MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| YZL-51N | YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031072-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159124. |  |
| Z218484536 | Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223877-07-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160955. | |
| Z26395438 | Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2803-63-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155725. | |
| Z-3578 | Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 473687-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172458. | |
| Z36-MP5 | Z36-MP5 is an Mi-2β-targeted inhibitor, with IC50 of 0.082 μM. Z36-MP5 can reduce Mi-2β ATPase activity and reactivates ISG transcription. Z36-MP5 can stimulate T-cell-mediated cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2839660-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161344. | |
| Z433927330 | Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 μM, ~0.7 μM and ~1.1 μM for mAQP7, mAQP3 and mAQP9, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1005883-72-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126074. | |
| (Z)-4EGI-1 | (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 901787-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19831A. | |
| Z4P | Z4P is a BBB-penetrable IRE1 inhibitor with an IC50 of 1.13 μM. Z4P in combination with Temozolomide (HY-17364) inhibits the growth and recurrence of glioblastoma and has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361760-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153773. | |
| Z57346765 | Z57346765 is an inhibitor that targets the ADP-binding pocket of PGK1, with a Kd of 20.9 μM for human PGK1, and exhibits anticancer activity. Z57346765 reduces the activity of the metabolic enzyme PGK1 during glycolysis, regulates lipid peroxidation and cancer cell proliferation, and promotes lipid peroxidation in cervical cancer cells. Z57346765 inhibits the proliferation of cervical cancer and clear cell renal cell carcinoma cells in xenograft mouse models, and induces the expression of genes associated with cell metabolism, DNA replication and cell cycle. Z57346765 is used in research related to cervical cancer, clear cell renal cell carcinoma and breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1016340-64-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W195984. | |
| Z62954982 | Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZINC08010136. CAS No. 1090893-12-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115376. | |
| ZA3-Ep10 | ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery. Uses: Scientific research. Category: Signaling pathways. CAS No. 2090299-48-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145794. | |
| Zabadinostat | Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. Zabadinostat has no activity against HDAC class II. Zabadinostat has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CXD101. CAS No. 934828-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100748. | |
| Zabedosertib | Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with immunomodulatory potential, IC50 is 3.55 nM. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors[1]. Zabedosertib exhibits anti-inflammatory property against IL-β, LPS (HY-D1056) and Imiquimod (HY-B1080) induced inflammation[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 1834845. CAS No. 1931994-81-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139374. | |
| Zabofloxacin hydrochloride | Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DW-224a. CAS No. 623574-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106410A. | |
| Zadavotide guraxetan | PSMA I&T is an effective inhibitor of prostate-specific membrane antigen (PSMA). PSMA I&T can be used for SPECT/CT imaging and radionuclide studies in triple-negative breast cancer and prostate cancer (PCa)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PSMA I&T; PNT-2002. CAS No. 2192281-54-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148761. | |
| Z-AEVD-FMK | Z-AEVD-FMK is a caspase-10 inhibitor. Z-AEVD-FMK can inhibit the activation of Bid and the release of apoptosis-inducing factor (AIF) in mitochondria in cells, resulting in a significant decrease in the number of apoptotic cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1135688-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125305. | |
| Zafirlukast | Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI 204219. CAS No. 107753-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-17492. | |
| Zagociguat | Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CY-6463; IW-6463. CAS No. 2201048-82-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145607. | |
| Zagotenemab | Zagotenemab (LY3303560) is a humanized anti-tau antibody that selectively binds and neutralises tau deposits in the brain. Zagotenemab can be used in Alzheimer's disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3303560. CAS No. 2019133-28-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99164. | |
| ZAK-IN-1 | ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile - α motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2362525-64-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128326. | |
| Z-Ala-Ala-Asn-AMC | Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cbz-Ala-Ala-Asn-AMC. CAS No. 149697-16-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-136626. | |
| Z-Ala-Ala-Asp-CMK | Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-AAD-CMK. CAS No. 183284-21-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10004. | |
| Zalcitabine | Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2',3'-Dideoxycytidine; ddC; Dideoxycytidine. CAS No. 7481-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-17392. | |
| Zaldaride maleate | Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGS-9343B; KW 5617. CAS No. 109826-27-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-105118A. | |
