MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Zinc Gluconate | Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD50 of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4468-2-4. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g. Product ID: HY-W145499. |  |
| Zinc(II) tetrakis(4-carboxyphenyl)porphine | Zinc(II) tetrakis(4-carboxyphenyl)porphine(Zn(II) meso-Tetra(4-carboxyphenyl) Porphine) is a metal-organic framework (MOF). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zn(II) meso-Tetra(4-carboxyphenyl) Porphine. CAS No. 27647-84-3. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W036428. | |
| Zinc Protoporphyrin | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9. CAS No. 15442-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101193. | |
| Zinc Pyrithione | Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13463-41-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0572. | |
| Zinc sulfate heptahydrate | Zinc sulfate heptahydrate is a hydrate that is the heptahydrate form of zinc sulfate. Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7446-20-0. Pack Sizes: 10 mM * 1 mL in Water; 10 g; 50 g; 100 g. Product ID: HY-N3025. | |
| Zinc trifluoromethanesulfonate | Zinc trifluoromethanesulfonate (Zinc (II) Triflate) is a Zn2+ salt commonly used in potentiometric titration to determine the stability constants of Zn2+-quinoline sulfonamide complexes. Aqueous solutions of Zinc trifluoromethanesulfonate form micellar structures, which result in poor desolvation kinetics of Zn2+ and induce dendrite growth on zinc anodes, failing to support long-term cycling of zinc anodes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zinc(II) Triflate. CAS No. 54010-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-21170E. | |
| Zineb | Zineb is an agricultural fungicide of the dithiocarbamate class. Its toxicity is relatively low, and there is little evidence of human harm from exposure. Oxidative stress is one of the main factors contributing to diseases caused by Zineb. Zineb does not alter the activity of any superoxide dismutase enzymes. Catalase (CAT) activity was reduced only by Zineb. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zinc ethylene-1, 2-bisdithiocarbamate. CAS No. 12122-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-W127739. | |
| Zingerone | Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3]. Zingerone can cross the blood-brain barrier (BBB)[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vanillylacetone; Gingerone. CAS No. 122-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-14621. | |
| Zinlirvimab | Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 10-1074. CAS No. 2417213-75-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99102. | |
| Zinpyr-1 | Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn2+ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 288574-78-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-D0155. | |
| Zinquin | Zinquin is a cell-impermeant fluorescent sensor and used to observe reactive Zn2+. λex/λem=368/490 nm. Uses: Scientific research. Category: Signaling pathways. CAS No. 151606-29-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0982. | |
| Zinquin ethyl ester | Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn2+ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181530-09-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124171. | |
| Zinterol hydrochloride | Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MJ 9184 hydrochloride. CAS No. 38241-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-14304A. | |
| ZIP14-IN-1 | ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. ZIP 14-IN-1 inhibits ZIP14 while sparing ZIP8 (SLC39A8). ZIP 14-IN-1 efficiently blocks ZIP14-mediated uptake of multiple divalent metals (zinc, iron, manganese and cadmium). ZIP 14-IN-1 binds to a pocket formed at the dimer interface of ZIP14, obstructing the metal transport pathway. ZIP 14-IN-1 effectively reverses the consequent elevation of reactive oxygen species (ROS) and lipid peroxidation, attenuating metal-induced cytotoxicity. ZIP 14-IN-1 can be uses for cancer cachexia research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PPTD. CAS No. 1048-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-179571. | |
| Zipalertinib | Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS6417; CLN-081. CAS No. 1661854-97-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112299. | |
| Ziprasidone | Ziprasidone (CP-88059), an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-88059. CAS No. 146939-27-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14542. | |
| Ziprasidone hydrochloride monohydrate | Ziprasidone (CP-88059) hydrochloride monohydrate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone hydrochloride monohydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP 88059 hydrochloride monohydrate. CAS No. 138982-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17407. | |
| Ziresovir | Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AK0529; RO-0529. CAS No. 1422500-60-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109142. | |
| Ziritaxestat | Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GLPG1690. CAS No. 1628260-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101772. | |
| Ziv-aflibercept | Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609655-49-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108798. | |
| Ziyuglycoside II | Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35286-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0332. | |
| ZJCK-6-46 | ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3096805-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162750. | |
| ZK159222 | ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156965-15-0. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-12397. | |
| ZK168281 | ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 186371-96-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-12407. | |
| ZK 216348 | ZK 216348 ((+)-ZK 216348) is a nonsteroidal selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC50s of 20.4 nM and 79.9 nM, respectively. ZK 216348 has antiinflammatory activity similar to Prednisolone and induces less transactivation-mediated side effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-ZK 216348. CAS No. 669073-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123352. | |
| ZK824859 hydrochloride | ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2436760-76-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114330A. | |
| ZL006 | ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 1181226-02-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100456. | |
| ZL0420 | ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230496-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112149. | |
| ZL0454 | ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2. Uses: Scientific research. Category: Signaling pathways. CAS No. 2229042-77-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112150. | |
| ZL0580 | ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2377151-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126428. | |
| ZLD115 | ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2980653-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149334. | |
| ZLD2218 | Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis , and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC50 value of 107 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2713974-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144236. | |
| Z-LEHD-FMK | Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210345-04-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1010. | |
| Z-Leu-Arg-AMC | Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm, Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156192-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-142021. | |
| Z-Leu-Leu-Arg-AMC | Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90468-17-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4390. | |
| Z-Leu-Leu-Glu-AMC | Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of proteasome. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-LLE-AMC. CAS No. 348086-66-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123053. | |
