BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BI-2865 | BI-2865 is a none-covalent pan-KRAS Inhibitor. It inhibits tumor growth in mice bearing KRAS G12C, G12D, G12V. Synonyms: BI 2865; BI2865. CAS No. 2937327-93-8. Molecular formula: C23H27N7O2S. Mole weight: 465.57. |  |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Synonyms: BI 3406; BI3406. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.5. | |
| BI-3802 | BI-3802 is a highly potent BCL6 degrader that inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. It induces BCL6 polymerization and degradation via E3 ligase SIAH1, showing antitumor activity. Grade: ≥98% by HPLC. CAS No. 2166387-65-9. Molecular formula: C24H29ClN6O3. Mole weight: 484.98. | |
| BI-3812 | BI-3812 is potent and efficacious BCL6 inhibitor. It inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM. The high potency and good permeability properties of BI-3812 make this molecule a very good cellular probe compound for testing hypotheses around BCL6 biology. The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Synonyms: BI-3812; 2166387-64-8; CHEMBL4755229; 1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide; SCHEMBL20284237; AMY16876; BCP31903; EX-A2841; BDBM50546197; s8735; AKOS040741329; SB40386; BI 3812; BI3812; AC-31571; MS-30157; HY-111381; CS-0040299; A935150; EN300-22885148; Z3417458909; 1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide; 1-[5-Chloro-4-({8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-1,2-dihydro-6-quinolinyl}amino)-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide; 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide. Grade: ≥98%. CAS No. 2166387-64-8. Molecular formula: C26H32ClN7O5. Mole weight: 558.03. | |
| BI-4020 | BI-4020 is an orally active EGFR inhibitor. Synonyms: BI 4020; BI4020. CAS No. 2573869-33-5. Molecular formula: C30H38N8O2. Mole weight: 542.68. | |
| BI-409306 | BI-409306 is a potent and selective inhibitor of phosphodiesterase 9A (PDE9A). BI-409306 has been researched as a candidate for the treatment of schizophrenia. Uses: Phosphodiesterase inhibitors. Synonyms: BI 409306; BI409306; SUB 166499; Osoresnontrine. CAS No. 1189767-28-9. Molecular formula: C16H17N5O2. Mole weight: 311.34. | |
| BI-44847 | BI-44847 is a synthetic bio-active chemical had been in phase II clinical trials for the treatment of type 2 diabetes. Uses: Sodium-glucose transporter 2 inhibitors. Synonyms: BI-44847; BI 44847; BI44847; UNII-43WJ33399D; beta-D-Glucopyranoside,4-((2-fluoro-4-methoxyphenyl)methyl)- 5-methyl-1-(1-methylethyl)-1H-pyrazol-3-yl. Grade: ≥98%. CAS No. 421592-30-5. Molecular formula: C21H29FN2O7. Mole weight: 440.46. | |
| BI-4834 | BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. Synonyms: BI4834; BI 4834. Grade: >98%. CAS No. 876371-13-0. Molecular formula: C21H42N4O3S3. Mole weight: 593.76. | |
| BI 6015 | BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that suppresses expression of known HNF4α target genes. BI 6015 produces cytotoxicity in a range of tumor cell lines, including human hepatocellular carcinoma. Synonyms: BI6015; BI 6015; BI-6015. 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole. Grade: ≥98% by HPLC. CAS No. 93987-29-2. Molecular formula: C15H13N3O4S. Mole weight: 331.35. | |
| BI605906 | BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. It not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation. Uses: Bi605906 not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in ikkβ that trigger its activation. Synonyms: BI605906; BI-605906; BI 605906; 3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide. Grade: >98 %. CAS No. 960293-88-3. Molecular formula: C17H22F2N4O3S2. Mole weight: 432.51. | |
