BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ABT-491 Hydrochloride | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Alternative Names: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide;hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grades: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. |  |
| ABT-494 enantiomer | ABT-494 enantiomer. CAS No. 1310726-59-0. | |
| ABT-510 | ABT-510 is a synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). Alternative Names: ABT-510; ABT 510; ABT510. Grades: 98%. CAS No. 251579-55-2. Molecular formula: C46H83N13O11. Mole weight: 994.25. | |
| ABT-515 | ABT-515 is a formidable and discriminative antagonist exhibiting its capability by selectively inhibiting particular enzymes crucial in the advancement of malignant neoplasms. Alternative Names: 1-[(2R)-4-[5-[(4-fluorophenyl)-hydroxymethyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea; ABT-515; 189328-52-7; ABT-515; UNII-186W5U73P9; ABT 515; ABT515. Grades: >98%. CAS No. 189328-52-7. Molecular formula: C16H15FN2O3S. Mole weight: 334.37. | |
| ABT-518 | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Alternative Names: ABT 518; ABT518; N-((S)-1-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
| ABT-546 | ABT-546 is a potent, highly selective and active antagonist of ETA receptor with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human ETA. It is >25,000-fold more selectivity for ETA receptor than ETB receptor. It blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50s of 0.59 and 3 nM, respectively. Alternative Names: A-216546 free base; 3-Pyrrolidinecarboxylic acid, 1-(2-(dibutylamino)-2-oxoethyl)-2-(2,2-dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-, (2S,3R,4S)-; (2S,3R,4S)-1-[2-(Dibutylamino)-2-oxoethyl]-2-(2,2-dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-3-pyrrolidinecarboxylic acid. CAS No. 212481-66-8. Molecular formula: C30H48N2O6. Mole weight: 532.71. | |
| ABT-594 | ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan which is shown to exert potent analgesic action in models of nociceptive and persistent pain and to possess substantially reduced activity at peripheral nAChRs. Alternative Names: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine; Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline. CAS No. 198283-73-7. Molecular formula: C9H11ClN2O. Mole weight: 198.65. | |
| ABT-639 | ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found to have potential effect against neuropathic and nociceptive pain in studies. It has already been discontinued in the treatment of diabetic neuropathies. Uses: Abt-639 is a new blocker of selective t-type ca2+ channel blocker that has been found to have potential effect against neuropathic and nociceptive pain in studies. Alternative Names: ABT-639; ABT 639; ABT-639 free base; UNII-0G7D0CQ88I; SCHEMBL400073; 0G7D0CQ88I. Grades: 98%. CAS No. 1235560-28-7. Molecular formula: C20H20ClF2N3O3S. Mole weight: 455.91. | |
| ABT-639 hydrochloride | ABT-639 hydrochloride is a peripherally acting and selective T-type calcium channel blocker. Alternative Names: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide hydrochloride (1:1); Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-, hydrochloride (1:1). Grades: ≥95%. CAS No. 1235560-31-2. Molecular formula: C20H21Cl2F2N3O3S. Mole weight: 492.37. | |
| ABT670 | ABT670 is a drug which acts as a potent, superior orally bioavailable dopamine agonist selective for the D4 subtype. It was used as a possible treatment for erectile dysfunction. Uses: Abt670 was used as a possible treatment for erectile dysfunction. Alternative Names: ABT-670; ABT 670; Benzamide, 3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl]-;3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide. Grades: 98%. CAS No. 630119-43-6. Molecular formula: C19H23N3O2. Mole weight: 325.41. | |