| Z-LEVD-FMK | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1135688-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128707. | |
| (Z)-Ligustilide | (Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1]. (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2]. (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81944-09-4. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N0401A. | |
| (Z-LL)2 ketone | (Z-LL)2 ketone is an inhibitor of ketone with an IC50 value of 50 nM. (Z-LL)2 ketone inhibits processing of thep-Prlsignal peptide[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313664-40-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1425. | |
| Z-LLY-FMK | Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Calpain Inhibitor IV. CAS No. 133410-84-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136750. | |
| ZLN005 | ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 49671-76-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17538. | |
| ZLN024 hydrochloride | ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883548-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16708A. | |
| Z-LVG-CHN2 | Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 119670-30-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108137. | |
| ZLY025 | ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC50 of 42.7 nM. ZLY025 exhibits broad-spectrum antiproliferative activity against various tumor cells with IC50 values ranging from 0.08 to 2.45 μM. ZLY025 can induce cells apoptosis and G1 phase arrest. ZLY025 can be used for the research of cancer, such as lung cancer[1]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 3070379-34-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-179289. | |
| Z-Lys-OMe hydrochloride | Z-Lys-OMe hydrochloride is a synthetic intermediate that can be used in the synthesis of peptide enzyme substrates and lysine cationic surfactants. Uses: Scientific research. Category: Signaling pathways. CAS No. 26348-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W098322. | |
| Z-LYS-SBZL monohydrochloride | Z-LYS-SBZL (monohydrochloride) is a lysine derivative[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-N-Carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride. CAS No. 69861-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141447. | |
| ZM241385 | ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 139180-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-19532. | |
| ZM323881 hydrochloride | ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 193000-39-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15467A. | |
| ZM-447439 | ZM-447439 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 331771-20-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10128. | |
| ZnAF-1 | ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection. ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 321859-09-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-D0156. | |
| ZNF207-IN-1 | ZNF207-IN-1 (compound C16) is a potent inhibitor of Zinc Finger Protein 207 (ZNF207), with IC50 values ranging from 0.5-2.5 μM for inhibiting sphere formation and 0.5-15 μM for cytotoxicity. ZNF207-IN-1 exhibites efficient permeability across the blood-brain barrier[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923208-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161303. | |
| Zn(II) Mesoporphyrin IX | Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZnMP. CAS No. 14354-67-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W583212. | |
| ZNL-05-044 | ZNL-05-044 is a CDK11 inhibitor with an IC50s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay). ZNL-05-044 leads to G2/M cell cycle arrest and impairs RNA splicing[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034411-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155874. | |
| Zodasiran | Zodasiran is a siRNA targeted to ANGPTL3 in the liver. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-ANG3. CAS No. 2232918-66-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-177671. | |
| Zolantidine dimaleate | Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKF 95282 dimaleate. CAS No. 104076-39-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101373A. | |
| Zolbetuximab | Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: IMAB362; Claudiximab; GC-182. CAS No. 1496553-00-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99058. | |
| Zoldonrasib | Zoldonrasib (RMC-9805) is a potent and orally active KRAS G12D inhibitor.Zoldonrasib induces apoptosis in KRAS G12D mutant cancer cells. Zoldonrasib has the potential for the research of KRAS G12D mutant cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RMC-9805; KRAS G12D inhibitor 18. CAS No. 2922732-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156819. | |
| Zoledronic Acid | Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zoledronate; CGP 42446; CGP42446A; ZOL 446. CAS No. 118072-93-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-13777. | |
| Zoledronic acid monohydrate | Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate. CAS No. 165800-06-6. Pack Sizes: 50 mg; 100 mg; 1 g. Product ID: HY-13777A. | |
| Zoliflodacin | Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ETX0914; AZD0914. CAS No. 1620458-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17647. | |
| Zolmitriptan | Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist that can cross the blood-brain barrier, with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW-311C90; 311C90. CAS No. 139264-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B0229. | |
| Zolucatetide | Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC50 of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FOG-001; I-66. CAS No. 3044032-95-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10925. | |
| Zomiradomide | Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC50=6 nM), thereby inhibiting the NF-κB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC50 for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway[1][2][3]. (Pink: target protein ligand PROTAC IRAK4 ligand-5 (HY-168311), Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313)). Uses: Scientific research. Category: Signaling pathways. Alternative Names: KT-413. CAS No. 2655656-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153368. | |
| Zongertinib | Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI 1810631. CAS No. 2728667-27-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148810. | |
| Zonisamide | Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinsons disease and cardiac hypertrophy[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AD 810; CI 912. CAS No. 68291-97-4. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg. Product ID: HY-B0124. | |
| Zopolrestat | Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP73850. CAS No. 110703-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19687. | |
| Zoptarelin doxorubicin | Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AEZS-108; AN-152. CAS No. 139570-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16532. | |
| Zorevunersen sodium | Zorevunersen sodium is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen sodium increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen sodium restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen sodium can be used for research on Dravet syndrome[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STK-001 sodium. CAS No. 2415330-05-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148410A. | |
| Zorifertinib | Zorifertinib (AZD3759) is a potent, orally active, BBB-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively. Zorifertinib induces cancer cell apoptosis. Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD3759. CAS No. 1626387-80-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-18750. | |
| Zosuquidar | Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RS 33295-198; LY-335979. CAS No. 167354-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-15255. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.