| Zaltenibart | Zaltenibart (OMS906) is an IgG4 humanized monoclonal antibody and MASP-3 inhibitor. By inhibiting MASP-3, Zaltenibart achieves upstream inhibition of the alternative complement pathway. MASP-3 is an upstream activator of Factor D (Factor D), a key enzyme in the alternative complement pathway. Zaltenibart prevents both intravascular hemolysis and extravascular hemolysis. Zaltenibart is applicable to research related to paroxysmal nocturnal hemoglobinuria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OMS906. CAS No. 2527079-60-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990952. | |
| Zalunfiban dihydrochloride | Zalunfiban (RUC-4) dihydrochloride is a potent, selective platelet αIIbβ3 antagonist (IC50=45 nM). Zalunfiban dihydrochloride can be used for the research of myocardial infarction (MI)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RUC-4 dihydrochloride. CAS No. 2815778-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119350B. | |
| Zalutumumab | Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2F8; HUMAX-EGFR. CAS No. 667901-13-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99155. | |
| Zamaporvint | Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RXC004. CAS No. 1900754-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153855. | |
| Zampilimab | Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2). Zampilimab inhibits TG2 crosslinking transamidation activity with an IC50 of 0.25 nM and a Kd of <50 pM. Zampilimab improves renal fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UCB-7858. CAS No. 2098280-42-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99512. | |
| Zanamivir | Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 139110-80-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13210. | |
| Zandatrigine | Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel NaV1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of NaV1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as NaV1.1 and NaV1.2, and has minimal effect on NaV1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study NaV1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBI-921352; XEN901. CAS No. 2154406-04-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147423. | |
| Zandelisib | Zandelisib (ME-401) is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ME-401; PWT-143. CAS No. 1401436-95-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109198. | |
| Zanidatamab | Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZW 25; ZW-49 Antibody. CAS No. 2169946-15-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99380. | |
| Zanolimumab | Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD4 Recombinant Antibody. CAS No. 652153-01-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99266. | |
| Zansecimab | Zansecimab (LY-3127804) is a monoclonal antibody against angiopoietin 2 (Ang - 2). Zansecimab can be used in research on angiogenesis, immunomodulation and anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-3127804. CAS No. 2415205-37-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99510. | |
| Zanubrutinib | Zanubrutinib (BGB-3111) is a selective and orally active Bruton tyrosine kinase (Btk) inhibitor (IC50: 0.3 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGB-3111. CAS No. 1691249-45-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101474A. | |
| Zanubrutinib (Standard) | Zanubrutinib (Standard) is the analytical standard of Zanubrutinib. This product is intended for research and analytical applications. Zanubrutinib (BGB-3111) is a selective and orally active Bruton tyrosine kinase (Btk) inhibitor (IC50: 0.3 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGB-3111 (Standard). CAS No. 1691249-45-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101474AR. | |
| Zanzalintinib | Zanzalintinib (XL092) is an orally active, ATP-competitive inhibitor of multiple receptor tyrosine kinases (RTKs) including MET, VEGFR2, AXL and MER, with IC50s in cell-based assays of 15 nM, 1.6 nM, 3.4 nM, 7.2 nM respectively. Zanzalintinib exhibits anti-tumor activity. Zanzalintinib has the potential for kinase-dependent diseases and conditions research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL092. CAS No. 2367004-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138696. | |
| ZAP-180013 | ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873080-25-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136179. | |
| Zapnometinib | Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD0184264; ATR-002. CAS No. 303175-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139558. | |
| Zaprinast | Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M&B 22948. CAS No. 37762-06-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1816. | |
| Zaptuzumab | Zaptuzumab (AD5-10) is a DR5-specific humanized monoclonal antibody that selectively binds to DR5 with high affinity. Zaptuzumab specifically induces cancer cell death by both caspase-apoptosis and autophagic cell death (ACD). Zaptuzumab activates both ADCC and CDC. Zaptuzumab induces ROS generation and GSH level reduction. Zaptuzumab shows a significant suppression of the tumor growth and good safety in various xenografts mice tumor models[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AD5-10; oba-01 Antibody. CAS No. 2378046-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991570. | |
| Zaragozic acid A | Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase. Zaragozic acid A is an inhibitor of acute hepatic cholesterol synthesis in mouse (IC50 = 6 μM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Squalestatin S1. CAS No. 142561-96-4. Pack Sizes: 1 mg. Product ID: HY-116290. | |
| Zardaverine | Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 101975-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15485. | |
| Z-Arg-Arg-AMC hydrochloride | Z-Arg-Arg-AMC hydrochloride is a highly selective fluorescent Cathepsin B substrate. Z-Arg-Arg-AMC hydrochloride can be hydrolyzed by Cathepsin B to produce a fluorescent product for enzyme activity detection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136132-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-134434. | |