| BI671800 | BI671800 is a CRTH2 antagonist. It is used to treat patients with asthma. It is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy. Uses: Bi671800 is used to treat patients with asthma. Synonyms: AP-761; AP 761; AP761; 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-; 2-(4,6-Bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)benzyl)pyrimidin-5-yl)acetic acid; BI-671800; BI 671800; BI671800. Grade: >98%. CAS No. 1093108-50-9. Molecular formula: C25H26F3N5O3. Mole weight: 501.51. | |
| BI-6C9 | BI-6C9 ( N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide) is a tBid inhibitor that possesses antiapoptotic properties. Bid plays an essential role in matrine-induced AIF translocation. BI-6C9 also blocked matrine-induced AIF translocation detected by confocal microscopy. Bid inhibitor BI-6C9 was applied to confirm the essential role of Bid in cell death induced by matrine. Synonyms: N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide. Grade: ≥98%. CAS No. 791835-21-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.6. | |
| BI-7273 | BI-7273 is a potent BRD9 bromodomain inhibitor (Ki = 15.4 nM; IC50=19 nM). BI-7273 structurally related BRD7 bromodomain (IC50 = 117 nM) without effect against the BRD2 and BRD4 bromodomain or a panel of kinases. BI-7273 has potential for use in treating acute myeloid leukemia according to a study in vitro (EC50 = 1.4 μM). Uses: A potent brd9 bromodomain inhibitor for the treatment of leukemia. Synonyms: 4-{4-[(dimethylamino)methyl]-2,6-dimethoxyphenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one; 4-(4-((Dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; 2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-; BI7273; BI 7273. Grade: >98%. CAS No. 1883429-21-7. Molecular formula: C20H23N3O3. Mole weight: 353.41. | |
| BI 749327 | BI 749327 is a potent, selective and orally available TRPC6 inhibitor with IC50 of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. Synonyms: (4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone. Grade: 99%. CAS No. 2361241-23-6. Molecular formula: C23H21F3N4O2. Mole weight: 442.43. | |
| BI 78D3 | BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) with > 100 fold selectivity over p38α and no effect on mTOR and PI-3K. BI 78D3 inhibits JNK interacting protein 1 (JIP1) binding to JNK (IC50 = 500 nM) and prevents JNK substrate phosphorylation. It blocks JNK-dependent Con A-induced liver damage and also restores insulin sensitivity in a mouse model of type II diabetes. Synonyms: JNK Inhibitor X; BI-78D3; BI78D3; BI 78D3; 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one. Grade: ≥99% by HPLC. CAS No. 883065-90-5. Molecular formula: C13H9N5O5S2. Mole weight: 379.37. | |
| BI-847325 | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Synonyms: BI-847325; BI 847325; BI847325. Grade: 98%. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.56. | |
| BI-882370 | BI-882370 is a highly potent, selective, orally active RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. BI-882370 is a potent and selective RAF inhibitor uniquely binding to the DFG-out conformation, whereas marketed BRAF inhibitors occupy the DFG-in conformation. BI-882370 inhibits proliferation of human BRAF-mutant melanoma cells with 100× higher potency (1-10 nmol/L) than vemurafenib. BI-882370 may provide an improved therapeutic window, enabling more pronounced and longer-lasting pathway suppression and thus resulting in improved efficacy. Synonyms: BI882370; BI 882370. Grade: ≥95%. CAS No. 1392429-79-6. Molecular formula: C28H33F2N7O2S. Mole weight: 569.7. | |
