-1-yl)phenyl)-4-methyl-, (2S)-; (S,E)-3-(3,5-difluorophenyl)-2-(4-(3-(3-(fluoromethyl)azetidin-1-yl)prop-1-en-1-yl)phenyl)-4-methyl-2H-chromen-7-ol. Grade: ≥95%. CAS No. 2505067-70-7. Molecular formula: C29H26F3NO2. Mole weight: 477.52. | |
| Bexmarilimab | Bexmarilimab is a humanized monoclonal antibody against Clever-1, a macrophage scavenger receptor known to induce intratumoural immunosuppression. Bexmarilimab has been investigated for the treatment of solid tumors. Synonyms: FP-1305; FP 1305; FP1305. CAS No. 2259301-27-2. | |
| Bexotegrast | Bexotegrast, a potent ανβ6 integrin inhibitor and non-steroidal anti-inflammatory drug (NSAID), can be used to study fibrosis, such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). (Extracted from patent WO2020210404A1, compound 5). Synonyms: Butanoic acid, 4-[(2-methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]-2-(4-quinazolinylamino)-, (2S)-. CAS No. 2376257-44-0. Molecular formula: C27H36N6O3. Mole weight: 492.61. | |
| BEZ235 Tosylate | BEZ235 tosylate is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Synonyms: NVP-BEZ235; BEZ 235 Tosylate; BEZ-235 Tosylate. Grade: >98%. CAS No. 1028385-32-1. Molecular formula: C37H31N5O4S. Mole weight: 641.74. | |
| Bezafibrate Acyl Glucuronide | Bezafibrate Acyl Glucuronide is an impurity of Bezafibrate. Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used for the treatment of hyperlipidaemia. Synonyms: Bezafibrate 1-O-beta-Glucuronide; Benzabate monocelloacyl glucuronide. CAS No. 72156-77-5. Molecular formula: C25H28ClNO10. Mole weight: 537.95. | |
| Bezafibrate Impurity D | Bezafibrate Impurity D is a derivative of Bezafibrate. Synonyms: Bezafibrate Ethyl Ester; 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic Acid Ethyl Ester; Ethyl 2-(4-(2-(4-Chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate. Grade: > 95%. CAS No. 41859-58-9. Molecular formula: C21H24ClNO4. Mole weight: 389.88. | |
| Bezuclastinib | Bezuclastinib, a tyrosine kinase inhibitor, is a potent c-kit and c-kit D816V inhibitor (0.0001| | |
| BF-168 | BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki = 6.4 nM for A1-42). Synonyms: BF 168; 6-(2-fluoroethoxy)-2-(2-(4-methylaminophenil)ethenyl)benzoxazole. Grade: 99%. CAS No. 634911-47-0. Molecular formula: C18H17FN2O2. Mole weight: 312.34. | |
| BF 227 | BF 227 is a candidate used for diagnostic imaging of diseases with amyloid β protein accumulation. Synonyms: BF-227; BF227; 2-[2-(2-dimethylaminothiazol-5-yl-)ethenyl]-6-[2-fluoroethoxy]benzoxazole. CAS No. 845647-80-5. Molecular formula: C16H16FN3O2S. Mole weight: 333.38. | |
| BF 2649 | Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patients. Uses: The treatment of narcolepsy with or without cataplexy. Synonyms: BF 2649; BF2649; BF-2649; pitolisant hydrochloride; Wakix; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine hydrochloride. CAS No. 903576-44-3. Molecular formula: C17H27Cl2NO. Mole weight: 332.309. | |
| BF738735 | A potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor. Synonyms: 1436383-95-7; BF738735; 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol; CHEMBL2407818; 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol; BF 738735; C21H19FN4O3S; GLXC-25537; BDBM50492527; HY-U00426; MFCD31619316; AKOS040742416; DA-61637; SY125659; WS-01993; CS-0035356; W15611; 2-Fluoro-4-[2-methyl-8-[[3-(methylsulfonyl)benzyl]amino]-3-imidazo[1,2-a]pyrazinyl]phenol; 2-fluoro-4-(8-{[(3-methanesulfonylphenyl)methyl]amino}-2-methylimidazo[1,2-a]pyrazin-3-yl)phenol. Grade: ≥98%. CAS No. 1436383-95-7. Molecular formula: C31H57N5O9. Mole weight: 643.8. | |