| ABT 702 | ABT 702 is a non-nucleoside adenosine kinase (ADK) inhibitor (IC50 = 2 nM and 50 nM in cytosolic and intact cell assays, respectively). Study conformed that ABT702 could reduce pain and inflammation in animal models, yet be clastogenic in an in vitro Chinese Hamster micronucleus assay. Alternative Names: ABT 702; ABT702; ABT-702; 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine. Grades: 99%. CAS No. 214697-26-4. Molecular formula: C22H19BrN6O. Mole weight: 463.33. | |
| ABT 702 Dihydrochloride | ABT 702 Dihydrochloride is a potent and selective non-nucleoside adenosine kinase inhibitor with IC50 value of 1.7 nM. ABT 702 displays oral activity in animal models of pain and inflammation. In Mar 2005, ABT 702 was discontinued preclinical for Pain and Rheumatoid arthritis in USA. Uses: Anti-inflammation. Alternative Names: ABT702 Dihydrochloride; ABT-702 Dihydrochloride. Grades: 98%. CAS No. 1188890-28-9. Molecular formula: C22H21BrCl2N6O. Mole weight: 536.26. | |
| ABT-719 | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Alternative Names: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. Grades: 98%. CAS No. 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. | |
| ABT-719 HCl | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Alternative Names: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. Grades: 98%. CAS No. 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. | |
| ABT724 | ABT-724 is a dopamine D4 agonist originated by Abbott Laboratories with EC50 value of 12.4 nM. In Dec 2007, Phase-II for Erectile dysfunction was discontinued in USA. Now ABT-724 continues to be used in scientific research into the function of the D4 receptor. Uses: Erectile dysfunction. Alternative Names: ABT724; ABT 724; ABT-724; 2-((4-Pyridin-2-ylpiperazine-1-yl)methyl)-1H-benzimidazole;587870-77-7(ABT 724 trihydrochloride). Grades: 98%. CAS No. 70006-24-5. Molecular formula: C17H19N5. Mole weight: 293.37. | |
| ABT 724 trihydrochloride | ABT 724 trihydrochloride is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine) for treatment of sexual dysfunction. Alternative Names: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride; ABT-724 trihydrochloride; ABT724 trihydrochloride; ABT 724 trihydrochloride. Grades: ≥99% by HPLC. CAS No. 587870-77-7. Molecular formula: C17H19N5.3HCl. Mole weight: 402.75. | |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Alternative Names: ABT 737; ABT737; (R)-4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide. Grades: 98%. CAS No. 852808-04-9. Molecular formula: C42H45ClN6O5S2. Mole weight: 813.43. | |
| ABT 737-[d8] | Labelled ABT-737. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Alternative Names: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8. CAS No. 1217686-68-4. Molecular formula: C42H37D8ClN6O5S2. Mole weight: 821.48. | |
| ABT 751 | ABT 751, also called E7010, is a novel bioavailable tubulin-binding and antimitotic agent that inhibits microtubule polymerization (in neuroblastoma: IC50 = 0.6-2.6 μM; in non-neuroblastoma cell lines: IC50 = 0.7-4.6 μM). Alternative Names: N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide; E 7010; E-7010; E7010; N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; CHEMBL20684. CAS No. 141430-65-1. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| ABT-770 | ABT-770 is a selective and orally bioavailable MMP inhibitor. Alternative Names: ABT-770; ABT 770; ABT770; UNII-I8NWP25THF; N-[(2S)-1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-3-[4-[4-(trifluoromethoxy)phenyl]phenoxy]propan-2-yl]-N-hydroxyformamide; UNII-I8NWP25THF; CHEMBL40143. Grades: >98%. CAS No. 220614-50-6. Molecular formula: C22H22F3N3O6. Mole weight: 481.42. | |