| BI 894999 | BI 894999 is a potent and selective BET inhibitor. BI 894999 targets super-enhancer-regulated oncogenes and other lineage-specific factors, which are involved in the maintenance of the disease state. Synonyms: BI-894999; BI894999; BRD4 Inhibitor-10. CAS No. 1660117-38-3. Molecular formula: C25H27N5O2. Mole weight: 429.51. | |
| BI 9321 | BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist with IC50 of 1.2 μM. It is also selectively binds the PWWP1 domain of NSD3 with Kd of 166 nM. BI 9321 antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells. High selectivity of BI-9321 was confirmed using in vitro assays and quantitative chemical proteomics. Cellular target engagement was confirmed with FRAP (Fluorescence Recovery After Photobleaching) and BRET (Bioluminescence Resonance Energy Transfer) at 1 μM. Synonyms: (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride. Grade: ≥98%. Molecular formula: C22H21FN4·3HCl. Mole weight: 469.81. | |
| BI-9321 | BI-9321 is a potent, selective and cellular active antagonist of nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain with a Kd of 166 nM. BI-9321 has no activity against NSD2-PWWP1 and NSD3-PWWP2, and specifically disrupts histone interactions in the NSD3-PWWP1 domain, with an IC50 of 1.2 μM in U2OS cells. Synonyms: 1-{4-[5-(7-Fluoro-4-quinolinyl)-1-methyl-1H-imidazol-4-yl]-3,5-dimethylphenyl}methanamine; Benzenemethanamine, 4-[5-(7-fluoro-4-quinolinyl)-1-methyl-1H-imidazol-4-yl]-3,5-dimethyl-. Grade: ≥95%. CAS No. 2387510-86-1. Molecular formula: C22H21FN4. Mole weight: 360.43. | |
| BI-9564 | BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively), with selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Synonyms: 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; BI-9564; BI 9564; BI9564. CAS No. 1883429-22-8. Molecular formula: C20H23N3O3. Mole weight: 353.42. | |
| BI-9627 hydrochloride | Sodium-hydrogen exchanger isoform 1 (NHE1) is a ubiquitously expressed transmembrane ion channel. BI-9627 hydrochloride is sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor. Synonyms: BIX HCl. Grade: 98%. CAS No. 1422252-46-7. Molecular formula: C16H20ClF3N4O2. Mole weight: 392.8. | |
| BI 99179 | BI 99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM. Synonyms: BI-99179; BI99179; (1R,3S)-N-(4-(Benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentanecarboxamide. Grade: 99%. CAS No. 1291779-76-4. Molecular formula: C23H25N3O3. Mole weight: 391.46. | |
| BI 99990 | BI 99990 is a negative control compound of the active enantiomer BI 99179. Synonyms: BI-99990; BI99990; (1S,3R)-N-(4-(Benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentanecarboxamide. Grade: 98%. CAS No. 1338468-86-2. Molecular formula: C23H25N3O3. Mole weight: 391.46. | |
| BIA | BIA is an inhibitor of the interaction between TMBIM6 and mTORC2. Synonyms: TMBIM6 antagonist BIA; (E)-1-(2-Aminophenyl)-3-(3-nitrophenyl)prop-2-en-1-one. Grade: 99%. CAS No. 134271-74-2. Molecular formula: C15H12N2O3. Mole weight: 268.27. | |
| BIA10-2474 | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide; UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grade: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| Biafungin acetate | Biafungin acetate is a next-generation, broad-spectrum, and long-lasting echinocandin. It shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. Synonyms: Rezafungin acetate; CD101 acetate; CD-101 acetate; SP-3025 acetate. CAS No. 1631754-41-0. Molecular formula: C65H88N8O19. Mole weight: 1285.44. | |