| BF844 | BF844 is a CLRN1N48K stabilizer that can attenuate progressive hearing loss and deafness in an Usher syndrome type III (USH3) mouse model. Uses: Hearing loss therapy. Synonyms: BioFocus 844; BioFocus844; BioFocus-844; BF844; BF-844; BF 844; 4-Chloro-α,α-dimethyl-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine-1-ethanol. Grade: 98%. CAS No. 1404506-35-9. Molecular formula: C21H19ClN4O. Mole weight: 378.85. | |
| BFCAs-1 | BFCAs-1 is a polyamino polycarboxylic bifunctional chelating agent, which has a broad range of applications in chemistry, biology and medicine and diagnostic imaging. Grade: >98%. CAS No. 585531-74-4. Molecular formula: C32H60N4O8. Mole weight: 628.84. | |
| BFF 122 | BFF 122 is a potent and selective inhibitor of kynurenine aminotransferase II (IC50 = 1 μM and >30 μM for KAT II and KAT I respectively). Synonyms: BFF122; BFF 122; BFF-122; BF5; (S)-9-(4-Amino-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid. Grade: 99%. CAS No. 1152314-49-2. Molecular formula: C17H19FN4O4. Mole weight: 362.36. | |
| BFH772 | BFH772, a structure analogue of BAW2881, was highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM, however, lost 500-fold potency on FLK-1, FLT-1, and FLT-4. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM. Synonyms: 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-1-naphthalenecarboxamide; BFH-772; BFH 772; BFH772; 1-Naphthalenecarboxamide, 6-((6-(hydroxymethyl)-4-pyrimidinyl)oxy)-N-(3-(trifluoromethyl)phenyl)-. CAS No. 890128-81-1. Molecular formula: C23H16F3N3O3. Mole weight: 439.4. | |
| BG45 | BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively. Synonyms: BG45; BG-45; BG 45. Grade: 98%. CAS No. 926259-99-6. Molecular formula: C11H10N4O. Mole weight: 214.22. | |
| b-Galactosyl 1-3 N-acetyl galactosamine methyl glycoside | b-Galactosyl 1-3 N-acetyl galactosamine methyl glycoside is a sophisticated compound, functioning as an artfully engineered synthetic glycoside. Thereby, it orchestrates nuanced manipulation of cellular processes instrumental in compound administration, focused therapeutics, or malady identification. Synonyms: Methyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-b-D-galactopyranoside; β-Galactosyl 1-3 N-acetyl galactosamine methyl glycoside; N-Acetyl-3-O-beta-D-galactopyranosyl-beta-D-galactosamine methyl glycoside; N-Acetyl-3-O-β-D-galactopyranosyl-β-D-GA. Grade: ≥98%. CAS No. 88274-25-3. Molecular formula: C15H27NO11. Mole weight: 397.38. | |
| b-Galactosylceramides from bovine brain | b-Galactosylceramides from bovine brain, derived from the ample tissues of bovine brain, stand as naturally occurring glycosphingolipids. Their intrinsic attributes have unveiled a realm of possibilities in biomedical research, particularly delving into the intricate realm of immune responses and tumor development. Synonyms: Ceramide b-D-galactosides; Cerebrosides. CAS No. 85305-88-0. Molecular formula: C48H93NO9. Mole weight: 828.3. | |