| ABT-866 | ABT-866 is a novel alpha-adrenoceptor agent that demonstrates intrinsic activity at the α1A-adrenoceptor subtype present in the rabbit urethra (pD2=6.22, with 80% of the phenylephrine response). Alternative Names: N-[3-(1H-imidazol-5-ylmethyl)phenyl]ethanesulfonamide; ABT-866; ABT 866; ABT866; A 286666; A286666; A-286666. Grades: >98%. CAS No. 258526-74-8. Molecular formula: C12H15N3O2S. Mole weight: 265.33. | |
| ABT-888 | Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. Alternative Names: ABT-888; ABT 888; ABT888. CAS No. 912445-05-7. Molecular formula: C13H18Cl2N4O. Mole weight: 317.21. | |
| ABT 925 Fumerate | A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. Alternative Names: (E)-but-2-enedioic acid;2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; UNII-DMH23OL273; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base); ABT-925 anhydrous; ABT 925 Fumerate; ABT925 Fumerate; ABT-925 Fumerate. Grades: >98%. CAS No. 220519-07-3. Molecular formula: C24H31F3N6O5S. Mole weight: 572.604. | |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Alternative Names: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grades: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. | |
| a,b-Trehalose | a,b-Trehalose is a naturally occurring disaccharide, holding significant importance in the biomedical industry due to its extensive utilization. This multifaceted compound serves as a stabilizer for proteins, enzymes and vaccines, showcasing its diversity. Moreover, a,b-Trehalose exhibits promising potential in studying neurodegenerative conditions, specifically Parkinson's and Alzheimer's diseases. Alternative Names: Neotrehalose; a-D-Glucopyranosyl b-D-glucopyranoside; α,β-Trehalose; β-D-Glucopyranosyl α-D-glucopyranoside; Glc(b1-1a)Glc. CAS No. 585-91-1. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| ABTS Chromophore Diammonium Salt | ABTS Chromophore Diammonium Salt can inhibit catalase, a mammalian antioxidant enzyme which degrades hydrogen peroxide into water and oxygen species. Alternative Names: 2,2'-(1,2-Hydrazinediylidene)bis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Ammonium Salt (1:2); 2,2'-Azinobis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Diammonium Salt; 3-Ethyl-2-oxo-6-Benzothiazolinesulfonic Acid Azine Diammonium Salt; 2,2'-Azino-bis-(3-ethyl-benzthiazoline-6-sulfonate) Diammonium Salt; 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt; ABTS Diammonium Salt; Diammonium 2,2'-Azinobis(3-ethyl-6-benzothiazolinesulfonate); Diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate). Grades: ≥98%. CAS No. 30931-67-0. Molecular formula: C18H24N6O6S4. Mole weight: 548.68. | |
| Abu-Gly-OH | Abu-Gly-OH. Alternative Names: 2-Amino-N-butyric acid glycine. Grades: ≥ 98% (HPLC). CAS No. 16305-80-9. Molecular formula: C6H12N2O3. Mole weight: 160.17. | |
| ABX-1431 | ABX-1431 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 14 and 27 nM for human and rat enzyme, respectively). Alternative Names: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate. Grades: ≥98%. CAS No. 1446817-84-0. Molecular formula: C20H22F9N3O2. Mole weight: 507.3. | |
| ABX464-[13C6] | ABX464-[13C6]. Alternative Names: [13C6]-ABX464. Molecular formula: C10[13C]6H10ClF3N2O. Mole weight: 344.67. | |
| ABX (ANTIBODY EXCHANGER) | ABX (ANTIBODY EXCHANGER). Alternative Names: BAKERBOND(TM) ABX; BAKERBOND(TM) ABX PLUS; BAKERBOND(TM) WIDE-PORE ABX; ABX (ANTIBODY EXCHANGER); ABX PLUS (ANTIBODY EXCHANGER); XWP 500 POLYABX-35; XWP ABX. Grades: 95%. CAS No. 126850-08-6. Molecular formula: C4H11NO3. | |
| ABX-IL8 | ABX-IL8. | |
| Abyssinone V | Abyssinone V is extracted from the root bark of Erythrina mildbraedii. It is a protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 values ranging from 14.8 to 39.7 microM. Alternative Names: 77263-11-7;5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one;NSC618154;4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-,(2S)-;NSC 618154;CHEMBL454332;NSC-618154;5,7,4'-trihydroxy-3',5'-diprenylflavanone;4H-1-Benzopyran-4-one,3-Dihydro-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl]-, (S)-;4H-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-, (S)-. CAS No. 77263-11-7. Molecular formula: C28H22O7. Mole weight: 470.5. | |
| Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide | Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide is a fluorogenic substrate for neutral metalloendopeptidases. Alternative Names: XAGLA. CAS No. 100307-95-7. Molecular formula: C28H37N7O7. Mole weight: 583.63. | |
| Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH | Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH is a fluorogenic (FRET) substrate for endoproteinase AspN, Asp-specific proteases from Staphylococcus aureus, Bacillus licheniformis and Streptomyces griseus. Alternative Names: Fluorescent Substrate for Asp-Specific Proteases; (2-aminobenzoyl)-L-alanyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-phenylalanyl-3-nitro-L-tyrosyl-L-aspartic acid; Anthranilyl-Ala-Phe-Ala-Phe-Asp-Val-Phe-nitro-Tyr-Asp; N-(2-Aminobenzoyl)-L-alanyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-phenylalanyl-3-nitro-L-tyrosyl-L-aspartic acid. Grades: 95%. CAS No. 143147-74-4. Molecular formula: C62H71N11O18. Mole weight: 1258.29. | |
| Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp | Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenching substrate for Human Neutrophil Elastase. Alternative Names: N-(2-aminobenzoyl)-L-alanyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-methionyl-L-arginyl-L-arginyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide. CAS No. 824405-61-0. Molecular formula: C61H93N21O19S. Mole weight: 1456.59. | |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Alternative Names: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
| Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2 | Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2. Alternative Names: Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2. Grades: 95%. CAS No. 852572-93-1. Molecular formula: C58H84N14O22S2. Mole weight: 1393.51. | |
| ABZ-EIFVKKQ-EDDNP | ABZ-EIFVKKQ-EDDNP. Alternative Names: ABZ-GLU-ILE-PHE-VAL-PHE-LYS-GLN-ETHYLENEDIAMINE-DNP; ABZ-EIFVKKQ-EDDNP. CAS No. 848491-08-7. Molecular formula: C60H80N14O15. Mole weight: 1237.38. | |
| Abz-EPFWEDQ-EDDnp | Abz-EPFWEDQ-EDDnp is a peptide used as a research tool for the study of protein interactions. Abz-EPFWEDQ-EDDnp acts as an activator of receptors and ion channels. Alternative Names: Abz-Glu-Pro-Phe-Trp-Glu-Asp-Gln-EDDnp; N-(2-Aminobenzoyl)-L-α-glutamyl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-α-glutamyl-L-α-aspartyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide; L-Glutamamide, N-(2-aminobenzoyl)-L-α-glutamyl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-α-glutamyl-L-α-aspartyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-. CAS No. 534615-70-8. Molecular formula: C59H68N14O19. Mole weight: 1277.26. | |
| Abz-FR-K(Dnp)-P-OH | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Alternative Names: H-2Abz-Phe-Arg-Lys(Dnp)-Pro-OH; N-(2-Aminobenzoyl)-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-proline; o-Aminobenzoic acid-FRK(Dnp)P-OH; Abz-FR-K (Dnp)-P. Grades: ≥95%. CAS No. 500799-61-1. Molecular formula: C39H49N11O10. Mole weight: 831.87. | |
| Abz-FR-K(Dnp)-P-OH acetate | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Molecular formula: C41H53N11O12. Mole weight: 891.95. | |
| ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP | ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP. Alternative Names: H-2-ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP; ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP. Grades: 95%. CAS No. 152390-52-8. Molecular formula: C38H54N12O12. Mole weight: 870.91. | |
| ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2 | ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2. Alternative Names: ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2; HUMAN RHINOVIRUS 3C PROTEASE SUBSTRATE; HRV 3C PROTEASE SUBSTRATE; H-2-ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-4-NITRO-PHE-NH2. CAS No. 396096-53-0. Molecular formula: C57H77N13O16. Mole weight: 1200.3. | |
| ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH | ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH. Alternative Names: ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH; H-2-ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH; anthranilyl-Gly-Ala-Ala-Pro-Phe-nitro-Tyr-Asp. Grades: 95%. CAS No. 142689-23-4. Molecular formula: C42H49N9O14. Mole weight: 903.89. | |
| Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2 | Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2. Alternative Names: Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2. Grades: 95%. CAS No. 761443-02-1. Molecular formula: C37H49F3N12O14. | |
| Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH | Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH is a very efficient and selective FRET substrate for human cathepsin B (Km = 5.9 μM, kcat = 43 s-1, kcat/Km = 7288 mM-1s-1), with kcat/Km values of 133.3, 100, 32, 17, and 75 mM-1s-1 for cathepsin K, L, V, X, and cruzain, respectively. Alternative Names: H-2Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH; Abz-GIVRAK(Dnp); L-Lysine, N-(2-aminobenzoyl)glycyl-L-isoleucyl-L-valyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-; N-(2-Aminobenzoyl)glycyl-L-isoleucylvalyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grades: ≥95%. CAS No. 827044-38-2. Molecular formula: C41H61N13O12. Mole weight: 928.02. | |
| Abz-LFK(Dnp)-OH trifluoroacetate salt | Abz-LFK(Dnp)-OH trifluoroacetate salt is an angiotensin-converting enzyme (ACE) fluorescent peptide substrate that binds specifically to the C domain of ACE. It has been used to investigate the development of novel antibacterial calixarene derivatives, as well as the efficacy and toxicity of antimicrobial peptide M33 as a possible antimicrobial agent for lung infections and sepsis. Alternative Names: O-Aminobenzoic acid-Leu-Phe-Lys(DNP)-OH trifluoroacetate salt; Abz-Leu-Phe-Lys-DNP trifluoroacetate salt; (2-aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine trifluoroacetic acid; N-(2-Aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine trifluoroacetate (1:1); L-Lysine, N-(2-aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-, compd. with 2,2,2-trifluoroacetic acid (1:1); (2S)-2-[[(2S)-2-([(2S)-2-[(2-Aminobenzoyl)amino]-4-methylpentanoyl]amino)-3-phenylpropanoyl]amino]-6-(2,4-dinitroanilino)hexanoic acid trifluoroacetate. Grades: ≥97% by HPLC. CAS No. 1217437-31-4. Molecular formula: C34H41N7O9.C2HF3O2. Mole weight: 805.76. | |
| ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 | ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2. Alternative Names: H-2-ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2; ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2. CAS No. 290362-09-3. Molecular formula: C50H77N17O13. Mole weight: 1124.25. | |
| Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate | Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate. Molecular formula: C30H46O5. Mole weight: 486.68. | |
| Abz-Ser-Pro-3-nitro-Tyr-OH | Abz-Ser-Pro-3-nitro-Tyr-OH, a selective internal quenching fluorescence (FRET) substrate for angiotensin-converting enzyme 2 (ACE2), has potential application in the high-throughput screening of ACE2 inhibitors (Km = 23 μM, kcat/Km = 3.5·104 M-1s-1). Alternative Names: H-2Abz-Ser-Pro-Tyr(3-NO2)-OH; (2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-L-tyrosine; L-Tyrosine, N-(2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-. Grades: ≥95%. CAS No. 553644-01-2. Molecular formula: C24H27N5O9. Mole weight: 529.51. | |