| Z-Arg-Arg-pNA | Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122630-71-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4500. | |
| Z-Arg-SBzl | Z-Arg-SBzl is a substrate of both bovine and activated human protein C[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88253-86-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5125. | |
| Zarutatug | Zarutatug (TORL-3-600 antibody) is an IgG1κ humanized antibody targeting cadherin 17 (CDH17). It selectively binds to cell-surface CDH17, triggering endocytosis and trafficking to lysosomes. Zarutatug can be used to construct ADCs, such as TORL-3-600[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TORL-3-600 antibody. CAS No. 3038456-02-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991728. | |
| Zasocitinib | Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NDI-034858; TAK-279. CAS No. 2272904-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150096. | |
| Zastaprazan | Zastaprazan (JP-1366) is a proton pump inhibitor and a potent potassium-competitive acid blocker. Zastaprazan can be used in the research of gastrointestinal inflammatory diseases or gastric acid-related diseases such as gastroesophageal reflux disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JP-1366. CAS No. 2133852-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139557. | |
| Zastaprazan citrate | Zastaprazan (JP-1366) citrate is a Proton pump inhibitor and potent potassium-competitive acid blocker. Zastaprazan citrate can be used in the research of gastrointestinal inflammatory diseases or gastric acid-related diseases such as gastroesophageal reflux disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JP-1366 citrate. CAS No. 2936619-43-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139557A. | |
| Zatolmilast | Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BPN14770. CAS No. 1606974-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117571. | |
| Zaurategrast | Zaurategrast (CT7758) is a potent and oral-effective α4-integrin inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT7758. CAS No. 455264-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-70073. | |
| Zavondemstat | Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC50 ≤ 0.08 μM against human KDM4A-D and a K? of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: QC8222 free base; TACH 101 free base. CAS No. 1851412-93-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-148807. | |
| ZC0109 | ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC50s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037850-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151978. | |
| (Z)-Capsaicin | (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zucapsaicin; Civamide; cis-Capsaicin. CAS No. 25775-90-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1583. | |
| ZCL278 | ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 587841-73-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13963. | |
| ZCZ011 | ZCZ011 is a potent and brain-penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1998197-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-118140. | |
| ZD06519 | ZD06519 (7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin). CAS No. 2873460-17-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156513. | |
| ZD 7155hydrochloride | ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 146709-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102093. | |
| ZD7288 | ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI D7288. CAS No. 133059-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101346. | |
| Z-DEVD-FMK | Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210344-95-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-12466. | |
| Zearalanone | Zearalanone is a reductive metabolite of Zearalenone (HY-103447). Zearalanone binds to serum albumin across multiple species. Zearalanone enhances the binding affinity of Warfarin (HY-B0687) to serum albumin[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5975-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6678. | |
| Zearalenone | Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Mycotoxin F2; Toxin F2. CAS No. 17924-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103447. | |
| Zearalenone-13C18 | Zearalenone-13C18 (Mycotoxin F2-13C18; Toxin F2-13C18) is the 13C labeled Zearalenone (HY-103447)[1]. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mycotoxin F2-13C18; Toxin F2-13C18. CAS No. 911392-43-3. Pack Sizes: 30 μg (74.35 μM * 1.2 mL in Acetonitrile). Product ID: HY-103447S1. | |
| Zeaxanthin | Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144-68-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120318. | |
| Zebularine | Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a Ki of 0.95 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC309132; 4-Deoxyuridine. CAS No. 3690-10-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13420. | |
| Zedoresertib | Zedoresertib (Debio 0123) is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. Zedoresertib inhibits phospho-CDC2. Zedoresertib abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. Zedoresertib can be used for researching anticancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Debio 0123; WEE1-IN-5. CAS No. 2243882-74-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147054. | |
| Zefamenib | Zefamenib (BN-104) is an effective selective brain membrane protein inhibitor with oral activity, and it's also a Menin inhibitor, it can block the Menin-MLL interaction and leads to the degradation of Menin protein. Zefamenib is a weak hERG inhibitor, with an IC50 greater than 100 μM. Zefamenib has anti-tumor activity and can be used in cancer research, such as for acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BN-104; BNM-1192; Menin-MLL inhibitor 27. CAS No. 2938995-50-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153714. | |
| Zegocractin | Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CM-4620. CAS No. 1713240-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101942. | |
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