| Bialamicol hydrochloride | Bialomicol is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: Bialamicol Hydrochloride; Bialamicol hydrochloride [USAN]; CAM 807; CAM-807; Camoform hydrochloride; CI 301; CI301; CI-301; NSC 6386; PAA 701 dihydrochloride; PAA-701; PAA701 dihydrochloride; SN 6771 dihydrochloride; UNII-VIQ3X36S8C; 2-(diethylaminomethyl)-4-[3-(diethylaminomethyl)-4-hydroxy-5-prop-2-enylphenyl]-6-prop-2-enylphenol; dihydrochloride. Grade: ≥98%. CAS No. 3624-96-2. Molecular formula: C28H42Cl2N2O2. Mole weight: 509.556. | |
| Bianntennary N-linked core pentasaccharide | Bianntennary N-linked core pentasaccharide is a pivotal compound assuming a momentous function in the examination of glycosylation motifs and their inherent physiological mechanisms. Through its utilization, one may delve into the intricate biosynthetic pathways and alterations conversant with N-linked glycans. Synonyms: GlcNAcβ1-2Manα1-6Man3-1Manα2-1βGlcNAc. Grade: ≥95%. Molecular formula: C34H58N2O26. Mole weight: 910.82. | |
| Biapenem | Biapenem is a carbapenem antibiotic with in vitro activity against anaerobes. Synonyms: Omegacin; Biapenern; L-627; L 627; L627. Grade: 98%. CAS No. 120410-24-4. Molecular formula: C15H18N4O4S. Mole weight: 350.39282. | |
| BIBB 515 | 2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. It is concluded that the lipid-lowering effect of BIBB 515 is mainly the result of an inhibition of LDL production rather than due to an increase in LDL catabolism. OSC inhibitors may offer a novel approach for lipid-lowering therapy. Synonyms: BIBB-515; BIBB515. Grade: ≥98%. CAS No. 156635-05-1. Molecular formula: C22H21ClN2O2. Mole weight: 380.9. | |
| Bibenzyl | 1,2-Diphenylethane is a kind of widely used aromatic hydrocarbon compound. Synonyms: 2-phenylethylbenzene. CAS No. 103-29-7. Molecular formula: C14H14. Mole weight: 182.26. | |
| BIBF0775 | BIBF0775 is an inhibitor of transforming growth factor beta receptor I (TGFβRI) with an IC50 of 34 nM. Synonyms: (Z)-N-Ethyl-N-Methyl-2-Oxo-3-(Phenyl((4-(Piperidin-1-Ylmethyl)Phenyl)Amino)Methylene)Indoline-6-Carboxamide. Grade: ≥98% by HPLC. CAS No. 334951-90-5. Molecular formula: C31H34N4O2. Mole weight: 494.6. | |
| BIBR 1532 | BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length. Synonyms: BIBR1532; BIBR-1532; BIBR 1532. Grade: >98%. CAS No. 321674-73-1. Molecular formula: C21H17NO3. Mole weight: 331.36. | |
| BIBS 39 | BIBS 39, a nonpeptide angiotensin II receptor antagonist, has been found to exhibit potential antihypertensive activity in rat. It has been already discontinued against hypertension. Uses: Bibs 3 is a nonpeptide angiotensin ii receptor antagonist that has been found to exhibit potential antihypertensive activity in rat. Synonyms: BIBS-39; BIBS39; BIBS 39.; CHEMBL130896; 2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid; AC1L2ZGG. Grade: 98%. CAS No. 133085-33-3. Molecular formula: C32H36N4O3. Mole weight: 524.65. | |
| BIBU 1361 dihydrochloride | BIBU 1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with ~ 100-fold lower potency than ErbB2 (IC50 = 290 nM) and selectivity over a range of other related tyrosine kinases (IC50 > 10 μM). BIBU 1361 blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Synonyms: BIBU 1361 dihydrochloride; BIBU1361 dihydrochloride; BIBU-1361 dihydrochloride; N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride. Grade: ≥97% by HPLC. CAS No. 793726-84-8. Molecular formula: C22H27ClFN7.2HCl. Mole weight: 516.87. | |