| ABZ-TBU-GLY-TBU-GLY-ASN(ME)2-ALA-SER-SER-ARG-LEU-3-NITRO-TYR-ARG-OH | ABZ-TBU-GLY-TBU-GLY-ASN(ME)2-ALA-SER-SER-ARG-LEU-3-NITRO-TYR-ARG-OH. Alternative Names: ABZ-TBU-GLY-TBU-GLY-ASN(ME)2-ALA-SER-SER-ARG-LEU-3-NITRO-TYR-ARG-OH; H-2-ABZ-TBU-GLY-TBU-GLY-ASN(ME)2-ALA-SER-SER-ARG-LEU-3-NITRO-TYR-ARG-OH; 2-AMINOBENZOYL (ANTHRANILOYL)-*TERT-BUTYL-GLY-ASN(M; anthraniloyl-gly(t-butyl)-asn(methyl)2-ala-ser-ser-arg-leu-3-n. CAS No. 204909-37-5. Molecular formula: C61H97N19O18. Mole weight: 1384.54. | |
| Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp | Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenching substrate for Human Neutrophil Proteinase 3. Alternative Names: N-(2-aminobenzoyl)-L-valyl-L-alanyl-L-alpha-aspartyl-L-norvalyl-L-arginyl-L-alpha-aspartyl-L-arginyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide. CAS No. 1042405-14-0. Molecular formula: C53H80N20O18. Mole weight: 1285.33. | |
| AC 186 | AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Alternative Names: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; GTPL8897; SCHEMBL14672438; AC-186; AC 186; AC186; AKOS025147323; 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; AC 186|4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol. CAS No. 1421854-16-1. Molecular formula: C18H17F3O. Mole weight: 306.32. | |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Alternative Names: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide; AC187; salmon calcitonin (8-32) reduced; acetyl-(Asn30,Tyr32)sCT(8-37); AC-187. Grades: >98%. CAS No. 151804-77-2. Molecular formula: C127H205N37O40. Mole weight: 2890.25. | |
| AC 187 acetate | AC 187 acetate is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels, and increases food intake in vivo. Alternative Names: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2.CH3CO2H; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide acetic acid. Grades: ≥95%. Molecular formula: C129H209N37O42. Mole weight: 2950.26. | |
| AC1903 | AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 μM). Alternative Names: 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine. Grades: ≥95%. CAS No. 831234-13-0. Molecular formula: C19H17N3O. Mole weight: 303.4. | |
| AC1-IN-1 | AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with IC50 of 0.54 μM. Grades: 98% by HPLC. CAS No. 2762422-55-7. Molecular formula: C18H18FN5O2. Mole weight: 355.4. | |
| AC1NSVIE | AC1NSVIE. Alternative Names: (2R,3R,4R,5R,6S)-2-[[(2R,3S,4S,5R,6R)-6-[2-(3,4-dihydroxyphenyl)-2-hydroxyethoxy]-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-methyloxane-3,4,5-triol; 84233-74-9; B-D-Glucopyranoside,2-(3,4-dihydroxyphenyl)-2-hydroxyethyl 6-O-(6-deoxy-a-L-mannopyranosyl)-. CAS No. 84233-74-9. Molecular formula: C20H30O13. Mole weight: 478.447. | |
| Ac2-12 | Ac2-12 is an annexin / lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo. It reduces neutrophil adhesion and emigration. It has an anti-inflammatory effect. Alternative Names: LPC1; ANX1; ANXA-1. CAS No. 256447-08-2. Molecular formula: C63H94N14O17S. Mole weight: 1351.58. | |
| AC 220 dihydrochloride | AC 220 dihydrochloride is a potent and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3) used for the treatment of AML. Uses: The treatment of aml. Alternative Names: AC 220 dihydrochloride; AC220 dihydrochloride; AC-220 dihydrochloride; Quizartinib dihydrochloride; 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea dihydrochloride. Grades: 98%. CAS No. 1132827-21-4. Molecular formula: C29H32N6O4S.2HCl. Mole weight: 633.59. | |
| Ac2-26 | Ac2-26 is an annexin / lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has an anti-inflammatory effect. Alternative Names: Annexin-1 (2-26) (human); Ac2-26; Lipocortin-1 (2-26); Calpactin II (1-25) (dephosphorylated) (human); Annexin A1 (1-25) (dephosphorylated) (human); Annexin A1 (1-25) (dephosphorylated) (human); Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH. Grades: >98%. CAS No. 151988-33-9. Molecular formula: C141H210N32O44S. Mole weight: 3089.43. | |