| BGB-283 | BGB-283 is a selective Epidermal growth factor receptor and Proto oncogene protein b raf inhibitor under the development of BeiGene. BGB-283 shows antitumor activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 can inhibit B-RAFV600E-activated ERK phosphorylation and cell proliferation. In vivo, BGB-283 can lead to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. Phase I clinical trials for the treatment of solid tumours are on-going. Uses: Solid tumours. Synonyms: UNII-8762XZS5ZF; 8762XZS5ZF; BGB-283; BGB 283; BGB283; Beigene-283; Beigene283; Beigene 283; Lifirafenib; Compound 2.2b; Beigene-283; GTPL8958; 5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one. Grade: 98%. CAS No. 1446090-77-2. Molecular formula: C25H17F3N4O3. Mole weight: 478.31. | |
| BGC-20-1531 | BGC-20-1531 is a high-affinity and selective EP4 antagonist (Ki = 3 nM). BGC-20-1531 has the potential for the treatment of migraine headache. Synonyms: BGC 20-1531; BGC201531; BGC-201531; BGC 201531; GTPL3380; GTPL-3380; GTPL 3380; AP-1531; AP1531; AP1531. Grade: >98%. CAS No. 1186532-61-5. Molecular formula: C26H23N2NaO6S. Mole weight: 514.53. | |
| BGC-20-1531 free base | BGC-20-1531 is a selective EP4 receptor antagonist with a pKB of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache. Synonyms: BGC-201531; PGN 1531 free base; 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide. Grade: 98%. CAS No. 736183-35-0. Molecular formula: C26H24N2O6S. Mole weight: 492.54. | |
| BGC 20-1531 hydrochloride | BGC 20-1531 hydrochloride is a potent and selective EP4 antagonist, which exhibits <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors. It has high affinity and selective with Ki of 3 nM for EP4 antagonist. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA. It also reverses PGE2-induced vasorelaxation with Kb of 15.85 nM in human middle cerebral and middle meningeal arterial rings. Synonyms: BGC20-1531 HCl; BGC20-1531 hydrochloride; BGC20-1531; BGC 20-1531; BGC-20-1531; BGC201531; BGC 201531; BGC-201531; PGN 1531; PGN-1531; PGN1531. Grade: ≥98%. CAS No. 1962928-26-2. Molecular formula: C26H24N2O6S·HCl. Mole weight: 529. | |
| BGC 20-761 | BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). BGC 20-761 was shown to reverse the amnesic effects of scopolamine and enhance memory consolidation in a rat model. Synonyms: BGC-20-761; BGC 20 761; 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine; N,N-Dimethyl-2-(5-methoxy-2-phenylindol-3-yl)ethylamine. Grade: ≥98% by HPLC. CAS No. 17375-63-2. Molecular formula: C19H22N2O. Mole weight: 294.39. | |
| BGC-638 | BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. Synonyms: BGC 638; BGC638; CB300638; CB-300638; D-Glutamic acid, N-(4-(2-propyn-1-yl((6S)-4,6,7,8-tetrahydro-2-methyl-4-oxo-3H-cyclopenta(g)quinazolin-6-yl)amino)benzoyl)-L-gamma-glutamyl-. CAS No. 416852-27-2. Molecular formula: C32H33N5O9. Mole weight: 631.64. | |
| BGC-945 | BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. BGC 945 has low affinity for the widely expressed reduced-folate carrier (RFC). BGC 945 selectively inhibits thymidylate synthase in α-FR-overexpressing tumors and should cause minimal toxicity to humans at therapeutic doses. Synonyms: Idetrexed; ONX-0801; N-[4-[2-Propynyl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; (R)-2-((S)-4-carboxy-4-(4-(((S)-2-(hydroxymethyl)-4-oxo-4,6,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)(prop-2-yn-1-yl)amino)benzamido)butanamido)pentanedioic acid. Grade: ≥95%. CAS No. 501332-69-0. Molecular formula: C32H33N5O10. Mole weight: 647.63. | |