| BIBX 1382 dihydrochloride | BIBX 1382 dihydrochloride is a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with > 1000-fold lower potency than ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). BIBX 1382 inhibits Lassa, Ebola and Marburg viruses. Synonyms: BIBX 1382 dihydrochloride; BIBX1382 dihydrochloride; BIBX-1382 dihydrochloride; Falnidamol Dihydrochloride; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diamine dihydrochloride. Grade: ≥97% by HPLC. CAS No. 1216920-18-1. Molecular formula: C18H19ClFN7.2HCl. Mole weight: 460.77. | |
| Bicalutamide | Bicalutamide is a non-steroidal androgen receptor (AR) antagonist with IC50 of 0.16 μM. Synonyms: ICI 176334; ICI-176334; ICI176334; Abbreviation: CDX. US brand name: Casodex. Foreign brand name: Cosudex. Grade: >98%. CAS No. 90357-06-5. Molecular formula: C18H14F4N2O4S. Mole weight: 430.37. | |
| Bicalutamide EP Impurity E | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity E; (2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(RS)-(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide. Grade: ≥95%. Molecular formula: C18H14F4N2O3S. Mole weight: 414.38. | |
| Bicalutamide EP Impurity F | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity F; (2SR)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(RS)-(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide. Grade: ≥95%. Molecular formula: C18H14F4N2O3S. Mole weight: 414.38. | |
| Bicalutamide EP Impurity H | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity H; (2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-[(4-fluorophenyl)sulfonyl]-3-hydroxy-2-methylpropanamide; N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-[(4-fluorophenyl)sulfonyl]-3-hydroxy-2-methylpropanamide. Grade: ≥95%. CAS No. 2512198-58-0. Molecular formula: C18H14F4N2O4S. Mole weight: 430.37. | |
| Bicalutamide EP Impurity K | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity K; (2R,2'S)-3,3'-Sulfonylbis[N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide]; (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(((R)-3-((4-cyano-3-(trifluoromethyl)phenyl)amino)-2-hydroxy-2-methyl-3-oxopropyl)sulfonyl)-2-hydroxy-2-methylpropanamide. Grade: ≥95%. Molecular formula: C24H20F6N4O6S. Mole weight: 606.49. | |
| Bicalutamide EP Impurity L | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity L; (2RS,2'RS)-3,3'-Sulfonylbis[N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide]; 3,3'-Sulfonylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide). Grade: ≥95%. CAS No. 2711603-77-7. Molecular formula: C24H20F6N4O6S. Mole weight: 606.49. | |
| Bicalutamide EP Impurity M | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity M; (2RS)-3-[(4-Fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoic acid; 3-[(4-Fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoic acid; (+/-)-3-((4-Fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanoic acid. Grade: >95%. CAS No. 151262-57-6. Molecular formula: C10H11FO5S. Mole weight: 262.26. | |
| Bicalutamide Epoxide Impurity | Bicalutamide Epoxide Impurity is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide. Synonyms: N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide; N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide; (±)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide; 2-Methyloxirane-2-carboxylic acid N-(4-Cyano-3-trifluor. Grade: > 95%. CAS No. 90357-51-0. Molecular formula: C12H9F3N2O2. Mole weight: 270.21. | |
