MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Justicidin A | justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25001-57-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-117078. |  |
| Justicidin B | Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17951-19-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114275. | |
| JW480 | JW480 is a selective KIAA1363/AADACL1 inhibitor with oral activity, featuring IC50 values of 12 nM against human KIAA1363, 20 nM against mouse KIAA1363. JW480 blocks lipid deacetylase activity to restrain HAG metabolism and lowers retinyl ester hydrolase function in hepatic stellate cells. JW480 reduces MAGE lipid levels and inhibits migration, invasion, survival and tumor growth of prostate cancer cells. JW480 lowers PKCδ phosphorylation, facilitates HAGP accumulation, diminishes platelet aggregation, dense granule secretion and Ca2+ flux, delays arterial thrombosis and prolongs tail bleeding time in rats. JW480 can be used for the study of prostate cancer and thrombosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1354359-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107582. | |
| JW67 | JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 442644-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108442. | |
| JW74 | JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling with an IC50 of 420 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 863405-60-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19739. | |
| JWG-071 | JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250323-50-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108886. | |
| JWZ-5-13 | JWZ-5-13 is a CDK7 PROTAC degrader. JWZ-5-13 inhibits the proliferation of cancer cells. JWZ-5-13 is applicable to the research of ovarian cancer, diffuse large B-cell lymphoma, acute T-lymphoblastic leukemia and non-small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3103763-70-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161828. | |
| JX06 | JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 729-46-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19564. | |
| JY-2 | JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 339103-05-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153347. | |
| JYQ-164 | JYQ-164 is a small molecule inhibitor of Parkinson's disease protein 7 (PARK7/DJ-1) in humans. JYQ-164 works by covalently and selectively targeting Cys106, a key residue of PARK7 (IC50=21 nM). The high inhibitory effect of JYQ-164 on PARK7 is 5 times more potent than the previously reported inhibitor JYQ-88. JYQ-164 can be used in Parkinson's disease and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3117543-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163562. | |
| JYQ-173 | JYQ-173, a chemical probe, is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3117543-57-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163563. | |
| JZL 184 | JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1101854-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-15249. | |
| K00546 | K00546 is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443798-47-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103647. | |
| K02288 | K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1431985-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12278. | |
| K114 | K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 872201-12-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg. Product ID: HY-103470. | |
| K134 | K134 is a phosphodiesterase 3 (PDE3) inhibitor. The IC50s of K134 toward PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC33509. CAS No. 189362-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00186. | |
| K145 hydrochloride | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449240-68-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15779A. | |
| K-252a | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SF2370; Antibiotic K 252a; Antibiotic SF 2370. CAS No. 99533-80-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N6732. | |
| K284-6111 | K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 702668-62-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148013. | |
| K34c | K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 939769-93-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150124. | |
| K34c hydrochloride | K34c hydrochloride is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c hydrochloride reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c hydrochloride can be used in glioblastoma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2986315-25-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150124A. | |
| K579 | K579 is a potent and orally active dipeptidyl peptidase IV inhibitor. K579 inhibits the blood glucose elevation. K579 increases the plasma insulin and active forms of glucagon-like peptide-1 (GLP-1). K579 has the potential for the research of diabetic[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 440100-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103433. | |
| K-604 dihydrochloride | K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 217094-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100400A. | |
| K67 | K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC50 of 1.5 μM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC50 is 6.2 μM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2046250-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111126. | |
| K-7174 | K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 191089-59-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743. | |
| K-7174 dihydrochloride | K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 191089-60-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743A. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