| b-Gentiobiose octaacetate | b-Gentiobiose octaacetate is a biomedical compound employed extensively in drug development and research, predominantly recognized as a safeguarding tool for delicate pharmaceuticals. This compound remarkably aids drug delivery and augments stability. Moreover, its application extends to the investigation of ailments such as cancer, diabetes and neurodegenerative disorders, thereby effectively unraveling their intricate mechanisms and potential researchs. Synonyms: 1,2,3,4-Tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-b-D-glucopyranose; β-D-Glucopyranose, 6-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-, 1,2,3,4-tetraacetate; Gentiobiose octaacetate; β-D-Glucopyranose, 6-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-, tetraacetate; β-Gentiobiose octaacetate. CAS No. 4613-78-9. Molecular formula: C28H38O19. Mole weight: 678.59. | |
| BGJ-398 | BGJ398, also known as NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Synonyms: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea; NVPBGJ398; NVPBGJ 398; NVPBGJ-398; BGJ398; BGJ-398; BG J398; Infigratinib. Grade: 0.98. CAS No. 872511-34-7. Molecular formula: C26H31Cl2N7O3. Mole weight: 560.48. | |
| b-Glucosylglycerol 2,3,4,6-tetraacetate | b-Glucosylglycerol 2,3,4,6-tetraacetate, a remarkable compound, exhibits immense potential as an antidiabetic agent. In the realm of diabetes management, this prodigious specimen reigns, adeptly regulating blood glucose levels and fostering insulin sensitivity enhancement. Beyond its primary scope, it gracefully unveils itself as a viable therapeutic alternative for diverse metabolic afflictions. Synonyms: 2-(Tetraacetylglucosido)glycerol; 2-Hydroxy-1-(hydroxymethyl)ethyl b-D-glucopyranoside 2,3,4,6-tetraacetate; 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl glycerol; Glycerol, 2-(tetraacetylglucosido)-; β-D-Glucopyranoside, 2-hydroxy-1-(hydroxymethyl)ethyl, 2,3,4,6-tetraacetate. CAS No. 157024-67-4. Molecular formula: C17H26O12. Mole weight: 422.38. | |
| BGP-15 | BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively. Uses: Enzyme inhibitors. Synonyms: BGP15; BGP 15; 3-Pyridinecarboximidamide, N-(2-hydroxy-3-(1-piperidinyl)propoxy)-, hydrochloride (1:2). Grade: >98%. CAS No. 66611-37-8. Molecular formula: C20H40N4O3S3. Mole weight: 351.27. | |
| BGT226 | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability. Synonyms: BGT-226; BGT 226; BGT-226 free base; BGT226 free base; NVP-BGT226; 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-2H-imidazo[4,5-c]quinolin-2-one. Grade: 98%. CAS No. 915020-55-2. Molecular formula: C32H29F3N6O6. Mole weight: 534.54. | |
| BH3I-1 | BH3I-1 is a cell-permeable inhibitor that targets Bcl-2 family protein. It inhibits the binding of BH3 peptides to Bcl-xL and induces apoptosis of Bcl-xL expressing cells. Synonyms: BH3I-1; BH 3I-1; BH-3I-1; BH3I1; BH 3I1; BH-3I1. 2-[(5E)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-methylbutanoic acid. Grade: 99%. CAS No. 300817-68-9. Molecular formula: C15H14BrNO3S2. Mole weight: 400.31. | |
| BHPI | BHPI is an antagonist of estrogen receptor α (ERα), for it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor. Uses: An antagonist of estrogen receptor α (erα). Synonyms: 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one. Grade: ≥95%. CAS No. 56632-39-4. Molecular formula: C21H17NO3. Mole weight: 331.4. | |
| BHQ-1-dT CE Phosphoramidite | BHQ-1-dT, a widely utilized reagent in the biomedicine realm, remains pertinent for nucleic acid detection and DNA sequencing. Its potential significance surfaces in disease and genetic disorder determination alongside viral load monitoring in infectious cases. From a development standpoint, BHQ-1-dT fosters therapeutic targeting of nucleic acids. Synonyms: BHQ-1-dT; HCQ-12-dT Phosphoramidite; 5'-Dimethoxytrityloxy-5-[(N-4''-carboxyethyl-4''-(N-ethyl)-4'-(2-Nitro-4-toluyldiazo)-2'-methoxy-5'-methyl-azobenzene)-aminohexyl-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; BHQ-1-dT Amidite. Grade: ≥95%. Molecular formula: C74H89N12O14P. Mole weight: 1401.56. | |