| Ac2-26 TFA | Ac2-26 TFA is an annexin / lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has anti-inflammatory effect. Alternative Names: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys.TFA; Annexin A1 (1-25) (dephosphorylated) (human).TFA; L-Lysine, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-, trifluoroacetic acid. Grades: ≥95%. Molecular formula: C143H211F3N32O46S. Mole weight: 3203.45. | |
| AC 253 | AC 253 is an amylin (AMY3) receptor antagonist. It inhibits andrenomedulin-stimulated cAMP production in vitro. Alternative Names: L-Tyrosinamide, N-acetyl-L-leucylglycyl-L-arginyl-L-leucyl-L-seryl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-histidyl-L-arginyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-seryl-L-asparaginyl-L-threonyl-. Grades: ≥95%. CAS No. 151804-79-4. Molecular formula: C122H196N40O39. Mole weight: 2847.11. | |
| AC260584 | AC260584 is a potent and selective muscarinic M1 receptor allosteric agonist (pEC50 = 7.6). Studies indicated that AC260584 has a behavioral profile consistent with antipsychotic-like efficacy with the potential to improve cognitive performance and shows reduced liability for extrapyramidal symptoms. Alternative Names: 4-[3-(4-butylpiperidin-1-yl)propyl]-7-fluoro-1,4-benzoxazin-3-one; 4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one; AC 260584; AC-260584; AC260584. CAS No. 560083-42-3. Molecular formula: C20H29FN2O2. Mole weight: 348.45. | |
| AC 261066 | AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Alternative Names: AC261066; AC-261066; 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid; Benzoic acid, 4-[4-(2-butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluoro-. Grades: 98%. CAS No. 870773-76-5. Molecular formula: C17H20FNO4S. Mole weight: 353.41. | |
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Alternative Names: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. Grades: ≥98% by HPLC. CAS No. 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. | |
| AC 265347 | AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1) that bias signaling towards the accumulation of PERK1/2 and IP1. AC 265347 stimulates CaSR signaling in cellular proliferation and phosphatidyl inositol (PI) hydrolysis assays. It significantly activates human GABAB or type I PTH receptors. Alternative Names: AC 265347; AC-265347; AC265347; α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol; 1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol. Grades: ≥99% by HPLC. CAS No. 1253901-26-6. Molecular formula: C17H17NOS. Mole weight: 283.39. | |
| AC-2-METHOXY-PHE-OET | AC-2-METHOXY-PHE-OET. Alternative Names: N-ACETYL-3-(2-METHOXYLYPHENYL)-DL-ALANINE ETHYL ESTER; N-ACETYL-DL-(4-METHOXYPHENYL)ALANINE ETHYL ESTER; N-ACETYL-P-METHOXY-DL-PHENYLALANINE ETHYL ESTER; N-ACETYL-O-METHYL-DL-ORTHO-TYROSINE ETHYL ESTER; AC-2-METHOXY-PHE-OET; AC-PHE(2-OME)-OET. CAS No. 70529-51-0. Molecular formula: C14H19NO4. Mole weight: 265.3. | |
| Ac-2-Nal-OH | Ac-2-Nal-OH. Alternative Names: (S)-N-ACETYL-2-NAPHTHYLALANINE; (S)-2-Acetamido-3-(naphthalen-2-yl)propanoic acid. Grades: ≥ 95%. CAS No. 37439-99-9. Molecular formula: C15H15NO3. Mole weight: 257.3. | |
| AC-3-(2,6-DICHLORO-BZL)-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-TYR-NH2 | AC-3-(2,6-DICHLORO-BZL)-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-TYR-NH2. Alternative Names: AC-3-(2,6-DICHLORO-BZL)-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-TYR-NH2; PYX-1. Grades: 95%. CAS No. 140842-17-7. Molecular formula: C70H105Cl2N19O16. Mole weight: 1539.61. | |
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