| K-8012 | K-8012 is a Sulindac (HY-B0008) analog and RXRα antagonist with an IC50 of 9.2 μM. K-8012 inhibits the activation of AKT. K-8012 induces Apoptosis, redirecting the TNFα signaling pathway from survival to death. K-8012 exerts anticancer activity against lung cancer, prostate cancer, and breast cancer. K-8012 can be used in research related to lung cancer, prostate cancer, breast cancer, and hepatocellular carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346513-17-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121435. | |
| K-975 | K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2563855-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138565. | |
| KA2507 | KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1636894-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138799. | |
| KAAD-Cyclopamine | KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclopamine-KAAD. CAS No. 306387-90-6. Pack Sizes: 25 μg; 50 μg. Product ID: HY-100535. | |
| Kaempferide | Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kaempferol 4'-O-methyl ether. CAS No. 491-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15449. | |
| Kaempferitrin | Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lespedin; Lespenephryl. CAS No. 482-38-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0628. | |
| Kaempferol | Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kempferol; Robigenin. CAS No. 520-18-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-14590. | |
| Kaempferol-3,7-di-O-β-glucoside | Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kaempferol 3,7-diglucoside. CAS No. 25615-14-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8161. | |
| Kaempferol-3-O-(6-galloyl)-β-glucopyranoside | Kaempferol-3-O-(6-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC50 value of 5.19 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56317-05-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10776. | |
| Kaempferol 3-O-β-D-glucuronide | Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide. CAS No. 22688-78-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N7176. | |
| Kaempferol 3-O-gentiobioside | Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 μM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma. It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 22149-35-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N1510. | |
| Kaempferol 3-O-sophoroside | Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor (TLR) 2/4 for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19895-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2055. | |
| Kaempferol 3-sophoroside 7-rhamnoside | Kaempferol 3-sophoroside 7-rhamnoside acts as a potential biomarker[1]. Uses: Scientific research. Category: Natural products. CAS No. 93098-79-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2226. | |
| Kaempferol-7-O-β-D-glucopyranoside | Kaempferol-7-O-β-D-glucopyranoside is a flavonoid glycoside. Kaempferol-7-O-β-D-glucopyranoside exists in the root bark of Cudrania tricuspidata. Kaempferol-7-O-β-D-glucopyranoside inhibits Cu2+-induced lipid peroxidation of low-density lipoprotein. Kaempferol-7-O-β-D-glucopyranoside possesses antioxidant activity and scavenges DPPH free radicals[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 16290-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0627. | |
| Kaempferol (Standard) | Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kempferol(Standard); Robigenin (Standard). CAS No. 520-18-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14590R. | |
| KAG-308 | KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1215192-68-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128686. | |
| Kahweol | Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. Uses: Scientific research. Category: Signaling pathways. CAS No. 6894-43-5. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N6258. | |
| Kainic acid | Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 487-79-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2309. | |
| Kainic acid hydrate | Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 58002-62-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2309A. | |
| Kakkalide | Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58274-56-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4244. | |
| KALA | KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors[1]. Uses: Scientific research. Category: Peptides. CAS No. 187987-64-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2530. | |
| Kalii Dehydrographolidi Succinas | Kalii Dehydrographolidi Succinas (Potassium dehydroandrographolide succinate) is an antibiotic. Kalii Dehydrographolidi Succinas exerts immunostimulatory, anti-infective and anti-inflammatory effects. Kalii Dehydrographolidi Succinas shows potential for research on viral pneumonia and viral upper respiratory tract infections[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Potassium dehydroandrographolide succinate. CAS No. 76958-99-1. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N0677A. | |
| Kallikrein 5-IN-2 | Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC50=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361160-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-148949. | |
| KAN0438757 | KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1451255-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112808. | |
| Kanamycin | Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kanamycin A. CAS No. 59-01-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 200 mg. Product ID: HY-16566. | |