| BHQ-2-dT | BHQ-2-dT plays a critical role in propelling PCR probes and hybridization assays to new heights of detection, this modified nucleoside serves as a beacon for identifying viral pathogens, genetic diseases, and cancer biomarkers. With its distinctive fluorescent abilities, molecular matching is taken to the next level of precision and accuracy, boosting sensitivity like never before. Synonyms: HCQ-2-dT Phosphoramidite; BHQ-2-dT CE Phosphoramidite; 5'-Dimethoxytrityloxy-5-[(N-4''-carboxyethyl-4''-(N-ethyl)-4'-(4-Nitro-phenyldiazo)-2'-methoxy-5'-methoxy-azobenzene)-aminohexyl-3-acrylimido]-2'-deoxyUridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; BHQ-2-dT Phosphoramidite; BHQ-2-dT Amidite. Grade: ≥95%. CAS No. 1415097-34-5. Molecular formula: C73H87N12O15P. Mole weight: 1403.53. | |
| B-HT 920 dihydrochloride | Talipexole is a D2 dopamine receptor agonist, displaying anti-Parkinsonian activity. Uses: A dopamine agonist, also an α2-adrenergic agonist. Synonyms: Talipexole; B-HT 920, B-HT-920, B-HT920, Talipexole HCl, Talipexole dihydrochloride, Domnin6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine; dihydrochloride; 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride. Grade: ≥98%. CAS No. 36085-73-1. Molecular formula: C10H15N3S; 2HCl. Mole weight: 282.23. | |
| B-HT 933 dihydrochloride | B-HT 933 dihydrochloride is a selective α2-adrenoceptor agonist displaying 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor. B-HT 933 decreases blood pressure and cardiac output in cats, and exhibits antinociceptive activity in mice. Uses: Adrenergic alpha-agonists. Synonyms: B-HT 933 dihydrochloride; B-HT933 dihydrochloride; B-HT-933 dihydrochloride; Azepexole hydrochloride; Azepexole dihydrochloride; 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 36067-72-8. Molecular formula: C9H15N3O.2HCl. Mole weight: 254.16. | |
| B-HT 958 dihydrochloride | B-HT 958 dihydrochloride is a dopamine D2 receptor agonist and an α2-adrenoceptor partial agonist. Synonyms: B-HT 958 dihydrochloride; B-HT958 dihydrochloride; B-HT-958 dihydrochloride; 4H-Thiazolo(4,5-d)azepin-2-amine, 5,6,7,8-tetrahydro-6-((4-chlorophenyl)methyl)-, dihydrochloride; 2-Amino-6-(4-chlorobenzyl)-4,5,7,8-tetrahydro-6H-thiazolo(5,4-d)azepine dihydrochloride; 5,6,7,8-Tetrahydro-6-((4-chlorophenyl)methyl)-4H-thiazolo(4,5-d)azepin-2-amine dihydrochloride. Grade: 99%. CAS No. 36085-44-6. Molecular formula: C14H16ClN3S.2HCl. Mole weight: 366.74. | |
| BI 01383298 | BI01383298 is a potent and selective inhibitor of human SLC13A5 (Na+/citrate co-transporter) with IC50 of 56 nM in HEK cells overexpressing hSLC13A5. BI01383298 is highly selective over other family members and other transporters with >1000-fold selectivity over others. Synonyms: 1-[(3,5-Dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide. Grade: ≥98%. CAS No. 2227549-00-8. Molecular formula: C19H19Cl2FN2O3S. Mole weight: 445.34. | |
| BI-0474 | BI-0474 is a potent KRAS G12C inhibitor with IC50 value of 7.0 nM. Synonyms: BI 0474; BI0474. CAS No. 2750570-55-7. Molecular formula: C30H37N9O2S. Mole weight: 587.74. | |