| Bicalutamide Glucoronide | Bicalutamide Glucuronide is a metabolite of the non-steroidal peripherally active antiandrogen Bicalutamide. Synonyms: Bicalutamide O-β-D-Glucuronide; 2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1-[[(4-fluorophenyl)sulfonyl]methyl]-1-methyl-2-oxoethyl β-D-Glucopyranosiduronic Acid; Casodex Glucuronide; (2S,3S,4S,5R,6S)-6-((1-((4-Cyano-3-(trifluoromethyl)phenyl)amino)-3-((4-fluorophenyl)sulfonyl)-2-methyl-1-oxopropan-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Grade: >95%. CAS No. 151262-59-8. Molecular formula: C24H22F4N2O10S. Mole weight: 606.51. | |
| Bicalutamide Impurity 1 | Bicalutamide Impurity 1 is an impurity of Bicalutamide. Synonyms: N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyl-2-Propenamide; 2-Methyl-N-[(4-cyano-3-trifluoromethyl)phenyl]-propenamide; N-Methacryloyl-4-cyano-3-trifluoromethylaniline. Grade: > 95%. CAS No. 90357-53-2. Molecular formula: C12H9F3N2O. Mole weight: 254.21. | |
| Bicalutamide related compound A isomer A | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide. Molecular formula: C18H14F4N2O3S. Mole weight: 414.38. | |
| Bicalutamide related compound A isomer B | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide. Molecular formula: C18H14F4N2O3S. Mole weight: 414.38. | |
| Bicalutamide Sulfide | An intermediate of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Impurity J; N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenylthio)-2-hydroxy-2-methylpropanamide; (+/-)-Bicalutamide sulfide; (2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide; (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl-propanamide; (R,S)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide; Bicalutamide EP Impurity J. Grade: >95%. CAS No. 90356-78-8. Molecular formula: C18H14F4N2O2S. Mole weight: 398.38. | |
| Bicalutamide Sulfoxide | An impurity of Bicalutamide. Bicalutamide is a non-steroidal antiandrogen used primarily in the treatment of prostate cancer. It works by competitively inhibiting the androgen receptor (AR), blocking the effects of testosterone and dihydrotestosterone (DHT) on cancer cell growth. Synonyms: Bicalutamide Related Compound A; Bicalutamide USP RC A; N-[4-Amido-3-(trifluoromethyl)phenyl-3-[(4-fluorophenyl)-(R,S)-sulphinyl]-(R,S)-2-hydroxy-2-methylpropanamide; N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfinyl]-2-hydroxy-2-methylpropanamide; USP Bicalutamide Related Compound A; Bicalutamide USP Related Compound A. Grade: >95%. CAS No. 945419-64-7. Molecular formula: C18H14F4N2O3S. Mole weight: 414.38. | |
| Bicarphen | Diamine oxidase activator. Na+ channels blocker. Synonyms: Bicarphen; Quinuclidin-3-yldi-o-tolylmethanol hydrochloride; 1-azabicyclo[2.2.2]oct-3-yl[bis(2-methylphenyl)]methanol hydrochloride. Grade: ≥ 98 %.(TLC). CAS No. 57734-70-0. Molecular formula: C22H32ClNO3. Mole weight: 393.96. | |
| Bicifadine hydrochloride | Bicifadine hydrochloride is a potent antagonist of SLC6A2 (noradrenalin transporter) (IC50 = 55 nM). Bicifadine also has antagonistic activity at the 5-HT receptors and dopamine transporters (IC50 = 117 nM and 910 nM, respectively). It exhibits antinociceptive and antiallodynic properties in rodent models of acute, persistent, and chronic pain. Uses: The treatment of acute and chronic pain. Synonyms: 1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride. Grade: ≥98% by HPLC. CAS No. 66504-75-4. Molecular formula: C12H15N.HCl. Mole weight: 209.72. | |
| Biciromab | Biciromab is a monoclonal antibody that targets fibrin II beta chain, brin. Fibrin is a protein involved in the clotting of blood. Biciromab could label with the radioisotope indium-111 for the diagnosis of thromboembolism. Synonyms: Indium (111In) biciromab. Grade: 95%. CAS No. 138783-13-8. | |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Synonyms: GS-9883; GS 9883; GS9883. Grade: ≥98%. CAS No. 1611493-60-7. Molecular formula: C21H18F3N3O5. Mole weight: 449.39. | |