| Kanamycins sulfate | Kanamycins sulfate is a blood-brain barrier-permeable JNK1 and Bcl-2 modulator as well as an antibiotic, with broad-spectrum antibacterial, and biofilm-inhibiting activities, and it induces autophagy. Kanamycins sulfate promotes Bcl-2 phosphorylation to upregulate autophagy levels, triggering changes such as mitochondrial swelling and endoplasmic reticulum expansion. Consequently, it causes reversible neuronal damage in the dorsal cochlear nucleus without inducing significant neuronal apoptosis. In the presence of exogenous alanine or glucose, Kanamycins sulfate effectively kills drug-resistant bacteria, restores drug sensitivity of multidrug-resistant bacteria, and alleviates urinary tract and kidney infections in mice. Kanamycins sulfate can be applied to scientific research related to Mycobacterium tuberculosis, salmonellosis, brucellosis, shigellosis, urinary tract infections, and reversible neurotoxicity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70560-51-9. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g. Product ID: HY-W040128. | |
| Kanamycin sulfate | Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kanamycin A sulfate. CAS No. 25389-94-0. Pack Sizes: 10 mM * 1 mL in Water; 200 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-16566A. | |
| Kanshone C | Kanshone C is a sesquiterpenoid of Nardostachys chinensis roots[1]. Uses: Scientific research. Category: Natural products. CAS No. 117634-64-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10321. | |
| Kansuinine A | Kansuinine A inhibits IL-6-induced Stat3 activation. Kansuinine A possesses antiviral and anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57701-86-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126421. | |
| Karanjin | Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2534. | |
| KARI 201 hydrochloride | KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376132-24-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-171962A. | |
| Karrikin 2 | Karrikin 2 is a seed germination stimulant identified in smoke produced by plant combustion. Karrikins induce seed germination in Arabidopsis thaliana, lettuce, E. penduliflora and S. orbiculatum. Karrikin 2 upregulates the expression of gibberellin (GA) biosynthesis genes GA3ox1, GA3ox2 and the gibberellin GA4-responsive gene CP1 in Arabidopsis thaliana seeds[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 857054-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W187279. | |
| Karrikinolide | Karrikinolide is a plant-active compound. Karrikinolide can be extracted from smoke water (SW). Karrikinolide promotes total Cytokinin production. Plants treated with Karrikinolide exhibit superior growth in terms of rooting, leaf and bulb size, and fresh weight[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 857054-02-5. Pack Sizes: 1 mg. Product ID: HY-136302. | |
| Kartogenin | Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KGN. CAS No. 4727-31-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16268. | |
| Kartogenin sodium | Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KGN sodium. CAS No. 1401168-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16268A. | |
| Kasugamycin | Kasugamycin (Ksg) is an antibiotic which binds both the 30S and 70S ribosome but not isolated 50S subunits. Kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ksg. CAS No. 6980-18-3. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-B1864. | |
| Kasugamycin hydrochloride hydrate | Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ksg hydrochloride hydrate. CAS No. 200132-83-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1864B. | |
| KAT8-IN-1 | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 605-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-W015239. | |
| Kaurenoic acid | Kaurenoic acid is a diterpene derived from Sphagneticola trilobata. Kaurenoic acid has antibacterial, anti-inflammatory, anticonvulsant, analgesic, and aortic vasodilating effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6730-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N1469. | |
| KB-05 | KB-05 is an electrophilic fragment molecule that can be used in DIA-based quantitative chemical proteomic screening studies. Uses: Scientific research. Category: Signaling pathways. CAS No. 1956368-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149461. | |
| KB05yne | KB05yne is a site-selective, alkyne-functionalized electrophilic "probe" fragment probe designed for covalent ligand discovery, with preferential reactivity toward specific cysteine residues in proteins. KB05yne strongly labels wild-type target proteins (e.g., CDKN2AIP, HPCAL1) but does not label their cysteine-to-alanine mutants, confirming site-specific cysteine reactivity. KB05yne can be used for the discovery and optimization of site-specific covalent ligands, and is applicable to proteins with diverse structures and functions, especially in studies targeting cysteine residues in cancer-related or difficult-to-purify proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2724919-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-177554. | |
| KB-0742 | KB-0742 is a potent, selective and orally active CDK9 inhibitor with an IC50 of 6 nM for CDK9/cyclin T1. KB-0742 is selective for CDK9/cyclin T1 with >50-fold selectivity over other CDK kinases. KB-0742 has potent anti-tumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2416873-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137478. | |
| KB130015 | KB130015 (KB015) is an orally active and potent ThRα and ThRβ (thyroid hormone receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 activates hERG1 channels (EC50 = 12.2 μM) and large-conductance Ca2+-activated K+ (BKCa) channels formed by hSlo1 (α) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KB015. CAS No. 147030-48-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120026. | |
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