| B I09 | B I09 is a cell permeable IRE-1 RNase inhibitor (IC50 = 1.23 μM) that blocks IRE-1/XBP1 pathway. B I09 exhibits an inhibitory effect on growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model. Uses: Potential treatment of cll. Synonyms: B-I09; B I09; BI09; 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one. Grade: ≥98% by HPLC. CAS No. 1607803-67-7. Molecular formula: C16H17NO5. Mole weight: 303.31. | |
| BI-1347 | BI-1347 is small molecule CDK8 inhibitor with IC50 of 1.1 nM. BI-1347 was shown to enhance NK-cell activity and promote tumor surveillance. Synonyms: BI 1347; BI1347. CAS No. 2163056-91-3. Molecular formula: C22H20N4O. Mole weight: 356.42. | |
| BI-1408 | BI-1408 is a potent γ-secretase modulator with an IC50 of 0.04 μM for Aβ42. Synonyms: N-[(5R)-1-Ethyl-4,5,6,7-tetrahydro-1H-indazol-5-yl]-8-(4-fluoro-2-methylphenyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine; [1,2,4]Triazolo[1,5-a]pyridin-2-amine, N-[(5R)-1-ethyl-4,5,6,7-tetrahydro-1H-indazol-5-yl]-8-(4-fluoro-2-methylphenyl)-. Grade: ≥90%. CAS No. 2231075-94-6. Molecular formula: C22H23FN6. Mole weight: 390.46. | |
| BI-167107 | BI-167107 is a β-arrestin-biased D2R agonist that binds to β2 adrenergic receptor (β2AR) with a dissociation constant Kd of 84 pM. Synonyms: BI 167107; BI167107. Grade: 98%. CAS No. 1202235-68-4. Molecular formula: C21H26N2O4. Mole weight: 370.4. | |
| BI-187004 | BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor. BI187004 had a positive impact on multiple cardiovascular and metabolic risk factors associated with metabolic syndrome, which differentiates it from other classes of type 2 diabetes drugs. Synonyms: BI 187004; VTP-34072; VTP 34072; VTP34072; (4AR,9aS)-1-(1H-benzo[d]imidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-6-carbonitrile. CAS No. 1303515-32-3. Molecular formula: C21H18N4O. Mole weight: 342.40. | |
| BI 224436 | BI 224436 is a novel HIV-1 non-catalytic-site integrase inhibitor; has antiviral EC50s of <15 nM against different HIV-1 laboratory strains and cellular cytotoxicity of>90 μM. Synonyms: BI-224436; BI 224436; BI224436. Grade: >98%. CAS No. 1155419-89-8. Molecular formula: C27H26N2O4. Mole weight: 442.51. | |
| BI-2493 | BI-2493 is a potent pan-KRAS inhibitor that has the potential for the treatment of cancer. Synonyms: BI 2493; BI2493. CAS No. 2937344-16-4. Molecular formula: C24H27N7OS. Mole weight: 461.58. | |
| BI-2536 | BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. Synonyms: BI2536; BI 2536; (R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide. Grade: 98%. CAS No. 755038-02-9. Molecular formula: C28H39N7O3. Mole weight: 521.65. | |
| BI-2852 | BI-2852 is a KRAS inhibitor. It blocks the interaction of GEF, GAP and effectors with KRAS, thereby inhibiting downstream signal transduction and producing anti-proliferative effects in KRAS mutant cells. Synonyms: BI-2852; 2375482-51-0; CHEMBL4750445; (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one; (3S)-5-hydroxy-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1H-indol-3-yl]-2,3-dihydroisoindol-1-one; F0K; SCHEMBL24414712; BCP31539; EX-A4793; BDBM50549225; s8959; AKOS040732592; BI2852; BI 2852; MS-29593; HY-126247; CS-0100975; A934943; (S)-5-Hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl)-1H-indol-3-yl)isoindolin-1-one; (S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one. Grade: ≥98% by HPLC. CAS No. 2375482-51-0. Molecular formula: C31H28N6O2. Mole weight: 516.6. | |
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