| Bictegravir glucuronide | Bictegravir glucuronide is a metabolite of Bictegravir, an HIV-1 integrase strand transfer inhibitor (INSTI). Bictegravir inhibits the strand transfer of viral DNA into the human genome, preventing HIV-1 virus replication and propagation. Synonyms: Glucuronide of bictegravir; Bictegravir metabolite M15. CAS No. 2365156-60-9. Molecular formula: C27H26F3N3O11. Mole weight: 625.50. | |
| Bictegravir sodium | Bictegravir sodium is a HIV-1 integrase strand transfer inhibitor that is derived from the drug dolutegravir. Synonyms: Bictegravir sodium|1807988-02-8|Bictegravir (sodium)|UNII-4L5MP1Y7W7|4L5MP1Y7W7|sodium; (1S,11R,13R)-3,6-dioxo-7-[(2,4,6-trifluorophenyl)methylcarbamoyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-dien-5-olate|Bictegravir sodium [USAN]|Bictegravir sodium (JAN/USAN)|CHEMBL3989867|SCHEMBL19991461|CHEBI:172961|BCP20910|HY-17605A|AC-30681|CS-0380750|D10910|N16970|A904622|Q27259952|GS-9883; GS 9883; GS9883; GS-9883-01; GS9883-01; GS 9883-01|(2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide monosodium salt|2,5-Methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-, sodium salt (1:1), (2R,5S,13aR)-|Sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1, 3]oxazepin-8-olate|sodium (2R,5S,13aR)-7,9-dioxo-10-[(2,4,6-trifluorobenzyl)carbamoyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate. Grade: >98%. CAS No. 1807988-02-8. Molecular formula: C21H17F3N3NaO5. Mole weight: 471.4. | |
| Bicuculline methiodide | A GABA receptor antagonist. Synonyms: (6S)-6-[(5R)-6,6-Dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one iodide. Grade: >98%. CAS No. 55950-07-7. Molecular formula: C21H20INO6. Mole weight: 509.29. | |
| Bicyclo[3.1.0]?hexane-?2,?3-?diol, 1-?(6-?amino-?9H-?purin-?9-?yl)?-?4-?(hydroxymethyl)?-?, (1R,?2S,?3R,?4R,?5S)?- | Bicyclo[3.1.0]hexane-2,3-diol, 1-(6-amino-9H-purin-9-yl)-4-(hydroxymethyl)-, (1R,2S,3R,4R,5S)- is a pivotal compound in the biomedical field, displaying paramount importance in therapeutics, employed for studying diverse ailments. Synonyms: (1R,2S,3R,4R,5S)-1-(6-Amino-9H-purin-9-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol. CAS No. 267642-30-8. Molecular formula: C12H15N5O3. Mole weight: 277.28. | |
| Bicyclo[3.1.0]?hexane-?2,?3-?diol, 4-?(6-?amino-?9H-?purin-?9-?yl)?-?1-?(hydroxymethyl)?-?, (1R,?2R,?3S,?4R,?5S)? | Bicyclo[3.1.0]hexane-2,3-diol, 4-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,2R,3S,4R,5S) is a formidable pharmaceutical compound with utilization extending to the research of disorders intricately linked to the purinergic network. Synonyms: Bicyclo[3.1.0]hexane-2,3-diol, 4-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, [1R-(1α,2β,3β,4α,5α)]-; (1R,2R,3S,4R,5S)-4-(6-Amino-9H-purin-9-yl)-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol. CAS No. 174498-00-1. Molecular formula: C12H15N5O3. Mole weight: 277.28. | |
| Bicyclol | Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. Synonyms: Bicyclol; SY 801; SY-801; SY801. Grade: >98%. CAS No. 118159-48-1. Molecular formula: C19H18O9. Mole weight: 390.34. | |
| Bicyclorisperidone | An impurirty of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Synonyms: 3-(4-Fluoro-2-hydroxyphenyl)-1-[2-(6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido-[1,2-a]pyrimidin-3-yl)ethyl]-2-aza-1-azoniabicyclo[2.2.2]oct-2-ene iodide. Grade: 95%. CAS No. 2231638-02-9. Molecular formula: C23H28FIN4O2. Mole weight: 538.41. | |
| Bicyclo Risperidone | An impurirty of Risperidone,Risperidone is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Synonyms: (1s,4r)-3-(4-Fluoro-2-hydroxyphenyl)-1-(2-(2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-3-yl)ethyl)-1,2-diazabicyclo[2.2.2]oct-2-en-1-ium Iodide. Grade: > 95%. Molecular formula: C23H28FN4O2. I. Mole weight: 538.4. | |
| BI-D1870 | BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 also has a Kd value of 3.5 uM for BRD4. Uses: Differentiation. Synonyms: BI-D1870; BI-D1870. Grade: 0.99. CAS No. 501437-28-1. Molecular formula: C19H23F2N5O2. Mole weight: 391.41. | |
| Bifemelane hydrochloride | Bifemelane hydrochloride is a MAO inhibitor displaying antidepressant activity. Bifemelane reverses catalepsy induced by tetrabenazine in mice and increases locomotor activity in MPTP-treated marmosets. Bifemelane has the potential to treat cerebral infarction and Alzheimer's disease for its neuroprotective and nootropic effects. Uses: Antidepressant. Synonyms: Celeport; Alnert; 4-(2-Benzylphenoxy)-N-methylbutylamine hydrochloride. Grade: ≥99% by HPLC. CAS No. 62232-46-6. Molecular formula: C18H23NO.HCl. Mole weight: 305.84. | |
| Bifenazate | Bifenazate, a positive allosteric modulator of GABA receptor, is a selective acaricide used to control a variety of mite pests on crops. Synonyms: D 2341; Floramite; Isopropyl 3-(4-Methoxy-3-biphenylyl)carbazate; Acramite; 2-(4-Methoxy[1,1'-biphenyl]-3-yl)hydrazinecarboxylic Acid 1-Methylethyl Ester; 1-Methylethyl 2-(4-methoxybiphenyl-3-yl)hydrazinecarboxylate; Isopropyl 2-(4-methoxy-[1,1'-biphenyl]-3-yl)hydrazinecarboxylate; Isopropyl 2-(4-methoxy-3-biphenylyl)hydrazinecarboxylate. Grade: 95%. CAS No. 149877-41-8. Molecular formula: C17H20N2O3. Mole weight: 300.35. | |
| Bifendate | Bifendate is a synthetic intermediate of schisandrin C, a dibenzocyclooctadiene derivative derived from lignans used in traditional medicine and also a anti-HBV drug used in the treatment of chronic hepatitis B. It has been used in some countries as a hepatoprotectant adjuvant in the treatment of liver diseases, such as chronic viral hepatitis or drug-induced hepatic damage. Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 7,7'-Dimethoxy-[4,4'-Bi-1,3-benzodioxole]-5,5'-dicarboxylic Acid 5,5'-Dimethyl Ester; DDB; Dimethyl 4,4'-Dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarboxylate; Dimethyl dicarboxylate Biphenyl; α-DDB. Grade: 97.0%~103.0%. CAS No. 73536-69-3. Molecular formula: C20H18O10. Mole weight: 418.36. | |
| Bifendate Impurity A | Bifendate Impurity A is an impurity of bifendate, rendering indispensable utility in the clinical therapy of an array of intricate hepatic pathologies. Grade: > 95%. CAS No. 1181519-47-0. Molecular formula: C18H14O8. Mole weight: 358.31. | |
| Bifendate Impurity B | Bifendate Impurity B is an impurity of Bifendate, a potent therapeutic agent treating chronic hepatitis B. Esteemed for its antiviral prowess and hepatic safeguards, Bifendate efficaciously assuages liver inflammation and diminishes the viral burden inherent in patients afflicted with this pathological viral infestation. Grade: > 95%. CAS No. 128142-41-6. Molecular formula: C18H16O9. Mole weight: 376.32. | |
| Bifendate Impurity E | Bifendate Impurity E is an impurity of Bifendate, facilitating the comprehensive control of multifarious cardiovascular disorders within the biomedical domain. Grade: > 95%. CAS No. 205117-47-1. Molecular formula: C19H16O10. Mole weight: 404.33. | |
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